Author: "Guo, Z." - Searchworks@Jio Institute Digital Library Search Results

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26,815 results on '"Guo, Z."'

1. Extragalactic fast X-ray transient from a weak relativistic jet associated with a Type Ic-BL supernova

Author: Sun, H., Li, W. -X., Liu, L. -D., Gao, H., Wang, X. -F., Yuan, W., Zhang, B., Filippenko, A. V., Xu, D., An, T., Ai, S., Brink, T. G., Liu, Y., Liu, Y. -Q., Wang, C. -Y., Wu, Q. -Y., Wu, X. -F., Yang, Y., Zhang, B. -B., Zheng, W. -K., Ahumada, T., Dai, Z. -G., Delaunay, J., Elias-Rosa, N., Benetti, S., Fu, S. -Y., Howell, D. A., Huang, Y. -F., Kasliwal, M. M., Karambelkar, V., Stein, R., Lei, W. -H., Lian, T. -Y., Peng, Z. -K., Ridnaia, A. V., Svinkin, D. S., Wang, X. -Y., Wang, A. -L., Wei, D. -M., An, J., Andrews, M., Bai, J. -M, Dai, C. -Y., Ehgamberdiev, S. A., Fan, Z., Farah, J., Feng, H. -C., Fynbo, J. P. U., Guo, W. -J., Guo, Z., Hu, M. -K., Hu, J. -W., Jiang, S. -Q., Jin, J. -J., Li, A., Li, J. -D., Li, R. -Z., Liang, Y. -F., Ling, Z. -X., Liu, X., Mao, J. -R., McCully, C., Mirzaqulov, D., Newsome, M., Gonzalez, E. Padilla, Pan, X., Terreran, G., Tinyanont, S., Wang, B. -T., Wang, L. -Z., Wen, X. -D., Xiang, D. -F., Xue, S. -J., Yang, J., Zhu, Z. -P., Cai, Z. -M., Castro-Tirado, A. J., Chen, F. -S., Chen, H. -L., Chen, T. -X., Chen, W., Chen, Y. -H., Chen, Y. -F., Chen, Y., Cheng, H. -Q., Cordier, B., Cui, C. -Z., Cui, W. -W., Dai, Y. -F., Fan, D. -W., Feng, H., Guan, J., Han, D. -W., Hou, D. -J., Hu, H. -B., Huang, M. -H., Huo, J., Jia, S. -M., Jia, Z. -Q., Jiang, B. -W., Jin, C. -C., Jin, G., Kuulkers, E., Li, C. -K., Li, D. -Y., Li, J. -F., Li, L. -H., Li, M. -S., Li, W., Li, Z. -D., Liu, C. -Z, Liu, H. -Y., Liu, H. -Q., Liu, M. -J., Lu, F. -J., Luo, L. -D., Ma, J., Mao, X., Nandra, K., O'Brien, P., Pan, H. -W., Rau, A., Rea, N., Sanders, J., Song, L. -M., Sun, S. -L., Sun, X. -J., Tan, Y. -Y., Tang, Q. -J., Tao, Y. -H., Wang, H., Wang, J., Wang, L., Wang, W. -X., Wang, Y. -L., Wang, Y. -S., Xiong, D. -R., Xu, H. -T., Xu, J. -J., Xu, X. -P., Xu, Y. -F., Xu, Z., Xue, C. -B., Xue, Y. -L., Yan, A. -L., Yang, H. -N., Yang, X. -T., Yang, Y. -J., Zhang, C., Zhang, J., Zhang, M., Zhang, S. -N., Zhang, W. -D., Zhang, W. -J., Zhang, Y. -H., Zhang, Z., Zhang, Z. -L., Zhao, D. -H., Zhao, H. -S., Zhao, X. -F., Zhao, Z. -J., Zhou, Y. -L., Zhu, Y. -X., and Zhu, Z. -C.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: Massive stars end their life as core-collapse supernovae, amongst which some extremes are Type Ic broad-lined supernovae associated with long-duration gamma-ray bursts (LGRBs) having powerful relativistic jets. Their less-extreme brethren make unsuccessful jets that are choked inside the stars, appearing as X-ray flashes or low-luminosity GRBs. On the other hand, there exists a population of extragalactic fast X-ray transients (EFXTs) with timescales ranging from seconds to thousands of seconds, whose origins remain obscure. Known sources that contribute to the observed EFXT population include the softer analogs of LGRBs, shock breakouts of supernovae, or unsuccessful jets. Here, we report the discovery of the bright X-ray transient EP240414a detected by the Einstein Probe (EP), which is associated with the Type Ic supernova SN 2024gsa at a redshift of 0.401. The X-ray emission evolution is characterised by a very soft energy spectrum peaking at < 1.3 keV, which makes it distinct from known LGRBs, X-ray flashes, or low-luminosity GRBs. Follow-up observations at optical and radio bands revealed the existence of a weak relativistic jet that interacts with an extended shell surrounding the progenitor star. Located on the outskirts of a massive galaxy, this event reveals a new population of explosions of Wolf-Rayet stars characterised by a less powerful engine that drives a successful but weak jet, possibly owing to a progenitor star with a smaller core angular momentum than in traditional LGRB progenitors., Comment: 43 pages, 9 figures, 4 tables, submitted. Comments are welcome
Published: 2024

2. The VISTA Variables in the V\'ia L\'actea eXtended (VVVX) ESO public survey: Completion of the observations and legacy

Author: Saito, R. K., Hempel, M., Alonso-García, J., Lucas, P. W., Minniti, D., Alonso, S., Baravalle, L., Borissova, J., Caceres, C., Chené, A. N., Cross, N. J. G., Duplancic, F., Garro, E. R., Gómez, M., Ivanov, V. D., Kurtev, R., Luna, A., Majaess, D., Navarro, M. G., Pullen, J. B., Rejkuba, M., Sanders, J. L., Smith, L. C., Albino, P. H. C., Alonso, M. V., Amôres, E. B., Angeloni, R., Arias, J. I., Arnaboldi, M., Barbuy, B., Bayo, A., Beamin, J. C., Bedin, L. R., Bellini, A., Benjamin, R. A., Bica, E., Bonatto, C. J., Botan, E., Braga, V. F., Brown, D. A., Cabral, J. B., Camargo, D., Garatti, A. Caratti o, Carballo-Bello, J. A., Catelan, M., Chavero, C., Chijani, M. A., Clariá, J. J., Coldwell, G. V., Peña, C. Contreras, Ramos, R. Contreras, Corral-Santana, J. M., Cortés, C. C., Cortés-Contreras, M., Cruz, P., Daza-Perilla, I. V., Debattista, V. P., Dias, B., Donoso, L., D'Souza, R., Emerson, J. P., Federle, S., Fermiano, V., Fernandez, J., Fernández-Trincado, J. G., Ferreira, T., Lopes, C. E. Ferreira, Firpo, V., Flores-Quintana, C., Fraga, L., Froebrich, D., Galdeano, D., Gavignaud, I., Geisler, D., Gerhard, O. E., Gieren, W., Gonzalez, O. A., Gramajo, L. V., Gran, F., Granitto, P. M., Griggio, M., Guo, Z., Gurovich, S., Hilker, M., Jones, H. R. A., Kammers, R., Kuhn, M. A., Kumar, M. S . N., Kundu, R., Lares, M., Libralato, M., Lima, E., Maccarone, T. J., Cortés, P. Marchant, Martin, E. L., Masetti, N., Matsunaga, N., Mauro, F., McDonald, I., Mejías, A., Mesa, V., Milla-Castro, F. P., Minniti, J. H., Bidin, C. Moni, Montenegro, K., Morris, C., Motta, V., Navarete, F., Molina, C. Navarro, Nikzat, F., Castellón, J. L. Nilo, Obasi, C., Ortigoza-Urdaneta, M., Palma, T., Parisi, C., Ramírez, K. Pena, Pereyra, L., Perez, N., Petralia, I., Pichel, A., Pignata, G., Alegría, S. Ramírez, Rojas, A. F., Rojas, D., Roman-Lopes, A., Rovero, A. C., Saroon, S., Schmidt, E. O., Schröder, A. C., Schultheis, M., Sgró, M. A., Solano, E., Soto, M., Stecklum, B., Steeghs, D., Tamura, M., Tissera, P., Valcarce, A. A. R., Valotto, C. A., Vasquez, S., Villalon, C., Villanova, S., Cádiz, F. Vivanco, Bacigalupo, R. Zelada, Zijlstra, A., and Zoccali, M.
Subjects: Astrophysics - Astrophysics of Galaxies, Astrophysics - Solar and Stellar Astrophysics
Abstract: The ESO public survey VISTA Variables in the V\'ia L\'actea (VVV) surveyed the inner Galactic bulge and the adjacent southern Galactic disk from $2009-2015$. Upon its conclusion, the complementary VVV eXtended (VVVX) survey has expanded both the temporal as well as spatial coverage of the original VVV area, widening it from $562$ to $1700$ sq. deg., as well as providing additional epochs in $JHK_{\rm s}$ filters from $2016-2023$. With the completion of VVVX observations during the first semester of 2023, we present here the observing strategy, a description of data quality and access, and the legacy of VVVX. VVVX took $\sim 2000$ hours, covering about 4% of the sky in the bulge and southern disk. VVVX covered most of the gaps left between the VVV and the VISTA Hemisphere Survey (VHS) areas and extended the VVV time baseline in the obscured regions affected by high extinction and hence hidden from optical observations. VVVX provides a deep $JHK_{\rm s}$ catalogue of $\gtrsim 1.5\times10^9$ point sources, as well as a $K_{\rm s}$ band catalogue of $\sim 10^7$ variable sources. Within the existing VVV area, we produced a $5D$ map of the surveyed region by combining positions, distances, and proper motions of well-understood distance indicators such as red clump stars, RR Lyrae, and Cepheid variables. In March 2023 we successfully finished the VVVX survey observations that started in 2016, an accomplishment for ESO Paranal Observatory upon 4200 hours of observations for VVV+VVVX. The VVV+VVVX catalogues complement those from the Gaia mission at low Galactic latitudes and provide spectroscopic targets for the forthcoming ESO high-multiplex spectrographs MOONS and 4MOST., Comment: 17 pages, 11 figures (+ appendix). Accepted for publication in Astronomy and Astrophysics in section 14: Catalogs and data
Published: 2024
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3. Measurement of Electron Antineutrino Oscillation Amplitude and Frequency via Neutron Capture on Hydrogen at Daya Bay

Author: Daya Bay collaboration, An, F. P., Bai, W. D., Balantekin, A. B., Bishai, M., Blyth, S., Cao, G. F., Cao, J., Chang, J. F., Chang, Y., Chen, H. S., Chen, H. Y., Chen, S. M., Chen, Y., Chen, Y. X., Chen, Z. Y., Cheng, J., Cheng, Y. -C., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Dalager, O., Deng, F. S., Ding, X. Y., Ding, Y. Y., Diwan, M. V., Dohnal, T., Dolzhikov, D., Dove, J., Duyang, H. Y., Dwyer, D. A., Gallo, J. P., Gonchar, M., Gong, G. H., Gong, H., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Han, Y., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, J. H., Huang, X. T., Huang, Y. B., Huber, P., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Langford, T. J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, H. L., Li, J. J., Li, Q. J., Li, R. H., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Liu, J. X., Lu, C., Lu, H. Q., Luk, K. B., Ma, B. Z., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mandujano, R. C., Marshall, C., McDonald, K. T., McKeown, R. D., Meng, Y., Napolitano, J., Naumov, D., Naumova, E., Nguyen, T. M. T., Ochoa-Ricoux, J. P., Olshevskiy, A., Park, J., Patton, S., Peng, J. C., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Reveco, C. Morales, Rosero, R., Roskovec, B., Ruan, X. C., Russell, B., Steiner, H., Sun, J. L., Tmej, T., Treskov, K., Tse, W. -H., Tull, C. E., Tung, Y. C., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z. M., Wei, H. Y., Wei, L. H., Wei, W., Wen, L. J., Whisnant, K., White, C. G., Wong, H. L. H., Worcester, E., Wu, D. R., Wu, Q., Wu, W. J., Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, H. K., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zavadskyi, V., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. L., Zhang, J. W., Zhang, Q. M., Zhang, S. Q., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, R. Z., Zhou, L., Zhuang, H. L., and Zou, J. H.
Subjects: High Energy Physics - Experiment
Abstract: This Letter reports the first measurement of the oscillation amplitude and frequency of reactor antineutrinos at Daya Bay via neutron capture on hydrogen using 1958 days of data. With over 3.6 million signal candidates, an optimized candidate selection, improved treatment of backgrounds and efficiencies, refined energy calibration, and an energy response model for the capture-on-hydrogen sensitive region, the relative $\overline{\nu}_{e}$ rates and energy spectra variation among the near and far detectors gives $\mathrm{sin}^22\theta_{13} = 0.0759_{-0.0049}^{+0.0050}$ and $\Delta m^2_{32} = (2.72^{+0.14}_{-0.15})\times10^{-3}$ eV$^2$ assuming the normal neutrino mass ordering, and $\Delta m^2_{32} = (-2.83^{+0.15}_{-0.14})\times10^{-3}$ eV$^2$ for the inverted neutrino mass ordering. This estimate of $\sin^2 2\theta_{13}$ is consistent with and essentially independent from the one obtained using the capture-on-gadolinium sample at Daya Bay. The combination of these two results yields $\mathrm{sin}^22\theta_{13}= 0.0833\pm0.0022$, which represents an 8% relative improvement in precision regarding the Daya Bay full 3158-day capture-on-gadolinium result.
Published: 2024
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4. Search for a sub-eV sterile neutrino using Daya Bay's full dataset

Author: An, F. P., Bai, W. D., Balantekin, A. B., Bishai, M., Blyth, S., Cao, G. F., Cao, J., Chang, J. F., Chang, Y., Chen, H. S., Chen, H. Y., Chen, S. M., Chen, Y., Chen, Y. X., Chen, Z. Y., Cheng, J., Cheng, Y. C., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Dalager, O., Deng, F. S., Ding, X. Y., Ding, Y. Y., Diwan, M. V., Dohnal, T., Dolzhikov, D., Dove, J., Dugas, K. V., Duyang, H. Y., Dwyer, D. A., Gallo, J. P., Gonchar, M., Gong, G. H., Gong, H., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Han, Y., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, J. H., Huang, X. T., Huang, Y. B., Huber, P., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Langford, T. J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, H. L., Li, J. J., Li, Q. J., Li, R. H., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Liu, J. X., Lu, C., Lu, H. Q., Luk, K. B., Ma, B. Z., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mandujano, R. C., Marshall, C., McDonald, K. T., McKeown, R. D., Meng, Y., Napolitano, J., Naumov, D., Naumova, E., Nguyen, T. M. T., Ochoa-Ricoux, J. P., Olshevskiy, A., Park, J., Patton, S., Peng, J. C., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Reveco, C. Morales, Rosero, R., Roskovec, B., Ruan, X. C., Russell, B., Steiner, H., Sun, J. L., Tmej, T., Tse, W. -H., Tull, C. E., Tung, Y. C., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z. M., Wei, H. Y., Wei, L. H., Wei, W., Wen, L. J., Whisnant, K., White, C. G., Wong, H. L. H., Worcester, E., Wu, D. R., Wu, Q., Wu, W. J., Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, H. K., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zavadskyi, V., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. L., Zhang, J. W., Zhang, Q. M., Zhang, S. Q., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, R. Z., Zhou, L., Zhuang, H. L., and Zou, J. H.
Subjects: High Energy Physics - Experiment
Abstract: This Letter presents results of a search for the mixing of a sub-eV sterile neutrino with three active neutrinos based on the full data sample of the Daya Bay Reactor Neutrino Experiment, collected during 3158 days of detector operation, which contains $5.55 \times 10^{6}$ reactor \anue candidates identified as inverse beta-decay interactions followed by neutron-capture on gadolinium. The analysis benefits from a doubling of the statistics of our previous result and from improvements of several important systematic uncertainties. No significant oscillation due to mixing of a sub-eV sterile neutrino with active neutrinos was found. Exclusion limits are set by both Feldman-Cousins and CLs methods. Light sterile neutrino mixing with $\sin^2 2\theta_{14} \gtrsim 0.01$ can be excluded at 95\% confidence level in the region of $0.01$ eV$^2 \lesssim |\Delta m^{2}_{41}| \lesssim 0.1 $ eV$^2$. This result represents the world-leading constraints in the region of $2 \times 10^{-4}$ eV$^2 \lesssim |\Delta m^{2}_{41}| \lesssim 0.2 $ eV$^2$., Comment: 7 pages, 4 figures, 1 table
Published: 2024

5. Non-Equilibrium and Self-Organization Evolution in Hot-Spot Ignition Processes

Author: Fu, X. -Y., Guo, Z. -Y., Wang, Q. -H., Wang, R. -C., Wu, D., and Zhang, J.
Subjects: Physics - Plasma Physics
Abstract: Due to disparate formation mechanisms, as for central hot-spot ignition and fast ignition, the initial temperatures of electron and ions usually differs from each other in the hot spot. Considering the percipient dependence of fusion cross-section and energy losses on temperature, this difference manifests the inadequacy of the equilibrium theoretical model in accurately depicting the ignition condition and evolution of the hot-spot. In this work, we studied a non-equilibrium model and extended this model to both isobaric and isochoric scenarios, characterized by varying hot-spot densities, temperatures and expansion velocities. In both cases, a spontaneous self-organization evolution was observed, manifesting as the bifurcation of ion and electron temperatures. Notably, the ion temperature is particularly prominent during the ignition process. This inevitability can be traced to the preponderant deposition rates of alpha-particles into D-T ions and the decreasing rate of energy exchange between electrons and D-T ions at elevated temperatures. The inherent structure, characterized by higher ion temperature and lower electron temperature during ignition, directly contributes to the augmentation of D-T reactions and mitigates energy losses through electron conduction and bremsstrahlung, thereby naturally facilitating nuclear fusions., Comment: The junior undergraduate students, X.-Y. Fu, Z.-Y. Guo, Q.-H. Wang, and R.-C. Wang, all contributed equally to this work
Published: 2024

6. First measurement of the yield of $^8$He isotopes produced in liquid scintillator by cosmic-ray muons at Daya Bay

Author: Daya Bay Collaboration, An, F. P., Bai, W. D., Balantekin, A. B., Bishai, M., Blyth, S., Cao, G. F., Cao, J., Chang, J. F., Chang, Y., Chen, H. S., Chen, H. Y., Chen, S. M., Chen, Y., Chen, Y. X., Chen, Z. Y., Cheng, J., Cheng, Y. C., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Dalager, O., Deng, F. S., Ding, X. Y., Ding, Y. Y., Diwan, M. V., Dohnal, T., Dolzhikov, D., Dove, J., Dugas, K. V., Duyang, H. Y., Dwyer, D. A., Gallo, J. P., Gonchar, M., Gong, G. H., Gong, H., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Han, Y., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, J. H., Huang, X. T., Huang, Y. B., Huber, P., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Langford, T. J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, H. L., Li, J. J., Li, Q. J., Li, R. H., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Liu, J. X., Lu, C., Lu, H. Q., Luk, K. B., Ma, B. Z., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mandujano, R. C., Marshall, C., McDonald, K. T., McKeown, R. D., Meng, Y., Napolitano, J., Naumov, D., Naumova, E., Nguyen, T. M. T., Ochoa-Ricoux, J. P., Olshevskiy, A., Park, J., Patton, S., Peng, J. C., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Reveco, C. Morales, Rosero, R., Roskovec, B., Ruan, X. C., Russell, B., Steiner, H., Sun, J. L., Tmej, T., Tse, W. -H., Tull, C. E., Tung, Y. C., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z. M., Wei, H. Y., Wei, L. H., Wei, W., Wen, L. J., Whisnant, K., White, C. G., Wong, H. L. H., Worcester, E., Wu, D. R., Wu, Q., Wu, W. J., Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, H. K., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zavadskyi, V., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. L., Zhang, J. W., Zhang, Q. M., Zhang, S. Q., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, R. Z., Zhou, L., Zhuang, H. L., and Zou, J. H.
Subjects: Nuclear Experiment, High Energy Physics - Experiment
Abstract: Daya Bay presents the first measurement of cosmogenic $^8$He isotope production in liquid scintillator, using an innovative method for identifying cascade decays of $^8$He and its child isotope, $^8$Li. We also measure the production yield of $^9$Li isotopes using well-established methodology. The results, in units of 10$^{-8}\mu^{-1}$g$^{-1}$cm$^{2}$, are 0.307$\pm$0.042, 0.341$\pm$0.040, and 0.546$\pm$0.076 for $^8$He, and 6.73$\pm$0.73, 6.75$\pm$0.70, and 13.74$\pm$0.82 for $^9$Li at average muon energies of 63.9~GeV, 64.7~GeV, and 143.0~GeV, respectively. The measured production rate of $^8$He isotopes is more than an order of magnitude lower than any other measurement of cosmogenic isotope production. It replaces the results of previous attempts to determine the ratio of $^8$He to $^9$Li production that yielded a wide range of limits from 0 to 30\%. The results provide future liquid-scintillator-based experiments with improved ability to predict cosmogenic backgrounds.
Published: 2024

7. Effects of Vitamin D3 Combined with Folic Acid on Domain and Specific Cognitive Function among Patients with Mild Cognitive Impairment: A Randomized Clinical Trial

Author: Liu, Wen, Zheng, Deqiang, Li, X., Wang, T., Wang, L., Hao, L., Ju, M., Feng, W., Guo, Z., Sun, X., Yu, H., Qin, Z., and Xiao, Rong
Published: 2024
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8. The most variable VVV sources: eruptive protostars, dipping giants in the Nuclear Disc and others

Author: Lucas, P. W., Smith, L. C., Guo, Z., Peña, C. Contreras, Minniti, D., Miller, N., Alonso-García, J., Catelan, M., Borissova, J., Saito, R. K., Kurtev, R., Navarro, M. G., Morris, C., Muthu, H., Froebrich, D., Ivanov, V. D., Bayo, A., Garatti, A. Caratti o, and Sanders, J. L.
Subjects: Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Astrophysics of Galaxies
Abstract: We have performed a comprehensive search of a VISTA Variables in the Via Lactea (VVV) database of 9.5 yr light curves for variable sources with $\Delta K_s \ge 4$ mag, aiming to provide a large sample of high amplitude eruptive young stellar objects (YSOs) and detect unusual or new types of infrared variable source. We find 222 variable or transient sources in the Galactic bulge and disc, most of which are new discoveries. The sample mainly comprises novae, YSOs, microlensing events, Long Period Variable stars (LPVs) and a few rare or unclassified sources. Additionally, we report the discovery of a significant population of aperiodic late-type giant stars suffering deep extinction events, strongly clustered in the Nuclear Disc of the Milky Way. We suggest that these are metal-rich stars in which radiatively driven mass loss has been enhanced by super-solar metallicity. Among the YSOs, 32/40 appear to be undergoing episodic accretion. Long-lasting YSO eruptions have a typical rise time of $\sim$2 yr, somewhat slower than the 6-12 month timescale seen in the few historical events observed on the rise. The outburst durations are usually at least 5 yr, somewhat longer than many lower amplitude VVV events detected previously. The light curves are diverse in nature, suggesting that multiple types of disc instability may occur. Eight long-duration extinction events are seen wherein the YSO dims for a year or more, attributable to inner disc structure. One binary YSO in NGC 6530 displays periodic extinction events (P=59 days) similar to KH 15D., Comment: Accepted by MNRAS. 38 pages. Full source lists and light curves are available in the Ancillary Files
Published: 2024
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9. Charged-current non-standard neutrino interactions at Daya Bay

Author: Daya Bay collaboration, An, F. P., Bai, W. D., Balantekin, A. B., Bishai, M., Blyth, S., Cao, G. F., Cao, J., Chang, J. F., Chang, Y., Chen, H. S., Chen, H. Y., Chen, S. M., Chen, Y., Chen, Y. X., Chen, Z. Y., Cheng, J., Cheng, Y. C., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Dalager, O., Deng, F. S., Ding, X. Y., Ding, Y. Y., Diwan, M. V., Dohnal, T., Dolzhikov, D., Dove, J., Dugas, K. V., Duyang, H. Y., Dwyer, D. A., Gallo, J. P., Gonchar, M., Gong, G. H., Gong, H., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Han, Y., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, J. H., Huang, X. T., Huang, Y. B., Huber, P., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Langford, T. J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, H. L., Li, J. J., Li, Q. J., Li, R. H., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Liu, J. X., Lu, C., Lu, H. Q., Luk, K. B., Ma, B. Z., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mandujano, R. C., Marshall, C., McDonald, K. T., McKeown, R. D., Meng, Y., Napolitano, J., Naumov, D., Naumova, E., Nguyen, T. M. T., Ochoa-Ricoux, J. P., Olshevskiy, A., Park, J., Patton, S., Peng, J. C., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Reveco, C. Morales, Rosero, R., Roskovec, B., Ruan, X. C., Russell, B., Steiner, H., Sun, J. L., Tmej, T., Tse, W. -H., Tull, C. E., Tung, Y. C., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z. M., Wei, H. Y., Wei, L. H., Wei, W., Wen, L. J., Whisnant, K., White, C. G., Wong, H. L. H., Worcester, E., Wu, D. R., Wu, Q., Wu, W. J., Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, H. K., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zavadskyi, V., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. L., Zhang, J. W., Zhang, Q. M., Zhang, S. Q., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, R. Z., Zhou, L., Zhuang, H. L., and Zou, J. H.
Subjects: High Energy Physics - Phenomenology, High Energy Physics - Experiment
Abstract: The full data set of the Daya Bay reactor neutrino experiment is used to probe the effect of the charged current non-standard interactions (CC-NSI) on neutrino oscillation experiments. Two different approaches are applied and constraints on the corresponding CC-NSI parameters are obtained with the neutrino flux taken from the Huber-Mueller model with a $5\%$ uncertainty. For the quantum mechanics-based approach (QM-NSI), the constraints on the CC-NSI parameters $\epsilon_{e\alpha}$ and $\epsilon_{e\alpha}^{s}$ are extracted with and without the assumption that the effects of the new physics are the same in the production and detection processes, respectively. The approach based on the weak effective field theory (WEFT-NSI) deals with four types of CC-NSI represented by the parameters $[\varepsilon_{X}]_{e\alpha}$. For both approaches, the results for the CC-NSI parameters are shown for cases with various fixed values of the CC-NSI and the Dirac CP-violating phases, and when they are allowed to vary freely. We find that constraints on the QM-NSI parameters $\epsilon_{e\alpha}$ and $\epsilon_{e\alpha}^{s}$ from the Daya Bay experiment alone can reach the order $\mathcal{O}(0.01)$ for the former and $\mathcal{O}(0.1)$ for the latter, while for WEFT-NSI parameters $[\varepsilon_{X}]_{e\alpha}$, we obtain $\mathcal{O}(0.1)$ for both cases., Comment: 25 pages, 16 figures, 6 tables; 36 pages, format changed, references added
Published: 2024

10. Dynamic Characteristics of the Droplet Impact on the Ultracold Surface under the Engine Cold Start Conditions

Author: Jin, S., Zhang, W., Guo, Z., Yuan, Y., Shi, Z., Liu, Y., and Yan, J.
Published: 2024
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11. Failure Analysis of Thickness Gradient Negative Poisson’s Ratio Concave Honeycomb Sandwich Panels Under Local Impact

Author: Xiao, J. H. and Guo, Z. X.
Published: 2024
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12. Unleashing AdipoRon’s Potential: A Fresh Approach to Tackle Pseudomonas aeruginosa Infections in Bronchiectasis via Sphingosine Metabolism Modulation

Author: Xu JW, Chen FF, Qv YH, Sun CC, Zhang D, Guo Z, Wang YJ, Wang JF, Liu T, Dong L, and Qi Q
Subjects: adiporon, pseudomonas aeruginosa, bronchiectasis, adipor1, sphingosine metabolism, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract: Jia-wei Xu,1,2,&ast; Fang-fang Chen,1,&ast; Ying-hui Qv,1,&ast; Cong-cong Sun,1 Dong Zhang,1,2 Zhi Guo,1 Yu-jiao Wang,3 Jun-fei Wang,4 Tian Liu,4 Liang Dong,1,2 Qian Qi1,2 1Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Institute of Respiratory Diseases, Shandong Characteristic Laboratory of Clinical Transformation of Respiratory Biological Immunity and Regenerative Medicine, Jinan, Shandong Province, 250014, People’s Republic of China; 2Department of Pulmonary and Critical Care Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong Province, 250014, People’s Republic of China; 3Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Laboratory Medicine, Jinan, Shandong Province, 250014, People’s Republic of China; 4Department of Pulmonary and Critical Care Medicine, Qilu Hospital, Shandong University, Jinan, Shandong Province, 250012, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Qian Qi, Department of Pulmonary and Critical Care Medicine, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, &num;16766, Jingshi Road, Jinan City, Shandong Province, 250014, People’s Republic of China, Tel +86 13706380314, Email qiqianqlh@163.comPurpose: Bronchiectasis patients are prone to Pseudomonas aeruginosa infection due to decreased level of sphingosine in airway. Adiponectin receptor agonist AdipoRon activates the intrinsic ceramidase activity of adiponectin receptor 1 (AdipoR1) and positively regulates sphingosine metabolism. This study aimed to investigate the potential therapeutic benefit of AdipoRon against Pseudomonas aeruginosa infection.Methods: A mouse model of Pseudomonas aeruginosa lung infection and a co-culture model of human bronchial epithelial cells with Pseudomonas aeruginosa were established to explore the protective effect of AdipoRon. Liquid chromatography-mass spectrometry was used to detect the effect of AdipoRon on sphingosine level in lung of Pseudomonas aeruginosa-infected mouse models.Results: The down-regulation of adiponectin and AdipoR1 in airway of bronchiectasis patients was linked to Pseudomonas aeruginosa infection. By activating AdipoR1, AdipoRon reduced Pseudomonas aeruginosa adherence on bronchial epithelial cells and protected cilia from damage in vitro. With the treatment of AdipoRon, the load of Pseudomonas aeruginosa in lung significantly decreased, and peribronchial inflammatory cell infiltration was lessened in vivo. The reduced level of sphingosine in the airway of Pseudomonas aeruginosa infected mice was replenished by AdipoRon, thus playing a protective role in the airway. Moreover, AdipoRon activated P-AMPKα/PGC1α, inhibited TLR4/P-NF-κB p65, and reduced expression of pro-apoptotic bax. However, the protective effect of AdipoRon on resisting Pseudomonas aeruginosa infection was weakened when AdipoR1 was knocked down.Conclusion: AdipoRon protects bronchial epithelial cells and lung by enhancing their resistance to Pseudomonas aeruginosa infection. The mechanism might be modulating sphingosine metabolism and activating P-AMPKα/PGC1α while inhibiting TLR4/P-NF-κB p65.Keywords: AdipoRon, Pseudomonas aeruginosa, bronchiectasis, AdipoR1, sphingosine metabolism
Published: 2024

13. Challenges in Accessing Community-Based Rehabilitation and Long-Term Care for Older Adult Stroke Survivors and Their Caregivers: A Qualitative Study

Author: Zeng S, Wu M, Xu L, Guo Z, Chen S, Ling K, Li H, Yu X, and Zhu X
Subjects: stroke, survivors, caregivers, community, qualitative research, Medicine (General), R5-920
Abstract: Sining Zeng,1,2,&ast; Min Wu,1,&ast; Ling Xu,1 Zining Guo,1 Shufan Chen,1 Keyu Ling,1 Haihan Li,1 Xiaoli Yu,1 Xiaoping Zhu1 1Department of Nursing, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, 200072, People’s Republic of China; 2School of Nursing, Soochow University, Suzhou, 215031, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xiaoping Zhu, Department of Nursing, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, 200072, People’s Republic of China, Tel +86-021-66300588, Fax +86-021-66307542, Email xiaopingzhu0424@163.comBackground and Objectives: While extensive research has examined the rehabilitation challenges faced by stroke survivors, there is limited literature addressing the difficulties encountered by older adult stroke survivors and their caregivers in accessing rehabilitation and long-term care within the Chinese community. This study aimed to investigate the specific challenges related to access, quality, and coordination of rehabilitation and long-term care experienced by older adult stroke survivors and their caregivers within the Chinese community.Methods: A qualitative phenomenological design was employed to explore the lived experiences of stroke survivors and their caregivers within the Chinese community. A purposive sampling method was used to recruit participants from June to August 2023. Participants engaged in face-to-face semi-structured interviews. The data were analyzed using an inductive thematic analysis approach to identify and understand key themes and sub-themes.Results: The study involved 38 participants, consisting of 21 older adult stroke survivors (13 males, 8 females) and 17 family caregivers (7 males, 10 females), recruited from five Chinese community health service stations. The analysis identified four distinct themes and 11 sub-themes that encapsulated the challenges faced by participants. These themes include (1) Difficulties in accessing medical services (insufficient medical resources, lack of rehabilitation resources, and time-consuming processes), (2) Challenges in daily life (inconvenience in daily mobility, inadequate financial support, and difficulties in applying for home care services), (3) Psychosocial stress (loneliness, powerlessness, and worry about burdening others), (4) Insufficient information (lack of awareness of available community services, and limited public health education activities).Conclusion: Older adult stroke survivors and their caregivers in Chinese communities face significant challenges. To improve their well-being and quality of life, it is crucial to address these challenges through enhanced access to healthcare, better support for daily living, and more effective information dissemination. Meeting these needs requires a coordinated effort from healthcare providers, community stakeholders, and policymakers to develop and implement effective, long-term care solutions.Keywords: stroke, survivors, caregivers, community, qualitative research
Published: 2024

14. Gender Difference of the Association Between Sleep Duration and Myopia Among Children and Adolescents

Author: Gao Z, Guo Z, Song Y, Shi X, Zhao Y, and Liu C
Subjects: myopia, children and adolescents, sleep duration, physical activity, bmi, gender difference, Psychiatry, RC435-571, Neurophysiology and neuropsychology, QP351-495
Abstract: Zhaorong Gao,1– 3 Zhen Guo,1– 3 Yongbo Song,1– 3 Xiujing Shi,1– 3 Yingzuo Zhao,1– 3 Conghui Liu1– 3 1Qingdao Eye Hospital of Shandong First Medical University, Eye Institute of Shandong First Medical University, Qingdao, People’s Republic of China; 2State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, People’s Republic of China; 3School of Ophthalmology, Shandong First Medical University, Qingdao, People’s Republic of ChinaCorrespondence: Zhen Guo, Qingdao Eye Hospital of Shandong First Medical University, Eye Institute of Shandong First Medical University, 5 Yanerdao Road, Qingdao, Shandong, 266071, People’s Republic of China, Fax +86532 8761 0087, Email guoz@sdfmu.edu.cnPurpose: With girls typically exhibiting higher rates of myopia than boys, however, the mechanisms behind this gender difference remain unclear. This study aims to investigate the gender disparities in the relationship between myopia, sleep duration, physical activity, and BMI.Patients and Methods: A total of 3138 primary and secondary school students were included. Mplus 8.3 was used to perform the multiple mediation analysis.Results: Sleep duration was indicated to directly affect myopia (β=0.273, 95% CI=0.184− 0.356) and through physical activity, BMI, physical activity and BMI three significantly mediation pathways, respectively. In terms of gender, the mediating direct effect of sleep duration on myopia of boys was 66.96%, which is much higher than that of girls’ 50.91%. And the mediating indirect effect of sleep duration on myopia through physical activity and BMI are 32.65% and 12.10% respectively among girls, both of which are significantly higher than that of boys.Conclusion: The study found that there are significant differences in the impact of sleep duration on myopia in children and adolescents of different genders. In this regard, while paying attention to the sleep duration of children and adolescents, special attention should also be paid to the indirect impact of girls’ physical activity and BMI on myopia, and targeted measures should be formulated according to children of different genders to effectively protect the eye health of children and adolescents.Keywords: myopia, children and adolescents, sleep duration, physical activity, BMI, gender difference
Published: 2024

15. Treatment Outcomes and Associated Influencing Factors Among Patients with Rifampicin-Resistant Tuberculosis: A Multicenter, Retrospective, Cohort Study in China

Author: Zou L, Kang W, Guo C, Du J, Chen Q, Shi Z, Tang X, Liang L, Tang P, Pan Q, Zhu Q, Yang S, Chang Z, Guo Z, Wu G, and Tang S
Subjects: rr-tb, treatment outcomes, influencing factors, china, Infectious and parasitic diseases, RC109-216
Abstract: Liping Zou,1,&ast; Wanli Kang,2,&ast; Chunhui Guo,3,&ast; Juan Du,4,&ast; Qing Chen,1 Zhengyu Shi,1 Xianzhen Tang,1 Li Liang,1 Peijun Tang,5 Qing Pan,6 Qingdong Zhu,7 Song Yang,8 Zhanlin Chang,9 Zhouli Guo,1 Guihui Wu,1 Shenjie Tang2 1Department of Tuberculosis, Public Health Clinical Center of Chengdu, Chengdu, People’s Republic of China; 2Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, People’s Republic of China; 3Department of Tuberculosis, Harbin Chest Hospital, Harbin, People’s Republic of China; 4Department of Tuberculosis, Wuhan Pulmonary Hotel, Wuhan, People’s Republic of China; 5Department of Tuberculosis, the Fifth People’s Hospital of Suzhou, Suzhou, People’s Republic of China; 6Department of Respiratory and Critical Care Medicine, Anqing Municipal Hospital, Anqing, People’s Republic of China; 7Department of Tuberculosis, the Fourth People’s Hospital of Nanning, Nanning, People’s Republic of China; 8General Internal Medicine Department, Chongqing Public Health Medical Center, Chongqing, People’s Republic of China; 9Department of Surgery, the Third People’s Hospital of Tibet Autonomous Region, Lasa, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Guihui Wu, Department of Tuberculosis, Public Health Clinical Center of Chengdu, Jingjusi 18 Street, Jingjiang District, Chengdu, Sichuan, People’s Republic of China, Tel +86-28-8455-0573, Email wghwgh2584@sina.com Shenjie Tang, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, 101149, People’s Republic of China, Tel +86-13621028338, Email tangsj1106@vip.sina.comObjective: Rifampin-resistant tuberculosis (RR-TB) remains a serious global public health concern. We assessed treatment outcomes and associated influencing factors among RR-TB patients in China.Methods: This research enrolled 1339 patients who started RR-TB treatment between May 2018 and April 2020 in China retrospectively. Data were collected from the electronic medical records. Multivariable logistic regression analysis was used to identify the influencing factors related to unfavorable outcomes.Results: Of the 1339 RR-TB patients, 78.8% (1055/1339) achieved treatment success (cured or treatment completed), 5.1% (68/1339) experienced treatment failure, 1.1% (15/1339) died during treatment, 10.1% (135/1339) were lost to follow-up, and 4.9% (66/1339) were not evaluated. About 67.7% (907/1339) of patients experienced at least one adverse event (AE). The most common AE was hypohepatia (507/1339, 37.9%), followed by hyperuricemia (429/1339, 32.0%), anemia (368/1339, 27.5%), electrolyte disturbance (318/1339, 23.7%), peripheral neuritis (245/1339, 18.3%), and gastrointestinal reactions (203/1339, 15.2%). Multivariate analysis showed that age ≥ 60 years [adjusted odds ratio (aOR): 1.96, 95% confidence interval (CI): 1.39– 2.77], national minority (aOR: 2.36, 95% CI: 1.42– 3.93), smoking (aOR: 1.50, 95% CI: 1.10– 2.04), cardiopathy (aOR: 2.90, 95% CI: 1.33– 6.31), tumors (aOR: 9.84, 95% CI: 2.27– 42.67), immunocompromise (aOR: 2.17, 95% CI: 1.21– 3.91), re-treated TB (aOR: 1.46, 95% CI: 1.08– 1.97), and experienced gastrointestinal reactions (aOR: 2.27, 95% CI: 1.52– 3.40) were associated with unfavorable outcomes. Body mass index (BMI) ≥ 18.5 kg/m2, regimens containing bedaquiline and experienced adverse events (AEs) such as hypohepatia, leukopenia, peripheral neuritis, and optic neuritis were associated with favorable outcomes.Conclusion: High rates of treatment success were achieved for RR-TB patients at tertiary tuberculosis hospitals in China. Age ≥ 60 years, national minority, smoking status, comorbidities, re-treated TB, and experienced gastrointestinal reactions were independent prognostic factors for unfavorable treatment outcomes.Keywords: RR-TB, treatment outcomes, influencing factors, China
Published: 2024

16. DPSCs regulate epithelial-T cell interactions in oral submucous fibrosis

Author: Wang, S. Y., Zhang, S. J., Meng, H. F., Xu, H. Q., Guo, Z. X., Yan, J. F., Gao, J. L., Niu, L. N., Wang, S. L., and Jiao, K.
Published: 2024
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17. Effect of internal phase particle size on properties of site mixed emulsion explosive at plateau environment

Author: Xie, S. D., Cai, X. Y., Wu, H. B., Wang, Q., Guo, Z. R., Chen, Z. Y., and Ma, C. S.
Published: 2024
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18. STCF Conceptual Design Report: Volume 1 -- Physics & Detector

Author: Achasov, M., Ai, X. C., Aliberti, R., An, L. P., An, Q., Bai, X. Z., Bai, Y., Bakina, O., Barnyakov, A., Blinov, V., Bobrovnikov, V., Bodrov, D., Bogomyagkov, A., Bondar, A., Boyko, I., Bu, Z. H., Cai, F. M., Cai, H., Cao, J. J., Cao, Q. H., Cao, Z., Chang, Q., Chao, K. T., Chen, D. Y., Chen, H., Chen, H. X., Chen, J. F., Chen, K., Chen, L. L., Chen, P., Chen, S. L., Chen, S. M., Chen, S., Chen, S. P., Chen, W., Chen, X. F., Chen, X., Chen, Y., Chen, Y. Q., Cheng, H. Y., Cheng, J., Cheng, S., Dai, J. P., Dai, L. Y., Dai, X. C., Dedovich, D., Denig, A., Denisenko, I., Ding, D. Z., Dong, L. Y., Dong, W. H., Druzhinin, V., Du, D. S., Du, Y. J., Du, Z. G., Duan, L. M., Epifanov, D., Fan, Y. L., Fang, S. S., Fang, Z. J., Fedotovich, G., Feng, C. Q., Feng, X., Feng, Y. T., Fu, J. L., Gao, J., Ge, P. S., Geng, C. Q., Geng, L. S., Gilman, A., Gong, L., Gong, T., Gradl, W., Gu, J. L., Escalante, A. G., Gui, L. C., Guo, F. K., Guo, J. C., Guo, J., Guo, Y. P., Guo, Z. H., Guskov, A., Han, K. L., Han, L., Han, M., Hao, X. Q., He, J. B., He, S. Q., He, X. G., He, Y. L., He, Z. B., Heng, Z. X., Hou, B. L., Hou, T. J., Hou, Y. R., Hu, C. Y., Hu, H. M., Hu, K., Hu, R. J., Hu, X. H., Hu, Y. C., Hua, J., Huang, G. S., Huang, J. S., Huang, M., Huang, Q. Y., Huang, W. Q., Huang, X. T., Huang, X. J., Huang, Y. B., Huang, Y. S., Hüsken, N., Ivanov, V., Ji, Q. P., Jia, J. J., Jia, S., Jia, Z. K., Jiang, H. B., Jiang, J., Jiang, S. Z., Jiao, J. B., Jiao, Z., Jing, H. J., Kang, X. L., Kang, X. S., Ke, B. C., Kenzie, M., Khoukaz, A., Koop, I., Kravchenko, E., Kuzmin, A., Lei, Y., Levichev, E., Li, C. H., Li, C., Li, D. Y., Li, F., Li, G., Li, H. B., Li, H., Li, H. N., Li, H. J., Li, H. L., Li, J. M., Li, J., Li, L., Li, L. Y., Li, N., Li, P. R., Li, R. H., Li, S., Li, T., Li, W. J., Li, X. H., Li, X. Q., Li, Y., Li, Y. Y., Li, Z. J., Liang, H., Liang, J. H., Liao, G. R., Liao, L. Z., Liao, Y., Lin, C. X., Lin, X. S., Liu, B. J., Liu, C. W., Liu, D., Liu, F., Liu, G. M., Liu, H. B., Liu, J., Liu, J. J., Liu, J. B., Liu, K., Liu, K. Y., Liu, L., Liu, Q., Liu, S. B., Liu, T., Liu, X., Liu, Y. W., Liu, Y., Liu, Y. L., Liu, Z. Q., Liu, Z. Y., Liu, Z. W., Logashenko, I., Long, Y., Lu, C. G., Lu, N., Lü, Q. F., Lu, Y., Lv, Z., Lukin, P., Luo, F. J., Luo, T., Luo, X. F., Lyu, H. J., Lyu, X. R., Ma, J. P., Ma, P., Ma, Y., Maas, F., Malde, S., Matvienko, D., Meng, Z. X., Mitchell, R., Dias, J. M., Nefediev, A., Nefedov, Y., Olsen, S. L., Ouyang, Q., Pakhlov, P., Pakhlova, G., Pan, X., Pan, Y., Passemar, E., Pei, Y. P., Peng, H. P., Peng, L., Peng, X. Y., Peng, X. J., Peters, K., Pivovarov, S., Pyata, E., Qi, B. B., Qi, Y. Q., Qian, W. B., Qian, Y., Qiao, C. F., Qin, J. J., Qin, L. Q., Qin, X. S., Qiu, T. L., Rademacker, J., Redmer, C. F., Sang, H. Y., Saur, M., Shan, W., Shan, X. Y., Shang, L. L., Shao, M., Shekhtman, L., Shen, C. P., Shen, J. M., Shen, Z. T., Shi, H. C., Shi, X. D., Shwartz, B., Sokolov, A., Song, J. J., Song, W. M., Song, Y., Song, Y. X., Sukharev, A., Sun, J. F., Sun, L., Sun, X. M., Sun, Y. J., Sun, Z. P., Tang, J., Tang, S. S., Tang, Z. B., Tian, C. H., Tian, J. S., Tikhonov, Y., Todyshev, K., Uglov, T., Vorobyev, V., Wan, B. D., Wang, B. L., Wang, B., Wang, D. Y., Wang, G. Y., Wang, G. L., Wang, H. L., Wang, J., Wang, J. H., Wang, J. C., Wang, M. L., Wang, R., Wang, S. B., Wang, W., Wang, W. P., Wang, X. C., Wang, X. D., Wang, X. L., Wang, X. P., Wang, X. F., Wang, Y. D., Wang, Y. P., Wang, Y. Q., Wang, Y. L., Wang, Y. G., Wang, Z. Y., Wang, Z. L., Wang, Z. G., Wei, D. H., Wei, X. L., Wei, X. M., Wen, Q. G., Wen, X. J., Wilkinson, G., Wu, B., Wu, J. J., Wu, L., Wu, P. W., Wu, T. W., Wu, Y. S., Xia, L., Xiang, T., Xiao, C. W., Xiao, D., Xiao, M., Xie, Y. H., Xing, Y., Xing, Z. Z., Xiong, X. N., Xu, F. R., Xu, J., Xu, L. L., Xu, Q. N., Xu, X. C., Xu, X. P., Xu, Y. C., Xu, Y. P., Xu, Y., Xu, Z. Z., Xuan, D. W., Xue, F. F., Yan, L., Yan, M. J., Yan, W. B., Yan, W. C., Yan, X. S., Yang, B. F., Yang, C., Yang, H. J., Yang, H. R., Yang, H. T., Yang, J. F., Yang, S. L., Yang, Y. D., Yang, Y. H., Yang, Y. S., Yang, Y. L., Yang, Z. Y., Yao, D. L., Yin, H., Yin, X. H., Yokozaki, N., You, S. Y., You, Z. Y., Yu, C. X., Yu, F. S., Yu, G. L., Yu, H. L., Yu, J. S., Yu, J. Q., Yuan, L., Yuan, X. B., Yue, Y. F., Zeng, M., Zeng, S., Zhang, A. L., Zhang, B. W., Zhang, G. Y., Zhang, G. Q., Zhang, H. J., Zhang, H. B., Zhang, J. Y., Zhang, J. L., Zhang, J., Zhang, L., Zhang, L. M., Zhang, R., Zhang, S. L., Zhang, T., Zhang, X., Zhang, Y., Zhang, Y. X., Zhang, Y. T., Zhang, Y. F., Zhang, Y. C., Zhang, Y. M., Zhang, Y. L., Zhang, Z. H., Zhang, Z. Y., Zhao, H. Y., Zhao, J., Zhao, L., Zhao, M. G., Zhao, Q., Zhao, R. G., Zhao, R. P., Zhao, Z. G., Zhao, Z. X., Zhemchugov, A., Zheng, B., Zheng, L., Zheng, Q. B., Zheng, R., Zheng, Y. H., Zhong, X. H., Zhou, H. J., Zhou, H. Q., Zhou, H., Zhou, S. H., Zhou, X., Zhou, X. K., Zhou, X. R., Zhou, Y. L., Zhou, Y., Zhou, Y. X., Zhou, Z. Y., Zhu, J. Y., Zhu, K., Zhu, R. D., Zhu, R. L., Zhu, S. H., Zhu, Y. C., Zhu, Z. A., Zhukova, V., Zhulanov, V., Zou, B. S., and Zuo, Y. B.
Subjects: High Energy Physics - Experiment, High Energy Physics - Phenomenology, Physics - Instrumentation and Detectors
Abstract: The Super $\tau$-Charm facility (STCF) is an electron-positron collider proposed by the Chinese particle physics community. It is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of $0.5\times 10^{35}{\rm cm}^{-2}{\rm s}^{-1}$ or higher. The STCF will produce a data sample about a factor of 100 larger than that by the present $\tau$-Charm factory -- the BEPCII, providing a unique platform for exploring the asymmetry of matter-antimatter (charge-parity violation), in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions, as well as searching for exotic hadrons and physics beyond the Standard Model. The STCF project in China is under development with an extensive R\&D program. This document presents the physics opportunities at the STCF, describes conceptual designs of the STCF detector system, and discusses future plans for detector R\&D and physics case studies.
Published: 2023
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19. New Electrocardiographic Score for Predicting the Site of Coronary Artery Occlusion in Inferior Wall Acute Myocardial Infarction

Author: Li Y, Wu L, Zhao R, Gao Y, Bai G, Guo Z, Chen X, Chen Y, Liu T, and Li G
Subjects: electrocardiogram, inferior wall myocardial infarction, percutaneous coronary intervention, right coronary artery., Medicine (General), R5-920
Abstract: Yuqing Li,1,&ast; Lei Wu,1,2,&ast; Rui Zhao,1,2,&ast; Yi Gao,1 Geng Bai,1 Ziqiang Guo,1 Xiaolin Chen,1 Yuanlu Chen,2 Tong Liu,1 Guangping Li1 1Tianjin Key Laboratory of Logic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin, 300211, People’s Republic of China; 2TEDA International Cardiovascular Hospital, Electrophysiological Department, Tianjin, 300457, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Guangping Li, Email tic_tjcardiol@126.comBackground: An electrocardiogram (ECG) was used to determine the type of acute myocardial infarction (MI) and locate the culprit vessel. Inferior wall myocardial infarction (IWMI) patients with the right coronary artery (RCA) as the culprit vessel may have a worse clinical prognosis than the left circumflex artery (LCx). We aimed to develop a new, simple, accurate scoring system to localize the RCA.Methods: From January 2018 to January 2020, patients were admitted to the Department of Cardiology of TEDA International Cardiovascular Hospital and the Second Hospital of Tianjin Medical University due to IWMI and coronary angiography confirmed that the infarct-related vessel was a single RCA or LCx. ECG of patients before percutaneous coronary intervention (PCI) was collected to quantitatively analyze the characteristics of ST-segment deviation in non-inferior wall leads (N-IWL) and establish the RCA score in N-IWL.Results: 149 patients were enrolled, including 83 in the RCA group and 66 in the LCx group. Finally, ST-segment depression (ST↓) lead I, aVR, V1, and V6, and ST↓≥ 1mm in lead V4 were found to be associated with the location of the RCA. The sensitivity, specificity, and area under the curve (AUC) of the N-IWL RCA scoring system were 77.1%, 72.7%, and 0.83, respectively. The diagnostic ability of the scoring system was better than that of other algorithms and scoring systems.Conclusion: ECG helps identify the RCA in patients with IWMI before PCI. The N-IWL RCA score may help identify the culprit vessel as the RCA in patients with IWMI.Keywords: electrocardiogram, inferior wall myocardial infarction, percutaneous coronary intervention, right coronary artery
Published: 2024

20. Fe3O4 Nanoparticles That Modulate the Polarisation of Tumor-Associated Macrophages Synergize with Photothermal Therapy and Immunotherapy (PD-1/PD-L1 Inhibitors) to Enhance Anti-Tumor Therapy

Author: Sun H, Wang X, Guo Z, Hu Z, Yin Y, Duan S, Jia W, Lu W, and Hu J
Subjects: photothermal therapy, immunotherapy, tumor-associated macrophages, head and neck squamous cell carcinoma, Medicine (General), R5-920
Abstract: Haishui Sun,1,&ast; Xiao Wang,2,3,&ast; Zhaoyang Guo,4,&ast; Zhenrong Hu,5 Yuanchen Yin,4 Shuhan Duan,6 Wenwen Jia,2 Wei Lu,2,3 Jingzhou Hu1,7 1Department of Oral and Maxillofacial - Head and Neck Oncology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, People’s Republic of China; 2Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, People’s Republic of China; 3Shanghai Key Laboratory of D&A for Metal Functional Materials, School of Materials Science and Engineering, Tongji University, Shanghai, People’s Republic of China; 4School of Stomatology, Weifang Medical University, Weifang, Shandong Province, People’s Republic of China; 5Department of Stomatology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of China; 6Shanghai Key Laboratory of Stomatology, Department of Oral Surgery, Shanghai Ninth People’s Hospital, College of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Research Institute of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 7Department of Oral and Maxillofacial Surgery, Zhang Zhiyuan Academician Workstation, Hainan Western Central Hospital, Shanghai Ninth People’s Hospital, Danzhou, Hainan, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jingzhou Hu; Wei Lu, Email huyayi@shsmu.edu.cn; weilu@tongji.edu.cnIntroduction: Traditional surgical resection, radiotherapy, and chemotherapy have been the treatment options for patients with head and neck squamous cell carcinoma (HNSCC) over the past few decades. Nevertheless, the five-year survival rate for patients has remained essentially unchanged, and research into treatments has been relatively stagnant. The combined application of photothermal therapy (PTT) and immunotherapy for treating HNSCC has considerable potential.Methods: Live-dead cell staining and CCK-8 assays proved that Fe3O4 nanoparticles are biocompatible in vitro. In vitro, cellular experiments utilized flow cytometry and immunofluorescence staining to verify the effect of Fe3O4 nanoparticles on the polarisation of tumor-associated macrophages. In vivo, animal experiments were conducted to assess the inhibitory effect of Fe3O4 nanoparticles on tumor proliferation under the photothermal effect in conjunction with BMS-1. Tumour tissue sections were stained to observe the effects of apoptosis and the inhibition of tumor cell proliferation. The histological damage to animal organs was analyzed by hematoxylin and eosin (H&E) staining.Results: The stable photothermal properties of Fe3O4 nanoparticles were validated by in vitro cellular and in vivo animal experiments. Fe3O4 photothermal action not only directly triggered immunogenic cell death (ICD) and enhanced the immunogenicity of the tumor microenvironment but also regulated the expression of tumor-associated macrophages (TAMs), up-regulating CD86 and down-regulating CD206 to inhibit tumor growth. The PD-1/PD-L1 inhibitor promoted tumor suppression, and reduced tumor recurrence and metastasis. In vivo studies demonstrated that the photothermal action exhibited a synergistic effect when combined with immunotherapy, resulting in significant suppression of primary tumors and an extension of survival.Conclusion: In this study, we applied Fe3O4 photothermolysis in a biomedical context, combining photothermolysis with immunotherapy, exploring a novel pathway for treating HNSCC and providing a new strategy for effectively treating HNSCC.Keywords: photothermal therapy, immunotherapy, tumor-associated macrophages, head and neck squamous cell carcinoma
Published: 2024

21. The Role of Tenascin-C in Hypertrophic Scar Formation: Insights from Cell and Animal Experiments

Author: Xiang W, Guo Z, Zhang Y, and Xu Y
Subjects: hypertrophic scars, tenascin-c, pi3k-akt signaling pathway, rabbit ear model, hff-1, Dermatology, RL1-803
Abstract: Wei Xiang, Zhen Guo, Yiming Zhang, Yuanzhi Xu Department of Stomatology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of ChinaCorrespondence: Yuanzhi Xu; Yiming Zhang, Email amyxyz01@Hotmail.com; 1701086@tongji.edu.cnBackground: Hypertrophic scars (HS) are dermal diseases characterized by excessive fibroblast proliferation and collagen deposition following burns or trauma. While Tenascin-C (TNC)’s role in promoting visceral fibrosis has been established, its impact on skin tissue fibrosis remains unclear. This study aims to investigate the effects of TNC on HS.Methods: RNA sequence and IHC techniques were used to examine the upregulation of TNC gene in human hypertrophic scar tissue compared to normal tissues. Knockdown of TNC in Human skin fibroblasts (HFF-1) cells was achieved, and expression of Col1 and Col3 was evaluated using qPCR. Sirius red collagen staining assessed impact on total collagen content and ECM deposition. Effects on cell proliferation and migration were investigated through cck-8 and cell scratch experiments. Lentivirus infection was used to knock out TNC, and resulting samples were injected into ear wound of rabbits. Effects of TNC knockout on ear scar formation were measured using digital morphology, ultrasound, SEI, H&E, and Masson trichrome methods.Results: Cell experiments: downregulation of TNC decreased Col1 and Col3 expression, leading to reduced collagen production and extracellular matrix deposition. It did not affect HFF-1 cell proliferation and migration. Animal experiments: TNC knockdown promoted wound healing and reduced collagen deposition in rabbit ears.Conclusion: This study suggests that knocking down TNC inhibits collagen formation and extracellular matrix deposition, thereby inhibiting hypertrophic scar formation. Therefore, TNC can be considered a potential biomarker for HS formation and may offer promising treatment strategies for clinical management of hypertrophic scars.Keywords: Tenascin-C, hypertrophic scars, rabbit ear scar model, HFF-1
Published: 2024

22. The Potential Value of Mean Platelet Volume and Platelet Distribution Width as Inflammatory Indicators in Surgical Necrotizing Enterocolitis

Author: Zhang Y, Chen Y, Lv J, Xiang X, Wang P, Feng W, and Guo Z
Subjects: mean platelet volume, platelet distribution width, necrotizing enterocolitis, neonatal, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract: Yunhan Zhang,1,&ast; Yuyun Chen,2,&ast; Jilin Lv,1 Xiao Xiang,1 Peiyao Wang,1 Wei Feng,1 Zhenhua Guo1 1Department of Neonatal Surgery, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development, Chongqing Key Laboratory of Structural Birth Defect and Reconstruction, Chongqing, People’s Republic of China; 2Fujian Children’s Hospital, Fujian Branch of Shanghai Children’s Medical Center, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, People’s Republic of China&ast;These authors have contributed equally to this workCorrespondence: Zhenhua Guo, Department of neonatal surgery, Children’s Hospital of Chongqing Medical University, 20 Jinyu Road, Yubei District, Chongqing, 400025, People’s Republic of China, Tel +86-23-68370286, Email zhguo@cqmu.edu.cnBackground: This study aims to investigate the potential significance of mean platelet volume (MPV) and platelet distribution width (PDW) in predicting surgical neonatal necrotizing enterocolitis (NEC) and establish the correlation between MPV/PDW levels and the severity/prognosis of NEC.Methods: A retrospective study was conducted on a cohort of 372 patients diagnosed with NEC. The patients were categorized into two groups based on whether they underwent surgical therapy. Univariate /multivariate analysis were employed to compare the MPV and PDW between the two groups. Moreover, patients in surgical group were categorized into multiple subgroups based on intraoperative findings and postoperative prognosis, and the levels of MPV and PDW were compared among these subgroups.Results: Of the 372 patients, the operative group exhibited significantly higher levels of MPV and PDW than the nonoperative group (P < 0.05). Logistic regression analysis revealed that MPV (OR = 4.895, P < 0.001) and PDW (OR = 1.476, P < 0.001) independently associated with surgical NEC. The analysis of the receiver operating characteristic (ROC) curve revealed that the area under the curve (AUC) was 0.706 for MPV alone, with a cut-off value of 11.8 fL. Similarly, the AUC was 0.728 for PDW alone, with a cut-off value of 16%. However, when MPV and PDW were combined, the AUC increased to 0.906 for predicting surgical NEC. In accordance with the intraoperative findings, the levels of MPV and PDW were found to be higher in the large area necrosis group than in the partial or mild necrosis group (P < 0.01). Furthermore, the MPV and PDW values in the death group were significantly greater than those in the survival group (P =0.040, P =0.008).Conclusion: MPV and PDW may serve as potentially valuable indicators for determining the need for surgical intervention and predicting the prognosis of patients with NEC.Keywords: mean platelet volume, platelet distribution width, necrotizing enterocolitis, neonatal
Published: 2024

23. Sivelestat Inhibits Vascular Endothelial Injury Induced by Inflammatory Response and Improves the Prognosis of Hemorrhagic Fever with Renal Syndrome in Children: An Ambispective Cohort Study

Author: Yi W, Wang W, Zhang H, Wang Y, Zhou Y, Guo Z, Li J, Ma L, Yao D, Zhang T, Du Y, and Liu L
Subjects: sivelestat, hemorrhagic fever with renal syndrome, vascular endothelial injury, inflammatory response, cohort study, children, Medicine (General), R5-920
Abstract: Wang Yi,1,2 Weikai Wang,3 Hua Zhang,2 Ying Wang,2 Yong Zhou,2 Zhangyan Guo,2 Jingmei Li,2 Le Ma,2 Dan Yao,2 Taining Zhang,3 Yanqiang Du,2 Li Liu1 1Department of Neonatology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 2Pediatric Intensive Care Unit, the Affiliated Children’s Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 3Pediatric intensive care unit, Gansu Provincial Maternity and Child Health Hospital, Gansu Provincial Central Hospital, Lanzhou, Gansu, People’s Republic of ChinaCorrespondence: Li Liu, Department of Neonatology, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277 Yanta West Road, Yanta District, Xi’an, Shaanxi, 710003, People’s Republic of China, Email liuli918@sohu.com Yanqiang Du, Department of pediatric intensive care unit, the Affiliated Children’s Hospital of Xi’an Jiaotong University, No. 69, Xiju Lane, Lianhu District, Xi’an, Shaanxi, 710003, People’s Republic of China, Email duyanqiang_xaetyy@163.comBackground: In Asia, Hanta virus (HTNV) results in severe hemorrhagic fever with renal syndrome (HFRS). The efficacy of sivelestat in treating children with HTNV-induced HFRS remains unclear.Methods: An ambispective cohort study was performed on children diagnosed with HFRS and hospitalized at the Children’s Hospital Affiliated to Xi’an Jiaotong University from August 2018 to 2023. Patients who received neutrophil elastin-inhibitor infusion between August 2019 and August 2023 were assigned to the sivelestat group, while patients who did not were assigned to the control group. The independent sample t test was used for inter-group analysis. The Chi-square test and Fisher’s exact probability test were used for categorical variables. Spearman correlation test was used to evaluate the correlation between two sets of continuous variables. Kaplan-Meier survival curve and Log -Rank test was used to evaluate the difference in cumulative probability of survival between the two groups.Results: No significant differences were observed between the two groups in gender, age, contact history, body mass index, HFRS severity, clinical indexes at admission. Compared to the control group, the sivelestat group exhibited a significant decrease in the interleukin-8 level at 48 h (28.5± 3 vs 34.5± 3.5) and 72 h (21.3± 4.5 vs 31.5± 5.6) (P< 0.05), as well as the ICAM-1 level at 48 h (553± 122 vs 784± 187) and 72 h (452± 130 vs 623± 85) (P< 0.05). The concentration of VCAM-1 in the sivelestat group exhibited a consistent downward trend. Moreover, the level of VCAM-1 was significantly lower than that in the control group at 24 h (1760± 289 vs 2180± 445), 48 h (1450± 441 vs 1890± 267), and 72 h (1149± 338 vs 1500± 396) (P< 0.05). Kaplan-Meier curve analysis revealed a statistically significant difference in the cumulative probability of survival between two groups (P = 0.041). In the secondary outcomes, the sivelestat group demonstrated a decrease in the utilization rate of mechanical ventilation and continuous renal replacement therapy (CRRT).Conclusion: Sivelestat may suppress neutrophil-mediated inflammatory response to reduce endothelial and organ damage, and improve clinical outcomes in children with severe hemorrhagic fever and renal syndrome.Keywords: Sivelestat, hemorrhagic fever with renal syndrome, vascular endothelial injury, inflammatory response, cohort study, children
Published: 2024

24. Charged-current non-standard neutrino interactions at Daya Bay

Author: An, F. P., Bai, W. D., Balantekin, A. B., Bishai, M., Blyth, S., Cao, G. F., Cao, J., Chang, J. F., Chang, Y., Chen, H. S., Chen, H. Y., Chen, S. M., Chen, Y., Chen, Y. X., Chen, Z. Y., Cheng, J., Cheng, Y.-C., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Dalager, O., Deng, F. S., Ding, X. Y., Ding, Y. Y., Diwan, M. V., Dohnal, T., Dolzhikov, D., Dove, J., Dugas, K. V., Duyang, H. Y., Dwyer, D. A., Gallo, J. P., Gonchar, M., Gong, G. H., Gong, H., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Han, Y., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, J. H., Huang, X. T., Huang, Y. B., Huber, P., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Langford, T. J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, H. L., Li, J. J., Li, Q. J., Li, R. H., Li, S., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Liu, J. X., Lu, C., Lu, H. Q., Luk, K. B., Ma, B. Z., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mandujano, R. C., Marshall, C., McDonald, K. T., McKeown, R. D., Meng, Y., Napolitano, J., Naumov, D., Naumova, E., Nguyen, T. M. T., Ochoa-Ricoux, J. P., Olshevskiy, A., Park, J., Patton, S., Peng, J. C., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Morales Reveco, C., Rosero, R., Roskovec, B., Ruan, X. C., Russell, B., Steiner, H., Sun, J. L., Tmej, T., Tse, W.-H., Tull, C. E., Tung, Y. C., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z., Wang, Z. M., Wei, H. Y., Wei, L. H., Wei, W., Wen, L. J., Whisnant, K., White, C. G., Wong, H. L. H., Worcester, E., Wu, D. R., Wu, Q., Wu, W. J., Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, H. K., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zavadskyi, V., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. L., Zhang, J. W., Zhang, Q. M., Zhang, S. Q., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, R. Z., Zhou, L., Zhuang, H. L., and Zou, J. H.
Published: 2024
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25. Improved Measurement of the Evolution of the Reactor Antineutrino Flux and Spectrum at Daya Bay

Author: An, FP, Bai, WD, Balantekin, AB, Bishai, M, Blyth, S, Cao, GF, Cao, J, Chang, JF, Chang, Y, Chen, HS, Chen, HY, Chen, SM, Chen, Y, Chen, YX, Cheng, J, Cheng, Y-C, Cheng, ZK, Cherwinka, JJ, Chu, MC, Cummings, JP, Dalager, O, Deng, FS, Ding, YY, Diwan, MV, Dohnal, T, Dolzhikov, D, Dove, J, Dugas, KV, Duyang, HY, Dwyer, DA, Gallo, JP, Gonchar, M, Gong, GH, Gong, H, Gu, WQ, Guo, JY, Guo, L, Guo, XH, Guo, YH, Guo, Z, Hackenburg, RW, Han, Y, Hans, S, He, M, Heeger, KM, Heng, YK, Hor, YK, Hsiung, YB, Hu, BZ, Hu, JR, Hu, T, Hu, ZJ, Huang, HX, Huang, JH, Huang, XT, Huang, YB, Huber, P, Jaffe, DE, Jen, KL, Ji, XL, Ji, XP, Johnson, RA, Jones, D, Kang, L, Kettell, SH, Kohn, S, Kramer, M, Langford, TJ, Lee, J, Lee, JHC, Lei, RT, Leitner, R, Leung, JKC, Li, F, Li, HL, Li, JJ, Li, QJ, Li, RH, Li, S, Li, SC, Li, WD, Li, XN, Li, XQ, Li, YF, Li, ZB, Liang, H, Lin, CJ, Lin, GL, Lin, S, Ling, JJ, Link, JM, Littenberg, L, Littlejohn, BR, Liu, JC, Liu, JL, Liu, JX, Lu, C, Lu, HQ, and Luk, KB
Subjects: Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, Nuclear Reactors, Uranium, Daya Bay Collaboration, Mathematical Sciences, Engineering, General Physics, Mathematical sciences, Physical sciences
Abstract: Reactor neutrino experiments play a crucial role in advancing our knowledge of neutrinos. In this Letter, the evolution of the flux and spectrum as a function of the reactor isotopic content is reported in terms of the inverse-beta-decay yield at Daya Bay with 1958 days of data and improved systematic uncertainties. These measurements are compared with two signature model predictions: the Huber-Mueller model based on the conversion method and the SM2018 model based on the summation method. The measured average flux and spectrum, as well as the flux evolution with the ^{239}Pu isotopic fraction, are inconsistent with the predictions of the Huber-Mueller model. In contrast, the SM2018 model is shown to agree with the average flux and its evolution but fails to describe the energy spectrum. Altering the predicted inverse-beta-decay spectrum from ^{239}Pu fission does not improve the agreement with the measurement for either model. The models can be brought into better agreement with the measurements if either the predicted spectrum due to ^{235}U fission is changed or the predicted ^{235}U, ^{238}U, ^{239}Pu, and ^{241}Pu spectra are changed in equal measure.
Published: 2023

26. A Domain-Knowledge-Inspired Music Embedding Space and a Novel Attention Mechanism for Symbolic Music Modeling

Author: Guo, Z., Kang, J., and Herremans, D.
Subjects: Computer Science - Sound, Computer Science - Artificial Intelligence, Electrical Engineering and Systems Science - Audio and Speech Processing, Electrical Engineering and Systems Science - Signal Processing
Abstract: Following the success of the transformer architecture in the natural language domain, transformer-like architectures have been widely applied to the domain of symbolic music recently. Symbolic music and text, however, are two different modalities. Symbolic music contains multiple attributes, both absolute attributes (e.g., pitch) and relative attributes (e.g., pitch interval). These relative attributes shape human perception of musical motifs. These important relative attributes, however, are mostly ignored in existing symbolic music modeling methods with the main reason being the lack of a musically-meaningful embedding space where both the absolute and relative embeddings of the symbolic music tokens can be efficiently represented. In this paper, we propose the Fundamental Music Embedding (FME) for symbolic music based on a bias-adjusted sinusoidal encoding within which both the absolute and the relative attributes can be embedded and the fundamental musical properties (e.g., translational invariance) are explicitly preserved. Taking advantage of the proposed FME, we further propose a novel attention mechanism based on the relative index, pitch and onset embeddings (RIPO attention) such that the musical domain knowledge can be fully utilized for symbolic music modeling. Experiment results show that our proposed model: RIPO transformer which utilizes FME and RIPO attention outperforms the state-of-the-art transformers (i.e., music transformer, linear transformer) in a melody completion task. Moreover, using the RIPO transformer in a downstream music generation task, we notice that the notorious degeneration phenomenon no longer exists and the music generated by the RIPO transformer outperforms the music generated by state-of-the-art transformer models in both subjective and objective evaluations., Comment: This paper is accepted at AAAI 2023
Published: 2022

27. Precision measurement of reactor antineutrino oscillation at kilometer-scale baselines by Daya Bay

Author: Daya Bay collaboration, An, F. P., Bai, W. D., Balantekin, A. B., Bishai, M., Blyth, S., Cao, G. F., Cao, J., Chang, J. F., Chang, Y., Chen, H. S., Chen, H. Y., Chen, S. M., Chen, Y., Chen, Y. X., Chen, Z. Y., Cheng, J., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Dalager, O., Deng, F. S., Ding, Y. Y., Ding, X. Y., Diwan, M. V., Dohnal, T., Dolzhikov, D., Dove, J., Duyang, H. Y., Dwyer, D. A., Gallo, J. P., Gonchar, M., Gong, G. H., Gong, H., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Han, Y., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, J. H., Huang, X. T., Huang, Y. B., Huber, P., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Langford, T. J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, H. L., Li, J. J., Li, Q. J., Li, R. H., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Liu, J. X., Lu, C., Lu, H. Q., Luk, K. B., Ma, B. Z., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mandujano, R. C., Marshall, C., McDonald, K. T., McKeown, R. D., Meng, Y., Napolitano, J., Naumov, D., Naumova, E., Nguyen, T. M. T., Ochoa-Ricoux, J. P., Olshevskiy, A., Pan, H. -R., Park, J., Patton, S., Peng, J. C., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Reveco, C. Morales, Rosero, R., Roskovec, B., Ruan, X. C., Russell, B., Steiner, H., Sun, J. L., Tmej, T., Treskov, K., Tse, W. -H., Tull, C. E., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y., Wang, Y. F., Wang, Z., Wang, Z. M., Wei, H. Y., Wei, L. H., Wei, W., Wen, L. J., Whisnant, K., White, C. G., Wong, H. L. H., Worcester, E., Wu, D. R., Wu, Q., Wu, W. J., Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, H. K., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zavadskyi, V., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. L., Zhang, J. W., Zhang, Q. M., Zhang, S. Q., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, R. Z., Zhou, L., Zhuang, H. L., and Zou, J. H.
Subjects: High Energy Physics - Experiment
Abstract: We present a new determination of the smallest neutrino mixing angle ${\theta}_{13}$ and the mass-squared difference ${\Delta}{\rm m}^{2}_{32}$ using a final sample of $5.55 \times 10^{6}$ inverse beta-decay (IBD) candidates with the final-state neutron captured on gadolinium. This sample was selected from the complete data set obtained by the Daya Bay reactor neutrino experiment in 3158 days of operation. Compared to the previous Daya Bay results, selection of IBD candidates has been optimized, energy calibration refined, and treatment of backgrounds further improved. The resulting oscillation parameters are ${\rm sin}^{2}2{\theta}_{13} = 0.0851 \pm 0.0024$, ${\Delta}{\rm m}^{2}_{32} = (2.466 \pm 0.060) \times 10^{-3}{\rm eV}^{2}$ for the normal mass ordering or ${\Delta}{\rm m}^{2}_{32} = -(2.571 \pm 0.060) \times 10^{-3} {\rm eV}^{2}$ for the inverted mass ordering., Comment: 7 pages, 3 figures, 1 table, 10 supplementary files
Published: 2022

28. On universal butterfly and antisymmetric magnetoresistances

Author: Wu, H. T., Min, Tai, Guo, Z. X., and Wang, X. R.
Subjects: Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Materials Science
Abstract: Butterfly magnetoresistance (BMR) and antisymmetric magnetoresistance (ASMR) are about a butterfly-cross curve and a curve with one peak and one valley when a magnetic field is swept up and down along a fixed direction. Other than the parallelogram-shaped magnetoresistance-curve (MR-curve) often observed in magnetic memory devices, BMR and ASMR are two ubiquitous types of MR-curves observed in diversified magnetic systems, including van der Waals materials, strongly correlated systems, and traditional magnets. Here, we reveal the general principles and the picture behind the BMR and the ASMR that do not depend on the detailed mechanisms of magnetoresistance: 1) The systems exhibit hysteresis loops, common for most magnetic materials with coercivities. 2) The magnetoresistance of the magnetic structures in a large positive magnetic field and in a large negative magnetic field is approximately the same. With the generalized Ohm's law in magnetic materials, these principles explain why most BMR appears in the longitudinal resistance measurements and is very rare in the Hall resistance measurements. Simple toy models, in which the Landau-Lifshitz-Gilbert equation governs magnetization, are used to demonstrate the principles and explain the appearance and disappearance of BMR in various experiments. Our finding provides a simple picture to understand magnetoresistance-related experiments.
Published: 2022

29. Compositeness and several applications to exotic hadronic states with heavy quarks

Author: Oller, J. A. and Guo, Z. -H.
Subjects: High Energy Physics - Phenomenology, Nuclear Theory
Abstract: Several methods for studying the nature of a resonance are applied to resonances recently discovered in the bottonomium and charmonium sectors. We employ the effective-range expansion, the saturation of the width and compositeness of a resonance, as well as direct fits to data. The latter stem from generic $S$-matrix parameterization that account for relevant dynamical features associated to channels that couple strongly in an energy region around the resonance masses, in which their thresholds also lie. We report on results obtained with these methods for the resonances $Z_b(10610)$, $Z_b(10650)$, $Z_{cs}(3985)$, $Z_c(3900)$, $X(4020)$, $X(6900)$, $X(6825)$, and $P_{cs}(4459)$., Comment: 8 pages, 2 figures, contributed to "XVth Quark Confinement and the Hadron Spectrum Conference" (1-6 August 2022, Stavanger, Norway)
Published: 2022
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30. Precision Measurement of Reactor Antineutrino Oscillation at Kilometer-Scale Baselines by Daya Bay

Author: An, FP, Bai, WD, Balantekin, AB, Bishai, M, Blyth, S, Cao, GF, Cao, J, Chang, JF, Chang, Y, Chen, HS, Chen, HY, Chen, SM, Chen, Y, Chen, YX, Chen, ZY, Cheng, J, Cheng, ZK, Cherwinka, JJ, Chu, MC, Cummings, JP, Dalager, O, Deng, FS, Ding, YY, Ding, XY, Diwan, MV, Dohnal, T, Dolzhikov, D, Dove, J, Duyang, HY, Dwyer, DA, Gallo, JP, Gonchar, M, Gong, GH, Gong, H, Gu, WQ, Guo, JY, Guo, L, Guo, XH, Guo, YH, Guo, Z, Hackenburg, RW, Han, Y, Hans, S, He, M, Heeger, KM, Heng, YK, Hor, YK, Hsiung, YB, Hu, BZ, Hu, JR, Hu, T, Hu, ZJ, Huang, HX, Huang, JH, Huang, XT, Huang, YB, Huber, P, Jaffe, DE, Jen, KL, Ji, XL, Ji, XP, Johnson, RA, Jones, D, Kang, L, Kettell, SH, Kohn, S, Kramer, M, Langford, TJ, Lee, J, Lee, JHC, Lei, RT, Leitner, R, Leung, JKC, Li, F, Li, HL, Li, JJ, Li, QJ, Li, RH, Li, S, Li, SC, Li, WD, Li, XN, Li, XQ, Li, YF, Li, ZB, Liang, H, Lin, CJ, Lin, GL, Lin, S, Ling, JJ, Link, JM, Littenberg, L, Littlejohn, BR, Liu, JC, Liu, JL, Liu, JX, Lu, C, Lu, HQ, Luk, KB, and Z., B
Subjects: Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, Daya Bay Collaboration, Mathematical Sciences, Engineering, General Physics, Mathematical sciences, Physical sciences
Abstract: We present a new determination of the smallest neutrino mixing angle θ_{13} and the mass-squared difference Δm_{32}^{2} using a final sample of 5.55×10^{6} inverse beta-decay (IBD) candidates with the final-state neutron captured on gadolinium. This sample is selected from the complete dataset obtained by the Daya Bay reactor neutrino experiment in 3158 days of operation. Compared to the previous Daya Bay results, selection of IBD candidates has been optimized, energy calibration refined, and treatment of backgrounds further improved. The resulting oscillation parameters are sin^{2}2θ_{13}=0.0851±0.0024, Δm_{32}^{2}=(2.466±0.060)×10^{-3} eV^{2} for the normal mass ordering or Δm_{32}^{2}=-(2.571±0.060)×10^{-3} eV^{2} for the inverted mass ordering.
Published: 2023

31. DENT-DDSP: Data-efficient noisy speech generator using differentiable digital signal processors for explicit distortion modelling and noise-robust speech recognition

Author: Guo, Z., Chen, C., and Chng, E. S.
Subjects: Electrical Engineering and Systems Science - Audio and Speech Processing, Computer Science - Sound
Abstract: The performances of automatic speech recognition (ASR) systems degrade drastically under noisy conditions. Explicit distortion modelling (EDM), as a feature compensation step, is able to enhance ASR systems under such conditions by simulating the in-domain noisy speeches from the clean counterparts. Yet, existing distortion models are either non-trainable or unexplainable and often lack controllability and generalization ability. In this paper, we propose a fully explainable and controllable model: DENT-DDSP to achieve EDM. DENT-DDSP utilizes novel differentiable digital signal processing (DDSP) components and requires only 10 seconds of training data to achieve high fidelity. The experiment shows that the simulated noisy data from DENT-DDSP achieves the highest simulation fidelity compared to other baseline models in terms of multi-scale spectral loss (MSSL). Moreover, to validate whether the data simulated by DENT-DDSP are able to replace the scarce in-domain noisy data in the noise-robust ASR tasks, several downstream ASR models with the same architecture are trained using the simulated data and the real data. The experiment shows that the model trained with the simulated noisy data from DENT-DDSP achieves similar performances to the benchmark with a 2.7\% difference in terms of word error rate (WER). The code of the model is released online.
Published: 2022

32. An Analysis of Tensile and Compressive Properties of Carbon Fiber High-Entropy Alloy Composite Laminates

Author: Guo, Z. X., Shi, H. L., Ma, S. G., Cui, J. J., Chai, G. B., and Li, Y. C.
Published: 2024
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33. Experimental Study on a Water Droplet Impacting on the Heated Glycerol Surface

Author: Jin, S., Zhang, W., Guo, Z., Yuan, Y., Shi, Z., and Yan, J.
Published: 2023
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34. Improved the H2S corrosion resistance for Nb30Hf35Co35 alloy by modifying surface catalytic layer

Author: Yan, Erhu, Li, T. W., Zhang, J. L., Zhang, K. X., Guo, Z. J., Liu, W., Zhang, S., Wang, Y. H., Zou, Y. J., Chu, H. L., Zhang, H. Z., Xu, F., and Sun, Lixian
Published: 2023
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35. New progress of the miniaturized microwave ion source at Peking University

Author: Peng, S. X., Ma, T. H., Wu, W. B., Cui, B. J., Zhang, A. L., Jiang, Y. X., Guo, Z. Y., and Chen, J. E.
Published: 2023
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36. Estimation of the Soluble Salt Concentration in Murals Based on Spectral Transformation and Feature Extraction Modelling

Author: Guo, Z. Q., Lyu, S. Q., and Hou, M. L.
Published: 2023
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37. Network and Experimental Pharmacology on Mechanism of Yixintai Regulates the TMAO/PKC/NF-κB Signaling Pathway in Treating Heart Failure

Author: Wang Z, Liu C, Wei J, Yuan H, Shi M, Zhang F, Zeng Q, Huang A, Du L, Li Y, and Guo Z
Subjects: heart failure, yixintai, tmao, pkc/nf-κb pathway, traditional chinese medicine, network pharmacology, Therapeutics. Pharmacology, RM1-950
Abstract: Ziyan Wang,1,2,&ast; Chengxin Liu,1,2,&ast; Jiaming Wei,2,3 Hui Yuan,1,2 Min Shi,2,3 Fei Zhang,2,3 Qinghua Zeng,2,3 Aisi Huang,2,3 Lixin Du,4 Ya Li,4 Zhihua Guo2,3 1First Clinical College of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, 410208, People’s Republic of China; 2Hunan Key Laboratory of Colleges and Universities of Intelligent Traditional Chinese Medicine Diagnosis and Preventive Treatment of Chronic Diseases of Hunan Universities of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, 410208, People’s Republic of China; 3School of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, 410208, People’s Republic of China; 4School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Ya Li; Zhihua Guo, Email 003872@hnucm.edu.cn; 004294@hnucm.edu.cnObjective: This study aims to explore the mechanism of action of Yixintai in treating chronic ischemic heart failure by combining bioinformatics and experimental validation.Materials and Methods: Five potential drugs for treating heart failure were obtained from Yixintai (YXT) through early mass spectrometry detection. The targets of YXT for treating heart failure were obtained by a search of online databases. Gene ontology (GO) functional enrichment analysis and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analyses were conducted on the common targets using the DAVID database. A rat heart failure model was established by ligating the anterior descending branch of the left coronary artery. A small animal color Doppler ultrasound imaging system detected cardiac function indicators. Hematoxylin-eosin (HE), Masson’s, and electron microscopy were used to observe the pathological morphology of the myocardium in rats with heart failure. The network pharmacology analysis results were validated by ELISA, qPCR, and Western blotting.Results: A total of 107 effective targets were obtained by combining compound targets and eliminating duplicate values. PPI analysis showed that inflammation-related proteins (TNF and IL1B) were key targets for treating heart failure, and KEGG enrichment suggested that NF-κB signaling pathway was a key pathway for YXT treatment of heart failure. Animal model validation results indicated the following: YXT can significantly reduce the content of intestinal microbiota metabolites such as trimethylamine oxide (TMAO) and improve heart failure by improving the EF and FS values of heart ultrasound in rats and reducing the levels of serum NT-proBNP, ANP, and BNP to improve heart failure. Together, YXT can inhibit cardiac muscle hypertrophy and fibrosis in rats and improve myocardial ultrastructure and serum IL-1β, IL-6, and TNF-α levels. These effects are achieved by inhibiting the expressions of NF-κB and PKC.Conclusion: YXT regulates the TMAO/PKC/NF-κB signaling pathway in heart failure.Keywords: heart failure, yixintai, TMAO, PKC/NF-κB pathway, traditional Chinese medicine, network pharmacology
Published: 2024

38. Dynasore Alleviates LPS-Induced Acute Lung Injury by Inhibiting NLRP3 Inflammasome-Mediated Pyroptosis

Author: Shan M, Wan H, Ran L, Ye J, Xie W, Lu J, Hu X, Deng S, Zhang W, Chen M, Wang F, and Guo Z
Subjects: acute lung injury, acute respiratory distress syndrome, nlrp3 inflammasome, pyroptosis, dynasore, inflammation., Therapeutics. Pharmacology, RM1-950
Abstract: Mengtian Shan,1 Huimin Wan,1 Linyu Ran,1 Jihui Ye,1 Wang Xie,2 Jingjing Lu,1 Xueping Hu,1 Shengjie Deng,1 Wenyu Zhang,1 Miao Chen,3 Feilong Wang,1 Zhongliang Guo1,4 1Department of Pulmonary and Critical Care Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of China; 2Department of Respiratory Medicine, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China; 3Department of Emergency, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan, People’s Republic of China; 4Department of Respiratory Medicine, Ji’an Hospital, Shanghai East Hospital, Shanghai, Jiangxi, People’s Republic of ChinaCorrespondence: Zhongliang Guo; Feilong Wang, Shanghai East Hospital, School of Medicine, Tongji University, 150st Jimo Road, Pudong, Shanghai, 200092, People’s Republic of China, Tel +86-21-38804518, Fax +86-21-20334513, Email drguozhl@163.com; wang_feilong@tongji.edu.cnBackground: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are clinically severe respiratory disorders without available pharmacological therapies. Dynasore is a cell-permeable molecule that inhibits GTPase activity and exerts protective effects in several disease models. However, whether dynasore can alleviate lipopolysaccharide (LPS)-induced ALI is unknown. This study investigated the effect of dynasore on macrophage activation and explored its potential mechanisms in LPS-induced ALI in vitro and in vivo.Methods: Bone marrow-derived macrophages (BMDMs) were activated classically with LPS or subjected to NLRP3 inflammasome activation with LPS+ATP. A mouse ALI model was established by the intratracheal instillation (i.t.) of LPS. The expression of PYD domains-containing protein 3 (NLRP3), caspase-1, and gasdermin D (GSDMD) protein was detected by Western blots. Inflammatory mediators were analyzed in the cell supernatant, in serum and bronchoalveolar lavage fluid (BALF) by enzyme-linked immunosorbent assays. Morphological changes in lung tissues were evaluated by hematoxylin and eosin staining. F4/80, Caspase-1 and GSDMD distribution in lung tissue was detected by immunofluorescence.Results: Dynasore downregulated nuclear factor (NF)-κB signaling and reduced proinflammatory cytokine production in vitro and inhibited the production and release of interleukin (IL)-1β, NLRP3 inflammasome activation, and macrophage pyroptosis through the Drp1/ROS/NLRP3 axis. Dynasore significantly reduced lung injury scores and proinflammatory cytokine levels in both BALF and serum in vivo, including IL-1β and IL-6. Dynasore also downregulated the co-expression of F4/80, caspase-1 and GSDMD in lung tissue.Conclusion: Collectively, these findings demonstrated that dynasore could alleviate LPS-induced ALI by regulating macrophage pyroptosis, which might provide a new therapeutic strategy for ALI/ARDS.Keywords: acute lung injury, acute respiratory distress syndrome, NLRP3 inflammasome, pyroptosis, dynasore, inflammation
Published: 2024

39. Correlation Analysis of IL-17, IL-21, IL-23 with Non-Alcoholic Liver Fibrosis and Cirrhosis

Author: Yang X, Liao L, Liang Z, Yu S, and Guo Z
Subjects: non-alcoholic liver fibrosis, cirrhosis, diagnostic markers, cytokines, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract: Xiaoyan Yang,1 Liyin Liao,1 Zizhen Liang,1 Shenglong Yu,2 Zhonghui Guo1 1Department of Laboratory Medicine, The Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou, 511400, People’s Republic of China; 2Institute of Cardiovascular Medicine, The Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou, 511400, People’s Republic of ChinaCorrespondence: Zhonghui Guo, Department of Laboratory Medicine, The Affiliated Panyu Central Hospital of Guangzhou Medical University, No. 8, Fuyu East Road, Qiaonan Street, Panyu District, Guangzhou, 511400, People’s Republic of China, Tel +86 20 3485 8850, Email Guo_zhonghui23@163.comObjective: This research aimed to explore the involvement of interleukins (IL) - IL-6, IL-17, IL-21, and IL-23 - in the evolution and diagnosis of non-alcoholic liver fibrosis and cirrhosis.Methods: The study subjects were selected from the patients who visited the Department of Hepatology of X Hospital in Y City from August 2021 to April 2023. Peripheral blood samples were collected. All participants were divided into liver fibrosis, cirrhosis, hepatitis, and healthy subjects four groups. IL-21, IL-17, IL23, IL-6 were detected by double antibody sandwich.Results: The results showed that there was a significant difference in the levels of IL-17, IL-21, and IL-23 among the 4 groups (P< 0.0001). ROC curve analysis showed that the AUC values of IL-17, IL-21 and liver fiber 4 items were > 0.70, suggesting that the diagnostic efficacy of IL-17, IL-21 was similar to that of liver fiber 4 items. Spearman correlation analysis showed that IL-17 had a positive correlation with collagen type III N-peptide, type IV collagen, and Laminin (P < 0.05), and no correlation with Hyaluronic acid (P > 0.05).Conclusion: IL-17, IL-21, and IL-23 play a pivotal role in the inflammatory pathways associated with liver injuries, establishing themselves as potent auxiliary diagnostic markers in identifying liver fibrosis and cirrhosis.Keywords: non-alcoholic liver fibrosis, cirrhosis, diagnostic markers, cytokines
Published: 2024

40. Immune-Related Adverse Event-Related Adrenal Insufficiency Mediates Immune Checkpoint Inhibitors Efficacy in Cancer Treatment

Author: Zhang S, Wu J, Zhao Y, Zhang J, Zhang X, Wu C, Zhang Z, and Guo Z
Subjects: endocrine adverse event, malignancies, monoclonal antibody therapy, immune-related side effects, treatment efficacy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Shasha Zhang,1,&ast; Jianhua Wu,2,&ast; Yue Zhao,3 Jingjing Zhang,1 Xiaoyun Zhang,1 Chensi Wu,3 Zhidong Zhang,4 Zhanjun Guo1 1Department of Immunology and Rheumatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, People’s Republic of China; 2Animal Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, People’s Republic of China; 3Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, People’s Republic of China; 4Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zhidong Zhang, Department of Surgery, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang, 050011, People’s Republic of China, Email zzd407@163.com Zhanjun Guo, Department of Immunology and Rheumatology, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang, 050011, People’s Republic of China, Tel +86 311 86095734, Email zjguo5886@aliyun.comPurpose: Immune checkpoint inhibitors (ICIs) have significantly improved the outcomes of patients with cancer; however, these agents may initiate immune-related adverse events (irAEs). Previous studies have demonstrated a robust correlation between disease prognosis and the occurrence of irAEs, specifically skin or endocrine irAEs. Herein, we aimed to evaluate the correlation between irAE-related adrenal insufficiency (AI) and ICI treatment efficacy.Patients and methods: Patients diagnosed with gastrointestinal, respiratory, head and neck, urological, skin and gynecologic cancers treated with anti-programmed cell death 1 (PD-1)/anti-programmed cell death ligand 1 (PD-L1) antibody as monotherapy or combined therapy (combined with chemotherapy or targeted therapy) were divided into irAE-A (patients with irAE-related AI), irAE-B (patients with other irAEs) and non-irAE groups. Immunotherapy efficacy was assessed based on the disease control rate (DCR), progression-free survival (PFS), and overall survival (OS). Survival probabilities were estimated using the Kaplan–Meier method with the log–rank test.Results: Of the 192 patients enrolled in our study, 17 developed irAE-related AI and 83 developed other irAEs. The DCR of the irAE-A and irAE-B groups were higher than that of the non-irAE group (P< 0.05). Multiple extended Cox regression analyses showed that irAE status (irAE-A vs non-irAE, P=0.008; irAE-B vs non-irAE, P=0.020), Eastern Cooperative Oncology Group (ECOG) status (P=0.045), tumor-node-metastasis (TNM) stage (P=0.000), and treatment line (P=0.002) were independent predictors of PFS. Contrarily, irAE status (irAE-A vs non-irAE, P=0.009; irAE-B vs non-irAE, P=0.013), ECOG status (P=0.007), TNM stage (P=0.035), treatment line (P=0.001) and treatment modality (P=0.008) were independent predictors for OS.Conclusion: IrAE-related AI was significantly associated with ICI treatment efficacy in patients with cancer, which could be a potentially predictable marker. Due to the destruction of adrenal tissue by T cells with enhanced activity, AI reflects enhanced T cell activity to some extent.Keywords: endocrine adverse event, malignancies, monoclonal antibody therapy, immune-related side effects, treatment efficacy
Published: 2024

41. Evaluation of the Correlation Between Distribution Location and Vulnerability of Carotid Plaque in Patients with Transient Ischemic Attack

Author: Zhao Y, Gu Y, Liu Y, and Guo Z
Subjects: carotid artery, plaque morphology, plaque vulnerability, atherosclerosis, plaque distribution, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Yinan Zhao,1 Yan Gu,2 Ying Liu,3 Zhongping Guo4 1Department of Radiology, The Affiliated Jinzhou Medical University, Jinzhou, People’s Republic of China; 2Department of Radiology, The Affiliated First People’s Hospital of Lianyungang, Lianyungang, People’s Republic of China; 3Department of Radiology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, People’s Republic of China; 4Department of Radiology, The Affiliated Lianyungang Clinical College of Nanjing Medical University, Lianyungang, People’s Republic of ChinaCorrespondence: Yan Gu, Department of Radiology, Lianyungang First People’s Hospital, 1st Floor, Building 2, Gaoxin District, No. 6 East Zhenhua Road, Haizhou District, Lianyungang, Jiangsu Province, People’s Republic of China, Tel +86 18961327326, Email 13815617997@139.comPurpose: To analyze the relationship among distribution location, characteristics, and vulnerability of carotid plaque using CTA and provide more information on the risk factors of carotid atherosclerotic plaque.Patients and Methods: We retrospectively analyzed the CTA images of the head and neck of 93 patients with carotid atherosclerosis. Atherosclerosis was developed in 148 carotid arteries. The plaques were divided into a high-risk plaque group and a low-risk plaque group according to whether the plaques had high-risk characteristics. The maximum cross-sectional area of carotid artery bifurcation plaque on the axial image was selected, and the cross-sectional lumen was equally divided into four 90-degree sectors, ventral side wall, dorsal side wall, inner side wall, and outer side wall. The differences in the characteristics and distribution locations of the plaques in the two groups were analyzed. The characteristic parameters of the cross-sectional plaques at the bifurcation of the carotid artery. The logistic regression analysis was used to further analyze the risk factors associated with plaque vulnerability.Results: Among 148 carotid arteries,80 were classified as high-risk and 68 as low-risk groups. There were significant differences between the two groups concerning the thickness, length, maximum cross-sectional area, burden, and cross-sectional distribution of the plaques (P < 0.05). The plaque distribution on the dorsal side wall of the carotid bifurcation was higher in the high-risk group than that in the low-risk group (P < 0.05), dorsal side wall plaque-independent risk factors for the development of vulnerability of plaques in transient ischemic attack (TIA) patients (95% CI:1.522~6.991, P< 0.05).Conclusion: High-risk plaques tend to occur on the dorsal side wall of the carotid bifurcation, whereas low-risk plaques tend to occur on the outer side wall of the carotid bifurcation.Keywords: carotid artery, plaque morphology, plaque vulnerability, atherosclerosis, plaque distribution
Published: 2024

42. Lifestyle Influence on Mild Cognitive Impairment Progression: A Decision Tree Prediction Model Study

Author: Hou J, Jiang H, Han Y, Huang R, Gao X, Feng W, and Guo Z
Subjects: lifestyle, mild cognitive impairment progression, survival analysis, decision tree prediction model, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract: Jiwen Hou,1,2,&ast; Hua Jiang,1,&ast; Yan Han,1 Rong Huang,1 Xiang Gao,1 Wei Feng,1 Zongjun Guo2 1Department of Geriatrics, Affiliated Hospital of Chengdu University, Chengdu, People’s Republic of China; 2Department of Geriatrics, Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zongjun Guo, Department of Geriatrics, Affiliated Hospital of Qingdao University, No. 16, Jiangsu Road, Qingdao, Shandong Province, People’s Republic of China, Tel +8618661808736, Email guozjj@163.comPurpose: This study assessed the influences of different lifestyle on mild cognitive impairment (MCI) progression and established a decision tree prediction model to analyse their predictive significance on MCI progression incidence.Patients and Methods: From October 2015 to February 2020,330 patients with MCI were recruited, and demographic and lifestyle information collected. They were followed up for 19.04 ± 10.227 months. Cognitive function was assessed using the Mini-Mental State Examination Scale every 6 months, and they were divided into MCI stable group and MCI progression group.Results: The Kaplan Meier survival analysis showed an overall cohort survival rate of 33.2%; the annual conversion rate of MCI progression was 20%. Physical exercise, social engagement, high-fat diet, age, napping, and tea drinking were decision tree prediction model nodes. Hobbies were the most important factor for predicting MCI progression. The MCI progression probability rates were: with hobbies 26.829% (44 cases), without hobbies 57.831% (96 cases); for those withot hobbies, with physical exercise 43.077% (28 cases) without physical exercise 72.340% (68 cases); for those without hobbies with physical exercise and social engagement 20.000% (4 cases), without social engagement 53.333% (24 cases); for those without hobbies, physical exercises and social engagement and with nap habits 48.485% (16 cases), without nap habits 66.667% (8 cases). The decision tree prediction model AUC for predicting the MCI progression receiver operating characteristic curve was 0.737 (95% confidence interval: 0.685– 0.785) (75.71% sensitivity, 71.75% specificity, P < 0.001.Conclusion: Hobbies, physical exercise, social engagement, napping, and drinking tea can help prevent MCI progression, while a high-fat diet may exacerbate MCI progression. In this study the rule with the lowest MCI progress probability for those who had hobbies, high-fat diet, and social engagement. And the decision tree model had good prediction efficiency.Keywords: lifestyle, mild cognitive impairment progression, survival analysis, decision tree prediction model
Published: 2024

43. Prediction of Response to Chemoradiotherapy by Dynamic Changes of Circulating Exosome Levels in Patients with Esophageal Squamous Cell Carcinoma

Author: Zhang C, Guo Z, and Jing Z
Subjects: exosomes, exodus platform, locally advanced escc, chemoradiotherapy, Medicine (General), R5-920
Abstract: Chuanfeng Zhang, Zhen Guo, Zhao Jing Department of Oncology, Zhejiang Hospital, Hangzhou, Zhejiang, 310013, People’s Republic of ChinaCorrespondence: Zhao Jing, Department of Oncology, Zhejiang Hospital, No. 12 Lingyin Road, Hangzhou, Zhejiang, 310013, People’s Republic of China, Tel +86-571-87377308, Email jz96329@163.comBackground: The exosomes‐based liquid biopsy represents a prospective biomarker for tumor screening, prognosis prediction, and tumor regression. This study aimed to isolate circulating exosomes (CEs) from plasma of the esophageal squamous cell carcinoma (ESCC) patients who received chemoradiotherapy through exosome detection method via the ultrafast-isolation system (EXODUS) and investigated the association between the dynamic changes of CE levels and therapeutic effect.Methods: We isolated and quantitatively analyzed CEs from plasma of locally advanced ESCC patients received chemoradiotherapy at 2 time points: baseline (pre-chemoradiotherapy) and 2 months after the chemoradiotherapy (post-chemoradiotherapy). We isolated exosomes from plasma by EXODUS platform and confirmed them through nanoparticle tracking analysis (NTA), transmission electron microscope (TEM), and Western blot. The associations of CE level with clinicopathological characteristics, tumor regression, and progression-free survival (PFS) were analyzed.Results: The average diameter of CEs was 107.4± 14.3 nm at baseline and 101.7± 17.1 nm at post-chemoradiotherapy. The mean exosome concentration significantly decreased after chemoradiotherapy (7.3× 1011 particles/mL vs 5.4× 1011 particles/mL, P < 0.001). The patients with stage III–IVA and tumor length ≥ 5cm had obviously higher baseline CE levels. Dynamic changes in CE levels were successfully applied for evaluation of chemoradiotherapy response and PFS. Furthermore, through multivariate Cox regression analysis, it was revealed that dynamic changes of CE levels were an independent predictor of PFS in locally advanced ESCC patients who received chemoradiotherapy.Conclusion: Here, we demonstrated EXODUS platform isolated and enriched CEs from plasma of ESCC patients with high-purity and high-yield. The EXODUS platform can facilitate liquid biopsy based on exosomes translation to the clinic. Baseline CE levels can reflect ESCC tumor burden. The dynamic changes of CE levels during chemoradiotherapy allow the prediction of treatment effect and PFS of ESCC patients, requiring further investigations in larger patient cohorts.Keywords: exosomes, EXODUS platform, locally advanced ESCC, chemoradiotherapy
Published: 2024

44. UGPS J194310+183851: an Unusual Optical and X-ray Faint Cataclysmic Variable?

Author: Morris, C., Maccarone, T. J., Lucas, P. W., Strader, J., Britt, C. T., Miller, N., Swihart, S. J., Cooper, W. J., Drew, J. E., and Guo, Z.
Subjects: Astrophysics - Solar and Stellar Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract: The growing number of multi-epoch optical and infrared sky surveys are uncovering unprecedented numbers of new variable stars, of an increasing number of types. The short interval between observations in adjacent near infrared filters in the UKIDSS Galactic Plane Survey (UGPS) allows for the discovery of variability on the timescale of minutes. We report on the nature of one such object, through the use of optical spectroscopy, time-series photometry and targeted X-ray observations. We propose that UGPS J194310.32+183851.8 is a magnetic cataclysmic variable star of novel character, probably featuring a longer than average spin period and an orbital period likely to be shorter than the period gap (i.e. P$_{\text{orb}}$<2 hours). We reason that the star is likely a member of the short period Intermediate-Polar subclass that exist below this period boundary, but with the additional feature that system's SED is fainter and redder than other members of the group., Comment: 9 pages, 9 figures
Published: 2022
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45. STCF conceptual design report (Volume 1): Physics & detector

Author: Achasov, M., Ai, X. C., An, L. P., Aliberti, R., An, Q., Bai, X. Z., Bai, Y., Bakina, O., Barnyakov, A., Blinov, V., Bobrovnikov, V., Bodrov, D., Bogomyagkov, A., Bondar, A., Boyko, I., Bu, Z. H., Cai, F. M., Cai, H., Cao, J. J., Cao, Q. H., Cao, X., Cao, Z., Chang, Q., Chao, K. T., Chen, D. Y., Chen, H., Chen, H. X., Chen, J. F., Chen, K., Chen, L. L., Chen, P., Chen, S. L., Chen, S. M., Chen, S., Chen, S. P., Chen, W., Chen, X., Chen, X. F., Chen, X. R., Chen, Y., Chen, Y. Q., Cheng, H. Y., Cheng, J., Cheng, S., Cheng, T. G., Dai, J. P., Dai, L. Y., Dai, X. C., Dedovich, D., Denig, A., Denisenko, I., Dias, J. M., Ding, D. Z., Dong, L. Y., Dong, W. H., Druzhinin, V., Du, D. S., Du, Y. J., Du, Z. G., Duan, L. M., Epifanov, D., Fan, Y. L., Fang, S. S., Fang, Z. J., Fedotovich, G., Feng, C. Q., Feng, X., Feng, Y. T., Fu, J. L., Gao, J., Gao, Y. N., Ge, P. S., Geng, C. Q., Geng, L. S., Gilman, A., Gong, L., Gong, T., Gou, B., Gradl, W., Gu, J. L., Guevara, A., Gui, L. C., Guo, A. Q., Guo, F. K., Guo, J. C., Guo, J., Guo, Y. P., Guo, Z. H., Guskov, A., Han, K. L., Han, L., Han, M., Hao, X. Q., He, J. B., He, S. Q., He, X. G., He, Y. L., He, Z. B., Heng, Z. X., Hou, B. L., Hou, T. J., Hou, Y. R., Hu, C. Y., Hu, H. M., Hu, K., Hu, R. J., Hu, W. H., Hu, X. H., Hu, Y. C., Hua, J., Huang, G. S., Huang, J. S., Huang, M., Huang, Q. Y., Huang, W. Q., Huang, X. T., Huang, X. J., Huang, Y. B., Huang, Y. S., Hüsken, N., Ivanov, V., Ji, Q. P., Jia, J. J., Jia, S., Jia, Z. K., Jiang, H. B., Jiang, J., Jiang, S. Z., Jiao, J. B., Jiao, Z., Jing, H. J., Kang, X. L., Kang, X. S., Ke, B. C., Kenzie, M., Khoukaz, A., Koop, I., Kravchenko, E., Kuzmin, A., Lei, Y., Levichev, E., Li, C. H., Li, C., Li, D. Y., Li, F., Li, G., Li, G., Li, H. B., Li, H., Li, H. N., Li, H. J., Li, H. L., Li, J. M., Li, J., Li, L., Li, L., Li, L. Y., Li, N., Li, P. R., Li, R. H., Li, S., Li, T., Li, W. J., Li, X., Li, X. H., Li, X. Q., Li, X. H., Li, Y., Li, Y. Y., Li, Z. J., Liang, H., Liang, J. H., Liang, Y. T., Liao, G. R., Liao, L. Z., Liao, Y., Lin, C. X., Lin, D. X., Lin, X. S., Liu, B. J., Liu, C. W., Liu, D., Liu, F., Liu, G. M., Liu, H. B., Liu, J., Liu, J. J., Liu, J. B., Liu, K., Liu, K. Y., Liu, K., Liu, L., Liu, Q., Liu, S. B., Liu, T., Liu, X., Liu, Y. W., Liu, Y., Liu, Y. L., Liu, Z. Q., Liu, Z. Y., Liu, Z. W., Logashenko, I., Long, Y., Lu, C. G., Lu, J. X., Lu, N., Lü, Q. F., Lu, Y., Lu, Y., Lu, Z., Lukin, P., Luo, F. J., Luo, T., Luo, X. F., Lyu, H. J., Lyu, X. R., Ma, J. P., Ma, P., Ma, Y., Ma, Y. M., Maas, F., Malde, S., Matvienko, D., Meng, Z. X., Mitchell, R., Nefediev, A., Nefedov, Y., Olsen, S. L., Ouyang, Q., Pakhlov, P., Pakhlova, G., Pan, X., Pan, Y., Passemar, E., Pei, Y. P., Peng, H. P., Peng, L., Peng, X. Y., Peng, X. J., Peters, K., Pivovarov, S., Pyata, E., Qi, B. B., Qi, Y. Q., Qian, W. B., Qian, Y., Qiao, C. F., Qin, J. J., Qin, J. J., Qin, L. Q., Qin, X. S., Qiu, T. L., Rademacker, J., Redmer, C. F., Sang, H. Y., Saur, M., Shan, W., Shan, X. Y., Shang, L. L., Shao, M., Shekhtman, L., Shen, C. P., Shen, J. M., Shen, Z. T., Shi, H. C., Shi, X. D., Shwartz, B., Sokolov, A., Song, J. J., Song, W. M., Song, Y., Song, Y. X., Sukharev, A., Sun, J. F., Sun, L., Sun, X. M., Sun, Y. J., Sun, Z. P., Tang, J., Tang, S. S., Tang, Z. B., Tian, C. H., Tian, J. S., Tian, Y., Tikhonov, Y., Todyshev, K., Uglov, T., Vorobyev, V., Wan, B. D., Wang, B. L., Wang, B., Wang, D. Y., Wang, G. Y., Wang, G. L., Wang, H. L., Wang, J., Wang, J. H., Wang, J. C., Wang, M. L., Wang, R., Wang, R., Wang, S. B., Wang, W., Wang, W. P., Wang, X. C., Wang, X. D., Wang, X. L., Wang, X. L., Wang, X. P., Wang, X. F., Wang, Y. D., Wang, Y. P., Wang, Y. Q., Wang, Y. L., Wang, Y. G., Wang, Z. Y., Wang, Z. Y., Wang, Z. L., Wang, Z. G., Wei, D. H., Wei, X. L., Wei, X. M., Wen, Q. G., Wen, X. J., Wilkinson, G., Wu, B., Wu, J. J., Wu, L., Wu, P., Wu, T. W., Wu, Y. S., Xia, L., Xiang, T., Xiao, C. W., Xiao, D., Xiao, M., Xie, K. P., Xie, Y. H., Xing, Y., Xing, Z. Z., Xiong, X. N., Xu, F. R., Xu, J., Xu, L. L., Xu, Q. N., Xu, X. C., Xu, X. P., Xu, Y. C., Xu, Y. P., Xu, Y., Xu, Z. Z., Xuan, D. W., Xue, F. F., Yan, L., Yan, M. J., Yan, W. B., Yan, W. C., Yan, X. S., Yang, B. F., Yang, C., Yang, H. J., Yang, H. R., Yang, H. T., Yang, J. F., Yang, S. L., Yang, Y. D., Yang, Y. H., Yang, Y. S., Yang, Y. L., Yang, Z. W., Yang, Z. Y., Yao, D. L., Yin, H., Yin, X. H., Yokozaki, N., You, S. Y., You, Z. Y., Yu, C. X., Yu, F. S., Yu, G. L., Yu, H. L., Yu, J. S., Yu, J. Q., Yuan, L., Yuan, X. B., Yuan, Z. Y., Yue, Y. F., Zeng, M., Zeng, S., Zhang, A. L., Zhang, B. W., Zhang, G. Y., Zhang, G. Q., Zhang, H. J., Zhang, H. B., Zhang, J. Y., Zhang, J. L., Zhang, J., Zhang, L., Zhang, L. M., Zhang, Q. A., Zhang, R., Zhang, S. L., Zhang, T., Zhang, X., Zhang, Y., Zhang, Y. J., Zhang, Y. X., Zhang, Y. T., Zhang, Y. F., Zhang, Y. C., Zhang, Y., Zhang, Y., Zhang, Y. M., Zhang, Y. L., Zhang, Z. H., Zhang, Z. Y., Zhang, Z. Y., Zhao, H. Y., Zhao, J., Zhao, L., Zhao, M. G., Zhao, Q., Zhao, R. G., Zhao, R. P., Zhao, Y. X., Zhao, Z. G., Zhao, Z. X., Zhemchugov, A., Zheng, B., Zheng, L., Zheng, Q. B., Zheng, R., Zheng, Y. H., Zhong, X. H., Zhou, H. J., Zhou, H. Q., Zhou, H., Zhou, S. H., Zhou, X., Zhou, X. K., Zhou, X. P., Zhou, X. R., Zhou, Y. L., Zhou, Y., Zhou, Y. X., Zhou, Z. Y., Zhu, J. Y., Zhu, K., Zhu, R. D., Zhu, R. L., Zhu, S. H., Zhu, Y. C., Zhu, Z. A., Zhukova, V., Zhulanov, V., Zou, B. S., and Zuo, Y. B.
Published: 2024
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46. First measurement of high-energy reactor antineutrinos at Daya Bay

Author: Daya Bay collaboration, An, F. P., Balantekin, A. B., Band, H. R., Bishai, M., Blyth, S., Cao, G. F., Cao, J., Chang, J. F., Chang, Y., Chen, H. S., Chen, S. M., Chen, Y., Chen, Y. X., Cheng, J., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Dalager, O., Deng, F. S., Ding, Y. Y., Diwan, M. V., Dohnal, T., Dove, J., Dvorak, M., Dwyer, D. A., Gallo, J. P., Gonchar, M., Gong, G. H., Gong, H., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Higuera, A., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, X. T., Huang, Y. B., Huber, P., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Langford, T. J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, J. J., Li, Q. J., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Lu, C., Lu, H. Q., Lu, J. S., Luk, K. B., Ma, X. B., Ma, X. Y., Ma, Y. Q., Marshall, C., Caicedo, D. A. Martinez, McDonald, K. T., McKeown, R. D., Meng, Y., Napolitano, J., Naumov, D., Naumova, E., Ochoa-Ricoux, J. P., Olshevskiy, A., Pan, H. -R., Park, J., Patton, S., Peng, J. C., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Reveco, C. Morales, Rosero, R., Roskovec, B., Ruan, X. C., Steiner, H., Sun, J. L., Tmej, T., Treskov, K., Tse, W. -H., Tull, C. E., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y., Wang, Y. F., Wang, Z., Wang, Z. M., Wei, H. Y., Wei, L. H., Wen, L. J., Whisnant, K., White, C. G., Wong, H. L. H., Worcester, E., Wu, D. R., Wu, F. L., Wu, Q., Wu, W. J., Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. W., Zhang, Q. M., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhou, L., Zhuang, H. L., and Zou, J. H.
Subjects: High Energy Physics - Experiment, Nuclear Experiment
Abstract: This Letter reports the first measurement of high-energy reactor antineutrinos at Daya Bay, with nearly 9000 inverse beta decay candidates in the prompt energy region of 8-12~MeV observed over 1958 days of data collection. A multivariate analysis is used to separate 2500 signal events from background statistically. The hypothesis of no reactor antineutrinos with neutrino energy above 10~MeV is rejected with a significance of 6.2 standard deviations. A 29\% antineutrino flux deficit in the prompt energy region of 8-11~MeV is observed compared to a recent model prediction. We provide the unfolded antineutrino spectrum above 7 MeV as a data-based reference for other experiments. This result provides the first direct observation of the production of antineutrinos from several high-$Q_{\beta}$ isotopes in commercial reactors., Comment: 7 pages, 4 figures, accepted by Physical Review Letters
Published: 2022
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47. SiRNF8 Delivered by DNA Framework Nucleic Acid Effectively Sensitizes Chemotherapy in Colon Cancer

Author: Guo Z, Song H, Tian Y, Xu J, Zhang G, Guo Y, Shen R, and Wang D
Subjects: dna framework nucleic acid, rnf8, chemosensitivity, rnai, colorectal cancer, Medicine (General), R5-920
Abstract: Zhao Guo,1,&ast; Haoyun Song,1,&ast; Yingxia Tian,2,&ast; Jie Xu,3 Guokun Zhang,1 Yanan Guo,1 Rong Shen,1 Degui Wang1 1Department of Anatomy and Histology, Lanzhou University School of Basic Medical Sciences, Lanzhou, 730000, People’s Republic of China; 2Department of Internal Medicine, Gansu Provincial Academic Institute for Medical Research, Lanzhou, 730050, People’s Republic of China; 3Cuiying Biomedical Research Center, Lanzhou University Second Hospital, Lanzhou, Gansu, 730030, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Degui Wang; Rong Shen, Department of Anatomy and Histology, Lanzhou University School of Basic Medical Sciences, Lanzhou, 730000, People’s Republic of China, Tel +86 13893609120 ; +86 13909483373, Fax +86 931 8915023, Email wangdegui@lzu.edu.cn; shenr@lzu.edu.cnBackground: The evident side effects and decreased drug sensitivity significantly restrict the use of chemotherapy. However, nanoparticles based on biomaterials are anticipated to address this challenge.Methods: Through bioinformatics analysis and colon cancer samples, we initially investigated the expression level of RNF8 in colon cancer. Next, we constructed nanocarrier for delivering siRNF8 based on DNA tetrahedron (si-Tet), and Doxorubicin (DOX) was further intercalated into the DNA structure (si-DOX-Tet) for combination therapy. Further, the effects and mechanism of RNF8 inhibition on the sensitivity of colon cancer cells to DOX chemotherapy have also been studied.Results: RNF8 expression was increased in colon cancer. Agarose gel electrophoresis, transmission electron microscopy, and size distribution and potential analysis confirmed the successful preparation of the two nanoparticles, with particle sizes of 10.29 and 37.29 nm, respectively. Fluorescence imaging reveals that the carriers can be internalized into colon cancer cells and escape from lysosomes after 12 hours of treatment, effectively delivering siRNF8 and DOX. Importantly, Western blot analysis verified treatment with 50nM si-Tet silenced RNF8 expression by approximately 50% in colon cancer cells, and combined treatment significantly inhibited cell proliferation. Furthermore, the CCK-8 assay demonstrated that si-Tet treatment enhanced the sensitivity of colon cancer cells to the three chemotherapeutic drugs. Significant more DNA damage was detected after treatment with both si-Tet or si-DOX-Tet. Further flow cytometry analysis revealed that si-DOX-Tet treatment led to significantly more apoptosis, approximately 1.6-fold higher than treatment with DOX alone. Mechanistically, inhibiting RNF8 led to decreased ABCG2 expression and DOX efflux, but increased DNA damage, thereby enhancing the chemotherapeutic effect of DOX.Conclusion: We have successfully constructed si-DOX-Tet. By inhibiting the expression of RNF8, it enhances the chemotherapy sensitivity of DOX. Therefore, this tetrahedral FNA nanocarrier offers a new approach for the combined treatment of colon cancer. Keywords: DNA framework nucleic acid, RNF8, chemosensitivity, RNAi, colorectal cancer
Published: 2024

48. Discovering and Validating Cuproptosis-Associated Marker Genes for Accurate Keloid Diagnosis Through Multiple Machine Learning Models

Author: Guo Z, Yu Q, Huang W, Huang F, Chen X, and Wei C
Subjects: machine learning, cuproptosis, keloid, novel biomarker., Dermatology, RL1-803
Abstract: Zicheng Guo,1,2,&ast; Qingli Yu,1,&ast; Wencheng Huang,1 Fengyu Huang,1 Xiurong Chen,1 Chuzhong Wei1,2 1Department of Orthopaedics, Huizhou First Hospital, Huizhou, People’s Republic of China; 2Department of Orthopaedics, Southern Medical University, Guangzhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Chuzhong Wei, Department of Orthopaedics, Southern Medical University, Guangzhou, People’s Republic of China, Email chuzhongwei2023@gmail.comBackground: Keloid is a common condition characterized by abnormal scarring of the skin, affecting a significant number of individuals worldwide.Objective: The occurrence of keloids may be related to the reduction of cell death. Recently, a new cell death mode that relies on copper ions has been discovered. This study aimed to identify novel cuproptosis-related genes that are associated with keloid diagnosis.Methods: We utilized several gene expression datasets, including GSE44270 and GSE145725 as the training group, and GSE7890, GSE92566, and GSE121618 as the testing group. We integrated machine learning models (SVM, RF, GLM, and XGB) to identify 10 cuproptosis-related genes (CRGs) for keloid diagnosis in the training group. The diagnostic capability of the identified CRGs was validated using independent datasets, RT-qPCR, Western blotting, and IHC analysis.Results: Our study successfully categorized keloid samples into two clusters based on the expression of cuproptosis-related genes. Utilizing WGCNA analysis, we identified 110 candidate genes associated with cuproptosis. Subsequent functional enrichment analysis results revealed that these genes may play a regulatory role in cell growth within keloid tissue through the MAPK pathway. By integrating machine learning models, we identified CRGs that can be used for diagnosing keloid. The diagnostic efficacy of CRGs was confirmed using independent datasets, RT-qPCR, Western blotting, and IHC analysis. GSVA analysis indicated that high expression of CRGs influenced the gene set related to ECM receptor interaction.Conclusion: This study identified 10 cuproptosis-related genes that provide insights into the molecular mechanisms underlying keloid development and may have implications for the development of targeted therapies. Keywords: machine learning, cuproptosis, keloid, novel biomarker
Published: 2024

49. Robust Dirac lines against Ge vacancy and possible spin-orbit Dirac points in nonsymmorphic HfGe0.92Te

Author: Chen, L., Zhou, L. Q., Zhou, Y., Liu, C., Guo, Z. N., Gao, S. Y., Fan, W. H., Xu, J. F., Guo, Y. X., Liao, Wang, J. O., Weng, H. M., and Wang, G.
Subjects: Condensed Matter - Materials Science, Condensed Matter - Strongly Correlated Electrons
Abstract: Looking for new materials with Dirac points has been a fascinating subject of research. Here we report the growth, crystal structure, and band structure of HfGe0.92Te single crystals, featuring three different types of Dirac points. HfGe0.92Te crystalizes in a nonsymmorphic tetragonal space group P4/nmm (No. 129), having square Ge-atom plane with vacancies about 8%. Despite the vacancies on Ge site, the Dirac nodal line composed of conventional Dirac points vulnerable to spin-orbit coupling (SOC) is observed using angle-resolved photoemission spectroscopy, accompanied with the robust Dirac line protected by the nonsymmorphic symmetry against both SOC and vacancies. Specially, spin-orbit Dirac points (SDPs) originated from the surface formed under SOC are hinted to exist according to our experiments and calculations. Quasi-two-dimensional (quasi-2D) characters are observed and further confirmed by angular-resolved magnetoresistance. HfGe0.92Te is a good candidate to explore exotic topological phases or topological properties with three different types of Dirac points and a promising candidate to realize 2D SDPs., Comment: 16 pages, 9 figures
Published: 2022
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50. Performance and microbial dynamics of side-stream activated sludge hydrolysis process at different influent food-to-microorganism (F/M) ratios

Author: Guo, Z., Zhang, J., Xu, P., Liu, Y., Jing, X., Liu, L., Zhang, Z., Qin, L., Chai, G., Lv, T., Zheng, X., and Wang, D.
Published: 2023
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