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17. Next generation medical education from the student’s perspective

Author

Yavuz Nurgül, Çula Nazlı Begüm, Ataş Birce, Gür Dilara, Asker Emre, Nakay Kerem, Gültekin Elif Sıdal, Kılıççıoğlu Uğur, Akbulut Yalçın Ural Turhan, and Taşkın Zeynep

Subjects
e-learning, integrated curriculum, lifelong learning, medical education, tıp eğitimi, hayat boyu öğrenme, entegre müfredat, e-öğrenme, Biochemistry, QD415-436
Abstract

Izmir University of Economics Faculty of Medicine’s aim is to implement a novel and effective system called “Next Generation Medical Education”. This system is designed to provide us a modernized medical education which covers the students’ requirements. This study is designed to investigate different aspects of this educational system from the student’s perspective.

Published
2022
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18. Efficacy of nasopharyngeal culture in identification of pathogens in middle ear fluid in chronic otitis media with effusion

Author

Eser, O., Ipci, K., Alp, S., Akyol, U., Unal, O., Hascelik, G., Sennaroglu, L., and Gur, D.

Subjects
Pathogenic microorganisms, Otitis media with effusion, Bacterial pneumonia, Pneumonia, Medical research, Medicine, Experimental, Health
Abstract

Purpose: Chronic otitis media with effusion (OME) is the leading cause of hearing loss during childhood. In bacterial etiology of OME, the most frequent pathogens responsible are Haemophilus influenzae followed [...]

Published
2009

19. Evaluation of a chromogenic medium for rapid detection of extended spectrum beta-lactamase producing Salmonella spp

Author

Kocagoz, S, Budak, F, Gur, D, Kocagoz, S, Budak, F, Gur, D, and Yeditepe Üniversitesi

Subjects
ESBL, Salmonella, Quicolor, biochemical phenomena, metabolism, and nutrition, medium, E&S agar
Abstract

Background & objectives: Salmonella spp. resistant to second- and third-generation cephalosporins and related antibiotics by production of various extended-spectrum beta-lactamases (ESBLs) are on the rise in Turkey. Early detection of ESBL producing Salmonella is important to institute appropriate treatment in time. In this study rapid detection of ESBL production among clinical isolates of Salmonella was evaluated using double-disk synergy test in a new chromogenic medium. The colour of the medium changes from red to yellow with bacterial growth and red circular inhibition zones are produced around disks containing antibacterials. Methods: A total of 182 clinical isolates of Salmonella were evaluated in this study. The presence of ESBLs in clinical isolates was determined by double-disk synergy test using Mueller-Hinton (MH) agar and Quicolor E&S agar plates. Results: Six isolates were shown to harbour ESBL enzymes with double disk synergy test by Mueller Hinton agar. The same results were obtained using Quicolor E&S agar after 4-6 h by changing its colour in response to the metabolic activity of growing bacteria. Interpretation & conclusion: Our findings showed that with this new medium, the results can be evaluated rapidly within 4-6 h and the enhancement of inhibition zones can be easily detected with the colour changes thus enabling the treating physician to institute the right treatment regimen immediately.

Published
2006

20. Poster session 3Cell growth, differentiation and stem cells - Heart511The role of the endocannabinoid system in modelling muscular dystrophy cardiac disease with induced pluripotent stem cells.512An emerging role of T lymphocytes in cardiac regenerative processes in heart failure due to dilated cardiomyopathy513Canonical wnt signaling reverses the ‘aged/senescent’ human endogenous cardiac stem cell phenotype514Hippo signalling modulates survival of human induced pluripotent stem cell-derived cardiomyocytes515Biocompatibility of mesenchymal stem cells with a spider silk matrix and its potential use as scaffold for cardiac tissue regeneration516A snapshot of genome-wide transcription in human induced pluripotent stem cell-derived hepatocyte-like cells (iPSC-HLCs)517Can NOS/sGC/cGK1 pathway trigger the differentiation and maturation of mouse embryonic stem cells (ESCs)?518Introduction of external Ik1 to human-induced pluripotent stem cell-derived cardiomyocytes via Ik1-expressing HEK293519Cell therapy of the heart studied using adult myocardial slices in vitro520Enhancement of the paracrine potential of human adipose derived stem cells when cultured as spheroid bodies521Mechanosensitivity of cardiomyocyte progenitor cells: the strain response in 2D and 3D environments522The effect of the vascular-like network on the maturation of the human induced pluripotent stem cell derived cardiomyocytes.Transcriptional control and RNA species - Heart525Gene expression regulation in heart failure: from pathobiology to bioinformatics526Human transcriptome in idiopathic dilated cardiomyopathy - a novel high throughput screening527A high-throghput approach unveils putative miRNA-mediated mitochondria-targeted cardioprotective circuits activated by T3 in the post ischemia reperfusion setting528The effect of uraemia on the expression of miR-212/132 and the calcineurin pathway in the rat heartCytokines and cellular inflammation - Heart531Lack of growth differentiation factor 15 aggravates adverse cardiac remodeling upon pressure-overload in mice532Blocking heteromerization of platelet chemokines ccl5 and cxcl4 reduces inflammation and preserves heart function after myocardial infarction533Is there an association between low-dose aspirin use and clinical outcome in HFPEF? Implications of modulating monocyte function and inflammatory mediator release534N-terminal truncated intracellular matrix metalloproteinase-2 expression in diabetic heart.535Expression of CD39 and CD73 on peripheral T-cell subsets in calcific aortic stenosis536Mast cells in the atrial myocardium of patients with atrial fibrillation: a comparison with patients in sinus rhythm539Characteristics of the inflammatory response in patients with coronary artery disease and arterial hypertension540Pro-inflammatory cytokines as cardiovascular events predictors in rheumatoid arthritis and asymptomatic atherosclerosis541Characterization of FVB/N murinic bone marrow-derived macrophage polarization into M1 and M2 phenotypes542The biological expression and thoracic anterior pain syndromeSignal transduction - Heart545The association of heat shock protein 90 and TGFbeta receptor I is involved in collagen production during cardiac remodelling in aortic-banded mice546Loss of the inhibitory GalphaO protein in the rostral ventrolateral medulla of the brainstem leads to abnormalities in cardiovascular reflexes and altered ventricular excitablitiy547Selenoprotein P regulates pressure overload-induced cardiac remodeling548Study of adenylyl cyclase activity in erythrocyte membranes in patients with chronic heart failure549Direct thrombin inhibitors inhibit atrial myocardium hypertrophy in a rat model of heart failure and atrial remodeling550Tissue factor / FVIIa transactivates the IGF-1R by a Src-dependent phosphorylation of caveolin-1551Notch signaling is differently altered in endothelial and smooth muscle cells of ascending aortic aneurysm patients552Frizzled 5 expression is essential for endothelial proliferation and migration553Modulation of vascular function and ROS production by novel synthetic benzopyran analogues in diabetes mellitusExtracellular matrix and fibrosis - Heart556Cardiac fibroblasts as inflammatory supporter cells trigger cardiac inflammation in heart failure557A role for galectin-3 in calcific aortic valve stenosis558Omega-3 polyunsaturated fatty acids- can they decrease risk for ventricular fibrillation?559Serum levels of elastin derived peptides and circulating elastin-antielastin immune complexes in sera of patients with coronary artery disease560Endocardial fibroelastosis is secondary to hemodynamic alterations in the chick model of hypoplastic left heart syndrome561Dynamics of serum levels of matrix metalloproteinases in primary anterior STEMI patients564Deletion of the alpha-7 nicotinic acetylcholine receptor changes the vascular remodeling induced by transverse aortic constriction in mice.565Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veinsIon channels, ion exchangers and cellular electrophysiology - Heart568Microtubule-associated protein RP/EB family member 1 modulates sodium channel trafficking and cardiac conduction569Investigation of electrophysiological abnormalities in a rabbit athlete's heart model570Upregulation of expression of multiple genes in the atrioventricular node of streptozotocin-induced diabetic rat571miR-1 as a regulator of sinoatrial rhythm in endurance training adaptation572Selective sodium-calcium exchanger inhibition reduces myocardial dysfunction associated with hypokalaemia and ventricular fibrillation573Effect of racemic and levo-methadone on action potential of human ventricular cardiomyocytes574Acute temperature effects on the chick embryonic heart functionVasculogenesis, angiogenesis and arteriogenesis577Clinical improvement and enhanced collateral vessel growth after monocyte transplantation in mice578The role of HIF-1 alpha, VEGF and obstructive sleep apnoea in the development of coronary collateral circulation579Initiating cardiac repair with a trans-coronary sinus catheter intervention in an ischemia/reperfusion porcine animal model580Early adaptation of pre-existing collaterals after acute arteriolar and venular microocclusion: an in vivo study in chick chorioallantoic membraneEndothelium583EDH-type responses to the activator of potassium KCa2.3 and KCa3.1 channels SKA-31 in the small mesenteric artery from spontaneously hypertensive rats584The peculiarities of endothelial dysfunction in patients with chronic renocardial syndrome585Endothelial dysfunction, atherosclerosis of the carotid arteries and level of leptin in patient with coronary heart disease in combination with hepatic steatosis depend from body mass index.586Role of non-coding RNAs in thoracic aortic aneurysm associated with bicuspid aortic valve587Cigarette smoke extract abrogates atheroprotective effects of high laminar flow on endothelial function588The prognostic value of anti-connective tissue antibodies in coronary heart disease and asymptomatic atherosclerosis589Novel potential properties of bioactive peptides from spanish dry-cured ham on the endothelium.Lipids592Intermediate density lipoprotein is associated with monocyte subset distribution in patients with stable atherosclerosis593The characteristics of dyslipidemia in rheumatoid arthritisAtherosclerosis596Macrophages differentiated in vitro are heterogeneous: morphological and functional profile in patients with coronary artery disease597Palmitoylethanolamide promotes anti-inflammatory phenotype of macrophages and attenuates plaque formation in ApoE-/- mice598Amiodarone versus esmolol in the perioperative period: an in vitro study of coronary artery bypass grafts599BMPRII signaling of fibrocytes, a mesenchymal progenitor cell population, is increased in STEMI and dyslipidemia600The characteristics of atherogenesis and systemic inflammation in rheumatoid arthritis601Role of adenosine-to-inosine RNA editing in human atherosclerosis602Presence of bacterial DNA in thrombus aspirates of patients with myocardial infarction603Novel E-selectin binding polymers reduce atherosclerotic lesions in ApoE(-/-) mice604Differential expression of the plasminogen receptor Plg-RKT in monocyte and macrophage subsets - possible functional consequences in atherogenesis605Apelin-13 treatment enhances the stability of atherosclerotic plaques606Mast cells are increased in the media of coronary lesions in patients with myocardial infarction and favor atherosclerotic plaque instability607Association of neutrophil to lymphocyte ratio with presence of isolated coronary artery ectasiaCalcium fluxes and excitation-contraction coupling610The coxsackie- and adenovirus receptor (CAR) regulates calcium homeostasis in the developing heart611HMW-AGEs application acutely reduces ICaL in adult cardiomyocytes612Measuring electrical conductibility of cardiac T-tubular systems613Postnatal development of cardiac excitation-contraction coupling in rats614Role of altered Ca2+ homeostasis during adverse cardiac remodeling after ischemia/reperfusion615Experimental study of sarcoplasmic reticulum dysfunction and energetic metabolism in failing myocardium associated with diabetes mellitusHibernation, stunning and preconditioning618Volatile anesthetic preconditioning attenuates ischemic-reperfusion injury in type II diabetic patients undergoing on-pump heart surgery619The effect of early and delayed phase of remote ischemic preconditioning on ischemia-reperfusion injury in the isolated hearts of healthy and diabetic rats620Post-conditioning with 1668-thioate leads to attenuation of the inflammatory response and remodeling with less fibrosis and better left ventricular function in a murine model of myocardial infarction621Maturation-related changes in response to ischemia-reperfusion injury and in effects of classical ischemic preconditioning and remote preconditioningMitochondria and energetics624Phase changes in myocardial mitochondrial respiration caused by hypoxic preconditioning or periodic hypoxic training625Desmin mutations depress mitochondrial metabolism626Methylene blue modulates mitochondrial function and monoamine oxidases-related ROS production in diabetic rat hearts627Doxorubicin modulates the real-time oxygen consumption rate of freshly isolated adult rat and human ventricular cardiomyocytesCardiomyopathies and fibrosis630Effects of genetic or pharmacologic inhibition of the ubiquitin/proteasome system on myocardial proteostasis and cardiac function631Suppression of Wnt signalling in a desmoglein-2 transgenic mouse model for arrhythmogenic cardiomyopathy632Cold-induced cardiac hypertrophy is reversed after thermo-neutral deacclimatization633CD45 is a sensitive marker to diagnose lymphocytic myocarditis in endomyocardial biopsies of living patients and in autopsies634Atrial epicardial adipose tissue derives from epicardial progenitors635Caloric restriction ameliorates cardiac function, sympathetic cardiac innervation and beta-adrenergic receptor signaling in an experimental model of post-ischemic heart failure636High fat diet improves cardiac remodelling and function after extensive myocardial infarction in mice637Epigenetic therapy reduces cardiac hypertrophy in murine models of heart failure638Imbalance of the VHL/HIF signaling in WT1+ Epicardial Progenitors results in coronary vascular defects, fibrosis and cardiac hypertrophy639Diastolic dysfunction is the first stage of the developing heart failure640Colchicine aggravates coxsackievirus B3 infection in miceArterial and pulmonary hypertension642Osteopontin as a marker of pulmonary hypertension in patients with coronary heart disease combined with chronic obstructive pulmonary disease643Myocardial dynamic stiffness is increased in experimental pulmonary hypertension partly due to incomplete relaxation644Hypotensive effect of quercetin is possibly mediated by down-regulation of immunotroteasome subunits in aorta of spontaneously hypertensive rats645Urocortin-2 improves right ventricular function and attenuates experimental pulmonary arterial hypertension646A preclinical evaluation of the anti-hypertensive properties of an aqueous extract of Agathosma (Buchu)Biomarkers648The adiponectin level in hypertensive females with rheumatoid arthritis and its relationship with subclinical atherosclerosis649Markers for identification of renal dysfunction in the patients with chronic heart failure650cardio-hepatic syndromes in chronic heart failure: North Africa profile651To study other biomarkers that assess during myocardial infarction652Interconnections of apelin levels with parameters of lipid metabolism in hypertension patients653Plasma proteomics in hypertension: prediction and follow-up of albuminuria during chronic renin-angiotensin system suppression654Soluble RAGE levels in plasma of patients with cerebrovascular events

Author

Gowran, A, primary, Kulikova, T, primary, Lewis, FC, primary, Foldes, G, primary, Fuentes, L, primary, Viiri, LE, primary, Spinelli, V, primary, Costa, A, primary, Perbellini, F, primary, Sid-Otmane, C, primary, Bax, NAM, primary, Pekkanen-Mattila, M, primary, Schiano, C, primary, Chaloupka, A, primary, Forini, F, primary, Sarkozy, M, primary, De Jager, SCA, primary, Vajen, T, primary, Glezeva, N, primary, Lee, H W, primary, Golovkin, A, primary, Kucera, T, primary, Musikhina, NA, primary, Korzhenkov, NP, primary, Santuchi, M DE C, primary, Munteanu, D, primary, Garcia, RG, primary, Ang, R, primary, Usui, S, primary, Kamilova, U, primary, Jumeau, C, primary, Aberg, M, primary, Kostina, DA, primary, Brandt, MM, primary, Muntean, D, primary, Lindner, D, primary, Sadaba, R, primary, Bacova, B, primary, Nikolov, A, primary, Sedmera, D, primary, Ryabov, V, primary, Neto, FP, primary, Lynch, M, primary, Portero, V, primary, Kui, P, primary, Howarth, FC, primary, Gualdoni, A, primary, Prorok, J, primary, Diolaiuti, L, primary, Vostarek, F, primary, Wagner, M, primary, Abela, MA, primary, Nebert, C, primary, Xiang, W, primary, Kloza, M, primary, Maslenko, A, primary, Grechanyk, M, primary, Bhattachariya, A, primary, Morawietz, H, primary, Babaeva, AR, primary, Martinez Sanchez, SM, primary, Krychtiuk, KA, primary, Starodubova, J, primary, Fiorelli, S, primary, Rinne, P, primary, Ozkaramanli Gur, D, primary, Hofbauer, T, primary, Stellos, K, primary, Pinon, P, primary, Tsoref, O, primary, Thaler, B, primary, Fraga-Silva, RA, primary, Fuijkschot, WW, primary, Shaaban, MNS, primary, Matthaeus, C, primary, Deluyker, D, primary, Scardigli, M, primary, Zahradnikova, A, primary, Dominguez, A, primary, Kondrat'eva, D, primary, Sosorburam, T, primary, Murarikova, M, primary, Duerr, GD, primary, Griecsova, L, primary, Portnichenko, VI, primary, Smolina, N, primary, Duicu, OANA M, primary, Elder, JM, primary, Zaglia, T, primary, Lorenzon, A, primary, Ruperez, C, primary, Woudstra, L, primary, Suffee, N, primary, De Lucia, C, primary, Russell-Hallinan, A, primary, Menendez-Montes, I, primary, Kapelko, VI, primary, Emmens, RW, primary, Hetman, O, primary, Van Der Laarse, WJ, primary, Goncharov, S, primary, Adao, R, primary, Huisamen, B, primary, Sirenko, O, primary, Nassiri, I, primary, Tserendavaa, SUMIYA, primary, Yushko, K, primary, Baldan Martin, M, primary, Falcone, C, primary, Vigorelli, V, additional, Nigro, P, additional, Pompilio, G, additional, Stepanova, O, additional, Valikhov, M, additional, Samko, A, additional, Masenko, V, additional, Tereschenko, S, additional, Teoh, T, additional, Domenjo-Vila, E, additional, Theologou, T, additional, Field, M, additional, Awad, W, additional, Yasin, M, additional, Nadal-Ginard, B, additional, Ellison-Hughes, GM, additional, Hellen, N, additional, Vittay, O, additional, Harding, SE, additional, Gomez-Cid, L, additional, Fernandez-Santos, ME, additional, Suarez-Sancho, S, additional, Plasencia, V, additional, Climent, A, additional, Sanz-Ruiz, R, additional, Hedhammar, M, additional, Atienza, F, additional, Fernandez-Aviles, F, additional, Kiamehr, M, additional, Oittinen, M, additional, Viiri, KM, additional, Kaikkonen, M, additional, Aalto-Setala, K, additional, Diolaiuti, L, additional, Laurino, A, additional, Sartiani, L, additional, Vona, A, additional, Zanardelli, M, additional, Cerbai, E, additional, Failli, P, additional, Hortigon-Vinagre, MP, additional, Van Der Heyden, M, additional, Burton, FL, additional, Smith, GL, additional, Watson, S, additional, Scigliano, M, additional, Tkach, S, additional, Alayoubi, S, additional, Terracciano, CM, additional, Ly, HQ, additional, Mauretti, A, additional, Van Marion, MH, additional, Van Turnhout, MC, additional, Van Der Schaft, DWJ, additional, Sahlgren, CM, additional, Goumans, MJ, additional, Bouten, CVC, additional, Vuorenpaa, H, additional, Penttinen, K, additional, Sarkanen, R, additional, Ylikomi, T, additional, Heinonen, T, additional, Grimaldi, V, additional, Aprile, M, additional, Esposito, R, additional, Maiello, C, additional, Soricelli, A, additional, Colantuoni, V, additional, Costa, V, additional, Ciccodicola, A, additional, Napoli, C, additional, Rowe, GC, additional, Johnson, K, additional, Arany, ZP, additional, Del Monte, F, additional, D'aurizio, R, additional, Kusmic, C, additional, Nicolini, G, additional, Baumgart, M, additional, Groth, M, additional, Ucciferri, N, additional, Iervasi, G, additional, Pitto, L, additional, Pipicz, M, additional, Gaspar, R, additional, Siska, A, additional, Foldesi, I, additional, Kiss, K, additional, Bencsik, P, additional, Thum, T, additional, Batkai, S, additional, Csont, T, additional, Haan, JJ, additional, Bosch, L, additional, Brans, MAD, additional, Van De Weg, SM, additional, Deddens, JC, additional, Lee, SJ, additional, Sluijter, JPG, additional, Pasterkamp, G, additional, Werner, I, additional, Projahn, D, additional, Staudt, M, additional, Curaj, A, additional, Soenmez, TT, additional, Simsekyilmaz, S, additional, Hackeng, TM, additional, Von Hundelshausen, P, additional, Koenen, RR, additional, Weber, C, additional, Liehn, EA, additional, Santos-Martinez, M, additional, Medina, C, additional, Watson, C, additional, Mcdonald, K, additional, Gilmer, J, additional, Ledwidge, M, additional, Song, SH, additional, Lee, MY, additional, Park, MH, additional, Choi, JC, additional, Ahn, JH, additional, Park, JS, additional, Oh, JH, additional, Choi, JH, additional, Lee, HC, additional, Cha, KS, additional, Hong, TJ, additional, Kudryavtsev, I, additional, Serebryakova, M, additional, Malashicheva, A, additional, Shishkova, A, additional, Zhiduleva, E, additional, Moiseeva, O, additional, Durisova, M, additional, Blaha, M, additional, Melenovsky, V, additional, Pirk, J, additional, Kautzner, J, additional, Petelina, TI, additional, Gapon, LI, additional, Gorbatenko, EA, additional, Potolinskaya, YV, additional, Arkhipova, EV, additional, Solodenkova, KS, additional, Osadchuk, MA, additional, Dutra, MF, additional, Oliveira, FCB, additional, Silva, MM, additional, Passos-Silva, DG, additional, Goncalves, R, additional, Santos, RAS, additional, Da Silva, RF, additional, Gavrilescu, CM, additional, Paraschiv, CM, additional, Manea, P, additional, Strat, LC, additional, Gomez, JMG, additional, Merino, D, additional, Hurle, MA, additional, Nistal, JF, additional, Aires, A, additional, Cortajarena, AL, additional, Villar, AV, additional, Abramowitz, J, additional, Birnbaumer, L, additional, Gourine, AV, additional, Tinker, A, additional, Takamura, M, additional, Takashima, S, additional, Inoue, O, additional, Misu, H, additional, Takamura, T, additional, Kaneko, S, additional, Alieva, TOHIRA, additional, Mougenot, N, additional, Dufilho, M, additional, Hatem, S, additional, Siegbahn, A, additional, Kostina, AS, additional, Uspensky, VE, additional, Moiseeva, OM, additional, Kostareva, AA, additional, Malashicheva, AB, additional, Van Dijk, CGM, additional, Chrifi, I, additional, Verhaar, MC, additional, Duncker, DJ, additional, Cheng, C, additional, Sturza, A, additional, Petrus, A, additional, Duicu, O, additional, Kiss, L, additional, Danila, M, additional, Baczko, I, additional, Jost, N, additional, Gotzhein, F, additional, Schon, J, additional, Schwarzl, M, additional, Hinrichs, S, additional, Blankenberg, S, additional, Volker, U, additional, Hammer, E, additional, Westermann, D, additional, Martinez-Martinez, E, additional, Arrieta, V, additional, Fernandez-Celis, A, additional, Jimenez-Alfaro, L, additional, Melero, A, additional, Alvarez-Asiain, V, additional, Cachofeiro, V, additional, Lopez-Andres, N, additional, Tribulova, N, additional, Wallukat, G, additional, Knezl, V, additional, Radosinska, J, additional, Barancik, M, additional, Tsinlikov, I, additional, Tsinlikova, I, additional, Nicoloff, G, additional, Blazhev, A, additional, Pesevski, Z, additional, Kvasilova, A, additional, Stopkova, T, additional, Eckhardt, A, additional, Buffinton, C M, additional, Nanka, O, additional, Kercheva, M, additional, Suslova, T, additional, Gusakova, A, additional, Ryabova, T, additional, Markov, V, additional, Karpov, R, additional, Seemann, H, additional, Alcantara, TC, additional, Santuchi, M DE C, additional, Fonseca, SG, additional, Barallobre-Barreiro, J, additional, Oklu, R, additional, Fava, M, additional, Baig, F, additional, Yin, X, additional, Albadawi, H, additional, Jahangiri, M, additional, Stoughton, J, additional, Mayr, M, additional, Podliesna, SP, additional, Veerman, CCV, additional, Verkerk, AOV, additional, Klerk, MK, additional, Lodder, EML, additional, Mengarelli, IM, additional, Bezzina, CRB, additional, Remme, CAR, additional, Takacs, H, additional, Polyak, A, additional, Morvay, N, additional, Lepran, I, additional, Tiszlavicz, L, additional, Nagy, N, additional, Ordog, B, additional, Farkas, A, additional, Forster, T, additional, Varro, A, additional, Farkas, AS, additional, Jayaprakash, P, additional, Parekh, K, additional, Ferdous, Z, additional, Oz, M, additional, Dobrzynski, H, additional, Adrian, TE, additional, Landi, S, additional, Bonzanni, M, additional, D'souza, A, additional, Boyett, M, additional, Bucchi, A, additional, Baruscotti, M, additional, Difrancesco, D, additional, Barbuti, A, additional, Kui, P, additional, Oravecz, K, additional, Hezso, T, additional, Levijoki, J, additional, Pollesello, P, additional, Koskelainen, T, additional, Otsomaa, L, additional, Farkas, A S, additional, Papp, JGY, additional, Toth, A, additional, Acsai, K, additional, Dini, L, additional, Mazzoni, L, additional, Mugelli, A, additional, Svatunkova, J, additional, Sedmera, D, additional, Deffge, C, additional, Baer, C, additional, Weinert, S, additional, Braun-Dullaeus, RC, additional, Herold, J, additional, Cassar, AC, additional, Zahra, GZ, additional, Pllaha, EP, additional, Dingli, PD, additional, Montefort, SM, additional, Xuereb, RGX, additional, Aschacher, T, additional, Messner, B, additional, Eichmair, E, additional, Mohl, W, additional, Reglin, B, additional, Rong, W, additional, Nitzsche, B, additional, Maibier, M, additional, Guimaraes, P, additional, Ruggeri, A, additional, Secomb, TW, additional, Pries, AR, additional, Baranowska-Kuczko, M, additional, Karpinska, O, additional, Kusaczuk, M, additional, Malinowska, B, additional, Kozlowska, H, additional, Demikhova, N, additional, Vynnychenko, L, additional, Prykhodko, O, additional, Grechanyk, N, additional, Kuryata, A, additional, Cottrill, KA, additional, Du, L, additional, Bjorck, HM, additional, Maleki, S, additional, Franco-Cereceda, A, additional, Chan, SY, additional, Eriksson, P, additional, Giebe, S, additional, Cockcroft, N, additional, Hewitt, K, additional, Brux, M, additional, Brunssen, C, additional, Tarasov, AA, additional, Davidov, SI, additional, Reznikova, EA, additional, Tapia Abellan, A, additional, Angosto Bazarra, D, additional, Pelegrin Vivancos, P, additional, Montoro Garcia, S, additional, Kastl, SP, additional, Pongratz, T, additional, Goliasch, G, additional, Gaspar, L, additional, Maurer, G, additional, Huber, K, additional, Dostal, E, additional, Pfaffenberger, S, additional, Oravec, S, additional, Wojta, J, additional, Speidl, WS, additional, Osipova, I, additional, Sopotova, I, additional, Eligini, S, additional, Cosentino, N, additional, Marenzi, G, additional, Tremoli, E, additional, Rami, M, additional, Ring, L, additional, Steffens, S, additional, Gur, O, additional, Gurkan, S, additional, Mangold, A, additional, Scherz, T, additional, Panzenboeck, A, additional, Staier, N, additional, Heidari, H, additional, Mueller, J, additional, Lang, IM, additional, Gatsiou, A, additional, Stamatelopoulos, K, additional, Perisic, L, additional, John, D, additional, Lunella, FF, additional, Hedin, U, additional, Zeiher, A, additional, Dimmeler, S, additional, Nunez, L, additional, Moure, R, additional, Marron-Linares, G, additional, Flores, X, additional, Aldama, G, additional, Salgado, J, additional, Calvino, R, additional, Tomas, M, additional, Bou, G, additional, Vazquez, N, additional, Hermida-Prieto, M, additional, Vazquez-Rodriguez, JM, additional, Amit, U, additional, Landa, N, additional, Kain, D, additional, Tyomkin, D, additional, David, A, additional, Leor, J, additional, Hohensinner, PJ, additional, Baumgartner, J, additional, Krychtiuk, KA, additional, Baik, N, additional, Miles, LA, additional, Seeman, H, additional, Montecucco, F, additional, Da Silva, AR, additional, Costa-Fraga, FP, additional, Anguenot, L, additional, Mach, FP, additional, Stergiopulos, N, additional, Kupreishvili, K, additional, Vonk, ABA, additional, Smulders, YM, additional, Van Hinsbergh, VWM, additional, Stooker, W, additional, Niessen, HWM, additional, Krijnen, PAJ, additional, Ashmawy, MM, additional, Salama, MA, additional, Elamrosy, MZ, additional, Juettner, R, additional, Rathjen, F G, additional, Bito, V, additional, Crocini, C, additional, Ferrantini, C, additional, Gabbrielli, T, additional, Silvestri, L, additional, Coppini, R, additional, Tesi, C, additional, Poggesi, C, additional, Pavone, FS, additional, Sacconi, L, additional, Mackova, K, additional, Zahradnik, I, additional, Zahradnikova, A, additional, Diaz, I, additional, Sanchez De Rojas De Pedro, E, additional, Hmadcha, K, additional, Calderon Sanchez, E, additional, Benitah, JP, additional, Gomez, AM, additional, Smani, T, additional, Ordonez, A, additional, Afanasiev, SA, additional, Egorova, MV, additional, Popov, SV, additional, Wu Qing, P, additional, Cheng, X, additional, Carnicka, S, additional, Pancza, D, additional, Jasova, M, additional, Kancirova, I, additional, Ferko, M, additional, Ravingerova, T, additional, Wu, S, additional, Schneider, M, additional, Marggraf, V, additional, Verfuerth, L, additional, Frede, S, additional, Boehm, O, additional, Dewald, O, additional, Baumgarten, G, additional, Kim, S-C, additional, Farkasova, V, additional, Gablovsky, I, additional, Bernatova, I, additional, Nosar, V, additional, Portnychenko, A, additional, Drevytska, T, additional, Mankovska, I, additional, Gogvadze, V, additional, Sejersen, T, additional, Kostareva, A, additional, Wolf, A, additional, Privistirescu, A, additional, Muntean, D, additional, O ' Gara, P, additional, Sanchez-Alonso, JL, additional, Lyon, AR, additional, Prando, V, additional, Pianca, N, additional, Lo Verso, F, additional, Milan, G, additional, Pesce, P, additional, Sandri, M, additional, Mongillo, M, additional, Beffagna, G, additional, Poloni, G, additional, Dazzo, E, additional, Sabatelli, P, additional, Doliana, R, additional, Polishchuk, R, additional, Carnevale, D, additional, Lembo, G, additional, Bonaldo, P, additional, Braghetta, P, additional, Rampazzo, A, additional, Cairo, M, additional, Giralt, M, additional, Villarroya, F, additional, Planavila, A, additional, Biesbroek, PS, additional, Emmens, RWE, additional, Juffermans, LJM, additional, Van Der Wall, AC, additional, Van Rossum, AC, additional, Niessen, JWM, additional, Moor Morris, T, additional, Dilanian, G, additional, Farahmand, P, additional, Puceat, M, additional, Gambino, G, additional, Petraglia, L, additional, Elia, A, additional, Komici, K, additional, Femminella, GD, additional, D'amico, ML, additional, Pagano, G, additional, Cannavo, A, additional, Liccardo, D, additional, Koch, WJ, additional, Nolano, M, additional, Leosco, D, additional, Ferrara, N, additional, Rengo, G, additional, Neary, R, additional, Shiels, L, additional, Baugh, J, additional, Palacios, B, additional, Escobar, B, additional, Alonso, AV, additional, Guzman, G, additional, Ruiz-Cabello, J, additional, Jimenez-Borreguero, LJ, additional, Martin-Puig, S, additional, Lakomkin, VL, additional, Lukoshkova, EV, additional, Abramov, AA, additional, Gramovich, VV, additional, Vyborov, ON, additional, Ermishkin, VV, additional, Undrovinas, NA, additional, Shirinsky, VP, additional, Smilde, BJ, additional, Woudstra, L, additional, Fong Hing, G, additional, Wouters, D, additional, Zeerleder, S, additional, Murk, JL, additional, Van Ham, SM, additional, Heymans, S, additional, Krakhmalova, O, additional, Van Groen, D, additional, Bogaards, SJP, additional, Schalij, I, additional, Portnichenko, GV, additional, Tumanovska, LV, additional, Goshovska, YV, additional, Lapikova-Bryhinska, TU, additional, Nagibin, VS, additional, Dosenko, VE, additional, Mendes-Ferreira, P, additional, Maia-Rocha, C, additional, Santos-Ribeiro, D, additional, Potus, F, additional, Breuils-Bonnet, S, additional, Provencher, S, additional, Bonnet, S, additional, Rademaker, M, additional, Leite-Moreira, AF, additional, Bras-Silva, C, additional, Lopes, J, additional, Kuryata, O, additional, Lusynets, T, additional, Alikulov, I, additional, Nourddine, M, additional, Azzouzi, L, additional, Habbal, R, additional, Tserendavaa, SUMIYA, additional, Enkhtaivan, ODKHUU, additional, Shagdar, ZORIGO, additional, Malchinkhuu, MUNKHZ, additional, Malchinkhuu, MUNLHZ, additional, Koval, S, additional, Starchenko, T, additional, Mourino-Alvarez, L, additional, Gonzalez-Calero, L, additional, Sastre-Oliva, T, additional, Lopez, JA, additional, Vazquez, J, additional, Alvarez-Llamas, G, additional, Ruilope, LUIS M, additional, De La Cuesta, F, additional, Barderas, MG, additional, Bozzini, S, additional, D'angelo, A, additional, and Pelissero, G, additional

Published
2016
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23. Hydrogen Analysis by Ultra-High Energy Resolution EELS

Author

Cohen, H., primary, Rez, P., additional, Aoki, T., additional, Crozier, P.A., additional, Dellby, N., additional, Dellby, Z., additional, Gur, D., additional, Lovejoy, T.C., additional, March, K., additional, Sarahan, M.C., additional, Wolf, S.G., additional, and Krivanek, O.L., additional

Published
2015
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24. Impact of emphysema heterogeneity on pulmonary function

Author

Ju, J, Li, R, Gu, S, Leader, JK, Wang, X, Chen, Y, Zheng, B, Wu, S, Gur, D, Sciurba, F, Pu, J, Ju, J, Li, R, Gu, S, Leader, JK, Wang, X, Chen, Y, Zheng, B, Wu, S, Gur, D, Sciurba, F, and Pu, J

Abstract

Results: The majority (128/160) of the subjects with COPD had a heterogeneity greater than zero. After adjusting for age, gender, smoking history, and extent of emphysema, heterogeneity in depicted disease in upper lobe dominant cases was positively associated with pulmonary function measures, such as FEV1 Predicted (p<.001) and FEV1/FVC (p<.001), as well as disease severity (p<0.05). We found a negative association between HI% , RV/TLC (p<0.001), and DLco% (albeit not a statistically significant one, p = 0.06) in this group of patients.

Published
2014

25. Genetic variations and antibiotic resistance patterns of Staphylococcus aureus isolates from human and bovine

Author

Unal, N., Istanbulluoglu, E., Gur, D., Unal, S., Bulun, H., and Kırıkkale Üniversitesi

Subjects
Staphylococcus aureus, pulsed-field gel electrophoresis, bovine, human, minimum inhibitory concentration, antimicrobial susceptibility
Abstract

UNAL, SERHAT/0000-0003-1184-4711 WOS: 000272099400005 The study was performed to estimate the genetic relationship among 96 Staphylococcus aureus isolates obtained from human and bovine origins by pulsed-field gel electrophoresis (PFGE) and to investigate resistance profiles of the isolates to 11 antimicrobial agents by the E-test. Thirteen of the human isolates (26%) were resistant to methicillin (MRSA), although all the bovine isolates were Susceptible. In 96 isolates, 45 distinct PFGE types were identified. The results of PFGE were assigned to 18 lineage groups designated A through S based on estimates of genetic relationship. Cluster analysis showed that bacterial genotypes were associated with a single host species. The genotypes corresponding to strains of human origin were more heterogenous. Seventy six percent of the bovine isolates and 34% of the human isolates were assigned to lineage group S and K respectively. Approximately 70% of MRSA strains were included in lineage group K and the comparison of MSSA and MRSA strains showed that the strains were not closely linked. With the exception of MRSA strains, high degree of correlation wits not observed between antimicrobial resistance patterns and the pulsotypes of the isolates. While resistance to penicilin was 100% in human and 80.4% in bovine isolates, it was 48% and 4.3% for erythromycin in human and bovine isolates, respectively. In addition 84.6% of MRSA strains were also resistant to 8 different antimicrobials. It was concluded that the relationship between human and bovine S. aureus isolates were not detected and the number of pulsotype responsible for cow mastitis was limited. MRSA in S. aureus isolates from bovine origin were not ascertained while the rates of resistance to antimicrobial drugs were lower in bovine isolates than those of human isolates.

Published
2009

26. Candida krusei, a multidrug-resistant opportunistic fungal pathogen: geographic and temporal trends from the ARTEMIS DISK Antifungal Surveillance Program, 2001 to 2005

Author

Pfaller, M.A, Diekema, D.J, Gibbs, D.L, Newell, V.A, Nagy, E, Dobiasova, S, Rinaldi, M, Barton, R, Veselov, A, Finquelievich, J, Tiraboschi, N, Ellis, D, Fameree, D, van den Abeele, A.-M, Senterre, J.-M, Lopez Colombo, A, Rennie, R, Sanche, S, Bijie, H, Xu, Y, Fu, W, Zhong, N.S, Rivas, P, de Bedout, C, Mendez, M, Vega, R, Mallatova, N, Ayabaca, J, Zurita, J, Mallie, M, Candolfi, E, Fegeler, W, Haase, P.D.G, Rodloff, A, Bar, W, Czaika, V, Petrikos, G, Puskás, E, Dóczi, I, Mestyan, G, Nikolova, R, Banerjee, U, Keller, N, Tullio, V, Carlo Schito, G, D'Antonio, D, Martino, P, Peng, N.K, Alpuche, C, Santos, J, Morfin Ortero, R, Zaidi, M, Meis, J.F, Lingaas, E, Dzierzanowska, D, Pawliszyn, W, Luz Martins, M, Albuquerque, L, Rosado, L, Velho, R, Amorim, J, Ilina, V.N, Kretchikova, O.I, Klyasova, G.A, Rozanova, S.M, Multykh, I.G, Klimko, N.N, Agapova, E.D, Dmitrieva, N.V, Al-Rasheed, A.M, Shibl, A, Trupl, J, Helena, H, Hoosen, A, Wadula, J, Janse van Rensburg, M.N, Duse, A, Lee, K, Kim, M.-N, del Palacio, A, Sanchez-Sousa, A, Bille, J, Muhlethaler, K, Chang, S.-C, Wang, J.-H, Gur, D, Korten, V, Paul, J, Brown, D, Kibbler, C, Weightman, N, Gould, I.M, Rennison, C, Barnes, R, Vazquez, J, Larone, D, Reyes, H, Santiago, A., and İç Hastalıkları

Subjects
Microbiology (medical), Antifungal Agents, Asia, Microbial Sensitivity Tests, Mycology, Biology, Flucytosine, Microbiology, Middle East, chemistry.chemical_compound, Drug Resistance, Fungal, Amphotericin B, Candida krusei, polycyclic compounds, medicine, Humans, Candida, Voriconazole, Geography, Broth microdilution, Candidiasis, Micafungin, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, biology.organism_classification, Europe, Latin America, chemistry, Hematologic Neoplasms, Africa, North America, Anidulafungin, Caspofungin, medicine.drug
Abstract

Candida krusei is well known as a fungal pathogen for patients with hematologic malignancies and for transplant recipients. Using the ARTEMIS Antifungal Surveillance Program database, we describe geographic and temporal trends in the isolation of C. krusei from clinical specimens and the in vitro susceptibilities of 3,448 isolates to voriconazole as determined by CLSI (formerly NCCLS) disk diffusion testing. In addition, we report the in vitro susceptibilities of bloodstream infection isolates of C. krusei to amphotericin B (304 isolates), flucytosine (254 isolates), anidulafungin (121 isolates), caspofungin (300 isolates), and micafungin (102 isolates) as determined by CLSI broth microdilution methods. Geographic differences in isolation were apparent; the highest frequency of isolation was seen for the Czech Republic (7.6%) and the lowest for Indonesia, South Korea, and Thailand (0 to 0.3%). Overall, 83% of isolates were susceptible to voriconazole, ranging from 74.8% in Latin America to 92.3% in North America. C. krusei was most commonly isolated from hematology-oncology services, where only 76.7% of isolates were susceptible to voriconazole. There was no evidence of increasing resistance of C. krusei to voriconazole from 2001 to 2005. Decreased susceptibilities to amphotericin B (MIC at which 90% of isolates were inhibited [MIC 90 ], 4 μg/ml) and flucytosine (MIC 90 , 16 μg/ml) were noted, whereas 100% of isolates were inhibited by ≤2 μg/ml of anidulafungin (MIC 90 , 0.06 μg/ml), micafungin (MIC 90 , 0.12 μg/ml) or caspofungin (MIC 90 , 0.25 μg/ml). C. krusei is an uncommon but multidrug-resistant fungal pathogen. Among the systemically active antifungal agents, the echinocandins appear to be the most active against this important pathogen.

Published
2008

29. The influence of radiographic phenotype and smoking status on peripheral blood biomarker patterns in chronic obstructive pulmonary disease

Author

Bon, JM, Leader, JK, Weissfeld, JL, Coxson, HO, Zheng, B, Branch, RA, Kondragunta, V, Lee, JS, Zhang, Y, Choi, AMK, Lokshin, AE, Kaminski, N, Gur, D, Sciurba, FC, Bon, JM, Leader, JK, Weissfeld, JL, Coxson, HO, Zheng, B, Branch, RA, Kondragunta, V, Lee, JS, Zhang, Y, Choi, AMK, Lokshin, AE, Kaminski, N, Gur, D, and Sciurba, FC

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is characterized by both airway remodeling and parenchymal destruction. The identification of unique biomarker patterns associated with airway dominant versus parenchymal dominant patterns would support the existence of unique phenotypes representing independent biologic processes. A cross-sectional study was performed to examine the association of serum biomarkers with radiographic airway and parenchymal phenotypes of COPD. Methodology/Principal Findings: Serum from 234 subjects enrolled in a CT screening cohort was analyzed for 33 cytokines and growth factors using a multiplex protein array. The association of serum markers with forced expiratory volume in one second percent predicted (FEV1%) and quantitative CT measurements of airway thickening and emphysema was assessed with and without stratification for current smoking status. Significant associations were found with several serum inflammatory proteins and measurements of FEV1%, airway thickening, and parenchymal emphysema independent of smoking status. The association of select analytes with airway thickening and emphysema was independent of FEV1%. Furthermore, the relationship between other inflammatory markers and measurements of physiologic obstruction or airway thickening was dependent on current smoking status. Conclusions/Significance: Airway and parenchymal phenotypes of COPD are associated with unique systemic serum biomarker profiles. Serum biomarker patterns may provide a more precise classification of the COPD syndrome, provide insights into disease pathogenesis and identify targets for novel patient-specific biological therapies. © 2009 Bon et al.

Published
2009

32. Twelve years of fluconazole in clinical practice : Global-trends in species distribution and fluconazole susceptibility of bloodstream isolates of Candida

Author

Pfaller, M.A., Diekema, D.J., Steele-Moore, L., Denys, G., Staley, C., Dipersio, J.R., Saubolle, M., Wilson, M.L., Overturf, G.D., Peterson, L.R., Schreckenberger, P.C., Doern, G.V., Cavalieri, S., Kehl, S., Brecher, S., Lee, L., Isenberg, H., Hardy, D., Koga, D.S., Fusco, J., Hoffmann, M., Swanzy, S., Murray, P.R., Southern, P., Wanger, A., Reisner, B., Snyder, J., Jenkin, S., Hazen, K., Rennie, R., Hoban, D., Davidson, R., Toye, B., Simor, A., Richardson, S., Robson, H., Smayvsky, J., Casellas, J.M., Sampaio, J.L.M., Prado, V., Garcia, P., Robledo, J.A., Osornio, J.S., Zoccoli, C., Reis, A., Guzman, M., Schwab, D.A., Carroll, K., Chapin-Robertson, K., Bourbeau, P., Sharp, S.E., Barth, A.L., Struelens, M.J., Jarlier, V., Nguyen, J., Roussel-Delvallez, M., Legakis, N., Keller, N., Pascual, A., Linares, J., Canton, R., Prapian, F., Bille, J., Gur, D., Korten, V., Mulazimoglu, L., Unal, S., Kocagoz, S., Debbia, E., French, G., Etienne, J., Raponi, G., Rankin, I., Nicoletti, G., Fadda, G., Hanberger, H., Rangel-Fausto, S., Rodloff, A.C., Smyth, E., Christiansen, K., Coombs, G., Kohno, S., Miyazaki, Y., Schmitz, F.J., Fluit, A.C., Costa, D., Appelbaum, P., Bruckner, D., Chaturvedi, V., Hall, G., Kauffman, C., Sobel, I., Suh, B., Van, Horn K., Finquelievich, J., Tiraboschi, I.N., Colombo, A.L., Crewe-Brown, H.H., Roditi, D., Pfaller, M.A., Diekema, D.J., Steele-Moore, L., Denys, G., Staley, C., Dipersio, J.R., Saubolle, M., Wilson, M.L., Overturf, G.D., Peterson, L.R., Schreckenberger, P.C., Doern, G.V., Cavalieri, S., Kehl, S., Brecher, S., Lee, L., Isenberg, H., Hardy, D., Koga, D.S., Fusco, J., Hoffmann, M., Swanzy, S., Murray, P.R., Southern, P., Wanger, A., Reisner, B., Snyder, J., Jenkin, S., Hazen, K., Rennie, R., Hoban, D., Davidson, R., Toye, B., Simor, A., Richardson, S., Robson, H., Smayvsky, J., Casellas, J.M., Sampaio, J.L.M., Prado, V., Garcia, P., Robledo, J.A., Osornio, J.S., Zoccoli, C., Reis, A., Guzman, M., Schwab, D.A., Carroll, K., Chapin-Robertson, K., Bourbeau, P., Sharp, S.E., Barth, A.L., Struelens, M.J., Jarlier, V., Nguyen, J., Roussel-Delvallez, M., Legakis, N., Keller, N., Pascual, A., Linares, J., Canton, R., Prapian, F., Bille, J., Gur, D., Korten, V., Mulazimoglu, L., Unal, S., Kocagoz, S., Debbia, E., French, G., Etienne, J., Raponi, G., Rankin, I., Nicoletti, G., Fadda, G., Hanberger, H., Rangel-Fausto, S., Rodloff, A.C., Smyth, E., Christiansen, K., Coombs, G., Kohno, S., Miyazaki, Y., Schmitz, F.J., Fluit, A.C., Costa, D., Appelbaum, P., Bruckner, D., Chaturvedi, V., Hall, G., Kauffman, C., Sobel, I., Suh, B., Van, Horn K., Finquelievich, J., Tiraboschi, I.N., Colombo, A.L., Crewe-Brown, H.H., and Roditi, D.

Abstract

We determined the species distribution and in-vitro susceptibility of 6082 bloodstream infection (BSI) isolates of Candida spp. collected from 250 medical centres in 32 nations over a 10-year period from 1992 through 2001. The species included 3401 C. albicans, 984 C. glabrata, 796 C. parapsilosis, 585 C. tropicalis, 153 C. krusei, 67 C. lusitaniae, 48 C. guilliermondii, 10 C. famata, 10 C. kefyr, six C. pelliculosa, five C. rugosa, four C. lipolytica, three C. dubliniensis, three C. inconspicua, two C. sake and one isolate each of C. lambica, C. norvegensis and C. zeylanoides. Minimum inhibitory concentration determinations were made using the National Committee for Clinical Laboratory Standards reference broth microdilution method. Variation in the rank order and frequency of the different species of Candida was observed over time and by geographic area. The proportion of BSI due to C. albicans and C. glabrata increased and C. parapsilosis decreased over time in Canada, the USA and Europe. C. glabrata was an infrequent cause of BSI in Latin America and the Asia-Pacific region. Very little variation in fluconazole susceptibility was observed among isolates of C. albicans, C. tropicalis and C. parapsilosis. These species accounted for 78% of all BSI and remained highly susceptible (91-100% susceptible) to fluconazole from 1992 to 2001 irrespective of geographic origin. The prevalence of fluconazole resistance among C. glabrata isolates was variable both over time and among the various countries and regions. Resistance to fluconazole among C. glabrata isolates was greatest in the USA and varied by US census region (range 0-23%). These observations are generally encouraging relative to the sustained usefulness of fluconazole as a systemically active antifungal agent for the treatment of candida BSI. © 2004 Copyright by the European Society of Clinical Microbiology and Infectious Diseases.

Published
2004
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35. Antimicrobial Resistance in Gram-Negative Hospital Isolates: Results of the Turkish HITIT-2 Surveillance Study of 2007

Author

Gur, D., primary, Hascelik, G., additional, Aydin, N., additional, Telli, M., additional, Gültekin, M., additional, Ögünç, D., additional, Arikan, O.A., additional, Uysal, S., additional, Yaman, A., additional, Kibar, F., additional, Gülay, Z., additional, Sumerkan, B., additional, Esel, D., additional, Kayacan, C.B., additional, Aktas, Z., additional, Soyletir, G., additional, Altinkanat, G., additional, Durupinar, B., additional, Darka, O., additional, Akgün, Y., additional, Yayla, B., additional, Gedikoglu, S., additional, Sinirtas, M., additional, Berktas, M., additional, and Yaman, G., additional

Published
2009
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43. Xenon-enhanced CT of the brain: effect of flow activation on derived cerebral blood flow measurements

Author

Good, W F and Gur, D

Subjects
Xenon, Cerebrovascular Circulation, Journal Article, Humans, Tomography, X-Ray Computed
Abstract

The errors associated with derivation of cerebral blood flow values by the xenon-enhanced CT method have been evaluated through computer simulations as a function of flow-activation patterns and different scanning protocols. The results of this study indicate that actual flow activation during inhalation increases the derived flow values in a systematic way. Compared with the errors introduced by CT noise and/or variations in scanning protocols, flow activation introduces relatively small errors in the derived flow value when the washin technique is used.

Published
1991

44. Stable xenon CT cerebral blood flow imaging: rationale for and role in clinical decision making

Author

Johnson, D W, Stringer, W A, Marks, M P, Yonas, H, Good, W F, and Gur, D

Subjects
Cerebrovascular Disorders, Cerebrovascular Circulation, Journal Article, Humans, Xenon Isotopes, Tomography, X-Ray Computed
Abstract

The stable xenon CT method of measuring cerebral blood flow has been investigated in research studies for over 10 years. Recently, it has been gaining clinical acceptance, primarily owing to a combination of several unique advantages it holds over other cerebral blood flow measurement techniques. The accuracy of this technique in quantifying low cerebral blood flow gives it a unique application in cases of brain death and acute stroke and it can be repeated after an interval of 20 min. making it possible to evaluate autoregulation and cerebrovascular reserve. Furthermore, cerebral blood flow information is directly coupled to CT anatomy. Although it is more difficult to administer than a standard CT scan, careful monitoring can ensure patient safety during the examination. In this article we review the physiologic and technical bases for the clinical application of xenon CT-derived quantitative cerebral blood flow information and discuss the advantages and disadvantages of the technique. We also describe its current clinical applications, including its usefulness in the evaluation of acute stroke, occlusive vascular disease, carotid occlusion testing, vasospasm, arteriovenous malformations, and head trauma management.

Published
1991

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