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Abstract Background The association between macronutrient intake and diabetes is unclear. We used data from the China Health and Nutrition Survey to explore the association between macronutrient intake trajectories and diabetes risk in this study. Methods We included 6755 participants who did not have diabetes at baseline and participated in at least three surveys. The energy supply ratio of carbohydrate, protein, and fat was further calculated from dietary data; different macronutrient trajectories were determined using multitrajectory models; and multiple Cox regression models were used to evaluate the association between these trajectories and diabetes. Results We found three multitrajectories: decreased low carbohydrate‐increased moderate protein‐increased high fat (DLC‐IMP‐IHF), decreased high carbohydrate‐moderate protein‐increased low fat (DHC‐MP‐ILF), and balanced‐macronutrients (BM). Compared to the BM trajectory, DHC‐MP‐ILF trajectories were significantly associated with increased risk of diabetes (hazard ratio [HR]: 3.228, 95% confidence interval [CI]: 1.571–6.632), whereas no association between DLC‐IMP‐IHF trajectories and diabetes was found in our study (HR: 0.699, 95% CI: 0.351–1.392). Conclusions The downward trend of high carbohydrate and the increasing trend of low fat increased the risk of diabetes in Chinese adults.

In order to study the law of overburden movement and the distribution range of “three zones” under the condition of coal seam group mining, based on the general situation of 42106 working face of Shendong Buertai Coal Mine, the physical experiment method of similar model is used to simulate the overburden movement characteristics of 2-2 coal and 4-2 coal successively, and the characteristics of overburden caving, stress change and strata subsidence are compared and analyzed respectively. The results show that after the mining of the upper coal seam face, the failure degree of the overlying rock is low as a whole, and the stress peak value mainly exists in the leading influence area of the working face, block hinge and so on. After the lower coal mining, the fracture zone communicates with the upper coal goaf, resulting in that the fracture zone of the goaf of the composite coal seam is much larger than that of the upper coal seam, the stress is larger than that of the upper coal seam as a whole, and the roof subsidence increases significantly. The overburden has gone through three stages of separation and separation increasing, and finally closed. The “three zones” height of 42106 working face is determined by the data measurement of observation points, and the borehole monitoring is carried out in the field to verify the rationality of similar physical simulation results.

BackgroundTo analyze the prognosis and diagnostic value of relevant hematological indexes on the survival status of patients with esophageal squamous cell carcinoma after radical surgery.MethodsThis study included 206 patients with esophageal cancer who underwent surgical R0 resection. The data, including the basic information, preoperative blood routine, albumin, fibrinogen, surgery-related information, postoperative pathology, and overall survival, of the patients were compared.ResultsThe survival and death groups showed a significant difference in overall survival (OS), the degree of differentiation, depth of infiltration, pathological stage, vascular infiltration, nerve infiltration, fibrinogen, white blood cell, neutrophils, platelet, and platelet hematocrit (P

At present, in most coal mines, the coal pillar width of goaf-side roadway driving is determined by the average mining thickness. However, the thickness of the same coal seam could be varied greatly by various factors during the formation process. The large variation of mining thickness in the fully mechanized working face leads to large difference of surrounding rock deformation and complex damage mechanism of the goaf-side roadway driving. In order to solve the above problems, FLAC3D software is used to establish a roadway model so as to analyze the surrounding rock deformation and damage law under the average mining thickness, and determine the reasonable coal pillar width. When the average mining thickness is 18 m, on the side of the solid coal, the peak supporting pressure in the coal is positively correlated with the coal pillar width. Moreover, when the coal pillar width is greater than 8 m, the growth rate of the supporting pressure slows down. Therefore, the reasonable coal pillar width should be 8 m. This paper studies the influence of mining thickness on the stability of the surrounding rock of goaf-side roadway driving in the context of determined coal pillar width. The results show that when the coal pillar width is 8 m, with the increase of mining thickness, the shear damage area of roof increases, and the rock deformation range and the roof subsidence increase. However, the shear damage area of two sides and the distance between the two sides decrease. When the mining thickness is less than 18 m, the peak support pressure in the coal pillar is negatively correlated with the mining thickness. When the mining thickness is greater than 18 m, the peak support pressure in the coal pillar is positively correlated with the mining thickness, but the growth is small. According to the simulation analysis results, it is concluded that the increase of mining thickness is beneficial to the control of the surrounding rock along the two sides of the goaf roadway, but not beneficial to the roof maintenance. For areas with large mining thickness, anchor rods should be added to strengthen support in time. The actual application on site verifies the reliability and validity of the research in this paper.

Current research on mine pressure law of working face mainly focus on mine pressure law and roof structure of large mining height working face with shallow burial depth, but there's few researches on behaviors law and control technology of strong mine pressure of fully mechanized top coal caving mining face with shallow burial depth. For the above problem, taking 42202 working face of a coal mine as research background, behaviors law of strong mine pressure of working face was researched using actual measurement method combining support monitoring and micro-seismic monitoring of working face: the first weighting interval of 42202 working face is 60 m, and periodic weighting interval is 18-26 m. When pressure is weighting, dynamic load coefficient of the support is as high as 1.58, depth of rib spalling is up to 1 100 mm, and shrinkage of the support is 50-80 mm. The strong mime pressure causes working face to crush support. When pressure is applied, the pressure in the middle part is large, while pressure on both sides are small, indicating that mine pressure appears more violently when working face pressure comes; Micro-seismic events are mainly concentrated in the advance position of the working face and auxiliary transportation roadway, and the change trend of daily cumulative energy and daily frequency is basically the same. The mechanism of strong mine pressure of fully mechanized top coal caving mining face with shallow burial depth was analyzed, it is pointed out that the main reason of the strong mine pressure on working face is joint instability effect between 'voussoir beam' structure formed by upper key strata and 'cantilever beam' structure formed by lower key strata. In view of the problem of strong mine pressure, weakening measure of roof caused by hydraulic fracturing was proposed. After adopting hydraulic fracturing measure, the maximum working resistance of support decreases from 59.1 MPa to 50.1 MPa, reducing by about 15%.The maximum stress of deep hole decreased by 15%, and the maximum stress of shallow hole decreased by 32%, indicating that hydraulic fracturing had a significant effect on roof weakening and roadway surrounding rock stress weakening.

Cancer has always been the biggest threat to human health, but the effect of traditional treatments such as surgery, chemotherapy, and radiotherapy is not satisfactory. Currently, nanomedicine-based chemoimmunotherapy can improve clinical results through unique synergistic effects. However, it is mainly enriched at tumor sites based on EPR effects, without an active delivery strategy and relatively low tumor targeting distribution. Therefore, nanorobots (Cu@MPS-GOD) with magnetic responsiveness and enzyme-like activity were prepared, which can enrich and move to the tumor site under the action of a 3D magnetic field, and cause tumor cell immunogenic death by cascade catalytic Fenton reactions. Meanwhile, Cu@MPS-GOD can also activate immune cells or induce cancer cells to expose surface antigens, trigger systemic anti-cancer immunity, and have a good inhibitory effect on a breast tumor model in mice with an inhibition rate of 59.3%. This work provides an attractive strategy to expand the therapeutic effect of cancer when chemical dynamic therapy is combined with immunotherapy, which has a potential clinical application prospect. [ABSTRACT FROM AUTHOR]