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We present the high-resolution Parkfield matched filter relocated earthquake (PKD-MR) catalog for the 2004 Mw 6 Parkfield earthquake sequence in central California. We use high-quality seismic data recorded by the borehole High Resolution Seismic Network combined with matched filter detection and relocations from cross-correlation derived differential travel times. We determine the magnitudes of newly detected events by computing the amplitude ratio between the detections and templates using a principal component fit. The relocated catalog spans from 6 November 2003 to 28 March 2005 and contains 13,914 earthquakes, which is about three times the number of events listed in the Northern California Seismic Network catalog. Our results on the seismicity rate changes before the 2004 mainshock do not show clear precursory signals, although we find an increase in the seismic activity in the creeping section of the San Andreas fault (SAF) (about ∼30 km northwest of the mainshock epicenter) in the weeks prior to the mainshock. We also observe a decrease in the b-value parameter in the Gutenberg–Richter relationship in the creeping section in the weeks prior to the mainshock. Our results suggest stress is increasingly released seismically in the creeping section, accompanied by a decreasing aseismic creeping rate before the mainshock occurrence. However, b-value and seismicity rates remain stable in the Parkfield section where the 2004 mainshock ruptured. This updated catalog can be used to study the evolution of aftershocks and their relations to afterslip following the 2004 Parkfield mainshock, seismicity before the mainshock, and how external stresses interact with the Parkfield section of the SAF and the 2004 sequence.

The 1989 Mw 6.9 Loma Prieta earthquake is the first major event to occur along the San Andreas fault (SAF) zone in central California since the 1906 M 7.9 San Francisco earthquake. Given the complexity of this event, uncertainty has persisted as to whether this earthquake ruptured the SAF itself or a secondary fault. Recent work on the SAF in the Coachella Valley in southern California has revealed similar complexity, arising from a nonplanar, nonvertical fault geometry, and has led us to reexamine the Loma Prieta event. We have compiled data sets and data analyses in the vicinity of the Loma Prieta earthquake, including the 3D seismic velocity model and aftershock relocations of Lin and Thurber (2012), potential field data collected by the U.S. Geological Survey following the earthquake, and seismic refraction and reflection data from the 1991 profile of Catchings et al. (2004). The velocity model and aftershock relocations of Lin and Thurber (2012) reveal a geometry for the SAF that appears similar to that in the Coachella Valley (although rotated 180°): at Loma Prieta the fault dips steeply near the surface and curves with depth to join the moderately southwest-dipping main rupture below 6 km depth, itself also nonplanar. The SAF is a clear velocity boundary, with higher velocities on the northeast, attributable to Mesozoic accretionary and other rocks, and lower velocities on the southwest, attributable to Cenozoic sedimentary and volcanic rocks of the La Honda block. Rocks of the La Honda block have been offset right-laterally hundreds of kilometers from similar rocks in the southern San Joaquin Valley and vicinity, providing evidence that the curved northeast fault boundary of this block is the plate boundary. Thus, we interpret that the Loma Prieta earthquake occurred on the SAF and not on a secondary fault.

The Eastern Aleutian-Alaska Subduction Zone (EAASZ) manifests significant along-strike variations in structure and geometry. The limited spatial resolution in intermediate-depth earthquake locations precludes investigation of small-scale variations in seismic characteristics. In this study, we use an existing 3D seismic velocity model and waveform cross-correlation data to relocate the earthquakes in 2016 near the EAASZ. Our improved absolute and relative earthquake locations reveal complex spatial characteristics of double seismic zones (DSZs). There are significant variations in location, depth, layer separation, and length of the DSZs along the EAASZ. We also observe nonuniform layer separations along the slope of the subducting slab that may imply either rheological or crustal thickness variations. In addition, our results suggest a triple seismic zone (TSZ) beneath Kenai. The interplay among different factors, including dehydration of metamorphic facies, intraslab stress, preexisting structures, and abrupt changes in slab geometry, may explain the observed variations in seismogenesis of the DSZs and TSZs. The comparison of our relocated seismicity with the thermal model for the slab beneath Cook Inlet shows that the intermediate-depth earthquakes occur between 500°C and 900°C isotherms. The 2016 Mw 7.1 Iniskin earthquake and its aftershocks are located at ∼800°C–900°C. The intricate small-scale variations in different characteristics of the DSZs and intermediate-depth seismicity and their correlations with major geometrical and physical controls can provide insight into what governs the seismogenesis of subduction-induced earthquakes.

SUMMARY In the Gulf of California, Mexico, the relative motion across the North America–Pacific boundary is accommodated by a series of marine transform faults and spreading centres. About 40 M> 6 earthquakes have occurred in the region since 1960. On 2009 August 3, an Mw 6.9 earthquake occurred near Canal de Ballenas in the region. The earthquake was a strike-slip event with a shallow hypocentre that is likely close to the seafloor. In contrast to an adjacent M7 earthquake, this earthquake triggered a ground-motion-based earthquake early warning algorithm being tested in southern California (∼600 km away). This observation suggests that the abnormally large ground motions and dynamic strains observed for this earthquake relate to its rupture properties. To investigate this possibility, we image the rupture process and resolve the slip distribution of the event using a P-wave backprojection approach and a teleseismic, finite-fault inversion method. Results from these two independent analyses indicate a relatively simple, unilateral rupture propagation directed along-strike in the northward direction. However, the average rupture speed is estimated around 4 km s−1, suggesting a possible supershear rupture. The supershear speed is also supported by a Rayleigh wave Mach cone analysis, although uncertainties in local velocity structure preclude a definitive conclusion. The Canal de Ballenas earthquake dynamically triggered seismicity at multiple sites in California, with triggering response characteristics varying from location-to-location. For instance, some of the triggered earthquakes in California occurred up to 24 hr later, suggesting that nonlinear triggering mechanisms likely have modulated their occurrence.

SUMMARY We present our estimations and comparisons of the in situ Vp/Vs ratios and seismicity characteristics for the Parkfield segment of the San Andreas fault in northern California and the San Jacinto Fault Zone and its adjacent regions in southern California. Our results show that the high-resolution in situ Vp/Vs ratios are much more complex than the tomographic Vp/Vs models. They show similar variation patterns to those in the tomographic Vp models, indicating that Vp/Vs ratios are controlled by material properties but are also strongly influenced by fluid contents. In Parkfield, we observe velocity contrasts between the creeping and locked sections. In southern California, we see small-scale anomalous Vp/Vs variation patterns, especially where fault segments intersect, terminate and change orientations. In addition, our investigation confirms that the seismicity in Parkfield is more repeatable than in southern California. However, the earthquakes in the southernmost portion of the San Andreas fault, the trifurcation area of the San Jacinto Fault Zone and the Imperial fault are as much likely falling into clusters as those in Parkfield. The correlation of highly similar events with anomalous in situ Vp/Vs ratios supports the important role of fluids in the occurrence of repeating earthquakes. The high-resolution Vp/Vs ratio estimation method and the corresponding results are helpful for revealing roles of fluids in driving earthquake, fault interaction and stress distribution in fault zones.

Puerto Rico is a highly seismically active island, where several damaging historical earthquakes have occurred and frequent small events persist. It situates at the boundary between the Caribbean and North American plates, featuring a complex fault system. Here, we investigate the seismotectonic crustal structure of the island by interpreting the 3D compressional-wave velocity VP and compressional- to shear-wave velocity ratio VP/VS models and by analyzing the distribution of the relocated earthquakes. The 3D velocity models are obtained by applying the simul2000 tomographic inversion algorithm based on the phase arrivals recorded by the Puerto Rico seismic network. We find high-VP and low-VP/VS anomalies in the eastern and central province between the Great Northern Puerto Rico fault zone and the Great Southern Puerto Rico fault zone, correlating with the Utuado pluton. Further, there are low-VP anomalies beneath both the Great Southern Puerto Rico fault zone and the South Lajas fault, indicating northerly dipping structures from the southwest to the northwest of the island. We relocate 19,095 earthquakes from May 2017 to April 2021 using the new 3D velocity model and waveform cross-correlation data. The relocated seismicity shows trends along the Investigator fault, the Ponce faults, the Guayanilla rift, and the Punta Montalva fault. The majority of the 2019–2021 Southwestern Puerto Rico earthquakes are associated with the Punta Montalva fault. Earthquakes forming 17° northward-dipping structures at various depths possibly manifest continuation of the Muertos trough, along which the Caribbean plate is being subducted beneath the Puerto Rico microplate. Our results show complex fault geometries of a diffuse fault network, suggesting possible subduction process accommodated by faults within a low-velocity zone.

Background T cells expressing a chimeric antigen receptor (CAR) engineered to target CD19 can treat leukemia effectively but also increase the risk of complications such as cytokine release syndrome (CRS) and CAR T cell related encephalopathy (CRES) driven by interleukin-6 (IL-6). Here, we investigated whether IL-6 knockdown in CART-19 cells can reduce IL-6 secretion from monocytes, which may reduce the risk of adverse events. Methods Supernatants from cocultures of regular CART-19 cells and B lymphoma cells were added to monocytes in vitro, and the IL-6 levels in monocyte supernatants were measured 24 h later. IL-6 expression was knocked down in regular CART-19 cells by adding a short hairpin RNA (shRNA) (termed ssCART-19) expression cassette specific for IL-6 to the conventional CAR vector. Transduction efficiency and cell proliferation were measured by flow cytometry, and cytotoxicity was measured by evaluating the release of lactate dehydrogenase into the medium. Gene expression was assessed by qRT-PCR and RNA sequencing. A xenograft leukemia mouse model was established by injecting NOD/SCID/γc-/- mice with luciferase-expressing B lymphoma cells, and then the animals were treated with regular CART-19 cells or ssCART-19. Tumor growth was assessed by bioluminescence imaging. Results Both recombinant IL-6 and CART-19 derived IL-6 significantly triggered IL-6 release by monocytes. IL-6 knockdown in ssCART-19 cells dramatically reduced IL-6 release from monocytes in vitro stduy. In vivo study further demonstrated that the mice bearing Raji cells treated with ssCART-19 cells showed significant lower IL-6 levels in serum than those treated with regular CART-19 cells, but comparable anti-tumor efficacy between the animal groups. Conclusion CAR T-derived IL-6 is one of the most important initiators to amplify release of IL-6 from monocytes that further drive sCRS development. IL-6 knockdown in ssCART-19 cells by shRNA technology provide a promising strategy to improve the safety of CAR T cell therapy.

I present a high-precision earthquake relocation catalog and first-motion focal mechanisms before and during the 2019 Ridgecrest earthquake sequence in eastern California. I obtain phase arrivals, first-motion polarities, and waveform data from the Southern California Earthquake Data Center for more than 24,000 earthquakes with the magnitudes varying between −0.7 and 7.1 from 1 January to 31 July 2019. I first relocate all the earthquakes using phase arrivals through a previously developed 3D seismic-velocity model and then improve relative location accuracies using differential times from waveform cross correlation. The majority of the relocated seismicity is distributed above 12 km depth. The seismicity migration along the northwest–southeast direction can be clearly seen with an aseismic zone near the Coso volcanic field. Focal mechanisms are solved for all the relocated events based on the first-motion polarity data with dominant strike-slip fault solutions. The Mw 6.4 and 7.1 earthquakes are positioned at 12.45 and 4.16 km depths after the 3D relocation, respectively, with strike-slip focal solutions. These results can help our understanding of the 2019 Ridgecrest earthquake sequence and can be used in other seismological and geophysical studies.

Cephalopods can display variable body color/patterns upon environmental stimulation via bioelectricity-controlled muscle contraction/expansion of skin chromatophores. However, it remains challenging to produce artificial display analogs that exhibit reversible and rapid switching between multiple expected luminescent patterns, although such systems are very appealing for many practical uses (e.g., data encryption). Inspired by the bioelectromechanical display tactic of cephalopods, in this work, a conceptually new photomechanically modulated fluorescent system that enables on-demand display of fluorescent patterns via a cascading stimulation-mechanical movement-optical output conduction mechanism is presented. Specifically, this biomimetic system comprises a customizable hollow display panel and a bottom-tethered photothermally responsive fluorescent actuator. Under NIR light, the photomechanically bending movements of the fluorescent actuator will immediately cover the hollow window of the display panel and synchronously manifest as the display of fluorescent patterns. Owing to its desirable time- and light-power-dependent actuating behaviors, diverse fluorescent patterns/information can be dynamically and reversibly displayed by facilely controlling this single remote NIR signal. This bioinspired strategy is universal and promising for fabricating on-demand fluorescent display platforms that combine a wide choice of fluorophores, remote control with high spatial/temporal precision, and especially single-input multiple-output features.

The NASA/NOAA Visible Infrared Imaging Radiometer Suite (VIIRS) is a key instrument in the JPSS missions (SNPP, JPSS-1-4). Being part of the calibration and validation process, JPSS-3 VIIRS prelaunch geometric performance assessment focuses on the sensor’s spatial response, band-to-band co-registration(BBR), and pointing knowledge. In general, JPSS-3 VIIRS’ prelaunch geometric performance is very good, and consistent with SNPP and JPSS-1-2 VIIRS sensors. This paper highlights some specific key findings from the JPSS-3 VIIRS’ prelaunch tests. We firs t s how that with timing adjustments, JPSS-3 VIIRS scan BBR error between VisNIR and S/M/LWIR bands has been reduced from 0.12/0.03 M sampling intervals to 0.005/0.002 M sampling intervals, respectively. Focal Plane Assembly (FPA) rotations have beenchangedfrom0.1 degree to 0.04 degree in VisVIR, from 0.18 degree to 0.09 degree in S/MWIR, and 0.16 degree to 0.08 degree in LWIR. Another finding from the pre launch test is that JPSS-3 VIIRS has relatively large band-to-band co-registration errors between VisNIR and S/M/LWIR bands in the track direction. This BBR mis - registration increases when aft‐optics assembly (AOA) temperature decreases. The BBRmis-registration is about 0.10 M sampling intervals between VisNIR and S/MWIR bands, and 0.08 M sampling intervals between Vis NIR and LW IR bands. By comparison, the track BBR offset in JPSS-2 is less than 0.02 M sampling intervals between VisNIR and S/M/LWIR bands. We also notice that the unsymmetrical Day Night Band (DNB) scan-direction Line Spread Function (LSF) of JPSS-2 VIIRS at different gain stages and aggregation modes have been corrected in J3 VIIRS.

The Control Point Matching(CPM) program and a set of over 1200 globally distributed ground control points (GCPs ) have been successfully used to develop more than 20 years of MODIS geolocation products. In this research, we refresh current GCP library with more than 2500 new GCPs using the latest Landsat 8 Collection 2 images. The refreshed GCPs are distributedfrom56 S to 80 N latitude, with more than 2000 shoreline and 500 inland GCP chips. The size of these GCPs are extended from 800*800 to 1400*1400 Landsat pixels and the CPM program correspondingly increases the searching distance from0.8 pixels to 2.5 pixels, which also extends the geolocation error measurement from+/-45 to the edge of scan at +/-55 degree in scan angle. This will allow the algorithm to catch geolocation errors that are larger than one MODIS pixel. The geolocation errors measured with the refreshed GCP library are comparable to the previous results, yet with 2-3 more times of matched GCPs. The daytime Aqua ascending orbits and Terra descending orbits enable us to identify a few GCP outliers which might be due to the quality of the original Landsat images. Most importantly, the refreshed GCP library will include images from both Landsat band 4 to match with VII RS I1, and Landsat band 6 to match with VIIRS I3. This will allow us to measure and correct on orbit band-to-band registration at both track and scan directions, which will help understanding and improving future JPSS mission’s prelaunch geometric performance.

A series of conjugate strike‐slip faults is the most prominent geologic feature in central Tibet and is considered to accommodate east‐west extension and coeval north‐south contraction. The development mechanism of the conjugate strike‐slip fault system is under debate because of unclear crustal physical properties and compositional variations. P and S wave arrivals from 414 local earthquakes recorded by the temporary Seismic Array Integrated Detection for a Window of Indian Continental Head array and the permanent China National Seismic Network were used for the velocity tomography, with additional P and S wave arrivals from 12 shots of the International Deep Profiling of Tibet and the Himalaya III reflection/refraction profile. The local earthquakes were simultaneously relocated with the updated velocity models. We also inverted for a three‐dimensional upper crustal Qp model with the same earthquake data set. The Vp structure near the surface shows that low‐Vp anomalies generally correspond to sedimentary basins and high‐Vp anomalies are related to exhumed metamorphic blocks in the study area. Relatively low Vp/Vs ratios in the upper crust indicate widely distributed quartz‐rich rocks. The low‐Vp zone from 0‐ to 10‐km depth (resolving depth limit) is spatially correlated with the Bangong‐Nujiang suture, possibly reflecting the compositional difference along the ophiolitic mélange belt accompanied by twin volcanic arcs from a double‐sided subduction. This interpretation is supported by relatively heterogeneous Qp values. This low‐velocity zone also implies relatively uniform stress and continuous deformation in the upper crust of central Tibet. The relatively weak materials in at least the upper crust would result in strain concentration and help the development of the conjugate strike‐slip fault system along the Bangong‐Nujiang suture.

The widely utilization of renewable energy with low output voltage makes the high voltage ratio boosting converter more popular. This article introduces a non-isolated low input ripple high step-up extendable hybrid DC-DC converter. The proposed converter is based on a two-phase interleaved BOOST converter and switch-capacitor (SC) boost circuit. One of the BOOST channels charges the capacitors in the SC circuit, and the other BOOST channel is connected in series with the capacitors to supply power to the load. Benefiting from this structure, the converter achieves high voltage gain, reduced semiconductor voltage stress, and low input current ripple. Moreover, the converter can be extended by increasing the number of switch-capacitor boost units or the parallel BOOST channels to perform better in voltage gain, input current ripple, and power density. The principle of operation, theoretical analysis, expansion scheme, and comparison with similar topologies are introduced in detail. Finally, a 100W prototype is implemented to verify the validity of the theoretical analysis.

Microplastic pollution has become a major global problem demanding prompt solution. So far, most research has focused on marine environment, but there is a lack of information about microplastic distribution, and persistence uptake in coastal soil environment. In this study, the Huangshui River Basin in Laizhou Bay and Dagu River Basin in Jiaozhou Bay of Shandong Province of China was taken as the research area. A total of 3,352 microplastic items were collected from 12 samples from the four sites in this study. The results showed that local soil was already affected by microplastics, of which 92.9% were particles, 6.1% were fibers, and only 1% were films. The existence of film PE indicated that the microplastic pollution in soil probably came from the plastic film. The degree of pollution was correlated with the size, and the size of microplastics was negatively correlated with abundance. Only a few labelled fibers were detected in groundwater samples, which may come from the external environment. This study contributes to a deeper understanding of environmental microplastic pollution in the coastal region.

We have developed an approach for the measurement of the effective focal length (EFL) and band-to-band registration (BBR) of selected spectral bands of satellite-borne whiskbroom imaging sensors from on-orbit data. Our approach is based on simulating the coarser spatial resolution whiskbroom sensor data with finer spatial resolution Landsat 7 Enhanced Thematic Mapper Plus or Landsat 8 Operational Land Imager data using the geolocation (Earth location) information from each sensor and computing the correlation between the simulated and original data. For each scan of a selected spectral band of the whiskbroom dataset, various subsets of the data are examined to find the subset with the highest spatial correlation between the original and simulated data using the nominal geolocation information. Then, for this best subset, the focal length value and the spatial shift are varied to find the values that produce the highest spatial correlation between the original and simulated data. This best focal length value is taken to be the measured instrument EFL, and the best spatial shift is taken to be the registration of the whiskbroom data relative to the Landsat data, from which the BBR is inferred. Best results are obtained with cloud-free subsets with contrasting land features. This measurement is repeated over other scans with cloud-free subsets. We demonstrate our approach with on-orbit data from the Aqua and Terra MODIS instruments and SNPP and J1 VIIRS instruments.

Additional file 1: Figure S1. CD19 expression in Raji and K562-CD19-LUC cells and CD14 expression in monocytes. A CD19 expression on Raji cells used for the mouse xenograft model and in vitro cytotoxicity assay. B CD14 expression in monocytes, as detected by flow cytometry.

Additional file 3: Figure S3. Effect of IL-6 knockdown on ssCART-19 cell differentiation and gene expression. A Differentiation of ssCART-19 cells and regular CART-19 cells, as detected by flow cytometry, Tscm (stem central memory T cells), Tcm (central memory T cells), Tem (effector memory T cells), Teff (effector T cells). B Top differentially expressed genes in ssCART-19 and regular CART-19 cells after coculture with Raji cells, as analyzed by RNA sequencing. C Gene ontology enrichment analysis of the RNA sequencing data showing the top 30 enriched functions.