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Copper(i) catalyzed alkyne azide cycloaddition is the quintessential example of ‘Click Chemistry’, provides an adaptable platform for the synthesis of nanogels for sustained drug release at targeted sites owing to their better biocompatibility.

The unique solvatochromic attitude of an analyte owing to its coordination with metal ions in solvents of different polarities is challenging. Herein, we introduce two new solvatochromic 4-(pentan-3-yl) benzaldehyde-based triazolyl silatrane probes (

1-Adamantanamine based organosilanes 4a–d have been synthesized and possessed selectivity towards Sn2+ ions only and serve as a colorimetric/fluorimetric dual-channel probe. The turn-on fluorescence has been marked on interaction with Sn2+ ions.

This article highlights the design and synthesis of Schiff base of veratraldehyde based organosilatranes and organosilocanes (3a-3c) and these were meticulously characterized with the aid of NMR (1H and 13C) and mass spectroscopic techniques. Moreover, the compound VBS (3a) was fabricated over silica nanoparticles by one-pot method which was enrichly authenticated by IR, XRD, EDX, TGA, and FE-SEM analysis. The colorimetric and fluorimetric detection of VBS and its hybrid silica nanoparticles (V-NPs) revealed their significant sensorial ability towards Cu2+ and Fe3+ over other relevant competitive metal ions. Interestingly, the binding of sensor VBS and V-NPs with Cu2+ and Fe3+ ions manifested an instant color change from yellow to light green and colorless, respectively in day light which is detectable by “naked-eye” and fluorescent turn-off response in UV-light. The results demonstrated that the organic-inorganic nanohybrids exhibited better sensitivity, greater affinity and lower limit of detection leading to better response time than the parent VBS towards Cu2+ and Fe3+ ions. The computational analysis using DFT approach was annotated to get an insight into the complexation mode of VBS with Cu2+ ion and Fe3+ ion. In addition to this, anti-oxidant properties were also investigated for compounds 3a-3c. Altogether, these findings paved the way for the design and synthesis of dual metal ion sensor.

A new set of morpholine analogue Schiff base linked organosilanes (5a–5c) was prepared.

This article includes the synthesis and characterization of tetrazole-allied organosilane and organosilatrane. The tetrazole-allied silatrane was explored for molecular docking and optical aspects.

This paper synthesizes triazole-attached 2-aminofluorene-based organosilane for sensing Fe3+ ion using UV-Vis and fluorescence. Probe 6a's inhibitory effect on the leishmania protein was studied. DFT explained 6a's complexation with Fe3+ ion.

Copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) is a resourceful and stereospecific methodology that has considerably yielded promising 1,2,3-triazole-appended "click" scaffolds with the potential for selective metal ion recognition. Based on "click" methodology, this report presents a chemosensor probe (TCT) based on 4

The present study aims to produce nanocomposites of silica based organosilane as sensitive and selective fluorescent sensor for the recognition of 2,4 dichlorophenoxyacetic acid (2,4-D). Hydrazone tethered triazole functionalized organosilane has been synthesized by the condensation reaction of 4-hydroxybenzaldehyde and phenyl hydrazine followed by Cu(I) catalysed cycloaddition of azide with alkyne. The prepared compound has been further grafted over silica surface and the synthesized materials were characterized by FT-IR, NMR (

The nucleophilic aromatic substitution reactions of 4,6-dinitroisoindoline-1,3-dione with 1,2,3-triazole isomers, i.e., 1H-1,2,3-triazole and 2H-1,2,3-triazole, have been investigated theoretically using DFT/B3LYP calculations employing 6-31G(d,p) basis set in gas phase as well as in solvent phase. The computational studies have supported the formation of transition states via one-step concerted mechanism for the nucleophilic aromatic displacement of nitro groups with 1,2,3-triazoles rather than intermediate formation via two-step addition-elimination mechanism. The amination of 4,6-dinitroisoindoline-1,3-dione with 1,2,3-triazole isomers have revealed regioselectivity of peri-attack despite sterically favorable para-attack. The regioselectivity is attributed to the stabilization of the transition state through intra-molecular hydrogen bond C-H···O=C. This work presents the role of C-H bond as an effective hydrogen bond donor. The molecular interactions through hydrogen bonding have been investigated using AIM method. This work shall result in the synthesis of new regioselective 1,2,3-triazole-derived phthalimide compounds possessing potential biological candidature.

Excess Al3+ ions are considered toxic to living organisms. Keeping the harmful effects of excess Al3+ metal ions in mind, a new Schiff base = functionalized silatrane as a potential chemo-sensor for the recognition of aluminium metal ions with high selectivity and specificity has been designed and well characterized using various characterization techniques such as IR, 1H NMR, 13C NMR, TGA, and mass spectroscopy. The chemo-sensing properties were studied using ultraviolet and fluorescence spectroscopy. The absorption spectrum of the synthesized receptor was changed only by the addition of Al3+ ions, while other ions showed negligible changes. The 1 : 1 stoichiometric ratio of the chemo-sensor 4b with Al3+ was confirmed by Job's plot and linearity in the B–H plot. The limit of detection observed for Al3+ ions was 2.273 × 10−7 M and 9.8 × 10−9 M from ultraviolet and fluorescence spectroscopy, respectively. The binding constant from the B–H plot and the Stern–Volmer quenching constant were found to be 0.2279 × 106 M−1 and 2.7 × 106 M−1, respectively. These results explain the potential chemo-selectivity of the receptor 4b towards Al3+ metal ions, which may be useful for biological and industrial purposes.

Organosilicon chemistry is appraised as the trunk of coalescence and structural manoeuvres of moieties. Schiff base compounds are popular auxiliary scaffolds having vast applications in the fields of biological activities, organic synthesis, sensing, catalysis and agriculture. Here, in this article we have presented the synthesis, structural elucidation and photophysical aspects of 1,2,3-triazole allied Schiff base functionalized silanes (5a–5d) and silatranes (6a–6d). A two-step approach was followed to synthesize the desired products and the compounds were confirmed by NMR (1H and 13C) and mass spectrometry. The silane 5a and silatrane 6a were investigated by density functional theory and their photophysical potential via absorption and emission spectroscopy. The probes were found to be specific and selective only for Sn2+ metal ions. The limit of detection values were found to be 0.86 × 10−8 M and 0.58 × 10−8 M for 5a & 6a, respectively, from absorption spectroscopy. The limit of detection values from emission spectroscopy were calculated as 1.3 × 10−9 M and 0.64 × 10−9 M for 5a & 6a, respectively. Furthermore, the high binding efficiency of Sn(II) with sensors 5a & 6a was confirmed by the high association constants (Ka) from the linear calibration curves as 4.6 × 106 M−1 and 0.15 × 107 M−1, respectively, for 5a & 6a. The Stern–Volmer plot was explored to calculate the Stern–Volmer constants (Ksv), which were found to be 21.66 × 107 M−1 and 30.39 × 107 M−1. A Job's plot confirmed the 1 : 1 stoichiometric ratio of host:guest in both 5a & 6a.

The present article reports the synthesis and structural characterization of a triazole appended isatin linked silane-based sensor using a highly efficient click chemistry approach. The yellow-coloured solution of the highly selective chemosensor turned red in the presence of Ag+ ions and a red shift in the absorption spectra was also observed during the addition of these ions. IR spectroscopic studies support the metal ion binding with organosilanes in the cavity created by the carbonyl group of isatin, the nitrogen atom of the triazole ring and the Si–O bond of silane. Furthermore, the sensing application was enhanced by the immobilization of the ligand on the surface of iron oxide silica nanoparticles and the resulting silica surfaced nanocomposites were characterized using various techniques. B–H plots and calibration curves were employed to measure the association constants and limits of detection, respectively, of the synthesized ligands and their magnetic nanoparticles. The nanohybrids demonstrate a greater binding potential to Ag+ ions. In addition, the synthesized organosilanes were investigated for cytotoxicity using the MTT assay, and the antioxidant activity was measured by decolouration of ABTS˙+.

The present work reports for the first time the preparation of aryl–alkyl ether functionalized silatrane for the selective recognition of Al3+ ions using the cyclic voltammetry technique. The synthesis was achieved through a condensation reaction followed by transesterification methodology to obtain organosilatranes in good yields. The prepared compounds were well characterized by IR, NMR (1H and 13C) and mass spectral analysis and the structure of one of the molecules was further confirmed by X-ray crystallography, which showed a triclinic crystal system with a P space group. The electrochemical behaviour was studied by employing square wave voltammetry (SWV) using a gold electrode to investigate the receptor action of the synthesized organosilatranes. A detection limit of 48.9 nM and competitive binding results suggest the significant receptor potential of organosilatranes for the detection of Al3+ ions. Moreover, the real time application of the prepared sensors was confirmed by the determination of Al3+ ions in tea leaves.

Herein, we report a new chemosensor based on 1, 2, 3-triazole containing salicylimine linked organosilocane for the detection of Ce3+ ions in aqueous solution. This receptor was efficiently prepared by employing condensation reaction followed by Cu(I) catalysed alkyne-azide cycloaddition methodology. All the prepared compounds were characterized by IR, 1H NMR, 13CNMR, CHN analysis and mass spectroscopy. The sensitivity of the synthesized sensor towards Ce3+ ions is preeminent with detection limit as low as 1.44 μM. Density functionalised theory based quantum mechanical calculation suggest the molecular geometry of the organosilocane (host) to make the stable complex with cerium (guest). Moreover, chemosensing ability in aqueous solution facilitates the receptor to be used for detection in real samples.

The present article includes the generation of aromatic Schiff base tethered organosilatranes via two step synthetic pathways starting from anthracene-10-carbaldehyde and 1H-indole-3-carbaldehyde. The synthesis was achieved by employing condensation reaction followed by transesterification methodology. The prepared organosilatranes containing aromatic schiff based ligands were structurally authenticated using spectroscopic techniques such as FT-IR, NMR and mass analysis. The prepared compounds were also scrutinized for in silico physiochemical properties via Molininspiration and ADMET software and the results revealed their good biological potential for drug discovery.

In the extensive terrain of catalytic procedures for the synthesis of organic molecules, metal–organic frameworks (MOFs) as heterogenous catalysts have been investigated in a variety of chemical processes, including Friedel–Crafts reactions, condensation reactions, oxidations, and coupling reactions, and utilized owing to their specific properties such as high porosity, tuneability, extraordinary catalytic activity, and recyclability. The eminent copper-tailored MOF materials can be exceptionally dynamic and regioselective catalysts for click reactions (1,3-dipolar cycloaddition reaction). Considering the fact that Cu(I)-catalyzed alkyne–azide cycloaddition (CuAAC) reactions can be catalyzed by several other copper catalysts such as Cu (II)-β-cyclodextrin, Cu(OAc)2, Fe3O4@SiO2, picolinimidoamide–Cu(II) complex, and Cu(II) porphyrin graphene, the properties of sorption and reusability, as well as the high density of copper-MOFs, open an efficient and robust pathway for regimented catalysis of this reaction. This review provides a comprehensive description and analysis of the relevant literature on the utilization of Cu-MOFs as catalysts for CuAAC ‘click’ reactions published in the past decade.

This article presents the design and synthesis of a new series of N-heterocyclic unsymmetrical organosilatranes starting from carboxaldehydes and [3-(2-aminoethylamino)propyl]trimethoxysilane. The molecular structures of the desired organosilatranes were confirmed by various characterization techniques such as elemental analysis, FTIR, NMR (1H and 13C) and mass spectroscopy. The prepared compounds were evaluated for their cationic chemosensing activities and the recognition studies show considerable variations in the intensity and λmax values of absorption and emission spectra on addition of Sn2+ ions. Further immobilization of N-heterocyclic unsymmetrical organosilatranes was done on a magnetic silica surface and the resultant nanohybrids were identified by numerous analytical techniques viz., FTIR, TGA, XRD, SEM, VSM and BET. The comparative detection studies of the nanoparticles with silatranes showed better Sn2+ ion binding ability. Moreover, the pharmacokinetic profile of the synthesized compounds was analysed using MOLINSPIRATION and ADMET software and it gave auspicious results that triggered the investigation of the cytotoxicity and total antioxidant activity (TAA) of these molecules.