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Recent research indicates that multiple sclerosis is preceded by a prodromal phase with elevated levels of serum neurofilament light chain (sNfL), a marker of axonal injury. The effect of environmental risk factors on the extent of axonal injury during this prodrome is unknown. Human herpesvirus 6A (HHV-6A) is associated with an increased risk of developing multiple sclerosis. The objective of this study was to determine if HHV-6A serostatus is associated with the level of sNfL in the multiple sclerosis prodrome, which would support a causative role of HHV-6A. A nested case-control study was performed by crosslinking multiple sclerosis registries with Swedish biobanks. Individuals with biobank samples collected before the clinical onset of multiple sclerosis were included as cases. Controls without multiple sclerosis were randomly selected, matched for biobank, sex, sampling date and age. Serostatus of HHV-6A and Epstein-Barr virus was analysed with a bead-based multiplex assay. The concentration of sNfL was analysed with single molecule array technology. The association between HHV-6A serology and sNfL was assessed by stratified t-tests and linear regressions, adjusted for Epstein-Barr virus serostatus and sampling age. Within-pair ratios of HHV-6A seroreactivity and sNfL were calculated for each case and its matched control. To assess the temporal relationship between HHV-6A antibodies and sNfL, these ratios were plotted against the time to the clinical onset of multiple sclerosis and compared using locally estimated scatterplot smoothing regressions with 95% confidence intervals (CI). Samples from 519 matched case-control pairs were included. In cases, seropositivity of HHV-6A was significantly associated with the level of sNfL (+11%, 95% CI 0.2-24%, P = 0.045) and most pronounced in the younger half of the cases (+24%, 95% CI 6-45%, P = 0.007). No such associations were observed among the controls. Increasing seroreactivity against HHV-6A was detectable before t

Background. Web applications are a more significant part of our digital experience, and the number of users keeps continuously growing. Social media alone accounts for more than half of the world’s population. Therefore these applications have become a lucrative target for attackers, and we have seen several attacks against them. One such example saw attackers manage to compromise a twitter account [15], leading to false information being published, causing the New York stock exchange to drop 150 points, erasing 136 billion dollars in equity market value. There are methods to protect web applications, such as web application firewalls or content security policies. Still, another candidate for defending these applications is Host-based Intrusion Detection Systems (HIDS). This study aims to assess the efficiency of these HIDS when defending against web applications. Objectives. The main objective of the thesis is to create an efficiency evaluating model for a HIDS when protecting web applications. Additionally, we will test two open-source HIDS against web applications built to emulate a vulnerable environment and measure these HIDS efficiencies with the model mentioned above. Methods. To reach the objectives of our thesis, a literature review regarding what metrics to evaluate the efficiency of a HIDS was conducted. This allowed us to construct a model for which we evaluated the efficiency of our selected HIDS. In this model, we use 3 categories, each containing multiple metrics. Once completed, the environment hosting our vulnerable applications and their HIDS was set up, followed by the attacks of the applications. The data generated by the HIDS gave us the data required to make our efficiency evaluation which was performed through the lens of the previously mentioned model. Results. The result shows a low overall efficiency from the two HIDS when regarding the category attack detection. The most efficient of the two could be determined. Of the two evaluated, Wazuh

Background: Infection with human herpesvirus 6A (HHV-6A) has been suggested to increase multiple sclerosis (MS) risk. However, potential interactions between HHV-6A and environmental/lifestyle risk factors for MS have not previously been studied. Methods: We used two Swedish population-based case-control studies comprising 5993 cases and 5995 controls. Using logistic regression models, subjects with different HHV-6A antibody levels, environmental exposures, and lifestyle habits were compared regarding MS risk, by calculating odds ratios (ORs) with 95% confidence intervals (CIs). Potential interactions between high HHV-6A antibody levels and common environmental exposures and lifestyle factors were evaluated on the additive scale. Results: High HHV-6A antibody levels were associated with increased risk of developing MS (OR = 1.5, 95% CI = 1.4–1.6). Regarding MS risk, significant interactions were observed between high HHV-6A antibody levels and both smoking (attributable proportion (AP) = 0.2, 95% CI = 0.1–0.3), low ultraviolet radiation (UVR) exposure (AP = 0.3, 95% CI = 0.1–0.4), and low vitamin D levels (AP = 0.3, 95% CI = 0.0–0.6). Conclusion: High HHV-6A antibody levels are associated with increased MS risk and act synergistically with common environmental/lifestyle risk factors for MS. Further research is needed to investigate potential mechanisms underlying the interactions presented in this study.

Background and purpose: Infections with human herpesvirus 6A (HHV‐6A) and Epstein–Barr virus (EBV) have been linked to multiple sclerosis (MS) development. For EBV, late infection has been proposed as a risk factor, but serological support is lacking. The objective of this study was to investigate how age affects the EBV and HHV‐6A associated risks of developing MS. Methods: In this nested case–control study, Swedish biobanks were accessed to find pre‐symptomatically collected blood samples from 670 individuals who later developed relapsing MS and 670 matched controls. A bead‐based multiplex assay was used to determine serological response against EBV and HHV‐6A. Conditional logistic regression was used to calculate odds ratios and 95% confidence intervals. Results: Seropositivity against EBV exhibited a pattern where associations switched from a decreased risk of developing MS in the group below 20 years of age to an increased risk amongst individuals aged 20–29 and 30–39 years (p for trend 0.020). The age of transition was estimated to be 18.8 years. In contrast, HHV‐6A was associated with increased MS risk in all age groups (total cohort odds ratio 2.1, 95% confidence interval 1.6–2.7). Conclusions: This study suggests EBV infection after adolescence and age independent HHV‐6A infection as risk factors for MS.

Background and purpose Epstein-Barr virus (EBV) and human herpesvirus 6A (HHV-6A) are associated with increased risk of multiple sclerosis (MS). Conversely, infection with cytomegalovirus (CMV) has been suggested to reduce the risk of MS but supporting data from presymptomatic studies are lacking. Here, it was sought to increase the understanding of CMV in MS aetiology. Methods A nested case-control study was performed with presymptomatically collected blood samples identified through crosslinkage of MS registries and Swedish biobanks. Serological antibody response against CMV, EBV and HHV-6A was determined using a bead-based multiplex assay. Odds ratio (OR) with 95% confidence interval (CI) for CMV seropositivity as a risk factor for MS was calculated by conditional logistic regression and adjusted for EBV and HHV-6A seropositivity. Potential interactions on the additive scale were analysed by calculating the attributable proportion due to interaction (AP). Results Serum samples from 670 pairs of matched cases and controls were included. CMV seropositivity was associated with a reduced risk for MS (OR = 0.70, 95% CI 0.56-0.88, p = 0.003). Statistical interactions on the additive scale were observed between seronegativity for CMV and seropositivity against HHV-6A (AP 0.34, 95% CI 0.06-0.61) and EBV antigen EBNA-1 (amino acid 385-420) at age 20-39 years (AP 0.37, 95% CI 0.09-0.65). Conclusions Cytomegalovirus seropositivity is associated with a decreased risk for MS. The protective role for CMV infection in MS aetiology is further supported by the interactions between CMV seronegativity and EBV and HHV-6A seropositivity., Funding Agencies|Swedish Research CouncilSwedish Research CouncilEuropean Commission [2015-02419, 2018-03918]; Visare Norr Fund, Northern County Councils Regional Federation [940405]; Research and Development Unit, Region Jamtland Harjedalen [JLL-939768]; Margaretha af Ugglas stiftelse; Swedish Neuro Foundation; MS Research fund; Swedish Research CouncilSwedish Research CouncilEuropean Commission; Swedish Brain Foundation; Horizon 2020 MultipleMS Grant [733161]

eWOM är en viktig kommunikationsmetod på internet idag där konsumenter kan dela med sig av sina åsikter, erfarenheter och information angående företaget eller dess produkter genom online recensioner, som då finns lätt tillgängligt för andra att läsa. Detta har visat sig genom den granskade forskningen att eWOM har en betydande roll för hur konsumenters köpintention påverkas. Det finns olika faktorer inom eWOM som kan vara anledningen till att konsumenter idag väljer att läsa online recensioner innan ett köp. Denna studie fokuserar på faktorerna trovärdighet, kvalitet och kvantitet. Online recensioner kan även finnas på olika plattformar men denna studie har avgränsats detta till e-handelsplattformar, där företag säljer sina produkter eller tjänster. Den granskade forskningen från olika länder visar på att eWOM påverkar deras konsumenter, men det upptäcks en avsaknad av den svenska befolkningen. Detta leder till att syftet med denna studie är att undersöka om upplevd trovärdighets, kvalitets och kvantitets faktorer inom eWOM har en påverkan på svenska konsumenters köpintention på e-handelsplattformar. eWOMs direkta påverkan på köpintentionen med hjälp av den valda inriktningen utgör det teoretiska ramverk som denna studie grundar sig i. För att kunna svara på syftet så genomförs studien genom en kvantitativ forskningsmetod för att försöka generalisera om de svenska konsumenterna påverkas av eWOM. Datainsamlingen utförs genom en digital enkät som publicerades på två Facebook grupper med en inriktning på möbler och heminredning. Enkäten utformades efter påståenden där respondenterna skulle ta ställning och 102 svar kom in. Resultatet av datainsamlingen visar på att de svenska konsumenterna påverkas av eWOM i form av online recensioners trovärdighet, kvalitet och kvantitet. Resultatet visar även på att kvalitet anses vara den faktor som har störst påverkan på konsumentens köpintention. Vilket visar att de hypoteser som ställs i studien accepteras. De tre faktorerna som, eWOM is an important communication method on the internet today where consumers can share their opinions, experiences and information regarding the company or its products through online reviews, which are then easily accessible for others to read. It has been shown through the examined research that eWOM has a significant role in how consumers' purchase intentions are affected. There are various factors within eWOM that may be the reason why consumers today choose to read online reviews before making a purchase. This study will focus on the factors of credibility, quality, and quantity. Online reviews can also be found on various platforms, but this study will limit this to e-commerce platforms, where companies sell their products or services. The research examined from different countries shows that eWOM affects their consumers, but a lack of the Swedish population is detected. This leads to the purpose of this study being to investigate whether perceived credibility, quality, and quantity factors within eWOM have an impact on Swedish consumers' purchase intention on e-commerce platforms. eWOM’s direct impact on the purchase intention with the help of the chosen focus constitutes the theoretical framework on which this study will be based. To answer the purpose, the study is conducted through a quantitative research method to try to generalize whether Swedish consumers are affected by eWOM. The data collection is carried out through a digital survey that was published on two Facebook groups with a focus on furniture and home furnishings. The questionnaire was designed according to statements where the respondents would take a stand and 102 responses were received. The results of the data collection show that Swedish consumers are affected by eWOM in the form of online reviews' credibility, quality, and quantity. The results also show that quality is considered to be the factor that has the greatest impact on the consumer's purchase intention. Which shows that the

Puumala orthohantavirus causes hemorrhagic fever with renal syndrome (HFRS) characterized by acute kidney injury (AKI), an abrupt decrease in renal function. Creatinine is routinely used to detect and quantify AKI; however, early AKI may not be reflected in increased creatinine levels. Therefore, kidney injury markers that can predict AKI are needed. The potential of the kidney injury markers urea, cystatin C, α1-microglobulin (A1M) and neutrophil gelatinase-associated lipocalin (NGAL) to detect early AKI during HFRS was studied by quantifying the levels of these markers in consecutively obtained plasma (P) and urine samples (U) for 44 HFRS patients. P-cystatin C and U-A1M levels were significantly increased during early HFRS compared to follow-up. In a receiver operating characteristic (ROC) curve analysis, P-cystatin C, U-A1M and P-urea predicted severe AKI with area under the curve 0.72, 0.73 and 0.71, respectively, whereas the traditional kidney injury biomarkers creatinine and U-albumin did not predict AKI. Nearly half of the HFRS patients (41%) fulfilled the criteria for shrunken pore syndrome, which was associated with the level of inflammation as measured by P-CRP. P-cystatin C and U-A1M are more sensitive and earlier markers compared to creatinine in predicting kidney injury during HFRS.

Ecosystems are linked by the movement of organisms across habitat boundaries and the arrangement of habitat patches can affect species abundance and composition. In tropical seascapes many coral reef fishes settle in adjacent habitats and undergo ontogenetic habitat shifts to coral reefs as they grow. Few studies have attempted to measure at what distances from nursery habitats these fish migrations (connectivity) cease to exist and how the abundance, biomass and proportion of nursery species change on coral reefs along distance gradients away from nursery areas. The present study examines seascape spatial arrangement, including distances between habitats, and its consequences on connectivity within a tropical seascape in Mozambique using a seascape ecology approach. Fish and habitat surveys were undertaken in 2016/2017 and a thematic habitat map was created in ArcGIS, where cover and distances between habitat patches were calculated. Distance to mangroves and seagrasses were significant predictors for abundance and biomass of most nursery species. The proportions of nursery species were highest in the south of the archipelago, where mangroves were present and decreased with distance to nurseries (mangroves and seagrasses). Some nursery species were absent on reef sites farthest from nursery habitats, at 80 km from mangroves and at 12 km from seagrass habitats. The proportion of nursery/non-nursery snapper and parrotfish species, as well as abundance and biomass of seagrass nursery species abruptly declined at 8 km from seagrass habitats, indicating a threshold distance at which migrations may cease. Additionally, reefs isolated by large stretches of sand and deep water had very low abundances of several nursery species despite being within moderate distances from nursery habitats. This highlights the importance of considering the matrix (sand and deep water) as barriers for fish migration.

Human herpesvirus (HHV)-6A or HHV-6B involvement in multiple sclerosis (MS) etiology has remained controversial mainly due to the lack of serological methods that can distinguish the two viruses. A novel multiplex serological assay measuring IgG reactivity against the immediate-early protein 1 from HHV-6A (IE1A) and HHV-6B (IE1B) was used in a MS cohort (8,742 persons with MS and 7,215 matched controls), and a pre-MS cohort (478 individuals and 476 matched controls) to investigate this further. The IgG response against IE1A was positively associated with MS (OR = 1.55, p = 9 × 10-22), and increased risk of future MS (OR = 2.22, p = 2 × 10-5). An interaction was observed between IE1A and Epstein-Barr virus (EBV) antibody responses for MS risk (attributable proportion = 0.24, p = 6 × 10-6). In contrast, the IgG response against IE1B was negatively associated with MS (OR = 0.74, p = 6 × 10-11). The association did not differ between MS subtypes or vary with severity of disease. The genetic control of HHV-6A/B antibody responses were located to the Human Leukocyte Antigen (HLA) region and the strongest association for IE1A was the DRB1*13:01-DQA1*01:03-DQB1*06:03 haplotype while the main association for IE1B was DRB1*13:02-DQA1*01:02-DQB1*06:04. In conclusion a role for HHV-6A in MS etiology is supported by an increased serological response against HHV-6A IE1 protein, an interaction with EBV, and an association to HLA genes.

Introduction: Haemorrhagic fever with renal syndrome (HFRS) is characterized by fever, hypotension, vascular leakage, thrombocytopenia and renal failure. HFRS in Sweden is caused by the Puumala hantavirus and is spread by viral-infested droppings from bank voles. The health care system has little to offer these patients since there is no antiviral treatment and as of yet there is no vaccine prophylaxis available. We previously showed that a marker of endothelial glycocalyx degradation (Syndecan-1) was associated with disease severity and disseminated intravascular coagulation during HFRS (Connolly-Andersen et al., 2014, Open Forum Infect Dis.). Methods: We analysed the levels of other endothelial glycocalyx degradation markers (heparan sulfate, soluble thrombomodulin, albumin), a potential “sheddase”: Matrix Metalloproinase 9 (MMP9) and neutrophil activation/tissue damage (neutrophil gelatinase-associated lipocalin, NGAL) in patient plasma from 44 HFRS patients collected consecutively following disease onset. We used the generalized estimating equation to analyse the association between endothelial glycocalyx degradation, MMP9 levels, neutrophil activation/tissue damage and HFRS disease outcome (need for oxygen, transfusion with blood components, need for intensive care unit (ICU) treatment and renal damage). Results: 44 HFRS patients were included in this study (29 females (66%)); need for oxygen: 11 (25%); transfusion with blood components: 3 (7%) and stay at ICU: 2 (5%)). The levels of MMP9 were significantly associated with all markers of endothelial glycocalyx degradation. Neutrophil activation/tissue damage (NGAL) was also significantly associated with MMP9 and endothelial glycocalyx degradation markers (apart from albumin (p = 0.053). In addition degradation of endothelial glycocalyx associated with HFRS disease outcome. Conclusion: Degradation of the endothelial glycocalyx could be a potential mechanism of HFRS pathogenesis, and potentially MMP9 could contri, Supplement 1, meeting abstract 73.

Introduktion Den interna revisorn antas ha bättre insyn i företaget än den externa. Enligt agentteori maximerar internrevisorn sin egen nytta, vilket ifrågasätter dennes oberoende. Dagens forskning är delad i två perspektiv där den interna revisionen och de externa revisionskostnaderna har ett positivt eller negativt samband. Den rådande trenden med ökad intern revision och kontroll i samband med den nya kontext som skapats genom de under 2000-talet införda regelverken motiverar och aktualiserar studien. Syfte Syftet med denna studie är att förklara hur den interna revisionen påverkar kostnaden för den externa revisionen i svenska noterade bolag. Metod Studien har en kvantitativ forskningsstrategi och en deduktiv forskningsansats. Genom dokumentstudier har data för svenska noterade företag samlats in och med hjälp av en regressionsmodell analyserats. Operationalisering har skett i enlighet med tidigare forskning och internrevisionens förekomst har mätts med en dummyvariabel. Slutsats Studiens resultat visar att internrevisionens förekomst har ett starkt signifikant positivt samband med kostnaden för den externa revisionen. Studien finner att företag med internrevision får högre revisionskostnader, men att de bakomliggande orsakerna kan vara krav på ökade kontroller. Tidigare forskning bekräftar resonemanget och att efterfrågan på ökad kontroll leder till ökade investeringar i både den interna och externa revisionen. Studiens resultat implicerar att internrevisionen används av företagsledningen för att signalera förtroende till ägarna., Introduction The internal auditor is assumed to have a greater insight in the firm than the external auditor. Agency theory tells us that the internal auditor maximizes his own utility, which questions his independence. The current research is divided into two perspectives where the internal audit and the cost of the external audit has a positive or a negative relationship. The prevailing trend of increased internal audit and control together with the new context created in the 21th century with introduced regulations motivates and actualizes this study. Purpose The purpose of this study is to explain how the internal audit impacts the cost of the external audit in swedish listed firms. Method This study has a quantitative research strategy and a deductive research approach. Data from swedish listed firms has been collected through studies of documents and analyzed with a linear regression. Operationalization has been made in accordance with previous research and the presence of internal audit has been measured with a dummy variable. Conclusion The result of this study shows that the presence of internal audit has a strongly significant positive relationship with the cost of the external audit. The study finds that firms with internal audit increase their audit costs, but that underlying reasons might be demand for greater control. Previous research confirms the argument and that demand for greater control leads to greater investments in both internal and external audit. The result of this study implies that internal audit is used by management to signal trust to the shareholders.

Sammanfattning Examensarbetets titel: Intern kontroll i byggprojekt Seminariedatum: 26 maj 2014 Ämne/kurs: FEKN90, Examensarbete på Civilekonomprogrammet, 30 HP (30 ECTS) Författare: Rasmus Gustafsson och Simon Lundgren Handledare: Per Magnus Andersson Nyckelord: Intern kontroll, byggprojekt, COSO, agentteori, corporate governance Syfte: Syftet med denna uppsats är att beskriva och analysera hur svenska byggföretag arbetar med intern kontroll i byggprojekt. Metod: I studien används en kvalitativ metod tillsammans med en multipel fallstudie bestående av sex fall. Teoretiska perspektiv: Uppsatsen utgår från teoretiska perspektiv inom områdena agentteori, corporate governance, intern kontroll, internrevision, COSO-ramverket samt projektledning. Empiri: Uppsatsens empiri har sin utgångspunkt i sju semistrukturerade intervjuer med representanter från Flex Interior Systems AB, Moelven Eurowand AB, Thage Andersson Byggnads AB, JM AB, NCC Roads AB och Skanska Sverige AB. Resultat: Studiens resultat visar att det finns skillnader i hur olika byggföretag arbetar med intern kontroll i byggprojekt. Resultaten stödjer tidigare forskning som bland annat indikerar att företagens storlek har påverkan på deras arbete inom området bolagsstyrning och intern kontroll.

Ecosystems are linked by the movement of organisms across habitat boundaries and the arrangement of habitat patches can affect species abundance and composition. In tropical seascapes many coral reef fishes settle in adjacent habitats and undergo ontogenetic migrations to coral reefs as they grow. Few studies have attempted to measure at what distances from nursery habitats these fish migrations (connectivity) cease to exist and how the abundance, biomass and proportion of nursery species change on coral reefs along distance gradients away from nursery areas. The present study examines seascape arrangement, including distances between habitats, and its consequences on connectivity within a tropical seascape in Mozambique using a seascape ecology approach. Fish and habitat surveys were undertaken in 2016/2017 and a thematic habitat map was created in ArcGIS, where cover and distances between habitat patches were calculated. Distance to mangroves, seagrasses and channels were significant for most nursery species and both abundance, biomass and proportion of nursery species were highest in the south of the archipelago, where mangroves were present and decreased with distance to nurseries (mangroves and seagrasses). Some nursery species were absent on reef sites furthest from nursery habitats (80km) and at 8km from seagrass habitats the proportion of nursery/non-nursery species as well as abundance and biomass of seagrass nursery species drastically changed, indicating a threshold distance at which migrations may cease. A similar pattern was found between 3 and 6 km from channels. Threshold distances were found where ontogenetic movement from nurseries to reefs appeared to cease and these distances differed between fish families. Isolation and arrangement of nursery habitats were also found to structure adult fish communities on reefs, highlighting the importance of considering the matrix (sand and deep water) as barriers for fish migration.