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1. DETERMINATION OF FETAL RHESUS D STATUS BY MATERNAL PLASMA DNA ANALYSIS

Author

Aykut A., Onay H., Gunduz C., Ozkinay F., Cogulu O., and Sagol S.

Subjects
rhesus d (rhd), non invasive prenatal diagnosis, Genetics, QH426-470
Abstract

In this study, we assessed the feasibility of fetal RhD genotyping by analysis of cell-free fetal DNA(cffDNA) extracted from plasma samples of Rhesus (Rh) D-negative pregnant women by using real-time polymerase chain reaction (PCR). Fetal genotyping was performed on 30 RhD-negative women between 9 and 39 weeks of gestation who were referred to us for invasive testing [amniocentesis/ chorionic villi sampling (CVS)]. The fetal RHD genotype was determined based on real-time PCR method. Exons 7 and 10 of the RHD and SRY genes were targeted. Among the pregnant women, 12 were carrying male and 17 were carrying female fetuses. Out of 29 pregnant women, 21 had RhD-positive and nine had RhD-negative fetuses. One sample )case 12, whose blood group was found to be AB Rh [+] (was excluded due to controversial results from repeated serological analyses. All prenatal results were in concordance with postnatal RhD status and fetal sex without false- positive or -negative results. Performing real-time PCR on cffDNA showed accurate, efficient and reliable results, allowing rapid and high throughput non invasive determination of fetal sex and RhD status in clinical samples.

Published
2013
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2. Clinical and molecular evaluation of MEFV gene variants in the Turkish population: a study by the National Genetics Consortium

Author

Dundar, Munis, Fahrioglu, Umut, Yildiz, Saliha Handan, Bakir-Gungor, Burcu, Temel, Sehime Gulsun, Akin, Haluk, Artan, Sevilhan, Cora, Tulin, Sahin, Feride Iffet, Dursun, Ahmet, Sezer, Ozlem, Gurkan, Hakan, Erdogan, Murat, Gunduz, C. Nur Semerci, Bisgin, Atil, Ozdemir, Ozturk, Ulgenalp, Ayfer, Percin, E. Ferda, Yildirim, Malik Ejder, Tekes, Selahaddin, Bagis, Haydar, Yuce, Huseyin, Duman, Nilgun, Bozkurt, Gokay, Yararbas, Kanay, Yildirim, Mahmut Selman, Arman, Ahmet, Mihci, Ercan, Eraslan, Serpil, Altintas, Zuhal Mert, Aymelek, Huri Sema, Ruhi, Hatice Ilgin, Tatar, Abdulgani, Ergoren, Mahmut Cerkez, Cetin, G. Ozan, Altunoglu, Umut, Caglayan, Ahmet Okay, Yuksel, Berrin, Ozkul, Yusuf, Saatci, Cetin, Kenanoglu, Sercan, Karasu, Nilgun, Dundar, Bilge, Ozcelik, Firat, Demir, Mikail, Siniksaran, Betul Seyhan, Kulak, Hande, Kiranatlioglu, Kubra, Baysal, Kubra, Kazimli, Ulviyya, Akalin, Hilal, Dundar, Ayca, Boz, Mehmet, Bayram, Arslan, Subasioglu, Asli, Colak, Fatma Kurt, Karaduman, Neslihan, Gunes, Meltem Cerrah, Kandemir, Nefise, Aynekin, Busra, Emekli, Rabia, Sahin, Izem Olcay, Ozdemir, Sevda Yesim, Onal, Muge Gulcihan, Senel, Abdurrahman Soner, Poyrazoglu, Muammer Hakan, Kisaarslan, Ayse Nur Pac, Gursoy, Sebnem, Baskol, Mevlut, Calis, Mustafa, Demir, Huseyin, Zararsiz, Gozde Erturk, Erdogan, Mujgan Ozdemir, Elmas, Muhsin, Solak, Mustafa, Ulu, Memnune Sena, Thahir, Adam, Aydin, Zafer, Atasever, Umut, Sag, Sebnem Ozemri, Aliyeva, Lamiya, Alemdar, Adem, Dogan, Berkcan, Erguzeloglu, Cemre Ornek, Kaya, Niyazi, Ozkinay, Ferda, Cogulu, Ozgur, Durmaz, Asude, Onay, Huseyin, Karaca, Emin, Durmaz, Burak, Aykut, Ayca, Cilingir, Oguz, Aras, Beyhan Durak, Gokalp, Ebru Erzurumluoglu, Arslan, Serap, Temena, Arda, Haziyeva, Konul, Kocagil, Sinem, Bas, Hasan, Susam, Ezgi, Keklikci, Ali Riza, Sarac, Elif, Kocak, Nadir, Nergiz, Suleyman, Terzi, Yunus Kasim, Dincer, Selin Akad, Baskin, Esra Sidika, Genc, Gunes Cakmak, Bahadir, Oguzhan, Sanri, Aslihan, Yigit, Serbulent, Tozkir, Hilmi, Yalcintepe, Sinem, Ozkayin, Nese, Kiraz, Aslihan, Balta, Burhan, Gonen, Gizem Akinci, Kurt, E. Emre, Ceylan, Gulay Gulec, Ceylan, Ahmet Cevdet, Erten, Sukran, Bozdogan, Sevcan Tug, Boga, Ibrahim, Yilmaz, Mustafa, Silan, Fatma, Kocabey, Mehmet, Koc, Altug, Cankaya, Tufan, Bora, Elcin, Bozkaya, Ozlem Giray, Ercal, Derya, Ergun, Mehmet Ali, Ergun, Sezen Guntekin, Duman, Yesim Sidar, Beyazit, Serife Busra, Uzel, Veysiye Hulya, Em, Serda, Cevik, Muhammer Ozgur, Eroz, Recep, Demirtas, Mercan, Firat, Cem Koray, Kabayegit, Zehra Manav, Altan, Mustafa, Mardan, Lamiya, Sayar, Ceyhan, Tumer, Sait, Turkgenc, Burcu, Karakoyun, Hilal Keskin, Tunc, Betul, Kuru, Seda, Zamani, Aysegul, Geckinli, Bilgen Bilge, Ates, Esra Arslan, Clark, Ozden Altiok, Toylu, Asli, Coskun, Mert, Nur, Banu, Bilge, Ilmay, Bayramicli, Oya Uygur, Emmungil, Hakan, Komesli, Zeynep, Zeybel, Mujdat, Gurakan, Figen, Tasdemir, Mehmet, Kebudi, Rejin, Karabulut, Halil Gurhan, Tuncali, Timur, Kutlay, Nuket Yurur, Kahraman, Cigdem Yuce, Onder, Nerin Bahceciler, Beyitler, Ilke, Kavukcu, Salih, Tulay, Pinar, Tosun, Ozgur, Tuncel, Gulten, Mocan, Gamze, Kale, Hamdi, Uyguner, Zehra Oya, Acar, Aynur, Altinay, Mert, and Erdem, Levent

Published
2022
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4. A new scoring system to predict mortality in community-acquired pneumonia: CURB (S)-65.

Author

BAHÇECIOĞLU, S. N., KÖKTÜRK, N., BAHA, A., YAPAR, D., AKSAKAL, F. N. B., GUNDUZ, C., TASBAKAN, S., SAYINER, A., COSKUN, A. S., YAMAN, F., ÇILLI, A., CELENK, B., KILINÇ, O., MERSIN, S. S., HAZAR, A., and TOKGOZ, F.

Abstract

OBJECTIVE: The first decision to be made in the case of community-acquired pneumonia (CAP) is whether hospitalization of the patient is mandatory. In this study, we aimed to investigate whether the addition of oxygenation parameters to CURB-65 has diagnostic value in predicting mortality in CAP. PATIENTS AND METHODS: A total of 903 CAP patients were included in the study. Patients with a CURB-65 score of 0 and 1 were classified as Group 1 and patients with a CURB-65 score of 2 or more were classified as Group 2. The prediction of mortality through Pneumonia Severity Index (PSI), CURB-65 and CURBS-65/ CURBP-65 with the addition of SaO2 and PaO2 values; hence the four different models, was compared among all patient groups. RESULTS: As a result, 3.3% of the cases in Group 1 and 12.7% of the cases in Group 2 died. In both CURB-65 groups, it was noted that the frequency of patients with SaO2 <90% was significantly higher in the dead group than in the alive patient group (p=0.009 and p=0.001, respectively). In the univariate analysis, PaO2<60, and SaO2<90 were significantly associated with mortality. Model 2 (CURBS-65) and Model 3 (CURBP- 65) were examined, SaO2<90 (OR 2.08) was found to have an effect on death. In predicting mortality by the receiver operating characteristics (ROC) analysis, it was understood that the CURBS-65 score had a slightly higher area under the curve (AUC) value than CURB-65. CONCLUSIONS: As a result, it has been shown that the use of CURBS-65 scoring instead of CURB-65 clinical scoring may be more useful in predicting mortality. [ABSTRACT FROM AUTHOR]

Published
2023

6. Sleep apnoea management in Europe during the COVID-19 pandemic – Data from the European Sleep Apnoea Database (ESADA)

Author

Grote, L, Mcnicholas, W, Hedner, J, Anttalainen, U, Saaresranta, T, Basoglu, O, Gunduz, C, Tasbakan, S, Bouloukaki, I, Schiza, S, Bonsignore, M, Marrone, O, Petitjean, M, Roisman, G, Fietze, I, Laharnar, N, Penzel, T, Zou, D, Kent, B, Ryan, S, Kvamme, J, Bailly, S, Pepin, J, Tamisier, R, Lombardi, C, Parati, G, Pataka, A, Plywaczewski, R, Sliwinski, P, Pretl, M, Riha, R, Staats, R, Steiropoulos, P, Joppa, P, Verbraecken, J, Petiet, E, Trakada, G, Ludka, O, Buskova, J, Hein, H, Drummond, M, van Zeller, M, Dogas, Z, Galic, T, Gouveris, H, Mihaicuta, S, Randerath, W, Herkenrath, S, Fanfulla, F, Testelmans, D, Grote L., McNicholas W. T., Hedner J., Anttalainen U., Saaresranta T., Basoglu O. K., Gunduz C., Tasbakan S., Bouloukaki I., Schiza S. E., Bonsignore M. R., Marrone O., Petitjean M., Roisman G., Fietze I., Laharnar N., Penzel T., Zou D., Kent B. D., Ryan S., Kvamme J. A., Bailly S., Pepin J. -L., Tamisier R., Lombardi C., Parati G., Pataka A., Plywaczewski R., Sliwinski P., Pretl M., Riha R., Staats R., Steiropoulos P., Joppa P., Verbraecken J., Petiet E., Trakada G., Ludka O., Buskova J., Hein H., Drummond M., van Zeller M., Dogas Z., Galic T., Gouveris H., Mihaicuta S., Randerath W., Herkenrath S., Fanfulla F., Testelmans D., Grote, L, Mcnicholas, W, Hedner, J, Anttalainen, U, Saaresranta, T, Basoglu, O, Gunduz, C, Tasbakan, S, Bouloukaki, I, Schiza, S, Bonsignore, M, Marrone, O, Petitjean, M, Roisman, G, Fietze, I, Laharnar, N, Penzel, T, Zou, D, Kent, B, Ryan, S, Kvamme, J, Bailly, S, Pepin, J, Tamisier, R, Lombardi, C, Parati, G, Pataka, A, Plywaczewski, R, Sliwinski, P, Pretl, M, Riha, R, Staats, R, Steiropoulos, P, Joppa, P, Verbraecken, J, Petiet, E, Trakada, G, Ludka, O, Buskova, J, Hein, H, Drummond, M, van Zeller, M, Dogas, Z, Galic, T, Gouveris, H, Mihaicuta, S, Randerath, W, Herkenrath, S, Fanfulla, F, Testelmans, D, Grote L., McNicholas W. T., Hedner J., Anttalainen U., Saaresranta T., Basoglu O. K., Gunduz C., Tasbakan S., Bouloukaki I., Schiza S. E., Bonsignore M. R., Marrone O., Petitjean M., Roisman G., Fietze I., Laharnar N., Penzel T., Zou D., Kent B. D., Ryan S., Kvamme J. A., Bailly S., Pepin J. -L., Tamisier R., Lombardi C., Parati G., Pataka A., Plywaczewski R., Sliwinski P., Pretl M., Riha R., Staats R., Steiropoulos P., Joppa P., Verbraecken J., Petiet E., Trakada G., Ludka O., Buskova J., Hein H., Drummond M., van Zeller M., Dogas Z., Galic T., Gouveris H., Mihaicuta S., Randerath W., Herkenrath S., Fanfulla F., and Testelmans D.

Published
2020

7. Long-term positive airway pressure therapy is associated with reduced total cholesterol levels in patients with obstructive sleep apnea: data from the European Sleep Apnea Database (ESADA)

Author

Gunduz, C, Basoglu, O, Kvamme, J, Verbraecken, J, Anttalainen, U, Marrone, O, Steiropoulos, P, Roisman, G, Joppa, P, Hein, H, Trakada, G, Hedner, J, Grote, L, Petiet, E, Montserrat, J, Fietze, I, Penzel, T, Ludka, O, Rodenstein, D, Masa, J, Bouloukaki, I, Schiza, S, Kent, B, Mcnicholas, W, Ryan, S, Riha, R, Schulz, R, Zou, D, Pepin, J, Levy, P, Bailly, S, Lavie, L, Lavie, P, Tasbakan, M, Varoneckas, G, Tkacova, R, Staats, R, Barbe, F, Lombardi, C, Parati, G, Drummond, M, van Zeller, M, Bonsignore, M, Petitjean, M, Pretl, M, Vitols, A, Dogas, Z, Galic, T, Pataka, A, Saaresranta, T, Plywaczewski, R, Sliwinski, P, Bielicki, P, Gunduz C., Basoglu O. K., Kvamme J. A., Verbraecken J., Anttalainen U., Marrone O., Steiropoulos P., Roisman G., Joppa P., Hein H., Trakada G., Hedner J., Grote L., Petiet E., Montserrat J. M., Fietze I., Penzel T., Ludka O., Rodenstein D., Masa J. F., Bouloukaki I., Schiza S., Kent B., McNicholas W. T., Ryan S., Riha R. L., Schulz R., Zou D., Pepin J. L., Levy P., Bailly S., Lavie L., Lavie P., Tasbakan M. S., Varoneckas G., Tkacova R., Staats R., Barbe F., Lombardi C., Parati G., Drummond M., van Zeller M., Bonsignore M. R., Petitjean M., Pretl M., Vitols A., Dogas Z., Galic T., Pataka A., Saaresranta T., Plywaczewski R., Sliwinski P., Bielicki P., Gunduz, C, Basoglu, O, Kvamme, J, Verbraecken, J, Anttalainen, U, Marrone, O, Steiropoulos, P, Roisman, G, Joppa, P, Hein, H, Trakada, G, Hedner, J, Grote, L, Petiet, E, Montserrat, J, Fietze, I, Penzel, T, Ludka, O, Rodenstein, D, Masa, J, Bouloukaki, I, Schiza, S, Kent, B, Mcnicholas, W, Ryan, S, Riha, R, Schulz, R, Zou, D, Pepin, J, Levy, P, Bailly, S, Lavie, L, Lavie, P, Tasbakan, M, Varoneckas, G, Tkacova, R, Staats, R, Barbe, F, Lombardi, C, Parati, G, Drummond, M, van Zeller, M, Bonsignore, M, Petitjean, M, Pretl, M, Vitols, A, Dogas, Z, Galic, T, Pataka, A, Saaresranta, T, Plywaczewski, R, Sliwinski, P, Bielicki, P, Gunduz C., Basoglu O. K., Kvamme J. A., Verbraecken J., Anttalainen U., Marrone O., Steiropoulos P., Roisman G., Joppa P., Hein H., Trakada G., Hedner J., Grote L., Petiet E., Montserrat J. M., Fietze I., Penzel T., Ludka O., Rodenstein D., Masa J. F., Bouloukaki I., Schiza S., Kent B., McNicholas W. T., Ryan S., Riha R. L., Schulz R., Zou D., Pepin J. L., Levy P., Bailly S., Lavie L., Lavie P., Tasbakan M. S., Varoneckas G., Tkacova R., Staats R., Barbe F., Lombardi C., Parati G., Drummond M., van Zeller M., Bonsignore M. R., Petitjean M., Pretl M., Vitols A., Dogas Z., Galic T., Pataka A., Saaresranta T., Plywaczewski R., Sliwinski P., and Bielicki P.

Abstract

Background and aim: Obstructive sleep apnea (OSA) is an independent risk factor for dyslipidemia. The current study examined the effects of positive airway pressure (PAP) treatment on lipid status in the European Sleep Apnea Database (ESADA). Methods: The prospective cohort study enrolled 1564 OSA subjects (74% male, mean age 54 ± 11y, body mass index (BMI) 32.7 ± 6.6 kg/m2 and apnea-hypopnea index (AHI) 40.3 ± 24.4 n/h) undergoing PAP therapy for at least three months (mean 377.6 ± 419.5 days). Baseline and follow-up total cholesterol (TC) from nine centers were analyzed. Repeated measures and logistic regression tests (adjusted for age, sex, weight changes, lipid lowering medication, PAP compliance, and treatment duration) were used to compare changes in TC concentration. Incident risk for a coronary heart disease event (CHD) was used to compute a Framingham CHD risk score (estimated from age, BMI, blood pressure, and TC). Results: Adjusted means of TC decreased from 194.2 mg/dl to 189.3 mg/dl during follow-up (p = 0.019). A clinically significant (10%) reduction of TC at PAP follow-up was observed in 422 patients (27%). Duration of PAP therapy was identified as independent predictor for TC reduction, which implies an approximately 10% risk reduction for incident CHD events (from 26.7% to 24.1% in men and from 11.2% to 10.1% in women, p < 0.001 respectively). Conclusion: This observational study demonstrates a reduction of TC after long-term PAP treatment. The close association between TC concentration and cardiovascular (CV) mortality suggests that identification and treatment of OSA may have a beneficial effect on overall CV risk due to this mechanism. This possibility needs to be evaluated in prospective randomized studies.

Published
2020

10. Hyperlipidaemia prevalence and cholesterol control in obstructive sleep apnoea: Data from the European sleep apnea database (ESADA)

Author

Gunduz, C, Basoglu, O, Hedner, J, Bonsignore, M, Hein, H, Staats, R, Bouloukaki, I, Roisman, G, Pataka, A, Sliwinski, P, Ludka, O, Pepin, J, Grote, L, Steiropoulos, P, Verbraecken, J, Petiet, E, Trakada, G, Montserrat, J, Fietze, I, Penzel, T, Rodenstein, D, Masa, J, Schiza, S, Kent, B, Mcnicholas, W, Ryan, S, Riha, R, Kvamme, J, Schulz, R, Zou, D, Levy, P, Bailly, S, Lavie, L, Lavie, P, Tasbakan, M, Varoneckas, G, Joppa, P, Tkacova, R, Barbe, F, Lombardi, C, Parati, G, Drummond, M, van Zeller, M, Marrone, O, Petitjean, M, Pretl, M, Vitols, A, Dogas, Z, Galic, T, Anttalainen, U, Saaresranta, T, Plywaczewski, R, Bielicki, P, Gunduz C., Basoglu O. K., Hedner J., Bonsignore M. R., Hein H., Staats R., Bouloukaki I., Roisman G., Pataka A., Sliwinski P., Ludka O., Pepin J. L., Grote L., Steiropoulos P., Verbraecken J., Petiet E., Trakada G., Montserrat J. M., Fietze I., Penzel T., Rodenstein D., Masa J. F., Schiza S., Kent B., McNicholas W. T., Ryan S., Riha R. L., Kvamme J. A., Schulz R., Zou D., Levy P., Bailly S., Lavie L., Lavie P., Tasbakan M. S., Varoneckas G., Joppa P., Tkacova R., Barbe F., Lombardi C., Parati G., Drummond M., van Zeller M., Marrone O., Petitjean M., Pretl M., Vitols A., Dogas Z., Galic T., Anttalainen U., Saaresranta T., Plywaczewski R., Bielicki P., Gunduz, C, Basoglu, O, Hedner, J, Bonsignore, M, Hein, H, Staats, R, Bouloukaki, I, Roisman, G, Pataka, A, Sliwinski, P, Ludka, O, Pepin, J, Grote, L, Steiropoulos, P, Verbraecken, J, Petiet, E, Trakada, G, Montserrat, J, Fietze, I, Penzel, T, Rodenstein, D, Masa, J, Schiza, S, Kent, B, Mcnicholas, W, Ryan, S, Riha, R, Kvamme, J, Schulz, R, Zou, D, Levy, P, Bailly, S, Lavie, L, Lavie, P, Tasbakan, M, Varoneckas, G, Joppa, P, Tkacova, R, Barbe, F, Lombardi, C, Parati, G, Drummond, M, van Zeller, M, Marrone, O, Petitjean, M, Pretl, M, Vitols, A, Dogas, Z, Galic, T, Anttalainen, U, Saaresranta, T, Plywaczewski, R, Bielicki, P, Gunduz C., Basoglu O. K., Hedner J., Bonsignore M. R., Hein H., Staats R., Bouloukaki I., Roisman G., Pataka A., Sliwinski P., Ludka O., Pepin J. L., Grote L., Steiropoulos P., Verbraecken J., Petiet E., Trakada G., Montserrat J. M., Fietze I., Penzel T., Rodenstein D., Masa J. F., Schiza S., Kent B., McNicholas W. T., Ryan S., Riha R. L., Kvamme J. A., Schulz R., Zou D., Levy P., Bailly S., Lavie L., Lavie P., Tasbakan M. S., Varoneckas G., Joppa P., Tkacova R., Barbe F., Lombardi C., Parati G., Drummond M., van Zeller M., Marrone O., Petitjean M., Pretl M., Vitols A., Dogas Z., Galic T., Anttalainen U., Saaresranta T., Plywaczewski R., and Bielicki P.

Abstract

Background and objective: Obstructive sleep apnoea (OSA) and hyperlipidaemia are independent risk factors for cardiovascular disease. This study investigates the association between OSA and prevalence of hyperlipidaemia in patients of the European Sleep Apnea Database (ESADA) cohort. Methods: The cross-sectional analysis included 11 892 patients (age 51.9 ± 12.5 years, 70% male, body mass index (BMI) 31.3 ± 6.6 kg/m2, mean oxygen desaturation index (ODI) 23.7 ± 25.5 events/h) investigated for OSA. The independent odds ratio (OR) for hyperlipidaemia in relation to measures of OSA (ODI, apnoea-hypopnoea index, mean and lowest oxygen saturation) was determined by means of general linear model analysis with adjustment for important confounders such as age, BMI, comorbidities and study site. Results: Hyperlipidaemia prevalence increased from 15.1% in subjects without OSA to 26.1% in those with severe OSA, P < 0.001. Corresponding numbers in patients with diabetes were 8.5% and 41.5%, P < 0.001. Compared with ODI quartile I, patients in ODI quartiles II-IV had an adjusted OR (95% CI) of 1.33 (1.15–1.55), 1.37 (1.17–1.61) and 1.33 (1.12–1.58) (P < 0.001), respectively, for hyperlipidaemia. Obesity was defined as a significant risk factor for hyperlipidaemia. Subgroups of OSA patients with cardio-metabolic comorbidities demonstrated higher prevalence of HL. In addition, differences in hyperlipidaemia prevalence were reported in European geographical regions with the highest prevalence in Central Europe. Conclusion: Obstructive sleep apnoea, in particular intermittent hypoxia, was independently associated with the prevalence of hyperlipidaemia diagnosis.

Published
2019

11. Hyperlipidaemia prevalence and cholesterol control in obstructive sleep apnoea: Data from the European sleep apnea database (ESADA)

Author

Gunduz, C., Basoglu, O. Kacmaz, Hedner, J., Bonsignore, M. R., Hein, H., Staats, R., Bouloukaki, I, Roisman, G., Pataka, A., Sliwinski, P., Ludka, O., Pepin, J. L., Grote, L., Steiropoulos, P., Verbraecken, Johan, Petiet, E., Trakada, G., Montserrat, J. M., Fietze, I, Penzel, T., Ondrej, L., Rodenstein, D., Masa, J. F., Schiza, S., Kent, B., McNicholas, W. T., Ryan, S., Riha, R. L., Kvamme, J. A., Schulz, R., Zou, D., Pepina, J. L., Levy, P., Bailly, S., Lavie, L., Lavie, P., Basoglu, O. K., Tasbakan, M. S., Varoneckas, G., Joppa, P., Tkacova, R., Barbe, F., Lombardi, C., Parati, G., Drummond, M., van Zeller, M., Marrone, O., Petitjean, M., Pretl, M., Vitols, A., Dogas, Z., Galic, T., Anttalainen, U., Saaresranta, T., Plywaczewski, R., Bielicki, P., Gunduz, C, Basoglu, O, Hedner, J, Bonsignore, M, Hein, H, Staats, R, Bouloukaki, I, Roisman, G, Pataka, A, Sliwinski, P, Ludka, O, Pepin, J, Grote, L, Steiropoulos, P, Verbraecken, J, Petiet, E, Trakada, G, Montserrat, J, Fietze, I, Penzel, T, Rodenstein, D, Masa, J, Schiza, S, Kent, B, Mcnicholas, W, Ryan, S, Riha, R, Kvamme, J, Schulz, R, Zou, D, Levy, P, Bailly, S, Lavie, L, Lavie, P, Tasbakan, M, Varoneckas, G, Joppa, P, Tkacova, R, Barbe, F, Lombardi, C, Parati, G, Drummond, M, van Zeller, M, Marrone, O, Petitjean, M, Pretl, M, Vitols, A, Dogas, Z, Galic, T, Anttalainen, U, Saaresranta, T, Plywaczewski, R, Bielicki, P, Tıp Fakültesi, Gunduz C., Basoglu O.K., Hedner J., Bonsignore M.R., Hein H., Staats R., Bouloukaki I., Roisman G., Pataka A., Sliwinski P., Ludka O., Pepin J.L., Grote L., Steiropoulos P., Verbraecken J., Petiet E., Trakada G., Montserrat J.M., Fietze I., Penzel T., Rodenstein D., Masa J.F., Schiza S., Kent B., McNicholas W.T., Ryan S., Riha R.L., Kvamme J.A., Schulz R., Zou D., Levy P., Bailly S., Lavie L., Lavie P., Tasbakan M.S., Varoneckas G., Joppa P., Tkacova R., Barbe F., Lombardi C., Parati G., Drummond M., van Zeller M., Marrone O., Petitjean M., Pretl M., Vitols A., Dogas Z., Galic T., Anttalainen U., Saaresranta T., Plywaczewski R., Bielicki P., SALAS, Danielle, Biruni University [Istanbul] (BU), Ege university, University of Gothenburg (GU), Sahlgrenska University Hospital [Gothenburg], Università degli studi di Palermo - University of Palermo, CNR-IBIM : National Research Council-Institute of Biomedicine and Molecular Immunology, St. Adolf-Stift Hospital [Reinbek, Germany] (SASH), Hospital de Santa Maria [Lisboa], University of Crete [Heraklion] (UOC), AP-HP - Hôpital Antoine Béclère [Clamart], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), General Hospital of Thessaloniki George Papanikolaou, Institute of Tuberculosis and Lung Diseases [Warsaw, Poland] (ITLD), University Hospital Brno, St. Anne’s University Hospital [Brno], Hypoxie et PhysioPathologie (HP2), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Centre Hospitalier Universitaire [Grenoble] (CHU), European Sleep Apnoea Database collaborators: P Steiropoulos, J Verbraecken, E Petiet, G Trakada, J M Montserrat, I Fietze, T Penzel, D Rodenstein, J F Masa, S Schiza, B Kent, W T McNicholas, S Ryan, R L Riha, J A Kvamme, R Schulz, D Zou, J L Pépin, P Levy, S Bailly, L Lavie, P Lavie, M S Tasbakan, G Varoneckas, P Joppa, R Tkacova, F Barbé, C Lombardi, G Parati, M Drummond, M van Zeller, O Marrone, M Petitjean, M Pretl, A Vitols, Z Dogas, T Galic, U Anttalainen, T Saaresranta, R Plywaczewski, P Bielicki, and European Sleep Apnoea Database Col

Subjects
Male, 0301 basic medicine, [SDV]Life Sciences [q-bio], Polysomnography, Hyperlipidemias, Settore MED/10 - Malattie Dell'Apparato Respiratorio, 030204 cardiovascular system & hematology, computer.software_genre, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Diabetes mellitus, Prevalence, Internal Medicine, Humans, Medicine, cholesterol, hyperlipidaemia, hypoxia, obesity, sleep apnoea, Obesity, Sleep Apnea, Obstructive, Database, business.industry, Confounding, Sleep apnea, Odds ratio, Middle Aged, medicine.disease, respiratory tract diseases, [SDV] Life Sciences [q-bio], Europe, Cross-Sectional Studies, 030104 developmental biology, Quartile, Cardiovascular Diseases, Cohort, Female, Human medicine, business, Body mass index, computer
Abstract

Gunduz C, Basoglu OK, Hedner J, et al; onbehalf of the European Sleep Apnoea Databasecollaborators (Biruni University; Ege University;Gothenburg University; Sahlgrenska UniversityHospital; University of Palermo; CNR Institute ofBiomedicine and Molecular Immunology; St. AdolfStift; Hospital de Santa Maria; University of Crete;Antoine-Beclere Hospital; G. PapanikolaouHospital; Institute of Tuberculosis and LungDiseases; University Hospital Brno; St. Ann’sUniversity Hospital; Universite ́ Grenoble Alpes)Hyperlipidaemia prevalence and cholesterolcontrol in obstructive sleep apnoea: Data from theEuropean sleep apnea database (ESADA).J InternMed2019;286: 676–688.Background and objective.Obstructive sleep apnoea(OSA) and hyperlipidaemia are independent riskfactors for cardiovascular disease. This studyinvestigates the association between OSA andprevalence of hyperlipidaemia in patients of theEuropean Sleep Apnea Database (ESADA) cohort.Methods.The cross-sectional analysis included11 892 patients (age 51.9 12.5 years, 70% male,body mass index (BMI) 31.3 6.6 kg/m2, meanoxygen desaturation index (ODI) 23.7 25.5events/h) investigated for OSA. The independentodds ratio (OR) for hyperlipidaemia in relation tomeasures of OSA (ODI, apnoea-hypopnoea index,mean and lowest oxygen saturation) was deter-mined by means of general linear model analysiswith adjustment for important confounders suchas age, BMI, comorbidities and study site.Results.Hyperlipidaemia prevalence increased from15.1% in subjects without OSA to 26.1% in thosewith severe OSA,P

Published
2019
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14. Sleep apnoea management in Europe during the COVID-19 pandemic: data from the European Sleep Apnoea Database (ESADA)

Author

Grote L, McNicholas WT, Hedner J, ESADA collaborators (Anttalainen U, Saaresranta T, Basoglu OK, Gunduz C, Tasbakan S, Bouloukaki I, Schiza SE, Bonsignore MR, Marrone O, Petitjean M, Roisman G, Fietze I, Laharnar N, Penzel T, Zou D, Kent BD, Ryan S, Kvamme JA, Bailly S, Pepin J-L, Tamisier R, Lombardi C, Parati G, Pataka A, Plywaczewski R, Sliwinski P, Pretl M, Riha R, Staats R, Steiropoulos P, Joppa P, Verbraecken J, Petiet E, Trakada G, Ludka O, Buskova J, Hein H, Drummond M, van Zeller M, Dogas Z, Galic T, Gouveris H, Mihaicuta S, Randerath W, Herkenrath S, Fanfulla F, Testelmans D, Ege Üniversitesi, Grote L., McNicholas W.T., Hedner J., Anttalainen U., Saaresranta T., Basoglu O.K., Gunduz C., Tasbakan S., Bouloukaki I., Schiza S.E., Bonsignore M.R., Marrone O., Petitjean M., Roisman G., Fietze I., Laharnar N., Penzel T., Zou D., Kent B.D., Ryan S., Kvamme J.A., Bailly S., Pepin J.-L., Tamisier R., Lombardi C., Parati G., Pataka A., Plywaczewski R., Sliwinski P., Pretl M., Riha R., Staats R., Steiropoulos P., Joppa P., Verbraecken J., Petiet E., Trakada G., Ludka O., Buskova J., Hein H., Drummond M., van Zeller M., Dogas Z., Galic T., Gouveris H., Mihaicuta S., Randerath W., Herkenrath S., Fanfulla F., Testelmans D., Grote, L, Mcnicholas, W, Hedner, J, Anttalainen, U, Saaresranta, T, Basoglu, O, Gunduz, C, Tasbakan, S, Bouloukaki, I, Schiza, S, Bonsignore, M, Marrone, O, Petitjean, M, Roisman, G, Fietze, I, Laharnar, N, Penzel, T, Zou, D, Kent, B, Ryan, S, Kvamme, J, Bailly, S, Pepin, J, Tamisier, R, Lombardi, C, Parati, G, Pataka, A, Plywaczewski, R, Sliwinski, P, Pretl, M, Riha, R, Staats, R, Steiropoulos, P, Joppa, P, Verbraecken, J, Petiet, E, Trakada, G, Ludka, O, Buskova, J, Hein, H, Drummond, M, van Zeller, M, Dogas, Z, Galic, T, Gouveris, H, Mihaicuta, S, Randerath, W, Herkenrath, S, Fanfulla, F, and Testelmans, D

Subjects
Pulmonary and Respiratory Medicine, Pediatrics, medicine.medical_specialty, Databases, Factual, Polysomnography, medicine.medical_treatment, Pneumonia, Viral, Personnel Staffing and Scheduling, Disease, Covid, sleep laboratory, Betacoronavirus, 03 medical and health sciences, Sleep Apnea Syndrome, Sleep Apnea Syndromes, 0302 clinical medicine, Surveys and Questionnaires, mental disorders, Research Letter, medicine, Humans, cardiovascular diseases, 030212 general & internal medicine, Continuous positive airway pressure, Pandemics, Sleep Medicine Specialty, Continuous Positive Airway Pressure, medicine.diagnostic_test, Coronavirus Infection, SARS-CoV-2, business.industry, Sleep apnea, COVID-19, Atrial fibrillation, medicine.disease, Comorbidity, Obesity, Telemedicine, Europe, 030228 respiratory system, Heart failure, Coronavirus Infections, business, Delivery of Health Care, management
Abstract

Sleep disordered breathing (SDB) is highly prevalent with a male to female predominance of two to one, and is more common in middle-aged and elderly subjects [1]. Affected patients often present with comorbidities such as obesity, cardiovascular disease (systemic hypertension, heart failure, atrial fibrillation), and diabetes mellitus Type II [2]. The strong overlap between the profile for SDB patients and the identified risk factors for adverse outcomes of COVID-19 infection that include age, male gender, and cardio-metabolic comorbidity [3] suggest that SDB patients may benefit from effective therapy if confronted with COVID-19 infection [4].

Published
2020
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21. Sleep apnoea management in Europe during the COVID-19 pandemic – Data from the European Sleep Apnoea Database (ESADA)

Author

Grote, L. McNicholas, W.T. Hedner, J. Anttalainen, U. Saaresranta, T. Basoglu, O.K. Gunduz, C. Tasbakan, S. Bouloukaki, I. Schiza, S.E. Bonsignore, M.R. Marrone, O. Petitjean, M. Roisman, G. Fietze, I. Laharnar, N. Penzel, T. Hedner, J. Zou, D. Grote, L. Kent, B.D. McNicholas, W.T. Ryan, S. Kvamme, J.A. Bailly, S. Pépin, J.-L. Tamisier, R. Lombardi, C. Parati, G. Pataka, A. Plywaczewski, R. Sliwinski, P. Pretl, M. Riha, R. Staats, R. Steiropoulos, P. Joppa, P. Verbraecken, J. Petiet, E. Trakada, G. Ludka, O. Bušková, J. Hein, H. Drummond, M. van Zeller, M. Dogas, Z. Galic, T. Gouveris, H. Mihaicuta, S. Randerath, W. Herkenrath, S. Fanfulla, F. Testelmans, D. ESADA collaborators

Published
2020

22. Long-term positive airway pressure therapy is associated with reduced total cholesterol levels in patients with obstructive sleep apnea: data from the European Sleep Apnea Database (ESADA)

Author

Gunduz, C. Basoglu, O.K. Kvamme, J.A. Verbraecken, J. Anttalainen, U. Marrone, O. Steiropoulos, P. Roisman, G. Joppa, P. Hein, H. Trakada, G. Hedner, J. Grote, L. Steiropoulos, P. Verbraecken, J. Petiet, E. Montserrat, J.M. Fietze, I. Penzel, T. Ludka, O. Rodenstein, D. Masa, J.F. Bouloukaki, I. Schiza, S. Kent, B. McNicholas, W.T. Ryan, S. Riha, R.L. Kvamme, J.A. Hein, H. Schulz, R. Grote, L. Hedner, J. Zou, D. Pépin, J.L. Levy, P. Bailly, S. Lavie, L. Lavie, P. Basoglu, O.K. Tasbakan, M.S. Varoneckas, G. Joppa, P. Tkacova, R. Staats, R. Barbé, F. Lombardi, C. Parati, G. Drummond, M. van Zeller, M. Bonsignore, M.R. Petitjean, M. Roisman, G. Pretl, M. Vitols, A. Dogas, Z. Galic, T. Pataka, A. Anttalainen, U. Saaresranta, T. Plywaczewski, R. Sliwinski, P. Bielicki, P. the European Sleep Apnea Database collaborators

Abstract

Background and aim: Obstructive sleep apnea (OSA) is an independent risk factor for dyslipidemia. The current study examined the effects of positive airway pressure (PAP) treatment on lipid status in the European Sleep Apnea Database (ESADA). Methods: The prospective cohort study enrolled 1564 OSA subjects (74% male, mean age 54 ± 11y, body mass index (BMI) 32.7 ± 6.6 kg/m2 and apnea-hypopnea index (AHI) 40.3 ± 24.4 n/h) undergoing PAP therapy for at least three months (mean 377.6 ± 419.5 days). Baseline and follow-up total cholesterol (TC) from nine centers were analyzed. Repeated measures and logistic regression tests (adjusted for age, sex, weight changes, lipid lowering medication, PAP compliance, and treatment duration) were used to compare changes in TC concentration. Incident risk for a coronary heart disease event (CHD) was used to compute a Framingham CHD risk score (estimated from age, BMI, blood pressure, and TC). Results: Adjusted means of TC decreased from 194.2 mg/dl to 189.3 mg/dl during follow-up (p = 0.019). A clinically significant (10%) reduction of TC at PAP follow-up was observed in 422 patients (27%). Duration of PAP therapy was identified as independent predictor for TC reduction, which implies an approximately 10% risk reduction for incident CHD events (from 26.7% to 24.1% in men and from 11.2% to 10.1% in women, p < 0.001 respectively). Conclusion: This observational study demonstrates a reduction of TC after long-term PAP treatment. The close association between TC concentration and cardiovascular (CV) mortality suggests that identification and treatment of OSA may have a beneficial effect on overall CV risk due to this mechanism. This possibility needs to be evaluated in prospective randomized studies. © 2020 Elsevier B.V.

Published
2020

26. Effect Of Tumor Treating Fields And Radiotherapy Combination On Brain Tumor And Normal Brain Cell Lines

Author

Yalman, D., primary, Koylu, M., additional, Kayabasi, C., additional, Kamer, S., additional, Ozkan, E., additional, Yelken, B. Ozmen, additional, Tayfur, E., additional, Celebi, C., additional, Bilge, M.D., additional, Susluer, S. Yilmaz, additional, Parlak, C., additional, Bilge, M., additional, Anacak, Y., additional, and Gunduz, C., additional

Published
2020
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32. The effects of the different centrifugal gravities on the cell viability

Author

Asik, A., Ay, N. Ozates, Kayabasi, C., Yelken, B. Ozmen, Sogutlu, F., Gasimli, R., Gunduz, C., and Ege Üniversitesi

Abstract

51st Conference of the European-Society-of-Human-Genetics (ESHG) in conjunction with the European Meeting on Psychosocial Aspects of Genetics (EMPAG) -- JUN 16-19, 2018 -- Milan, ITALY, Avci, Cigir Biray/0000-0001-8251-4520, WOS: 000489313107340, [No abstract available], European Soc Human Genet

Published
2019

33. Comparative effects of Dasatinib and Ponatinib on lncRNA expression in Chronic Myeloid Leukemia

Author

Kayabasi, C., Susluer, S. Yilmaz, Okcanoglu, T. Balci, Yelken, B. Ozmen, Asik, A., Mutlu, Z., Gunduz, C., and Ege Üniversitesi

Abstract

52nd Conference of the European-Society-of-Human-Genetics (ESHG) -- JUN 15-18, 2019 -- Gothenburg, SWEDEN, Avci, Cigir Biray/0000-0001-8251-4520, WOS: 000489313906033, [No abstract available], European Soc Human Genet

Published
2019

34. The effects of the therapeutic agents Ponatinib and VS-5584 on Chronic Myeloid Leukemia leukemogenesis

Author

Kayabasi, C., Yelken, B. Ozmen, Asik, A., Okcanoglu, T. Balci, Sogutlu, F., Gasimli, R., Gunduz, C., and Ege Üniversitesi

Abstract

51st Conference of the European-Society-of-Human-Genetics (ESHG) in conjunction with the European Meeting on Psychosocial Aspects of Genetics (EMPAG) -- JUN 16-19, 2018 -- Milan, ITALY, Avci, Cigir Biray/0000-0001-8251-4520, WOS: 000489313103178, [No abstract available], European Soc Human Genet

Published
2019

36. Ruxolitinib regulates energy metabolism of multiple myeloma cells

Author

Avci, C. Biray, Bagca, B. Goker, Ay, N. Ozates, Kusoglu, A., Abbaszade, Z., Cesmeli, S., Gunduz, C., and Ege Üniversitesi

Abstract

52nd Conference of the European-Society-of-Human-Genetics (ESHG) -- JUN 15-18, 2019 -- Gothenburg, SWEDEN, Avci, Cigir Biray/0000-0001-8251-4520, WOS: 000489313904180, [No abstract available], European Soc Human Genet

Published
2019

37. The in-vitro evaluation of anticancer effect of DMU-212, a novel resveratrol analog, on prostate cancer cells

Author

Yelken, B. Ozmen, Kayabasi, C., Asik, A., Okcanoglu, T. Balci, Sogutlu, F., Gasimli, R., Gunduz, C., and Ege Üniversitesi

Abstract

51st Conference of the European-Society-of-Human-Genetics (ESHG) in conjunction with the European Meeting on Psychosocial Aspects of Genetics (EMPAG) -- JUN 16-19, 2018 -- Milan, ITALY, Avci, Cigir Biray/0000-0001-8251-4520, WOS: 000489313104059, [No abstract available], European Soc Human Genet

Published
2019

38. Ruxolitinib regulates mechanisms of apoptosis and autophagy in multiple myeloma cells

Author

Kusoglu, A., Bagca, B. Goker, Ay, N. Ozates, Avci, C. Biray, Gunduz, C., Saydam, G., and Ege Üniversitesi

Abstract

52nd Conference of the European-Society-of-Human-Genetics (ESHG) -- JUN 15-18, 2019 -- Gothenburg, SWEDEN, Avci, Cigir Biray/0000-0001-8251-4520, WOS: 000489313904153, [No abstract available], European Soc Human Genet, Ege University Scientific Research Projects CoordinationEge University, Our study is supported by Ege University Scientific Research Projects Coordination.

Published
2019

39. Important Effect of BIBR1532 and Rapamycin Combination on Breast Cancer Stem Cells

Author

Avci, C. Biray, Dogan, F., Ozates, N., Bagca, B. Goker, Gunduz, C., and Ege Üniversitesi

Abstract

51st Conference of the European-Society-of-Human-Genetics (ESHG) in conjunction with the European Meeting on Psychosocial Aspects of Genetics (EMPAG) -- JUN 16-19, 2018 -- Milan, ITALY, Avci, Cigir Biray/0000-0001-8251-4520, WOS: 000489313103170, [No abstract available], European Soc Human Genet

Published
2019

42. Telomerase inhibiton in glioma cells: Epigenetic reflections to therapy

Author

Avci, G. Biray, Dogan, F., Abbaszadeh, Z., Goker, B., Kurt, C. Caliskan, Ozates, N., Gunduz, C., and Ege Üniversitesi

Subjects
[No Keyword]
Abstract

50th European-Society-of-Human-Genetics (ESHG) Conference -- MAY 27-30, 2017 -- Copenhagen, DENMARK, MUTLU, Zeynep/0000-0003-3722-4430, WOS:000489312606252, [No Abstract Available], European Soc Human Genet

Published
2018

43. ULTRASONIC PRE-TREATMENT OF WASTEWATER SLUDGE FROM A MEAT PROCESSING

Author

Filibeli, A, Erden, G, and Gunduz, C

Subjects
Anaerobic biodegradability, Biochemical methane potential, Filterability, Floc disintegration, Meat processing wastewater
Abstract

This investigation deals with ultrasonic disintegration of sludge taken from a meat processing wastewater treatment plant. Different specific energy inputs ranging between 0 and 100 MJ/kg Total Solids (TS) were used in the study. The effect of ultrasonic pre-treatment on anaerobic biodegradability and filterability characteristics of sludge were evaluated using lab-scale experiments. 30 MJ/kg TS of supplied energy is efficient for cell lyses. Ultrasonic pre-treatment significantly enhanced the biodegradability of sludge. Biochemical methane potential test results also supported this result. For 30 MJ/kg TS, 2.4 times higher methane production was achieved compared to raw sludge. Sludge's supernatant characteristics were also affected by the ultrasonic pre-treatment. For 30 MJ/kg TS, oil content, total nitrogen and total phosphorus in the sludge supernatant increased by 3.8 times, 58 times, and 12 times, respectively. The other result is that ultrasonic treatment adversely affected filterability characteristics of sludge even for very low specific energy levels.

Published
2018

44. Effect of resveratrol on apoptosis and MDM2, RUNX3, RB gene expressions in human acute myeloid leukemia cells by transfection of MATRA-mediated miR-150 [MATRA aracılı miR-150’nin transfeksiyonu ile insan akut myeloid lösemi hücrelerinde resveratrol’ün MDM2,RUNX3,RB gen ekspresyonları ve apoptoz üzerine etkisi]

Author

Okcanoglu T.B., Susluer S.Y., Kayabasi C., Yelken B.O., Saydam G., Avci C.B., Gunduz C., and Ege Üniversitesi

Subjects
Acute myeloid leukemia, miR-150, Resveratrol, Gene expressions, MATRA
Abstract

2-s2.0-85054491647, Acute myeloid leukemia (AML) is a heterogeneous group of hematopoietic malignancies. Magnet assisted transfection (MATRA) is one of the most effective non-viral transfection methods. We aimed to evaluate the apoptotic effect of resveratrol (RES), MDM2, RUNX3, RB gene expression exchanges and MicroRNA-150 (miR-150) transfected with MATRA to HL-60 cells. MATRA was used as non-viral vector carrier for miR-150 transfection. IC50 dose of RES was determineted by Fahri et al. Resveratrol and miR-150 transfected cells were performed apoptosis and MDM2, RUNX3, RB gene expression assays in Human promyelocytic leukemia (HL-60) cells. IC50 dose of RES was used as 5 ?M. In HL-60 cells, it was found that miR-150, miR150-Resveratrol combination, resveratrol alone induces apoptosis by 6.48, 6.93 and 4.54 fold, respectively, compared to the control cells. Compared to control cells, MDM2, RUNX3, RB, gene expressions decreased (miR-150) 1.7, 1.3 and 1.4 fold, (miR-150-resveratrol) MDM2 expression increased 2.73 fold, RUNX3 and RB expression decreased 6.1, 1.07 fold, respectively. Combination with resveratrol, MDM2, RB decreased 2.9 and 1.4 fold, respectively. Non-viral miR-150 transfection may be effective in leukemia cells, induction of apoptotic effects and gene expression changes, following treatment with resveratrol and miR-150-resveratrol combinations. © 2018, UHOD - Uluslararasi Hematoloji Onkoloji Dergisi. All rights reserved., No financial support was received in this study.

Published
2018

47. EXAMINING THE PERCEPTION OF QUALITY AND CUSTOMER SATISFACTION WITHIN THE

Author

Gunduz, GS and Gunduz, C

Subjects
Total Quality Management, Quality, Customer Satisfaction, Customer, Expectations, Textile Industry
Abstract

Today, meeting customer expectations is very important for firms to survive in the competitive market. Quality production features Total Quality Management (TQM) that becomes increasingly interesting topic in recent years. The goal of this study is to investigate the quality and customer satisfaction perceptions of textile firms operating in Denizli within the framework of TQM and to reveal differences between these enterprises which implement TQM and those do not. Also, the reasons for firms to perform or not to perform TQM practices, things required to be done for meeting customer expectations, some problems for firms which they met during the implementation of TQM and expectations of textile firms from other companies that they will work together have been explained. SPSS for Windows 16.0 package program is used for evaluating data. As a result, it is seen that TQM practices have a positive impact on quality and customer satisfaction.

Published
2017

48. Anti-cancer efficiency of natural killer cells differentiated from human adipose tissue-derived mesenchymal stem cells and transfected with miRNA150

Author

Karlitepe, A. and Kabadayi, H. and Vatansever, S. and Gurdal, M. and Gunduz, C. and Ercan, G., Department of Medical Biochemistry, Ege University Medical School, Izmir, 35100, Turkey, Department of Histology and Embryology, Celal Bayar University Medical School, Manisa, 45030, Turkey, Experimental Health Sciences Research Center, Near East University, Mersin, 33010, Turkey, Department of Medical Biology, Ege University School of Medicine, Izmir, 35100, Turkey, and Department of Stem Cell, Ege University Institute of Health Sciences, Izmir, 35100, Turkey

Subjects
animal structures, viruses, fungi, embryonic structures
Abstract

Aim: The aim of this study is to investigate the effects of miR150 transfection on NK-like cells differentiated from adipose tissue derived mesenchymal stem cells (AD-MSCs). Methods: NK-like cells were differentiated from AD-MSCs and activated by miR150 transfection. Transfected/non-Transfected NK-like cells were characterized by immunohistochemical and RTPCR analyzes. Apoptotic efficiency of the transfected/non-Transfected NK-like cells on pancreatic cancer cells PANC1 were determined by TUNEL and RT-PCR. Results: In miR150-Transfected cells, the increased expression of NK cell-specific genes such as GKMB, KIR2DL2, CD16, CD56, NKG2D, NKp46 and increased immunoreactivity of NK cell-specific surface marker CD314 (NKG2D) were evident. TUNEL assays showed that NK-like cells with/without transfection induced apoptosis in PANC1 cells in the same manner. The decrease in oncogene expression and the increase in the tumor suppressor gene expression in PANC1 cells upon co-culture with NK-like cells differentiated from AD-MSCs were more prominent following miRNA150 transfection. Conclusion: It was shown in vitro that NK-like cells could be obtained by differentiation from AD-MSCs and their efficiency could be increased via miR150 transfection. The results are encouraging for further clinical studies in improvement of immunotherapeutic approaches for cancer therapy. Copyright © Experimental Oncology, 2017.

Published
2017

49. Yeast biota of naturally fermented black olives in different brines made from cv. Gemlik grown in various districts of the Cukurova region of Turkey

Author

Leventdurur, Sezgi, Sert-Aydin, Selvihan, Boyaci-Gunduz, C. Pelin, Agirman, Bilal, Ben Ghorbal, Akram, Francesca, Nicola, Martorana, Alessandra, Erten, Huseyin, Leventdurur, S., Sert-Aydın, S., Boyaci-Gunduz, C., Agirman, B., Ben Ghorbal, A., Francesca, N., Martorana, A., and Erten, H.

Subjects
Turkey, Microbiota, Gemlik, molecular, NaCl, PCR, table olive, yeast, Biochemistry, Biotechnology, Genetics, Bioengineering, Applied Microbiology and Biotechnology, Biodiversity, Genetic, Olea, Yeasts, Fermentation, Settore AGR/16 - Microbiologia Agraria
Abstract

In this study, the yeast microbiota of naturally fermented black olives made from cv. Gemlik, grown in three different districts of the Cukurova region of Turkey, were investigated. Fermentations were conducted for 180days in three different brines, including NaCl 10% w/v, NaCl 8% w/v and NaCl 8% w/v added with glucose 0.5%. In total, 223 yeasts were isolated and then identified by PCR-RFLP analysis of the 5.8S ITS rRNA region and sequence information for the D1/D2 domains of the 26S rRNA gene. A broad range of yeast biodiversity was identified, including eight genera and nine species. Candida boidinii (41%), Wickerhamomyces anomalus (32%) and Saccharomyces sp. (18%) were predominant yeasts throughout the fermentations. To a lesser extent, the other species, Candida aaseri, Meyerozyma sp., Zygoascus hellenicus, Pichia kudriavzevii, Schwanniomyces etchellsii and Candida atlantica were also members of the olive-fermenting microbiota. In Tarsus and Bahce districts C. boidinii and in Serinyol district Saccharomyces sp. were the most frequently identified species. W. anomalus was the most frequently isolated species (by 48% of total yeasts) in NaCl 10% brines. C. boidinii was the most dominant species in the brines, including NaCl 8% and NaCl 8%+glucose 0.5%, with frequencies of 42% and 61%, respectively. At the end of the 180days of fermentation, total acidity values of the brines were in the range 1.04-8.1g/l lactic acid. Copyright (c) 2016 John Wiley & Sons, Ltd.

Published
2015

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