The article is devoted to the study of intercultural competence (ICC) as a psychological phenomenon including the analysis of its models, factors, and profiles. The results of an empirical study in two major multinational Russian universities (388 students, of which 254 young women and 134 young men) are presented. The aim of the study was to identify the typological profiles of the ICC and their characteristics in relation to personality traits. ICC was studied based on the “Dynamic model of intercultural sensitivity” by M. Bennet. The author’s modification of the “Scale of intercultural sensitivity” by O.E. Khuhlaev and M.Y. Chibisova in the adaptation of Y.A. Lopashenko was used for the ICC diagnostics. Personality traits were considered in the framework of the Five-Factor Model (P. Costa and R. McCrae) and were measured by a short form of the “Five-Factor Questionnaire” in Russian adaptation by M.V. Bodunov and S.D. Biryukov. We identified four ICC profiles of students provisionally called “ethnocentrists”, “negativists”, “undecided (ambivalent)”, and “ethnorelativists”. It is shown that the profiles differ not only in the correlation between the severity of parameters of the ICC, but also in personality traits. The results can be used for the design of ICC development and formation programs, based on the identified psychological specifics of ICC profiles.