Search

Your search keyword '"Gupta, Ramneek"' showing total 307 results
Start Over Author "Gupta, Ramneek"
307 results on '"Gupta, Ramneek"'

1. Large Language Model-informed ECG Dual Attention Network for Heart Failure Risk Prediction

Author

Chen, Chen, Li, Lei, Beetz, Marcel, Banerjee, Abhirup, Gupta, Ramneek, and Grau, Vicente

Subjects
Quantitative Biology - Quantitative Methods, Computer Science - Artificial Intelligence, Computer Science - Computation and Language, Computer Science - Machine Learning, Electrical Engineering and Systems Science - Signal Processing
Abstract

Heart failure (HF) poses a significant public health challenge, with a rising global mortality rate. Early detection and prevention of HF could significantly reduce its impact. We introduce a novel methodology for predicting HF risk using 12-lead electrocardiograms (ECGs). We present a novel, lightweight dual-attention ECG network designed to capture complex ECG features essential for early HF risk prediction, despite the notable imbalance between low and high-risk groups. This network incorporates a cross-lead attention module and twelve lead-specific temporal attention modules, focusing on cross-lead interactions and each lead's local dynamics. To further alleviate model overfitting, we leverage a large language model (LLM) with a public ECG-Report dataset for pretraining on an ECG-report alignment task. The network is then fine-tuned for HF risk prediction using two specific cohorts from the UK Biobank study, focusing on patients with hypertension (UKB-HYP) and those who have had a myocardial infarction (UKB-MI).The results reveal that LLM-informed pre-training substantially enhances HF risk prediction in these cohorts. The dual-attention design not only improves interpretability but also predictive accuracy, outperforming existing competitive methods with C-index scores of 0.6349 for UKB-HYP and 0.5805 for UKB-MI. This demonstrates our method's potential in advancing HF risk assessment with clinical complex ECG data., Comment: Under journal revision

Published
2024

3. RWOP1 Genetic risk factors associated with the multimorbid development of chronic kidney disease by cardiovascular disease patients

Author

Ennis, Matthew, primary, McClean, Paula, additional, Shukla, Priyank, additional, Sharman, Joanna L, additional, Leal, Luis G, additional, McVey, Zahra, additional, Nielsen, Rikke L, additional, Hu, Sile, additional, Fadista, Joao PS, additional, Das, Vivek, additional, Ramirez, Mar G, additional, Kitchen, Robert, additional, Gupta, Ramneek, additional, and Watterson, Steven, additional

Published
2024
Full Text
View/download PDF

7. Inherited coding variants at the CDKN2A locus influence susceptibility to acute lymphoblastic leukaemia in children.

Author

Xu, Heng, Zhang, Hui, Yang, Wenjian, Yadav, Rachita, Morrison, Alanna C, Qian, Maoxiang, Devidas, Meenakshi, Liu, Yu, Perez-Andreu, Virginia, Zhao, Xujie, Gastier-Foster, Julie M, Lupo, Philip J, Neale, Geoff, Raetz, Elizabeth, Larsen, Eric, Bowman, W Paul, Carroll, William L, Winick, Naomi, Williams, Richard, Hansen, Torben, Holm, Jens-Christian, Mardis, Elaine, Fulton, Robert, Pui, Ching-Hon, Zhang, Jinghui, Mullighan, Charles G, Evans, William E, Hunger, Stephen P, Gupta, Ramneek, Schmiegelow, Kjeld, Loh, Mignon L, Relling, Mary V, and Yang, Jun J

Subjects
Hematopoietic Stem Cells, Animals, Humans, Mice, Genetic Predisposition to Disease, DNA-Binding Proteins, Transcription Factors, Case-Control Studies, Mutagenesis, Site-Directed, Genotype, Germ-Line Mutation, Mutation, Missense, Child, Cyclin-Dependent Kinase Inhibitor p16, Cyclin-Dependent Kinase Inhibitor p15, Ikaros Transcription Factor, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Genetic Variation, Genome-Wide Association Study, HEK293 Cells, Mutagenesis, Site-Directed, Mutation, Missense
Abstract

There is increasing evidence from genome-wide association studies for a strong inherited genetic basis of susceptibility to acute lymphoblastic leukaemia (ALL) in children, yet the effects of protein-coding variants on ALL risk have not been systematically evaluated. Here we show a missense variant in CDKN2A associated with the development of ALL at genome-wide significance (rs3731249, P=9.4 × 10(-23), odds ratio=2.23). Functional studies indicate that this hypomorphic variant results in reduced tumour suppressor function of p16(INK4A), increases the susceptibility to leukaemic transformation of haematopoietic progenitor cells, and is preferentially retained in ALL tumour cells. Resequencing the CDKN2A-CDKN2B locus in 2,407 childhood ALL cases reveals 19 additional putative functional germline variants. These results provide direct functional evidence for the influence of inherited genetic variation on ALL risk, highlighting the important and complex roles of CDKN2A-CDKN2B tumour suppressors in leukaemogenesis.

Published
2015

8. The genome of a Late Pleistocene human from a Clovis burial site in western Montana.

Author

Rasmussen, Morten, Anzick, Sarah, Waters, Michael, Skoglund, Pontus, DeGiorgio, Michael, Stafford, Thomas, Rasmussen, Simon, Moltke, Ida, Albrechtsen, Anders, Doyle, Shane, Poznik, G, Gudmundsdottir, Valborg, Yadav, Rachita, Malaspinas, Anna-Sapfo, White, Samuel, Allentoft, Morten, Tambets, Kristiina, Eriksson, Anders, Heintzman, Peter, Karmin, Monika, Korneliussen, Thorfinn, Meltzer, David, Pierre, Tracey, Stenderup, Jesper, Saag, Lauri, Warmuth, Vera, Lopes, Margarida, Malhi, Ripan, Brunak, Søren, Sicheritz-Ponten, Thomas, Barnes, Ian, Collins, Matthew, Orlando, Ludovic, Balloux, Francois, Manica, Andrea, Gupta, Ramneek, Metspalu, Mait, Bustamante, Carlos, Jakobsson, Mattias, Willerslev, Eske, Nielsen, Rasmus, and Cornejo, Omar

Subjects
Archaeology, Asia, Bone and Bones, Burial, Chromosomes, Human, Y, DNA, Mitochondrial, Emigration and Immigration, Europe, Gene Flow, Genome, Human, Haplotypes, History, Ancient, Humans, Indians, North American, Infant, Male, Models, Genetic, Molecular Sequence Data, Montana, Phylogeny, Population Dynamics, Radiometric Dating
Abstract

Clovis, with its distinctive biface, blade and osseous technologies, is the oldest widespread archaeological complex defined in North America, dating from 11,100 to 10,700 (14)C years before present (bp) (13,000 to 12,600 calendar years bp). Nearly 50 years of archaeological research point to the Clovis complex as having developed south of the North American ice sheets from an ancestral technology. However, both the origins and the genetic legacy of the people who manufactured Clovis tools remain under debate. It is generally believed that these people ultimately derived from Asia and were directly related to contemporary Native Americans. An alternative, Solutrean, hypothesis posits that the Clovis predecessors emigrated from southwestern Europe during the Last Glacial Maximum. Here we report the genome sequence of a male infant (Anzick-1) recovered from the Anzick burial site in western Montana. The human bones date to 10,705 ± 35 (14)C years bp (approximately 12,707-12,556 calendar years bp) and were directly associated with Clovis tools. We sequenced the genome to an average depth of 14.4× and show that the gene flow from the Siberian Upper Palaeolithic Malta population into Native American ancestors is also shared by the Anzick-1 individual and thus happened before 12,600 years bp. We also show that the Anzick-1 individual is more closely related to all indigenous American populations than to any other group. Our data are compatible with the hypothesis that Anzick-1 belonged to a population directly ancestral to many contemporary Native Americans. Finally, we find evidence of a deep divergence in Native American populations that predates the Anzick-1 individual.

Published
2014

9. Data-driven identification of predictive risk biomarkers for subgroups of osteoarthritis using an interpretable machine learning framework: a UK biobank study

Author

Gupta, Ramneek, primary, Nielsen, Rikke Linnemann, additional, Monfeuga, Thomas, additional, Kitchen, Robert, additional, Egerod, Line, additional, Leal, Luis, additional, Schreyer, August, additional, Sun, Carol, additional, Helenius, Marianne, additional, Simonsen, Lotte, additional, Willert, Marianne, additional, Tahrani, Abd, additional, and McVey, Zahra, additional

Published
2023
Full Text
View/download PDF

11. Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium

Author

Koivula, Robert W., Forgie, Ian M., Kurbasic, Azra, Viñuela, Ana, Heggie, Alison, Giordano, Giuseppe N., Hansen, Tue H., Hudson, Michelle, Koopman, Anitra D. M., Rutters, Femke, Siloaho, Maritta, Allin, Kristine H., Brage, Søren, Brorsson, Caroline A., Dawed, Adem Y., De Masi, Federico, Groves, Christopher J., Kokkola, Tarja, Mahajan, Anubha, Perry, Mandy H., Rauh, Simone P., Ridderstråle, Martin, Teare, Harriet J. A., Thomas, E. Louise, Tura, Andrea, Vestergaard, Henrik, White, Tom, Adamski, Jerzy, Bell, Jimmy D., Beulens, Joline W., Brunak, Søren, Dermitzakis, Emmanouil T., Froguel, Philippe, Frost, Gary, Gupta, Ramneek, Hansen, Torben, Hattersley, Andrew, Jablonka, Bernd, Kaye, Jane, Laakso, Markku, McDonald, Timothy J., Pedersen, Oluf, Schwenk, Jochen M., Pavo, Imre, Mari, Andrea, McCarthy, Mark I., Ruetten, Hartmut, Walker, Mark, Pearson, Ewan, Franks, Paul W., and for the IMI DIRECT Consortium

Published
2019
Full Text
View/download PDF

12. NT5C2 germline variants alter thiopurine metabolism and are associated with acquired NT5C2 relapse mutations in childhood acute lymphoblastic leukaemia

Author

Tulstrup, Morten, Grosjean, Marie, Nielsen, Stine Nygaard, Grell, Kathrine, Wolthers, Benjamin Ole, Wegener, Peder Skov, Jonsson, Olafur Gisli, Lund, Bendik, Harila-Saari, Arja, Abrahamsson, Jonas, Vaitkeviciene, Goda, Pruunsild, Kaie, Toft, Nina, Holm, Mette, Hulegårdh, Erik, Liestøl, Sigurd, Griskevicius, Laimonas, Punab, Mari, Wang, Jinhua, Carroll, William L., Zhang, Zeyu, Dalgaard, Marlene D., Gupta, Ramneek, Nersting, Jacob, and Schmiegelow, Kjeld

Published
2018
Full Text
View/download PDF

13. Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study

Author

Gudmundsdottir, Valborg, Pedersen, Helle Krogh, Mazzoni, Gianluca, Allin, Kristine H., Artati, Anna, Beulens, Joline W., Banasik, Karina, Brorsson, Caroline, Cederberg, Henna, Chabanova, Elizaveta, De Masi, Federico, Elders, Petra J., Forgie, Ian, Giordano, Giuseppe N., Grallert, Harald, Gupta, Ramneek, Haid, Mark, Hansen, Torben, Hansen, Tue H., Hattersley, Andrew T., Heggie, Alison, Hong, Mun-Gwan, Jones, Angus G., Koivula, Robert, Kokkola, Tarja, Laakso, Markku, Løngreen, Peter, Mahajan, Anubha, Mari, Andrea, McDonald, Timothy J., McEvoy, Donna, Musholt, Petra B., Pavo, Imre, Prehn, Cornelia, Ruetten, Hartmut, Ridderstråle, Martin, Rutters, Femke, Sharma, Sapna, Slieker, Roderick C., Syed, Ali, Tajes, Juan Fernandez, Thomas, Cecilia Engel, Thomsen, Henrik S., Vangipurapu, Jagadish, Vestergaard, Henrik, Viñuela, Ana, Wesolowska-Andersen, Agata, Walker, Mark, Adamski, Jerzy, Schwenk, Jochen M., McCarthy, Mark I., Pearson, Ewan, Dermitzakis, Emmanouil, Franks, Paul W., Pedersen, Oluf, and Brunak, Søren

Published
2020
Full Text
View/download PDF

14. Data integration for prediction of weight loss in randomized controlled dietary trials

Author

Nielsen, Rikke Linnemann, Helenius, Marianne, Garcia, Sara L., Roager, Henrik M., Aytan-Aktug, Derya, Hansen, Lea Benedicte Skov, Lind, Mads Vendelbo, Vogt, Josef K., Dalgaard, Marlene Danner, Bahl, Martin I., Jensen, Cecilia Bang, Muktupavela, Rasa, Warinner, Christina, Aaskov, Vincent, Gøbel, Rikke, Kristensen, Mette, Frøkiær, Hanne, Sparholt, Morten H., Christensen, Anders F., Vestergaard, Henrik, Hansen, Torben, Kristiansen, Karsten, Brix, Susanne, Petersen, Thomas Nordahl, Lauritzen, Lotte, Licht, Tine Rask, Pedersen, Oluf, and Gupta, Ramneek

Published
2020
Full Text
View/download PDF

18. Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models

Author

Allesøe, Rosa Lundbye, Lundgaard, Agnete Troen, Hernández Medina, Ricardo, Aguayo-Orozco, Alejandro, Johansen, Joachim, Nissen, Jakob Nybo, Brorsson, Caroline, Mazzoni, Gianluca, Niu, Lili, Biel, Jorge Hernansanz, Brasas, Valentas, Webel, Henry, Benros, Michael Eriksen, Pedersen, Anders Gorm, Chmura, Piotr Jaroslaw, Jacobsen, Ulrik Plesner, Mari, Andrea, Koivula, Robert, Mahajan, Anubha, Vinuela, Ana, Tajes, Juan Fernandez, Sharma, Sapna, Haid, Mark, Hong, Mun-Gwan, Musholt, Petra B., de Masi, Federico, Vogt, Josef, Pedersen, Helle Krogh, Gudmundsdottir, Valborg, Jones, Angus, Kennedy, Gwen, Bell, Jimmy, Thomas, E. Louise, Frost, Gary, Thomsen, Henrik, Hansen, Elizaveta, Hansen, Tue Haldor, Vestergaard, Henrik, Muilwijk, Mirthe, Blom, Marieke T., ‘t Hart, Leen M., Pattou, Francois, Raverdy, Violeta, Brage, Soren, Kokkola, Tarja, Heggie, Alison, McEvoy, Donna, Mourby, Miranda, Kaye, Jane, Hattersley, Andrew, McDonald, Timothy, Ridderstråle, Martin, Walker, Mark, Forgie, Ian, Giordano, Giuseppe N., Pavo, Imre, Ruetten, Hartmut, Pedersen, Oluf, Hansen, Torben, Dermitzakis, Emmanouil, Franks, Paul W., Schwenk, Jochen M., Adamski, Jerzy, McCarthy, Mark I., Pearson, Ewan, Banasik, Karina, Rasmussen, Simon, Brunak, S. ren, Froguel, Philippe, Thomas, Cecilia Engel, Haussler, Ragna, Beulens, Joline, Rutters, Femke, Nijpels, Giel, van Oort, Sabine, Groeneveld, Lenka, Elders, Petra, Giorgino, Toni, Rodriquez, Marianne, Nice, Rachel, Perry, Mandy, Bianzano, Susanna, Graefe-Mody, Ulrike, Hennige, Anita, Grempler, Rolf, Baum, Patrick, Stærfeldt, Hans-Henrik, Shah, Nisha, Teare, Harriet, Ehrhardt, Beate, Tillner, Joachim, Dings, Christiane, Lehr, Thorsten, Scherer, Nina, Sihinevich, Iryna, Cabrelli, Louise, Loftus, Heather, Bizzotto, Roberto, Tura, Andrea, Dekkers, Koen, van Leeuwen, Nienke, Groop, Leif, Slieker, Roderick, Ramisch, Anna, Jennison, Christopher, McVittie, Ian, Frau, Francesca, Steckel-Hamann, Birgit, Adragni, Kofi, Thomas, Melissa, Pasdar, Naeimeh Atabaki, Fitipaldi, Hugo, Kurbasic, Azra, Mutie, Pascal, Pomares-Millan, Hugo, Bonnefond, Amelie, Canouil, Mickael, Caiazzo, Robert, Verkindt, Helene, Holl, Reinhard, Kuulasmaa, Teemu, Deshmukh, Harshal, Cederberg, Henna, Laakso, Markku, Vangipurapu, Jagadish, Dale, Matilda, Thorand, Barbara, Nicolay, Claudia, Fritsche, Andreas, Hill, Anita, Hudson, Michelle, Thorne, Claire, Allin, Kristine, Arumugam, Manimozhiyan, Jonsson, Anna, Engelbrechtsen, Line, Forman, Annemette, Dutta, Avirup, Sondertoft, Nadja, Fan, Yong, Gough, Stephen, Robertson, Neil, McRobert, Nicky, Wesolowska-Andersen, Agata, Brown, Andrew, Davtian, David, Dawed, Adem, Donnelly, Louise, Palmer, Colin, White, Margaret, Ferrer, Jorge, Whitcher, Brandon, Artati, Anna, Prehn, Cornelia, Adam, Jonathan, Grallert, Harald, Gupta, Ramneek, Sackett, Peter Wad, Nilsson, Birgitte, Tsirigos, Konstantinos, Eriksen, Rebeca, Jablonka, Bernd, Uhlen, Mathias, Gassenhuber, Johann, Baltauss, Tania, de Preville, Nathalie, Klintenberg, Maria, Abdalla, Moustafa, Lundgaard, Agnete Troen [0000-0001-7447-6560], Hernández Medina, Ricardo [0000-0001-6373-2362], Johansen, Joachim [0000-0001-7052-1870], Niu, Lili [0000-0003-4571-4368], Biel, Jorge Hernansanz [0000-0002-3125-2951], Benros, Michael Eriksen [0000-0003-4939-9465], Pedersen, Anders Gorm [0000-0001-9650-8965], Jacobsen, Ulrik Plesner [0000-0001-9181-6854], Koivula, Robert [0000-0002-1646-4163], Vinuela, Ana [0000-0003-3771-8537], Haid, Mark [0000-0001-6118-1333], Hong, Mun-Gwan [0000-0001-8603-8293], Kennedy, Gwen [0000-0002-9856-3236], Thomas, E Louise [0000-0003-4235-4694], Frost, Gary [0000-0003-0529-6325], Hansen, Tue Haldor [0000-0001-5948-8993], Kaye, Jane [0000-0002-7311-4725], Hattersley, Andrew [0000-0001-5620-473X], Ridderstråle, Martin [0000-0002-3270-9167], Pedersen, Oluf [0000-0002-3321-3972], Hansen, Torben [0000-0001-8748-3831], Schwenk, Jochen M [0000-0001-8141-8449], Rasmussen, Simon [0000-0001-6323-9041], Brunak, Søren [0000-0003-0316-5866], Apollo - University of Cambridge Repository, Epidemiology and Data Science, ACS - Diabetes & metabolism, APH - Health Behaviors & Chronic Diseases, General practice, ACS - Heart failure & arrhythmias, APH - Aging & Later Life, Graduate School, and APH - Methodology

Subjects
Biomedical Engineering, Type 2 diabetes, Bioengineering, Applied Microbiology and Biotechnology, Deep Learning, SDG 3 - Good Health and Well-being, Diabetes Mellitus, Type 2, Machine learning, Molecular Medicine, Humans, Data integration, IMI DIRECT Consortium, Systems biology, Algorithms, Biotechnology
Abstract

The application of multiple omics technologies in biomedical cohorts has the potential to reveal patient-level disease characteristics and individualized response to treatment. However, the scale and heterogeneous nature of multi-modal data makes integration and inference a non-trivial task. We developed a deep-learning-based framework, multi-omics variational autoencoders (MOVE), to integrate such data and applied it to a cohort of 789 people with newly diagnosed type 2 diabetes with deep multi-omics phenotyping from the DIRECT consortium. Using in silico perturbations, we identified drug–omics associations across the multi-modal datasets for the 20 most prevalent drugs given to people with type 2 diabetes with substantially higher sensitivity than univariate statistical tests. From these, we among others, identified novel associations between metformin and the gut microbiota as well as opposite molecular responses for the two statins, simvastatin and atorvastatin. We used the associations to quantify drug–drug similarities, assess the degree of polypharmacy and conclude that drug effects are distributed across the multi-omics modalities.

Published
2023

19. A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults

Author

Hansen, Lea B. S., Roager, Henrik M., Søndertoft, Nadja B., Gøbel, Rikke J., Kristensen, Mette, Vallès-Colomer, Mireia, Vieira-Silva, Sara, Ibrügger, Sabine, Lind, Mads V., Mærkedahl, Rasmus B., Bahl, Martin I., Madsen, Mia L., Havelund, Jesper, Falony, Gwen, Tetens, Inge, Nielsen, Trine, Allin, Kristine H., Frandsen, Henrik L., Hartmann, Bolette, Holst, Jens Juul, Sparholt, Morten H., Holck, Jesper, Blennow, Andreas, Moll, Janne Marie, Meyer, Anne S., Hoppe, Camilla, Poulsen, Jørgen H., Carvalho, Vera, Sagnelli, Domenico, Dalgaard, Marlene D., Christensen, Anders F., Lydolph, Magnus Christian, Ross, Alastair B., Villas-Bôas, Silas, Brix, Susanne, Sicheritz-Pontén, Thomas, Buschard, Karsten, Linneberg, Allan, Rumessen, Jüri J., Ekstrøm, Claus T., Ritz, Christian, Kristiansen, Karsten, Nielsen, H. Bjørn, Vestergaard, Henrik, Færgeman, Nils J., Raes, Jeroen, Frøkiær, Hanne, Hansen, Torben, Lauritzen, Lotte, Gupta, Ramneek, Licht, Tine Rask, and Pedersen, Oluf

Published
2018
Full Text
View/download PDF

20. Metabolite ratios as potential biomarkers for type 2 diabetes: a DIRECT study

Author

Molnos, Sophie, Wahl, Simone, Haid, Mark, Eekhoff, E. Marelise W., Pool, René, Floegel, Anna, Deelen, Joris, Much, Daniela, Prehn, Cornelia, Breier, Michaela, Draisma, Harmen H., van Leeuwen, Nienke, Simonis-Bik, Annemarie M. C., Jonsson, Anna, Willemsen, Gonneke, Bernigau, Wolfgang, Wang-Sattler, Rui, Suhre, Karsten, Peters, Annette, Thorand, Barbara, Herder, Christian, Rathmann, Wolfgang, Roden, Michael, Gieger, Christian, Kramer, Mark H. H., van Heemst, Diana, Pedersen, Helle K., Gudmundsdottir, Valborg, Schulze, Matthias B., Pischon, Tobias, de Geus, Eco J. C., Boeing, Heiner, Boomsma, Dorret I., Ziegler, Anette G., Slagboom, P. Eline, Hummel, Sandra, Beekman, Marian, Grallert, Harald, Brunak, Søren, McCarthy, Mark I., Gupta, Ramneek, Pearson, Ewan R., Adamski, Jerzy, and ’t Hart, Leen M.

Published
2017
Full Text
View/download PDF

22. Acquisition of docetaxel resistance in breast cancer cells reveals upregulation of ABCB1 expression as a key mediator of resistance accompanied by discrete upregulation of other specific genes and pathways

Author

Hansen, Stine Ninel, Westergaard, David, Thomsen, Mathilde Borg Houlberg, Vistesen, Mette, Do, Khoa Nguyen, Fogh, Louise, Belling, Kirstine C., Wang, Jun, Yang, Huanming, Gupta, Ramneek, Ditzel, Henrik J., Moreira, José, Brünner, Nils, Stenvang, Jan, and Schrohl, Anne-Sofie

Published
2015
Full Text
View/download PDF

23. Characteristics of white blood cell count in acute lymphoblastic leukemia: A COST LEGEND phenotype–genotype study

Author

Helenius, Marianne, primary, Vaitkeviciene, Goda, additional, Abrahamsson, Jonas, additional, Jonsson, Ólafur Gisli, additional, Lund, Bendik, additional, Harila‐Saari, Arja, additional, Vettenranta, Kim, additional, Mikkel, Sirje, additional, Stanulla, Martin, additional, Lopez‐Lopez, Elixabet, additional, Waanders, Esmé, additional, Madsen, Hans O., additional, Marquart, Hanne Vibeke, additional, Modvig, Signe, additional, Gupta, Ramneek, additional, Schmiegelow, Kjeld, additional, and Nielsen, Rikke Linnemann, additional

Published
2022
Full Text
View/download PDF

24. Large-Scale Functional Genomics Screen to Identify Modulators of Human β-Cell Insulin Secretion

Author

Szczerbinska, Iwona, primary, Tessitore, Annamaria, additional, Hansson, Lena Kristina, additional, Agrawal, Asmita, additional, Ragel Lopez, Alejandro, additional, Helenius, Marianne, additional, Malinowski, Andrzej R., additional, Gilboa, Barak, additional, Ruby, Maxwell A., additional, Gupta, Ramneek, additional, and Ämmälä, Carina, additional

Published
2022
Full Text
View/download PDF

26. An Aboriginal Australian Genome Reveals Separate Human Dispersals into Asia

Author

Rasmussen, Morten, Guo, Xiaosen, Wang, Yong, Lohmueller, Kirk E., Rasmussen, Simon, Albrechtsen, Anders, Skotte, Line, Lindgreen, Stinus, Metspalu, Mait, Jombart, Thibaut, Kivisild, Toomas, Zhai, Weiwei, Eriksson, Anders, Manica, Andrea, Orlando, Ludovic, De La Vega, Francisco M., Tridico, Silvana, Metspalu, Ene, Nielsen, Kasper, Ávila-Arcos, María C., Moreno-Mayar, J. Víctor, Muller, Craig, Dortch, Joe, Gilbert, M. Thomas P., Lund, Ole, Wesolowska, Agata, Karmin, Monika, Weinert, Lucy A., Wang, Bo, Li, Jun, Tai, Shuaishuai, Xiao, Fei, Hanihara, Tsunehiko, van Driem, George, Jha, Aashish R., Ricaut, François-Xavier, de Knijff, Peter, Migliano, Andrea B, Romero, Irene Gallego, Kristiansen, Karsten, Lambert, David M., Brunak, Søren, Forster, Peter, Brinkmann, Bernd, Nehlich, Olaf, Bunce, Michael, Richards, Michael, Gupta, Ramneek, Bustamante, Carlos D., Krogh, Anders, Foley, Robert A., Lahr, Marta M., Balloux, Francois, Sicheritz-Pontén, Thomas, Villems, Richard, Nielsen, Rasmus, Wang, Jun, and Willerslev, Eske

Published
2011
Full Text
View/download PDF

28. Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium

Author

Koivula, Robert W., Heggie, Alison, Barnett, Anna, Cederberg, Henna, Hansen, Tue H., Koopman, Anitra D., Ridderstråle, Martin, Rutters, Femke, Vestergaard, Henrik, Gupta, Ramneek, Herrgård, Sanna, Heymans, Martijn W., Perry, Mandy H., Rauh, Simone, Siloaho, Maritta, Teare, Harriet J. A., Thorand, Barbara, Bell, Jimmy, Brunak, Søren, Frost, Gary, Jablonka, Bernd, Mari, Andrea, McDonald, Tim J., Dekker, Jacqueline M., Hansen, Torben, Hattersley, Andrew, Laakso, Markku, Pedersen, Oluf, Koivisto, Veikko, Ruetten, Hartmut, Walker, Mark, Pearson, Ewan, Franks, Paul W., and for the DIRECT Consortium

Published
2014
Full Text
View/download PDF

30. Can Machine Learning Models Predict Asparaginase-associated Pancreatitis in Childhood Acute Lymphoblastic Leukemia

Author

Nielsen, Rikke L., primary, Wolthers, Benjamin O., additional, Helenius, Marianne, additional, Albertsen, Birgitte K., additional, Clemmensen, Line, additional, Nielsen, Kasper, additional, Kanerva, Jukka, additional, Niinimäki, Riitta, additional, Frandsen, Thomas L., additional, Attarbaschi, Andishe, additional, Barzilai, Shlomit, additional, Colombini, Antonella, additional, Escherich, Gabriele, additional, Aytan-Aktug, Derya, additional, Liu, Hsi-Che, additional, Möricke, Anja, additional, Samarasinghe, Sujith, additional, van der Sluis, Inge M., additional, Stanulla, Martin, additional, Tulstrup, Morten, additional, Yadav, Rachita, additional, Zapotocka, Ester, additional, Schmiegelow, Kjeld, additional, and Gupta, Ramneek, additional

Published
2021
Full Text
View/download PDF

31. Inferring causal pathways between metabolic processes and liver fat accumulation: an IMI DIRECT study

Author

Atabaki-Pasdar, Naeimeh, primary, Pomares-Millan, Hugo, additional, Koivula, Robert W, additional, Tura, Andrea, additional, Brown, Andrew, additional, Viñuela, Ana, additional, Agudelo, Leandro, additional, Coral, Daniel, additional, van Oort, Sabine, additional, Allin, Kristine, additional, Chabanova, Elizaveta, additional, Cederberg, Henna, additional, De Masi, Federico, additional, Elders, Petra, additional, Tajes, Juan Fernandez, additional, Forgie, Ian M, additional, Hansen, Tue H, additional, Heggie, Alison, additional, Jones, Angus, additional, Kokkola, Tarja, additional, Mahajan, Anubha, additional, McDonald, Timothy J, additional, McEvoy, Donna, additional, Tsirigos, Konstantinos, additional, Teare, Harriet, additional, Vangipurapu, Jagadish, additional, Vestergaard, Henrik, additional, Adamski, Jerzy, additional, Beulens, Joline WJ, additional, Brunak, Søren, additional, Dermitzakis, Emmanouil, additional, Hansen, Torben, additional, Hattersley, Andrew T, additional, Laakso, Markku, additional, Pedersen, Oluf, additional, Ridderstråle, Martin, additional, Ruetten, Hartmut, additional, Rutters, Femke, additional, Schwenk, Jochen M, additional, Walker, Mark, additional, Giordano, Giuseppe N, additional, Ohlsson, Mattias, additional, Gupta, Ramneek, additional, Mari, Andrea, additional, McCarthy, Mark I, additional, Thomas, E Louise, additional, Bell, Jimmy D, additional, Pavo, Imre, additional, Pearson, Ewan R, additional, and Franks, Paul W, additional

Published
2021
Full Text
View/download PDF

33. Establishment and characterization of models of chemotherapy resistance in colorectal cancer: Towards a predictive signature of chemoresistance

Author

Jensen, Niels F., Stenvang, Jan, Beck, Mette K., Hanáková, Barbora, Belling, Kirstine C., Do, Khoa N., Viuff, Birgitte, Nygård, Sune B., Gupta, Ramneek, Rasmussen, Mads H., Tarpgaard, Line S., Hansen, Tine P., Budinská, Eva, Pfeiffer, Per, Bosman, Fred, Tejpar, Sabine, Roth, Arnaud, Delorenzi, Mauro, Andersen, Claus L., Rmer, Maria U., Brünner, Nils, and Moreira, José M.A.

Published
2015
Full Text
View/download PDF

35. Novel variation and de novo mutation rates in population-wide de novo assembled Danish trios

Author

Besenbacher, Søren, Liu, Siyang, Izarzugaza, José M. G., Grove, Jakob, Belling, Kirstine, Bork-Jensen, Jette, Huang, Shujia, Als, Thomas D., Li, Shengting, Yadav, Rachita, Rubio-García, Arcadio, Lescai, Francesco, Demontis, Ditte, Rao, Junhua, Ye, Weijian, Mailund, Thomas, Friborg, Rune M., Pedersen, Christian N. S., Xu, Ruiqi, Sun, Jihua, Liu, Hao, Wang, Ou, Cheng, Xiaofang, Flores, David, Rydza, Emil, Rapacki, Kristoffer, Damm Sørensen, John, Chmura, Piotr, Westergaard, David, Dworzynski, Piotr, Sørensen, Thorkild I. A., Lund, Ole, Hansen, Torben, Xu, Xun, Li, Ning, Bolund, Lars, Pedersen, Oluf, Eiberg, Hans, Krogh, Anders, Børglum, Anders D., Brunak, Søren, Kristiansen, Karsten, Schierup, Mikkel H., Wang, Jun, Gupta, Ramneek, Villesen, Palle, and Rasmussen, Simon

Published
2015
Full Text
View/download PDF

36. Information theoretic perspective on genome clustering

Author

Veluchamy, Alaguraj, primary, Mehta, Preeti, additional, Srividhya, K.V., additional, Vikram, Hirendra, additional, Govind, M.K., additional, Gupta, Ramneek, additional, Aziz Bin Dukhyil, Abdul, additional, Abdullah Alharbi, Raed, additional, Abdullah Aloyuni, Saleh, additional, Hassan, Mohamed M., additional, and Krishnaswamy, S., additional

Published
2021
Full Text
View/download PDF

38. Identification of 22 novel loci associated with susceptibility to testicular germ cell tumors

Author

Pluta, John B., Pyle, Louise C., Bishop, D. Timothy, Benitez, Javier, Cortessis, Victoria K., Ferlin, Alberto, Gietema, Jourik A., Greene, Mark H., Grotmol, Tom, Gupta, Ramneek, Hamilton, Robert M, Hildebrandt, Michelle, Kiemeney, Lambertus A, Lessel, Davor, Rafnar, Thorunn, Richiardi, Lorenzo, Skotheim, Rolf I., Turnbull, Clare, Wiklund, Fredrik, Zheng, Tongzhang, Rajpert-De Meyts, Ewa, Schwartz, Stephen M., McGlynn, Katherine A., Kanetsky, Peter A, Nathanson, Katherine L., Guided Treatment in Optimal Selected Cancer Patients (GUTS), and Damage and Repair in Cancer Development and Cancer Treatment (DARE)

Abstract

Background: Testicular germ cell tumors (TGCT) are the most common cancers in young men of European ancestry aged 20 to 39 years. The incidence of TGCT has doubled over the past 20 years, yet no robust environmental risk factors for disease have been identified. Although TGCTs are treatable by surgery, radiation, and platinum-based chemotherapy, multiple long-term toxicities of treatment often occur impacting morbidity and mortality. Due to their high heritability and homogenous cell of origin, TGCTs are well suited to genome-wide association methods. The Testicular Cancer Consortium (TECAC) has brought together the largest genome-wise association study (GWAS) study of TGCT to date. Methods: We conducted a GWAS of 5,602 cases and 5,006 controls aggregated from 12 locations in the US and Europe. Logistic regression models adjusted for study center and genomic ancestry. Genotypes were imputed against the Human Haplotype Reference Consortium. Meta-analysis was performed to combine GWAS results with summary statistics from five previously published TGCT studies, UK Biobank, deCODE Genetics, and an independent set of cases and controls, for a total of 10,156 cases and 179,683 controls. Biologic function of loci was explored using PAINTOR annotated with ATAC-seq data of four TGCT cell lines, SPATIAL-seq data of the NTERA2 TGCT cell-line, and publicly available data from ENCODE. Polygenic risk scores (PRS) were computed using subject-level data from the 5,602 cases and 5,006 controls, and effect sizes of the novel hits derived from the meta-analysis. Results: 22 novel and 45 previously reported loci associated with TGCT surpassed genome-wide significance (p < 5e-08). We discovered additional markers in known susceptibility loci and identified novel regions associated with germ cell development and sex determination (e.g., BCL11, AR), immune function (e.g., TNXB, ITIH5), and for the first time identified genes associated with kinetochore activity (e.g., PPP2R5A, ANAPC2). All identified risk SNPs to date account for 42.3% of heritability. Men in the highest 1% of PRS had over a 15-fold increased risk of TGCT compared to those at the median PRS, and PRS overall had an AUC of 74.29%. Conclusions: Results from our TGCT meta-analysis continue to provide insights into biological pathways affecting germ cell specification, expression, and epigenetic reprogramming, and sex determination. Our results also uniquely place TGCT as the only cancer type in which inherited variants implicating kinetochore activity, critical for chromosomal segregation, have been identified. Citation Format: John Pluta, Louisa Pyle, Timothy Bishop, Javier Benitez, Victoria Cortessis, Alberto Ferlin, Jourik Gietema, Mark Greene, Thomas Grotmol, Ramneek Gupta, Robert Hamilton, Michelle Hildebrandt, Lambertus Kiemeney, Davor Lessel, Thorunn Rafnar, Lorenzo Richiardi, Rolf Skotheim, Clare Turnbull, Fredrik Wiklund, Tongzhang Zheng, Ewa Rajpert- De Meyts, Stephen Schwartz, Katherine McGlynn, Peter Kanetsky, Katherine Nathanson. Identification of 22 novel loci associated with susceptibility to testicular germ cell tumors [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 1203.

Published
2020

39. Effects of germline variants in DHFR and FPGS on methotrexate metabolism and relapse of leukemia

Author

Tulstrup, Morten, Moriyama, Takaya, Jiang, Chuang, Grosjean, Marie, Nersting, Jacob, Abrahamsson, Jonas, Grell, Kathrine, Lyngsie Hjalgrim, Lisa, Jonsson, Olafur G, Kanerva, Jukka, Lund, Bendik, Nielsen, Stine Nygaard, Nielsen, Rikke Linnemann, Overgaard, Ulrik, Quist-Paulsen, Petter, Pruunsild, Kaie, Vaitkeviciene, Goda, Wolthers, Benjamin Ole, Zhang, Hui, Gupta, Ramneek, Yang, Jun J, and Schmiegelow, Kjeld

Abstract

Methotrexate (MTX) during maintenance therapy is essential to cure acute lymphoblastic leukemia (ALL), but dosing strategies to achieve adequate treatment intensity are challenged by inter-individual differences in drug disposition. To evaluate genetic factors associated with MTX metabolism, we performed a genome-wide association study in 447 ALL cases from the Nordic Society for Paediatric Haematology and Oncology ALL2008 study, validating results in an independent set of 196 patients. The intergenic SNP rs1382539 located in a regulatory element of DHFR was associated with increased levels of short-chain MTX polyglutamates (P = 1.1 × 10-8) due to suppression of enhancer activity, while rs35789560 in FPGS (p.R466C, P = 5.6 × 10-9) was associated with decreased levels of long-chain MTX polyglutamates through reduced catalytic activity. Furthermore, the FPGS variant was linked with increased relapse risk (P = 0.044). These findings show a genetic basis for inter-patient variability in MTX response and could be used to improve future dosing algorithms.

Published
2020

40. Sequencing and de novo assembly of 150 genomes from Denmark as a population reference

Author

Maretty, Lasse, Jensen, Jacob Malte, Petersen, Bent, Sibbesen, Jonas Andreas, Liu, Siyang, Villesen, Palle, Skov, Laurits, Belling, Kirstine, Theil Have, Christian, Izarzugaza, Jose M. G., Grosjean, Marie, Bork-Jensen, Jette, Grove, Jakob, Als, Thomas D., Huang, Shujia, Chang, Yuqi, Xu, Ruiqi, Ye, Weijian, Rao, Junhua, Guo, Xiaosen, Sun, Jihua, Cao, Hongzhi, Ye, Chen, van Beusekom, Johan, Espeseth, Thomas, Flindt, Esben, Friborg, Rune M., Halager, Anders E., Le Hellard, Stephanie, Hultman, Christina M., Lescai, Francesco, Li, Shengting, Lund, Ole, Lngren, Peter, Mailund, Thomas, Matey-Hernandez, Maria Luisa, Mors, Ole, Pedersen, Christian N. S., Sicheritz-Pontn, Thomas, Sullivan, Patrick, Syed, Ali, Westergaard, David, Yadav, Rachita, Li, Ning, Xu, Xun, Hansen, Torben, Krogh, Anders, Bolund, Lars, Srensen, Thorkild I. A., Pedersen, Oluf, Gupta, Ramneek, Rasmussen, Simon, Besenbacher, Sren, Brglum, Anders D., Wang, Jun, Eiberg, Hans, Kristiansen, Karsten, Brunak, Sren, and Schierup, Mikkel Heide

Subjects
DNA sequencing -- Methods, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Lasse Maretty [1]; Jacob Malte Jensen [2, 3]; Bent Petersen [4]; Jonas Andreas Sibbesen [1]; Siyang Liu [1, 5]; Palle Villesen [2, 3, 6]; Laurits Skov [2, 3]; Kirstine [...]

Published
2017
Full Text
View/download PDF

41. Nationwide germline whole genome sequencing of 198 consecutive pediatric cancer patients reveals a high incidence of cancer prone syndromes

Author

Byrjalsen, Anna, primary, Hansen, Thomas V. O., additional, Stoltze, Ulrik K., additional, Mehrjouy, Mana M., additional, Barnkob, Nanna Moeller, additional, Hjalgrim, Lisa L., additional, Mathiasen, René, additional, Lautrup, Charlotte K., additional, Gregersen, Pernille A., additional, Hasle, Henrik, additional, Wehner, Peder S., additional, Tuckuviene, Ruta, additional, Sackett, Peter Wad, additional, Laspiur, Adrian O., additional, Rossing, Maria, additional, Marvig, Rasmus L., additional, Tommerup, Niels, additional, Olsen, Tina Elisabeth, additional, Scheie, David, additional, Gupta, Ramneek, additional, Gerdes, Anne–Marie, additional, Schmiegelow, Kjeld, additional, and Wadt, Karin, additional

Published
2020
Full Text
View/download PDF

42. Polygenic risk score-analysis of thromboembolism in patients with acute lymphoblastic leukemia

Author

Jarvis, Kirsten Brunsvig, primary, Nielsen, Rikke Linnemann, additional, Gupta, Ramneek, additional, Hede, Freja Dahl, additional, Huttunen, Pasi, additional, Jónsson, Ólafur Gisli, additional, Rank, Cecilie Utke, additional, Ranta, Susanna, additional, Saks, Kadri, additional, Trakymiene, Sonata Saulyte, additional, Tuckuviene, Ruta, additional, Tulstrup, Morten, additional, Ruud, Ellen, additional, Schmiegelow, Kjeld, additional, and LeBlanc, Marissa, additional

Published
2020
Full Text
View/download PDF

45. A genome-wide association study of men with symptoms of testicular dysgenesis syndrome and its network biology interpretation

Author

Dalgaard, Marlene D, Weinhold, Nils, Edsgärd, Daniel, Silver, Jeremy D, Pers, Tune H, Nielsen, John E, Jørgensen, Niels, Juul, Anders, Gerds, Thomas A, Giwercman, Aleksander, Giwercman, Yvonne L, Cohn-Cedermark, Gabriella, Virtanen, Helena E, Toppari, Jorma, Daugaard, Gedske, Jensen, Thomas S, Brunak, Søren, Rajpert-De Meyts, Ewa, Skakkebæk, Niels E, Leffers, Henrik, and Gupta, Ramneek

Published
2012
Full Text
View/download PDF

46. The intestinal microbiome is a co-determinant of the postprandial plasma glucose response

Author

Søndertoft, Nadja B., primary, Vogt, Josef K., additional, Arumugam, Manimozhiyan, additional, Kristensen, Mette, additional, Gøbel, Rikke J., additional, Fan, Yong, additional, Lyu, Liwei, additional, Bahl, Martin I., additional, Eriksen, Carsten, additional, Ängquist, Lars, additional, Frøkiær, Hanne, additional, Hansen, Tue H., additional, Brix, Susanne, additional, Nielsen, H. Bjørn, additional, Hansen, Torben, additional, Vestergaard, Henrik, additional, Gupta, Ramneek, additional, Licht, Tine R., additional, Lauritzen, Lotte, additional, and Pedersen, Oluf, additional

Published
2020
Full Text
View/download PDF

47. Effects of germline DHFR and FPGS variants on methotrexate metabolism and relapse of leukemia

Author

Tulstrup, Morten, primary, Moriyama, Takaya, additional, Jiang, Chuang, additional, Grosjean, Marie, additional, Nersting, Jacob, additional, Abrahamsson, Jonas, additional, Grell, Kathrine, additional, Hjalgrim, Lisa Lyngsie, additional, Jónsson, Ólafur Gísli, additional, Kanerva, Jukka, additional, Lund, Bendik, additional, Nielsen, Stine Nygaard, additional, Nielsen, Rikke Linnemann, additional, Overgaard, Ulrik, additional, Quist-Paulsen, Petter, additional, Pruunsild, Kaie, additional, Vaitkeviciene, Goda, additional, Wolthers, Benjamin Ole, additional, Zhang, Hui, additional, Gupta, Ramneek, additional, Yang, Jun J., additional, and Schmiegelow, Kjeld, additional

Published
2020
Full Text
View/download PDF

48. Abstract 1203: Identification of 22 novel loci associated with susceptibility to testicular germ cell tumors

Author

Pluta, John, primary, Pyle, Louisa, additional, Bishop, Timothy, additional, Benitez, Javier, additional, Cortessis, Victoria, additional, Ferlin, Alberto, additional, Gietema, Jourik, additional, Greene, Mark, additional, Grotmol, Thomas, additional, Gupta, Ramneek, additional, Hamilton, Robert, additional, Hildebrandt, Michelle, additional, Kiemeney, Lambertus, additional, Lessel, Davor, additional, Rafnar, Thorunn, additional, Richiardi, Lorenzo, additional, Skotheim, Rolf, additional, Turnbull, Clare, additional, Wiklund, Fredrik, additional, Zheng, Tongzhang, additional, De Meyts, Ewa Rajpert-, additional, Schwartz, Stephen, additional, McGlynn, Katherine, additional, Kanetsky, Peter, additional, and Nathanson, Katherine, additional

Published
2020
Full Text
View/download PDF

49. Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts

Author

Atabaki-Pasdar, Naeimeh, primary, Ohlsson, Mattias, additional, Viñuela, Ana, additional, Frau, Francesca, additional, Pomares-Millan, Hugo, additional, Haid, Mark, additional, Jones, Angus G., additional, Thomas, E. Louise, additional, Koivula, Robert W., additional, Kurbasic, Azra, additional, Mutie, Pascal M., additional, Fitipaldi, Hugo, additional, Fernandez, Juan, additional, Dawed, Adem Y., additional, Giordano, Giuseppe N., additional, Forgie, Ian M., additional, McDonald, Timothy J., additional, Rutters, Femke, additional, Cederberg, Henna, additional, Chabanova, Elizaveta, additional, Dale, Matilda, additional, Masi, Federico De, additional, Thomas, Cecilia Engel, additional, Allin, Kristine H., additional, Hansen, Tue H., additional, Heggie, Alison, additional, Hong, Mun-Gwan, additional, Elders, Petra J. M., additional, Kennedy, Gwen, additional, Kokkola, Tarja, additional, Pedersen, Helle Krogh, additional, Mahajan, Anubha, additional, McEvoy, Donna, additional, Pattou, Francois, additional, Raverdy, Violeta, additional, Häussler, Ragna S., additional, Sharma, Sapna, additional, Thomsen, Henrik S., additional, Vangipurapu, Jagadish, additional, Vestergaard, Henrik, additional, ‘t Hart, Leen M., additional, Adamski, Jerzy, additional, Musholt, Petra B., additional, Brage, Soren, additional, Brunak, Søren, additional, Dermitzakis, Emmanouil, additional, Frost, Gary, additional, Hansen, Torben, additional, Laakso, Markku, additional, Pedersen, Oluf, additional, Ridderstråle, Martin, additional, Ruetten, Hartmut, additional, Hattersley, Andrew T., additional, Walker, Mark, additional, Beulens, Joline W. J., additional, Mari, Andrea, additional, Schwenk, Jochen M., additional, Gupta, Ramneek, additional, McCarthy, Mark I., additional, Pearson, Ewan R., additional, Bell, Jimmy D., additional, Pavo, Imre, additional, and Franks, Paul W., additional

Published
2020
Full Text
View/download PDF

50. Genome-Wide Association Meta-Analysis of Single-Nucleotide Polymorphisms and Symptomatic Venous Thromboembolism during Therapy for Acute Lymphoblastic Leukemia and Lymphoma in Caucasian Children

Author

Mateos, Marion K., primary, Tulstrup, Morten, additional, Quinn, Michael CJ, additional, Tuckuviene, Ruta, additional, Marshall, Glenn M., additional, Gupta, Ramneek, additional, Mayoh, Chelsea, additional, Wolthers, Benjamin O., additional, Barbaro, Pasquale M., additional, Ruud, Ellen, additional, Sutton, Rosemary, additional, Huttunen, Pasi, additional, Revesz, Tamas, additional, Trakymiene, Sonata S., additional, Barbaric, Draga, additional, Tedgård, Ulf, additional, Giles, Jodie E., additional, Alvaro, Frank, additional, Jonsson, Olafur G., additional, Mechinaud, Françoise, additional, Saks, Kadri, additional, Catchpoole, Daniel, additional, Kotecha, Rishi S., additional, Dalla-Pozza, Luciano, additional, Chenevix-Trench, Georgia, additional, Trahair, Toby N., additional, MacGregor, Stuart, additional, and Schmiegelow, Kjeld, additional

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results