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The keratocystic odontogenic tumor (KOT) is a lesion that requires special considerations because of its clinical behavior and its specific histopathological aspects. The present study aims to show a case of KOT with its radiographic and histopathological features. In this study a 43-year-old female patient presented with a unilocular radiolucent image located in the posterior region of the mandibular body on the left side, extending to the ascending ramus, were observed on a panoramic radiograph. Further, she undergoes a CT scan followed by biopsy for histopathological examination. The pathological cavity was lined by parkeratinized epithelium with a basal layer arranged in a “palisade” pattern cells with nuclear hyperchromatism were observed, confirming that it was a KOT. Therefore, dental surgeons’ knowledge of dental tumor of odontogenic tumor lesions, especially KOT is of fundamental importance to provide a correct diagnosis of these lesions, thereby preventing late diagnosis which can lead to the significant mutilation in the patients.

Aims: To evaluate the mandibular bone cortical of patients with mucopolysaccharidosis on panoramic radiograph, through radiomorfometric indices. Study Design: Case-control study. Place and Duration of Study: Sample: Department of Diagnostic Imaging of the Universidade Estadual da Paraíba, Campus VIII, in the city of Araruna, PB, between January and December of 2015. Methodology: Panoramic radiographs of sixteen patients with mucopolysaccharidosis and 32 controls, organized by gender and age, composed the sample. The mandibular panoramic index, gonial index, antegonial index and mental index were evaluated. Pearson's Chi-square test, Fisher's exact test and Mann-Whitney test were used to statistical analysis with a level of significance of 5.0%. Results: Mucopolysaccharidosis patients were mostly female (62.5%), with a mean age of 12.31 + 7.16 years, MPS VI (50.0%) being the most prevalent. Patients with mucopolysaccharidosis had higher values in the gonial (1.86+0.48), the antegonical (4.36+1.24) and the mental (5.24+1.21). However, only the antegoniac index presented a significant difference (P=0.047). Conclusion: The antegoniac index was higher in patients with mucopolysaccharidosis and the other radiomorphometric measures were similar to those observed in the control group. Apparently, mucopolysaccharidosis is not related to decreased bone to mandibular quality.

Objective: to investigate through a cross-sectional study the prevalence and pattern of tobacco, alcohol, and illicit drugs use among non-heterosexual and transgender inmates of a female prison com...

BACKGROUND/AIM Due to the increase in incarceration rates, the prison community has attracted much concern in the recent past. Although people in prison are often socially disadvantaged and vulnerable to a range of health problems, there is a lack of information on the oral health conditions of prisoners. Thus, the aim of this study was to survey the oral problems of a sample of the male incarcerated population of Brazil, focusing on dental trauma. MATERIAL AND METHODS The research was undertaken over a three-month period in 2017. It was a cross-sectional study of 756 prisoners of the Curado Prison Complex, located in Recife, PE. Using a previously calibrated examiner, dental trauma was measured with the Andreasen index. Etiology of dental trauma and socio-demographic data were collected with questions developed for this survey. Standard descriptive statistics were used to report frequency estimates. The chi-square test, Fisher's exact test, and Mann-Whitney U-test were used to compare groups. In addition, a binary logistic regression was performed to identify whether the studied variables could predict the occurrence of dental trauma. RESULTS The prevalence of dental trauma in the sample was 10.8% and most of the cases (42.7%) occurred due to violent events. A higher frequency of violent etiology was observed in cases that occurred during imprisonment (p = 0.037). Individuals that suffered dental trauma during incarceration were more likely to have been incarcerated for longer periods of time (p = 0.043). The main type of injury found was enamel and dentin fracture without pulp exposure (68%). The most affected tooth was the upper right central incisor (40%). CONCLUSION These results underline the high prevalence of dental trauma experienced by men in prison.

Background This study aimed to evaluate sociodemographic and clinical factors influencing overall survival (OS) in patients with oral squamous cell carcinoma (OSCC). Material and Methods Medical charts of 547 patients with OSCC from a public hospital in northeastern Brazil seen between 1999 and 2013 were evaluated. Survival analysis was performed using the Kaplan-Meier method. The influence of age, sex, ethnicity, clinical stage, anatomical location, type of treatment, and comorbidities on the patients’ prognosis was evaluated. Cox proportional hazards regression model was used to identify independent prognostic factors. Results The 5-year OS was 39%. Multivariate analysis showed that age < 40 years (HR = 2.20; 95%CI: 1.02-4.72) and a single treatment modality (HR = 1.91; 95%CI: 1.37-2.67) were associated with a poor prognosis, while early clinical stage resulted in better outcomes (HR = 0.38; 95%CI: 0.25-0.58). Conclusions OSCC patients in advanced clinical stages, diagnosed at a younger age, and submitted to a single therapeutic modality have a poorer prognosis. Key words:Head and neck cancer, oral cancer, oral squamous cell carcinoma, survival, prognosis.

Introdução: As neoplasias que surgem nas glândulas salivares são relativamente raras, as quais representam uma grande variedade de comportamentos biológicos e subtipos histológicos benignos e malignos. Objetivo: Determinar a frequência relativa e a distribuição de uma série de casos diagnosticados histopatologicamente como neoplasias primárias em glândulas salivares. Métodos: Realizou-se um estudo transversal exploratório, por meio detécnica da observação indireta dos prontuários preenchidos entre o período de janeiro de 2002 e dezembro de 2012. Foram registrados dados referentes ao sexo, idade, raça, localização anatômica, tipo de glândula acometida, tamanho, natureza e diagnóstico histopatológico da neoplasia. Os dados coletados foram analisados por meio de estatística descritiva. Resultados: Foram identificados 124 casos, dos quais 98 (79,03%) eram neoplasias benignas e 26 (20,97%), malignas. Com relação à localização anatômica, a maioria das lesões ocorreu na glândula parótida (84,7%), seguindo-se as glândulas salivares menores (8%) e, por último, a glândula submandibular (7,3%). As neoplasias de glândulas salivares menores ocorreram mais frequentemente no palato. A neoplasia benigna mais frequente foi o adenoma pleomórfico (87,8%), e o carcinoma adenoide cístico (42,3%) foi a neoplasia maligna mais comum. As neoplasias malignas foram mais comuns na glândula parótida (76,9%) e nas glândulas salivares menores (23%). Conclusão: Os dados demográficos aqui apresentados poderão ser úteis para uma melhor compreensão das características clínicas e biológicas das neoplasias de glândulas salivares.

Introduction: Apical dentoalveolar abscesses associated with sinusitis are very uncommon and may expose patients to unfavorable outcomes. Case-report: A 25-year-old female patient sought medical care due to severe, recurrent, long-term frontal facial pain and symptom relief through analgesics. A tomographic examination of the skull did not identify any pathological cerebral alterations. It did, however, evidence diffuse and irregular mucous thickening of all nasal cavities. The patient was referred to an otorhinolaryngologist, who diagnosed the condition as bilateral chronic inflammatory rhinosinusopathy. A rhinoscopy was performed and antibiotic associated with corticoid was prescribed. After the procedure, sinus infection diffusion to the dental tissues was observed, and the patient required emergency dental care due to diffuse facial cellulitis and swelling associated to tooth 26. Due to the absence of clinical signs indicative of carious infection, the condition was diagnosed as an uncommon case of acute dentoalveolar abscess of sinusal origin. After endodontic access for initial drainage, chemical-mechanical preparation of the root canals was performed, in two sessions. After 30 days, a tomography of the sinuses was performed, and results indicated a significant improvement of the infectious process. Due to the rarity of the case presented herein, it is of significant importance to understand the clinical, radiographic and protocol aspects of the case, in order to attend similar cases, as well as the joint action of the dental surgeon and the otorhinolaryngologist for rhinogenic and odontogenic infection management.

O objetivo do presente estudo foi desenvolver e realizar a validação de conteúdo e de face de uma escala de atitudes relacionadas às competências odontológicas (EA-CO). Tratou-se de estudo de desenvolvimento metodológico envolvendo construção e validação de uma escala, com abordagem quanti e qualitativa. O referencial teórico para o construto da escala envolveu o conceito de atitude no campo da Psicologia Social, e o de competência, no campo da Educação, qualificada pelas Diretrizes Curriculares Nacionais para os cursos de Odontologia, originando os indicadores: Empatia na relação profissional-paciente, Aprendizagem ao longo da vida, Disponibilidade para aprendizagem interprofissional, Proteção aos direitos do paciente, Responsabilidade social e Inteligência emocional. Dez especialistas participaram da validação de face da matriz de indicadores (Técnica do Grupo Nominal) e dos itens (Questionário) e a versão preliminar foi testada em piloto com 17 estudantes de Odontologia. Houve consenso para permanência dos indicadores, exceto para Inteligência emocional. A escala (tipo Likert, 5 pontos) resultou em 53 itens, sendo 13 alterados da versão original. A EA-CO foi desenvolvida e atendeu aos critérios de validação de conteúdo e de face utilizados no estudo.

A Covid-19, originada em dezembro de 2019, se espalhou rapidamente pela China tornando-se uma emergência pública. Pacientes com diagnóstico de câncer são considerados um grupo altamente vulnerável devido ao seu estado sistêmico imunossuprimido causado pelo tratamento oncológico, logo, este trabalho tem como objetivo descrever as apresentações clínicas e alterações orais em pacientes oncológicos diagnosticados com Covid-19. Trata-se de um estudo transversal com 20 pacientes oncológicos internados com Covid-19. Dados sobre o câncer, presença de comorbidades e sintomas relacionados a Covid-19 foram coletados, exame clínico da cavidade oral foi realizado durante todo o internamento, com o intuito de verificar alterações em boca. Resultados: A média de idade dos pacientes foi de 53 anos e a maioria era do sexo feminino. Tumores sólidos representaram 90%, sendo o útero a região mais frequente. A maioria dos pacientes não estavam sob tratamento oncológico no período em que foram infectados com o vírus (50%). Hipertensão arterial sistêmica foi a comorbidade mais frequente (30%), seguida de Diabetes Mellitus (25%). Nenhum dos pacientes foram admitidos em UTI, a média de internamento foi de 13 dias e todos receberam alta hospitalar. Tosse e hipogeusia estavam entre os sintomas mais frequentes. Hipossalivação e infecção fúngica foram as alterações mais frequentemente observadas. Conclusão: Alterações orais apresentadas em pacientes oncológicos estão de acordo com os achados da literatura, enquanto que as apresentações clínicas foram opostas as evidências de que doença oncológica é um fator de possível piora clínica em pacientes infectados pela Covid-19.

O termo currículo refere-se ao percurso seguido pelo estudante em uma instituição de ensino superior desde o momento em que inicia seu processo de formação profissional até a graduação. As Diretrizes Curriculares Nacionais (DCN) para os cursos de graduação em Odontologia, instituídas pela Resolução CNE/CES 3, de 19 de fevereiro de 2002, definem os princípios, fundamentos, condições e procedimentos da formação de cirurgiões-dentistas, primando pela formação de um profissional integral. As Instituições de Ensino Superior (IES) têm em mãos o desafio de construir projetos pedagógicos que operacionalizem esse conceito, de modo a atender as demandas da sociedade. Neste contexto, este estudo de abordagem qualitativa e exploratória objetivou analisar criticamente as matrizes curriculares de dois cursos de Odontologia, pertencentes a IES localizadas em regiões distintas do país. A metodologia utilizada considerou um modelo lógico para avaliação da formação do cirurgião-dentista com base nas DCN, proposto por Pessoa e Noro. Foram analisadas as dimensões referentes à integração entre os ciclos básico e profissionalizante, ao desenvolvimento de competências e habilidades desejáveis, a formação profissional, além do desenvolvimento do estágio curricular e atividades complementares. Foi verificado que as duas estruturas curriculares estão em consonância com os ideais preconizados pelas DCN, apesar de conterem pontos que não fortalecem a formação profissional do egresso. Observou-se que ambas as matrizes apresentam potencialidades e fragilidades, que inspiram discussões.

To perform an epidemiological and clinical analysis of cases of oral cancer (OC) and potentially malignant disorders (PMDs). This retrospective study was based on the analysis of data from 631 patients who attended a clinic of the Interdisciplinary League of Oral Cancer (LINCCO) of a public university of northeastern Brazil over a time period of 12 years. Sociodemographic, economic, and clinical variables were investigated. Descriptive, bivariate, and multivariate statistical analyses using Poisson regression were performed. During the analyzed period, 19.3% (n = 122) of cases were related to diagnoses of some type of OC or PMDs. The majority of patients were male (60.7%) and in the fifth (22.0%) or sixth (23.7%) decades of life. The reported smoking and alcohol consumption were 27.0% and 27.9%, respectively. The most prevalent lesions were actinic cheilitis (48.4%) and squamous cell carcinoma (SCC) (23.8%). The most affected anatomical region was the lower lip (45.1%). The prevalence of smoking was higher among those who presented with OC [prevalence ratio (PR) = 2.56, 95% confidence interval (CI) = 1.54–4.24, p

Introdução: A transmissão SARS-CoV-2 de humano para humano pode ocorrer e o risco de propagação no ar durante os procedimentos odontológicos geradores de aerossóis permanece uma preocupação. Acredita-se que um enxaguatório bucal antimicrobiano pré-operacional reduza o número de micróbios orais. No entanto, a eficácia do enxaguatório bucal pré-procedimento na redução do número de microrganismos disseminados por meio do aerossol gerado por procedimentos odontológicos ainda não está clara. Objetivo: avaliar através de uma revisão de literatura o uso de enxaguantes bucais na redução da carga viral do SARS-CoV-2. Materiais e Método: O levantamento literário para esta pesquisa foi realizado no período de dezembro de 2019 a 10 de agosto de 2020 nas bases de dados Scielo e Medline/PubMed. Na estratégia de busca, foram utilizadas as palavras “SARS-CoV-2”, “2019-nCoV”, “COVID-19”, “Dentistry”, “Odontologia”, “Odontología”, “Mouthwashes”, “Antissépticos Bucais” e “Antisépticos Bucales”. Resultados: Uma busca sistematizada foi realizada, foram encontrados 661 artigos, após a realização da leitura criteriosa dos artigos completos foram selecionados 42 artigos. 88% dos estudos indicavam o uso de Peróxido de hidrogênio a 1%, 76% indicavam Povidine 0,2% e apenas 19% o uso da Clorexidina a 0,12%. Conclusão: Os estudos presentes na literatura apresentam divergências nas indicações e porcentagens dos enxaguantes indicados. Os protocolos clínicos devem ser avaliados para reduzir o risco de transmissão e proteger pacientes e profissionais.Descritores: Infecções por Coronavírus; Betacoronavirus; Odontologia; Antissépticos Bucais.ReferênciasGe ZY, Yang LM, Xia JJ, Fu XH, Zhang YZ. Possible aerosol transmission of COVID-19 and special precautions in dentistry. J Zhejiang Univ Sci B. 2020;21(5):361-68. Peng X, Xu X, Li Y, Cheng L, Zhou X, Ren B. Transmission routes of 2019-nCoV and controls in dental practice. 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The aim of the present study was to analyze the epidemiology of maxillofacial odontogenic and non-odontogenic cysts diagnosed for 30 years in a Brazilian population. A retrospective descriptive cross-sectional study was performed. Biopsy records were obtained from the archives of a Brazilian referral center between 1989 and 2019. Data regarding age, gender, anatomical location, and histopathological diagnosis were collected and categorized. Further, a literature search for similar studies was performed. A total of 6.994 biopsy records were evaluated, but only 367 (5.24%) cases were classified as odontogenic cysts (OC) or non-odontogenic cysts (NOC). Among all cystic lesions, 341 cases (92.9%) were OC and 26 cases (7.1%) were NOC. These lesions were more common in females (n = 208 / 56.67%) and located mostly in the mandible (n = 195 / 53.1%). In patients with OC, the radicular cyst was the most frequent (n = 134 / 36.5%), followed by the dentigerous cyst (n = 101 / 27.5%) and the odontogenic keratocyst (n = 52 / 14.2%). Patients with NOC had a higher frequency of epidermoid cyst (n = 12 / 3.3%), oral lymphoepithelial cyst (n = 7 / 1.9%), and nasopalatine duct cyst (n = 4 / 1.1%). The OCs were more prevalent than NOCs, and inflammatory cysts were the most common among all the OCs.

Opportunistic infections in oral cavity can cause serious complications in immunocompromised cancer patients, being quick and efficient treatments options essential. This article proposes to report two clinical cases of adolescent patients diagnosed with leukemia and who presented infectious conditions in the oral cavity, in which antimicrobial photodynamic therapy was used as a adjuvant therapy to abbreviate the course of oral lesions.

Purpose The aim of this study was to describe the relation between occlusal features and enzyme replacement therapy in patients with mucopolysaccharidoses. Materials and Methods A cross-sectional study was conducted. The sample consisted of 20 patients with mucopolysaccharidoses, 10 of whom were undergoing treatment at a hospital in northeast Brazil. Occlusal features were evaluated by clinical examination and panoramic radiography. A structured questionnaire was administered to evaluate the dental care of each patient. Pearson χ2, Fisher exact, and Mann-Whitney tests were used for data analysis, with a level of significance of 5%. Results Marked overjet (75%) and anterior open bite (70%) were the most frequent occlusal alterations, and 15% had Class III disorders. Radiography visualized the presence of impacted teeth (75%) and prolonged retention of deciduous teeth (65%). Patients with enzyme replacement therapy had a lower average maximum protrusion (P = .033). A total of 75% of mothers said they had not been advised to take their children to the dentist and 10% of children had never been to the dentist. Conclusion Patients with mucopolysaccharidoses exhibited notable occlusal alterations, especially marked overjet and anterior open bite. Enzyme replacement therapy seems to influence the maximum protrusion of patients.

Background Oral mucositis has become a major dose-limiting toxicity of antineoplastic treatment. Aim The aim of this study was to evaluate the effect of photodynamic therapy (PDT) and low level laser therapy (LLLT) on the treatment of chemotherapy-induced mucositis in pediatric patients. Methods An open, controlled, and blind, randomized clinical trial was conducted with 29 patients, from 10 months to 18 years old, who were divided into two groups. Group A was submitted to photodynamic therapy (0.01% Methylene Blue and red laser, λ660 nm) with 3J energy per point; and Group B submitted to low level laser therapy (λ660 nm) with 1J energy per point. The results were evaluated by using the WHO and ChIMES mucositis scales. The Chi-square, Exact Fisher, Student’s-t and Mann-Whitney tests, and the mixed linear regression model were used for comparison between the groups, with the maximum error admitted of 5%. Results There was no difference between the groups as regards the number of sessions necessary for clinical cure of the oral lesions (p = 0.954) or reduction in pain reported by the patients (p = 0.258; p = 0.486). Within each group, however, there was significant reduction in pain (p = 0.032; p = 0.003). The number needed to treat (NNT) was 4.75. Conclusions PDT or LLLT could be used for treatment of oral mucositis in children/young patients. Each were well tolerated and presented satisfactory results in reducing pain associated with the lesion.

The study aimed to analyze the situation of Brazilian dental education considering the exceptionality of the COVID-19 pandemic. An observational and analytical study was conducted with two cross-sections, using questionnaires sent to all course coordinators in Brazil, in the 1st semester of 2020 and in March 2021. At onset of the pandemic, the institutions interrupted on-site activities. There was significant association between private institutions and offering remote lectures and using these resources before the pandemic. The public sector was associated with not teaching remote lectures and not using these resources previously. Public institutions had a greater degree of difficulty in the use and access to technologies for online activities by professors and students, as well as a lower degree of preparation in relation to biosecurity protocols to resume the clinical activities. Impacts were identified in different dimensions of dental education related to the development of practical activities and the establishment of new biosecurity protocols. Nearly all private courses did not suspend activities or did it for less than one month and resumed clinical or laboratory activities at some point during the surveyed period, while public institutions required an average of 5 months for such reorganization. The COVID-19 pandemic substantially increased the use of digital media in Brazilian dental education. From this assessment, there are financial limitations of the public sector to adapt the infrastructure to the requirements of the current biosecurity protocols. In general, students are receiving support from the institution and the coordinators identified negative impacts in different dimensions of dental education, notably in the establishment of new biosecurity protocols, adequacy in the physical structure and teaching-learning process.

This was a documentary research, using data from the student questionnaire of ENADE 2016. We analyzed the answers given by students who completed a public higher education course in Dentistry at a public institution in a Capital city in Northeastern Brazil. The IES data were filtered from the ENADE 2016 microdata worksheet, using the IES code, as obtained from the electronic system of the MEC (eMEC). The sociodemographic variables were used to characterize the profile of the graduates of the night course. The answers to the questionnaire were grouped into categories of positive, neutral or negative responses, for the three sections of the questionnaire: didactic-pedagogical organization, infrastructure and physical facilities of the course, and expansion of academic and professional development. The latter was analyzed comparatively between the night course(?)and full-time students of the same IEH, by using the Chi-square tests and Fisher's exact test applied with 95% confidence. The sociodemographic profile included a group of single, white, males, with a mean age of 28.9 years. In the Quality assessment of the didactic-pedagogical organization, physical infrastructure and facilities of the course, students' perceptions were positive for the majority of the subcomponents of the questionnaire. There was statistically significant difference between the night and full-time course students' responses, in terms of opportunities for extension and exchanges and / or international internship. The perception of the graduates, presented positive results, conferring a criterion of quality. The study indicated that the policy of expansion of higher education to include the night classes remained fragmented as extracurricular activities in the development of these (night) students at the public university.

Objective: To perform an in vitro analysis of antibacterial and antifungal potential of an alcoholic extract from the leaves of Guapira Graciliflora Mart. against oral microorganisms and determine its chemical composition. Material and Methods: A hydroalcoholic extract of the leaves form G. graciliflora was obtained through maceration, vacuum concentration and freeze-drying. Antibacterial and antifungal activities were evaluated against Streptococcus mutans , Streptococcus salivarius , Streptococcus oralis , Streptococcus parasanguinis , Streptococcus mitis and strains of Candida albicans using broth microdilution method. Phytochemical analysis determined the total phenolic compounds, protein concentration and total of sugars present in the extract . Results: G. Graciliflora demonstrated antifungal activity against the LM 11 and LM 410 clinical isolates of C. albicans (MIC 0.5 mg/mL and 2 mg/mL, respectively). The other microorganisms tested were resistant to the extract. The phytochemical analysis revealed 3% proteins, 13% total sugars and 17% phenolic compounds . Conclusion: G. Graciliflora has antifungal activity against clinical strains of C. albicans and exhibits proteins, sugars and phenolic compounds in its chemical composition.

Introduction Actinic cheilitis is a inflammatory condition affecting mainly the lower lip and it is caused by chronic and excessive exposure of the lips to the ultraviolet radiation in sunlight. Objective Identifying clinical and histopathologic characteristics in 40 cases histopathologically diagnosed as actinic cheilitis. In addition, to investigate possible associations between these aspects. Method Defined as an observational, transversal, retrospective and descriptive study, it registered data regarding age, gender, occupation, symptomatology, records of sun exposure, frequency of sunblock use, tabagism, skin color, clinical aspect and histopathological classification. The data was submitted to the chi square test of Pearson (p

Objective: To investigate the antifungal potential of A. colubrina , and its phytochemical characteristics, thermal profile and toxicity. Material and Methods: To assess potential antifungal activity, the technique of microdilution was used with the determination of the Minimum Inhibitory Concentration and Minimum Fungicidal Concentration, using standard species of Candida and recent clinical isolates of Candida albicans . Analyses of action of the extract were performed on the wall and cell morphology of C. albicans , of the interactive effect between the plant extract and nystatin on C. albicans through the checkerboard method, and of growth kinetics. The phytochemical screening was determined by spectrophotometry. The thermal profile was traced with the determination of thermogravimetric curves (TG) and differential scanning calorimetry (DSC). The toxicity was evaluated by the method of hemolysis. Results: The extract of A. colubrina showed a fungistatic potential against all bacteria tested and it acted by modifying the cellular morphology of C. albicans . There was a synergism between nystatin and the plant extract (FIC=0.375), and 53.18% of total polyphenols were determined. The TG curve showed the occurrence of three steps of thermal decomposition. None of the tested concentrations became the effective cytotoxic concentration. Conclusion: Further studies should be conducted to understand the efficacy and the mechanisms of action involved in the antifungal activity of the plant extract of A. colubrina in order to produce a new drug for the treatment of oral candidiasis.

Objective: To compare the rate of cell proliferation and expression of antiapoptotic protein Bcl-2 between drug-induced gingival overgrowth (DIGO) and clinical healthy gingiva (CHG) and to establish associations with histopathological features. Material and Methods: Twenty specimens of DIGO and 20 CHG specimens were submitted to morphological and immunohistochemical analysis by light microscopy. Cell proliferation (Ki-67) and the expression of Bcl-2 were evaluated in epithelial cells and spindle-shaped mononuclear cells of the connective tissue by establishing the labeling index (LI). Results: In epithelial tissue, the mean LI for Ki-67 was 17.2% in DIGO and 21.71% in CHG ( p = 0.137). The mean LIs for Bcl-2 in epithelial tissue were 14.67% and 10.24% in DIGO and CHG, respectively ( p = 0.026). In connective tissue, DIGO and CHG specimens exhibited low LIs for Ki-67 and Bcl-2, with mean values of less than 0.5% in both groups. No significant differences in the LIs for Ki-67 or Bcl-2 in epithelial tissue were observed according to the degree of collagenization, degree of vascularization and intensity of inflammatory infiltration ( p > 0.05). No significant correlations were observed between the LIs for Ki-67 and Bcl-2 ( p > 0.05). Conclusion: The present results suggest that the pathogenesis of DIGO does not involve increased proliferation or decreased apoptosis of fibroblasts. On the other hand, the morphological pattern of elongated epithelial cristae observed in DIGO could mainly be due to the inhibition of keratinocyte apoptosis and not to increased proliferation of these cells.

The aim of this double-blind randomized study was to evaluate the biocompatibility of resin-modified glass ionomer cements (RMGIC) by means of morphological and immunohistochemical analyses. RMGICs were selected and divided into four groups: Group CK (Crosslink Orthodontic Band Cement); Group RS (Resilience Light Cure Band Cement) Group RMO (RMO Band Cement), Group TP (Transbond Plus Light Cure Band), and Group C (Control-polyethylene). The materials were implanted in rat subcutaneous tissues, randomly selected for this study. After time intervals of 7, 15, and 30 days the tissues were submitted to morphological analysis. In immunohistochemical analysis, the immuno-marking of antibody CD68 was evaluated. The results obtained were statistically analyzed by the Kruskal-Wallis and Dunn tests (p < .05). In the morphological analysis after 7 days, Groups RS, RMO and TP showed more intense inflammatory infiltrate (p = .004) and only Group RMO presented greater intensity of multinucleated giant cells (p = .027). In the immunohistochemical analysis, Groups RMO and RS were observed to present a larger quantity of CD68+ (p = .004) in the time interval of 7 days and only Group RMO presented statistically significant difference for this parameter after 15 days (p = .026). In the time interval of 30 days, Group RMO presented the largest quantity of multinucleated giant cells (p < .004). The RMGICS Crosslink and Transbond Plus provided significantly better tissue biocompatibility than the Resilience and RMO Cements.

Introducao: O cisto periodontal lateral (CPL) e um cisto odontogenico de desenvolvimento incomum. Esta lesao acomete predominantemente a mandibula e e comumente observada lateralmente a raiz de um dente vital. Em raros casos, esta lesao pode permanecer mesmo ap o s a exodontia do dente associado e se assemelhar, radiograficamente, a um cisto residual. Objetivo: Relatar um caso incomum de CPL em maxila que mimetizava, radiograficamente, um cisto residual. Alem disso, serao abordadas suas caracteristicas clinico-patologicas, diagnostico diferencial e terapeutica para esta lesao. Relato do caso: Paciente de 76 anos, apresentava uma lesao nodular na regiao palatina de rebordo alveolar, na area correspondente aos dentes 13 e 14. O exame radiografico da regiao afetada demonstrou uma imagem radiolucida unilocular e bem delimitada. Sob a hipotese diagnostica de cisto residual, procedeu-se a enucleacao da lesao. Apos analise histopatologica, os achados microscopicos foram compativeis com CPL. Quatorze meses apos a remocao cirurgica da lesao, sinais clinicos ou radiograficos de recidiva nao foram constatados. Conclusao: Em virtude da possibilidade do CPL permanecer mesmo apos a exodontia do dente associado e se assemelhar, radiograficamente, a um cisto residual, o diagnostico desta lesao deve ser baseado nos achados histopatologicos e menor importância deve ser dada a sua localizacao adjacente ou lateral a raiz de um dente vital.

A 17-year-old male sought countryside hospital with throat pain and afebrile for 8 days, being prescribed cephalexin. Due to worsening of clinical condition with lingual protrusion and progressive loss of voice, he returned other times to the service, when he was referred for health center. He was transferred to emergency care unit and conducted to capital hospital for drainage of retropharyngeal abscess. Patient presented dyspnea, initiating treatment with dexamethasone, with clinical improvement of the tumor, but when suspended, the tumor grew up. He was transferred to intensive care unit and submitted to a computed tomography of skull, tracheostomy, gastrostomy, and excisional biopsy of the lesion that occupied all the oropharynx. He presented cardiorespiratory arrest, seizures, and respiratory infection. Results of biopsy and immunohistochemistry diagnosed Burkitt’s lymphoma. Patient was submitted to chemotherapy with regression of the lesion and return the tongue to the normal conditions.

Objective: To analyze the determinant clinical and histologic aspects in the establishment of the diagnosis of the glandular odontogenic cyst (GOC).Study Design: A cross-sectional study was performed in 2 oral pathology services. All slides of GOCs were reviewed and clinical data were obtained from the patient records. The determination of the diagnosis followed predetermined microscopic parameters according to the World Health Organization. Statistical analysis was performed in order to identify the predictive parameters for the diagnosis of GOC. Results: From the 9 patient cases of GOCs, 55.5% were male, with a mean age of 50.6 years, and 66.6% were located in the mandible. All cases presented with intraepithelial microcysts or duct-like spaces, clear or vacuolated cells, variable thickness of the cyst lining, and papillary projections into the lumen. Multiple compartments, surface eosinophilic cuboidal cells, and epithelial spheres or plaque-like thickenings were observed in 8 (88%) cases. Apocrine snouting of hobnail cells were present in 6 (66%), mucous goblet cells in 3 (33.3%), and cilia in only 1 (11%). Conclusion: The association between the predictive clinical and histopathological aspects for the diagnosis of this rare lesion is fundamental, since GOC has the potential to mimic other potentially more aggressive lesions.