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37 results on '"Gustavsson, Anita"'

1. No excess long-term mortality in stage I-IIA Hodgkin lymphoma patients treated with ABVD and limited field radiotherapy

Author

Lagerlöf, Ingemar, Holte, Harald, Glimelius, Ingrid, Björkholm, Magnus, Enblad, Gunilla, Erlanson, Martin, Fluge, Øystein, Fohlin, Helena, Fosså, Alexander, Goldkuhl, Christina, Gustavsson, Anita, Johansson, Ann-Sofie, Linderoth, Johan, Nome, Ole, Palma, Marzia, Åkesson, Lisa, Østenstad, Bjørn, Raud, Cecilia, Glimelius, Bengt, Molin, Daniel, Lagerlöf, Ingemar, Holte, Harald, Glimelius, Ingrid, Björkholm, Magnus, Enblad, Gunilla, Erlanson, Martin, Fluge, Øystein, Fohlin, Helena, Fosså, Alexander, Goldkuhl, Christina, Gustavsson, Anita, Johansson, Ann-Sofie, Linderoth, Johan, Nome, Ole, Palma, Marzia, Åkesson, Lisa, Østenstad, Bjørn, Raud, Cecilia, Glimelius, Bengt, and Molin, Daniel

Abstract

When treating limited stage classical Hodgkin lymphoma (cHL), balancing treatment efficacy and toxicity is important. Toxicities after extended-field radiotherapy are well documented. Investigators have aimed at reducing toxicity without compromising efficacy, mainly by using combined modality treatment (CMT), i.e. chemotherapy and limited-field radiotherapy. In some clinical trials, radiotherapy has been omitted. We evaluated 364 patients with stage I-IIA cHL treated between 1999 and 2005. Patients were treated with two or four cycles of doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD) according to presence of risk factors, followed by 30 Gy limited-field (reduced compared to involved-field) radiotherapy. After a median follow-up of 16 years for survival, freedom from progression at five and ten years was 93% and overall survival at 5 and 10 years was 98% and 96%, respectively. Only two relapses, out of 27, occurred after more than 5 years. There was no excess mortality compared to the general population. Of the analysed subgroups, only patients with progression within five years showed significant excess mortality. The absence of excess mortality questions the concept of omitting radiotherapy after short-term chemotherapy, a strategy that has been associated with an elevated risk of relapse but not yet with a proven reduced long-term excess mortality.

Published
2020
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11. No excess long‐term mortality in stage I‐IIA Hodgkin lymphoma patients treated with ABVD and limited field radiotherapy

Author

Lagerlöf, Ingemar, primary, Holte, Harald, additional, Glimelius, Ingrid, additional, Björkholm, Magnus, additional, Enblad, Gunilla, additional, Erlanson, Martin, additional, Fluge, Øystein, additional, Fohlin, Helena, additional, Fosså, Alexander, additional, Goldkuhl, Christina, additional, Gustavsson, Anita, additional, Johansson, Ann‐Sofie, additional, Linderoth, Johan, additional, Nome, Ole, additional, Palma, Marzia, additional, Åkesson, Lisa, additional, Østenstad, Bjørn, additional, Raud, Cecilia, additional, Glimelius, Bengt, additional, and Molin, Daniel, additional

Published
2019
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17. Konstruktionslek på förskolan

Author

Gustavsson, Anita

Subjects
construction materials, construction-play, Barn, förskola, konstruktionslek, play environment, konstruktionsmaterial, Children, preschool, lekmiljö
Abstract

Genom kvalitativa intervjuer med fem förskollärare och observationer av konstruktionsmaterial på förskolan har jag fått svar på mina frågeställningar. Mina frågeställningar handlar om vilka material förskolan har till tredimensionell konstruktionslek inomhus och om det arbetas medvetet med tredimensionell konstruktionslek. Syftet med studien är att undersöka förutsättningarna för tredimensionell konstruktionslek på förskolan. Rapporten visar att tillgången till konstruktionsmaterial på förskolorna inte är särskilt varierad och inte tillräckligt stor. Enligt svaren på intervjuerna är den största orsaken bristen på tid för pedagogerna att vara delaktig i konstruktionsleken. Det saknades även tid att hålla ordning på konstruktionsmaterialet. Pedagogerna arbetar inte medvetet med konstruktionslek och upplever att de saknar tillräckliga kunskaper inom ämnet. Utifrån gällande styrdokument är leken viktig för barns lärande. Barnen skall utveckla sin förmåga att bygga, skapa och konstruera med hjälp av olika material. Denna studie visar att för att uppfylla dessa krav bör lärare i förskolan få mera kunskaper om konstruktionslekens betydelse och hur man kan arbeta med den. My purpose with this study is to investigate the preschools conditions of the three-dimensional construction play. My questions are: what indoor material the preschool posses and the awareness of working with three-dimensional construction play. The answers I got are based on the qualitative interviews with five preschoolteachers and also from doing observations of the preschools construction materials. The report shows that the access to the construction materials are not that varied and not big enough. According to the answers from the interviews, is the main reason the preschoolteachers lack of time to participate in the construction play. They are also lacking time to maintain the order of the construction materials. The preschoolteachers don’t work consciously with the construction play and they feel that they don’t have adequate knowledge in this subject. On the basis of current control documents are the children’s play important for their learning. The children shall develop the ability to build, create and construct with help from different materials. This study shows that to fulfil these demands, the preschoolteachers should get more knowledge about the meaning of the construction play and how to work with it.

Published
2008

18. Construction-play at the preschool

Author

Gustavsson, Anita

Subjects
construction materials, construction-play, Barn, förskola, konstruktionslek, play environment, konstruktionsmaterial, Children, preschool, lekmiljö
Abstract

Genom kvalitativa intervjuer med fem förskollärare och observationer av konstruktionsmaterial på förskolan har jag fått svar på mina frågeställningar. Mina frågeställningar handlar om vilka material förskolan har till tredimensionell konstruktionslek inomhus och om det arbetas medvetet med tredimensionell konstruktionslek. Syftet med studien är att undersöka förutsättningarna för tredimensionell konstruktionslek på förskolan. Rapporten visar att tillgången till konstruktionsmaterial på förskolorna inte är särskilt varierad och inte tillräckligt stor. Enligt svaren på intervjuerna är den största orsaken bristen på tid för pedagogerna att vara delaktig i konstruktionsleken. Det saknades även tid att hålla ordning på konstruktionsmaterialet. Pedagogerna arbetar inte medvetet med konstruktionslek och upplever att de saknar tillräckliga kunskaper inom ämnet. Utifrån gällande styrdokument är leken viktig för barns lärande. Barnen skall utveckla sin förmåga att bygga, skapa och konstruera med hjälp av olika material. Denna studie visar att för att uppfylla dessa krav bör lärare i förskolan få mera kunskaper om konstruktionslekens betydelse och hur man kan arbeta med den. My purpose with this study is to investigate the preschools conditions of the three-dimensional construction play. My questions are: what indoor material the preschool posses and the awareness of working with three-dimensional construction play. The answers I got are based on the qualitative interviews with five preschoolteachers and also from doing observations of the preschools construction materials. The report shows that the access to the construction materials are not that varied and not big enough. According to the answers from the interviews, is the main reason the preschoolteachers lack of time to participate in the construction play. They are also lacking time to maintain the order of the construction materials. The preschoolteachers don’t work consciously with the construction play and they feel that they don’t have adequate knowledge in this subject. On the basis of current control documents are the children’s play important for their learning. The children shall develop the ability to build, create and construct with help from different materials. This study shows that to fulfil these demands, the preschoolteachers should get more knowledge about the meaning of the construction play and how to work with it.

Published
2008

19. Long-term risk of cardiovascular disease in Hodgkin lymphoma survivors : retrospective cohort analyses and a concept for prospective intervention

Author

Andersson, Anne, Näslund, Ulf, Tavelin, Björn, Enblad, Gunilla, Gustavsson, Anita, Malmer, Beatrice, Andersson, Anne, Näslund, Ulf, Tavelin, Björn, Enblad, Gunilla, Gustavsson, Anita, and Malmer, Beatrice

Abstract

Previous studies have shown increased cardiovascular mortality as late side effects in Hodgkin lymphoma (HL) patients. This study identifies stratifying risk factors for surveillance and defines concepts for a clinical feasible and noninvasive prospective protocol for intervention of cardiovascular side effects. HL patients diagnosed between 1965 and 1995 (n = 6.946) and their first-degree relatives (FDR) were identified through the Swedish Cancer Registry and the Swedish Multigeneration Registry. For the HL and FDR cohort, in-patient care for cardiovascular disease (CVD) was registered through the Hospital Discharge Registry, Sweden. Standard incidence ratios of developing CVD for the HL cohort were calculated. A markedly increased risk for in-patient care of CVD was observed in HL patients with HL diagnosed at age 40 years or younger and with more than 10 years follow-up. In the HL survivors, a family history of congestive heart failure (CHF) and coronary artery disease (CAD) increased the risk for these diseases. The Swedish Hodgkin Intervention and Prevention study started in 2007. In the pilot feasibility study for prospective intervention (47 patients), about 25% of the cases had side effects and laboratory abnormalities. These patients were referred to a cardiologist or general practitioner. In the prospective cohort, a positive family history for CHF or CAD could be a stratifying risk factor when setting up a surveillance model. The prospective on-going study presents an intervention model that screens and treats for comorbidity factors. This article also presents an overview of the study concept.

Published
2009
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28. Adenosine diphosphate ribosyl transferase in marrow cells of patients with acute myeloid leukemia is related to differentiation and drug sensitivity.

Author

Pero, Ronald W., Olofsson, Tor, Gustavsson, Anita, and Kjellén, Elisabeth

Abstract

The levels of adenosine diphosphate ribosyl transferase (ADPRT) have been quantified in Ficoll-Isopaque isolated marrow cells from 36 patients with acute myeloid leukemia (AML). The growth pattern in agar at diagnosis was also determined, and in 16 patients the drug sensitivity of the clonogenic cells (CFU-GM) to cytosine arabinoside and daunorubicin was measured. The ADPRT activities of the various marrow cell preparations correlated to the morphological diagnoses, growth patterns, drug sensitivities to cytosine arabinoside, and to the prognoses of the AML patients. Hence, ADPRT may be a useful marker for the pathophysiology associated to AML. [ABSTRACT FROM PUBLISHER]

Published
1985

36. No excess long-term mortality in stage I-IIA Hodgkin lymphoma patients treated with ABVD and limited field radiotherapy.

Author

Lagerlöf I, Holte H, Glimelius I, Björkholm M, Enblad G, Erlanson M, Fluge Ø, Fohlin H, Fosså A, Goldkuhl C, Gustavsson A, Johansson AS, Linderoth J, Nome O, Palma M, Åkesson L, Østenstad B, Raud C, Glimelius B, and Molin D

Subjects
Adult, Aged, Antineoplastic Combined Chemotherapy Protocols adverse effects, Bleomycin administration & dosage, Bleomycin adverse effects, Child, Combined Modality Therapy, Dacarbazine administration & dosage, Dacarbazine adverse effects, Disease-Free Survival, Doxorubicin administration & dosage, Doxorubicin adverse effects, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neoplasm Staging, Survival Rate, Vinblastine administration & dosage, Vinblastine adverse effects, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Hodgkin Disease mortality, Hodgkin Disease therapy, Registries
Abstract

When treating limited stage classical Hodgkin lymphoma (cHL), balancing treatment efficacy and toxicity is important. Toxicities after extended-field radiotherapy are well documented. Investigators have aimed at reducing toxicity without compromising efficacy, mainly by using combined modality treatment (CMT), i.e. chemotherapy and limited-field radiotherapy. In some clinical trials, radiotherapy has been omitted. We evaluated 364 patients with stage I-IIA cHL treated between 1999 and 2005. Patients were treated with two or four cycles of doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD) according to presence of risk factors, followed by 30 Gy limited-field (reduced compared to involved-field) radiotherapy. After a median follow-up of 16 years for survival, freedom from progression at five and ten years was 93% and overall survival at 5 and 10 years was 98% and 96%, respectively. Only two relapses, out of 27, occurred after more than 5 years. There was no excess mortality compared to the general population. Of the analysed subgroups, only patients with progression within five years showed significant excess mortality. The absence of excess mortality questions the concept of omitting radiotherapy after short-term chemotherapy, a strategy that has been associated with an elevated risk of relapse but not yet with a proven reduced long-term excess mortality., (© 2019 British Society for Haematology and John Wiley & Sons Ltd.)

Published
2020
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37. Patients above sixty years of age with Hodgkin's lymphoma treated with a new strategy.

Author

Enblad G, Gustavsson A, Sundström C, and Glimelius B

Subjects
Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Doxorubicin administration & dosage, Drug Administration Schedule, Drug Therapy, Combination, Etoposide administration & dosage, Female, Humans, Male, Middle Aged, Prednisone administration & dosage, Survival Rate, Vincristine administration & dosage, Hodgkin Disease drug therapy
Abstract

In the Swedish National Care Programme for Hodgkin's lymphoma (HL) a less intensive chemotherapy regimen with individualized dosing (LVPP/OEPA) was introduced in 1989. In total, 139 patients, 77 between 1985 and 1988 and 62 between 1989 and 1992, were studied. Mean ages were 72 and 71 years, respectively. One hundred and nineteen patients were treated with curative intention, 63 (82%) between 1985 and 1988 vs. 56 (90%) between 1989 and 1992 (p = 0.11). All patients (13 vs. 20) treated with radiotherapy only achieved a complete remission (CR). The CR rates (67% vs. 65%) for patients treated with 6-8 cycles of chemotherapy were also similar in the two time periods. The 5-year survival rate was 45% in the period 1985-1988 and 48% in 1989-1992. The survival of elderly HL patients was thus not improved from 1985-1988 to 1989-1992. Thus efforts to improve the chemotherapy regimen with individualized dosing did not change the outcome. Many patients experienced myelosuppression and opportunistic infections that may have contributed to the poor treatment results.

Published
2002
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