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11. [Aggravation by halomethanes of damages in isolated erythrocyte membranes photosensitized by porphyrins].

Author

Tsvirko MP, Vorobeĭ AV, and Gurinovich VV

Subjects
Drug Synergism, Erythrocyte Membrane metabolism, Erythrocyte Membrane radiation effects, Humans, In Vitro Techniques, Lipid Peroxidation drug effects, Lipid Peroxidation radiation effects, Membrane Lipids metabolism, Oxidation-Reduction, Spectrometry, Fluorescence, Zinc, Carbon Tetrachloride pharmacology, Erythrocyte Membrane drug effects, Light, Metalloporphyrins pharmacology, Photosensitizing Agents pharmacology, Trihalomethanes pharmacology
Abstract

It was found that halogen methanes (CCl4, CHBr3) enhance the destruction of protein tryptophanyls and lipid peroxidation photosensitized by Zn-tetraphenylporphin and Zn-tetramethylpyridylporphyrin in isolated erythrocyte membranes. It was shown that this effect is due to photoinduced electron transport from Zn-porphyrins to halogen methanes with the formation of highly reactive halogenmethyl radicals. The hydrophilic Zn-tetramethylpyridylporphyrin is more active at the photosensition of damage to membrane proteins, whereas the hydrophobic Zn-tetraphenylporphin is more effective in lipid peroxidation.

Published
2002

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