16 results on '"Guo-Yun Yu"'
Search Results
2. The sclerophyllous Eucalyptus camaldulensis and herbaceous Nicotiana tabacum have different mechanisms to maintain high rates of photosynthesis
- Author
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Wei Huang, You-Gui Tong, Guo-Yun Yu, and Wei-Xian Yang
- Subjects
photorespiration ,mesophyll conductance ,CO2 assimilation ,Sclerophyllous ,Alternative electron flow ,Plant culture ,SB1-1110 - Abstract
It is believed that high levels of mesophyll conductance (gm) largely contribute to the high rates of photosynthesis in herbaceous C3 plants. However, some sclerophyllous C3 plants that display low levels of gm have high rates of photosynthesis, and the underlying mechanisms responsible for high photosynthetic rates in sclerophyllous C3 plants are unclear. In the present study, we examined photosynthetic characteristics in two high-photosynthesis plants (the sclerophyllous Eucalyptus camaldulensis and the herbaceous Nicotiana tabacum) using measurements of gas exchange and chlorophyll fluorescence. Under saturating light intensities, both species had similar rates of CO2 assimilation at 400 μmol mol-1 CO2 (A400). However, E. camaldulensis exhibited significantly lower gm and chloroplast CO2 concentration (Cc) than N. tabacum. A quantitative analysis revealed that, in E. camaldulensis, the gm limitation was the most constraining factor for photosynthesis. By comparison, in N. tabacum, the biochemical limitation was the strongest, followed by gm and gs limitations. In conjunction with a lower Cc, E. camaldulensis up-regulated the capacities of photorespiratory pathway and alternative electron flow. Furthermore, the rate of alternative electron flow was positively correlated with the rates of photorespiration and ATP supply from other flexible mechanisms, suggesting the important roles of photorespiratory pathway and alternative electron flow in sustaining high rate of photosynthesis in E. camaldulensis. These results highlight the different mechanisms used to maintain high rates of photosynthesis in the sclerophyllous E. camaldulensis and the herbaceous N. tabacum.
- Published
- 2016
- Full Text
- View/download PDF
3. Standards for Sequencing Viral Genomes in the Era of High-Throughput Sequencing
- Author
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Jason T. Ladner, Brett Beitzel, Patrick S. G. Chain, Matthew G. Davenport, Eric Donaldson, Matthew Frieman, Jeffrey Kugelman, Jens H. Kuhn, Jules O’Rear, Pardis C. Sabeti, David E. Wentworth, Michael R. Wiley, Guo-Yun Yu, Shanmuga Sozhamannan, Christopher Bradburne, and Gustavo Palacios
- Subjects
Microbiology ,QR1-502 - Abstract
ABSTRACT Thanks to high-throughput sequencing technologies, genome sequencing has become a common component in nearly all aspects of viral research; thus, we are experiencing an explosion in both the number of available genome sequences and the number of institutions producing such data. However, there are currently no common standards used to convey the quality, and therefore utility, of these various genome sequences. Here, we propose five “standard” categories that encompass all stages of viral genome finishing, and we define them using simple criteria that are agnostic to the technology used for sequencing. We also provide genome finishing recommendations for various downstream applications, keeping in mind the cost-benefit trade-offs associated with different levels of finishing. Our goal is to define a common vocabulary that will allow comparison of genome quality across different research groups, sequencing platforms, and assembly techniques.
- Published
- 2014
- Full Text
- View/download PDF
4. Production data evaluation analysis model: a case study of broaching machine
- Author
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Yu, Chun-Min, primary, Chen, Kuen-Suan, additional, and Guo, Yun-Yu, additional
- Published
- 2021
- Full Text
- View/download PDF
5. Photosynthetic characteristics explain the high growth rate for Eucalyptus camaldulensis: Implications for breeding strategy
- Author
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Ying-Jie Yang, Shi-Bao Zhang, You-Gui Tong, Guo-Yun Yu, and Wei Huang
- Subjects
0106 biological sciences ,0301 basic medicine ,Stomatal conductance ,Subtropics ,Biology ,Photosynthesis ,01 natural sciences ,03 medical and health sciences ,030104 developmental biology ,Eucalyptus camaldulensis ,Agronomy ,Growth rate ,Water-use efficiency ,Agronomy and Crop Science ,010606 plant biology & botany - Abstract
Eucalypt wood is a valuable raw material for pulping worldwide. Because of its high growth rate, Eucalyptus camaldulensis has been introduced for plantation production in many tropical and subtropical areas in China. However, photosynthetic mechanisms underlying the rapid growth rate of E. camaldulensis are not well known. Furthermore, little is known about the relative photosynthetic limitations that complicate breeding strategies for this species. In the present study, we examined the photosynthetic characteristics for leaves of E. camaldulensis and observed stomata on both adaxial and abaxial surfaces, with their density being higher on the latter. Regardless of which surface was exposed to sunlight, the actual whole-leaf photosynthesis of E. camaldulensis reached 42.00 μmol CO2 m−2 s−1, which is much higher than that reported for other C3 plants. Although both surfaces showed high photosynthetic rates, photosynthesis and intrinsic water-use efficiency were always greater on the abaxial surface, mainly because of differences in mesophyll conductance (gm). Analysis of quantitative limitations revealed that gm was the most constraining factor for photosynthesis while stomatal conductance was much less important. Taken together, our results imply that gm is a potential target for simultaneous improvement of photosynthesis and photosynthetic water-use efficiency in E. camaldulensis, and we propose that increased gm is an important trait for breeding of that species.
- Published
- 2018
6. M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity
- Author
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Leah F. Rosin, Guo-Yun Yu, Elissa P. Lei, Yang Chen, Chen-Yu Liu, Indira Bag, and Shue Chen
- Subjects
Male ,Transcriptional Activation ,Science ,Genome, Insect ,General Physics and Astronomy ,Biology ,Insulator (genetics) ,Genome ,General Biochemistry, Genetics and Molecular Biology ,Article ,Cell Line ,Animals, Genetically Modified ,03 medical and health sciences ,0302 clinical medicine ,Transcription (biology) ,Animals ,Drosophila Proteins ,RNA-Seq ,Promoter Regions, Genetic ,Transcription factor ,030304 developmental biology ,Cell Nucleus ,0303 health sciences ,Nuclear organization ,Multidisciplinary ,Chromatin binding ,Nuclear Proteins ,Promoter ,General Chemistry ,Chromatin ,Cell biology ,Repressor Proteins ,Drosophila melanogaster ,Gene Knockdown Techniques ,Chromatin Immunoprecipitation Sequencing ,Insulator Elements ,Microtubule-Associated Proteins ,030217 neurology & neurosurgery ,Nuclear localization sequence ,Transcription Factors - Abstract
Genome organization is driven by forces affecting transcriptional state, but the relationship between transcription and genome architecture remains unclear. Here, we identified the Drosophila transcription factor Motif 1 Binding Protein (M1BP) in physical association with the gypsy chromatin insulator core complex, including the universal insulator protein CP190. M1BP is required for enhancer-blocking and barrier activities of the gypsy insulator as well as its proper nuclear localization. Genome-wide, M1BP specifically colocalizes with CP190 at Motif 1-containing promoters, which are enriched at topologically associating domain (TAD) borders. M1BP facilitates CP190 chromatin binding at many shared sites and vice versa. Both factors promote Motif 1-dependent gene expression and transcription near TAD borders genome-wide. Finally, loss of M1BP reduces chromatin accessibility and increases both inter- and intra-TAD local genome compaction. Our results reveal physical and functional interaction between CP190 and M1BP to activate transcription at TAD borders and mediate chromatin insulator-dependent genome organization., Transcriptional state plays a role in genome organization, however factors that link these processes are not well known. Here, the authors show Drosophila transcription factor Motif 1-binding protein (M1BP) interacts with the insulator protein CP190 to promote insulator function and activate Motif 1-dependent transcription at topologically associating domain (TAD) borders.
- Published
- 2020
7. The Sclerophyllous
- Author
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Wei, Huang, You-Gui, Tong, Guo-Yun, Yu, and Wei-Xian, Yang
- Subjects
photorespiration ,mesophyll conductance ,Plant Science ,CO2 assimilation ,sclerophyllous ,Original Research ,alternative electron flow - Abstract
It is believed that high levels of mesophyll conductance (gm) largely contribute to the high rates of photosynthesis in herbaceous C3 plants. However, some sclerophyllous C3 plants that display low levels of gm have high rates of photosynthesis, and the underlying mechanisms responsible for high photosynthetic rates in sclerophyllous C3 plants are unclear. In the present study, we examined photosynthetic characteristics in two high-photosynthesis plants (the sclerophyllous Eucalyptus camaldulensis and the herbaceous Nicotiana tabacum) using measurements of gas exchange and chlorophyll fluorescence. Under saturating light intensities, both species had similar rates of CO2 assimilation at 400 μmol mol−1 CO2 (A400). However, E. camaldulensis exhibited significantly lower gm and chloroplast CO2 concentration (Cc) than N. tabacum. A quantitative analysis revealed that, in E. camaldulensis, the gm limitation was the most constraining factor for photosynthesis. By comparison, in N. tabacum, the biochemical limitation was the strongest, followed by gm and gs limitations. In conjunction with a lower Cc, E. camaldulensis up-regulated the capacities of photorespiratory pathway and alternative electron flow. Furthermore, the rate of alternative electron flow was positively correlated with the rates of photorespiration and ATP supply from other flexible mechanisms, suggesting the important roles of photorespiratory pathway, and alternative electron flow in sustaining high rate of photosynthesis in E. camaldulensis. These results highlight the different mechanisms used to maintain high rates of photosynthesis in the sclerophyllous E. camaldulensis and the herbaceous N. tabacum.
- Published
- 2016
8. Cynomolgus macaque (Macaca fascicularis) immunoglobulin heavy chain locus description
- Author
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Matthew Hall, Ernst E. Brueggemann, Gustavo Palacios, Karla Garcia, Suzanne Mate, Marie-Paule Lefranc, Michael D. Ward, Tara Kenny, Guo Yun Yu, and Mariano Sanchez-Lockhart
- Subjects
0301 basic medicine ,Proteomics ,Genes, Immunoglobulin Heavy Chain ,Immunology ,Immunoglobulin Variable Region ,Locus (genetics) ,Biology ,Genome ,DNA sequencing ,03 medical and health sciences ,0302 clinical medicine ,Species Specificity ,Tandem Mass Spectrometry ,Genetics ,Animals ,Humans ,Amino Acid Sequence ,Gene ,Phylogeny ,Base Sequence ,High-Throughput Nucleotide Sequencing ,Molecular Sequence Annotation ,Human genetics ,Macaca fascicularis ,030104 developmental biology ,biology.protein ,IGHD ,Antibody ,IGHV@ ,030217 neurology & neurosurgery ,Chromatography, Liquid - Abstract
Cynomolgus macaques (Macaca fascicularis) have become an important animal model for biomedical research. In particular, it is the animal model of choice for the development of vaccine candidates associated with emerging dangerous pathogens. Despite their increasing importance as animal models, the cynomolgus macaque genome is not fully characterized, hindering molecular studies for this model. More importantly, the lack of knowledge about the immunoglobulin (IG) locus organization directly impacts the analysis of the humoral response in cynomolgus macaques. Recent advances in next generation sequencing (NGS) technologies to analyze IG repertoires open the opportunity to deeply characterize the humoral immune response. However, the IG locus organization for the animal is required to completely dissect IG repertoires. Here, we describe the localization and organization of the rearranging IG heavy (IGH) genes on chromosome 7 of the cynomolgus macaque draft genome. Our annotation comprises 108 functional genes which include 63 variable (IGHV), 38 diversity (IGHD), and 7 joining (IGHJ) genes. For validation, we provide RNA transcript data for most of the IGHV genes and all of the annotated IGHJ genes, as well as proteomic data to validate IGH constant genes. The description and annotation of the rearranging IGH genes for the cynomolgus macaques will significantly facilitate scientific research. This is particularly relevant to dissect the immune response during vaccination or infection with dangerous pathogens such as Ebola, Marburg and other emerging pathogens where non-human primate models play a significant role for countermeasure development.
- Published
- 2016
9. A conserved eEF2 coding variant in SCA26 leads to loss of translational fidelity and increased susceptibility to proteostatic insult
- Author
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Haipeng Zhu, H. Brent Clark, Giovanni Stevanin, Kristina Gervin, Xiaofei Du, Dag E. Undlien, Katherine E. Hekman, Kevin P. White, Guo Yun Yu, Stefan M. Pulst, April Peterson, Christopher D. Brown, Thomas D. Bird, and Christopher M. Gomez
- Subjects
Elongation Factor 2 Kinase ,Models, Molecular ,Saccharomyces cerevisiae Proteins ,Genotype ,Protein Conformation ,Blotting, Western ,Molecular Sequence Data ,Locus (genetics) ,Biology ,Transfection ,EEF2 ,Ribosomal frameshift ,Conserved sequence ,Purkinje Cells ,Yeasts ,Genetics ,medicine ,Humans ,Spinocerebellar Ataxias ,Genetic Predisposition to Disease ,Amino Acid Sequence ,Molecular Biology ,Conserved Sequence ,Genetics (clinical) ,Sequence Analysis, RNA ,Genetic heterogeneity ,Clinical Coding ,Articles ,General Medicine ,medicine.disease ,Elongation factor ,HEK293 Cells ,Phenotype ,Amino Acid Substitution ,Genetic Loci ,Mutation ,Unfolded protein response ,Spinocerebellar ataxia ,Plasmids - Abstract
The autosomal dominant spinocerebellar ataxias (SCAs) are a genetically heterogeneous group of disorders exhibiting cerebellar atrophy and Purkinje cell degeneration whose subtypes arise from 31 distinct genetic loci. Our group previously published the locus for SCA26 on chromosome 19p13.3. In this study, we performed targeted deep sequencing of the critical interval in order to identify candidate causative variants in individuals from the SCA26 family. We identified a single variant that co-segregates with the disease phenotype that produces a single amino acid substitution in eukaryotic elongation factor 2. This substitution, P596H, sits in a domain critical for maintaining reading frame during translation. The yeast equivalent, P580H EF2, demonstrated impaired translocation, detected as an increased rate of -1 programmed ribosomal frameshift read-through in a dual-luciferase assay for observing translational recoding. This substitution also results in a greater susceptibility to proteostatic disruption, as evidenced by a more robust activation of a reporter gene driven by unfolded protein response activation upon challenge with dithiothreitol or heat shock in our yeast model system. Our results present a compelling candidate mutation and mechanism for the pathogenesis of SCA26 and further support the role of proteostatic disruption in neurodegenerative diseases.
- Published
- 2012
10. MicrobiomeGWAS: a tool for identifying host genetic variants associated with microbiome composition
- Author
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Jianxin Shi, Abnet Cc, Xing Hua, Guo-Yun Yu, Long-Sheng Song, Maria Teresa Landi, and James J. Goedert
- Subjects
Genetics ,UniFrac ,Distance matrix ,Human microbiome ,Kurtosis ,Single-nucleotide polymorphism ,Microbiome ,Computational biology ,Biology ,Distance matrices in phylogeny ,Genetic association - Abstract
The microbiome is the collection of all microbial genes and can be investigated by sequencing highly variable regions of 16S ribosomal RNA (rRNA) genes. Evidence suggests that environmental factors and host genetics may interact to impact human microbiome composition. Identifying host genetic variants associated with human microbiome composition not only provides clues for characterizing microbiome variation but also helps to elucidate biological mechanisms of genetic associations, prioritize genetic variants, and improve genetic risk prediction. Since a microbiota functions as a community, it is best characterized by beta diversity, that is, a pairwise distance matrix. We develop a statistical framework and a computationally efficient software package, microbiomeGWAS, for identifying host genetic variants associated with microbiome beta diversity with or without interacting with an environmental factor. We show that score statistics have positive skewness and kurtosis due to the dependent nature of the pairwise data, which makes P-value approximations based on asymptotic distributions unacceptably liberal. By correcting for skewness and kurtosis, we develop accurate P-value approximations, whose accuracy was verified by extensive simulations. We exemplify our methods by analyzing a set of 147 genotyped subjects with 16S rRNA microbiome profiles from non-malignant lung tissues. Correcting for skewness and kurtosis eliminated the dramatic deviation in the quantile-quantile plots. We provided preliminary evidence that six established lung cancer risk SNPs were collectively associated with microbiome composition for both unweighted (P=0.0032) and weighted (P=0.011) UniFrac distance matrices. In summary, our methods will facilitate analyzing large-scale genome-wide association studies of the human microbiome.
- Published
- 2015
- Full Text
- View/download PDF
11. Complete Coding Sequences of Eastern Equine Encephalitis Virus and Venezuelan Equine Encephalitis Virus Strains Isolated from Human Cases
- Author
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Elaine M. Morazzani, Brett Beitzel, Pamela J. Glass, Lori T. Eccleston, Gustavo Palacios, Jeffrey R. Kugelman, Jason T. Ladner, Michael R. Wiley, and Guo Yun Yu
- Subjects
Eastern equine encephalitis virus ,viruses ,Strain (biology) ,Viruses ,Venezuelan equine encephalitis virus ,Veterinary virology ,Genetics ,medicine ,Biology ,medicine.disease_cause ,Molecular Biology ,Genome ,Virology - Abstract
We obtained the complete coding genome of an eastern equine encephalitis virus (EEEV) strain, EEEV V105-00210, and the complete genome of a Venezuelan equine encephalitis virus (VEEV) strain, VEEV INH-9813. They were obtained from human cases and are proposed as reference challenge strains for vaccine and therapeutic development in animal models.
- Published
- 2015
12. Spinocerebellar ataxia type 26 maps to chromosome 19p13.3 adjacent to SCA6
- Author
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Matthew J. Roller, Ting Dong Xie, Michael J. Howell, Christopher M. Gomez, and Guo Yun Yu
- Subjects
Adult ,Male ,Cerebellum ,Ataxia ,Genetic Linkage ,DNA Mutational Analysis ,Locus (genetics) ,Biology ,Genetic linkage ,medicine ,Humans ,Spinocerebellar Ataxias ,Aged ,Family Health ,Genetics ,Cerebellar ataxia ,Genetic heterogeneity ,Chromosome Mapping ,Chromosome ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Pedigree ,medicine.anatomical_structure ,Neurology ,Spinocerebellar ataxia ,Female ,Calcium Channels ,Neurology (clinical) ,medicine.symptom ,Chromosomes, Human, Pair 19 - Abstract
The dominantly inherited spinocerebellar ataxias (SCA) are a clinically and genetically heterogeneous group of neurodegenerative disorders characterized by progressive gait ataxia, upper limb incoordination, and dysarthria. We studied a six-generation kindred of Norwegian ancestry with pure cerebellar ataxia inherited in an autosomal dominant pattern. All affected family members had a slowly progressive cerebellar ataxia, with an age of onset range from 26 to 60 years. Brain magnetic resonance imaging study of 11 affected patients showed that atrophy was confined to the cerebellum. After excluding all the known SCAs using linkage analysis or direct mutation screen, we conducted a genomewide genetic linkage scan. With the aid of a novel linkage analysis strategy, we found linkage between the disease locus and marker D19S591 and D19S1034. Subsequent genetic and clinical analysis identified a critical region of 15.55cM interval on chromosome 19p13.3, flanked by markers D19S886 and D19S894, and have established a new genetic locus designated SCA26. The SCA26 locus is adjacent to the genes for Cayman ataxia and SCA6. The region consists of 3.3 million base pairs (Mb) of DNA sequences with approximately 100 known and predicted genes. Identification of the responsible gene for SCA26 ataxia will provide further insight into mechanisms of neurodegeneration.
- Published
- 2005
13. Standards for Sequencing Viral Genomes in the Era of High-Throughput Sequencing
- Author
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Jules O'Rear, David E. Wentworth, Patrick S. G. Chain, Brett Beitzel, Matthew G Davenport, Christopher E. Bradburne, Shanmuga Sozhamannan, Eric F. Donaldson, Pardis C. Sabeti, Michael R. Wiley, Matthew B. Frieman, Jens H. Kuhn, Jeffrey R. Kugelman, Gustavo Palacios, Jason T. Ladner, and Guo-Yun Yu
- Subjects
Genetics ,Vocabulary ,Research groups ,media_common.quotation_subject ,DNA sequencing theory ,Computational biology ,Biology ,Microbiology ,Genome ,QR1-502 ,DNA sequencing ,ComputingMethodologies_PATTERNRECOGNITION ,Viral genomes ,Virology ,Component (UML) ,Quality (business) ,Guest Editorial ,media_common - Abstract
Thanks to high-throughput sequencing technologies, genome sequencing has become a common component in nearly all aspects of viral research; thus, we are experiencing an explosion in both the number of available genome sequences and the number of institutions producing such data. However, there are currently no common standards used to convey the quality, and therefore utility, of these various genome sequences. Here, we propose five “standard” categories that encompass all stages of viral genome finishing, and we define them using simple criteria that are agnostic to the technology used for sequencing. We also provide genome finishing recommendations for various downstream applications, keeping in mind the cost-benefit trade-offs associated with different levels of finishing. Our goal is to define a common vocabulary that will allow comparison of genome quality across different research groups, sequencing platforms, and assembly techniques.
- Published
- 2014
14. Transcriptome reconstruction and annotation of cynomolgus and African green monkey
- Author
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Oliver Elliott, Elyse R. Nagle, Gustavo Palacios, Albert Lee, Guo-Yun Yu, Travis K. Warren, Raul Rabadan, Jeffrey R. Kugelman, and Hossein Khiabanian
- Subjects
FOS: Computer and information sciences ,Bioinformatics ,Annotation ,RNA-Seq ,Genomics ,Computational biology ,Genome browser ,Biology ,Genome ,Transcriptome ,Cynomolgus macaque ,Database ,Chlorocebus aethiops ,Genetics ,Animals ,Comparative Genomic Hybridization ,Sequence Analysis, RNA ,Gene Expression Profiling ,High-Throughput Nucleotide Sequencing ,Molecular Sequence Annotation ,Exons ,African green monkey ,Macaca fascicularis ,FOS: Biological sciences ,African Green Monkey ,DNA microarray ,RNA-seq ,Biotechnology ,Research Article - Abstract
Background Non-human primates (NHPs) and humans share major biological mechanisms, functions, and responses due to their close evolutionary relationship and, as such, provide ideal animal models to study human diseases. RNA expression in NHPs provides specific signatures that are informative of disease mechanisms and therapeutic modes of action. Unlike the human transcriptome, the transcriptomes of major NHP animal models are yet to be comprehensively annotated. Results In this manuscript, employing deep RNA sequencing of seven tissue samples, we characterize the transcriptomes of two commonly used NHP animal models: Cynomolgus macaque (Macaca fascicularis) and African green monkey (Chlorocebus aethiops). We present the Multi-Species Annotation (MSA) pipeline that leverages well-annotated primate species and annotates 99.8% of reconstructed transcripts. We elucidate tissue-specific expression profiles and report 13 experimentally validated novel transcripts in these NHP animal models. Conclusion We report comprehensively annotated transcriptomes of two non-human primates, which we have made publically available on a customized UCSC Genome Browser interface. The MSA pipeline is also freely available. Electronic supplementary material The online version of this article (doi:10.1186/1471-2164-15-846) contains supplementary material, which is available to authorized users.
- Published
- 2014
15. Transcriptome reconstruction and annotation of cynomolgus and African green monkey.
- Author
-
Lee, Albert, Khiabanian, Hossein, Kugelman, Jeffrey, Elliott, Oliver, Nagle, Elyse, Guo-Yun Yu, Warren, Travis, Palacios, Gustavo, and Rabadan, Raul
- Abstract
Background: Non-human primates (NHPs) and humans share major biological mechanisms, functions, and responses due to their close evolutionary relationship and, as such, provide ideal animal models to study human diseases. RNA expression in NHPs provides specific signatures that are informative of disease mechanisms and therapeutic modes of action. Unlike the human transcriptome, the transcriptomes of major NHP animal models are yet to be comprehensively annotated. Results: In this manuscript, employing deep RNA sequencing of seven tissue samples, we characterize the transcriptomes of two commonly used NHP animal models: Cynomolgus macaque (Macaca fascicularis) and African green monkey (Chlorocebus aethiops). We present the Multi-Species Annotation (MSA) pipeline that leverages well-annotated primate species and annotates 99.8% of reconstructed transcripts. We elucidate tissue-specific expression profiles and report 13 experimentally validated novel transcripts in these NHP animal models. Conclusion: We report comprehensively annotated transcriptomes of two non-human primates, which we have made publically available on a customized UCSC Genome Browser interface. The MSA pipeline is also freely available. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
16. Spinocerebellar ataxia type 26 maps to chromosome 19p13.3 adjacent to SCA6.
- Author
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Guo‐Yun Yu, Michael J. Howell, Matthew J. Roller, Ting‐Dong Xie, and Christopher M. Gomez
- Published
- 2005
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