1. Design of a System for Analyzing Cell Mechanics
- Author
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Abdioglu, Hasan Berkay, Isik, Yagmur, Sevgi, Merve, Kirabali, Ufuk Gorkem, Mert, Yunus Emre, Guldogan, Gulnihal, Serdarli, Selin, Gulen, Tarik Taha, and Uvet, Huseyin
- Subjects
Physics - Biological Physics - Abstract
Accurately measuring cell stiffness is challenging due to the invasiveness of traditional methods like atomic force microscopy (AFM) and optical stretching. We introduce a non-invasive off-axis system using holographic imaging and acoustic stimulation. This system features an off-axis Mach-Zehnder interferometer and bulk acoustic waves to capture cell mechanics. It employs high-resolution components to create detailed interferograms and allows continuous imaging of cell deformation. Unlike conventional techniques, our method provides high-throughput, label-free measurements while preserving cell integrity. Polyacrylamide beads are tested for high precision, highlighting the potential of the system in early cancer detection, disease monitoring, and mechanobiological research.
- Published
- 2024