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Your search keyword '"Guo, Wenjie"' showing total 1,162 results
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1,162 results on '"Guo, Wenjie"'

11. Smart Design and Optimization of a Universal and Low-Cost Double-Tailed UAV

Author

Luo, Lilong, Chang, Liang, Nie, Xiaohua, Wang, Likai, Guo, Wenjie, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Tan, Kay Chen, Series Editor, and Fu, Song, editor

Published
2024
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12. Research on Multi-model Hierarchical Optimization Design Technology for Railway Body Structure

Author

Chang, Liang, Luo, Lilong, Nie, Xiaohua, Guo, Wenjie, Ceccarelli, Marco, Series Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, Agrawal, Sunil K., Advisory Editor, Carbone, Giuseppe, editor, and Laribi, Med Amine, editor

Published
2024
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34. Targeting chondrocytes for arresting bony fusion in ankylosing spondylitis.

Author

Shao, Fenli, Liu, Qianqian, Zhu, Yuyu, Fan, Zhidan, Chen, Wenjun, Liu, Shijia, Li, Xiaohui, Guo, Wenjie, Feng, Gen-Sheng, Yu, Haiguo, Xu, Qiang, and Sun, Yang

Subjects
Animals, Cell Proliferation, Chondrocytes, Chondrogenesis, Female, Inflammation, Mice, Mice, Knockout, Osteoblasts, Spondylitis, Ankylosing
Abstract

Bony fusion caused by pathological new bone formation manifests the clinical feature of ankylosing spondylitis (AS). However, the underlying mechanism remains elusive. Here we discovered spontaneous kyphosis, arthritis and bony fusion in mature CD4-Cre;Ptpn11f/f mice, which present the pathophysiological features of AS. A population of CD4-Cre-expressing proliferating chondrocytes was SHP2 deficient, which could differentiate into pre-hypertrophic and hypertrophic chondrocytes. Functionally, SHP2 deficiency in chondrocytes impeded the fusion of epiphyseal plate and promoted chondrogenesis in joint cavity and enthesis. Mechanistically, aberrant chondrocytes promoted ectopic new bone formation through BMP6/pSmad1/5 signaling. It is worth emphasizing that such pathological thickness of growth plates was evident in adolescent humans with enthesitis-related arthritis, which could progress to AS in adulthood. Targeting dysfunctional chondrogenesis with Smo inhibitor sonidegib significantly alleviated the AS-like bone disease in mice. These findings suggest that blockade of chondrogenesis by sonidegib would be a drug repurposing strategy for AS treatment.

Published
2021

40. Research Progress of Pseudogenes in Hepatocellular Carcinoma

Author

LI Kaixin, CHEN Che, ZHAO Yanyu, GUO Wenjie, and LIU Fang

Subjects
pseudogene, liver cancer, proliferate, apoptosis, invasion and metastasis, prognostic marker, therapeutic target, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Pseudogenes were initially thought to have no function and were called by aliases, such as "junk genes." With the emergence of large-scale genomics projects and more and more experimental studies, pseudogenes have been shown to play an important role in the occurrence and development of solid tumors, especially playing an important regulatory role in the occurrence and develepment of liver cancer, such as regulating the proliferation, apoptosis, invasion, metastasis, and immunity of liver cancer cells. Recent studies showed that pseudogenes can act as regulators of oncogenes and tumor suppressors in hepatocellular carcinoma (HCC) and can thus serve as prognostic markers and even therapeutic targets for this cancer type. In this review, we systematically summarize the mechanisms and functions of different pseudogenes in HCC and present their future prospects as therapeutic targets.

Published
2023
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46. Prognostic Value of Hematological Indicators in Children and Adolescents with Nasopharyngeal Carcinoma

Author

YUAN Fangqin, WANG Teng, GUO Wenjie, HE Xia, and YIN Li

Subjects
nasopharyngeal carcinoma, children, adolescents, hematological indicators, prognosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Objective To explore the prognostic value of pretreatment hematological indicators in children and adolescents with nasopharyngeal carcinoma. Methods We performed a retrospective analysis on the medical records of 79 children and adolescents (≤20 years old) with nasopharyngeal carcinoma. Before treatment, all patients underwent hematological tests, and patients received intensity-modulated radiotherapy alone or intensity-modulated radiotherapy combined with chemotherapy, targeted, and other comprehensive treatment modes. The follow-up endpoints were overall survival (OS) and progression-free survival (PFS). Results Age≤14 years, no concurrent chemotherapy, pretreatment hematological indicators (high NLR, high PLR, high LDH, and high LAR) were associated with poor OS and PFS in children and adolescents with nasopharyngeal carcinoma (all P < 0.05). No concurrent chemotherapy and high LAR before treatment were independent adverse prognostic factors for OS in children and adolescents with nasopharyngeal carcinoma. Conclusion High NLR, high PLR, high LDH, and high LAR of pretreatment hematological indicators are associated with poor OS and PFS. Meanwhile, high LAR before treatment is an independent adverse prognostic factor for OS in children and adolescents with nasopharyngeal carcinoma.

Published
2023
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47. Study on optimization method of the modular reconfigurable UAV's wing structure

Author

LUO Lilong, GUO Wenjie, and CHANG Liang

Subjects
modular, reconfigurable, unmanned aircraft vehicle, bending moment constraints, optimization design, Motor vehicles. Aeronautics. Astronautics, TL1-4050
Abstract

The design of the modular reconfigurable unmanned aircraft vehicle (UAV) has complex conditions and multiple constraints, and it is necessary to obtain the optimal scheme by means of the research on suitable optimiza-tion method according to different design thought. The study on multi-model simultaneous optimization method is carried out in this paper. The bending moment constraint method of different configurations of wing is given. The si-multaneous optimization method of multi-configuration wing under the condition of bending moment constraints for front and back beam is proposed, and the wing of a certain modular reconfigurable UAV's wing is taken as the ob-ject for application verification. The results show that, compared with the optimization results of modular wings in references, the proposed simultaneous optimization method of multi-configuration wing structure method has higher applicability and convergence, and wide engineering promotion value to solve the changing modular reconfig-urable wing structure optimization problem of the whole wing.

Published
2023
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