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3. Subthalamotomy for Parkinson’s Disease

Author

Obeso, J. A., Alvarez, L., Macias, R., Pavon, N., Lopez, G., Rodriguez-Rojas, R., Rodriguez-Oroz, M. C., Guridi, J., Lozano, Andres M., editor, Gildenberg, Philip L., editor, and Tasker, Ronald R., editor

Published
2009
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8. Therapeutic efficacy of unilateral subthalamotomy in Parkinson's disease: results in 89 patients followed for up to 36 months

Author

Alvarez, L., Macias, R., Pavon, N., Lopez, G., Rodriguez-Oroz, M.C., Rodriguez, R., Alvarez, M., Pedroso, I., Teijeiro, J., Fernandez, R., Casabona, E., Salazar, S., Maragoto, C., Carballo, M., Garcia, I., Guridi, J., Juncos, J.L., DeLong, M.R., and Obeso, J.A.

Subjects
Parkinson's disease -- Care and treatment, Parkinson's disease -- Patient outcomes, Parkinson's disease -- Research, Brain stimulation -- Usage, Brain stimulation -- Patient outcomes, Brain stimulation -- Research, Thalamus -- Physiological aspects, Thalamus -- Research, Health, Psychology and mental health
Published
2009

11. El papel de la tractografía en la localización del núcleo ventralis intermediusdel tálamo y el haz dentatorrubrotalámico en el tratamiento del temblor

Author

Parras, O., Domínguez, P., Tomás-Biosca, A., and Guridi, J.

Abstract

La diana habitual empleada para el tratamiento quirúrgico del temblor es el núcleo ventralis intermedius(Vim) del tálamo. Su localización es compleja, ya que no se puede visualizar con métodos de imagen convencionales, por lo que para el procedimiento quirúrgico se toman clásicamente medidas indirectas y se correlacionan con la clínica y neurofisiología intraoperatorias. Sin embargo, procedimientos ablativos actuales como la talamotomía por gamma-knifeo por ultrasonidos (MRgFUS) hacen que sea preciso buscar otras alternativas para su localización. El objetivo del presente trabajo es comparar la localización indirecta del Vim mediante técnica esterotáctica con la realizada directamente por tractografía para el tratamiento del temblor.

Published
2022
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17. Bilateral deep brain stimulation in Parkinsonʼs disease: a multicentre study with 4 years follow-up

Author

Rodriguez-Oroz, M. C., Obeso, J. A., Lang, A. E., Houeto, J.-L., Pollak, P., Rehncrona, S., Kulisevsky, J., Albanese, A., Volkmann, J., Hariz, M. I., Quinn, N. P., Speelman, J. D., Guridi, J., Zamarbide, I., Gironell, A., Molet, J., Pascual-Sedano, B., Pidoux, B., Bonnet, A. M., Agid, Y., Xie, J., Benabid, A.-L., Lozano, A. M., Saint-Cyr, J., Romito, L., Contarino, M. F., Scerrati, M., Fraix, V., and Van Blercom, N.

Published
2005

24. Thalamic Deep Brain Stimulation for Orthostatic Tremor: A Multicenter International Registry

Author

Merola, A., Fasano, A., Hassan, A., Ostrem, J.L., Contarino, M.F., Lyons, M., Krauss, J.K., Wolf, M.E., Klassen, B.T., Rootselaar, A.F. van, Regidor, I., Duker, A.P., Ondo, W., Guridi, J., Volkmann, J., Shukla, A.W., Mandybur, G.T., Okun, M.S., Witt, K., Starr, P.A., Deuschl, G., Espay, A.J., ANS - Neurodegeneration, and Neurology

Subjects
Adult, Male, Ventral Thalamic Nuclei, treatment, Deep Brain Stimulation, International Cooperation, DBS, orthostatic tremor, Middle Aged, Dizziness, Vim, Tremor, shaky legs, Humans, Female, Registries, Aged, Follow-Up Studies, Retrospective Studies
Abstract

Background: We report the accumulated experience with ventral intermediate nucleus deep brain stimulation for medically refractory orthostatic tremor. Methods: Data from 17 patients were reviewed, comparing presurgical, short-term (0-48 months), and long-term (>= 48 months) follow-up. The primary end point was the composite activities of daily living/instrumental activities of daily living score. Secondary end points included latency of symptoms on standing and treatment-related complications. Results: There was a 21.6% improvement (P = 0.004) in the composite activities of daily living/instrumental activities of daily living score, which gradually attenuated (12.5%) in the subgroup of patients with an additional long-term follow-up (8 of 17). The latency of symptoms on standing significantly improved, both in the shortterm (P = 0.001) and in the long-term (P = 0.018). Three patients obtained no/minimal benefit from the procedure. Conclusions: Deep brain stimulation of the ventral intermediate nucleus was, in general, safe and well tolerated, yielding sustained benefit in selected patients with medically refractory orthostatic tremor. (C) 2017 International

Published
2017

25. P01.096 Hypofractionated radiotherapy and temozolomide in patients with glioblastoma and poor prognostic factors other than age - is it worth it?

Author

Jablonska, P A, primary, Gimeno, M, additional, García-Consuegra, A, additional, Arbea, L, additional, Moreno, M, additional, Azcona, D, additional, Barbés, B, additional, Ramos, L, additional, Aramendía, J M, additional, Gúrpide, A, additional, Guridi, J, additional, Díez Valle, R, additional, Tomás-Biosca, A, additional, Domínguez, P, additional, Arbizu, J, additional, Idoate, M A, additional, and Aristu, J J, additional

Published
2018
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32. Long-term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson's disease

Author

Moro, E, Lozano, Am, Pollak, P, Agid, Y, Rehncrona, S, Volkmann, J, Kulisevsky, J, Obeso, Ja, Albanese, Alberto, Hariz, Mi, Quinn, Np, Speelman, Jd, Benabid, Al, Fraix, V, Mendes, A, Welter, Ml, Houeto, Jl, Cornu, P, Dormont, D, Tornqvist, Al, Ekberg, R, Schnitzler, A, Timmermann, L, Wojtecki, L, Gironell, A, Rodriguez Oroz, Mc, Guridi, J, Bentivoglio, Anna Rita, Contarino, Maria Fiorella, Romito, Luigi Michele Antonio, Scerrati, M, Janssens, M, Lang, Ae, Albanese, Alberto (ORCID:0000-0002-5864-0006), Bentivoglio, Anna Rita (ORCID:0000-0002-9663-095X), Moro, E, Lozano, Am, Pollak, P, Agid, Y, Rehncrona, S, Volkmann, J, Kulisevsky, J, Obeso, Ja, Albanese, Alberto, Hariz, Mi, Quinn, Np, Speelman, Jd, Benabid, Al, Fraix, V, Mendes, A, Welter, Ml, Houeto, Jl, Cornu, P, Dormont, D, Tornqvist, Al, Ekberg, R, Schnitzler, A, Timmermann, L, Wojtecki, L, Gironell, A, Rodriguez Oroz, Mc, Guridi, J, Bentivoglio, Anna Rita, Contarino, Maria Fiorella, Romito, Luigi Michele Antonio, Scerrati, M, Janssens, M, Lang, Ae, Albanese, Alberto (ORCID:0000-0002-5864-0006), and Bentivoglio, Anna Rita (ORCID:0000-0002-9663-095X)

Abstract

We report the 5 to 6 year follow-up of a multicenter study of bilateral subthalamic nucleus (STN) and globus pallidus internus (GPi) deep brain stimulation (DBS) in advanced Parkinson's disease (PD) patients. Thirty-five STN patients and 16 GPi patients were assessed at 5 to 6 years after DBS surgery. Primary outcome measure was the stimulation effect on the motor Unified Parkinson's Disease Rating Scale (UPDRS) assessed with a prospective cross-over double-blind assessment without medications (stimulation was randomly switched on or off). Secondary outcomes were motor UPDRS changes with unblinded assessments in off- and on-medication states with and without stimulation, activities of daily living (ADL), anti-PD medications, and dyskinesias. In double-blind assessment, both STN and GPi DBS were significantly effective in improving the motor UPDRS scores (STN, P < 0.0001, 45.4%; GPi, P = 0.008, 20.0%) compared with off-stimulation, regardless of the sequence of stimulation. In open assessment, both STN- and GPi-DBS significantly improved the off-medication motor UPDRS when compared with before surgery (STN, P < 0.001, 50.5%; GPi, P = 0.002, 35.6%). Dyskinesias and ADL were significantly improved in both groups. Anti-PD medications were significantly reduced only in the STN group. Adverse events were more frequent in the STN group. These results confirm the long-term efficacy of STN and GPi DBS in advanced PD. Although the surgical targets were not randomized, there was a trend to a better outcome of motor signs in the STN-DBS patients and fewer adverse events in the GPi-DBS group.

Published
2010

33. Long-term effects of pallidal or subthalamic deep brain stimulation on quality of life in Parkinson's disease

Author

Volkmann, J, Albanese, Alberto, Kulisevsky, J, Tornqvist, A, Houeto, J, Pidoux, B, Bonnet, A, Mendes, A, Benabid, A, Fraix, V, Van Blercom, N, Xie, J, Obeso, J, Rodriguez Oroz, Mc, Guridi, J, Schnitzler, A, Timmermann, L, Gironell, Aa, Molet, J, Pascual Sedano, B, Rehncrona, S, Moro, Ea, Lang, Ac, Lozano, Am, Bentivoglio, Anna Rita, Scerrati, Massimo, Contarino, Maria Fiorella, Romito, L, Janssens, M, Agid, Y., Albanese, Alberto (ORCID:0000-0002-5864-0006), Bentivoglio, Anna Rita (ORCID:0000-0002-9663-095X), Volkmann, J, Albanese, Alberto, Kulisevsky, J, Tornqvist, A, Houeto, J, Pidoux, B, Bonnet, A, Mendes, A, Benabid, A, Fraix, V, Van Blercom, N, Xie, J, Obeso, J, Rodriguez Oroz, Mc, Guridi, J, Schnitzler, A, Timmermann, L, Gironell, Aa, Molet, J, Pascual Sedano, B, Rehncrona, S, Moro, Ea, Lang, Ac, Lozano, Am, Bentivoglio, Anna Rita, Scerrati, Massimo, Contarino, Maria Fiorella, Romito, L, Janssens, M, Agid, Y., Albanese, Alberto (ORCID:0000-0002-5864-0006), and Bentivoglio, Anna Rita (ORCID:0000-0002-9663-095X)

Abstract

We assessed the effects of deep brain stimulation of the subthalamic nucleus (STN-DBS) or internal pallidum (GPi-DBS) on health-related quality of life (HrQoL) in patients with advanced Parkinson's disease participating in a previously reported multicenter trial. Sickness Impact Profile (SIP) questionnaires were available for analysis in a subgroup of n = 20/20 patients with GPi-DBS and n = 45/49 patients with STN-DBS at baseline, 6 and 36 months. The SIP provides a physical dimension and a psychosocial dimension sum score and 12 category scores: Alertness/Intellectual Behavior (AIB), Ambulation (A), Body Care and Movement (BCM), Communication (C), Eating (E), Emotional Behavior (EB), Home Management (HM), Mobility (M), Recreation and Pastimes (RP), Sleep and Rest (SR), Social Interaction (SI), and Work (W). Motor functioning was assessed by means of the Unified Parkinson's Disease Rating Scale and diaries. At 6 months significant improvements in off-period motor symptoms and activities of daily living were paralleled by significant reductions in the total, physical, and psychosocial SIP score in both treatment groups. At 3 years, sustained improvements were observed in the physical dimension score, BCM, E, M, RP after STN-DBS and M, SI after GPi-DBS. All other SIP subscores approached baseline values, but were still the same or better (except C) whereas motor functioning remained stable after 36 months. STN-DBS and GPi-DBS led to significant early improvements in HrQoL. Despite sustained motor improvements many of these initial benefits were lost after 3 years. This may reflect either progression of the disease or adaptive changes in the subjective perception of health-related wellbeing over time.

Published
2009

34. Exclusive radiosurgery in metastatic brain lesions

Author

Rodríguez-ruiz, M., primary, Olarte Garcia, A., additional, Arevalo, E., additional, Valtueña, G., additional, Arbea, L., additional, Moreno-jimenez, M., additional, Cambeiro, M., additional, Guridi, J., additional, Arbizu, J., additional, Martínez-monge, R., additional, and Aristu, J., additional

Published
2013
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35. Bilateral deep brain stimulation in Parkinson's disease : a multicentre study with 4 years follow-up.

Author

Rodriguez-Oroz, M C, Obeso, J A, Lang, A E, Houeto, J-L, Pollak, P, Rehncrona, S, Kulisevsky, J, Albanese, A, Volkmann, J, Hariz, M I, Quinn, N P, Speelman, J D, Guridi, J, Zamarbide, I, Gironell, A, Molet, J, Pascual-Sedano, B, Pidoux, B, Bonnet, A M, Agid, Y, Xie, J, Benabid, A-L, Lozano, A M, Saint-Cyr, J, Romito, L, Contarino, M F, Scerrati, M, Fraix, V, Van Blercom, N, Rodriguez-Oroz, M C, Obeso, J A, Lang, A E, Houeto, J-L, Pollak, P, Rehncrona, S, Kulisevsky, J, Albanese, A, Volkmann, J, Hariz, M I, Quinn, N P, Speelman, J D, Guridi, J, Zamarbide, I, Gironell, A, Molet, J, Pascual-Sedano, B, Pidoux, B, Bonnet, A M, Agid, Y, Xie, J, Benabid, A-L, Lozano, A M, Saint-Cyr, J, Romito, L, Contarino, M F, Scerrati, M, Fraix, V, and Van Blercom, N

Published
2005

38. P7.9 Subthalamic activity during a motor inhibition task

Author

Alegre, M., primary, Obeso, I., additional, Lopez-Azcarate, J., additional, Rodriguez-Oroz, M. Cruz, additional, Wilkinson, L., additional, Guridi, J., additional, Valencia, M., additional, Artieda, J., additional, Jahanshahi, M., additional, and Obeso, J.A., additional

Published
2011
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43. Radioterapia estereotáctica

Author

Aristu, J.J., primary, Ciérvide, R., additional, Guridi, J., additional, Moreno, M., additional, Arbea, L., additional, Azcona, J.D., additional, Ramos, L.I., additional, and Zubieta, J.L., additional

Published
2009
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44. High frequency stimulation of the subthalamic nucleus and levodopa induced dyskinesias in Parkinson's disease

Author

OBESO, J, LINAZASORO, G, GURIDI, J, RAMOS, E, RODRIGUEZ-OROZ, M, FIGUEIRAS-MENDEZ, R., MARIN-ZARZA, F., MOLINA, J.A., JIMENEZ-JIMENEZ, F.J., ORTI-PAREJA, M., MAGARINOS, C., LOPEZ-PINO, M.A., MARTINEZ, V., OBESO, J, LINAZASORO, G, GURIDI, J, RAMOS, E, RODRIGUEZ-OROZ, M, FIGUEIRAS-MENDEZ, R., MARIN-ZARZA, F., MOLINA, J.A., JIMENEZ-JIMENEZ, F.J., ORTI-PAREJA, M., MAGARINOS, C., LOPEZ-PINO, M.A., and MARTINEZ, V.

Published
2000

47. Dorsal subthalamotomy for Parkinson's disease

Author

Alvarez, L., primary, Macias, R., additional, Guridi, J., additional, Lopez, G., additional, Alvarez, E., additional, Maragoto, C., additional, Teijeiro, J., additional, Torres, A., additional, Pavon, N., additional, Rodriguez-Oroz, M.C., additional, Ochoa, L., additional, Hetherington, H., additional, Juncos, J., additional, DeLong, M.R., additional, and Obeso, J.A., additional

Published
2001
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