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167 results on '"Guillaume, V"'

10. High pathogenicity of wild-type measles virus infection in CD150 (SLAM) transgenic mice

Author

Sellin, Ci, Davoust, N., Guillaume, V., Baas, D., Belin, Mf, Buckland, R., Wild, Tf, Horvat, B., and Deleage, Gilbert

Subjects
[SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology
Abstract

Measles virus (MV) infection causes an acute childhood disease, associated in certain cases with infection of the central nervous system and development of a severe neurological disease. We have generated transgenic mice ubiquitously expressing the human protein SLAM (signaling lymphocytic activation molecule), or CD150, recently identified as an MV receptor. In contrast to all other MV receptor transgenic models described so far, in these mice infection with wild-type MV strains is highly pathogenic. Intranasal infection of SLAM transgenic suckling mice leads to MV spread to different organs and the development of an acute neurological syndrome, characterized by lethargy, seizures, ataxia, weight loss, and death within 3 weeks. In addition, in this model, vaccine and wild-type MV strains can be distinguished by virulence. Furthermore, intracranial MV infection of adult transgenic mice generates a subclinical infection associated with a high titer of MV-specific antibodies in the serum. Finally, to analyze new antimeasles therapeutic approaches, we created a recombinant soluble form of SLAM and demonstrated its important antiviral activity both in vitro and in vivo. Taken together, our results show the high susceptibility of SLAM transgenic mice to MV-induced neurological disease and open new perspectives for the analysis of the implication of SLAM in the neuropathogenicity of other morbilliviruses, which also use this molecule as a receptor. Moreover, this transgenic model, in allowing a simple readout of the efficacy of an antiviral treatment, provides unique experimental means to test novel anti-MV preventive and therapeutic strategies.Measles virus (MV) infection causes an acute childhood disease, associated in certain cases with infection of the central nervous system and development of a severe neurological disease. We have generated transgenic mice ubiquitously expressing the human protein SLAM (signaling lymphocytic activation molecule), or CD150, recently identified as an MV receptor. In contrast to all other MV receptor transgenic models described so far, in these mice infection with wild-type MV strains is highly pathogenic. Intranasal infection of SLAM transgenic suckling mice leads to MV spread to different organs and the development of an acute neurological syndrome, characterized by lethargy, seizures, ataxia, weight loss, and death within 3 weeks. In addition, in this model, vaccine and wild-type MV strains can be distinguished by virulence. Furthermore, intracranial MV infection of adult transgenic mice generates a subclinical infection associated with a high titer of MV-specific antibodies in the serum. Finally, to analyze new antimeasles therapeutic approaches, we created a recombinant soluble form of SLAM and demonstrated its important antiviral activity both in vitro and in vivo. Taken together, our results show the high susceptibility of SLAM transgenic mice to MV-induced neurological disease and open new perspectives for the analysis of the implication of SLAM in the neuropathogenicity of other morbilliviruses, which also use this molecule as a receptor. Moreover, this transgenic model, in allowing a simple readout of the efficacy of an antiviral treatment, provides unique experimental means to test novel anti-MV preventive and therapeutic strategies.

Published
2006

11. Role of endogenous somatostatin in the GH response to exogenous GHRH

Author

Mauro Cataldi, Magnan, E., Guillaume, V., Mazzocchi, L., Dutour, A., Conte-Devolx, B., Oliver, C., Cataldi, Mauro, Magnan, E., Guillaume, V., Mazzocchi, L., Dutour, A., Conte Devolx, B., and Oliver, C.

Subjects
Somatostatin, GH, portal blood
Abstract

A study performed in awake rams undergoing hypophysial portal blood sampling to assess the changes in SRIF occurring upon GHRH acute administration

Published
1994

12. Excitatory amino acids and adenopituitary hormone secretion in mammals, with special reference to development

Author

Oliver, C., Boudouresque, F., Chautard, T., Jezová, D., Denis Becquet, Guillaume, V., Héry, F., Giraud, P., Grino, M., Becquet, Denis, Service d'endocrinologie, diabète et maladies métaboliques, Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Interactions cellulaires neuroendocriniennes (ICN), Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS), Institut de biologie et chimie des protéines [Lyon] (IBCP), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)

Subjects
Embryonic and Fetal Development, Neurotransmitter Agents, Pituitary Hormones, Sheep, Adrenal Cortex Hormones, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Animals, Humans, Amino Acids, Macaca mulatta, ComputingMilieux_MISCELLANEOUS, Rats
Abstract

International audience; no abstract

Published
1991

14. Insulin-induced hypoglycemia stimulates corticotropin-releasing factor and arginine vasopressin secretion into hydrophysical portal blood of conscious, unrestrained rams

Author

Caraty, Alain, Grino, Michel, Locatelli, Aude, Guillaume, V., Boudouresque, F., Conte-Devolx, B., Oliver, Charlotte, ProdInra, Migration, Unité de recherche Physiologie de la reproduction des mammifères domestiques, Nouzilly, and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV] Life Sciences [q-bio], ADRENOCORTICOTROPINE, [SDV]Life Sciences [q-bio], CORTISOL, [INFO]Computer Science [cs], CRF, [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1990

15. CRF and AVP secretion into rat and sheep hypophysial portal blood

Author

Oliver, Charlotte, Guillaume, V., Grino, Michel, Caraty, Alain, Conte-Devolx, B., Boudouresque, F., Unité de recherche Physiologie de la reproduction des mammifères domestiques, Nouzilly, Institut National de la Recherche Agronomique (INRA), D.K. Ludecke (Editeur), G.P. Chouros (Editeur), G. Tolis (Editeur), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], CRH, [SDV]Life Sciences [q-bio], RAT, [INFO]Computer Science [cs], [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1990

29. Protection against henipavirus infection by use of recombinant adeno-associated virus-vector vaccines.

Author

Ploquin A, Szécsi J, Mathieu C, Guillaume V, Barateau V, Ong KC, Wong KT, Cosset FL, Horvat B, Salvetti A, Ploquin, Aurélie, Szécsi, Judit, Mathieu, Cyrille, Guillaume, Vanessa, Barateau, Véronique, Ong, Kien Chai, Wong, Kum Thong, Cosset, François-Loïc, Horvat, Branka, and Salvetti, Anna

Abstract

Nipah virus (NiV) and Hendra virus (HeV) are closely related, recently emerged paramyxoviruses that are capable of causing considerable morbidity and mortality in several mammalian species, including humans. Henipavirus-specific vaccines are still commercially unavailable, and development of novel antiviral strategies to prevent lethal infections due to henipaviruses is highly desirable. Here we describe the development of adeno-associated virus (AAV) vaccines expressing the NiV G protein. Characterization of these vaccines in mice demonstrated that a single intramuscular AAV injection was sufficient to induce a potent and long-lasting antibody response. Translational studies in hamsters further demonstrated that all vaccinated animals were protected against lethal challenge with NiV. In addition, this vaccine induced a cross-protective immune response that was able to protect 50% of the animals against a challenge by HeV. This study presents a new efficient vaccination strategy against henipaviruses and opens novel perspectives on the use of AAV vectors as vaccines against emergent diseases. [ABSTRACT FROM AUTHOR]

Published
2013
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36. Synthesis of the Bis(iron) Carbene Complex [Cp*(dppe)FeC(OMe)CHCHC(OMe)Fe(dppe)Cp*][PF<INF>6</INF>]<INF>2</INF>:  A Binuclear Organometallic Compound with a Low-Spin ↔ High-Spin Interconversion

Author

Guillaume, V., Mahias, V., Mari, A., and Lapinte, C.

Abstract

The new diiron μ-bis(carbene) complex [Cp*(dppe)Fe&dbd;C(OCH3)-CH&dbd;CHC−(OCH3)&dbd;Fe(dppe)Cp*][PF6]2 (4) [Cp* = pentamethylcyclopentadienyl, dppe = ethylenebis(diphenylphosphine)] was obtained by double deprotonation of [Cp*(dppe)Fe&dbd;C(OCH3)CH2CH2C(OCH3)Fe(dppe)Cp*]·2[PF6] (2) with KOBut followed by a two-electron oxidation with 2 equiv of ferrocenium (80%). On the basis of the multinuclear NMR spectroscopy the complex 4 appeared as diamagnetic in solution. Temperature-dependent magnetic susceptibility measurements with a microcrystalline sample of 4 showed antiferromagnetic behavior. Isotropic spin-only models of the data derived magnetic exchange coupling constants of J = − 27.4 cm-1. Variable-temperature Mössbauer spectroscopy allowed the observation of both the singlet and triplet spin isomers and their interconversion. The time scale for the spin flipping is larger than 10-6 s, suggesting the existence of a thermal barrier between the two spin states.

Published
2000

39. Biosynthesis, metabolism and role of TRH during the perinatal period (minireview)

Author

Oliver, C., Dutour, A., L’Houcine Ouafik, Kolodziej-Maciejewska, H., Guillaume, V., Salers, P., Giraud, P., Ouafik, L'Houcine, INSERM U 297 - Laboratoire de Neuroendocrinologie Expérimentale, and Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Central Nervous System, MESH: Perinatology, MESH: Rats, [SDV.CAN]Life Sciences [q-bio]/Cancer, MESH: Pancreas, Perinatology, MESH: Animals, Newborn, Rats, [SDV.CAN] Life Sciences [q-bio]/Cancer, Animals, Newborn, MESH: Thyrotropin-Releasing Hormone, MESH: Central Nervous System, Animals, MESH: Animals, Pancreas, Thyrotropin-Releasing Hormone, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1986

41. Developmental aspects of the hypothalamic‐pituitary‐adrenal axis in the rat

Author

Grino, M., Boudouresque, F., Chautard, T., Denis Becquet, Guillaume, V., Strbák, V., Oliver, C., Interactions cellulaires neuroendocriniennes (ICN), Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS), Institut de biologie et chimie des protéines [Lyon] (IBCP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Service d'endocrinologie, diabète et maladies métaboliques, Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), and Becquet, Denis

Subjects
Hypothalamo-Hypophyseal System, Fetus, Pregnancy, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Animals, Pituitary-Adrenal System, Female, ComputingMilieux_MISCELLANEOUS, Rats
Abstract

International audience; no abstract

45. Monachium Utriusque Bavariae Civitas Primar.

Author

Hoefnagel, Joris (1542-1600). Dessinateur. Dédicateur, Guillaume V (1548-1626 ; duc de Bavière). Dédicataire, Hoefnagel, Joris (1542-1600). Dessinateur. Dédicateur, and Guillaume V (1548-1626 ; duc de Bavière). Dédicataire

Abstract

Échelle(s) : [Sans échelle (exprimée)], Référence bibliographique : 41:1.4(1635)

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