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254 results on '"Gupta, Gurudutt"'

2. Adrenal ganglioneuroma with retroperitoneal lymph node metastasis: A rare scenario

Author

Kamboj, Meenakshi, Gupta, Gurudutt, Pasricha, Sunil, Sharma, Anila, and Durga, Garima

Subjects
Diagnosis, Care and treatment, Physiological aspects, Case studies, Health aspects, Adrenal glands -- Physiological aspects -- Health aspects, Pediatric tumors -- Diagnosis -- Care and treatment -- Case studies, Neuroectodermal tumors -- Diagnosis -- Care and treatment -- Case studies, Tumors in children -- Diagnosis -- Care and treatment -- Case studies
Abstract

Author(s): Meenakshi Kamboj (corresponding author) [1]; Gurudutt Gupta [1]; Sunil Pasricha [1]; Anila Sharma [1]; Garima Durga [1] INTRODUCTION Ganglioneuroma (GN) is a benign tumor of neural crest origin, most [...], Ganglioneuroma (GN) is the most differentiated and benign variant of neuroblastic tumors, most commonly located in the posterior mediastinum, followed by the retroperitoneum and adrenal gland. Children of Keywords: Adrenal gland, ganglioneuroma, metastatic

Published
2024
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3. Extranodal follicular dendritic cell sarcoma presenting as colonic mass: A diagnostic and therapeutic challenge

Author

Pasricha, Sunil, Durga, Garima, Sharma, Anila, Jajodia, Ankush, Singh, Shivendra, Gupta, Gurudutt, Kamboj, Meenakshi, Koyyala, Venkata Pradeep Babu, Gupta, Manoj, and Mehta, Anurag

Subjects
Diagnosis, Case studies, Health aspects, Sarcoma -- Case studies -- Diagnosis, Dendritic cells -- Case studies -- Health aspects, Gastrointestinal tumors -- Case studies -- Diagnosis
Abstract

Author(s): Sunil Pasricha [1]; Garima Durga (corresponding author) [1]; Anila Sharma [1]; Ankush Jajodia [2]; Shivendra Singh [3]; Gurudutt Gupta [1]; Meenakshi Kamboj [1]; Venkata Pradeep Babu Koyyala [4]; Manoj [...], Folliclular dendritic cell sarcoma (FDCS) is an extremely rare neoplasm originating from folliclular dendritic cells, both nodally and extranodally. Its primary presentation as a large colonic mass is rare and can be misdiagnosed as epithelial tumor/soft tissue tumor both clinically and through histomorphology. Due to its rarity and limited consensus guidelines about its management, it presents as a diagnostic and therapeutic challenge for pathologists and oncologists. However, accurate diagnosis is imperative due to its distinct prognostic and therapeutic implications. Herein we report, two cases of extranodal FDCS of colon with the aim of contributing to the management of this uncommon entity. Keywords: CD21, CD23, folliclular dendritic cell sarcoma, gastrointestinal tract

Published
2024
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7. Metastatic choriocarcinoma of the kidney in the absence of existing primary uterine tumor: A rare presentation

Author

Pahwa, Saloni, Sharma, Anila, Kamboj, Meenakshi, Gupta, Gurudutt, and Pasricha, Sunil

Subjects
Diagnosis, Care and treatment, Choriocarcinoma -- Diagnosis -- Care and treatment
Abstract

Author(s): Saloni Pahwa (corresponding author) [1]; Anila Sharma [1]; Meenakshi Kamboj [1]; Gurudutt Gupta [1]; Sunil Pasricha [1] INTRODUCTION Gestational trophoblastic neoplasms (GTNs) are a rare group of gestational trophoblastic [...], Gestational choriocarcinomas are malignant neoplasms generally arising in the uterus in women of childbearing age. These are aggressive tumors with a high incidence of metastasis to vascular organs such as the lung, liver, and brain. Renal metastasis is extremely rare with low incidence rate and very few cases have been reported in literature. Hereby, we report a rare case of metastatic choriocarcinoma to the kidney in a 29-year-old female 10 years after resection of a hydatidiform mole. The histopathological diagnosis was made on a nephrectomy specimen. Pelvic and abdominal scan did not show any abnormal radiological findings. She was started on first-line chemotherapy and showed a complete response. In conclusion, gestational or primary nongestational choriocarcinomas should always be considered as a differential diagnosis in young females of reproductive age group presenting with flank abdominal pain, unexplained hematuria, and atypical renal tumor histology. Keywords: Chemotherapy, gestational choriocarcinoma, hydatidiform mole, metastasis

Published
2023
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11. Primary pulmonary NUT midline carcinoma: An elusive and a rare diagnostic entity

Author

Pasricha, Sunil, Jajodia, Ankush, Sharma, Anila, Bansal, Divya, Batra, Ullas, Gupta, Gurudutt, Durga, Garima, Kamboj, Meenakshi, Nathany, Shrinidhi, and Mehta, Anurag

Subjects
Diagnosis, Care and treatment, Health aspects, Testis -- Health aspects, Carcinoma -- Diagnosis -- Care and treatment, Proteins -- Health aspects, Cancer -- Diagnosis -- Care and treatment
Abstract

Author(s): Sunil Pasricha [1]; Ankush Jajodia [2]; Anila Sharma [1]; Divya Bansal (corresponding author) [1]; Ullas Batra [3]; Gurudutt Gupta [1]; Garima Durga [1]; Meenakshi Kamboj [1]; Shrinidhi Nathany [4]; [...], Nuclear protein in testis (NUT) midline carcinoma is a poorly differentiated tumor, is more common in midline anatomic sites, and involves young adults and children mainly. Primary pulmonary NUT midline carcinoma (NMC) is a rare and poorly defined entity in the prevailing literature. Being a highly aggressive and fatal neoplasm, it gets incumbent for the oncologists and the pathologists to be aware of this entity as it holds distinct management protocol and prognosis. Currently, BET inhibitors (BETi) and histone deactylase inhibitors have shown promising results as targeted therapies in clinical trials in head and neck NMC. We present a case report of NMC of primary pulmonary location in a young male with widespread bony metastasis. Keywords: Mediastinum, metastasis, nuclear protein in testis midline carcinoma, pulmonary, radiotherapy

Published
2023
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18. Fumarate hydratase–deficient renal cell carcinoma: an oncology care institutional experience.

Author

Kamboj, Meenakshi, Gupta, Gurudutt, Pasricha, Sunil, Mehta, Anurag, Rawal, Sudhir, Singh, Amitabh, Sharma, Anila, Durga, Garima, Bansal, Divya, and Diwan, Himanshi

Subjects
*RENAL cell carcinoma, *INSTITUTIONAL care, *CANCER treatment, *RENAL cancer, *KIDNEY tumors, *BREAST
Abstract

Renal cell carcinoma (RCC) accounts for 2% of all cancer cases worldwide, and majority are sporadic. The latest World Health Organization (WHO) classification of renal cell tumors (fifth edition, 2022) has molecularly defined renal tumor entities, which includes fumarate hydratase (FH)–deficient RCC. FH‐deficient RCC is an aggressive carcinoma caused by pathogenic alterations in FH gene, seen in 15% of patients with hereditary leiomyomatosis and renal cell cancer syndrome (HLRCC) syndrome. These tumors occur more frequently at a younger age and present at an advanced stage, carrying a dismal prognosis. We report a series of 10 cases of FH‐deficient RCC. The mean age was 49.8 years, and all cases presented in advanced stages (III and IV). Morphologically, the cases had varied architectural patterns with characteristic eosinophilic macronucleoli and perinucleolar halo. On immunohistochemistry (IHC), all showed diffuse nucleo‐cytoplasmic expression of S‐(2‐succino)‐cysteine (2‐SC), with loss of FH in seven cases. FH‐deficient RCCs are aggressive neoplasms and can be diagnosed using specific IHC markers (FH and 2‐SC). These patients should undergo germline testing for FH gene mutation, genetic counseling, and surveillance of family members. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Optimization of Tissue Handling and Processing in the Era of Precision Medicine: A Practical Recommendation from a Multidisciplinary Panel of Indian Experts

Author

Kaushal, Rajiv Kumar, additional, Menon, Santosh, additional, Shetty, Omshree, additional, Shet, Tanuja, additional, Desai, Sangeeta, additional, Mehta, Anurag, additional, Choughule, Anuradha, additional, Biswas, Bivas, additional, Midha, Divya, additional, Gupta, Gurudutt, additional, Ghosh, Jaya, additional, Mehta, Jay, additional, Prabhash, Kumar, additional, Nadeem, Sayed Mahmood, additional, Somashekhar, S P., additional, Joshi, Ujwala, additional, Ramaswamy, Veena, additional, Koppula, Veeraiah, additional, and Gupta, Sudeep, additional

Published
2023
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22. PD-L1 Testing and Assessment: Practical Considerations for Oncologist and Pathologist.

Author

Pasricha, Sunil, Durga, Garima, Koyyala, Venkata Pradeep Babu, Jajodia, Ankush, Gupta, Gurudutt, and Mehta, Anurag

Subjects
PROGRAMMED death-ligand 1, PATHOLOGISTS, LOBULAR carcinoma
Abstract

This document provides a comprehensive overview of PD-L1 testing and assessment for oncologists and pathologists. It explains the importance of PD-L1 immunohistochemistry (IHC) testing as a predictive biomarker for immune checkpoint inhibitors. The article discusses the three most commonly used PD-L1 IHC assays and their platforms, as well as the different scoring methods used to assess PD-L1 immunoexpression. It also outlines the clinical settings for PD-L1 testing, including companion diagnostic tests and complementary diagnostic tests. The document emphasizes the need for further research to fully understand the limitations and precise role of PD-L1 testing in predicting response to immune checkpoint inhibitor therapy. [Extracted from the article]

Published
2024
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23. Multifocal primary pseudomyogenic hemangioendothelioma of bone managed with denosumab: A rare case with diagnostic and therapeutic challenge

Author

Pasricha, Sunil, Sharma, Anila, Pruthi, Manish, Durga, Garima, Jajodia, Ankush, Gupta, Gurudutt, Kamboj, Meenakshi, Gupta, Manoj, and Mehta, Anurag

Subjects
Diagnosis, Drug therapy, Case studies, Dosage and administration, Denosumab -- Case studies -- Dosage and administration, Bone tumors -- Case studies -- Diagnosis -- Drug therapy, Hemangioendothelioma -- Case studies -- Diagnosis -- Drug therapy
Published
2022

28. Correlation NKX2.2 IHC and EWSR1 break-apart FISH in the diagnosis of Ewing sarcoma: Can combined NKX2.2 and CD99 immunoexpression obviate or minimize the need of FISH testing? First assessment study from Indian tertiary cancer care center

Author

Pahwa, Saloni, primary, Pasricha, Sunil, additional, Pruthi, Manish, additional, Jajodia, Ankush, additional, Gupta, Gurudutt, additional, Sharma, Anila, additional, Durga, Garima, additional, Kamboj, Meenakshi, additional, Tiwari, Akshay, additional, Panigrahi, Manoj, additional, and Mehta, Anurag, additional

Published
2023
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46. Pulmonary actinomycosis in fine needle aspiration cytology

Author

Patel Keyuri, Gupta Gurudutt, Shah Menka, and Patel Purvesh

Subjects
Actinomycosis, guided fine needle aspiration cytology, pulmonary., Cytology, QH573-671
Abstract

Pulmonary actinomycosis is a rare bacterial lung disease caused by one of two types of bacteria, Actinomyces or Propioni. Pulmonary actinomycosis in the lung causes lung cavities, lung nodules, and pleural effusion. We report here a case of pulmonary actinomycosis that was diagnosed by fine needle aspiration cytology (FNAC). A 45 year-old male with a history of smoking and alcohol abuse, presented with complaints of cough with hemoptysis, right-sided chest pain, and fever of two months′ duration. A chest radiograph and computed tomography (CT) of the thorax showed a right upper lobe mass lesion with hilar lymphadenopathy. CT-guided FNAC revealed colonies of Actinomyces surrounded by polymorphs. The disease is commonly confused with other chronic suppurative lung diseases and malignancy. An early diagnosis by FNAC prevents difficulties in the management of the disease, as well as considerable physiological and physical morbidity, including unwarranted surgery.

Published
2009

48. Reliability and Role of Mutation-specific H3F3A (Histone 3-3) G34W Immunohistochemistry to Differentiate Giant Cell Tumor of Bone From its Clinicoradiologic and Histologic Mimics: An Institutional Study

Author

Pasricha, Sunil, primary, Pruthi, Manish, additional, Jajodia, Ankush, additional, Kumar, Ankur, additional, Gupta, Gurudutt, additional, Sharma, Anila, additional, Tiwari, Akshay, additional, Rohela, Himanshu, additional, Durga, Garima, additional, Kamboj, Meenakshi, additional, Koyyala, Venkata P.B., additional, and Mehta, Anurag, additional

Published
2021
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