Search

The lipid profiles, including lipid classes, phospholipid (PL) classes, fatty acid (FA) composition, and glycerophospholipid (GP) molecular species, in the two edible parts (edible viscera and musc...

Geometric phases have attracted considerable attention in recent years, due to their capability of arbitrary beam shaping in a most efficient and compact way, while traditional geometric phases are usually limited to handling single-structured beams and lack the capability of parallel manipulation. Here, we propose a digitalized geometric phase enabling parallel optical spin and orbital angular momentum encoding. The concept is demonstrated in inhomogeneous anisotropic media by imprinting a particularly designed binary phase into a space-variant geometric phase. We theoretically analyze its spin–orbit interaction of light and experimentally created higher-order Poincare sphere beam lattices, the order number and symmetry of which can be flexibly manipulated. Special lattices of cylindrical vector beams and orbital angular momentum modes with square and hexagonal symmetry are presented. This work discloses a new insight in programming geometric phases for tailoring the optical field and inspires various ph...

We experimentally demonstrate the use of a periodically poled LiNbO3 (PPLN) crystal to produce an ultra-long sub-diffraction optical needle via second-harmonic generation. When we input a radially polarized fundamental wave from a femtosecond laser, a sub-diffraction beam size of 0.45λSH and an ultra-long depth of focus (DOF) of 55λSH are experimentally realized, where λSH is the second harmonic wavelength. The lateral size of the second harmonic optical needle is reduced by a factor of 2 compared to the case using the fundamental wave. The compact experimental configuration can realize wavelength conversion and wave-front shaping simultaneously in a single PPLN crystal. In addition, the ultra-long DOF is potentially useful in observing thick samples. The unique characteristics of our second harmonic optical needle open the door for practical applications in super-resolution imaging and optical manipulation.

O R IG IN A L P A P ER Abstract The unique electronic and mechanical properties, of graphene make it an ideal material for nanoelectromechanical system (NEMS) applications. Here, a miniature optical fiber current sensor based on a quasistatic graphene NEMS with a graphene membrane covering the hole on a pre-etched fiber tip and two gold electrodes on opposite sides of the tip has been demonstrated. The sensor overcomes the shortcomings of conventional optical fiber current sensors based on thermal effects, such as relatively low sensitivity, long response time, and huge device size; it has simultaneously a high sensitivity of 2.2 × 105 nm/A2, a short response time of 0.25 s and a compact device size of 15 μm, and has found practical application. Using a smaller graphene membrane with better quality can reduce the response time to submillisecond levels with a more precise measurement system. The sensor presented in this paper may pave the way for the practical usage of optical fiber current sensors based on thermal effects.

Optical-quality single-crystal LiB3O5 (LBO) nanowires are synthesized for the first time using a sol–gel method. The LBO nanowires possess diameters ranging from 200 to 800 nm and lengths of up to 200 μm, and exhibit excellent uniformity, smooth surfaces, and good mechanical properties. A typical propagating loss of 0.038 dB/μm at 532 nm is obtained for a 620 nm-diameter nanowire. This is a decrease of one order of magnitude compared with that of a β-BaB2O4 (BBO) nanowire with similar diameter, which makes the LBO nanowire a promising candidate to construct miniaturized nonlinear photonic devices.

We observe the symmetrical dual-valley spectrum in periodically poled lithium niobate (PPLN) with a defect in the middle employing electro-optic effect. When the external electric fields are applied, light satisfying phase-matching condition (λ 0 ) will undergo polarization rotation and then turn back. However, the polarization states of wavelength at λ 0 ±Δλ will be changed at the end of the sample due to phase mismatching. A dual-valley transmission spectrum is thus obtained. Moreover, the depth of the valley could be tailored with different electric fields on the y-surface of the sample.

Lithium niobate (LiNbO3) nonlinear photonic crystals have been widely used in nonlinear wave front modulation for the π-phase difference between the second-harmonic (SH) waves from positive and negative domains. Aided by optimizing algorithms, we can control the diffraction patterns of SH vortex beams by designing nonlinear fork gratings with supercell structures in LiNbO3 crystals. In experiment, we demonstrate that the diffraction energies can be equally distributed in each order or concentrated on certain orders, in agreement with theoretical designs. Potential applications include controllable vortex beam generation, nondestructive parallel vortex detection, and so on.

In this paper, we experimentally demonstrate the second harmonic generation of long-range surface plasmon polaritons via quasi-phase matching in lithium niobate. After depositing a 9/13 nm thick Au film on periodically poled lithium niobate, TiO2 of about 2.3 μm in thickness is evaporated on the sample as a refractive-index-matching material. This dielectric (periodically poled lithium niobate)–metal(Au)–dielectric(TiO2) sandwich structure can support the transmission of long-range surface plasmon polaritons through it. By designing a moderate ferroelectric domain period of periodically poled lithium niobate, the phase mismatch between the fundamental wave and second harmonic wave of the long-range surface plasmon polaritons can be compensated and a second harmonic wave can be generated effectively. This can be used to provide integrated plasmonic devices with attractive applications in quantum and classic information processing.

Potentiation of GABAA receptor-mediated inhibitory neurotransmission contributes to the anesthetic action of thiopental. However, the inhibiting action of general anesthetic on excitatory neurotransmission also purportedly underlies its effects. The aim of the study was to elucidate the role of glutamate receptors (NMDA and AMPA receptors) in thiopental-induced anesthesia. Intracerebroventricular (i.c.v.) NMDA (50 ng) significantly increased the induction time of loss of righting reflex and decreased sleep time induced by intraperitoneal injection (i.p.) of thiopental (50 mg/kg). Furthermore, NMDA at 50 ng i.c.v. increased the 50% effective dose values for thiopental to produce loss of righting reflex and immobility in response to noxious tail clamp by 25% and 21% (p < 0.05), respectively. However, intrathecal (IT) administration of NMDA or both of i.c.v. or IT administration of AMPA did not show such antagonizing effects on thiopental action at subconvulsive dose. Finally, thiopental (25 mg/kg i.p.) inhibited convulsions induced by NMDA (0.4 µg i.c.v.) or bicuculline (0.6 µg i.c.v.). However, i.p. muscimol (1 mg/kg) blocked the convulsions induced by bicuculline, but not those induced by NMDA at 3 mg/kg. Similarly, i.p. MK-801 (0.1 mg/kg) antagonized NMDA-induced convulsions, but not bicuculline-induced convulsions at 0.3 mg/kg. Therefore, we suggest that the effects of the selective GABAA and NMDA receptors on convulsive behavior are special to their sites of action, and that the inhibitory action of thiopental on NMDA receptors is possibly not mediated by secondary effects of its GABAA receptors agonism. These results above indicate the involvement of NMDA receptors in thiopental-induced anesthesia in mice.

In recent years, complex optical fields with spatially inhomogeneous phases, polarizations and optical singularities have drawn many research interests. Many novel effects have been predicted and demonstrated for light beams with these unconventional states in both linear and nonlinear optics regimes. Although local optical phase could be controlled directly or through hologram structures in isotropic materials such as glasses, optical anisotropy is still required for manipulating polarization states and wavelengths. The anisotropy could be either intrinsic such as in crystals/liquid crystals (LCs) or the induced birefringence from dielectric or metallic structures. In this talk, we will briefly review some of our attempts in tailoring complex optical fields via anisotropic microstructures. We developed a micro-photo-patterning system that could generate complex micro-images then further guides the arbitrary local LC directors. Due to the electro-optically (EO) tunable anisotropy of LC, various reconfigurable complex optical fields such as optical vortices (OVs), multiplexed OVs, OV array, Airy beams and vector beams are obtained. Different LC modes such as homogeneous alignment nematic, hybrid alignment nematic and even blue phase LCs are adopted to optimize the static and dynamic beam characteristics depending on application circumstances. We are also trying to extend our approaches to new wavelength bands, such as mid-infrared and even THz ranges. Some preliminary results are obtained. In addition, based on our recently developed local poling techniques for ferroelectric crystals, we will also discuss and demonstrate the nonlinear complex optical field conversion in Lithium Niobate wafers with patterned ferroelectric domain structures.

The band structure of surface plasmon polaritons (SPPs) on the Ag surface in the presence of gratings and SPP-based surface-enhanced Raman scattering (SERS) are investigated theoretically and experimentally. The SPP bandgap position can be tuned by geometric parameters. The SPP band edge dominates the SERS behavior. The template stripping process is introduced to reduce SPP propagation losses, improving SERS sensitivity by ∼40. Apart from flexibility and a moderate SERS enhancement factor of the order of 105–106, the SPP band structure is highly reproducible with a relative standard deviation of 10.9%. Our results open opportunities for SPP band structures to serve as SERS substrates.

Based on nonlinear holography, we propose a 2D spirally poled LiNbO3 nonlinear photonic crystal that generates orbital angular momentum (OAM) states of second-harmonic (SH) waves. In this crystal, the generated SH waves from positive and negative domains have a π phase difference, which is used to compose a nonlinear Fresnel zone plate for an experimental demonstration of generating SH OAM states at the designed focusing spot. In addition, the crystal can be used to detect input OAM states of fundamental beams without significantly disturbing their wave fronts.

We develop an approach to fabricate arbitrary ferroelectric domain patterns on lithium niobate film (30-50 μm thick) by applying a structured external field at room temperature. The fabricating method can be operated easily to reach 1 μm linewidth resolution. The ferroelectric domain inversion is stable and uniform. Nonlinear diffraction is generated when the fundamental wave pumps to film. Various nonlinear wavefronts are obtained such as the frequency converted optical vortex beam. A nonlinear holographic concept is proposed to explain the physical phenomena and guide the corresponding domain design. The applications in optical field manipulation and novel photonic states generation are discussed.

A tunable dual-wavelength filter is experimentally demonstrated in domain-engineered lithium niobate. Application of an electric field on the y-surfaces of the sample results in the optical axes rotating clockwise and anticlockwise, which makes selective polarization rotation. The quasi phase-matching wavelengths could be adjusted through suitable domain design. A unique dual valley spectrum is obtained in a periodically poled lithium niobate structure with a central defect if the sample is placed between two parallel polarizers. The expected bandwidth could be varied from ∼1 nm to ∼40 nm. Moreover, both the spectral response and group delay dispersion could be engineered.

The present study evaluated the role of ventrolateral periaqueductal gray (vlPAG)-located orphanin-FQ (OFQ) in the opioid tolerance induced by repeated microinjections of morphine (MOR) into vlPAG. Microinjection of MOR (5 µg/0.5 µl) into vlPAG caused antinociception as quantified with the tail flick and the hot plate tests. When MOR microinjection was repeated twice daily, the antinociceptive effect disappeared within 2 days (tolerance). However, if MOR microinjection was preceded by the OFQ receptor antagonist nocistatin (NST; 1 ng/0.5 µl), the microinjections of MOR did not induce tolerance. If NST microinjections were suspended, subsequent MOR microinjections induced tolerance. In MOR-tolerant rats, a single NST microinjection into vlPAG was enough to restore the antinociceptive effect of MOR. Furthermore, if OFQ (1 ng/0.5 µl) was microinjected into vlPAG, then a MOR microinjection administered 15 min later into vlPAG did not elicit antinociception. Finally, opioid tolerance induced by repeated systemic MOR injections (5 mg/kg, i.p.) was reversed by a single microinjection of NST into vlPAG. This emphasizes the central importance of vlPAG-located OFQ in the MOR tolerance.

It is well known that dorsal raphe nucleus (DRN) is one of the key structures for the development of opioid analgesia and tolerance. An increased activity of 'antiopioids' like orphanin-FQ (OFQ) has been proposed as a possible mechanism for opioid tolerance. The present study evaluates the role of DRN-located OFQ in the opioid analgesic tolerance induced by repeated microinjections of morphine (MOR) into DRN. Male rats were implanted with chronic guide cannulae aimed at the DRN. Microinjection of MOR (0.5 microg in 0.5 microl) into DRN caused antinociception as quantified with the tail flick and the hot plate tests. When MOR microinjection was repeated twice daily, the antinociceptive effect disappeared within 2 days (tolerance). However, if each MOR microinjection was preceded (within 15 min) by a microinjection of the OFQ receptor antagonist nocistatin (NST) (1 ng in 0.5 microl) into the same DRN site, the microinjections of MOR always produced antinociception and did not induce tolerance. If NST microinjections were suspended, subsequent MOR microinjections induced tolerance. In MOR-tolerant rats, a single NST microinjection into the same DRN site was enough to restore the antinociceptive effect of MOR. On the other hand, if OFQ (1 ng in 0.5 microl) was microinjected into DRN, then MOR microinjection administered 15 min later into the same DRN site did not elicit antinociception. Finally, opioid tolerance induced by repeated systemic MOR injections (5 mg/kg, i.p.) was reversed by a single microinjection of NST into DRN. This emphasizes the central importance of DRN-located OFQ in the MOR analgesic tolerance.

Optical vortices have great potentials in optical communications, quantum computations, micro-manipulations and so on. At present, fast switching and reconfiguring of these beam vortices are still challenges. We proposed a blue phase liquid crystal fork grating by applying a vertical electric field with a forked electrode to the polymer stabilized blue phase liquid crystal cell. A fork shaped phase profile with alternation of isotropic and ordinary refractive indices in the lateral direction is thus obtained. Both fork gratings and fork grating array with different topological charges are demonstrated. They permit rapid optical vortex switching and topological charge tuning, and also exhibit excellent polarization independency and high efficiency.

The nonmaximally entangled state is a special kind of entangled state, which has important applications in quantum information processing. It has been generated in quantum circuits based on bulk optical elements. However, corresponding schemes in integrated quantum circuits have been rarely considered. In this Letter, we propose an effective solution for this problem. An electro-optically tunable nonmaximally mode-entangled photon state is generated in an on-chip domain-engineered lithium niobate (LN) waveguide. Spontaneous parametric down-conversion and electro-optic interaction are effectively combined through suitable domain design to transform the entangled state into our desired formation. Moreover, this is a flexible approach to entanglement architectures. Other kinds of reconfigurable entanglements are also achievable through this method. LN provides a very promising platform for future quantum circuit integration.