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Floriane Bethenod,1 Omar Ellouze,1 Vivien Berthoud,1 Anis Missaoui,1 Amélie Cransac,2 Serge Aho,3 Olivier Bouchot,4 Claude Girard,1 Pierre Grégoire Guinot,1 Belaid Bouhemad1 1Service d’Anesthésie Réanimation, Unité d’Anesthésie Réanimation Cardio Vasculaire, Centre Hospitalier Universitaire de Dijon, Dijon, France; 2Pharmacie Centrale, Centre Hospitalier Universitaire de Dijon, Dijon, France; 3Service d’Epidémiologie et d’Hygiène Hospitalières, Centre Hospitalier Universitaire de Dijon, Dijon, France; 4Service De Chirurgie Cardiaque, Vasculaire Et Thoracique, Centre Hospitalier Universitaire De Dijon, Dijon, FranceCorrespondence: Omar EllouzeService d’Anesthésie Réanimation, Unité d’Anesthésie Réanimation Cardio Vasculaire, Centre Hospitalier Universitaire de Dijon, BP 77908, Dijon Cedex 21709, FranceTel +33 69 508 5389Email mohamedomar.ellouze@chu-dijon.frBackground: Medial sternotomy is commonly used in cardiac surgery, although it results in intense post-operative pain. The placement of a sternal wound catheter for the administration of local anesthetic represents an effective technique. An initial bolus of tramadol in the sternal wound catheter could potentiate the effect of the local anesthetic and decrease both the post-operative pain and the morphine consumption.Patients and methods: We conducted a prospective, randomized, double-blind study at the University Hospital Center, Dijon, France. Patients requiring scheduled or non-extreme emergency surgery for valve disease, aorta disease, atrial myxoma, or coronary artery bypass graft via sternotomy were included. A sternal wound catheter was inserted at the end of the surgery. The patients were randomized to receive either a 2 mg/kg bolus of tramadol (n=80) or a placebo (n=80) in th