Search

Your search keyword '"Guravitz L"' showing total 5 results
Start Over Author "Guravitz L"
5 results on '"Guravitz L"'

2. PERSISTENCE OF ANTIBODY (AB) TO HAEMOPHILUS INFLUENZAE TYPE B (HIB) AND RESPONSE TO PRP AND PRP-D BOOS-TER IMMUNIZATION IN CHILDREN INITIALLY IMMUNIZED WITH EITHER VACCINE AT 15 TO 24 MONTHS

Author

Berkowitz, C D, Ward, J I, Hendley, J O, Meier, K, McVerry, P, Gordon, L, Chiu, C, and Guravitz, L

Abstract

Children initially imnunized with PRP or PRP-D conjugate vaccines between 15 and 24 months of age were assessed 1 year later for persistence of AB and response to revaccination with PRP, PRP-D, or normal saline (N=111). Pre and post-vaccination sera were obtained and anti-PRP antibodies were assayed by RIA. Adverse reactions were minor and noted in <5% of vaccinees. AB levels a year after initial immunization were significantly higher in subjects immunized with PRP-D(GM 1.12 ug/ml) than with PRP (0.22 ug/ml)(p<.0001). All groups demonstrated an increase in anti-PRP levels after revaccination, although this response was significantly greater in subjects initially immunized with PRP-D, regardless of booster vaccine given. Initial vaccine:Children immunized with PRP or PRP-D between 15 to 24 months of age respond dramatically to reimmnunization one year later, although children previously immunized with PRP-D show the greatest responses even with conventional PRP antigen.

Published
1987
Full Text
View/download PDF

3. Leukocyte responses to diphtheria-tetanus-pertussis and diphtheria-tetanus immunization.

Author

Blumberg DA, Lewis K, Cherry JD, Christenson PD, Guravitz L, Marcy SM, and Levin SR

Subjects
Blood Glucose metabolism, Child, Preschool, Diphtheria-Tetanus Vaccine, Drug Combinations, Humans, Hydrocortisone blood, Insulin blood, Diphtheria Toxoid adverse effects, Diphtheria-Tetanus-Pertussis Vaccine adverse effects, Leukocytosis etiology, Tetanus Toxoid adverse effects
Published
1991
Full Text
View/download PDF

4. Pathophysiology of reactions associated with pertussis vaccine.

Author

Blumberg DA, Mink CM, Lewis K, Chatfield P, Leach C, Smith LP, Christenson PD, Guravitz L, Steinfeld MB, and Marcy SM

Subjects
Blood Glucose metabolism, Crying, Fever etiology, Humans, Infant, Insulin blood, Leukocytosis etiology, Muscle Hypotonia etiology, Pertussis Toxin, Pertussis Vaccine analysis, Seizures etiology, Virulence Factors, Bordetella blood, Pertussis Vaccine adverse effects
Abstract

Many adverse clinical events occur after pertussis immunization in children, but the pathophysiology is not well understood. It has been suggested that some of these adverse events may be due to biologically-active LPF and endotoxin present in DTP vaccines. Fifty-six children were studied who experienced severe reactions (fever greater than or equal to 40.5 degrees C, seizures, persistent crying greater than or equal to 3 hours or hypotonic-hyporesponsive episodes) within 48 hr of DTP immunization. Leukocytosis with neutrophilia was noted acutely (after vaccination) compared to follow-up (approximately one month later). No changes in insulin or glucose values were noted. Utilizing the CHO cell assay, no biologically-active LPF was found in the acute sera of children who had DTP-associated seizures. We found no evidence that biologically-active LPF or altered insulin/glucose metabolism were related to severe DTP-associated reactions.

Published
1991

5. Factors influencing immunogenicity and safety of two Haemophilus influenzae type b polysaccharide vaccines in children 18 and 24 months of age.

Author

Greenberg DP, Ward JI, Burkart K, Christenson PD, Guravitz L, and Marcy SM

Subjects
Age Factors, Bacterial Capsules, Bacterial Vaccines adverse effects, Child, Preschool, Double-Blind Method, Humans, Infant, Prospective Studies, Random Allocation, Antibodies, Bacterial biosynthesis, Bacterial Vaccines immunology, Haemophilus Vaccines, Haemophilus influenzae immunology, Polysaccharides, Bacterial
Abstract

The purpose of this study was to evaluate differences in the safety and immunogenicity of Haemophilus influenzae type b (Hib) capsular polysaccharide vaccine produced by two manufacturers (Connaught and Praxis) in children 18 and 24 months of age. Eighty-five children were evaluated in a prospective, double-blind, randomized fashion. Postvaccination antibody concentrations (measured by radioimmunoassay) and response rates were not significantly different between the two manufacturers' vaccines but immunogenicity was significantly less in 18-month-old children (antibody concentration, 0.149 microgram/ml) compared with 24-month-old children (0.838 microgram/ml) (P = 0.001). No significant differences were noted in the safety of the two vaccines. This study suggests that previously observed differences of immunogenicity data between various type b capsular polysaccharide vaccines are due to differences in antibody assays, not in vaccines. Eighteen-month-old children appear to have a relatively poor immune response to type b capsular polysaccharide. Therefore to optimize the benefits of immunization, we suggest children receive this vaccine at 24 months of age.

Published
1987
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results