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11 results on '"Gurgel Rocha, Clarissa Araújo"'

1. In silico approaches for drug repurposing in oncology: a scoping review

Author

Cavalcante, Bruno Raphael Ribeiro, primary, Freitas, Raíza Dias, additional, Siquara da Rocha, Leonardo de Oliveira, additional, Santos, Roberto de Souza Batista Dos, additional, Souza, Bruno Solano de Freitas, additional, Ramos, Pablo Ivan Pereira, additional, Rocha, Gisele Vieira, additional, and Gurgel Rocha, Clarissa Araújo, additional

Published
2024
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2. In silico approaches for drug repurposing in oncology: a scoping review.

Author

Ribeiro Cavalcante, Bruno Raphael, Dias Freitas, Raíza, de Oliveira Siquara da Rocha, Leonardo, de Souza Batista Dos Santos, Roberto, de Freitas Souza, Bruno Solano, Pereira Ramos, Pablo Ivan, Vieira Rocha, Gisele, and Gurgel Rocha, Clarissa Araújo

Subjects
DRUG repositioning, ANTINEOPLASTIC agents, DRUG discovery, THERAPEUTICS, MOLECULAR dynamics, NANOMEDICINE
Abstract

Introduction: Cancer refers to a group of diseases characterized by the uncontrolled growth and spread of abnormal cells in the body. Due to its complexity, it has been hard to find an ideal medicine to treat all cancer types, although there is an urgent need for it. However, the cost of developing a new drug is high and time-consuming. In this sense, drug repurposing (DR) can hasten drug discovery by giving existing drugs new disease indications. Many computational methods have been applied to achieve DR, but just a few have succeeded. Therefore, this review aims to show in silico DR approaches and the gap between these strategies and their ultimate application in oncology. Methods: The scoping review was conducted according to the Arksey and O’Malley framework and the Joanna Briggs Institute recommendations. Relevant studies were identified through electronic searching of PubMed/ MEDLINE, Embase, Scopus, and Web of Science databases, as well as the grey literature. We included peer-reviewed research articles involving in silico strategies applied to drug repurposing in oncology, published between 1 January 2003, and 31 December 2021. Results: We identified 238 studies for inclusion in the review. Most studies revealed that the United States, India, China, South Korea, and Italy are top publishers. Regarding cancer types, breast cancer, lymphomas and leukemias, lung, colorectal, and prostate cancer are the top investigated. Additionally, most studies solely used computational methods, and just a few assessed more complex scientific models. Lastly, molecular modeling, which includes molecular docking and molecular dynamics simulations, was the most frequently used method, followed by signature-, Machine Learning-, and network-based strategies. Discussion: DR is a trending opportunity but still demands extensive testing to ensure its safety and efficacy for the new indications. Finally, implementing DR can be challenging due to various factors, including lack of quality data, patient populations, cost, intellectual property issues, market considerations, and regulatory requirements. Despite all the hurdles, DR remains an exciting strategy for identifying new treatments for numerous diseases, including cancer types, and giving patients faster access to new medications. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Hedgehog pathway activation in oral squamous cell carcinoma: cancer-associated fibroblasts exhibit nuclear GLI-1 localization

Author

Guimaraes, Vanessa Sousa Nazare, Vidal, Manuela Torres Andion, de Faro Valverde, Ludmila, de Oliveira, Marbele Guimarães, de Oliveira Siquara da Rocha, Leonardo, Coelho, Paulo Lucas Cerqueira, Soares, Fernando Augusto, de Freitas Souza, Bruno Solano, Bezerra, Daniel Pereira, Coletta, Ricardo D., Pereira, Thiago Almeida, dos Santos, Jean Nunes, and Gurgel Rocha, Clarissa Araújo

Published
2020
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5. SARS-CoV-2 Detection via RT-PCR in Matched Saliva and Nasopharyngeal Samples Reveals High Concordance in Different Commercial Assays

Author

de Sousa, Karoline Almeida Felix, primary, Nonaka, Carolina Kymie Vasques, additional, de Ávila Mendonça, Renata Naves, additional, Mascarenhas, Verena Neiva, additional, Weber, Thamires Gomes Lopes, additional, Regis Silva, Carlos Gustavo, additional, Mendes, Ana Verena Almeida, additional, Khouri, Ricardo, additional, Souza, Bruno Solano Freitas, additional, and Gurgel Rocha, Clarissa Araújo, additional

Published
2023
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7. Inhibition of CAL27 Oral Squamous Carcinoma Cell by Targeting Hedgehog Pathway With Vismodegib or Itraconazole

Author

Freitas, Raíza Dias, primary, Dias, Rosane Borges, additional, Vidal, Manuela Torres Andion, additional, Valverde, Ludmila de Faro, additional, Gomes Alves Costa, Rafaela, additional, Damasceno, Andresa Karen Andrade, additional, Sales, Caroline Brandi Schlaepfer, additional, Siquara da Rocha, Leonardo de Oliveira, additional, dos Reis, Mitermayer Galvão, additional, Soares, Milena Botelho Pereira, additional, Coletta, Ricardo Della, additional, Pereira, Thiago Almeida, additional, Bezerra, Daniel Pereira, additional, and Gurgel Rocha, Clarissa Araújo, additional

Published
2020
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9. Enhanced Expression of Hedgehog Pathway Proteins in Oral Epithelial Dysplasia

Author

Dias, Rosane Borges, primary, Valverde, Ludmila de Faro, additional, Sales, Caroline Brandi Schlaepfer, additional, Guimarães, Vanessa Sousa Nazaré, additional, Cabral, Márcia Grillo, additional, de Aquino Xavier, Flávia Caló, additional, dos Santos, Jean Nunes, additional, Ramos, Eduardo Antônio Gonçalves, additional, and Gurgel Rocha, Clarissa Araújo, additional

Published
2016
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10. Elevated VEGFA mRNA levels in oral squamous cell carcinomas and tumor margins: a preliminary study

Author

Sales, Caroline Brandi Schlaepfer, primary, Buim, Marcilei Eliza Cavichiolli, additional, de Souza, Renata Oliveira, additional, de Faro Valverde, Ludmila, additional, Mathias Machado, Maria Cecília, additional, Reis, Mitermayer Galvão, additional, Soares, Fernando Augusto, additional, Ramos, Eduardo Antônio Gonçalves, additional, and Gurgel Rocha, Clarissa Araújo, additional

Published
2016
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