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254 results on '"Guo, Ming-Lei"'

2. Ultra-Low Noise L-Band Cryogenic Astronomical Receiver for FAST Telescope

Author

Liu, Hong-Fei, He, Chuan, Wang, Jin, Jiang, Peng, Wang, Sheng-Wang, Wu, Yang, Zhang, Hang, Song, Jin-You, Shi, Xiang-Wei, and Guo, Ming-Lei

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

This paper presents an ultra-low noise L-band radio astronomical cryogenic receiver for FAST telescope. The development of key low noise microwave parts of Coupling-LNA and conical quad-ridge OMT and reasonable system integration achieve outstanding performance of receiver.It covers the frequency range of 1.2 GHz to 1.8 GHz. Novel cryogenic Coupling-LNAs with low noise, large return loss, high dynamic range and the function of coupling calibration signals are developed for the proposed receiver.Amplification and coupling function circuits are integrated as a single Coupling-LNA with full noise temperature of 4 K at the physical temperature of 15 K. And its return loss is more than 18 dB, and output 1 dB compression power is +5 dBm. A cryogenic dewar is fabricated to provide 55 K and 15 K cryogenic environment for OMT and Coupling-LNAs, respectively. The receiver's system noise temperature is below 9 K referred to feed aperture plane. Benefiting from optimal design and precise mechanical treatment, good scattering performance of OMT and equalized radiation patterns of horn are achieved with an antenna efficiency above 75%., Comment: There are 20 pages and 24 figures

Published
2021
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3. Reversing neural circuit and behavior deficit in mice exposed to maternal inflammation by Zika virus

Author

Ma, Li, Wang, Jing, Ge, Jianlong, Wang, Yuan, Zhang, Wei, Du, Yuanning, Luo, Jun, Li, Yangping, Wang, Feng, Fan, Guoping, Chen, Rong, Yao, Bing, Zhao, Zhen, Guo, Ming‐Lei, Kim, Woong‐Ki, Chai, Yang, and Chen, Jian‐Fu

Subjects
Behavioral and Social Science, Mental Health, Pediatric, Neurosciences, Basic Behavioral and Social Science, Brain Disorders, Aetiology, 2.1 Biological and endogenous factors, Mental health, Neurological, Reproductive health and childbirth, Good Health and Well Being, Animals, Female, Hippocampus, Inflammation, Mice, Prefrontal Cortex, Pregnancy, Zika Virus, Zika Virus Infection, chemogenetics, mouse behaviors, neural circuit, Zika virus, Biochemistry and Cell Biology, Developmental Biology
Abstract

Zika virus (ZIKV) infection during pregnancy is linked to various developmental brain disorders. Infants who are asymptomatic at birth might have postnatal neurocognitive complications. However, animal models recapitulating these neurocognitive phenotypes are lacking, and the circuit mechanism underlying behavioral abnormalities is unknown. Here, we show that ZIKV infection during mouse pregnancy induces maternal immune activation (MIA) and leads to autistic-like behaviors including repetitive self-grooming and impaired social memory in offspring. In the medial prefrontal cortex (mPFC), ZIKV-affected offspring mice exhibit excitation and inhibition imbalance and increased cortical activity. This could be explained by dysregulation of inhibitory neurons and synapses, and elevated neural activity input from mPFC-projecting ventral hippocampus (vHIP) neurons. We find structure alterations in the synaptic connections and pattern of vHIP innervation of mPFC neurons, leading to hyperconnectivity of the vHIP-mPFC pathway. Decreasing the activity of mPFC-projecting vHIP neurons with a chemogenetic strategy rescues social memory deficits in ZIKV offspring mice. Our studies reveal a hyperconnectivity of vHIP to mPFC projection driving social memory deficits in mice exposed to maternal inflammation by ZIKV.

Published
2021

17. An Ultra-wide Bandwidth Low-frequency Radio Astronomical Cryogenic Receiver for FAST Telescope

Author

Liu, Hong-Fei, primary, Jiang, Peng, additional, He, Chuan, additional, Yang, Fan, additional, Liu, Hong-Ju, additional, Wang, Sheng-Wang, additional, Wu, Yang, additional, Zhu, Yan, additional, Cao, Yang, additional, Song, Jin-You, additional, Shi, Xiang-Wei, additional, Guo, Ming-Lei, additional, Zhang, Hang, additional, and Liu, Wen-Hao, additional

Published
2022
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22. Microglia NLRP3 Inflammasome and Neuroimmune Signaling in Substance Use Disorders.

Author

Guo, Ming-Lei, Roodsari, Soheil Kazemi, Cheng, Yan, Dempsey, Rachael Elizabeth, and Hu, Wenhui

Subjects
*NLRP3 protein, *SUBSTANCE abuse, *MARIJUANA, *INFLAMMASOMES, *MICROGLIA, *COCAINE, *REACTIVE oxygen species
Abstract

During the last decade, substance use disorders (SUDs) have been increasingly recognized as neuroinflammation-related brain diseases. Various types of abused drugs (cocaine, methamphetamine, alcohol, opiate-like drugs, marijuana, etc.) can modulate the activation status of microglia and neuroinflammation levels which are involved in the pathogenesis of SUDs. Several neuroimmune signaling pathways, including TLR/NF-кB, reactive oxygen species, mitochondria dysfunction, as well as autophagy defection, etc., have been implicated in promoting SUDs. Recently, inflammasome-mediated signaling has been identified as playing critical roles in the microglia activation induced by abused drugs. Among the family of inflammasomes, NOD-, LRR-, and pyrin-domain-containing protein 3 (NLRP3) serves the primary research target due to its abundant expression in microglia. NLRP3 has the capability of integrating multiple external and internal inputs and coordinately determining the intensity of microglia activation under various pathological conditions. Here, we summarize the effects of abused drugs on NLRP3 inflammasomes, as well as others, if any. The research on this topic is still at an infant stage; however, the readily available findings suggest that NLRP3 inflammasome could be a common downstream effector stimulated by various types of abused drugs and play critical roles in determining abused-drug-mediated biological effects through enhancing glia–neuron communications. NLRP3 inflammasome might serve as a novel target for ameliorating the development of SUDs. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Sleep-Disturbance-Induced Microglial Activation Involves CRH-Mediated Galectin 3 and Autophagy Dysregulation.

Author

Guo, Liyang, Reed, Kirstin M., Carter, Ashley, Cheng, Yan, Roodsari, Soheil Kazemi, Martinez Pineda, Damian, Wellman, Laurie L., Sanford, Larry D., and Guo, Ming-Lei

Subjects
LYSOSOMES, SLEEP interruptions, AUTOPHAGY, SLEEP quality, CORTICOTROPIN releasing hormone, MICROGLIA
Abstract

Chronic sleep disturbances (CSDs) including insomnia, insufficient sleep time, and poor sleep quality are major public health concerns around the world, especially in developed countries. CSDs are major health risk factors linked to multiple neurodegenerative and neuropsychological diseases. It has been suggested that CSDs could activate microglia (Mg) leading to increased neuroinflammation levels, which ultimately lead to neuronal dysfunction. However, the detailed mechanisms underlying CSD-mediated microglial activation remain mostly unexplored. In this study, we used mice with three-weeks of sleep fragmentation (SF) to explore the underlying pathways responsible for Mg activation. Our results revealed that SF activates Mg in the hippocampus (HP) but not in the striatum and prefrontal cortex (PFc). SF increased the levels of corticotropin-releasing hormone (CRH) in the HP. In vitro mechanism studies revealed that CRH activation of Mg involves galectin 3 (Gal3) upregulation and autophagy dysregulation. CRH could disrupt lysosome membrane integrity resulting in lysosomal cathepsins leakage. CRHR2 blockage mitigated CRH-mediated effects on microglia in vitro. SF mice also show increased Gal3 levels and autophagy dysregulation in the HP compared to controls. Taken together, our results show that SF-mediated hippocampal Mg activation involves CRH mediated galectin 3 and autophagy dysregulation. These findings suggest that targeting the hippocampal CRH system might be a novel therapeutic approach to ameliorate CSD-mediated neuroinflammation and neurodegenerative diseases. [ABSTRACT FROM AUTHOR]

Published
2023
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32. Interfacial “Anchoring Effect” Enables Efficient Large‐Area Sky‐Blue Perovskite Light‐Emitting Diodes

Author

Shen, Yang, primary, Wang, Jing‐Kun, additional, Li, Yan‐Qing, additional, Shen, Kong‐Chao, additional, Su, Zhen‐Huang, additional, Chen, Li, additional, Guo, Ming‐Lei, additional, Cai, Xiao‐Yi, additional, Xie, Feng‐Ming, additional, Qian, Xiao‐Yan, additional, Gao, Xingyu, additional, Zhidkov, Ivan S., additional, and Tang, Jian‐Xin, additional

Published
2021
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36. Unraveling the Role of Crystallization Dynamics on Luminescence Characteristics of Perovskite Light‐Emitting Diodes

Author

Shen, Kong‐Chao, primary, Wang, Jing‐Kun, additional, Shen, Yang, additional, Li, Yan‐Qing, additional, Guo, Ming‐Lei, additional, Su, Zhen‐Huang, additional, Lu, Lin‐Yang, additional, Cai, Xiao‐Yi, additional, Chen, Li, additional, Song, Fei, additional, Gao, Xing‐Yu, additional, Tang, Jian‐Xin, additional, and Ueno, Nobuo, additional

Published
2021
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46. The time and frequency standard system for FAST receivers

Author

Zhu, Kai, primary, Fan, Jin, additional, Liang, Kun, additional, Tang, Wei, additional, Gao, Zhi-Sheng, additional, Zhu, Yan, additional, Feng, Yi, additional, Zhu, Wei-Wei, additional, Qian, Lei, additional, Yue, You-Ling, additional, Song, Jin-You, additional, Shi, Xiang-Wei, additional, Wang, Xing-Yi, additional, Guo, Ming-Lei, additional, Zhang, Hang, additional, Gan, Heng-Qian, additional, Liu, Hong-Fei, additional, Jin, Cheng-Jin, additional, and Jiang, Peng, additional

Published
2020
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