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4. Additional file 4: Table S3. of Tumour stage distribution and survival of malignant melanoma in Germany 2002–2011

Author

Schoffer, Olaf, Schülein, Stefanie, Arand, Gerlinde, Arnholdt, Hans, Baaske, Dieter, Bargou, Ralf, Becker, Nikolaus, Beckmann, Matthias, Bodack, Yves, Böhme, Beatrix, Bozkurt, Tayfun, Breitsprecher, Regine, Buchali, Andre, Burger, Elke, Burger, Ulrike, Dommisch, Klaus, Elsner, Gudrun, Fernschild, Karin, Flintzer, Ulrike, Funke, Uwe, Gerken, Michael, Göbel, Hubert, Grobe, Norbert, Gumpp, Vera, Heinzerling, Lucie, Kempfer, Lana, Kiani, Alexander, Klinkhammer-Schalke, Monika, Klöcking, Sabine, Kreibich, Ute, Knabner, Katrin, Kuhn, Peter, Lutze, Stine, Mäder, Uwe, Maisel, Tanja, Maschke, Jan, Middeke, Martin, Neubauer, Andreas, Niedostatek, Antje, Opazo-Saez, Anabelle, Peters, Christoph, Schell, Beatrice, Schenkirsch, Gerhard, Schmalenberg, Harald, Schmidt, Peter, Schneider, Constanze, Schubotz, Birgit, Seide, Anika, Strecker, Paul, Taubenheim, Sabine, Wackes, Matthias, Weiß, Steffen, Welke, Claudia, Werner, Carmen, Wittekind, Christian, Wulff, Jörg, Zettl, Heike, and Klug, Stefanie

Subjects
respiratory system, digestive system diseases
Abstract

Relative 5-year survival of malignant melanoma patients diagnosed between 2002 and 2011, overall (UICC 0-IV, X) (N = 60 672) and for patients with invasive tumours (UICC I – IV, X) stratified by age, sex, UICC stage, ‘diagnosis during screening’ and place of residence (N = 49 351) (DOCX 39 kb)

Published
2016
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5. Additional file 2: Table S1. of Tumour stage distribution and survival of malignant melanoma in Germany 2002–2011

Author

Schoffer, Olaf, Schülein, Stefanie, Arand, Gerlinde, Arnholdt, Hans, Baaske, Dieter, Bargou, Ralf, Becker, Nikolaus, Beckmann, Matthias, Bodack, Yves, Böhme, Beatrix, Bozkurt, Tayfun, Breitsprecher, Regine, Buchali, Andre, Burger, Elke, Burger, Ulrike, Dommisch, Klaus, Elsner, Gudrun, Fernschild, Karin, Flintzer, Ulrike, Funke, Uwe, Gerken, Michael, Göbel, Hubert, Grobe, Norbert, Gumpp, Vera, Heinzerling, Lucie, Kempfer, Lana, Kiani, Alexander, Klinkhammer-Schalke, Monika, Klöcking, Sabine, Kreibich, Ute, Knabner, Katrin, Kuhn, Peter, Lutze, Stine, Mäder, Uwe, Maisel, Tanja, Maschke, Jan, Middeke, Martin, Neubauer, Andreas, Niedostatek, Antje, Opazo-Saez, Anabelle, Peters, Christoph, Schell, Beatrice, Schenkirsch, Gerhard, Schmalenberg, Harald, Schmidt, Peter, Schneider, Constanze, Schubotz, Birgit, Seide, Anika, Strecker, Paul, Taubenheim, Sabine, Wackes, Matthias, Weiß, Steffen, Welke, Claudia, Werner, Carmen, Wittekind, Christian, Wulff, Jörg, Zettl, Heike, and Klug, Stefanie

Subjects
respiratory system, digestive system diseases
Abstract

pT stage by UICC Stage of malignant melanoma patients diagnosed between 2002 and 2011 (N = 61 895) (DOCX 38 kb)

Published
2016
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6. Additional file 3: Table S2. of Tumour stage distribution and survival of malignant melanoma in Germany 2002–2011

Author

Schoffer, Olaf, Schülein, Stefanie, Arand, Gerlinde, Arnholdt, Hans, Baaske, Dieter, Bargou, Ralf, Becker, Nikolaus, Beckmann, Matthias, Bodack, Yves, Böhme, Beatrix, Bozkurt, Tayfun, Breitsprecher, Regine, Buchali, Andre, Burger, Elke, Burger, Ulrike, Dommisch, Klaus, Elsner, Gudrun, Fernschild, Karin, Flintzer, Ulrike, Funke, Uwe, Gerken, Michael, Göbel, Hubert, Grobe, Norbert, Gumpp, Vera, Heinzerling, Lucie, Kempfer, Lana, Kiani, Alexander, Klinkhammer-Schalke, Monika, Klöcking, Sabine, Kreibich, Ute, Knabner, Katrin, Kuhn, Peter, Lutze, Stine, Mäder, Uwe, Maisel, Tanja, Maschke, Jan, Middeke, Martin, Neubauer, Andreas, Niedostatek, Antje, Opazo-Saez, Anabelle, Peters, Christoph, Schell, Beatrice, Schenkirsch, Gerhard, Schmalenberg, Harald, Schmidt, Peter, Schneider, Constanze, Schubotz, Birgit, Seide, Anika, Strecker, Paul, Taubenheim, Sabine, Wackes, Matthias, Weiß, Steffen, Welke, Claudia, Werner, Carmen, Wittekind, Christian, Wulff, Jörg, Zettl, Heike, and Klug, Stefanie

Subjects
respiratory system, digestive system diseases
Abstract

Malignant melanoma patients aged 35 years and above by age at diagnosis, sex, UICC stage, year of diagnosis, place of residence and ‘diagnosis during screening’, N = 34 739 (UICC 0 and X excluded) (DOCX 40 kb)

Published
2016
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7. Tumour stage distribution and survival of malignant melanoma in Germany 2002-2011

Author

Schoffer, Olaf, Schülein, Stefanie, Arand, Gerlinde, Arnholdt, Hans, Baaske, Dieter, Bargou, Ralf C., Becker, Nikolaus, Beckmann, Matthias W., Bodack, Yves, Böhme, Beatrix, Bozkurt, Tayfun, Breitsprecher, Regine, Buchali, Andre, Burger, Elke, Burger, Ulrike, Dommisch, Klaus, Elsner, Gudrun, Fernschild, Karin, Flintzer, Ulrike, Funke, Uwe, Gerken, Michael, Göbel, Hubert, Grobe, Norbert, Gumpp, Vera, Heinzerling, Lucie, Kempfer, Lana Raffaela, Kiani, Alexander, Klinkhammer-Schalke, Monika, Klöcking, Sabine, Kreibich, Ute, Knabner, Katrin, Kuhn, Peter, Lutze, Stine, Mäder, Uwe, Maisel, Tanja, Maschke, Jan, Middeke, Martin, Neubauer, Andreas, Niedostatek, Antje, Opazo-Saez, Anabelle, Peters, Christoph, Schell, Beatrice, Schenkirsch, Gerhard, Schmalenberg, Harald, Schmidt, Peter, Schneider, Constanze, Schubotz, Birgit, Seide, Anika, Strecker, Paul, Taubenheim, Sabine, Wackes, Matthias, Weiß, Steffen, Welke, Claudia, Werner, Carmen, Wittekind, Christian, Wulff, Jörg, Zettl, Heike, and Klug, Stefanie J.

Subjects
Adult, Male, Cancer Research, Time Factors, Adolescent, TNM staging, Young Adult, Skin cancer screening, Medizinische Fakultät, Germany, Genetics, Humans, Registries, ddc:610, Melanoma, Aged, Neoplasm Staging, Aged, 80 and over, Malignant melanoma, Incidence, Middle Aged, Survival analysis, Prognosis, Survival Rate, Oncology, Female, Stage distribution, Follow-Up Studies, Research Article
Abstract

Background Over the past two decades, there has been a rising trend in malignant melanoma incidence worldwide. In 2008, Germany introduced a nationwide skin cancer screening program starting at age 35. The aims of this study were to analyse the distribution of malignant melanoma tumour stages over time, as well as demographic and regional differences in stage distribution and survival of melanoma patients. Methods Pooled data from 61 895 malignant melanoma patients diagnosed between 2002 and 2011 and documented in 28 German population-based and hospital-based clinical cancer registries were analysed using descriptive methods, joinpoint regression, logistic regression and relative survival. Results The number of annually documented cases increased by 53.2% between 2002 (N = 4 779) and 2011 (N = 7 320). There was a statistically significant continuous positive trend in the proportion of stage UICC I cases diagnosed between 2002 and 2011, compared to a negative trend for stage UICC II. No trends were found for stages UICC III and IV respectively. Age (OR 0.97, 95% CI 0.97–0.97), sex (OR 1.18, 95% CI 1.11–1.25), date of diagnosis (OR 1.05, 95% CI 1.04–1.06), ‘diagnosis during screening’ (OR 3.24, 95% CI 2.50–4.19) and place of residence (OR 1.23, 95% CI 1.16–1.30) had a statistically significant influence on the tumour stage at diagnosis. The overall 5-year relative survival for invasive cases was 83.4% (95% CI 82.8–83.9%). Conclusions No distinct changes in the distribution of malignant melanoma tumour stages among those aged 35 and older were seen that could be directly attributed to the introduction of skin cancer screening in 2008. Electronic supplementary material The online version of this article (doi:10.1186/s12885-016-2963-0) contains supplementary material, which is available to authorized users.

Published
2016

8. Tumour stage distribution and survival of malignant melanoma in Germany 2002–2011

Author

Schoffer, Olaf, Schülein, Stefanie, Arand, Gerlinde, Arnholdt, Hans, Baaske, Dieter, Bargou, Ralf C., Becker, Nikolaus, Beckmann, Matthias W., Bodack, Yves, Böhme, Beatrix, Bozkurt, Tayfun, Breitsprecher, Regine, Buchali, Andre, Burger, Elke, Burger, Ulrike, Dommisch, Klaus, Elsner, Gudrun, Fernschild, Karin, Flintzer, Ulrike, Funke, Uwe, Gerken, Michael, Göbel, Hubert, Grobe, Norbert, Gumpp, Vera, Heinzerling, Lucie, Kempfer, Lana Raffaela, Kiani, Alexander, Klinkhammer-Schalke, Monika, Klöcking, Sabine, Kreibich, Ute, Knabner, Katrin, Kuhn, Peter, Lutze, Stine, Mäder, Uwe, Maisel, Tanja, Maschke, Jan, Middeke, Martin, Neubauer, Andreas, Niedostatek, Antje, Opazo-Saez, Anabelle, Peters, Christoph, Schell, Beatrice, Schenkirsch, Gerhard, Schmalenberg, Harald, Schmidt, Peter, Schneider, Constanze, Schubotz, Birgit, Seide, Anika, Strecker, Paul, Taubenheim, Sabine, Wackes, Matthias, Weiß, Steffen, Welke, Claudia, Werner, Carmen, Wittekind, Christian, Wulff, Jörg, Zettl, Heike, and Klug, Stefanie J.

Subjects
ddc
Published
2015

9. Tumour stage distribution and survival of malignant melanoma in Germany 2002–2011

Author

Schoffer, Olaf, primary, Schülein, Stefanie, additional, Arand, Gerlinde, additional, Arnholdt, Hans, additional, Baaske, Dieter, additional, Bargou, Ralf C., additional, Becker, Nikolaus, additional, Beckmann, Matthias W., additional, Bodack, Yves, additional, Böhme, Beatrix, additional, Bozkurt, Tayfun, additional, Breitsprecher, Regine, additional, Buchali, Andre, additional, Burger, Elke, additional, Burger, Ulrike, additional, Dommisch, Klaus, additional, Elsner, Gudrun, additional, Fernschild, Karin, additional, Flintzer, Ulrike, additional, Funke, Uwe, additional, Gerken, Michael, additional, Göbel, Hubert, additional, Grobe, Norbert, additional, Gumpp, Vera, additional, Heinzerling, Lucie, additional, Kempfer, Lana Raffaela, additional, Kiani, Alexander, additional, Klinkhammer-Schalke, Monika, additional, Klöcking, Sabine, additional, Kreibich, Ute, additional, Knabner, Katrin, additional, Kuhn, Peter, additional, Lutze, Stine, additional, Mäder, Uwe, additional, Maisel, Tanja, additional, Maschke, Jan, additional, Middeke, Martin, additional, Neubauer, Andreas, additional, Niedostatek, Antje, additional, Opazo-Saez, Anabelle, additional, Peters, Christoph, additional, Schell, Beatrice, additional, Schenkirsch, Gerhard, additional, Schmalenberg, Harald, additional, Schmidt, Peter, additional, Schneider, Constanze, additional, Schubotz, Birgit, additional, Seide, Anika, additional, Strecker, Paul, additional, Taubenheim, Sabine, additional, Wackes, Matthias, additional, Weiß, Steffen, additional, Welke, Claudia, additional, Werner, Carmen, additional, Wittekind, Christian, additional, Wulff, Jörg, additional, Zettl, Heike, additional, and Klug, Stefanie J., additional

Published
2016
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10. Tumour stage distribution and survival of malignant melanoma in Germany 2002–2011

Author

Schoffer, Olaf;Schülein, Stefanie;Arand, Gerlinde;Arnholdt, Hans;Baaske, Dieter;Bargou, Ralf C.;Becker, Nikolaus;Beckmann, Matthias W.;Bodack, Yves;Böhme, Beatrix;Bozkurt, Tayfun;Breitsprecher, Regine;Buchali, Andre;Burger, Elke;Burger, Ulrike;Dommisch, Klaus;Elsner, Gudrun;Fernschild, Karin;Flintzer, Ulrike;Funke, Uwe;Gerken, Michael;Göbel, Hubert;Grobe, Norbert;Gumpp, Vera;Heinzerling, Lucie;Kempfer, Lana Raffaela;Kiani, Alexander;Klinkhammer-Schalke, Monika;Klöcking, Sabine;Kreibich, Ute;Knabner, Katrin;Kuhn, Peter;Lutze, Stine;Mäder, Uwe;Maisel, Tanja;Maschke, Jan;Middeke, Martin;Neubauer, Andreas;Niedostatek, Antje;Opazo-Saez, Anabelle;Peters, Christoph;Schell, Beatrice;Schenkirsch, Gerhard;Schmalenberg, Harald;Schmidt, Peter;Schneider, Constanze;Schubotz, Birgit;Seide, Anika;Strecker, Paul;Taubenheim, Sabine;Wackes, Matthias;Weiß, Steffen;Welke, Claudia;Werner, Carmen;Wittekind, Christian;Wulff, Jörg;Zettl, Heike;Klug, Stefanie J. and Schoffer, Olaf;Schülein, Stefanie;Arand, Gerlinde;Arnholdt, Hans;Baaske, Dieter;Bargou, Ralf C.;Becker, Nikolaus;Beckmann, Matthias W.;Bodack, Yves;Böhme, Beatrix;Bozkurt, Tayfun;Breitsprecher, Regine;Buchali, Andre;Burger, Elke;Burger, Ulrike;Dommisch, Klaus;Elsner, Gudrun;Fernschild, Karin;Flintzer, Ulrike;Funke, Uwe;Gerken, Michael;Göbel, Hubert;Grobe, Norbert;Gumpp, Vera;Heinzerling, Lucie;Kempfer, Lana Raffaela;Kiani, Alexander;Klinkhammer-Schalke, Monika;Klöcking, Sabine;Kreibich, Ute;Knabner, Katrin;Kuhn, Peter;Lutze, Stine;Mäder, Uwe;Maisel, Tanja;Maschke, Jan;Middeke, Martin;Neubauer, Andreas;Niedostatek, Antje;Opazo-Saez, Anabelle;Peters, Christoph;Schell, Beatrice;Schenkirsch, Gerhard;Schmalenberg, Harald;Schmidt, Peter;Schneider, Constanze;Schubotz, Birgit;Seide, Anika;Strecker, Paul;Taubenheim, Sabine;Wackes, Matthias;Weiß, Steffen;Welke, Claudia;Werner, Carmen;Wittekind, Christian;Wulff, Jörg;Zettl, Heike;Klug, Stefanie J.

Published
2015

14. Inhibitor of differentiation proteins do not influence prognosis of biliary tract cancer.

Author

Harder J, Müller MJ, Fuchs M, Gumpp V, Schmitt-Graeff A, Fischer R, Frank M, Opitz O, and Hasskarl J

Subjects
Adult, Aged, Aged, 80 and over, Bile Duct Neoplasms pathology, Bile Duct Neoplasms therapy, Bile Ducts, Extrahepatic pathology, Bile Ducts, Intrahepatic pathology, Cholangiocarcinoma pathology, Cholangiocarcinoma therapy, Female, Gallbladder Neoplasms pathology, Gallbladder Neoplasms therapy, Humans, Immunohistochemistry, Inhibitor of Differentiation Protein 1 analysis, Inhibitor of Differentiation Protein 2 analysis, Kaplan-Meier Estimate, Male, Middle Aged, Multivariate Analysis, Neoplasm Grading, Neoplasm Proteins analysis, Neoplasm Staging, Predictive Value of Tests, Proportional Hazards Models, Retrospective Studies, Risk Factors, Time Factors, Treatment Outcome, Bile Duct Neoplasms chemistry, Bile Ducts, Extrahepatic chemistry, Bile Ducts, Intrahepatic chemistry, Cholangiocarcinoma chemistry, Gallbladder Neoplasms chemistry, Inhibitor of Differentiation Proteins analysis
Abstract

Aim: To investigate the expression and clinical relevance of inhibitor of differentiation (ID) proteins in biliary tract cancer., Methods: ID protein expression was analyzed in 129 samples from patients with advanced biliary tract cancer (BTC) (45 extrahepatic, 50 intrahepatic, and 34 gallbladder cancers), compared to normal controls and correlated with clinical an pathological parameters., Results: ID1-3 proteins are frequently overexpressed in all BTC subtypes analyzed. No correlation between increased ID protein expression and tumor grading, tumor subtype or treatment response was detected. Survival was influenced primary tumor localization (extrahepatic vs intrahepatic and gall bladder cancer, OS 1.5 years vs 0.9 years vs 0.7 years, P = 0.002), by stage at diagnosis (OS 2.7 years in stage I vs 0.6 years in stage IV, P < 0.001), resection status and response to systemic chemotherapy. In a multivariate model, ID protein expression did not correlate with clinical prognosis. Nevertheless, there was a trend of shorter OS in patients with loss of cytoplasmic ID4 protein expression (P = 0.076)., Conclusion: ID protein expression is frequently deregulated in BTC but does not influence clinical prognosis. Their usefulness as prognostic biomarkers in BTC is very limited.

Published
2013
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