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215 results on '"Guo, Zongduo"'

1. High levels of blood lipid and glucose predict adverse prognosis in patients with aneurysmal subarachnoid hemorrhage

Author

Zhu Yajun, Ouyang Diqing, Lei Xingwei, Tang Liuyang, Zhang Xiaofeng, Li Xiaoguo, and Guo Zongduo

Subjects
aSAH, Lipid levels, Blood glucose level, Prognosis, Science (General), Q1-390, Social sciences (General), H1-99
Abstract

Objective: We conducted a retrospective study on the prognostic factors of aneurysmal subarachnoid hemorrhage (aSAH) patients in the author's Hospital from January 2019 to May 2023. To discuss the association of the blood lipid and glucose levels of patients with the prognosis of aSAH, and verify that high blood lipid and glucose levels are important factors affecting adverse prognosis. Methods: All patients with aSAH were collected as the case group, which was divided into two groups according to the modified Rankin Scores (mRS), the good prognosis group (Group A, mRS ＜ 3) and the adverse prognosis group (Group B,mRS ≥3). The clinical data of age, gender, accompanied chronic diseases (hypertension, diabetes), smoking, drinking, Glasgow Coma Scale (GCS), Hunt-Hess (H-H) grade, Modified Fisher grade, total cholesterol (TC) , triglyceride (TG) , high-density cholesterol lipoprotein (HDL-C) , low-density cholesterol lipoprotein (LDL-C) , blood glucose (BG) , responsible aneurysm diameter and location were recorded too. Correlations between blood lipid and glucose levels and Modified Fisher grade were assessed by the Spearman correlation analysis. The receiver operating characteristic (ROC) curve was utilized to evaluate the diagnostic efficacy. The effect of blood lipid and glucose levels on adverse prognosis was analyzed by Logistic regression models. Result: A total of 259 patients with aSAH were enrolled. The average age of all patients is (56.54 ± 10.52) years, including 96 males and 163 females. They were divided into Group A (n = 146) and Group B (n = 113). Univariate analysis results show that age, the levels of TC, TG, LDL-C, and BG were higher in Group B (P

Published
2024
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13. Correlation between changes of brain volume and prognosis after aneurysmal subarachnoid hemorrhage

Author

QIN Bin, HUANG Zhijian, YU Jinhui, GUO Zongduo, HE Zhaohui, and SUN Xiaochuan

Subjects
aneurysm subarachnoid hemorrhage, 3d-slicer, change of brain volume, prognosis, Medicine (General), R5-920
Abstract

Objective To investigate the rule of change of brain volume (COBV) in 1 week after aneurysmal subarachnoid hemorrhage (aSAH), and determine the influences of COBV and change rate of brain volume (CRBV) on the prognosis of patients. Methods The clinical data of spontaneous aSAH patients admitted to the Neurosurgery Intensive Care Unit (NSICU) of the First Affiliated Hospital of Chongqing Medical University from January to August 2019 were retrospectively collected and analyzed. 3D-Slicer biomedical image computing platform was used to measure the brain volume (BV) on the 1st, 5th and 7th days after hemorrhage according to CT scans. The COBV was defined as maximum brain volume (BVmax) minus minimum brain volume (BVmin) within 1 week after bleeding, and the CRBV was the proportion of the COBV to the volume of cranial cavity×100%. According to the results of modified Rankin scale (mRS) in 3 months after bleeding, the patients were divided into good prognosis group (mRS: 1~2) and poor prognosis group (mRS: 3~5). Multivariate logistic regression analysis was adopted to analyze the independent risk factors for poor prognosis. Receiver operating characteristic (ROC) curve was drawn to evaluate the predictive value of COBV and CRBV for poor prognosis. Results For the 89 enrolled aSAH patients, the BV on the 5th day after hemorrhage (early stage after aSAH) was 1 193.9±108.7 mL, significantly larger than those at the other 2 time points (P < 0.05). Multivariate logistic regression analysis showed that COBV and CRBV were independent risk factors for poor prognosis in the patients. ROC curve analysis indicated that for COBV and CRBV, the area under curve (AUC) was 0.878 and 0.882, the best predictive cut-off values were 72.1 mL and 5.6%, with a sensitivity of 79.4% and 79.4% and specificity of 87.3% and 89.1%, respectively. Conclusion In the early stage of aSAH, the BV on the 5th day is significantly larger than that on the 1st and 7th days after hemorrhage. COBV and CRBV are independent risk factors for poor prognosis in aSAH patients.

Published
2021
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35. Dynamic Measurements of Cerebral Blood Flow Responses to Cortical Spreading Depolarization in the Murine Endovascular Perforation Subarachnoid Hemorrhage Model

Author

Yan, Jin, primary, Li, Wenlang, additional, Zhou, Chao, additional, Wu, Na, additional, Yang, Xiaomin, additional, Pan, Qiuling, additional, He, Tao, additional, Wu, Yue, additional, Guo, Zongduo, additional, Xia, Yongzhi, additional, Sun, Xiaochuan, additional, and Cheng, Chongjie, additional

Published
2022
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