Search

Primary oral melanoma is extremely rare, and the prognosis is very poor. With the development of immunotherapy, melanoma’s treatment landscape changed dramatically. Toripalimab, a recombinant programmed death receptor 1 (PD-1) monoclonal antibody, has been approved as second-line therapy for metastatic melanoma. However, the cardiac toxicity of Toripalimab is seldom reported. This article describes the application of Toripalimab on a patient who suffered from primary oral melanoma accompanied with arrhythmic mitral valve prolapse (AMVP).Case Summary: A 55-year-old Chinese female was diagnosed with BRAF wild-type oral malignant melanoma by excisional biopsy and genetic test. The melanoma quickly progressed after complete tumor resection. Combined therapy after surgical resection was applied to control the progression of melanoma. Due to this patient’s basic cardiovascular situation, sacubitril–valsartan, spironolactone, and bisoprolol were used to maintain cardiac function. After five antitumor treatment courses, we re-evaluated the patient systemically from the symptom, physical examination, and auxiliary examination. The result showed that the patient who received Toripalimab combined with chemotherapy and radiotherapy did not present severe side effects on the cardiovascular system. The cardiac function remained well.Conclusions: This case provided evidence of Toripalimab combined with chemotherapy on melanoma patients with complex cardiovascular diseases. Toripalimab demonstrated a manageable safety profile and durable clinical response. In addition, the standard CHF treatment plays a vital role in the protection of cardiac function. In a cancer patient with complex cardiovascular diseases, standard prophylactic CHF treatment should be applied at an early stage.

Academic research is often boring and difficult to read, which makes academic research and its achievements monopolized by educated people. However, the more people can understand the academic research, the higher the value of academic research can achieve. Visualization is an effective way to make complex research easier to read by people of different levels of education. We use visualization to present the citation in graduation thesis captured in the past ten years, and take this research as an example to explore the concrete application of visual narration in academic research.

In the paper, a high linearity quadrature demodulator based on SiGe BiCMOS process is designed and implemented for 400MHz to 6GHz wireless communication application. The 3rd intermodulation cancellation technique is applied to improve linearity. A negative feedback structure is applied to Gilbert mixer to lower its input impedance and expand its bandwidth. Quadrature local oscillator signal generator is integrated, with excellent quadrature performance in the whole band. Measurement results show excellent performance in the frequency band of 400MHz to 6GHz.