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3 results on '"Guohui Xiong"'

1. Trend Analysis of Life Expectancy and Disease Spectrum in Residents of Jing'an District in Shanghai, 2016-2021

Author

CHU Xiaoting, YANG Xiaoming, WAN Qiuping, ZHANG Guohui, XIONG Jianjing, FANG Jialie

Subjects
life expectancy, decomposition of life expectancy, mortality, neoplasms, wounds and injuries, poisoning, tendency, shanghai, Medicine
Abstract

Background As socioeconomic status and population health develop, death patterns and disease spectrum have changed. The impact of diseases on life expectancy have changed as well. Objective To analyze the change in life expectancy and disease spectrum in residents of Jing'an District in Shanghai from 2016 to 2021. Methods Population data and mortality data of permanent residents in Jing'an District of Shanghai from 2016 to 2021 were collected from the Public Security Bureau of Jing'an District, and the Jing'an District Mortality Surveillance System. The ICD-10 was used to categorize the underlying causes of death. The Abridged Life Tables and Arriaga's decomposition method were used to analyze the impacts of age groups and causes of death on life expectancy. Results The life expectancy of these residents from 2016 to 2021 ranged from 83.68 to 84.40 years, which increased by 0.72 years in 2021 compared with that of 2016. The life expectancy of male residents was 81.47 to 82.15 years, demonstrating an increase of 0.68 years during the period. The life expectancy was 85.95 to 86.74 years for female residents, showing an increase of 0.79 years during the period. The decrease of mortality rate in 65 to 84 age group contributed 83.29% to the increase of the life expectancy (0.60 years) , while the decrease of mortality rate in 15 to 44 age group contributed -17.18% to the increase of the life expectancy (-0.12 years) . The largest contribution to the increase of life expectancy was the mortality reduction in cancer, followed by that in respiratory disease, which contributed 56.20% and 53.55%, respectively. The largest contribution to the decrease of life expectancy was increased mortality due to injuries and poisoning, followed by that due to endocrine, nutritional and metabolic diseases, which contributed -35.69% and -17.25%, respectively. Conclusion The life expectancy of residents in Jing'an District from 2016 to 2021 was 83.68 to 84.40 years, seeing an increase of 0.72 years. The increase of life expectancy was mainly attributed to the decrease of mortality in 65 to 84 age group and the decrease of mortality due to cancer. However, the increase of mortality due to injuries and poisoning had negative contribution.

Published
2022
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2. Aberrant activation of the Hedgehog signaling pathway in granulosa cells from patients with polycystic ovary syndrome

Author

ZiYu Zhang, Jun Tan, Lei Wan, Shudi Wang, Ouping Huang, Qiongfang Wu, Guohui Xiong, and You Li

Subjects
Adult, endocrine system, endocrine system diseases, hedgehog, Ihh, Bioengineering, Apoptosis, Biology, Applied Microbiology and Biotechnology, Patched-2 Receptor, Young Adult, Text mining, PCOS, Cluster Analysis, Humans, Hedgehog Proteins, RNA, Messenger, Cells, Cultured, Granulosa Cells, Base Sequence, business.industry, Tumor Necrosis Factor-alpha, Gene Expression Profiling, nutritional and metabolic diseases, General Medicine, Ptch2, Polycystic ovary, Hedgehog signaling pathway, female genital diseases and pregnancy complications, Treatment Outcome, Gene Expression Regulation, Case-Control Studies, Cancer research, Female, business, TP248.13-248.65, Biotechnology, Research Article, Gli, Polycystic Ovary Syndrome, Signal Transduction
Abstract

Objective The molecular mechanism that triggers polycystic ovary syndrome (PCOS) is mysterious. Abnormal development of ovarian granulosa cells(GCs) is one of the causes of PCOSMethods The study was carried out by using RNA-seq to detect the different gene expression levels in ovarian GCs between 3 patients with PCOS and 4 normal controls. To further verify the above results, GCs from 22 patients with PCOS and 21 controls with normal ovulation were collected to perform the RT-PCR analysisResults The results found Hedgehog signaling pathway(Hh) members, Ihh and Ptch2 were abnormally highly expressed in the PT. The qPCR results also indicated that the expression levels of other Hh signaling pathway downstream members, Ptch1, Gli1, and Gli2 in the PCOS group (PT) were significantly higher than those in the control group (NT). Besides, the expression of TNF-α mRNA in PCOS patients was higher than that in the control group. Finally, the Hh signaling pathway inhibitor, cyclopamine, can decrease the apoptosis of PCOS ovarian granulosa cellsConclusions These results suggest that abnormally activated Hh signaling pathway, especially Ihh signal, may have a profound influence on PCOS.

Published
2021

3. Operation strategy and performance investigation of a high-efficiency multifunctional two-stage vapor compression heat pump air conditioning system for electric vehicles in severe cold regions

Author

Wei Sun, Hai Song, Guohui Xiong, Guogeng He, and Qian Ning

Subjects
Exergy, Pressure drop, Materials science, Renewable Energy, Sustainability and the Environment, business.industry, Nuclear engineering, Energy Engineering and Power Technology, Coefficient of performance, law.invention, Refrigerant, law, Air conditioning, Vapor-compression refrigeration, business, Temperature coefficient, Heat pump
Abstract

Cooling and heating are indispensable for electric vehicles (EVs) in severe cold regions due to the hot summer caused by global warming. A multifunctional two-stage vapor compression (MTSC) heat pump air conditioning system (HPAC) with its operation strategies is proposed, which can operate in not only single-stage vapor compression (SSC) cooling and heating mode, but also two-stage vapor compression (TSC) heating mode under ambient temperatures as low as −35 °C. Then a simulation model is developed, and comparative analyses among the MTSC HPACs with different refrigerants, and between MTSC HPACs and SSC HPACs are conducted. The influences of intermediate pressure and pressure drop on performance are discussed. Besides, exergy analysis and second law performance are presented. It is found that the MTSC HPAC attains a 6% to 30% higher coefficient of performance (COP) than the SSC HPAC when the evaporating temperature changes from −10 °C to −20 °C, and 156% to 85% higher energy efficiency than the positive temperature coefficient (PTC) heaters when the evaporating temperature varies from −25 °C to −45 °C. The COP of R290 is slightly higher than that of R410A, R32 and R454C. Furthermore, the main exergy destruction appears in compressors, accounting for 40% to 45%.

Published
2021

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