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Diabetes mellitus (DM) is a chronic systemic disease characterized by hyperglycemia, with various pathogenic mechanisms. From absolute or relative insulin deficiency, patients with DM often demonstrate various levels of metabolic disorders. Major clinical manifestations of DM include metabolic disorders, vascular lesions, circulatory disturbances and neurologic complications. Along with advances in DM research, reports of DM related tinnitus and hearing impairment have increased continuously. Research on DM related auditory system dysfunction has focused on cochlear microcirculation, cellular homeostasis, genetics and aging. Cochlear microcirculation plays an important role in cochlear physiology and its disorders are associated with many inner ear diseases. Ischemia and subsequent reperfusion seen in cochlear microcirculation disorders are important factors in hearing damage. Understanding cochlear microcirculation and structural as well as functional changes in DM patients with hearing loss and their causal factors will help reveal pathogenic mechanisms in diabetic hearing loss and provide new ideas in developing interventions and preventing damages caused by diabetes.

We discussed the influence of Jiangtang Fanglong capsule (glucose-lowering deaf-preventing capsule) to hearing of experimental diabetic deaf animal model. The experimental diabetic deaf animal model was replicated by disposable intraperitoneal injection of 55mg/kg streptozotocin(STZ) to every Wistar rats. 40 Wistar rats were randomly divided into two groups, treatment group treated by 10g•kg-1•d-1 Jiangtang Fanglong capsule suspension in intragastric gavage, and control group by equivalent normal saline, the two groups were separately accepted auditory brainstem response(ABR) detection in first month,second month,third month after model establishment. After first month, the latency and inter period of each wave of ABR of two groups were no significantly difference(P>0.05);and after second, third month, the latency and inter period of each wave of ABR of treatment group were obviously shorter than that of control group, difference was significant(P