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220 results on '"Guo, Lingyun"'

19. Precise Design of TiO2@CoOx Heterostructure via Atomic Layer Deposition for Synergistic Sono‐Chemodynamic Oncotherapy

Author

Liu, Wen, primary, Shao, Runrun, additional, Guo, Lingyun, additional, Man, Jianliang, additional, Zhang, Chengwu, additional, Li, Lihong, additional, Wang, Haojiang, additional, Wang, Bin, additional, Guo, Lixia, additional, Ma, Sufang, additional, Zhang, Bin, additional, Diao, Haipeng, additional, Qin, Yong, additional, and Yan, Lili, additional

Published
2024
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27. Precise Design of TiO2@CoOx Heterostructure via Atomic Layer Deposition for Synergistic Sono‐Chemodynamic Oncotherapy.

Author

Liu, Wen, Shao, Runrun, Guo, Lingyun, Man, Jianliang, Zhang, Chengwu, Li, Lihong, Wang, Haojiang, Wang, Bin, Guo, Lixia, Ma, Sufang, Zhang, Bin, Diao, Haipeng, Qin, Yong, and Yan, Lili

Subjects
ATOMIC layer deposition, REACTIVE oxygen species, ENERGY bands, TUMOR microenvironment, TUMOR treatment
Abstract

Sonodynamic therapy (SDT), a tumor treatment modality with high tissue penetration and low side effects, is able to selectively kill tumor cells by producing cytotoxic reactive oxygen species (ROS) with ultrasound‐triggered sonosensitizers. N‐type inorganic semiconductor TiO2 has low ROS quantum yields under ultrasound irradiation and inadequate anti‐tumor activity. Herein, by using atomic layer deposition (ALD) to create a heterojunction between porous TiO2 and CoOx, the sonodynamic therapy efficiency of TiO2 can be improved. Compared to conventional techniques, the high controllability of ALD allows for the delicate loading of CoOx nanoparticles into TiO2 pores, resulting in the precise tuning of the interfaces and energy band structures and ultimately optimal SDT properties. In addition, CoOx exhibits a cascade of H2O2→O2→·O2− in response to the tumor microenvironment, which not only mitigates hypoxia during the SDT process, but also contributes to the effect of chemodynamic therapy (CDT). Correspondingly, the synergistic CDT/SDT treatment is successful in inhibiting tumor growth. Thus, ALD provides new avenues for catalytic tumor therapy and other pharmaceutical applications. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Multimodal imaging and photothermal/chemodynamic therapy of cervical cancer using GSH-responsive nanoparticles

Author

Shao, runrun, primary, qiao, xiaofang, additional, Cao, Linlin, additional, man, jianliang, additional, guo, lingyun, additional, li, lanlan, additional, liu, wen, additional, li, lihong, additional, wang, bin, additional, guo, lixia, additional, ma, sufang, additional, zhang, boye, additional, wang, haojiang, additional, and Yan, Lili, additional

Published
2023
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45. Additional file 1 of Clinical characteristics of central nervous system candidiasis due to Candida albicans in children: a single-center experience

Author

Xiao, Haijuan, Miao, Yiqing, Liu, Linlin, Feng, Wenya, Liu, Shuping, Guo, Lingyun, Guo, Xin, Chen, Tianming, Hu, Bing, Hu, Huili, Xu, Fang, Han, Lianlian, Ren, Lili, Li, Wei, and Liu, Gang

Abstract

Additional file 1: Table S1. Types of infection of 33 CNSC patients. Table S2. Sites of infection of 33 CNSC patients. Table S3. Drug susceptibility test results of 27 strains of Candida albicans. Table S4. Antifungal drugs used in CNSC patients. Table S5. Other medical treatment regimens used in CNSC patients. Figure S1. Number of patients with CNSC and patients with different sites of infection from March 2010 to March 2019. Figure S2. The WES result of 1 CNSC patient indicated CARD9 compound heterozygous mutations.

Published
2023
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46. Multimodal imaging and photothermal/chemodynamic therapy of cervical cancer using GSH-responsive MoS2@MnO2 theranostic nanoparticles.

Author

Shao, Runrun, Qiao, Xiaofang, Cao, Linlin, Man, Jianliang, Guo, Lingyun, Li, Lanlan, Liu, Wen, Li, Lihong, Wang, Bin, Guo, Lixia, Ma, Sufang, Zhang, Boye, Wang, Haojiang, and Yan, Lili

Subjects
CERVICAL cancer, MOLYBDENUM disulfide, MAGNETIC resonance imaging, PHOTOTHERMAL effect, NANOPARTICLES, CANCER treatment, MOLYBDENUM sulfides
Abstract

The development of nanoparticles capable of inducing reactive oxygen species (ROS) formation has become an important strategy for cancer therapy. Simultaneously, the preparation of multifunctional nanoparticles that respond to the tumor microenvironment is crucial for the diagnosis and treatment of tumors. In this study, we designed a Molybdenum disulfide (MoS2) core coated with Manganese dioxide (MnO2), which possessed a good photothermal effect and could produce Fenton-like Mn2+ in response to highly expressed glutathione (GSH) in the tumor microenvironment, thereby generating a chemodynamic therapy (CDT). The nanoparticles were further modified with Methoxypoly(Ethylene Glycol) 2000 (mPEG-NH2) to improve their biocompatibility, resulting in the formation of MoS2@MnO2-PEG. These nanoparticles were shown to possess significant Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) imaging capabilities, making them useful in tumor diagnosis. In vitro and in vivo experiments demonstrated the antitumor ability of MoS2@MnO2-PEG, with a significant killing effect on tumor cells under combined treatment. These nanoparticles hold great potential for CDT/photothermal therapy (PTT) combined antitumor therapy and could be further explored in biomedical research. [ABSTRACT FROM AUTHOR]

Published
2023
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