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With the changing demands imposed on forests by human beings, optimizing forest management to fully utilize their multifunctionality has become a priority. Reasonable forest management measures can maintain stable forest ecosystems that fully coordinate the balance between ecological, societal, and economic aspects. As planted forests are the main application scenario of forest management worldwide, it is of great importance to understand the trade-offs between ecosystem functions and their dynamic changes in planted forests. This paper investigates the effects of different management measures on the ecosystem function of Pinus massoniana plantation forests in the subtropics. It examines four different management measures and explores how they impact multiple ecosystem function indexes and the trade-offs between ecosystem functions during forest restoration. The different management measures effectively promoted the studied ecosystem functions, with higher annual growth rates of the integrated functional indices for timber production, carbon sequestration, and biodiversity compared to the control. Over time, the ecosystem function interactions under the different management measures alternated between trade-offs and synergistic. Only the stand with a 65% harvesting intensity and replanting of various native broadleaf species was able to sustain the synergistic relationships among ecosystem functions, and the dominant function trended toward biodiversity. These observations of dynamic changes and interactions in ecosystem functions of Pinus massoniana plantation forests under various management measures will serve as a valuable reference for the sustainable management of these forests in subtropical regions. [ABSTRACT FROM AUTHOR]

Osteosarcoma (OS) is a common malignant bone tumor that occurs mostly in children and adolescents. At present, surgery after chemotherapy or postoperative adjuvant chemotherapy is the main treatment plan. However, the efficacy of chemotherapeutic drugs is limited by the occurrence of chemotherapeutic resistance, toxicity to normal cells, poor pharmacokinetic performance, and drug delivery failure. The delivery of chemotherapy drugs to the bone to treat OS may fail for a variety of reasons, such as a lack of selectivity for OS cells, initial sudden release, short‐term release, and the presence of biological barriers (such as the blood‐bone marrow barrier). Nanomaterials are new materials with at least one dimension on the nanometer scale (1–100 nm) in three‐dimensional space. These materials have the ability to penetrate biological barriers and can accumulate preferentially in tumor cells. Studies have shown that the effective combination of nanomaterials and traditional chemotherapy can significantly improve the therapeutic effect. Therefore, this article reviews the latest research progress on the use of nanomaterials in OS chemotherapy. [ABSTRACT FROM AUTHOR]

BACKGROUND: During high‐cell‐density culture of Lactobacillus fermentum, the optimal pH is often maintained by adding NaOH. During cultivation at controlled pH, L. fermentum experiences osmotic stress due to the continuous accumulation of sodium lactate as a neutralizer product, affecting its survival in subsequent processing. The purpose of this study was to evaluate the nutrient consumption patterns of L. fermentum ATCC 14931 under sodium lactate stress and to screen nutrients that help it resist osmotic stress. RESULTS: The consumption and consumption rates of amino acids, purines, pyrimidines, vitamins, and metal ions were analyzed in chemically defined media containing 0.13, 0.31, or 0.62 mm L−1 sodium lactate. The highest consumption rates were found for arginine, guanine, folic acid, and Mn2+, and the most consumed nutrients were glutamate + glutamine, guanine, ascorbic acid, and Na+. Arginine 2.58 mm L−1, guanine 0.23 mm L−1, and Mn2+ 0.25 mm L−1 were added to the medium at sodium lactate concentrations of 0.13 and 0.62 mm L−1, and arginine 2.58 mm L−1, guanine 0.26 mm L−1, and Mn2+ 0.25 mm L−1 at a sodium lactate concentration of 0.31 mm L−1. The viable cell counts of L. fermentum ATCC 14931 were approximately 1.02‐fold (P < 0.05) of the counts observed in control medium at all three concentrations of sodium lactate. CONCLUSION: The present results suggest that certain nutrients accelerate the growth of L. fermentum under sodium lactate stress and enhance its resistance to this adverse condition. © 2022 Society of Chemical Industry. [ABSTRACT FROM AUTHOR]