Search

Your search keyword '"Guo, Yiyuan"' showing total 23 results
Start Over Author "Guo, Yiyuan"
23 results on '"Guo, Yiyuan"'

13. Reduced administration frequency for the treatment of fungal keratitis: a sustained natamycin release from a micellar solution

Author

Hong Zhang, Guo Yiyuan, Fatemeh Karimi, Qiang Fu, and Greg G. Qiao

Subjects
Drug, Drug Liberation, Antifungal Agents, Natamycin, media_common.quotation_subject, medicine.medical_treatment, Administration, Topical, Antifungal drug, Pharmaceutical Science, 02 engineering and technology, Pharmacology, 030226 pharmacology & pharmacy, Micelle, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, Humans, Fungal keratitis, Micelles, media_common, Keratitis, Chemistry, Eye drop, Eye infection, 021001 nanoscience & nanotechnology, medicine.disease, Nanoparticles, Rabbits, 1115 Pharmacology and Pharmaceutical Sciences, 0210 nano-technology, Eye Infections, Fungal, medicine.drug
Abstract

Background: Natamycin is the only topical ophthalmic antifungal drug approved by the Food and Drug Administration (FDA) of the United States, but has unsatisfactory factors such as high dosing frequency.Methods: We report the synthesis and preparation of self-assembled poly(ethylene glycol)-block-poly(glycidyl methacrylate) (PEG-b-PGMA) micelles. These nanoparticles exhibit sustained delivery of a hydrophobic natamycin by topical administration on eye due to the hydrolysable properties of PGMA segments of micelle. Hydrolysis of glycidyl groups within a physiologically relevant environment provides an additional driving force for drug release by generation of hydrophilic hydroxyl groups to 'push' the encapsulated hydrophobic drug away from the resultant hydrophilic domains and into surrounding environment.Results: In vitro and in vivo results revealed that the self-assembled micelles and the encapsulated natamycin were not cytotoxic and the released drug have strong antifungal ability to Candida albicans. Importantly, sustained natamycin release from micelles leads to the reduced administration frequency of natamycin from 8 times per day to 3 times per day in rabbits suffering from fungal keratitis (FK).Conclusion: This study demonstrates a facile method that can greatly reduce dosing frequency of natamycin administration and thus improve long-term patient compliance.

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results