1. Plasma D-dimer as a potential predictor of progression in IgA nephropathy: a cohort study
- Author
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Guizhen Yu, Yan Jiang, Zishu Xu, Jun Cheng, Heng Li, Xiayu Li, and Jianghua Chen
- Subjects
D-dimer ,Coagulation disorders ,IgA nephropathy ,risk factor ,kidney disease progression ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Introduction Coagulation disorders play a key role in chronic kidney disease, and the formation or elevation of plasma D-dimer levels reflects activation of the coagulation system. However, its relationship with the severity and progression of kidney disease in IgA nephropathy (IgAN) remains unclear.Methods We assessed 1818 patients with IgAN diagnosed between 2002 and 2019 at the First Affiliated Hospital, Zhejiang University School of Medicine. Plasma D-dimer levels were measured at the time of the renal biopsy. The association between plasma D-dimer levels and kidney disease progression events, defined as a 50% decline in eGFR and end-stage kidney disease (ESKD), was tested using restricted cubic splines and Cox proportional hazard models.Results The median plasma D-dimer level was 220 (170–388.5) µg/L FEU, which was significantly higher than healthy controls 170 (170–202) µg/L FEU. Plasma D-dimer levels were positively correlated with proteinuria (r = 0.211, p more...
- Published
- 2023
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