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The aim of this paper is to present the design and application of an electrooculogram (EOG) based on an efficient human--computer interface (HCI). Establishing an alternative channel without speaking and hand movements is important in increasing the quality of life for the handicapped. EOG-based systems are more efficient than electroencephalogram (EEG)-based systems in some cases. By using a realized virtual keyboard, it is possible to notify in writing the needs of the patient in a relatively short time. Considering the biopotential measurement pitfalls, the novel EOG-based HCI system allows people to successfully communicate with their environment by using only eye movements. Classifying horizontal and vertical EOG channel signals in an efficient interface is realized in this study. The new system is microcontroller based, with a common-mode rejection ratio of 88 dB, an electronic noise of 0.6 µV (p-p), and a sampling rate of 176 Hz. The nearest neighborhood algorithm is used to classify the signals, and the classification performance is 95%. The novel EOG-based HCI system allows people to successfully and economically communicate with their environment by using only eye movements. [ABSTRACT FROM AUTHOR]