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31 results on '"Guler M.O."'

8. Extracellular matrix mimetic peptide scaffolds for neural stem cell culture and differentiation

Author

Mammadov, B., Guler, M.O., and Tekinay, A.B.

Subjects
Neural stem cells, Scaffolds, cell culture, quantitative analysis, extracellular matrix, article, Peptide nanofibers, Hydrogels, Self-assembly, peptide, molecular scaffold, amino acid sequence, Western blotting, reverse transcription polymerase chain reaction, cell differentiation, neural stem cell, cell proliferation, immunocytochemistry, priority journal, cell function, controlled study, nanofiber, cell viability, cell structure
Abstract

Self-assembled peptide nanofibers form three-dimensional networks that are quite similar to fibrous extracellular matrix (ECM) in their physical structure. By incorporating short peptide sequences derived from ECM proteins, these nanofibers provide bioactive platforms for cell culture studies. This protocol provides information about preparation and characterization of self-assembled peptide nanofiber scaffolds, culturing of neural stem cells (NSCs) on these scaffolds, and analysis of cell behavior. As cell behavior analyses, viability and proliferation of NSCs as well as investigation of differentiation by immunocytochemistry, qRT-PCR, western blot, and morphological analysis on ECM mimetic peptide nanofiber scaffolds are described. © 2014 Springer Science+Business Media New York.

Published
2014

14. Self-assembled peptidic nanostructures

Author

Toksöz S. and Guler M.O.

Subjects
collagen, phenylalanine, chirality, amphophile, Research groups, Dental prostheses, calcium phosphate, bone regeneration, Computer viruses, Molecular self assembly, alpha helix, nanoribbon, drug delivery system, Amines, Neural tissue engineering, Self-assembly supramolecular chemistry, hydroxyapatite, Self-assembly, Nanostructured materials, Self assembly, Materials development, nanorod, tooth implantation, Macromolecules, tissue engineering, Nano-materials, Useful properties, Biodegradation, Biocompatibility, nanomaterial, Nano scale, alanine, leucine, scanning electron microscopy, Cell scaffold, Functional materials, beta sheet, Natural materials, review, protein assembly, biosensor, Self assembled material, molecular scaffold, nervous tissue, peptide derivative, Gene Delivery, biodegradability, Self-assembled, transmission electron microscopy, virus identification, nanofiber, protein motif, Gene transfer, Nanomaterials, hydrophobicity, arginylglycylaspartic acid, Dental implants, Amphiphiles, Nanostructures, nanosphere, Fluorine containing polymers, Biosensors, Customizable, Antibacterial agent, nanotube, hydrogel, hydrophilicity, microbiological examination, Peptides, Supramolecular chemistry, Materials properties, glycine
Abstract

Understanding the mechanisms of molecular self-assembly processes in natural materials is an important step to developing new functional materials with useful properties. Recently, various self-assembled materials have gained attention because of their interesting properties in nanoscale. Nanostructures composed of peptides are especially of interest in materials development because of their many advantageous properties such as biodegradability, biocompatibility and customizable bioactivity. Self-assembled peptidic nanostructures have been studied by many research groups and found use as three-dimensional cell scaffolds for bone regeneration, dental implants, neural tissue engineering, biosensors for detection of viruses and other pathogens, antibacterial agents and in drug, protein and gene delivery. © 2009 Elsevier Ltd. All rights reserved.

Published
2009

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