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3. A Systematic Evaluation of Game Elements Effects on Students' Motivation

Author

Leitão, Rui, Maguire, Martin, Turner, Sarah, and Guimarães, Laura

Abstract

Motivation theory is indispensable when discussing processes of learning. Learners who are motivated can learn almost everything. Students' motivation is probably one of the most important factors for teacher effectiveness both for engagement in the learning process and high academic performance. To have effective environmental education, it is not only necessary to inform the public about the ocean but also to involve and engage them is essential. Motivation and engagement are some of the most commonly mentioned concepts in gamification, thus, a gamified application seems to have the necessary features to improve the motivation of students in the learning context of Ocean Literacy topics. The main aims of this work were: i) to understand through a systematic evaluation, how game elements affect the different motivation layers; and ii) to compare them in terms of enhancing the motivation to recycle among secondary school students (11-14 years). To measure students' motivation, a pre-test and a post-test using a recycling situational motivation survey were administered in a classroom environment in Portugal and the UK. Findings show a trend regarding the effect of game elements mainly on the most autonomous forms of motivation. The different game elements, each one with different degrees of effects, were shown to have potential to increase motivation.

Published
2022
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4. Ocean Literacy Gamified: A Systematic Evaluation of the Effect of Game Elements on Students' Learning Experience

Author

Leitão, Rui, Maguire, Martin, Turner, Sarah, Arenas, Francisco, and Guimarães, Laura

Abstract

Low levels of concern about anthropogenic climate change have been attributed to a range of factors, some of which relate to education. These include people's lack of understanding and engagement with the multifaceted nature and extent of the problem that it presents to current and future generations. Limited knowledge is also known to be an obstacle to individual behaviour change, with important implications for young people's perceptions of the urgency to act and awareness of the consequences of their own behaviours. In this study, we explored ways to address low levels of understanding about ocean science dimensions to climate change phenomena, cognisant of a growing awareness that formal education curricula do not adequately engage young people with developing ocean literacy. Participants were a sample of secondary school students (11 to 14 years) in Portugal and the UK. Using a gamified mobile application, it was examined relationships between the use of different game elements such as points, badges and leaderboards, and learning outcomes. Systematic evaluation of each element shows how different game features affected the participants' learning experience and learning outcomes. Implications for formal and informal marine education, climate education, and how to improve ocean literacy efforts, are also discussed.

Published
2022
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6. Recent advances in the 3D skin bioprinting for regenerative medicine: Cells, biomaterials, and methods.

Author

Carvalho, Loyna Nobile, Peres, Lucas Correia, Alonso-Goulart, Vivian, Santos, Beatriz Jardim dos, Braga, Mário Fernando Alves, Campos, Felipe dos Anjos Rodrigues, Palis, Gabriela de Aquino Pinto, Quirino, Ludmilla Sousa, Guimarães, Laura Duarte, Lafetá, Sofia Alencar, Simbara, Márcia Mayumi Omi, and Castro-Filice, Letícia de Souza

Subjects
BIOPRINTING, REGENERATIVE medicine, TISSUE engineering, BIOMATERIALS, BODY weight, SKIN regeneration
Abstract

The skin is a tissue constantly exposed to the risk of damage, such as cuts, burns, and genetic disorders. The standard treatment is autograft, but it can cause pain to the patient being extremely complex in patients suffering from burns on large body surfaces. Considering that there is a need to develop technologies for the repair of skin tissue like 3D bioprinting. Skin is a tissue that is approximately 1/16 of the total body weight and has three main layers: epidermis, dermis, and hypodermis. Therefore, there are several studies using cells, biomaterials, and bioprinting for skin regeneration. Here, we provide an overview of the structure and function of the epidermis, dermis, and hypodermis, and showed in the recent research in skin regeneration, the main cells used, biomaterials studied that provide initial support for these cells, allowing the growth and formation of the neotissue and general characteristics, advantages and disadvantages of each methodology and the landmarks in recent research in the 3D skin bioprinting. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Baseline Raman Spectral Fingerprints of Zebrafish Embryos and Larvae.

Author

Abreu, Isabel Oliveira, Teixeira, Cláudia, Vilarinho, Rui, Rocha, A. Cristina S., Moreira, Joaquim Agostinho, Oliva-Teles, Luís, Guimarães, Laura, and Carvalho, António Paulo

Subjects
CHEMICAL fingerprinting, ESSENTIAL amino acids, RAMAN spectroscopy, DISCRIMINANT analysis, NUCLEIC acids
Abstract

As a highly sensitive vibrational technique, Raman spectroscopy (RS) can provide valuable chemical and molecular data useful to characterise animal cell types, tissues and organs. As a label-free, rapid detection method, RS has been considered a valuable asset in forensics, biology and medicine. The technique has been applied to zebrafish for various purposes, including physiological, biochemical or bioaccumulation analyses. The available data point out its potential for the early diagnosis of detrimental effects elicited by toxicant exposure. Nevertheless, no baseline spectra are available for zebrafish embryos and larvae that could allow for suitable planning of toxicological assessments, comparison with toxicant-elicited spectra or mechanistic understanding of biochemical and physiological responses to the exposures. With this in mind, this work carried out a baseline characterisation of Raman spectra of zebrafish embryos and larvae throughout early development. Raman spectra were recorded from the iris, forebrain, melanocytes, heart, muscle and swim bladder between 24 and 168 h post-fertilisation. A chemometrics approach, based on partial least-squares discriminant analysis (PLS-DA), was used to obtain a Raman characterisation of each tissue or organ. In total, 117 Raman bands were identified, of which 24 were well represented and, thus, retained in the data analysed. Only three bands were found to be common to all organs and tissues. The PLS-DA provided a tentative Raman spectral fingerprint typical of each tissue or organ, reflecting the ongoing developmental dynamics. The bands showed frequencies previously assigned to collagen, cholesterol, various essential amino acids, carbohydrates and nucleic acids. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Embryotoxicity and Molecular Alterations of Fluoxetine and Norfluoxetine in Early Zebrafish Larvae

Author

Rodrigues, Pedro, Cunha, V., Ferreira, M., Guimarães, Laura, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Amer, Mourad, Series Editor, Naddeo, Vincenzo, editor, Balakrishnan, Malini, editor, and Choo, Kwang-Ho, editor

Published
2020
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17. Performance of Electro-Fenton Water Treatment Technology in Decreasing Zebrafish Embryotoxicity Elicited by a Mixture of Organic Contaminants

Author

Amorim, João, Pinheiro, Carlos, Abreu, Isabel, Rodrigues, Pedro, Sanromán, M. Ángeles, Rosales, Emílio, Pazos, Marta, Soares, António, Delerue-Matos, Cristina, Saraiva, Aurélia, Oliva-Teles, Luís, Carvalho, António Paulo, Guimarães, Laura, Pisello, Anna Laura, Editorial Board Member, Hawkes, Dean, Editorial Board Member, Bougdah, Hocine, Editorial Board Member, Rosso, Federica, Editorial Board Member, Abdalla, Hassan, Editorial Board Member, Boemi, Sofia-Natalia, Editorial Board Member, Mohareb, Nabil, Editorial Board Member, Mesbah Elkaffas, Saleh, Editorial Board Member, Bozonnet, Emmanuel, Editorial Board Member, Pignatta, Gloria, Editorial Board Member, Mahgoub, Yasser, Editorial Board Member, De Bonis, Luciano, Editorial Board Member, Kostopoulou, Stella, Editorial Board Member, Pradhan, Biswajeet, Editorial Board Member, Abdul Mannan, Md., Editorial Board Member, Alalouch, Chaham, Editorial Board Member, O. Gawad, Iman, Editorial Board Member, Amer, Mourad, Series Editor, Naddeo, Vincenzo, editor, Balakrishnan, Malini, editor, and Choo, Kwang-Ho, editor

Published
2020
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18. As estimativas dos efeitos benéficos no uso do inibidor do cotransportador Sódio-Glicose 2 (iSGLT-2) na insuficiência cardíaca com fração de ejeção reduzida

Author

Dourado, Ageu Nunes, primary, Jesus, Maria Eduarda de, additional, Ribeiro, Jhonatan Picinin, additional, Guimarães, Luiz Cláudio Kehdi, additional, Bagnara, Vitoria, additional, Freitas, Sarah Cristina Gonçalves de, additional, Pedreira, Caio Kolozsvari, additional, Maia, Amanda Nunes da Cunha, additional, Kettenhuber, Louise Ilma, additional, Silva, Nubia Ferreira de Andrade, additional, Guerra, Maria Luísa Perosa, additional, Novaes, Bianca Amai Furucho, additional, Bertoni, Maria Fernanda Serafini, additional, Guimarães, Laura Gomes da Silva de Medeiros, additional, and Silva, Caroline Flores Bordon, additional

Published
2024
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20. FUNDAMENTOS E PRÁTICAS PEDIÁTRICAS E NEONATAIS

Author

Rafael, Ana Luísa Bonfim, primary, Pontes, Nayanne Hardy Lima, additional, Chaves, Melissa Magalhães Rodrigues, additional, Ferreira, Nathalya Menezes de Menezes, additional, Martins, Juliana Bezerra, additional, Landim, Sâmia Marques Lourenço, additional, Vasconcelos, Izabella Tamira Galdino Farias, additional, SILVA, MARIANA PEREIRA BARBOSA, additional, Loures, Leandro Luiz da Silva, additional, Moura, Layanne Cavalcante de, additional, Santos, Jéssika Roberta Firme de Moura, additional, Fonseca, Natana Maranhão Noleto da, additional, Fonseca, Vanessa Maranhão Noleto da, additional, Santos, Beatriz Sousa, additional, Moura, Viviane Silva de, additional, Gomes, Yulle Morais, additional, Apolinário, Joelma Maria dos Santos da Silva, additional, Ferreira, Barbara Rodrigues, additional, Dias, Nathália M, additional, Sousa, Samilly Lorâna Farias de, additional, Rocha, Samara Atanielly, additional, Bastos, Melissa Cavalcante, additional, Sousa, Maria do Livramento Siqueira, additional, Silva, Manoel Leonardo Tavares da, additional, Nascimento, Cidianna Emanuelly Melo do, additional, Souza, Vitória Caroline dos Santos de, additional, Souta, Elaine Soares, additional, Lopes, Layane Sampaio, additional, Lobato, Merivalda Vasconcelos, additional, Santos, Mirlena Letícia Souza dos, additional, Sanches, Raiane Pereira, additional, Morais, Raquel Pereira, additional, Vieira, Rosiene Rodrigues, additional, Almeida, Silmara Nayra Silva, additional, Silva, Thais de Melo da, additional, Souza, Vitória Caroline dos Santos, additional, Dias, Nathália Menezes, additional, Ferreira, Nathálya M de M, additional, Rafael, Ana Luisa B, additional, Martins, Juliana B, additional, Chaves, Melissa M R, additional, Vasconcelos, Izabella Tamira G F, additional, Feitosa, Maria Clara Duarte, additional, Nunes, Camila da Silva Lopes, additional, Viana, Carine Cristina Oliveira, additional, Santos, Zaira Antônia Sousa Dos, additional, Frota, Maria Madalena Cardoso Da, additional, Silva, Letícia Alves Rodrigues, additional, Torres, Samir Da Rocha Fernandes, additional, Rocha, Maria Izabel Felix, additional, Barros, Ingrid Cristina Rêgo, additional, Barros, Cassandra M A R, additional, Almeida, Joelson dos Santos, additional, Desto, Nádia Beatriz, additional, Santos, Teresa Cristina Maia dos, additional, Borges, Bruna da Cruz Beyruth, additional, Silva, Ana Flávia Lima, additional, Cardoso, Gabriela Alexandra Amaral, additional, Leal, Gabriely do Nascimento, additional, Raposo, Júlia Cordeiro Brandão, additional, Borges, Lara Freitas, additional, Ferreira, Rayne Curto do Nascimento, additional, Machado, Renata Leão, additional, Barros, Thiago Botelho de, additional, Couto, Amanda Vieira, additional, Saldanha, Janaína Cláudia da Silva, additional, Aguiar, Alessandra N de, additional, Lopes, Ana Luísa Junho, additional, Tsutsumi, Ariane Abreu, additional, Mendes, Emanuelle Xavier Martins, additional, Ferreira, Karina Fernandes Ruiz, additional, Castro, Pedro Keese de, additional, Marco, Valentina Maria Fernandes de, additional, Menezes, João Daniel de Souza, additional, Rosário, Jéssica Reis Do, additional, Alves, Nágila Silva, additional, Soares, Rosana Maria Nogueira Gonçalves, additional, Gonçalves, Fernanda de Sousa, additional, Oliveira, Luinê Ferreira de, additional, Silva, Aline Alves da, additional, Homem, Dayla Soeiro, additional, Silva, Keulle Mayara Barros do Nascimento, additional, Oliveira, Naynne Fernanda Galvão de, additional, Silva, Emylla De Sousa, additional, Oliveira, Brian Araujo, additional, Cunha, Victória da Silva da, additional, Leandro, Andressa Muniz, additional, Alves, Adriely Martins da Conceição, additional, Almeida, Rayane Oliveira, additional, Carneiro, Ana Luiza, additional, Faria, Kathleen Emerick Paiva, additional, Lima, Aleksander Luís, additional, Silva, Bruna Gonçalves da, additional, Soares, Carolina Rocha, additional, Costa, Cynthya Magalhães, additional, Miareli, Felipe, additional, Moscardini, Ighor Monteiro, additional, Carvalho, Isadora Saddi de, additional, Pastro, João Félix de Mattos, additional, Bueno, João Victor de Moraes, additional, Vieira, Júlia Marques, additional, Costa, Letícia, additional, Meira, Melissa Andrade, additional, Guimarães, Rodrigo Quinte, additional, Matos, Romulo Vasconcellos Ribeiro, additional, Alves, Allana Victória Pereira, additional, Cavalcante, Alícia Tenório, additional, Fechine, Amanda Macêdo, additional, Almeida, Ana Beatriz Dantas de, additional, Cruz, Elizabeth Fechine, additional, Rocha, Fernanda Sampaio Feitosa, additional, Silva, Islânia Pacheco da, additional, Macedo, Julia Tenório Lossio de, additional, Lima, Laura de Souza, additional, Pereira, Maria Eduarda Coutinho da Franca, additional, Matias, Maria Inês de Araújo Sousa, additional, Roque, Maria Luiza Teixeira de Carvalho, additional, Moraes, Sabryna Meira Carvalho de, additional, Pereira, Sibely Coelho Urbano, additional, Santos, Taynara Souza, additional, Said, Beatriz Rigoli, additional, Abreu, Barbara Seffair de Castro de, additional, Moraes, Bruna Maria Pedrosa, additional, Leão, Nayara Paloma Carvalho de Oliveira, additional, Paiva, Maria Noel Rigoli, additional, Pereira, Andrea Ferreira, additional, Santos, Francy Hadarssa Albuquerque dos, additional, Resende, Giovanna Medeiros, additional, Lima, Gyovanna Braz Porto de Queiroz Ribeiro, additional, Campos, Joanny Elizabeth Maria Pimentel, additional, Lima, Leticia Britto Gama de, additional, Jesus, Maisa Mendonça de, additional, Teixeira, Maria Eduarda Montenegro Damaso, additional, Maciel, Maria Izadora Sena, additional, Lima, Letícia Britto Gama de, additional, Jesus, Maísa Mendonça de, additional, Vilefort, Laís Assunção, additional, Lopes, Amanda Brandão, additional, Vidal, Laura de Oliveira Veloso, additional, Pereira, Sofia Lúcia El Hauche, additional, Campos, Isadora Assunção Vaz Porto, additional, Lobato, Júlia Lacerda, additional, Silva, Isadora Faria, additional, Campos, Laura Assunção Vaz Porto, additional, Pinto, Letícia Maria Barbosa, additional, Silva, Juliana Cardoso da, additional, Oliveira, Bianca Veloso Vidal de, additional, Oliveira, Juliana Karine de, additional, Brito, Warlon Jorge, additional, Silva, Rachel Macêdo Souza Pedro da, additional, Jardim, Paula Fulgêncio Tanure, additional, França, Gabriel Eugênio Esteves Rocha, additional, Nunes, Beatriz Carnevalli, additional, Lobato, Gustavo de Freitas, additional, Oliveira, Andressa Pâmela de, additional, Costa, Rayssa Mara Ferreira, additional, Gonçalves, Ana Luiza Lima, additional, Pereira, André Luís Campos Louredo, additional, Sabino, Izadora Marina de Oliveira, additional, Ribeiro, Ayla Silva Sygilião, additional, Gomes, João Adriel Rodrigues, additional, Cardoso, Bruna do Nascimento, additional, Magalhães, Felipe Pueyo, additional, Figueiredo, Anna Luísa Rodrigues Soares Silva, additional, Oliveira, Julia de Paula, additional, silva, Haroldo Souza e, additional, Pinto, Andressa Leodorico, additional, Frade, Laura Vitória de Oliveira, additional, Vieira, Júlia Diniz Marra, additional, Viana, Maria Elisa Latini, additional, Cunha, Jorge Romel, additional, Guedes, Mayco Oliveira, additional, Pinheiro, Fernanda Dias, additional, Silveira, Rachel Pimentel Romano, additional, Trindade, Ana Vivian de Miranda, additional, Martins, Marinna Avatar, additional, andrade, Lorenzo brezinski bellinazzi de, additional, Faria, Moisés Lopes Cançado de, additional, Guimarães, Camila Campos Avelar, additional, Nunes, Patricia Pimenta, additional, Carmo, Leticia Saad do, additional, Magalhães, Pedro Antônio Ribeiro Dayrell, additional, Leal, Ana Luiza Alvim, additional, Guedes, Denis da Silva, additional, Souza, Clara Martins Resende de, additional, Possa, Dalila Percilia Siqueira, additional, Cerbarro, Gabrielle Fernanda, additional, Costa, João Pedro Souza Ferreira, additional, Oliveira, Bárbara Martins Mello de, additional, Oliveira, Dara Campos de, additional, Costa, Henrique Brandião, additional, Magalhães, Ícaro Silva, additional, Silva, Ingrid Duarte da, additional, Costa, Ivy Letícia Brandião, additional, Martins, Mariah Prado, additional, Lisboa, Victória Sardinha de, additional, Cacau, Leandro Gervasio Antunes, additional, Oliveira, Victória Martins Mello de, additional, Rocha, Anderson de Almeida, additional, Junqueira, Camila Fonseca Silva, additional, Andrade, Kayan Felipe de Oliveira, additional, Gomes, Matheus Esquerdo, additional, Parma, Isabela Teixeira, additional, Souza, Gustavo Meirelles, additional, Freguglia, Philippe Guedes, additional, Melo, Júlia Carvalho de, additional, Antunes, Victor Rocha Moreira, additional, Soares, Pedro Veiga de Paula, additional, Pompei, Vinícius Abritta, additional, Junqueira, Laís Silveira, additional, Delphino, Anna Laura Lima, additional, Oliveira, Luciano José Fontes de, additional, Oliveira, Lucas Avinner Afonso de, additional, Ferreira, Nathalia de Araújo, additional, Pires, Victoria Cristina Lodron, additional, Pereira, Luis Fernando Mendes, additional, Pires, Paulo Henrique Lobato, additional, mesquita, Gabriel Albuquerque, additional, Vieira, João Pedro Santana, additional, Almeida, Beatriz Martins Guerra Pantuza, additional, Avelar, João Victor de Miranda, additional, Brandão, Renata Alvares, additional, Morais, Mariana Melo de, additional, Barbosa, Mário Henrique Araújo, additional, Oliveira, Fernanda Silva de, additional, Siqueira, Ana Luiza Faria e, additional, Fonseca, Camilla Gonçalves Corradi, additional, Barcelos, Rafaella Viana Ferreira, additional, Pouza, Matheus Henrique Campos, additional, Coutinho, Thais Dias, additional, Fiorilo, Luciana Calderano, additional, Sidrim, Gustavo Henrique Silva, additional, Santos, Camila Aparecida Campos, additional, Neves, Flavia Bedeti, additional, Pimenta, Aline Vilela, additional, Jabour, Matheus Silva Cordeiro, additional, Barreto, João Murta, additional, Barreto, Pedro Murta, additional, Hostt, Luísa Pettz Oliveira, additional, Ferreira, Tulio Coura Moreira dos Santos, additional, Vieira, Pedro Henrique Gomes, additional, Graça, Gabriela Arantes da Cunha, additional, Alves, Vinícius Tadeu Silveira, additional, Goulart, Jéssica, additional, Parisi, Mariana Migliorini, additional, Cattaneo, Roberta, additional, Martins, Rebeca da Gama Cerqueira Ferraz, additional, Rachid, Marina de Moura, additional, Santana, Mariana Briglia de, additional, Rachid, Clara de Moura, additional, Santos, Emília Oliveira, additional, Mendonça, Larissa Lima Pessoa de, additional, Nascimento, Isabella Lima, additional, Sapori, Angélica Navarro, additional, Moraes, Liliane Regina de Souza, additional, Costa, Danielle Lima da, additional, Pissolatto, Gabrielle Grecov, additional, Carvalho, Marianne Rocha Duarte de, additional, Rocha, Silvana Santiago da, additional, Sales, Isabela Maria Magalhães, additional, Figueiredo, Emmanoel Martins, additional, Araújo, Vitória Jannyne Guimarães de Sousa, additional, Sales, Pedro Henrique Barbosa, additional, Ferrer, Iago Araújo, additional, Marinho, Denis Pontes, additional, Lima, Marcos Roberto de Oliveira, additional, Bezerra, Maria Victoria Hiluy Habibe, additional, Mota, Antônio Alberto Bastos, additional, Vidal, Brayon Freire Blanquett, additional, Cavalcante, Ana Carolina Pinheiro Frota, additional, Paula, Rebeka Ventura Pessôa de, additional, Aguiar, Aryane Cruz, additional, Sampaio, Rafaela Montenegro Aires, additional, Holanda, Abner Pedrosa, additional, Rodrigues, Marina Machado, additional, Lisboa, Débora D'Agostini Jorge, additional, Amarante, Michael Vieira do, additional, Rezende, Ana Cristina Arruda, additional, Rabelo, Ana Luiza Andrade, additional, Oliveira, Bianca Nascimento, additional, Batista, Fernanda Ribeiro Gonçalves Bolina, additional, Passos, Giovana Lemos, additional, Souza, Ingra Kozlovwsky, additional, Barros, Isabella de Caux Saez Bragança, additional, Lima, Lavínia Nobre Moraes, additional, Costa, Mariana Isabel Alvim, additional, Nadais, Giovana Lopes, additional, LUSTOSA, CARLA RODRIGUES, additional, Freitas, Gabriela Moura, additional, Oliveira, Juliana Barros Vianna de, additional, CARDOSO, LUÍSA RODRIGUES, additional, Leal, Miriam Martins, additional, Pereira, Ana Luíza Oliveira, additional, Porto, Anna Clara Colen, additional, Carvalho, Anna Luiza Homan Araújo, additional, Melo, Bruna Portela Costa Ferreira de, additional, Teatini, Clarissa Moreira, additional, Souza, Helanny Dutra de, additional, Melo, Arthur Lira de, additional, Andrade, Camilla Katarine Delgado, additional, Sobral, Ellen Beatriz, additional, Santos, Isabelle Thaís da Silva, additional, Macedo, João Victor Tenório Lossio de, additional, Menezes, Marcelo Diniz de, additional, Gomes, Maria Clara Cirilo, additional, Matias, Maria Eduarda Borges, additional, Ferreira, Maria Eduarda Rodrigues, additional, Ramos, Mônica Moura, additional, Oliveira, Osman Lucena Félix de, additional, Moreira, Cibely Souza Ribeiro, additional, Madeira, Fernanda Orlando Pompeu, additional, Gaia, Gabriel Gontijo Guimarães, additional, Wulf, Isabela Gondim, additional, Feijóo, Isabella Cheremetta, additional, Anacleto, José Hyde Augusto Zschaber, additional, Cabral, Julia Alice Borges, additional, Caetano, Juliana Dias Moreira, additional, Araújo, Juliana Maria Mendes de, additional, Pereira, Lêda Mendes, additional, Sousa, Virgínia Araújo de, additional, Lage, Yasmin Souza, additional, Uggioni, Natália Custódio, additional, Zanatta, Luiza Mazzucco, additional, Santos, Gabriela Nuernberg dos, additional, Tonial, Julia Sgarbossa, additional, Reichert, Júlia Turra, additional, Bazotti, Lara Xavier, additional, Duarte, Gabriela Ugioni, additional, Teixeira, Letícia Maffioletti, additional, Dalponte, Letícia de Stefani, additional, Teixeira, Maria Julia Lindermann Peressoni, additional, Colombo, Cecília Colonetti, additional, Santos, Ana Carolina Bezerra Chagas, additional, Teixeira, Beatriz Sotéro Oliveira, additional, Sales, Renata Vitoria de Fraça, additional, Guimarães, Laura Amédée Péret, additional, Vieira, Lara Silveira, additional, Pena, Lavínia Vasconcellos Patrus, additional, Nepomuceno, Lara Reggiani, additional, Moreira, Luiz Felipe Guimarães Gualberto, additional, Rangel, Laura Kapp, additional, Ramalho, Lívia Corrêa, additional, Queiroz, Isabella Timbó, additional, Andrade, Maria Denise Fernandes Carvalho de, additional, Carvalho, Ellaine Dóris Fernandes, additional, Paiva, Viviane Nogueira de, additional, Rocha, Nadiny Francis Silveira, additional, Souza, Maria Carolina Sticanele de, additional, Vieira, Nelmara Alvarenga, additional, Lages, Laryssa Guimarães, additional, Mata, Luísa Oliveira Santos Da, additional, Lembrance, Lara Macedo, additional, Roque, Natália Lages, additional, Faria, Ana Luísa Braga Abalen, additional, Maia, Maria Eduarda De Lima, additional, Fernandes, Thiago Barbosa, additional, Mendonça, Stephany Brini de, additional, Duarte, Melissa Nadal, additional, PESSANHA, DAYANE JARDIM, additional, Marques, Larissa de Oliverira Cassini, additional, Pereira, Laura Costa, additional, Camargo, Anna Cláudia Domínguez Alves Bohn de, additional, Carvalho, Luma Alves Fonseca, additional, Fujimoto, Ruth Helena Pimenta, additional, Cordeiro, Aline Araújo, additional, Carvalho, Victoria Cristina de Jesus, additional, Lima, Vitória Emily Amorim, additional, Cabral, Luana Guimarães Lima, additional, Cavalcanti, Amanda Vanessa Bandeira de Araújo, additional, Fireman, Gabriela Holanda Carvalho, additional, Lima, Maria Carolina Oliveira, additional, Farias, Vandriely Marie de Albuquerque, additional, Oliveira, Letícia Brandão Barbosa de, additional, Ferreira, Maria Eduarda Rech, additional, Sirqueira, Sarah Valões Tenorio, additional, Cardoso, Paula Thaís Sousa de Oliveira, additional, Cavalcanti, Isabela de Farias, additional, Monteiro, Marcos Brunno Aguiar, additional, Perezini, Renato de Paula, additional, Costa, Víctor de Oliveira, additional, Rosa, Marlon José dos Santos, additional, Lima, Hugo Tomé de Souza, additional, Freitas, Pedro Carvalho, additional, Adriano, Ana Paula dos Santos, additional, Pereira, Maria Eduarda Ribeiro Coutinho da Franca, additional, Nunes, Beatriz Carnevalli Motta, additional, Costa, João Lucas Santiago Angelos, additional, Rocha, Raphael Alves, additional, Goulart, Jessica dos Santos, additional, and Siqueira, Maria Luiza Andrade, additional

Published
2021
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21. IMUNOTERAPIA NA DOENÇA DE HUNTINGTON: UMA REVISÃO SISTEMÁTIC

Author

Martin, Rafael Ribeiro Hernandez, primary, Gontijo, Bruna de Alcântara Veloso, additional, Guimarães, Joyce de Souza, additional, Toledo, Rafaela Germano, additional, Patricio, Bárbara Morando Kalil, additional, Verde, Liz de Albuquerque Lessa Villa, additional, Mesquita, Harleson Lopes de, additional, Sousa, Amanda Leite, additional, and Guimarães, Laura Cardoso, additional

Published
2021
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24. Theoretical Exploration of the Antioxidant Activity, Chemopreventive, and Antineoplastic Potentials of Molecules Present in Morinda lucida, Momordica charantia, and Vernonanthura polyanthes.

Author

de Aguiar, Antônio Sérgio Nakao, da Costa Rodrigues, Lara Lorhany Gomes, Rocha, Jamira Dias, Guimarães, Laura Maria Marques, Ramos, Laysse Cristina Cândida, Napolitano, Hamilton Barbosa, Bailão, Elisa Flávia Luiz Cardoso, and Borges, Leonardo Luiz

Subjects
MOMORDICA charantia, VASCULAR endothelial growth factor receptors, ESTROGEN receptors, ABSTRACTION reactions, MOLECULES
Abstract

Cancer is one of the leading causes of death worldwide and one of the top four causes of premature death in most countries. Several studies have shown that secondary metabolites found in medicinal plants have anticancer, antimutagenic, anti-genotoxic, and chemopreventive effects. Ethnobotany knowledge points to Morinda lucida, Momordica charantia, and Vernonanthura polyanthes as anticancer plants, turning them into promising candidates for cancer treatment. This study analyzed M. lucida, M. charantia, and V. polyanthes compounds to identify potential antioxidant, chemopreventive, and anticancer agents through in silico analysis. We performed pharmacokinetics, biological activities, and toxicological predictions besides molecular docking. Theoretical calculations on thermodynamic grounds of the antioxidant properties were determined using density functional theory. The molecules damnacanthal, momordicin I, and quercetin-3- O -rutinoside identified in M. lucida, M. charantia, and V. polyanthes, respectively, presented good anticancer potential and were chosen for the molecular docking study and DFT calculations. According to Lipinski's criteria, damnacanthal, momordicin I, and quercetin-3- O -rutinoside were classified as potential drugs, especially for the pharmacokinetics criteria. Damnacanthal and momordicin I had high absorption in the gastrointestinal treatment, while quercetin-3- O -rutinoside had low absorption. These compounds also demonstrated antineoplastic, antimutagenic, and cancer-preventive activity, according to the in silico analysis. In this sense, damnacanthal, momordicin I, and quercetin-3- O -rutinoside were chosen to test their potential interactions with the beta estrogen receptor, vascular endothelial growth factor receptor 2, and xanthine dehydrogenase, respectively, and intermolecular interactions were determined. Regarding the antioxidant potential of the structures, two different mechanisms were scrutinized with the help of their respective molecular descriptors, such as hydrogen atom transfer (HAT) and one-electron transfer (ET). In conclusion, this computational study revealed that damnacanthal, momordicin I, and quercetin-3- O − rutinoside are promising chemoprotective and anticancer molecules with favorable pharmacokinetics and toxicological properties. The compounds damnacanthal, momordicin I, and quercetin-3-O-rutinoside in the species studied have a potential chemopreventive; In silico models allow the relationship between previous results of this herbal species and the chemical markers analyzed; DFT calculations support the antioxidant mechanisms of the Chemical markers studied; [ABSTRACT FROM AUTHOR]

Published
2024
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27. Epidemiologia e Políticas Públicas de Saúde - Volume 2

Author

Rodrigues, Antonio Bruno do Nascimento, primary, Uchôa, Lucas R, additional, Soares, Thalia M de S, additional, Guimarães, Kayra C, additional, Brandão, Fabricio de Sousa, additional, Lopes, Samara Raquel dos Santos, additional, Almeida, Caroline R de, additional, Silva, Ana Paula Pereira da, additional, Ananias, Lucas, additional, Medeiros, Adam Kelsom Gomes, additional, Santos, José M da S, additional, Amaral, Jéssica Sabrinne Araújo, additional, Silva, Ana Maria Ferreira da, additional, Trindade, Ana Paula Santos, additional, Nascimento, José Italo Silva, additional, Carmo, Laiza de Oliveira do, additional, Santos, Almir Orsano dos, additional, Lazzarotto, Eliana Maria, additional, Momentti, Ana Carolina, additional, Tajra, Fábio Solon, additional, Mendes, Breno Coelho, additional, Aguiar, Bruno Guedes Alcoforado, additional, Costa, Dorcas Lamounier, additional, Batista, Francisca Miriane de Araújo, additional, Silva, Rodrigo Aragão da, additional, Alfredo, Julia Perito, additional, Bigolin, Laura de Lima, additional, Warlet, Luiza Biondi, additional, Alfredo, Camila Perito, additional, Lerro, Lucas, additional, Lerro, Leonardo, additional, Netto, Lana Ferreira Porto Coelho, additional, Moura, Gabriela Vasconcelos de, additional, Suleiman, Nariman Mohamad Abdel Salam, additional, Nobre, Rony Kafer, additional, Carvalho, Kaique Maximo de Oliveira, additional, Gois, Pollyana dos Santos, additional, Santana, Vitória Santos de, additional, Andrade, Ana Paula de Oliveira, additional, Sacramento, Gielson Almeida do, additional, Oliveira, Priscila Mendes Grana, additional, Lira, Kaline Vitória Lima, additional, Rocha, Álvaro Sepúlveda Carvalho, additional, Rocha, Antônio Carlos Guilherme, additional, Santos, Emanuelle Cristine Alves dos, additional, Sousa, José Samuel Teixeira de, additional, Santos, Natália Carvalho de Sousa, additional, Araújo, Telma Maria Evangelista de, additional, Nunes, Karen Lainy dos Reis, additional, Silva, Suzana Fernandes da, additional, Nascimento, Sara Lúcia Portela do, additional, Rocha, Nataly Ramos, additional, Lima, Vitória Assis, additional, Maia, Elayne Silva, additional, Lima, Kaio Filipe Nunes, additional, Cardoso, Thalita Boanerges Miranda, additional, Gonçalves, Lícia de Sousa, additional, Bastos, Larissa do SS, additional, Ferreira, Lucas A, additional, Lima, Alex Ranieri Jerônimo, additional, Moraes, Leonardo Gomes Cavalieri de, additional, Ribeiro, Thaís de Menezes, additional, Amorim, Lidiane Lindinalva Barbosa, additional, Oliveira, Caio alves de, additional, Monteiro, Rayane M M, additional, Santos, Edson Peres dos, additional, Soares, Thalia Maria de Sousa, additional, Galvão, Rubens Francisco Pereira, additional, Amorim, Liliane Barbosa, additional, Santos, Antonio Robson Dos, additional, Vieira, Cleyson Pereira Castro, additional, Borges, Gustavo de Oliveira, additional, Freitas, João Luis Galvão, additional, Ferreira, João Lucas Pereira, additional, Lopes, Lucas Costa, additional, Barros, Yago de Oliveira, additional, Montes, Nadja Janayra Morais, additional, Delcole, Giovanna, additional, Pinto, Natália de Santana, additional, Oliveira, Otávio Augusto Barbosa de, additional, Rodrigues, Rodrigo Ferreira, additional, Toledo, Rodrigo Ruas Floriano de, additional, Moreira, Lyslian J A, additional, Oliveira, Elaine Eugênio de, additional, Addor, Nicolas, additional, Diaz, Melissa, additional, Fernandes, Márcia A, additional, Brito, Cleidiane Maria Sales de, additional, Santos, Gerarlene Ponte Guimarães, additional, Luz, Phellype Kayyaã da, additional, Brandão, Socorro Adriane de S Meneses, additional, Costa, Rayla Maria Pontes Guimarães, additional, Figueiredo, Maria do LF, additional, Gouveia, Márcia Tales de Oliveira, additional, Santos, João Gabriel Ribeiro dos, additional, Fernandes, Márcia Astrês, additional, Pillon, Sandra Cristina, additional, Ibiapina, Aline Rafael de Sousa, additional, Silva, Angela dos Santos, additional, Vieira, Ingrid Raquel Lima, additional, Passos, Bruna Victoria da Silva, additional, Oliveira, Douglas Vieira de, additional, Leite, Wellington Macêdo, additional, Lima, Diellison Layson dos Santos, additional, Ramsdorf, Maria Theresa de Alencar, additional, Yoshikawa, Catherine Alexia, additional, Menezes, João Gabriel da Silva, additional, Pereira, Luiz Fernando Benazet de Assunção, additional, Redígulo, Tayná Boldoni, additional, Queiroz, Ana Paula Dossi de Guimarães e, additional, Pedrão, Mariana D, additional, Axer, Mariana O, additional, Gonçalves, Joubert M, additional, Amaral, Letícia L M, additional, Oliveira, Lucas L, additional, Salgado, Lucas S, additional, Porto, Luiza L, additional, Morais, Maria Clara M, additional, Esteves, Raquel D, additional, Carvalho, Thiago L, additional, Soares, Vinícius C, additional, Bossi, Vinícius M, additional, Macedo, Natan L De, additional, Saurini, Thainá M, additional, Freitas, Victor H F, additional, Salgado, Camila S, additional, Costa, Marina Lua Vieira de Abreu, additional, Martins, Thaís Santos, additional, Silva, Fernando José Guedes da, additional, Sales, Jaqueline Carvalho e Silva, additional, Moura, Marcoeli Silva de, additional, Silva, Marla Ariana, additional, Bernini, Daiane Moreira Aguiar, additional, Bernini, Anderson Esteves, additional, Belo, Vinícius Silva, additional, Santos, Regina Consolação dos, additional, Pena, Heber Paulino, additional, Moraes, Juliano Teixeira, additional, Morici, Isabelle Assis, additional, Oliveira, Cíntia Gonçalves, additional, Vasconcelos, Deolane Eustáquia Antunes, additional, Lisboa, Cristiane Rabelo, additional, Diassis, Matheus Alexandre Bezerra, additional, Lima, Ana Victória Mota, additional, Araújo, Helenilda de Sousa, additional, Nobre, Beatriz Gomes, additional, Siqueira, Lucas Sampaio, additional, Pereira, Antonia Vitória Gomes, additional, Santos, Gleice Laisla de Oliveira, additional, Soares, Vitória da Silva, additional, Santos, Vivian Rafaela Almeida, additional, Costa, Natalya Wegila Felix da, additional, Meneses, Ian Alves, additional, Macêdo, Luiz Fernando Reis, additional, Forte, Gustavo Cabral, additional, Alencar, Gisely Torres de, additional, Remaili, Nadine Roiz, additional, Machado, Ana Carolina de Mesquita Netto, additional, Costa, Andressa Ribeiro da, additional, Adjuto, Clara Araújo, additional, Silva, Gabriel Antunes Sousa, additional, Couto, Karinny Guimarães, additional, Garavello, Maria Eugenia Mana, additional, Cardoso, Nicole Nogueira, additional, Nunes, Pedro Augusto Carrijo, additional, Carvalho, Sabrina Oliveira, additional, Abed, Yasser Nader, additional, Santos, Nycolle Santana dos, additional, BEZERRA, LEVI ARAUJO, additional, Vieira, Mikaelly Nunes, additional, Souza, Luiz Carlos Alves de, additional, Marques, Paula Ramalho, additional, Almeida, Adriana Jardim de, additional, Felix, Aline de Oliveira, additional, Pereira, Gabriela Martins, additional, Araujo, Giulia Del Giudice Figueiredo de, additional, Araujo, Lorena Costa, additional, Hyppolito, Rebeca Reginna da Costa, additional, Luz, Paulo Cesar de Moura, additional, Alcântara, Rafaella Silva, additional, Rodrigues, Priscylla Frazão, additional, Lins, Raphaela da Penha, additional, Silva, Tarcísio Rodrigues da, additional, Calheiros, Cláudia Maria Lins, additional, Sander, Renata Cury, additional, Luz, Risocelly dos Santos Andrade, additional, Andrade, Risolene dos Santos, additional, Brito, Mychelangela de Assis, additional, Rocha, Silvana Santiago da, additional, Costa, Ruth Silva Lima da, additional, França, João Vítor da Silva, additional, Conceição, Matilde da Silva, additional, Souza, Christopher Wando da Silva, additional, Ricardo, Nadab Santos, additional, Maia, Nathalia Oliveira Martins, additional, Araújo, Célio Clayson Souza de, additional, Silva, Aldemir Victor de Araújo, additional, Oliveira, Nathan Lima de, additional, Ramos, Sabrina Brito, additional, Ferreira, Luis Felipe da Silva, additional, Oliveira, Matheus Pedrosa De, additional, França, Nathalia Cristina Pereira De, additional, Souza, Thalis Ferreira De, additional, Rodrigues, Stefânia, additional, Luiz, Angel Renaro Ferreira, additional, Moreira, Carla, additional, Lima, Dirce Marisa Lopes de, additional, Oliveira, Vitória de, additional, Souza, Tiago Antonio de, additional, Asìn, Paola Isabel Carrasco, additional, Gerheim, Ester Gomes, additional, Leite, Isabel Cristina Gonçalves, additional, Ribeiro, Luiz C, additional, Scheibe, Victória Machado, additional, Zanatta, Stefanie Flach, additional, Krug, Bruna Reis, additional, Leon, Cristiano De, additional, Cruz, Ludimila Ferreira Sousa, additional, Medeiros, Monayra Amaral, additional, Romanielo, Ana Flávia Resende, additional, Garbelini, Giulia Ugucioni, additional, Antonelli, Laíne Ribeiro, additional, Borges, Daniel Martins, additional, Guimarães, Laura Alves, additional, and Sabino, Barbara Correia Neves, additional

Published
2020
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35. Performance of Electro-Fenton Water Treatment Technology in Decreasing Zebrafish Embryotoxicity Elicited by a Mixture of Organic Contaminants

Author

Amorim, João, primary, Pinheiro, Carlos, additional, Abreu, Isabel, additional, Rodrigues, Pedro, additional, Sanromán, M. Ángeles, additional, Rosales, Emílio, additional, Pazos, Marta, additional, Soares, António, additional, Delerue-Matos, Cristina, additional, Saraiva, Aurélia, additional, Oliva-Teles, Luís, additional, Carvalho, António Paulo, additional, and Guimarães, Laura, additional

Published
2019
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43. Sensitivity of Triops longicaudatus Locomotor Behaviour to Detect Short Low-Level Exposure to Pollutants.

Author

Guimarães, Laura, Carvalho, António Paulo, Ribeiro, Pedro, Teixeira, Cláudia, Silva, Nuno, Pereira, André, Amorim, João, and Oliva-Teles, Luís

Subjects
POLLUTANTS, ARTIFICIAL neural networks, MERCURY poisoning, ENVIRONMENTAL quality, ENVIRONMENTAL health, SODIUM hypochlorite, MEDITERRANEAN climate, FORMALDEHYDE
Abstract

Triops longicaudatus is a crustacean typically inhabiting temporary freshwater bodies in regions with a Mediterranean climate. These crustaceans are easily maintained in the laboratory and show a set of biological features that make them good candidates for diagnosing environmental quality and health. However, information about their responses to environmental contamination is scarce. This study characterised the locomotor responses of juvenile and adult/mature T. longicaudatus to low concentrations of five model toxicants upon a very short 1.5 h exposure: tributyltin, mercury, lindane, sodium hypochlorite and formaldehyde. A video-tracking system was used to record the locomotor behaviour. The data were analysed with an artificial neural network to identify distinct behaviours, followed by Chi-square and Correspondence analysis to characterise the response to each toxicant. The results showed that T. longicaudatus is sensitive to aquatic contamination, particularly sodium hypochlorite. Six behaviour types were defined, which allowed for the characterisation and discrimination of the test toxicants. The results support the need for more investigation into this species and its behaviour types as an alternative to animal testing and the more apical and often invasive endpoints commonly recommended in standard guidelines. [ABSTRACT FROM AUTHOR]

Published
2024
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48. Cytotoxicity and maternal toxicity attributed to exposure to Momordica charantia L. (Cucurbitaceae) dry leaf extract

Author

Trautenmuller, Ana Luisa, primary, de Almeida Soares, Jonathan, additional, Behm, Kamila Campos, additional, Guimarães, Laura Maria Marques, additional, Xavier-Silva, Kássia Roberta, additional, Monteiro de Melo, Anielly, additional, Caixeta, Graziele Alícia Batista, additional, Abadia Marciano de Paula, Joelma, additional, Luiz Cardoso Bailão, Elisa Flávia, additional, and Amaral, Vanessa Cristiane Santana, additional

Published
2022
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