75 results on '"Guimarães JB"'
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2. A protocol for scoping reviews on the role of whole-body and dedicated body-part magnetic resonance imaging for assessment of adult and juvenile idiopathic inflammatory myopathies.
- Author
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Essouma M, de Araujo DB, Day J, Conticini E, Riopel MA, Elias AM, Paula VT, Omori CH, Guimarães JB, Gibson D, Saad-Magalhaes C, Appenzeller S, Schiffenbauer A, Machado PM, Feldman BM, Paik JJ, Christopher-Stine L, Rider LG, Reed A, van der Kooi AJ, Marrani E, Naddaf E, Kirkhus E, Sanner H, Bauer-Ventura I, Lilleker JB, Gupta L, Lucchini M, Dimachkie MM, Tolend M, Arabi TMA, Moghadam-Kia S, O'Hanlon S, Phaneuf S, Shinjo SK, and Doria AS
- Subjects
- Humans, Child, Adult, Whole Body Imaging methods, Research Design, Magnetic Resonance Imaging methods, Myositis diagnostic imaging, Muscle, Skeletal diagnostic imaging
- Abstract
Currently, standardized magnetic resonance imaging (MRI) scoring systems and protocols for assessment of idiopathic inflammatory myopathies (IIMs) in children and adults are lacking. Therefore, we will perform a scoping review of the literature to collate and evaluate the existing semi-quantitative and quantitative MRI scoring systems and protocols for the assessment and monitoring of skeletal muscle involvement in patients with IIMs. The aim is to compile evidence-based information that will facilitate the future development of a universal standardized MRI scoring system for both research and clinical applications in IIM. A systematic search of electronic databases (PubMed, EMBASE, and Cochrane) will be undertaken to identify relevant articles published between January 2000 and October 2023. Data will be synthesized narratively. This scoping review seeks to comprehensively summarize and evaluate the evidence on the scanning protocols and scoring systems used in the assessment of diagnosis, disease activity, and damage using skeletal muscle MRI in IIMs. The results will allow the development of consensus recommendations for clinical practice and enable the standardization of research methods for the MRI assessment of skeletal muscle changes in patients with IIMs., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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- 2024
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3. MRI of Pediatric Foot and Ankle Conditions.
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Carneiro BC, Ormond Filho AG, and Guimarães JB
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- Humans, Child, Foot diagnostic imaging, Foot Diseases diagnostic imaging, Ankle diagnostic imaging, Magnetic Resonance Imaging
- Abstract
The increase in competitive sports practice among children and lack of ionizing radiation have resulted in a higher demand for MRI examinations. MRI of the children skeleton has some particularities that can lead orthopedists, pediatricians, and radiologists to diagnostic errors. The foot and ankle have several bones with abundant radiolucent and high signal intensity cartilage in several ossification centers, apophysis and physis, that can make this interpretation even harder. The present revision aims to show, how to differentiate between normal developmental findings and anatomic variants from pathologic conditions, whether mechanical, inflammatory, infectious, or neoplastic., (Copyright © 2024 Elsevier Inc. All rights reserved.)
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- 2024
- Full Text
- View/download PDF
4. Authors' response to the Letter to the Editor.
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da Silva LNM, Filho AGO, and Guimarães JB
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- Humans
- Published
- 2024
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5. Musculoskeletal manifestations of COVID-19.
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da Silva LNM, Filho AGO, and Guimarães JB
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- Humans, COVID-19 complications, COVID-19 diagnostic imaging, Musculoskeletal Diseases diagnostic imaging, Musculoskeletal Diseases etiology, SARS-CoV-2
- Abstract
During the COVID-19 pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected millions of people worldwide, with acute respiratory distress syndrome (ARDS) being the most common severe condition of pulmonary involvement. Despite its involvement in the lungs, SARS-CoV-2 causes multiple extrapulmonary manifestations, including manifestations in the musculoskeletal system. Several cases involving bone, joint, muscle, neurovascular and soft tissues were reported shortly after pandemic onset. Even after the acute infection has resolved, many patients experience persistent symptoms and a decrease in quality of life, a condition known as post-COVID syndrome or long COVID. COVID-19 vaccines have been widely available since December 2020, preventing millions of deaths during the pandemic. However, adverse reactions, including those involving the musculoskeletal system, have been reported in the literature. Therefore, the primary goal of this article is to review the main imaging findings of SARS-CoV-2 involvement in the musculoskeletal system, including acute, subacute, chronic and postvaccination manifestations., (© 2023. The Author(s), under exclusive licence to International Skeletal Society (ISS).)
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- 2024
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6. Assessing the Analgesic Efficacy of Lumbosacral Epidural Morphine in Cats Undergoing Ovariohysterectomy: A Comparative Study of Two Doses.
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Martins LCT, Guimarães JB, Ferraz HT, de Oliveira FA, Gomes LS, Chafes CJC, Santos TCC, Ogliari K, de Moraes RS, Ribeiro D, Ramos DGS, Rocha TASS, and Regalin D
- Abstract
Opioids are administered epidurally (PV) to provide trans- and postoperative analgesia. Twenty healthy female cats aged between 6 and 24 months and weighing between 2 and 3.7 kg, undergoing elective ovariohysterectomy (OVH), were induced with propofol (8 mg/kg), followed by continuous infusion (0.1-0.4 mg/kg/min). Three groups were defined: CG (0.1 mL/kg of iodinated contrast, n = 6), G0.1 (0.1 mg/kg of morphine, n = 7), and G0.2 (0.2 mg/kg of morphine, n = 7) per VP. All received 0.1 mL/kg of iodinated contrast per VP and injection water to obtain a total of 0.3 mL/kg. Heart rate (HR), systolic blood pressure (SBP), temperature, expired CO
2 , oxygen saturation, and number of rescue analgesics were monitored. Postoperatively, a multidimensional scale was used to assess acute pain in cats for 12 h. The mean HR and SBP in the CG were higher at the time of maximum noxious stimulation and required fentanyl in all groups. Postoperatively, 83%, 28%, and 7% of the animals in CG, G0.1, and G0.2, respectively, received rescue analgesia. In cats undergoing OVH, epidural morphine at doses of 0.1 and 0.2 mg/kg did not prevent the need for intraoperative rescue analgesia but reduced the postoperative analgesic needed.- Published
- 2024
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7. Imaging spectrum of atraumatic muscle disorders: a radiologist's guide.
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Gonçalves DVC, da Silva LNM, Guimarães JB, da Cruz IAN, and Filho AGO
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- Humans, Diagnosis, Differential, Radiology, Muscular Diseases diagnostic imaging, Muscle, Skeletal diagnostic imaging
- Abstract
Atraumatic muscle disorders comprise a very wide range of skeletal muscle diseases, including metabolic, inflammatory, autoimmune, infectious, ischemic, and neoplastic involvement of the muscles. Therefore, one must take clinical and laboratory data into consideration to elucidate the differential diagnoses, as well as the distribution of the muscle compromise along the body-whether isolated or distributed along the body in a symmetric or asymmetrical fashion. Assessment of muscular disorders often requires imaging investigation before image-guided biopsy or more invasive procedures; therefore, radiologists should understand the advantages and limitations of imaging methods for proper lesion evaluation and be aware of the imaging features of such disorders, thus contributing to proper decision-making and good patient outcomes. In this review, we propose a systematic approach for the assessment of muscle disorders based on their main imaging presentation, dividing them into patterns that can be easily recognized., (© 2024. The Author(s), under exclusive licence to International Skeletal Society (ISS).)
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- 2024
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8. Measurement of tibial slope using biplanar stereoradiography (EOS®).
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Narahashi É, Guimarães JB, Filho AGO, Nico MAC, and Silva FD
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- Humans, Retrospective Studies, Reproducibility of Results, Radiography, Knee Joint diagnostic imaging, Tibia diagnostic imaging
- Abstract
Objectives: Posterior tibial slope (PTS) is an important anatomic parameter of the knee related to anteroposterior instability. Biplanar stereoradiography allows for simultaneous low-dose acquisition of anteroposterior and lateral views with 3D capability, enabling separate lateral and medial plateau analyses. We aimed to evaluate the possibility and compare the reproducibility of measuring medial and lateral PTS on EOS® images with two different patient positionings and compare it with CT of the knees as the gold standard., Methods: This is a retrospective study including volunteers who underwent lower limb stereoradiography and knee CT from 01/08/2016 to 07/31/2019. Sixty legs from 30 patients were studied. PTS were measured using stereoradiography and CT by two radiologists. Intraclass correlation was used to calculate intrarater and interrater reproducibilities. Pearson's correlation coefficients were used to calculate the correlation between stereoradiography and CT. We also compared the reproducibility of the stereoradiography of volunteers with 2 different positionings., Results: The mean stereoradiography PTS values for right and left knees were as follows: lateral, 12.2° (SD: 4.1) and 10.1° (SD: 3.5); medial,12.2° (SD: 4.4) and 11.6° (SD: 3.9). CT PTS mean values for right and left knee are as follows: lateral, 10.3° (SD:2.5) and 10.6° (SD: 2.8); medial: 8.7° (SD: 3.7) and 10.4° (SD: 3.5). Agreement between CT and EOS for angles between lateral and medial PTS was good (right, 0.874; left, 0.871). Regarding patient positioning on stereoradiography, interrater and intrarater reproducibilities were greater for patients with nonparallel feet (0.738-0.883 and 0.870-0.975)., Conclusions: Stereoradiography allows for appropriate delineation of tibial plateaus, especially in patients with nonparallel feet, for the purpose of measuring PTS. The main advantage is lower radiation doses compared to radiography and CT., (© 2023. The Author(s), under exclusive licence to International Skeletal Society (ISS).)
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- 2024
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9. The Role of Whole-Body MRI in Pediatric Musculoskeletal Oncology: Current Concepts and Clinical Applications.
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Guimarães JB, da Cruz IAN, Ahlawat S, Ormond Filho AG, Nico MAC, Lederman HM, and Fayad LM
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- Humans, Child, Bone Neoplasms diagnostic imaging, Child, Preschool, Whole Body Imaging methods, Magnetic Resonance Imaging methods
- Abstract
Whole-body magnetic resonance imaging (WB-MRI) has gained importance in the field of musculoskeletal oncology over the last decades, consisting in a one-stop imaging method that allows a wide coverage assessment of both bone and soft tissue involvement. WB-MRI is valuable for diagnosis, staging, and follow-up in many oncologic diseases and is especially advantageous for the pediatric population since it avoids redundant examinations and exposure to ionizing radiation in patients who often undergo long-term surveillance. Its clinical application has been studied in many pediatric neoplasms, such as cancer predisposition syndromes, Langerhans cell histiocytosis, lymphoma, sarcomas, and neuroblastoma. The addition of diffusion-weighted sequences allows functional evaluation of neoplastic lesions, which is helpful in the assessment of viable tumor and response to treatment after neoadjuvant or adjuvant therapy. WB-MRI is an excellent alternative to fluorodeoxyglucose-positron emission tomography/computed tomography in oncologic children, with comparable accuracy and the convenience of being radiation-free, fast to perform, and available at a similar cost. The development of new techniques and protocols makes WB-MRI increasingly faster, safer, and more accessible, and it is important for referring physicians and radiologists to recognize the role of this imaging method in pediatric oncology. LEVEL OF EVIDENCE: 4 TECHNICAL EFFICACY STAGE: 2., (© 2021 International Society for Magnetic Resonance in Medicine.)
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- 2024
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10. Whole-body muscle magnetic resonance imaging in inflammatory myopathy with mitochondrial pathology.
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Cavalcante WCP, da Silva AMS, Mendonça RH, Moreno CAM, Proença BMS, Guimarães JB, Ormond Filho AG, and Zanoteli E
- Abstract
Introduction: Inflammatory myopathy with mitochondrial pathology (IM-Mito) is a rare condition described in a few case series, and it is not clear whether it is a specific disease or a variant of Inclusion Body Myositis (IBM). Radiological data of IM-Mito patients has only been evaluated in one study., Aim: To analyze whole-body muscle magnetic resonance imaging (MRI) features in patients with IM-Mito compared with individuals with IBM., Methods: Fourteen IM-Mito and ten IBM patients were included. IM-Mito was defined by endomysial inflammatory infiltrate, presence of at least 1% of Cytochrome C Oxidase negative fibers, and absence of rimmed vacuoles in muscle biopsy; and IBM was defined by the presence of dystrophic muscular abnormalities, endomysial inflammatory infiltrate, and rimmed vacuoles. Patients underwent clinical evaluation and whole-body muscle MRI to determine the presence of edema, and fatty infiltration in various muscles., Results: Muscle imaging abnormalities were asymmetric in most patients with IM-Mito and IBM. Muscles with the highest average degree of fatty infiltration in both conditions were the quadriceps and medial gastrocnemius. Most patients with IM-Mito and IBM showed imaging patterns of rectus femoris relatively spared compared to other quadriceps muscles. The flexor digitorum profundus was the most affected muscle of the upper limbs in both IBM and IM-Mito., Discussion: Although the results suggest some similarities in muscle imaging features between IM-Mito and IBM, there remains uncertainty whether these two conditions are part of the same clinical spectrum., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Cavalcante, Silva, Mendonça, Moreno, Proença, Guimarães, Ormond Filho and Zanoteli.)
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- 2024
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11. Inulin prebiotic ameliorates type 1 diabetes dictating regulatory T cell homing via CCR4 to pancreatic islets and butyrogenic gut microbiota in murine model.
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Guimarães JB, Rodrigues VF, Pereira ÍS, Manso GMDC, Elias-Oliveira J, Leite JA, Waldetario MCGM, de Oliveira S, Gomes ABDSP, Faria AMC, Ramos SG, Bonato VLD, Silva JS, Vinolo MAR, Sampaio UM, Clerici MTPS, and Carlos D
- Subjects
- Mice, Animals, Inulin pharmacology, Prebiotics, Disease Models, Animal, T-Lymphocytes, Regulatory, Butyrates pharmacology, Forkhead Transcription Factors, Diabetes Mellitus, Type 1, Gastrointestinal Microbiome, Islets of Langerhans
- Abstract
Gut dysbiosis is linked to type 1 diabetes mellitus (T1D). Inulin (INU), a prebiotic, modulates the gut microbiota, promoting beneficial bacteria that produce essential short-chain fatty acids for immune regulation. However, how INU affects T1D remains uncertain. Using a streptozotocin-induced (STZ) mouse model, we studied INU's protective effects. Remarkably, STZ + INU mice resisted T1D, with none developing the disease. They had lower blood glucose, reduced pancreatic inflammation, and normalized serum insulin compared with STZ + SD mice. STZ + INU mice also had enhanced mucus production, abundant Bifidobacterium, Clostridium cluster IV, Akkermansia muciniphila, and increased fecal butyrate. In cecal lymph nodes, we observed fewer CD4+Foxp3+ regulatory T cells expressing CCR4 and more Foxp3+CCR4+ cells in pancreatic islets, with higher CCL17 expression. This phenotype was absent in CCR4-deficient mice on INU. INU supplementation effectively protects against experimental T1D by recruiting CCR4+ regulatory T cells via CCL17 into the pancreas and altering the butyrate-producing microbiota., Competing Interests: Conflict of interest statement. None declared., (© The Author(s) 2023. Published by Oxford University Press on behalf of Society for Leukocyte Biology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
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- 2024
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12. The Dose-Dependent Effect of Curcumin Supplementation on Inflammatory Response and Gut Microbiota Profile in High-Fat Fed C57BL/6 Mice.
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Bertoncini-Silva C, Fassini PG, Carlos D, de Paula NA, Ramalho LNZ, Rodrigues Giuliani M, Pereira ÍS, Guimarães JB, and Suen VMM
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- Male, Mice, Animals, Interleukin-10 genetics, Mice, Inbred C57BL, Obesity drug therapy, Obesity etiology, Obesity metabolism, Body Weight, Diet, High-Fat adverse effects, Dietary Supplements, Gastrointestinal Microbiome, Curcumin pharmacology
- Abstract
Scope: The prevalence of obesity has increased, with excessive consumption of high-fat foods being one of the primary causes. Curcumin, a polyphenol extracted from Curcuma longa L., exhibits anti-inflammatory activity. The study aims to investigate the effects of curcumin supplementation in different doses on the biochemical profile, inflammatory response, and gut microbiota profile in mice that are fed with high-fat diet (HFD)., Methods and Results: C57BL/6 male mice are fed a standard diet, or a HFD with or without different doses of curcumin (50, 250, and 500 mg kg
-1 of body weight). Throughout the experimental period, food intake and body weight are assessed weekly. At euthanasia, blood, stool, and tissue samples are collected for biochemical, histological, and molecular analyses. Curcumin increases the IL-10 protein expression in the white adipose tissue. In the liver, there is a reduction in tumor necrosis factor alpha (TNF-α) and an increase in IL-10 gene expression. Also, curcumin promotes the growth of butyrogenic bacteria, such as Clostridium clusters IV and XIVa., Conclusions: The findings suggest that curcumin has the potential to improve the inflammatory response and modulate healthy gut microbiota. Further studies are needed to clarify the role of curcumin as a preventive and effective strategy for obesity., (© 2023 Wiley-VCH GmbH.)- Published
- 2023
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13. Could ultrasound and muscle elastography be associated with clinical assessment, laboratory and nailfold capillaroscopy in juvenile dermatomyositis patients?
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de Andrade RLF, Mendonça JA, Piotto DP, Guimarães JB, and Terreri MT
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- Child, Humans, Child, Preschool, Adolescent, Young Adult, Adult, Microscopic Angioscopy, Cross-Sectional Studies, Muscle, Skeletal diagnostic imaging, Dermatomyositis diagnosis, Elasticity Imaging Techniques
- Abstract
Background: Juvenile Dermatomyositis (JDM) is the most common idiopathic inflammatory myopathy in children. Imaging exams are useful for muscle assessment, with ultrasonography (US) being a promising tool in detecting disease activity and tissue damage. There are few studies about muscle elastography., Objectives: Our aim was to associate clinical, laboratory, and nailfold capillaroscopy (NC) assessments with US in JDM patients; and to compare the findings of US and Strain Elastography (SE) from patients and healthy controls., Methods: An analytic cross-sectional study was performed with JDM patients and healthy controls. Patients underwent clinical exam to access muscle strength and completed questionnaires about global assessment of the disease and functional capacity. Patients were submitted to NC and measurement of muscle enzymes. All subjects underwent US assessment, using gray scale, Power Doppler (PD), and SE., Results: Twenty-two JDM patients and fourteen controls, aged between 5 and 21 years, matched for age and sex were assessed. In qualitative and semi-quantitative gray scale, we observed a higher frequency of alterations in patients (p < 0.001), while in PD, there was a higher frequency of positivity in patients' deltoids and anterior tibialis (p < 0.001). Active disease was associated with an important change in the semi-quantitative gray scale in deltoids (p = 0.007), biceps brachii (p = 0.001) and quadriceps femoris (p = 0.005). The SE demonstrated a high negative predictive value of 87.2., Conclusion: US was able, through gray scale, to differentiate JDM patients from controls, while PD achieved such differentiation only for deltoids and anterior tibialis. The semi-quantitative gray scale showed disease activity in proximal muscles. SE was not able to differentiate patients from controls., (© 2023. Sociedade Brasileira de Reumatologia.)
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- 2023
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14. Administration of an excessive dosage of covid-19 pfizer vaccine in an infant: Case report of clinical and immune responses.
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E Silva JM, Guimarães JB, Abu Jamra SR, Mirante BS, Capato CF, de Melo Jorge DM, and da Fonseca BAL
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Introduction/case Report: We describe the case of a 6-month-old female infant who received the equivalent of 6 adult doses of the COVID-19 Pfizer vaccine due to an immunization error. The patient underwent clinical and laboratory evaluations from the time of vaccination error (January 2022) until November 2022. In the first three days after immunization, she presented with low-grade fever (38 °C) and mild pain and induration at the injection site. She showed no other symptoms afterwards. Laboratory tests were within normal limits for age, except for an elevated D-dimer (3.71 ug/mL; normal: up to 0.5 ug/mL) and as the echocardiogram and electrocardiogram were within normal limits as well, no interventions were instituted at that moment. On the tenth day, immune response evaluation showed a strong expression of cytokines related to the Th2 profile and a well-controlled inflammatory state. Forty-three days after the vaccine administration inflammation status remained, with a predominance of cellular immune response, IFN-γ expression increased compared to the previous evaluation, and a robust antiviral state was in place. After 90 days, immune response evaluation showed a significant reduction in the inflammatory state, still with a predominance of the cellular immune response. Clinically, the patient remained well, with no other noteworthy intercurrences, until the last appointment in November 2022. This child has had no evidence of a severe adverse effect associated to the vaccine overdose., Conclusion: The close follow-up of this case of vaccination error demonstrated that the COVID-19 Pfizer was safe and immunogenic in this individual, noting careful monitoring and followup of these vaccine administration errors is crucial., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2023 The Authors. Published by Elsevier Ltd.)
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- 2023
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15. MRI of Pediatric Foot and Ankle Conditions.
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Carneiro BC, Ormond Filho AG, and Guimarães JB
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- Humans, Child, Magnetic Resonance Imaging methods, Ankle diagnostic imaging, Ankle Joint diagnostic imaging, Ankle Joint pathology
- Abstract
The increase in competitive sports practice among children and lack of ionizing radiation have resulted in a higher demand for MRI examinations. MRI of the children skeleton has some particularities that can lead orthopedists, pediatricians, and radiologists to diagnostic errors. The foot and ankle have several bones with abundant radiolucent and high signal intensity cartilage in several ossification centers, apophysis and physis, that can make this interpretation even harder. The present revision aims to show, how to differentiate between normal developmental findings and anatomic variants from pathologic conditions, whether mechanical, inflammatory, infectious, or neoplastic., (Copyright © 2023 Elsevier Inc. All rights reserved.)
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- 2023
- Full Text
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16. Prevalence of phalangeal bone marrow edema on MRI before and during the COVID-19 pandemic and correlation with chilblain skin lesions.
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da Silva LNM, Guimarães JB, Link TM, da Cruz IAN, Silva FD, Nico MAC, and Filho AGO
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- Male, Middle Aged, Humans, Female, Adult, Pandemics, Bone Marrow diagnostic imaging, Bone Marrow pathology, Retrospective Studies, Prevalence, Magnetic Resonance Imaging methods, Edema pathology, COVID-19 epidemiology, Chilblains diagnostic imaging, Chilblains epidemiology, Skin Diseases, Bone Marrow Diseases epidemiology
- Abstract
Objective: The purpose of this study is to establish the prevalence bone marrow edema of the phalanges of the feet and hands before and during the COVID-19 pandemic on MRI studies and correlate with clinically chilblain skin lesions and epidemiological data., Methods: This observational retrospective study. In patients with confirmed bone marrow edema of the phalanges, epidemiological data and clinical findings were collected, including the history of current or remote COVID-19 infection and vaccination status. The two-proportion test was used to compare the frequency of bone marrow edema in the phalanges before and during the pandemic, and the comparison between the categories variables was performed using the one-proportion test., Results: Of the total of 7215 patients, only 20 presented isolated bone marrow edema of the digits in MRI studies; 2 (0.05%) were found two years before the pandemic's beginning, and 18 (0.64%) after the pandemic's onset, demonstrating an increase of 13-fold in this period. 16 were women with a mean age of 40.3 years and 4 were men with a mean age of 53.5 years. The most frequently reported clinical symptoms by the patients were pain (85.0%), and erythema of the skin (45.0%). Of the 18 patients found after the pandemic's onset, only 27.8% had COVID-19 infections confirmed by RT-PCR before the imaging study, and all cases were mild., Conclusion: This study demonstrated a significant increase in the prevalence of bone marrow edema of the phalanges after the onset of the COVID-19 pandemic, particularly in middle-aged and younger women., (© 2023. The Author(s), under exclusive licence to International Skeletal Society (ISS).)
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- 2023
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17. Whole-Body MRI in Musculoskeletal Oncology: A Comprehensive Review with Recommendations.
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Cruz IAN, Fayad LM, Ahlawat S, Lederman HM, Nico MAC, Ormond Filho AG, and Guimarães JB
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- Humans, Child, Magnetic Resonance Imaging methods, Diffusion Magnetic Resonance Imaging methods, Positron-Emission Tomography methods, Positron Emission Tomography Computed Tomography methods, Neoplasms diagnostic imaging
- Abstract
Whole-body (WB) MRI has emerged as an attractive method for oncologic evaluation, potentially replacing conventional imaging modalities and providing a one-step wide-coverage assessment of both the skeleton and soft tissues. In addition to providing anatomic information, WB MRI may also yield a functional analysis with the inclusion of diffusion-weighted imaging (DWI). DWI translates microstructural changes, resulting in an excellent alternative to fluorodeoxyglucose PET/CT. WB MRI (with DWI) offers comparable accuracy to PET/CT and has the advantage of avoiding ionizing radiation. Technological advances and the development of faster protocols have prompted greater accessibility of WB MRI, with growing applications in routine practice for the diagnosis, staging, and follow-up of cancer. This review discusses the technical considerations, clinical applications, and accuracy of WB MRI in musculoskeletal oncology. Keywords: Pediatrics, MR Imaging, Skeletal-Axial, Skeletal-Appendicular, Soft Tissues/Skin, Bone Marrow, Extremities, Oncology, Musculoskeletal Imaging © RSNA, 2023.
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- 2023
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18. Tendon injections - upper extremity.
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Silva FD, Zorzenoni F, da Silva LNM, Dos Reis Teixeira Neto A, Gonzalez MT, Filho AGO, and Guimarães JB
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- Humans, Tendons diagnostic imaging, Adrenal Cortex Hormones, Upper Extremity, Tenosynovitis diagnostic imaging, Tenosynovitis drug therapy, Tendinopathy diagnostic imaging, Tendinopathy drug therapy
- Abstract
Imaging-guided tendon procedures aim to reduce pain and increase function by controlling inflammation and stimulating healing. Ultrasound is the preferable guiding modality due to its high resolution and real-time demonstration of the tendinous anatomy and needle positioning. The technique includes appropriate patient positioning, which varies depending on the targeted tendon, as well as sterile and proper draping. For most procedures, we prefer the "in-plane" approach, which demonstrates the entire needle as it advances through different tissue layers. Upper limb injections commonly use corticosteroids and anesthetics with different reported short- and long-term results depending on the tendon treated; better results are obtained in the treatment of tenosynovitis (sliding tendons such as trigger finger and De Quervain's tenosynovitis). Shoulder and elbow tendinopathies (anchor tendons) may also benefit from injections containing irritants or healing stimulants such as dextrose (prolotherapy) and platelet-rich plasma or by the stimulation of healing via tendon perforations (fenestration). The hyaluronic acid injection has also been used in the treatment of both tenosynovitis and tendinopathies. For tendons passing through osteofibrous tunnels, an additional release may be performed, and the techniques are discussed in this review. Therefore, this article provides practicing musculoskeletal radiologists and trainees with a comprehensive review of tendon injection musculoskeletal image-guided procedures., (© 2022. The Author(s), under exclusive licence to International Skeletal Society (ISS).)
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- 2023
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19. Genetic Diversity and Population Structure of Cowpea ( Vigna unguiculata (L.) Walp.) Landraces from Portugal and Mozambique.
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Guimarães JB, Nunes C, Pereira G, Gomes A, Nhantumbo N, Cabrita P, Matos J, Simões F, and Veloso MM
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Cowpea ( Vigna unguiculata (L.) Walp.) is currently a legume crop of minor importance in Europe but a highly relevant staple crop in Africa and the second most cultivated legume in Mozambique. In Portugal and Mozambique, cowpea's phenotypic and genetic variation has been maintained locally by farmers in some areas. We used the molecular markers SSR, SilicoDArT and SNP to analyze the genetic diversity and population structure of 97 cowpea accessions, mainly from Portugal (Southern Europe) and Mozambique (Southern Africa). As far as we know, this is the first time that the genetic variation and the relationship between cowpea landraces collected in Portugal with those originated in Mozambique is reported. Despite the shared historical past, the Portuguese landraces did not share a common genetic background with those from Mozambique, and two different gene pools were revealed. Knowledge of the genetic structure of cowpea landraces offers an opportunity for individual selection within landraces adapted to particular eco-physiological conditions and suggests the existence of a valuable gene pool for exploitation in future Portugal-PALOP (Portuguese-speaking African countries) cowpea breeding programs.
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- 2023
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20. Xenogeneic mesenchymal stem cell biocurative improves skin wounds healing in diabetic mice by increasing mast cells and the regenerative profile.
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Manso GMDC, Elias-Oliveira J, Guimarães JB, Pereira ÍS, Rodrigues VF, Burger B, Fantacini DMC, de Souza LEB, Rodrigues HG, Bonato VLD, Silva JS, Ramos SG, Tostes RC, Manfiolli AO, Caliari-Oliveira C, and Carlos D
- Abstract
Introduction: Diabetes mellitus (DM) is a chronic disease and a major cause of mortality and morbidity worldwide. The hyperglycemia caused by DM induces micro and macrovascular complications that lead, among other consequences, to chronic wounds and amputations. Cell therapy and tissue engineering constitute recent therapeutic alternatives to improve wound healing in diabetic patients. The current study aimed to analyze the effectiveness of biocuratives containing human mesenchymal stem cells (MSCs) associated with a hydrogel matrix in the wound healing process and related inflammatory cell profile in diabetic mice., Methods: Biocuratives containing MSCs were constructed by 3D bioprinting, and applied to skin wounds on the back of streptozotocin (STZ)-induced type 1 diabetic (T1D) mice. The healing process, after the application of biocuratives with or without MSCs was histologically analyzed. In parallel, genes related to growth factors, mast cells (MC), M1 and M2 macrophage profiles were evaluated by RT-PCR. Macrophages were characterized by flow cytometry, and MC by toluidine blue staining and flow cytometry., Results: Mice with T1D exhibited fewer skin MC and delayed wound healing when compared to the non-diabetic group. Treatment with the biocuratives containing MSCs accelerated wound healing and improved skin collagen deposition in diabetic mice. Increased TGF-β gene expression and M2 macrophage-related markers were also detected in skin of diabetic mice that received MSCs-containing biocuratives. Finally, MSCs upregulated IL-33 gene expression and augmented the number of MC in the skin of diabetic mice., Conclusion: These results reveal the therapeutic potential of biocuratives containing MSCs in the healing of skin wounds in diabetic mice, providing a scientific base for future treatments in diabetic patients., Competing Interests: CCO and AOM are partners is In Situ Cell Therapy and are named as inventors of a provisional patent directed at this manuscript, which is solely owned by In Situ Cell Therapy., (© 2022 The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V.)
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- 2023
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21. Clinical and Radiological Results after Endoscopic Treatment for Gluteal Tendon Injuries with a Minimum Follow-Up of 12 Months.
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Bitar AC, Guimarães JB, Marques R, de Castro Trindade CA, Filho AGO, Nico MAC, and de Amorim Cabrita HAB
- Abstract
Objectives: The study aimed to evaluate the clinical and radiological results after endoscopic repair of gluteus medius muscle injuries and proposed an anatomical classification for the different injury classes., Methods: A retrospective case series, including patients who had undergone endoscopic repair of the hip abductor tendon. The surgical procedure was standardized. Magnetic resonance imaging (MRI) studies were analyzed, and the injuries were classified into three types: nontransfixing partial-extension (nTPE) tear, transfixing partial-extension (TPE) tear, and transfixing full-extension (TFE) tear. TPE and TFE were considered high-grade tears. The postoperative outcomes were as follows: duration of walking aid requirement, duration of physical therapy, time to return to daily activities, modified Harris Hip score (mHHS) and Nonarthritic Hip Score (NAHS) functional scores, pain visual analog scale (VAS), satisfaction, claudication, Trendelenburg test, and reoperation., Results: Sixteen patients were included (94% women; mean age 65 years), with a mean follow-up of 42 months (12-131, range). Out of the cases with preoperative exams available for analysis, four cases (31%) were nTPE, three (23%) TPE, and six (46%) TFE tears. Thus, 69% of the patients had high-grade injuries. These patients had a higher degree of fat infiltration (P = 0.034), but this was not correlated with inferior postoperative clinical or radiological results. One patient required reoperation due to a recurrent injury., Conclusion: Isolated extra-articular injuries to the tendons of the gluteus medius and minimus evolved satisfactorily after endoscopic repair. Due to the small number of cases, it was not possible to observe differences in outcomes between high-and low-grade injuries., Competing Interests: None, (2023 © BY THE ARCHIVES OF BONE AND JOINT SURGERY.)
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- 2023
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22. Whole-Body MRI in Limb Girdle Muscular Dystrophy Type R1/2A: Correlation With Clinical Scores.
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Aivazoglou LU, Guimarães JB, Costa MAF, Aihara AY, Cardoso FN, Pinto WBVR, de Souza PVS, da Silva AMS, Zanoteli E, Oliveira ASB, Carvalho AAS, and Fernandes ADRC
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- Humans, Magnetic Resonance Imaging methods, Muscle, Skeletal diagnostic imaging, Muscular Diseases, Muscular Dystrophies, Limb-Girdle
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Introduction/aim: The most common limb girdle muscular dystrophy (LGMD) worldwide is LGMD type R1 (LGMDR1). The aim of this study was to correlate the MRI findings with functional scores and to describe the whole-body MRI (WBMRI) pattern in a LGMDR1 Brazilian cohort., Methods: LGMDR1 patients under follow-up in three centers were referred for the study. Clinical data were collected and a functional evaluation was performed, consisting of Gardner-Medwin and Walton (GMW) and Brooke scales. All patients underwent a WBMRI study (1.5T) with axial T1 and STIR images. Fifty-one muscles were semiquantitatively assessed regarding fatty infiltration and muscle edema., Results: The study group consisted of 18 patients. The highest fatty infiltration scores involved the serratus anterior, biceps femoris long head, adductor magnus, and lumbar erector spinae. There was a latero-medial and caudo-cranial descending gradient of involvement of the paravertebral muscles, with erector spinae being significantly more affected than the transversospinalis muscles (p < 0.05). A striped appearance that has been dubbed the "pseudocollagen sign" was present in 72% of the patients. There was a positive correlation between the MRI score and GMW (Rho:0.83) and Brooke (Rho:0.53) scores., Discussion: WBMRI in LGMDR1 allows a global patient evaluation including involvement of the paraspinal muscles, usually an underestimated feature in the clinical and imaging study of myopathies. Knowledge of the WBMRI pattern of LGMDR1 involvement can be useful in the diagnostic approach and in future studies to identify the best target muscles to serve as outcome measures in clinical trials., (© 2022 Wiley Periodicals LLC.)
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- 2022
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23. Sacroiliac joint beyond sacroiliitis-further insights and old concepts on magnetic resonance imaging.
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Carneiro BC, Rizzetto TA, Silva FD, da Cruz IAN, Guimarães JB, Ormond Filho AG, and Nico MAC
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- Edema pathology, Humans, Magnetic Resonance Imaging methods, Sacroiliac Joint diagnostic imaging, Sacroiliac Joint pathology, Bone Marrow Diseases pathology, Sacroiliitis diagnostic imaging, Sacroiliitis pathology, Spondylarthritis pathology
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The sacroiliac joint (SIJ) is an amphiarthrosis composed of a posterior syndesmosis and an anterior cartilaginous portion, with limited yet present mobility. Its main function is to transmit the load from the axial skeleton to the lower limbs and vice-versa; it is susceptible to early mechanical and degenerative changes which are much more common than inflammatory sacroiliitis. Magnetic resonance imaging (MRI) has increasingly been used to evaluate these changes, and while subchondral bone marrow edema (BME) is a common finding related to both, care must be taken when applying the ASAS research MRI definition for sacroiliitis without considering lesion BME topography, size and depth, concomitant structural damage and, of course, the clinical picture. In this review, we will discuss the anatomy and biomechanics of the SIJ, the noninflammatory causes of SIJ subchondral BME, and how these concepts combined can be used to increase our diagnostic confidence., (© 2022. The Author(s), under exclusive licence to International Skeletal Society (ISS).)
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- 2022
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24. Chronic nonbacterial osteomyelitis: the role of whole-body MRI.
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Nico MAC, Araújo FF, Guimarães JB, da Cruz IAN, Silva FD, Carneiro BC, and Filho AGO
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Background: Chronic nonbacterial osteomyelitis (CNO), also known as chronic recurrent multifocal osteomyelitis, is a noninfectious autoinflammatory disorder that occurs primarily in children and adolescents and is characterized by episodic musculoskeletal pain with a protracted course., Main Body: Traditionally, the diagnosis of CNO is made by exclusion and commonly requires bone biopsy to rule out infection and malignancy. However, bone biopsy may be avoided when imaging and clinical characteristic features are present, such as multifocal bone lesions at typical sites, no constitutional symptoms and no signs of infection in laboratory test results. Whole-body magnetic resonance imaging (WB-MRI) can assess signs of acute and chronic inflammation and enables the detection of CNO typical patterns of lesion location and distribution, thereby helping to exclude differential diagnosis. The goal of the present study paper is to review the main clinical and imaging aspects of the disease with emphasis on the role of WB-MRI in the diagnosis, assessment of disease burden and follow-up monitoring., Conclusion: Radiologists need to be familiar with the imaging features to suggest the diagnosis as the early therapy may help to avoid irreversible secondary damage of skeletal system., (© 2022. The Author(s).)
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- 2022
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25. Meniscal Root Tears: An Update Focused on Preoperative and Postoperative MRI Findings.
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Guimarães JB, Chemin RN, Araujo FF, Link TM, Silva FD, Bitar A, Nico MAC, and Filho AGO
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- Arthroscopy methods, Humans, Magnetic Resonance Imaging methods, Menisci, Tibial anatomy & histology, Menisci, Tibial diagnostic imaging, Menisci, Tibial surgery, Knee Injuries diagnostic imaging, Knee Injuries surgery, Tibial Meniscus Injuries diagnostic imaging, Tibial Meniscus Injuries surgery
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Meniscal root tears represent radial tears or avulsions of the meniscal cartilage at the tibial attachment site that profoundly affect meniscal biomechanics and kinematics. Meniscal root tears have the functional effect of a total meniscectomy and can lead to rapid degenerative change with development of early knee osteoarthritis (OA). A growing range of arthroscopic surgical techniques have been developed to repair meniscal root tears with the aim of restoring joint kinematics and contact pressures and delaying the development of OA. With increased understanding of the anatomy and biomechanics of the meniscal root, meniscal root injury repair has become the treatment of choice in knees with nonadvanced OA. This article reviews the anatomy and biomechanics of the meniscal roots, clinical and imaging diagnostic criteria of meniscal root tears, correlation between arthroscopy and MRI in the diagnosis and classification of meniscal root tears, and expected and abnormal MRI findings after meniscal root repair. Familiarity with MRI signs and classifications of meniscal root tears, as well as with root repair surgical techniques, can aid radiologists in correctly reporting preoperative and postoperative MRI findings.
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- 2022
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26. Genome-wide clonal variability in European pear "Rocha" using high-throughput sequencing.
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Serra O, de Sousa RM, Guimarães JB, Matos J, Vicente P, de Sousa ML, and Simões F
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Pears ( Pyrus ) are one of the most economically important fruits worldwide. The Pyrus genus is characterized by a high degree of genetic variability between species and interspecific hybrids, and several studies have been performed to assess this variability for both cultivated and wild accessions. These studies have mostly been limited by the resolving power of traditional molecular markers, although in the recent past the availability of reference genome sequences or SNP arrays for pear have enhanced the capability of high-resolution genomics studies. These tools can also be applied to better understand the intra-varietal (or clonal) variability in pear. Here we report the first high resolution genomics analysis of a pear clonal population using whole genome sequencing (WGS). Results showed unique signatures for the accumulation of mutations and transposable element insertions in each clone, which are likely related to their history of propagation and cultivation. The nucleotide diversity remained low in the clonal collection with the exception of few genomic windows, suggesting that balancing selection may be occurring. These windows included mainly genes related to plant fertility. Regions with higher mutational load were partially associated with transcription factors, probably reflecting the distinctive phenotypes in the collection. The annotation of variants also revealed the theoretical disruption of relevant genes in pear. Taken together, the results from this study show that pear clones accumulate mutations differently, and that those mutations can play a role on pear phenotypes, meaning that the study of pear clonal populations can be relevant in genetic studies, mainly when comparing with traditional association studies., Competing Interests: The authors declare no conflict of interest., (© The Author(s) 2022. Published by Oxford University Press on behalf of Nanjing Agricultural University.)
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- 2022
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27. O papel da estereorradiografia na avaliação das deformidades dos membros inferiores.
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Silva FD, Chemin RN, Ormond Filho AG, Guimarães JB, Zorzenoni FO, and Nico MAC
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As deformidades dos membros inferiores são uma condição comum e podem levar a alterações da marcha e afetar a função e longevidade das articulações do quadril, do joelho e da coluna. Uma abordagem diagnóstica sistemática é essencial para definir o tratamento e alcançar o resultado terapêutico desejado com a menor taxa de complicações. A radiografia panorâmica é frequentemente utilizada para caracterizar as deformidades dos membros inferiores por meio de medidas de comprimento e desvios angulares dos eixos, além de se tratar de um método de baixo custo e alta disponibilidade. No entanto, como é frequente a combinação de deformidades em dois ou três planos ortogonais dos membros, a avaliação radiográfica perde acurácia por se tratar de um método de imagem bidimensional. Nesse sentido, deformidades em valgo/varo avaliadas radiograficamente no plano coronal apresentarão variações crescentes nas medidas dependendo do grau de flexão/ recurvatum , torções ósseas anômalas ou, não menos importante, um posicionamento inadequado. A estereorradiografia biplanar de baixa dose, por meio de modelos tridimensionais, permite obter medidas mais acuradas de vários parâmetros usados na avaliação das deformidades dos membros inferiores, incluindo comprimentos, eixos e as torções tibial e femoral, antes disponíveis apenas pela tomografia computadorizada, com a vantagem de ser realizada em posição funcional com carga. Além disso, por permitir uma avaliação global da cabeça aos pés, abre uma nova perspectiva de compreender a inter-relação das deformidades dos membros com o posicionamento da bacia e com as deformidades da coluna.
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- 2022
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28. Subaxial spine trauma: radiological approach and practical implications.
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Masson de Almeida Prado R, Masson de Almeida Prado JL, Ueta RHS, Guimarães JB, and Yamada AF
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- Humans, Magnetic Resonance Imaging, Spinal Injuries classification, Spinal Injuries etiology, Tomography, X-Ray Computed, Cervical Vertebrae injuries, Spinal Injuries diagnostic imaging
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The cervical spine is part of the axial skeleton and is responsible for protecting vital structures, such as the spinal cord and the vertebral arteries and veins. Traumatic injury to the cervical spine occurs in approximately 3% of blunt trauma injuries, and approximately 80% are below the level of C2. The AO Spine society divides the spine into four segments: the upper cervical spine (C0-C2), subaxial spine (C3-C7), thoracolumbar spine, and sacral spine. Various classifications have been proposed for the subaxial segment since that of Allen and Ferguson in 1982; however, none is universally accepted, and treatment remains controversial. The complex anatomy and biomechanics of the subaxial spine and the lack of a widely accepted classification system make these injuries difficult to evaluate on imaging. The Subaxial Injury Classification System (SLIC) uses fracture morphology, the integrity of discoligamentous complex, and neurological status to score the patient and determine between operative and non-operative management; however, other factors may influence management, such as time for immobilisation, osteoporosis, surgeon's experience, and hospital circumstances. SLIC classifies fracture morphology in a crescent order of severity based on Allen and Ferguson's classification. Compression fractures are the simpler ones, while both distraction injuries and translation/rotation are severe injuries, which are always associated with some degree of discoligamentous complex (DLC) injury. This article will review the indications for imaging, the basis of the SLIC classification, the different types of fracture morphology, evaluation of the DLC, and other features important in decision making in subaxial spine trauma., (Copyright © 2021 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.)
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- 2021
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29. MR imaging of inherited myopathies: a review and proposal of imaging algorithms.
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Aivazoglou LU, Guimarães JB, Link TM, Costa MAF, Cardoso FN, de Mattos Lombardi Badia B, Farias IB, de Rezende Pinto WBV, de Souza PVS, Oliveira ASB, de Siqueira Carvalho AA, Aihara AY, and da Rocha Corrêa Fernandes A
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- Algorithms, Humans, Magnetic Resonance Imaging, Muscles, Radiologists, Muscular Diseases diagnostic imaging, Muscular Diseases genetics
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Purpose of Review: The aims of this review are to discuss the imaging modalities used to assess muscle changes in myopathies, to provide an overview of the inherited myopathies focusing on their patterns of muscle involvement in magnetic resonance imaging (MR), and to propose up-to-date imaging-based diagnostic algorithms that can help in the diagnostic workup., Conclusion: Familiarization with the most common and specific patterns of muscular involvement in inherited myopathies is very important for radiologists and neurologists, as imaging plays a significant role in diagnosis and follow-up of these patients., Key Points: • Imaging is an increasingly important tool for diagnosis and follow-up in the setting of inherited myopathies. • Knowledge of the most common imaging patterns of muscle involvement in inherited myopathies is valuable for both radiologists and neurologists. • In this review, we present imaging-based algorithms that can help in the diagnostic workup of myopathies., (© 2021. European Society of Radiology.)
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- 2021
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30. Osteochondral lesions of the talar dome: an up-to-date approach to multimodality imaging and surgical techniques.
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Guimarães JB, da Cruz IAN, Nery C, Silva FD, Ormond Filho AG, Carneiro BC, and Nico MAC
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- Ankle Joint diagnostic imaging, Ankle Joint surgery, Arthroscopy, Humans, Magnetic Resonance Imaging, Multimodal Imaging, Cartilage, Articular diagnostic imaging, Cartilage, Articular surgery, Talus diagnostic imaging, Talus surgery
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Osteochondral lesions (OCLs) of the talar dome consist of a multifactorial pathology of the articular cartilage and subchondral bone and can result in persistent ankle pain and osteoarthritis (OA). Along with a physical examination and clinical history, an imaging evaluation plays a pivotal role in the diagnosis of these lesions and is fundamental for making treatment decisions and determining prognosis by providing information regarding the size, location, and cartilage and subchondral bone statuses as well as associated lesions and degenerative changes. Multiple surgical techniques for OCLs of the talar dome have been developed in recent decades, including cartilage repair, regeneration, and replacement strategies, and radiologists should be acquainted with their specific expected and abnormal postoperative imaging findings to better monitor the results and predict poor outcomes. The present article proposes a thorough review of the ankle joint anatomy and biomechanics, physiopathology, diagnosis, and treatment of OCLs of the talar dome, highlighting the radiological approach and imaging findings in both pre- and postoperative scenarios., (© 2021. ISS.)
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- 2021
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31. Microbiome and oral squamous cell carcinoma: a possible interplay on iron metabolism and its impact on tumor microenvironment.
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Arthur RA, Dos Santos Bezerra R, Ximenez JPB, Merlin BL, de Andrade Morraye R, Neto JV, Fava NMN, Figueiredo DLA, de Biagi CAO Jr, Montibeller MJ, Guimarães JB, Alves EG, Schreiner M, da Costa TS, da Silva CFL, Malheiros JM, da Silva LHB, Ribas GT, Achallma DO, Braga CM, Andrade KFA, do Carmo Alves Martins V, Dos Santos GVN, Granatto CF, Terin UC, Sanches IH, Ramos DE, Garay-Malpartida HM, de Souza GMP, Slavov SN, and Silva WA Jr
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- Alcohol Drinking, Electronic Nicotine Delivery Systems, Ferric Compounds metabolism, Humans, Precancerous Conditions microbiology, Carcinoma, Squamous Cell microbiology, Iron metabolism, Microbiota, Mouth Neoplasms microbiology, Tumor Microenvironment
- Abstract
There is increasing evidence showing positive association between changes in oral microbiome and the occurrence of oral squamous cell carcinoma (OSCC). Alcohol- and nicotine-related products can induce microbial changes but are still unknown if these changes are related to cancerous lesion sites. In an attempt to understand how these changes can influence the OSCC development and maintenance, the aim of this study was to investigate the oral microbiome linked with OSCC as well as to identify functional signatures and associate them with healthy or precancerous and cancerous sites. Our group used data of oral microbiomes available in public repositories. The analysis included data of oral microbiomes from electronic cigarette users, alcohol consumers, and precancerous and OSCC samples. An R-based pipeline was used for taxonomic and functional prediction analysis. The Streptococcus spp. genus was the main class identified in the healthy group. Haemophilus spp. predominated in precancerous lesions. OSCC samples revealed a higher relative abundance compared with the other groups, represented by an increased proportion of Fusobacterium spp., Prevotella spp., Haemophilus spp., and Campylobacter spp. Venn diagram analysis showed 52 genera exclusive of OSCC samples. Both precancerous and OSCC samples seemed to present a specific associated functional pattern. They were menaquinone-dependent protoporphyrinogen oxidase pattern enhanced in the former and both 3',5'-cyclic-nucleotide phosphodiesterase (purine metabolism) and iron(III) transport system ATP-binding protein enhanced in the latter. We conclude that although precancerous and OSCC samples present some differences on microbial profile, both microbiomes act as "iron chelators-like" potentially contributing to tumor growth., (© 2021. Sociedade Brasileira de Microbiologia.)
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- 2021
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32. Stener-like lesions in the hand, knee and foot: a review of anatomy, mechanism of injury and imaging evaluation.
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Carneiro BC, Araújo FF, Guimarães JB, Chemin RN, Jorge RB, Filho AGO, and Nico MAC
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- Diagnostic Imaging, Humans, Knee Joint, Rupture, Metacarpophalangeal Joint diagnostic imaging, Thumb diagnostic imaging
- Abstract
A Stener lesion is a displaced tear of the ulnar collateral ligament in the metacarpophalangeal joint of the thumb in which the adductor pollicis aponeurosis is positioned between the retracted ligament and the injury site, preventing natural healing. This lesion was first described in 1962, and since then, both radiologists and orthopedists have considered it important to treat surgically. Although this lesion was originally described in the thumb, this injury mechanism can occur in other joints of the hand, knee, and foot. The purpose of this study was to review the relevant aspects of classic Stener lesions of the thumb, as well as other Stener-like lesions, including their anatomy, mechanisms of lesion formation and imaging features. The Stener-like injury pattern often necessitates surgical repair or reconstruction; thus, it is essential that radiologists recognize and report the different patterns of injury., (Copyright © 2021 Elsevier Inc. All rights reserved.)
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- 2021
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33. Histoplasmosis tenosynovitis of the forearm and wrist: imaging, surgical and pathologic findings.
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Zorzenoni FO, Link TM, de Biase Cabral de Sousa B, de Menezes Y, and Guimarães JB
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- Forearm diagnostic imaging, Humans, Male, Middle Aged, Wrist diagnostic imaging, Wrist Joint diagnostic imaging, Wrist Joint surgery, Histoplasmosis diagnostic imaging, Tenosynovitis diagnostic imaging
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Histoplasmosis is a disease endemic to several parts of the world, including South America. It progresses in a mostly asymptomatic and self-limiting manner but has the potential to cause disseminated pulmonary infection, especially in immunocompromised patients. Rare reports from the literature describe musculoskeletal manifestations related to the two varieties of the pathogen that cause histoplasmosis, namely, the capsulatum or duboissi variety. In this report, we describe the case of a previously healthy, middle-aged man, with slowly progressing pain in the right forearm, wrist, and fingers, diagnosed with a case of pathologically confirmed histoplasmosis tenosynovitis. We also describe the imaging, surgical, and histological findings and discuss the differential diagnoses for tenosynovitis, in case of atypical infections.
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- 2021
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34. Spine trauma: Radiological approach and new concepts.
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de Almeida Prado RM, de Almeida Prado JLM, Yamada AF, Correa Fernandes AR, Puertas EB, Ueta RHS, and Guimarães JB
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- Humans, Lumbar Vertebrae injuries, Radiography, Thoracic Vertebrae injuries, Spinal Fractures diagnostic imaging, Spinal Injuries diagnostic imaging
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The spine is the main stabilizer and load bearer of the axial skeleton. It is also important for the protection of neural structures, such as the spinal cord, nerve roots, and cauda equina. In the healthy skeleton, most injuries are a consequence of high-energy trauma and can lead to severe dysfunction, such as tetraplegia or paraplegia. In order to avoid such disabilities, it is important to recognize details that will guide treatment, and that will determine the necessity or not to have surgery. Familiarity with radiography, CT, and MRI in evaluating spine trauma is necessary, as, in some cases, all three methods will be useful in determining management and surgical planning. The most important factor in determining management in the thoracolumbar spine is the posterior ligamentous complex (PLC). Therefore, familiarity with its anatomy, primary and secondary signs of its injuries, is essential for radiologists in the emergency setting. Spine fractures are a very heterogeneous group of disorders. Management can be both conservative and surgical. It is important for radiologists to be aware of classifications and patterns for these injuries.
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- 2021
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35. NLRP1 acts as a negative regulator of Th17 cell programming in mice and humans with autoimmune diabetes.
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Costa FRC, Leite JA, Rassi DM, da Silva JF, Elias-Oliveira J, Guimarães JB, Foss-Freitas MC, Câmara NOS, Pontillo A, Tostes RC, Silva JS, and Carlos D
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- Animals, Humans, Male, Mice, Mice, Inbred NOD, Rats, Autoimmune Diseases genetics, Diabetes Mellitus, Experimental genetics, Diabetes Mellitus, Type 1 genetics, NLR Proteins metabolism, Th17 Cells immunology
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Type 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of pancreatic β cells. We show here that the protein NOD-like receptor family pyrin domain containing 1 (NLRP1) has a key role in the pathogenesis of mouse and human T1D. More specifically, downregulation of NLRP1 expression occurs during T helper 17 (Th17) differentiation, alongside greater expression of several molecules related to Th17 cell differentiation in a signal transducers and activators of transcription 3 (STAT3)-dependent pathway. These changes lead to a consequent increase in interleukin 17 (IL-17) production within the pancreas and higher incidence of diabetes in streptozotocin (STZ)-injected mice. Finally, in patients with T1D and a SNP (rs12150220) in NLRP1, there is a robust decrease in IL-17 levels in serum and in memory Th17 cells from peripheral blood mononuclear cells. Our results demonstrate that NLRP1 acts as a negative regulator of the Th17 cell polarization program, making it an interesting target for intervention during the early stages of T1D., Competing Interests: Declaration of interests The authors declare no competing financial interests., (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
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- 2021
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36. Knee MR Using a Body Coil is Equivalent to CT in Measuring the TT-TG Distance: Removing the Systematic Bias.
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Aivazoglou LU, Toma MK, Arruda PHC, Ormond Filho AG, Guimarães JB, and Silva FD
- Abstract
Objective To compare magnetic resonance imaging (MRI) using a body coil with computed tomography (CT) in measuring the tibial tubercle-trochlear groove distance (TT-TG) and the patellar tendon-cartilaginous trochlear groove (PT-CTG) distances, and evaluate interrater reliability. Methods The study group consisted of 34 knees from 17 asymptomatic subjects with no history of knee pathology, trauma or surgery. A low-dose CT scan and an axial T1-weighted MRI sequence of the knees were performed with rigorous standardization of the positioning with full extension of the knees and parallel feet. Two musculoskeletal radiologists performed the measurements independently. The reliability of the TT-TG and PT-CTG distances on CT (17.1 ± 4.2 mm and 17.3 ± 4.2 mm) and of MRI (16.2 ± 3.7 mm and 16.5 ± 4.1 mm) was assessed by intraclass correlation coefficient (ICC [2,1]) and Bland-Altman graphs, as well as the interrater reliability for both methods. Results Good reliability and agreement was observed between CT and MRI measurements for TT-TG and PT-CTG, with an ICC of 0.774 ( p < 0.001) and 0.743 ( p < 0.001), respectively, and no systematic bias was observed. The interrater reliability was excellent for all measurements on both imaging methods. Conclusion This was the first study that compared MRI using a body coil with CT in measuring the TT-TG distance, with the potential clinical implication that the CT in this clinical setting could be avoided., Competing Interests: Conflito de Interesses Os autores não têm conflito de interesses a declarar., (Sociedade Brasileira de Ortopedia e Traumatologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ).)
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- 2021
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37. Osteoid osteoma: the great mimicker.
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Carneiro BC, Da Cruz IAN, Ormond Filho AG, Silva IP, Guimarães JB, Silva FD, Nico MAC, and Stump XMGRG
- Abstract
Osteoid osteoma is a painful, benign and common bone tumor that is prevalent in young adults. The typical clinical presentation consists of pain that becomes worse at night and is relieved by nonsteroidal anti-inflammatory drugs. The most common imaging finding is a lytic lesion, known as a nidus, with variable intralesional mineralization, accompanied by bone sclerosis, cortical thickening and surrounding bone marrow edema, as well as marked enhancement with intravenous contrast injection. When the lesion is located in typical locations (intracortical bone and the diaphyses of long bones), both characteristic clinical and radiological features are diagnostic. However, osteoid osteoma is a multifaceted pathology that can have unusual presentations, such as intraarticular osteoid osteoma, epiphyseal location, lesions at the extremities and multicentric nidi, and frequently present atypical clinical and radiological manifestations. In addition, many conditions may mimic osteoid osteoma and vice versa, leading to misdiagnosis. Therefore, it is essential to understand these musculoskeletal diseases and their imaging findings to increase diagnostic accuracy, enable early treatment and prevent poor prognosis.
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- 2021
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38. Effect of Physical Training on Exercise-Induced Inflammation and Performance in Mice.
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de Barcellos LAM, Gonçalves WA, Esteves de Oliveira MP, Guimarães JB, Queiroz-Junior CM, de Resende CB, Russo RC, Coimbra CC, Silva AN, Teixeira MM, Rezende BM, and Pinho V
- Abstract
Acute exercise increases the amount of circulating inflammatory cells and cytokines to maintain physiological homeostasis. However, it remains unclear how physical training regulates exercise-induced inflammation and performance. Here, we demonstrate that acute high intensity exercise promotes an inflammatory profile characterized by increased blood IL-6 levels, neutrophil migratory capacity, and leukocyte recruitment to skeletal muscle vessels. Moreover, we found that physical training amplified leukocyte-endothelial cell interaction induced by acute exercise in skeletal muscle vessels and diminished exercise-induced inflammation in skeletal muscle tissue. Furthermore, we verified that disruption of the gp-91 subunit of NADPH-oxidase inhibited exercise-induced leukocyte recruitment on skeletal muscle after training with enhanced exercise time until fatigue. In conclusion, the training was related to physical improvement and immune adaptations. Moreover, reactive oxygen species (ROS) could be related to mechanisms to limit aerobic performance and its absence decreases the inflammatory response elicited by exercise after training., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Barcellos, Gonçalves, Esteves de Oliveira, Guimarães, Queiroz-Junior, Resende, Russo, Coimbra, Silva, Teixeira, Rezende and Pinho.)
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- 2021
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39. The Role of Magnetic Resonance in the Diagnosis of Chronic Exertional Compartment Syndrome.
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Nico MAC, Carneiro BC, Zorzenoni FO, Ormond Filho AG, and Guimarães JB
- Abstract
Chronic compartment syndrome is a common and often underdiagnosed exercise-induced condition, accounting on average for a quarter of cases of chronic exertional pain in the leg, second only to the fracture/tibial stress syndrome spectrum. It traditionally occurs in young runner athletes, although more recent studies have demonstrated a considerable prevalence in low-performance practitioners of physical activity, even in middle-aged or elderly patients. The list of differential diagnoses is extensive, and sometimes it is difficult to distinguish them only by the clinical data, and subsidiary examinations are required. The diagnosis is classically made by the clinical picture, by exclusion of the differential diagnoses, and through the measurement of the intracompartmental pressure. Although needle manometry is considered the gold standard in the diagnosis, its use is not universally accepted, since there are some important limitations, apart from the restricted availability of the needle equipment in Brazil. New protocols of manometry have recently been proposed to overcome the deficiency of the traditional ones, and some of them recommend the systematic use of magnetic resonance imaging (MRI) in the exclusion of differential diagnoses. The use of post-effort liquid-sensitive MRI sequences is a good noninvasive option instead of needle manometry in the diagnosis of chronic compartment syndrome, since the increase in post-exercise signal intensity is statistically significant when compared with manometry pressure values in asymptomatic patients and in those with the syndrome; hence, the test can be used in the diagnostic criteria. The definitive treatment is fasciotomy, although there are less effective alternatives., Competing Interests: Conflito de Interesses Os autores declaram não haver conflito de interesses., (Sociedade Brasileira de Ortopedia e Traumatologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ).)
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- 2020
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40. Multimodality Imaging of Foreign Bodies: New Insights into Old Challenges.
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Carneiro BC, Cruz IAN, Chemin RN, Rizzetto TA, Guimarães JB, Silva FD, Junior CY, Pastore D, Ormond Filho AG, and Nico MAC
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- Humans, Foreign Bodies diagnostic imaging, Multimodal Imaging, Wounds and Injuries diagnostic imaging
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Traumatic wounds and lacerations are a common reason for patients to present to emergency departments, with retained foreign bodies (FBs) accounting for 7%-15% of cases, particularly those involving the extremities. These retained materials result in a granulomatous tissue response known as an FB reaction, a pathologic attempt to isolate the FB from the host. The most common FB materials are glass, metal, and wood, but other compositions can also be found, such as plastic and animal-derived materials. Clinical history, physical examination, and wound exploration are essential in investigation of retained material but are not sufficient to exclude an FB, and additional investigation is required. Imaging evaluation is a useful tool to help depict and locate an FB, assess possible complications, and guide removal. Conventional radiography, the first-line method in this scenario, is a widely available low-cost depiction method that has good sensitivity for depicting FBs. If the retained material is not depicted at conventional radiography, US can be performed. US is highly sensitive in depicting both radiolucent and radiopaque FBs in superficial locations. For deeper objects, CT may be necessary. MRI is the best imaging modality to delineate local soft-tissue and osseous complications. Retained FBs can result in early and delayed complications, with infection being the most frequent complication. To avoid preventable morbidities related to FBs, radiologists should be familiar with imaging findings and provide essential information to help the attending physician treat each patient. Online supplemental material is available for this article .
© RSNA, 2020.- Published
- 2020
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41. STIR and diffusion-weighted MRI in asymptomatic hyperCKemia caused by ANO5-related myopathy.
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Silva AMS, GuimarÃes JB, Machado FCN, and Zanoteli E
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- Anoctamins, Diffusion Magnetic Resonance Imaging, Humans, Muscular Diseases diagnostic imaging
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- 2020
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42. NLR and Intestinal Dysbiosis-Associated Inflammatory Illness: Drivers or Dampers?
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Elias-Oliveira J, Leite JA, Pereira ÍS, Guimarães JB, Manso GMDC, Silva JS, Tostes RC, and Carlos D
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- Animals, Humans, Dysbiosis immunology, Gastrointestinal Microbiome immunology, Inflammation immunology, NLR Proteins immunology
- Abstract
The intestinal microbiome maintains a close relationship with the host immunity. This connection fosters a health state by direct and indirect mechanisms. Direct influences occur mainly through the production of short-chain fatty acids (SCFAs), gastrointestinal hormones and precursors of bioactive molecules. Indirect mechanisms comprise the crosstalk between bacterial products and the host's innate immune system. Conversely, intestinal dysbiosis is a condition found in a large number of chronic intestinal inflammatory diseases, such as ulcerative colitis and Crohn's disease, as well as in diseases associated with low-grade inflammation, such as obesity, type 1 and 2 diabetes mellitus and cardiovascular diseases. NOD-Like receptors (NLRs) are cytoplasmic receptors expressed by adaptive and innate immune cells that form a multiprotein complex, termed the inflammasome, responsible for the release of mature interleukin (IL)-1β and IL-18. NLRs are also involved in the recognition of bacterial components and production of antimicrobial molecules that shape the gut microbiota and maintain the intestinal homeostasis. Recent novel findings show that NLRs may act as positive or negative regulators of inflammation by modulating NF-κB activation. This mini-review presents current and updated evidence on the interplay between NLRs and gut microbiota and their dual role, contributing to progression or conferring protection, in diabetes and other inflammatory diseases., (Copyright © 2020 Elias-Oliveira, Leite, Pereira, Guimarães, Manso, Silva, Tostes and Carlos.)
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- 2020
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43. A spatial stream-network approach assists in managing the remnant genetic diversity of riparian forests.
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Rodríguez-González PM, García C, Albuquerque A, Monteiro-Henriques T, Faria C, Guimarães JB, Mendonça D, Simões F, Ferreira MT, Mendes A, Matos J, and Almeida MH
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- Ecology, Models, Theoretical, Forests, Genetic Variation, Genetics, Population, Trees classification, Trees genetics
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Quantifying the genetic diversity of riparian trees is essential to understand their chances to survive hydroclimatic alterations and to maintain their role as foundation species modulating fluvial ecosystem processes. However, the application of suitable models that account for the specific dendritic structure of hydrographic networks is still incipient in the literature. We investigate the roles of ecological and spatial factors in driving the genetic diversity of Salix salviifolia, an Iberian endemic riparian tree, across the species latitudinal range. We applied spatial stream-network models that aptly integrate dendritic features (topology, directionality) to quantify the impacts of multiple scale factors in determining genetic diversity. Based on the drift hypothesis, we expect that genetic diversity accumulates downstream in riparian ecosystems, but life history traits (e.g. dispersal patterns) and abiotic or anthropogenic factors (e.g. drought events or hydrological alteration) might alter expected patterns. Hydrological factors explained the downstream accumulation of genetic diversity at the intermediate scale that was likely mediated by hydrochory. The models also suggested upstream gene flow within basins that likely occurred through anemophilous and entomophilous pollen and seed dispersal. Higher thermicity and summer drought were related to higher population inbreeding and individual homozygosity, respectively, suggesting that increased aridity might disrupt the connectivity and mating patterns among and within riparian populations.
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- 2019
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44. Diagnostic Imaging of Inflammatory Myopathies: New Concepts and a Radiological Approach.
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Guimarães JB, Nico MA, Omond AG, Aivazoglou LU, Jorge RB, Zanoteli E, and Fernandes ARC
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- Adipose Tissue diagnostic imaging, Dermatomyositis diagnostic imaging, Edema diagnostic imaging, Eosinophilia diagnostic imaging, Fasciitis diagnostic imaging, Humans, Magnetic Resonance Imaging, Myositis, Inclusion Body diagnostic imaging, Myotoxicity diagnostic imaging, Polymyositis diagnostic imaging, Ultrasonography, Whole Body Imaging, Muscle, Skeletal diagnostic imaging, Myositis diagnostic imaging
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Purpose of Review: The purpose of this review article is to highlight the current role of diagnostic imaging in the assessment of inflammatory myopathies., Recent Findings: Recent research demonstrates that imaging plays an important role in evaluating patients with symptoms of an inflammatory myopathy. In general, MRI is the pivotal imaging modality for assessing inflammatory myopathies, revealing precise anatomic details because of changes in the signal intensity of the muscles. Whole-body MR imaging has become increasingly important over the last several years. US is also a valuable imaging modality for scanning muscles. Together with the clinical history, familiarity with the imaging features of inflammatory myopathies is essential for formulating an accurate diagnosis.
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- 2019
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45. Clinical and imaging hallmarks of the MYH7-related myopathy with severe axial involvement.
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Dabaj I, Carlier RY, Gómez-Andrés D, Neto OA, Bertini E, D'amico A, Fattori F, PéRéon Y, Castiglioni C, Rodillo E, Catteruccia M, Guimarães JB, Oliveira ASB, Reed UC, Mesrob L, Lechner D, Boland A, Deleuze JF, Malfatti E, Bonnemann C, Laporte J, Romero N, Felter A, Quijano-Roy S, Moreno CAM, and Zanoteli E
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- Adolescent, Adult, Biopsy, Child, Electrodiagnosis, Female, Humans, Magnetic Resonance Imaging, Male, Muscle, Skeletal diagnostic imaging, Muscle, Skeletal pathology, Muscular Diseases physiopathology, Mutation, Mutation, Missense, Spine diagnostic imaging, Young Adult, Cardiac Myosins genetics, Muscular Diseases diagnostic imaging, Muscular Diseases genetics, Myosin Heavy Chains genetics
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Introduction: MYH7 gene mutations are related to a heterogeneous group of skeletal and cardiac myopathies., Methods: We evaluated clinical and muscle MRI changes in patients with mutations in the rod domain of MYH7, including 1 with mosaicism and 3 with novel missense mutations., Results: Patients presented in childhood with a distal and axial phenotype. Biopsy findings were variable. Half of the cases displaying some type of core pathology, including minicores and eccentric cores. Most patients demonstrated internal bands of infiltration ("inverted-collagen-VI sign") in multiple muscles, particularly the soleus, and prominent atrophy and fatty infiltration of the tongue and the paraspinal, gluteus minimus, sartorius, gracilis, tibialis anterior, and extensor digitorum longus muscles., Discussion: Muscle imaging findings in patients with axial involvement provide significant clues permitting the distinction between MYH7-related myopathies and other axial myopathies such as those related to SEPN1 and LMNA genes. Muscle Nerve 58: 224-234, 2018., (© 2018 Wiley Periodicals, Inc.)
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- 2018
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46. The draft genome sequence of cork oak.
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Ramos AM, Usié A, Barbosa P, Barros PM, Capote T, Chaves I, Simões F, Abreu I, Carrasquinho I, Faro C, Guimarães JB, Mendonça D, Nóbrega F, Rodrigues L, Saibo NJM, Varela MC, Egas C, Matos J, Miguel CM, Oliveira MM, Ricardo CP, and Gonçalves S
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- Sequence Analysis, DNA, Genome, Plant, Quercus genetics
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Cork oak (Quercus suber) is native to southwest Europe and northwest Africa where it plays a crucial environmental and economical role. To tackle the cork oak production and industrial challenges, advanced research is imperative but dependent on the availability of a sequenced genome. To address this, we produced the first draft version of the cork oak genome. We followed a de novo assembly strategy based on high-throughput sequence data, which generated a draft genome comprising 23,347 scaffolds and 953.3 Mb in size. A total of 79,752 genes and 83,814 transcripts were predicted, including 33,658 high-confidence genes. An InterPro signature assignment was detected for 69,218 transcripts, which represented 82.6% of the total. Validation studies demonstrated the genome assembly and annotation completeness and highlighted the usefulness of the draft genome for read mapping of high-throughput sequence data generated using different protocols. All data generated is available through the public databases where it was deposited, being therefore ready to use by the academic and industry communities working on cork oak and/or related species.
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- 2018
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47. Common and variable clinical, histological, and imaging findings of recessive RYR1-related centronuclear myopathy patients.
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Abath Neto O, Moreno CAM, Malfatti E, Donkervoort S, Böhm J, Guimarães JB, Foley AR, Mohassel P, Dastgir J, Bharucha-Goebel DX, Monges S, Lubieniecki F, Collins J, Medne L, Santi M, Yum S, Banwell B, Salort-Campana E, Rendu J, Fauré J, Yis U, Eymard B, Cheraud C, Schneider R, Thompson J, Lornage X, Mesrob L, Lechner D, Boland A, Deleuze JF, Reed UC, Oliveira ASB, Biancalana V, Romero NB, Bönnemann CG, Laporte J, and Zanoteli E
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- Adolescent, Adult, Child, Child, Preschool, Cohort Studies, Female, Humans, Infant, Male, Middle Aged, Muscle, Skeletal diagnostic imaging, Muscle, Skeletal pathology, Mutation, Myopathies, Structural, Congenital genetics, Myopathies, Structural, Congenital physiopathology, Phenotype, Myopathies, Structural, Congenital diagnostic imaging, Myopathies, Structural, Congenital pathology, Ryanodine Receptor Calcium Release Channel genetics
- Abstract
Mutations in RYR1 give rise to diverse skeletal muscle phenotypes, ranging from classical central core disease to susceptibility to malignant hyperthermia. Next-generation sequencing has recently shown that RYR1 is implicated in a wide variety of additional myopathies, including centronuclear myopathy. In this work, we established an international cohort of 21 patients from 18 families with autosomal recessive RYR1-related centronuclear myopathy, to better define the clinical, imaging, and histological spectrum of this disorder. Early onset of symptoms with hypotonia, motor developmental delay, proximal muscle weakness, and a stable course were common clinical features in the cohort. Ptosis and/or ophthalmoparesis, facial weakness, thoracic deformities, and spinal involvement were also frequent but variable. A common imaging pattern consisted of selective involvement of the vastus lateralis, adductor magnus, and biceps brachii in comparison to adjacent muscles. In addition to a variable prominence of central nuclei, muscle biopsy from 20 patients showed type 1 fiber predominance and a wide range of intermyofibrillary architecture abnormalities. All families harbored compound heterozygous mutations, most commonly a truncating mutation combined with a missense mutation. This work expands the phenotypic characterization of patients with recessive RYR1-related centronuclear myopathy by highlighting common and variable clinical, histological, and imaging findings in these patients., (Copyright © 2017 Elsevier B.V. All rights reserved.)
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- 2017
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48. The performance of the jet trigger for the ATLAS detector during 2011 data taking.
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Aad G, Abbott B, Abdallah J, Abdinov O, Abeloos B, Aben R, Abolins M, AbouZeid OS, Abraham NL, Abramowicz H, Abreu H, Abreu R, Abulaiti Y, Acharya BS, Adamczyk L, Adams DL, Adelman J, Adomeit S, Adye T, Affolder AA, Agatonovic-Jovin T, Agricola J, Aguilar-Saavedra JA, Ahlen SP, Ahmadov F, Aielli G, Akerstedt H, Åkesson TP, Akimov AV, Alberghi GL, Albert J, Albrand S, Verzini MJ, Aleksa M, Aleksandrov IN, Alexa C, Alexander G, Alexopoulos T, Alhroob M, Aliev M, Alimonti G, Alison J, Alkire SP, Allbrooke BM, Allen BW, Allport PP, Aloisio A, Alonso A, Alonso F, Alpigiani C, Gonzalez BA, Piqueras DÁ, Alviggi MG, Amadio BT, Amako K, Coutinho YA, Amelung C, Amidei D, Santos SP, Amorim A, Amoroso S, Amram N, Amundsen G, Anastopoulos C, Ancu LS, Andari N, Andeen T, Anders CF, Anders G, Anders JK, Anderson KJ, Andreazza A, Andrei V, Angelidakis S, Angelozzi I, Anger P, Angerami A, Anghinolfi F, Anisenkov AV, Anjos N, Annovi A, Antonelli M, Antonov A, Antos J, Anulli F, Aoki M, Bella LA, Arabidze G, Arai Y, Araque JP, Arce AT, Arduh FA, Arguin JF, Argyropoulos S, Arik M, Armbruster AJ, Armitage LJ, Arnaez O, Arnold H, Arratia M, Arslan O, Artamonov A, Artoni G, Artz S, Asai S, Asbah N, Ashkenazi A, Åsman B, Asquith L, Assamagan K, Astalos R, Atkinson M, Atlay NB, Augsten K, Avolio G, Axen B, Ayoub MK, Azuelos G, Baak MA, Baas AE, Baca MJ, Bachacou H, Bachas K, Backes M, Backhaus M, Bagiacchi P, Bagnaia P, Bai Y, Baines JT, Baker OK, Baldin EM, Balek P, Balestri T, Balli F, Balunas WK, Banas E, Banerjee S, Bannoura AA, Barak L, Barberio EL, Barberis D, Barbero M, Barillari T, Barklow T, Barlow N, Barnes SL, Barnett BM, Barnett RM, Barnovska Z, Baroncelli A, Barone G, Barr AJ, Navarro LB, Barreiro F, da Costa JB, Bartoldus R, Barton AE, Bartos P, Basalaev A, Bassalat A, Basye A, Bates RL, Batista SJ, Batley JR, Battaglia M, Bauce M, Bauer F, Bawa HS, Beacham JB, Beattie MD, Beau T, Beauchemin PH, Bechtle P, Beck HP, Becker K, Becker M, Beckingham M, Becot C, Beddall AJ, Beddall A, Bednyakov VA, Bedognetti M, Bee CP, Beemster LJ, Beermann TA, Begel M, Behr JK, Belanger-Champagne C, Bell AS, Bella G, Bellagamba L, Bellerive A, Bellomo M, Belotskiy K, Beltramello O, Belyaev NL, Benary O, Benchekroun D, Bender M, Bendtz K, Benekos N, Benhammou Y, Noccioli EB, Benitez J, Garcia JA, Benjamin DP, Bensinger JR, Bentvelsen S, Beresford L, Beretta M, Berge D, Kuutmann EB, Berger N, Berghaus F, Beringer J, Berlendis S, Bernard NR, Bernius C, Bernlochner FU, Berry T, Berta P, Bertella C, Bertoli G, Bertolucci F, Bertram IA, Bertsche C, Bertsche D, Besjes GJ, Bylund OB, Bessner M, Besson N, Betancourt C, Bethke S, Bevan AJ, Bhimji W, Bianchi RM, Bianchini L, Bianco M, Biebel O, Biedermann D, Bielski R, Biesuz NV, Biglietti M, De Mendizabal JB, Bilokon H, Bindi M, Binet S, Bingul A, Bini C, Biondi S, Bjergaard DM, Black CW, Black JE, Black KM, Blackburn D, Blair RE, Blanchard JB, Blanco JE, Blazek T, Bloch I, Blocker C, Blum W, Blumenschein U, Blunier S, Bobbink GJ, Bobrovnikov VS, Bocchetta SS, Bocci A, Bock C, Boehler M, Boerner D, Bogaerts JA, Bogavac D, Bogdanchikov AG, Bohm C, Boisvert V, Bold T, Boldea V, Boldyrev AS, Bomben M, Bona M, Boonekamp M, Borisov A, Borissov G, Bortfeldt J, Bortoletto D, Bortolotto V, Bos K, Boscherini D, Bosman M, Sola JD, Boudreau J, Bouffard J, Bouhova-Thacker EV, Boumediene D, Bourdarios C, Boutle SK, Boveia A, Boyd J, Boyko IR, Bracinik J, Brandt A, Brandt G, Brandt O, Bratzler U, Brau B, Brau JE, Braun HM, Madden WD, Brendlinger K, Brennan AJ, Brenner L, Brenner R, Bressler S, Bristow TM, Britton D, Britzger D, Brochu FM, Brock I, Brock R, Brooijmans G, Brooks T, Brooks WK, Brosamer J, Brost E, Broughton JH, de Renstrom PA, Bruncko D, Bruneliere R, Bruni A, Bruni G, Brunt BH, Bruschi M, Bruscino N, Bryant P, Bryngemark L, Buanes T, Buat Q, Buchholz P, Buckley AG, Budagov IA, Buehrer F, Bugge MK, Bulekov O, Bullock D, Burckhart H, Burdin S, Burgard CD, Burghgrave B, Burka K, Burke S, Burmeister I, Busato E, Büscher D, Büscher V, Bussey P, Butler JM, Butt AI, Buttar CM, Butterworth JM, Butti P, Buttinger W, Buzatu A, Buzykaev AR, Urbán SC, Caforio D, Cairo VM, Cakir O, Calace N, Calafiura P, Calandri A, Calderini G, Calfayan P, Caloba LP, Calvet D, Calvet S, Calvet TP, Toro RC, Camarda S, Camarri P, Cameron D, Armadans RC, Camincher C, Campana S, Campanelli M, Campoverde A, Canale V, Canepa A, Bret MC, Cantero J, Cantrill R, Cao T, Garrido MD, Caprini I, Caprini M, Capua M, Caputo R, Carbone RM, Cardarelli R, Cardillo F, Carli I, Carli T, Carlino G, Carminati L, Caron S, Carquin E, Carrillo-Montoya GD, Carter JR, Carvalho J, Casadei D, Casado MP, Casolino M, Casper DW, Castaneda-Miranda E, Castelli A, Gimenez VC, Castro NF, Catinaccio A, Catmore JR, Cattai A, Caudron J, Cavaliere V, Cavallaro E, Cavalli D, Cavalli-Sforza M, Cavasinni V, Ceradini F, Alberich LC, Cerio BC, Cerqueira AS, Cerri A, Cerrito L, Cerutti F, Cerv M, Cervelli A, Cetin SA, Chafaq A, Chakraborty D, Chan SK, Chan YL, Chang P, Chapman JD, Charlton DG, Chatterjee A, Chau CC, Barajas CA, Che S, Cheatham S, Chegwidden A, Chekanov S, Chekulaev SV, Chelkov GA, Chelstowska MA, Chen C, Chen H, Chen K, Chen S, Chen S, Chen X, Chen Y, Cheng HC, Cheng HJ, Cheng Y, Cheplakov A, Cheremushkina E, Moursli RC, Chernyatin V, Cheu E, Chevalier L, Chiarella V, Chiarelli G, Chiodini G, Chisholm AS, Chitan A, Chizhov MV, Choi K, Chomont AR, Chouridou S, Chow BK, Christodoulou V, Chromek-Burckhart D, Chudoba J, Chuinard AJ, Chwastowski JJ, Chytka L, Ciapetti G, Ciftci AK, Cinca D, Cindro V, Cioara IA, Ciocio A, Cirotto F, Citron ZH, Ciubancan M, Clark A, Clark BL, Clark MR, Clark PJ, Clarke RN, Clement C, Coadou Y, Cobal M, Coccaro A, Cochran J, Coffey L, Colasurdo L, Cole B, Cole S, Colijn AP, Collot J, Colombo T, Compostella G, Muiño PC, Coniavitis E, Connell SH, Connelly IA, Consorti V, Constantinescu S, Conta C, Conti G, Conventi F, Cooke M, Cooper BD, Cooper-Sarkar AM, Cornelissen T, Corradi M, Corriveau F, Corso-Radu A, Cortes-Gonzalez A, Cortiana G, Costa G, Costa MJ, Costanzo D, Cottin G, Cowan G, Cox BE, Cranmer K, Crawley SJ, Cree G, Crépé-Renaudin S, Crescioli F, Cribbs WA, Ortuzar MC, Cristinziani M, Croft V, Crosetti G, Donszelmann TC, Cummings J, Curatolo M, Cúth J, Cuthbert C, Czirr H, Czodrowski P, D'Auria S, D'Onofrio M, De Sousa MJ, Via CD, Dabrowski W, Dai T, Dale O, Dallaire F, Dallapiccola C, Dam M, Dandoy JR, Dang NP, Daniells AC, Dann NS, Danninger M, Hoffmann MD, Dao V, Darbo G, Darmora S, Dassoulas J, Dattagupta A, Davey W, David C, Davidek T, Davies M, Davison P, Davygora Y, Dawe E, Dawson I, Daya-Ishmukhametova RK, De K, de Asmundis R, De Benedetti A, De Castro S, De Cecco S, De Groot N, de Jong P, De la Torre H, De Lorenzi F, De Pedis D, De Salvo A, De Sanctis U, De Santo A, De Regie JB, Dearnaley WJ, Debbe R, Debenedetti C, Dedovich DV, Deigaard I, Del Peso J, Del Prete T, Delgove D, Deliot F, Delitzsch CM, Deliyergiyev M, Dell'Acqua A, Dell'Asta L, Dell'Orso M, Della Pietra M, Della Volpe D, Delmastro M, Delsart PA, Deluca C, DeMarco DA, Demers S, Demichev M, Demilly A, Denisov SP, Denysiuk D, Derendarz D, Derkaoui JE, Derue F, Dervan P, Desch K, Deterre C, Dette K, Deviveiros PO, Dewhurst A, Dhaliwal S, Di Ciaccio A, Di Ciaccio L, Di Clemente WK, Di Donato C, Di Girolamo A, Di Girolamo B, Di Micco B, Di Nardo R, Di Simone A, Di Sipio R, Di Valentino D, Diaconu C, Diamond M, Dias FA, Diaz MA, Diehl EB, Dietrich J, Diglio S, Dimitrievska A, Dingfelder J, Dita P, Dita S, Dittus F, Djama F, Djobava T, Djuvsland JI, do Vale MA, Dobos D, Dobre M, Doglioni C, Dohmae T, Dolejsi J, Dolezal Z, Dolgoshein BA, Donadelli M, Donati S, Dondero P, Donini J, Dopke J, Doria A, Dova MT, Doyle AT, Drechsler E, Dris M, Du Y, Duarte-Campderros J, Duchovni E, Duckeck G, Ducu OA, Duda D, Dudarev A, Duflot L, Duguid L, Dührssen M, Dunford M, Yildiz HD, Düren M, Durglishvili A, Duschinger D, Dutta B, Dyndal M, Eckardt C, Ecker KM, Edgar RC, Edson W, Edwards NC, Eifert T, Eigen G, Einsweiler K, Ekelof T, Kacimi ME, Ellajosyula V, Ellert M, Elles S, Ellinghaus F, Elliot AA, Ellis N, Elmsheuser J, Elsing M, Emeliyanov D, Enari Y, Endner OC, Endo M, Ennis JS, Erdmann J, Ereditato A, Ernis G, Ernst J, Ernst M, Errede S, Ertel E, Escalier M, Esch H, Escobar C, Esposito B, Etienvre AI, Etzion E, Evans H, Ezhilov A, Fabbri F, Fabbri L, Facini G, Fakhrutdinov RM, Falciano S, Falla RJ, Faltova J, Fang Y, Fanti M, Farbin A, Farilla A, Farina C, Farooque T, Farrell S, Farrington SM, Farthouat P, Fassi F, Fassnacht P, Fassouliotis D, Giannelli MF, Favareto A, Fawcett WJ, Fayard L, Fedin OL, Fedorko W, Feigl S, Feligioni L, Feng C, Feng EJ, Feng H, Fenyuk AB, Feremenga L, Martinez PF, Perez SF, Ferrando J, Ferrari A, Ferrari P, Ferrari R, de Lima DE, Ferrer A, Ferrere D, Ferretti C, Parodi AF, Fiedler F, Filipčič A, Filipuzzi M, Filthaut F, Fincke-Keeler M, Finelli KD, Fiolhais MC, Fiorini L, Firan A, Fischer A, Fischer C, Fischer J, Fisher WC, Flaschel N, Fleck I, Fleischmann P, Fletcher GT, Fletcher G, Fletcher RR, Flick T, Floderus A, Castillo LR, Flowerdew MJ, Forcolin GT, Formica A, Forti A, Foster AG, Fournier D, Fox H, Fracchia S, Francavilla P, Franchini M, Francis D, Franconi L, Franklin M, Frate M, Fraternali M, Freeborn D, Fressard-Batraneanu SM, Friedrich F, Froidevaux D, Frost JA, Fukunaga C, Torregrosa EF, Fusayasu T, Fuster J, Gabaldon C, Gabizon O, Gabrielli A, Gabrielli A, Gach GP, Gadatsch S, Gadomski S, Gagliardi G, Gagnon LG, Gagnon P, Galea C, Galhardo B, Gallas EJ, Gallop BJ, Gallus P, Galster G, Gan KK, Gao J, Gao Y, Gao YS, Walls FM, García C, Navarro JE, Garcia-Sciveres M, Gardner RW, Garelli N, Garonne V, Bravo AG, Gatti C, Gaudiello A, Gaudio G, Gaur B, Gauthier L, Gavrilenko IL, Gay C, Gaycken G, Gazis EN, Gecse Z, Gee CN, Geich-Gimbel C, Geisler MP, Gemme C, Genest MH, Geng C, Gentile S, George S, Gerbaudo D, Gershon A, Ghasemi S, Ghazlane H, Ghneimat M, Giacobbe B, Giagu S, Giannetti P, Gibbard B, Gibson SM, 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- Abstract
The performance of the jet trigger for the ATLAS detector at the LHC during the 2011 data taking period is described. During 2011 the LHC provided proton-proton collisions with a centre-of-mass energy of 7 TeV and heavy ion collisions with a 2.76 TeV per nucleon-nucleon collision energy. The ATLAS trigger is a three level system designed to reduce the rate of events from the 40 MHz nominal maximum bunch crossing rate to the approximate 400 Hz which can be written to offline storage. The ATLAS jet trigger is the primary means for the online selection of events containing jets. Events are accepted by the trigger if they contain one or more jets above some transverse energy threshold. During 2011 data taking the jet trigger was fully efficient for jets with transverse energy above 25 GeV for triggers seeded randomly at Level 1. For triggers which require a jet to be identified at each of the three trigger levels, full efficiency is reached for offline jets with transverse energy above 60 GeV. Jets reconstructed in the final trigger level and corresponding to offline jets with transverse energy greater than 60 GeV, are reconstructed with a resolution in transverse energy with respect to offline jets, of better than 4 % in the central region and better than 2.5 % in the forward direction.
- Published
- 2016
- Full Text
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49. Search for the Higgs boson produced in association with a W boson and decaying to four b -quarks via two spin-zero particles in pp collisions at 13 TeV with the ATLAS detector.
- Author
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- Abstract
This paper presents a dedicated search for exotic decays of the Higgs boson to a pair of new spin-zero particles, [Formula: see text], where the particle a decays to b -quarks and has a mass in the range of 20-60 GeV. The search is performed in events where the Higgs boson is produced in association with a [Formula: see text] boson, giving rise to a signature of a lepton (electron or muon), missing transverse momentum, and multiple jets from b -quark decays. The analysis is based on the full dataset of pp collisions at [Formula: see text] recorded in 2015 by the ATLAS detector at the CERN Large Hadron Collider, corresponding to an integrated luminosity of 3.2 [Formula: see text]. No significant excess of events above the Standard Model prediction is observed, and a [Formula: see text] confidence-level upper limit is derived for the product of the production cross section for [Formula: see text] times the branching ratio for the decay [Formula: see text]. The upper limit ranges from 6.2 pb for an a -boson mass [Formula: see text] to 1.5 pb for [Formula: see text].
- Published
- 2016
- Full Text
- View/download PDF
50. Thermoregulatory responses in exercising rats: methodological aspects and relevance to human physiology.
- Author
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Wanner SP, Prímola-Gomes TN, Pires W, Guimarães JB, Hudson AS, Kunstetter AC, Fonseca CG, Drummond LR, Damasceno WC, and Teixeira-Coelho F
- Abstract
Rats are used worldwide in experiments that aim to investigate the physiological responses induced by a physical exercise session. Changes in body temperature regulation, which may affect both the performance and the health of exercising rats, are evident among these physiological responses. Despite the universal use of rats in biomedical research involving exercise, investigators often overlook important methodological issues that hamper the accurate measurement of clear thermoregulatory responses. Moreover, much debate exists regarding whether the outcome of rat experiments can be extrapolated to human physiology, including thermal physiology. Herein, we described the impact of different exercise intensities, durations and protocols and environmental conditions on running-induced thermoregulatory changes. We focused on treadmill running because this type of exercise allows for precise control of the exercise intensity and the measurement of autonomic thermoeffectors associated with heat production and loss. Some methodological issues regarding rat experiments, such as the sites for body temperature measurements and the time of day at which experiments are performed, were also discussed. In addition, we analyzed the influence of a high body surface area-to-mass ratio and limited evaporative cooling on the exercise-induced thermoregulatory responses of running rats and then compared these responses in rats to those observed in humans. Collectively, the data presented in this review represent a reference source for investigators interested in studying exercise thermoregulation in rats. In addition, the present data indicate that the thermoregulatory responses of exercising rats can be extrapolated, with some important limitations, to human thermal physiology.
- Published
- 2015
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