Search

Your search keyword '"Guo, Shanchun"' showing total 213 results
Start Over Author "Guo, Shanchun"
213 results on '"Guo, Shanchun"'

4. Novel Anti-Cancer Stem Cell Compounds: A Comprehensive Review.

Author

Guo, Shanchun, Zheng, Shilong, Liu, Mingli, and Wang, Guangdi

Abstract

Cancer stem cells (CSCs) possess a significant ability to renew themselves, which gives them a strong capacity to form tumors and expand to encompass additional body areas. In addition, they possess inherent resistance to chemotherapy and radiation therapies used to treat many forms of cancer. Scientists have focused on investigating the signaling pathways that are highly linked to the ability of CSCs to renew themselves and maintain their stem cell properties. The pathways encompassed are Notch, Wnt/β-catenin, hedgehog, STAT3, NF-κB, PI-3K/Akt/mTOR, sirtuin, ALDH, MDM2, and ROS. Recent studies indicate that directing efforts towards CSC cells is essential in eradicating the overall cancer cell population and reducing the likelihood of tumor metastasis. As our comprehension of the mechanisms that stimulate CSC activity, growth, and resistance to chemotherapy advances, the discovery of therapeutic drugs specifically targeting CSCs, such as small-molecule compounds, holds the potential to revolutionize cancer therapy. This review article examines and analyzes the novel anti-CSC compounds that have demonstrated effective and selective targeting of pathways associated with the renewal and stemness of CSCs. We also discussed their special drug metabolism and absorption mechanisms. CSCs have been the subject of much study in cancer biology. As a possible treatment for malignancies, small-molecule drugs that target CSCs are gaining more and more attention. This article provides a comprehensive review of the current state of key small-molecule compounds, summarizes their recent developments, and anticipates the future discovery of even more potent and targeted compounds, opening up new avenues for cancer treatment. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

9. Progress in Glioma Stem Cell Research.

Author

Ramar, Vanajothi, Guo, Shanchun, Hudson, BreAnna, and Liu, Mingli

Subjects
*EPIDERMAL growth factor receptors, *AUTOPHAGY, *GLIOMAS, *MICRORNA, *CELLULAR signal transduction, *STEM cell research
Abstract

Simple Summary: Glioblastoma stands as the most aggressive form of adult brain cancer, often resulting in a median survival of 14.6 months even following surgical intervention coupled with chemotherapy and radiotherapy. This review places emphasis on elucidating the current understanding of glioblastoma stem cell (GSC) biology, the intricacies of GSCs' molecular mechanisms, and their correlations with diverse signaling pathways. Notably, this includes exploration of pivotal pathways such as epidermal growth factor receptor, PI3K/AKT/mTOR, HGFR/c-MET, NF-αB, Wnt, Notch, and STAT3. Moreover, this review investigates the phenomenon of metabolic reprogramming observed within GSCs. Additionally, it delves into potential therapeutic avenues targeting GSCs, presenting current inhibitors along with their respective modes of action on GSC targets. Glioblastoma multiforme (GBM) represents a diverse spectrum of primary tumors notorious for their resistance to established therapeutic modalities. Despite aggressive interventions like surgery, radiation, and chemotherapy, these tumors, due to factors such as the blood–brain barrier, tumor heterogeneity, glioma stem cells (GSCs), drug efflux pumps, and DNA damage repair mechanisms, persist beyond complete isolation, resulting in dismal outcomes for glioma patients. Presently, the standard initial approach comprises surgical excision followed by concurrent chemotherapy, where temozolomide (TMZ) serves as the foremost option in managing GBM patients. Subsequent adjuvant chemotherapy follows this regimen. Emerging therapeutic approaches encompass immunotherapy, including checkpoint inhibitors, and targeted treatments, such as bevacizumab, aiming to exploit vulnerabilities within GBM cells. Nevertheless, there exists a pressing imperative to devise innovative strategies for both diagnosing and treating GBM. This review emphasizes the current knowledge of GSC biology, molecular mechanisms, and associations with various signals and/or pathways, such as the epidermal growth factor receptor, PI3K/AKT/mTOR, HGFR/c-MET, NF-κB, Wnt, Notch, and STAT3 pathways. Metabolic reprogramming in GSCs has also been reported with the prominent activation of the glycolytic pathway, comprising aldehyde dehydrogenase family genes. We also discuss potential therapeutic approaches to GSC targets and currently used inhibitors, as well as their mode of action on GSC targets. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

44. Fatty acid metabolism-related lncRNAs are potential biomarkers for survival prediction in clear cell renal cell carcinoma

Author

Zhang, Ming-Qing, Yang, Bai-Zhi, Wang, Zhi-Qiang, and Guo, Shanchun

Abstract

Metabolic reprogramming of energy is a newly recognized characteristic of cancer. In our current investigation, we examined the possible predictive importance of long noncoding RNAs (lncRNAs) associated to fatty acid metabolism in clear cell renal cell carcinoma (ccRCC). We conducted an analysis of the gene expression data obtained from patients diagnosed with ccRCC using the Cancer Genome Atlas (TCGA) database and the ArrayExpress database. We performed a screening to identify lncRNAs that are differentially expressed in fatty acid metabolism. Based on these findings, we developed a prognostic risk score model using these fatty acid metabolism-related lncRNAs. We then validated this model using Cox regression analysis, Kaplan–Meier survival analysis, and principal-component analysis (PCA). Furthermore, the prognostic risk score model was successfully validated using both the TCGA cohort and the E-MTAB-1980 cohort. We utilized gene set variation analysis (GSVA) and gene set enrichment analysis (GSEA) to determine the correlation between fatty acid metabolism and the PPAR signaling pathway in patients with ccRCC at various clinical stages and prognoses. We have discovered compelling evidence of the interaction between immune cells in the tumor microenvironment and tumor cells, which leads to immune evasion and resistance to drugs. This was achieved by the utilization of advanced techniques such as the CIBERSORT method, ESTIMATE R package, ssGSEA algorithm, and TIMER database exploration. Ultimately, we have established a network of competing endogenous RNA (ceRNA) that is related to fatty acid metabolism. The findings of our study suggest that medicines focused on fatty acid metabolism could be clinically significant for individuals with ccRCC. The utilization of this risk model, which is centered around the lncRNAs associated with fatty acid metabolism, could potentially provide valuable prognostic information and hold immunotherapeutic implications for patients with ccRCC.

Published
2024
Full Text
View/download PDF

48. ZB716, a steroidal selective estrogen receptor degrader (SERD), is orally efficacious in blocking tumor growth in mouse xenograft models

Author

Guo, Shanchun, primary, Zhang, Changde, additional, Bratton, Melyssa, additional, Mottamal, Madhusoodanan, additional, Liu, Jiawang, additional, Ma, Peng, additional, Zheng, Shilong, additional, Zhong, Qiu, additional, Yang, Lin, additional, Wiese, Thomas E., additional, Wu, Yong, additional, Ellis, Matthew J., additional, Matossian, Margarite, additional, Burow, Matthew E., additional, Miele, Lucio, additional, Houtman, René, additional, and Wang, Guangdi, additional

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results