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445 results on '"Gunnarsson C"'

1. Methods for evaluating HER2 status in breast cancer: comparison of IHC, FISH, and real-time PCR analysis of formalin-fixed paraffin-embedded tissue

Author

Olsson H, Jansson A, Holmlund B, and Gunnarsson C

Subjects
Pathology, RB1-214
Abstract

Hans Olsson,1,2 Agneta Jansson,3 Birgitta Holmlund,3 Cecilia Gunnarsson2,4 1Molecular and Immunological Pathology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden; 2Department of Clinical Pathology and Clinical Genetics, Östergötland County Council, Linköping, Sweden; 3Division of Oncology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden; 4Division of Genetics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden Abstract: The human epidermal growth factor receptor 2 gene (HER2) is amplified in approximately 15%–20% of all breast cancers. This results in overexpression of the HER2 protein, which is associated with worse clinical outcomes in breast cancer patients. Several studies have shown that trastuzumab, a monoclonal antibody that interferes with the HER2/neu receptor, can improve overall survival in patients with HER2-positive breast cancer. Immunohistochemistry (IHC), combined with different methods for in situ hybridization, is currently used for routine assessment of HER2 status. The aim of the present study was to determine whether real-time polymerase chain reaction (PCR) can serve as a supplementary method for evaluation of HER2 status in primary breast cancer. For this purpose, 145 formalin-fixed paraffin-embedded primary breast cancer samples were tested by real-time PCR amplification of HER2, using amyloid precursor protein as a reference. The results were compared with HER2 status determined by fluorescence in situ hybridization (FISH) and IHC. The specificity, sensitivity, and reproducibility of real-time PCR were evaluated, and a comparison of formalin-fixed and fresh-frozen samples was performed. This showed concordance of 93% between real-time PCR and FISH, and 86% between real-time PCR and IHC. Therefore, we suggest that real-time PCR can be a useful supplementary method for assessment of HER2 status. Keywords: 17q, breast cancer, HER2, real-time PCR

Published
2013

3. High-Rate Fracture of Human Skull

Author

Gunnarsson, C. Allan, Alexander, Stephen, Rafaels, Karin, Walter, Tim, Weerasooriya, Tusit, Zimmerman, Kristin B., Series Editor, Grady, Martha, editor, Minary, Majid, editor, Starman, La Vern, editor, Hay, Jenny, editor, and Notbohm, Jacob, editor

Published
2019
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35. enSustainable Straw Potential in Sweden - a Case Study to Supply Straw for Ethanol Production

Author

Gunnarsson, C., Lund, J., Casimir, J., and Myrbeck, Å.

Subjects
Biomass
Abstract

When agriculture is to supply a growing bioeconomy with biomass, straw has been identified as one of residues with the largest potential. As removal of straw from fields will have a negative impact on soil humus development compared with straw incorporation it is important to make sure that a system including straw removal does not negatively effect the long-term soil fertility. As part of the EU-financed project AGROinLOG a Swedish demonstration case was made to supply 80,000 tonnes of winter wheat straw annually to 2nd generation bioethanol production. The straw removal from the case study area of Norrköping and surrounding counties, in the south-eastern part of Sweden, was evaluated from a soil fertility aspect using a model that estimates the sustainability of a cropping system regarding soil fertility and yield levels based on humus content, climate and soil type. The assessment revealed the possibility to remove 230,000 tonnes of winter wheat straw from the surrounding counties of Norrköping without reaching the humus limit. The margin to 80,000 tonnes is large and collecting this amount of winter wheat straw annually may well be possible.

Published
2020
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36. enFrom Agroindustries to Integrated Biomass Logistics Centres. AGROinLOG Project: Summary of Final Results

Author

Gómez, M., Zapata, S., Izquierdo, M., Jarauta-Córdoba, C., Annevelink, B., Snels, J., Urciuoli, L., Kougioumtzis, M.A., Karampinis, M., Grammelis, P., Gunnarsson, C., Lund, J., Pari, L., Suardi, A., Serrat, C., Boukis, I., Karlsson Boll, D., Gustafsson, T., Fernández, P., Rivera, S., Stavropoulou, C., Sanchez Falcon, B., Kravchenko, A., Stojiljkovic, D., and Bartolomé, C.

Subjects
Biomass
Abstract

AGROinLOG project has tested the integrated biomass logistics centres (IBLC) concept in three real agro-industries in Europe. The relevance of the IBLC strategy relies on the fact that it allows agro-industries to create a new activity with lower investment, increasing incomes, stabilizing their annual activity (avoiding idle periods) and maintaining or creating new jobs. The demos’ studies were performed in Spain at a fodder industry, in Greece at an olive oil industry, and in Sweden inside a cereal processing industry. AGROinLOG validated these demos´ business models from a holistic perspective, also studying the replicability of the IBLC business model in other agro-industries from different sectors (vegetable oil extraction, olive oil chain, feed & fodder, wine, grain chain and sugar industry). Sectorial analysis was carried out as well, allowing the identification of opportunities among the targeted sector to replicate the IBLC concept, drawing barriers to overcome in each case. Thus, technical, economic and environmental feasibility of integrated biomass logistics centers (IBLCs) for food and non-food products have been assessed in detail.

Published
2020
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38. From agroindustries to integrated biomass logistics centres. Agroinlog project: Summary of final results

Author

Gómez, M., Zapata, S., Izquierdo, M., Jarauta-Córdoba, C., Annevelink, E., Snels, J., Urciuoli, L., Kougioumtzis, M.A., Karampinis, E., Grammelis, P., Gunnarsson, C., Lund, J., Pari, L., Suardi, A., Serrat, C., Boukis, I., Karlsson Boll, D., Gustafsson, T., Fernández, P., Rivera, S., Stavropoulou, C., Sanchez Falcon, B., Kravchenko, A., Stojiljković, Dragoslava, Bartolomé, C., Gómez, M., Zapata, S., Izquierdo, M., Jarauta-Córdoba, C., Annevelink, E., Snels, J., Urciuoli, L., Kougioumtzis, M.A., Karampinis, E., Grammelis, P., Gunnarsson, C., Lund, J., Pari, L., Suardi, A., Serrat, C., Boukis, I., Karlsson Boll, D., Gustafsson, T., Fernández, P., Rivera, S., Stavropoulou, C., Sanchez Falcon, B., Kravchenko, A., Stojiljković, Dragoslava, and Bartolomé, C.

Abstract

AGROinLOG project has tested the integrated biomass logistics centres (IBLC) concept in three real agro-industries in Europe. The relevance of the IBLC strategy relies on the fact that it allows agro-industries to create a new activity with lower investment, increasing incomes, stabilizing their annual activity (avoiding idle periods) and maintaining or creating new jobs. The demos’ studies were performed in Spain at a fodder industry, in Greece at an olive oil industry, and in Sweden inside a cereal processing industry. AGROinLOG validated these demos´ business models from a holistic perspective, also studying the replicability of the IBLC business model in other agro-industries from different sectors (vegetable oil extraction, olive oil chain, feed & fodder, wine, grain chain and sugar industry). Sectorial analysis was carried out as well, allowing the identification of opportunities among the targeted sector to replicate the IBLC concept, drawing barriers to overcome in each case. Thus, technical, economic and environmental feasibility of integrated biomass logistics centers (IBLCs) for food and non-food products have been assessed in detail.

Published
2020

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