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Your search keyword '"Guimarães, Nayara Felipe"' showing total 2 results
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2 results on '"Guimarães, Nayara Felipe"'

1. Nanocapsules for the co-delivery of selol and doxorubicin to breast adenocarcinoma 4T1 cells in vitro

Author

Ganassin, Rayane, primary, Merker, Carolin, additional, Rodrigues, Mosar Corrêa, additional, Guimarães, Nayara Felipe, additional, Sodré, Carine Sampaio Cerqueira, additional, Ferreira, Queila da Silva, additional, da Silva, Sebastião William, additional, Ombredane, Alicia Simalie, additional, Joanitti, Graziella Anselmo, additional, Py-Daniel, Karen Rapp, additional, Zhang, Juan, additional, Jiang, Cheng-Shi, additional, de Morais, Paulo César, additional, Mosiniewicz-Szablewska, Ewa, additional, Suchocki, Piotr, additional, Longo, João Paulo Figueiró, additional, Meijer, Jan, additional, Estrela-Lopis, Irina, additional, de Azevedo, Ricardo Bentes, additional, and Muehlmann, Luis Alexandre, additional more...

Published
2017
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2. Nanocapsules for the co-delivery of selol and doxorubicin to breast adenocarcinoma 4T1 cells in vitro.

Author

Ganassin, Rayane, Merker, Carolin, Rodrigues, Mosar Corrêa, Guimarães, Nayara Felipe, Sodré, Carine Sampaio Cerqueira, Ferreira, Queila da Silva, da Silva, Sebastião William, Ombredane, Alicia Simalie, Joanitti, Graziella Anselmo, Py-Daniel, Karen Rapp, Zhang, Juan, Jiang, Cheng-Shi, de Morais, Paulo César, Mosiniewicz-Szablewska, Ewa, Suchocki, Piotr, Longo, João Paulo Figueiró, Meijer, Jan, Estrela-Lopis, Irina, de Azevedo, Ricardo Bentes, and Muehlmann, Luis Alexandre more...

Subjects
DOXORUBICIN, BREAST cancer
Abstract

Nanocapsules (NCS-DOX) with an oily core of selol and a shell of poly(methyl vinyl ether-co-maleic anhydride) covalently conjugated to doxorubicin were developed. These nanocapsules are spherical, with an average hydrodynamic diameter of about 170 nm, and with negative zeta potential. NCS-DOX effectively co-delivered the selol and the doxorubicin into 4T1 cells and changed the intracellular distribution of DOX from the nuclei to the mitochondria. Moreover, a significantly increased cytotoxicity against 4T1 cells was observed, which is suggestive of additive or synergic effect of selol and doxorubicin. In conclusion, PVM/MA nanocapsules are suitable platforms to co-deliver drugs into cancer cells. [ABSTRACT FROM AUTHOR] more...

Published
2018
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