31 results on '"Guilhot, Florence"'
Search Results
2. Improved antibody pharmacokinetics by disruption of contiguous positive surface potential and charge reduction using alternate human framework
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Ollier, Romain, primary, Fuchs, Aline, additional, Gauye, Florence, additional, Piorkowska, Katarzyna, additional, Menant, Sébastien, additional, Ratnam, Monisha, additional, Montanari, Paolo, additional, Guilhot, Florence, additional, Phillipe, Didier, additional, Audrain, Mickael, additional, Egesipe, Anne-Laure, additional, Névoltris, Damien, additional, Seredenina, Tamara, additional, Pfeifer, Andrea, additional, Kosco-Vilbois, Marie, additional, and Afroz, Tariq, additional
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- 2023
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3. Novel Insights into Interleukin 6 (IL-6) Cis- and Trans-signaling Pathways by Differentially Manipulating the Assembly of the IL-6 Signaling Complex
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Lacroix, Marine, Rousseau, François, Guilhot, Florence, Malinge, Pauline, Magistrelli, Giovanni, Herren, Suzanne, Jones, Simon A., Jones, Gareth W., Scheller, Jürgen, Lissilaa, Rami, Kosco-Vilbois, Marie, Johnson, Zoë, Buatois, Vanessa, and Ferlin, Walter
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- 2015
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4. Targeting amyotrophic lateral sclerosis by neutralizing seeding-competent TDP-43 in CSF
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Audrain, Mickael, primary, Egesipe, Anne-Laure, additional, Tentillier, Noémie, additional, Font, Laure, additional, Ratnam, Monisha, additional, Mottier, Lorene, additional, Clavel, Mathieu, additional, Le Roux-Bourdieu, Morgan, additional, Fenyi, Alexis, additional, Ollier, Romain, additional, Chevalier, Elodie, additional, Guilhot, Florence, additional, Fuchs, Aline, additional, Piorkowska, Kasia, additional, Carlyle, Becky, additional, Arnold, Steven E, additional, Berry, James D, additional, Luthi-Carter, Ruth, additional, Adolfsson, Oskar, additional, Pfeifer, Andrea, additional, Kosco-Vilbois, Marie, additional, Seredenina, Tamara, additional, and Afroz, Tariq, additional
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- 2023
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5. Poèmes - NOUVELLE EDITION
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Lord Byron, Paul, Jean-Louis, Guilhot, Florence, Lord Byron, Lord Byron, Paul, Jean-Louis, Guilhot, Florence, and Lord Byron
- Abstract
Les présents poèmes sont choisis parmi les pièces isolées rangées par les éditions anglaises sous les titres Domestic pieces et Occasional pieces. Les grands poèmes de 1816 (Ténèbres, Prométhée) sont écrits en Suisse, lors du séjour à la villa Diodati où Byron fréquenta Shelley, et où il s’était exilé après que ses relations avec sa demi-sœur Augusta Leigh (à qui sont dédiés les Stances et l’Épître donnés dans ce recueil) eussent achevé de briser son mariage et justifié son exclusion par la grande société anglaise. Poète dandy, Lord Byron (1788-1824) a écrit une œuvre empreinte de mélancolie. Mais aussi de rébellion. Mis au ban, par l'aristocratie à la suite de scandales, aussi bien publics que domestiques, il quitta l'Angleterre, se réfugia en Suisse puis en Italie. Mais il était alors déjà entré dans la légende, incarnant le romantique révolté par excellence. Son œuvre et sa vie ont remporté l'admiration de Shelley et de Goethe. Allia a déjà publié Poèmes (1997), Caïn (2004) et Manfred (2013).
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- 2022
6. Inhibition of Classic Signaling Is a Novel Function of Soluble Glycoprotein 130 (sgp130), Which Is Controlled by the Ratio of Interleukin 6 and Soluble Interleukin 6 Receptor
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Garbers, Christoph, Thaiss, Wolfgang, Jones, Gareth W., Waetzig, Georg H., Lorenzen, Inken, Guilhot, Florence, Lissilaa, Rami, Ferlin, Walter G., Grötzinger, Joachim, Jones, Simon A., Rose-John, Stefan, and Scheller, Jürgen
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- 2011
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7. Inactivation of Cardiotrophin-Like Cytokine, a Second Ligand for Ciliary Neurotrophic Factor Receptor, Leads to Cold-Induced Sweating Syndrome in a Patient
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Rousseau, François, Gauchat, Jean-François, McLeod, James G., Chevalier, Sylvie, Guillet, Catherine, Guilhot, Florence, Cognet, Isabelle, Froger, Josy, Hahn, Angelika F., Knappskog, Per M., Gascan, Hugues, and Boman, Helge
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- 2006
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8. Elevated circulating levels of interferon-γ and interferon-γ-induced chemokines characterise patients with macrophage activation syndrome complicating systemic juvenile idiopathic arthritis
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Bracaglia, Claudia, de Graaf, Kathy, Pires Marafon, Denise, Guilhot, Florence, Ferlin, Walter, Prencipe, Giusi, Caiello, Ivan, Davì, Sergio, Schulert, Grant, Ravelli, Angelo, Grom, Alexei A, de Min, Cristina, and De Benedetti, Fabrizio
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- 2017
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9. Rapid, simple and high yield production of recombinant proteins in mammalian cells using a versatile episomal system
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Magistrelli, Giovanni, Malinge, Pauline, Lissilaa, Rami, Fagète, Séverine, Guilhot, Florence, Moine, Valéry, Buatois, Vanessa, Delneste, Yves, Kellenberger, Stephan, Gueneau, Franck, Ravn, Ulla, Kosco-Vilbois, Marie, and Fischer, Nicolas
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- 2010
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10. Continued Administration of Ciliary Neurotrophic Factor Protects Mice from Inflammatory Pathology in Experimental Autoimmune Encephalomyelitis
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Kuhlmann, Tanja, Remington, Leah, Cognet, Isabelle, Bourbonniere, Lyne, Zehntner, Simone, Guilhot, Florence, Herman, Alexandra, Guay-Giroux, Angélique, Antel, Jack P., Owens, Trevor, and Gauchat, Jean-François
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- 2006
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11. CC chemokine CCL5 plays a central role impacting infarct size and post-infarction heart failure in mice
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Montecucco, Fabrizio, Braunersreuther, Vincent, Lenglet, Sébastien, Delattre, Benedicte M.A., Pelli, Graziano, Buatois, Vanessa, Guilhot, Florence, Galan, Katia, Vuilleumier, Nicolas, Ferlin, Walter, Fischer, Nicolas, Vallée, Jean-Paul, Kosco-Vilbois, Marie, and Mach, François
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- 2012
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12. High Ionic Strength Dissociation Assay (HISDA) for High Drug Tolerant Immunogenicity Testing
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Jordan, Gregor, primary, Pöhler, Alexander, additional, Guilhot, Florence, additional, Zaspel, Meike, additional, and Staack, Roland F, additional
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- 2020
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13. The IL-27 p28 subunit binds CLF to form a cytokine regulating NK and T cell activities requiring IL-6R for signaling
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Crabé, Sandrine, Guay-Giroux, Angélique, Tormo, Aurélie, Duluc, Dorothée, Lissilaa, Rami, Guilhot, Florence, Mavoungou-Bigouagou, Ulrick, Lefouili, Fouad, Cognet, Isabelle, Ferlin, Walter, Elson, Greg, Jeannin, Pascale, and Gauchat, Jean-François
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- 2009
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14. Cardiotrophin-like cytokine labelling using Bir A biotin ligase: A sensitive tool to study receptor expression by immune and non-immune cells
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Cognet, Isabelle, Guilhot, Florence, Gabriac, Mélanie, Chevalier, Sylvie, Chouikh, Younes, Herman-Bert, Alexandra, Guay-Giroux, Angélique, Corneau, Sophie, Magistrelli, Giovanni, Elson, Greg C., Gascan, Hugues, and Gauchat, Jean-François
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- 2005
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15. Poèmes
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Lord Byron, Paul, Jean-Louis, Guilhot, Florence, Lord Byron, Lord Byron, Paul, Jean-Louis, Guilhot, Florence, and Lord Byron
- Abstract
À ces êtres qui ne m'ont jamais plu ! Poète dandy, Lord Byron (1788-1824) a écrit une œuvre empreinte de mélancolie. Mais aussi de rébellion. Mis au ban, par l'aristocratie à la suite de scandales, aussi bien publics que domestiques, il quitta l'Angleterre, se réfugia en Suisse puis en Italie. Mais il était alors déjà entré dans la légende, incarnant le romantique révolté par excellence. Son œuvre et sa vie ont remporté l'admiration de Shelley et de Goethe, et inspiré Delacroix et Berlioz. Allia a déjà publié Poèmes et Caïn.
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- 2019
16. NI‐0801, an anti‐chemokine (C‐X‐C motif) ligand 10 antibody, in patients with primary biliary cholangitis and an incomplete response to ursodeoxycholic acid
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de Graaf, Kathy L., primary, Lapeyre, Geneviève, additional, Guilhot, Florence, additional, Ferlin, Walter, additional, Curbishley, Stuart M., additional, Carbone, Marco, additional, Richardson, Paul, additional, Moreea, Sulleman, additional, McCune, C. Anne, additional, Ryder, Stephen D., additional, Chapman, Roger W., additional, Floreani, Annarosa, additional, Jones, David E., additional, de Min, Cristina, additional, Adams, David H., additional, and Invernizzi, Pietro, additional
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- 2018
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17. NI-0801, an anti-chemokine (C-X-C motif) ligand 10 antibody, in patients with primary biliary cholangitis and an incomplete response to ursodeoxycholic acid
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de Graaf, K, Lapeyre, G, Guilhot, F, Ferlin, W, Curbishley, S, Carbone, M, Richardson, P, Moreea, S, Mccune, C, Ryder, S, Chapman, R, Floreani, A, Jones, D, de Min, C, Adams, D, Invernizzi, P, de Graaf, Kathy L, Lapeyre, Geneviève, Guilhot, Florence, Ferlin, Walter, Curbishley, Stuart M, Carbone, Marco, Richardson, Paul, Moreea, Sulleman, McCune, C Anne, Ryder, Stephen D, Chapman, Roger W, Floreani, Annarosa, Jones, David E, de Min, Cristina, Adams, David H, Invernizzi, Pietro, de Graaf, K, Lapeyre, G, Guilhot, F, Ferlin, W, Curbishley, S, Carbone, M, Richardson, P, Moreea, S, Mccune, C, Ryder, S, Chapman, R, Floreani, A, Jones, D, de Min, C, Adams, D, Invernizzi, P, de Graaf, Kathy L, Lapeyre, Geneviève, Guilhot, Florence, Ferlin, Walter, Curbishley, Stuart M, Carbone, Marco, Richardson, Paul, Moreea, Sulleman, McCune, C Anne, Ryder, Stephen D, Chapman, Roger W, Floreani, Annarosa, Jones, David E, de Min, Cristina, Adams, David H, and Invernizzi, Pietro
- Abstract
NI-0801 is a fully human monoclonal antibody against chemokine (C-X-C motif) ligand 10 (CXCL10), which is involved in the recruitment of inflammatory T cells into the liver. The safety and efficacy of NI-0801 was assessed in patients with primary biliary cholangitis. In this open-label phase 2a study, patients with primary biliary cholangitis with an inadequate response to ursodeoxycholic acid received six consecutive intravenous administrations of NI-0801 (10 mg/kg) every 2 weeks. Patients were followed up for 3 months after the last infusion. Liver function tests, safety assessments, as well as pharmacokinetic and pharmacodynamic parameters were evaluated at different time points throughout the dosing period and the safety follow-up period. Twenty-nine patients were enrolled in the study and were treated with NI-0801. The most frequently reported adverse events included headaches (52%), pruritus (34%), fatigue (24%), and diarrhea (21%). No study drug-related serious adverse events were reported. NI-0801 administration did not lead to a significant reduction in any of the liver function tests assessed at the end of the treatment period (i.e., 2 weeks after final NI-0801 administration) compared to baseline. Conclusion: Despite clear pharmacologic responses in the blood, no therapeutic benefit of multiple administrations of NI-0801 could be demonstrated. The high production rate of CXCL10 makes it difficult to achieve drug levels that lead to sustained neutralization of the chemokine, thus limiting its targetability.
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- 2018
18. CC chemokine CCL5 plays a central role impacting infarct size and post-infarction heart failure in mice
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Montecucco, Fabrizio, Braunersreuther, Vincent, Lenglet, Sébastien, Delattre, Benedicte M.A., Pelli, Graziano, Buatois, Vanessa, Guilhot, Florence, Galan, Katia, Vuilleumier, Nicolas, Ferlin, Walter, Fischer, Nicolas, Vallée, Jean-Paul, Kosco-Vilbois, Marie, Mach, François, Montecucco, Fabrizio, Braunersreuther, Vincent, Lenglet, Sébastien, Delattre, Benedicte M.A., Pelli, Graziano, Buatois, Vanessa, Guilhot, Florence, Galan, Katia, Vuilleumier, Nicolas, Ferlin, Walter, Fischer, Nicolas, Vallée, Jean-Paul, Kosco-Vilbois, Marie, and Mach, François
- Abstract
Aims The chemokine CCL5 plays a critical role as neutrophil and macrophage activator do in atherosclerosis and myocardial infarction. Thus, we investigated whether the treatment with a neutralizing monoclonal antibody (mAb) to mouse CCL5 would provide therapeutic benefit when provoking a coronary-associated ischaemic event. Methods and Results C57Bl/6 mice were submitted to left coronary artery permanent ligature. Then, various parameters were monitored for up to 21 days. At5 min and 3days after coronary occlusion, mice received one intravenous injection of the rat anti-mouse CCL5 mAb or isotype IgG control. Infarct size was assessed histologically and by measuring serum cardiac troponin I levels. Kinetics of CCL5 tissue expression, leucocyte infiltration, matrix metalloproteinase (MMP) levels, and collagen deposition were histologically assessed. Serum chemokine levels were measured by enzyme-linked immunosorbent assay. Cardiac function and dimensions were assessed by magnetic resonance imaging (MRI). Chronic ischaemia increased both circulating and intracardiac levels of CCL5. At 24 h, treatment with the anti-CCL5 mAb resulted in a smaller infarct size and reduced circulating levels of chemokines. This effect was associated with reduction of neutrophil and macrophage infiltration within the infarcted myocardium. After 3 days of chronic ischaemia, anti-CCL5 mAb treatment reduced cardiac MMP-9. At 7 days, collagen content was significantly lower. At 21 days, neutralizing CCL5 improved mouse survival, cardiac myocyte size, and cardiac function. Conclusion Treatment with anti-CCL5 mAb significantly reduced both infarct size and post-infarction heart failure in a mouse model of chronic cardiac ischaemia. Cardioprotective effects were associated with the reduction of leucocyte recruitment within infarcted hearts
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- 2017
19. Elevated circulating levels of interferon-γ and interferon-γ-induced chemokines characterise patients with macrophage activation syndrome complicating systemic juvenile idiopathic arthritis
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Bracaglia, Claudia, primary, de Graaf, Kathy, additional, Pires Marafon, Denise, additional, Guilhot, Florence, additional, Ferlin, Walter, additional, Prencipe, Giusi, additional, Caiello, Ivan, additional, Davì, Sergio, additional, Schulert, Grant, additional, Ravelli, Angelo, additional, Grom, Alexei A, additional, de Min, Cristina, additional, and De Benedetti, Fabrizio, additional
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- 2016
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20. Rôle des ligands du récepteur au CNTF dans le développement et étude de la signalisation induite par ces cytokines dans des modèles cellulaires de cancer
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Guilhot, Florence and Gauchat, Jean-François
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CLC/CLF ,CNTF ,Neuropoiétine ,Souris Knock-Out ,Cancer du sein ,CNTFR - Abstract
Thèse numérisée par la Direction des bibliothèques de l'Université de Montréal.
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- 2007
21. Detection of e Class Switching and IgE Synthesis in Human B Cells
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Pene, Jerome, primary, Guilhot, Florence, additional, Cognet, Isabelle, additional, Guglielmi, Paul, additional, Guay-Giroux, Angélique, additional, Bonnefoy, Jean-Yves, additional, Elson, Greg C., additional, Yssel, Hans, additional, and Gauchat, Jean-François, additional
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22. Interferon-gamma (IFNy) in macrophage activation syndrome (MAS) associated with systemic juvenile idiopathic arthritis (sJIA). High levels in patients and a role in a murine mas model
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Bracaglia, Claudia, primary, Caiello, Ivan, additional, De Graaf, Kathy, additional, D'Ario, Giovanni, additional, Guilhot, Florence, additional, Ferlin, Walter, additional, Melli, Lidia, additional, Prencipe, Giusi, additional, Davì, Sergio, additional, Schulert, Grant, additional, Ravelli, Angelo, additional, Grom, Alexei, additional, De Min, Cristina, additional, and De Benedetti, Fabrizio, additional
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- 2014
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23. CC chemokine CCL5 plays a central role impacting infarct size and post-infarction heart failure in mice
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Montecucco, Fabrizio, primary, Braunersreuther, Vincent, additional, Lenglet, Sébastien, additional, Delattre, Benedicte M.A., additional, Pelli, Graziano, additional, Buatois, Vanessa, additional, Guilhot, Florence, additional, Galan, Katia, additional, Vuilleumier, Nicolas, additional, Ferlin, Walter, additional, Fischer, Nicolas, additional, Vallée, Jean-Paul, additional, Kosco-Vilbois, Marie, additional, and Mach, François, additional
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- 2011
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24. Although IL-6 Trans-Signaling Is Sufficient To Drive Local Immune Responses, Classical IL-6 Signaling Is Obligate for the Induction of T Cell-Mediated Autoimmunity
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Lissilaa, Rami, primary, Buatois, Vanessa, additional, Magistrelli, Giovanni, additional, Williams, Anwen S., additional, Jones, Gareth W., additional, Herren, Suzanne, additional, Shang, Limin, additional, Malinge, Pauline, additional, Guilhot, Florence, additional, Chatel, Laurence, additional, Hatterer, Eric, additional, Jones, Simon A., additional, Kosco-Vilbois, Marie H., additional, and Ferlin, Walter G., additional
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- 2010
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25. The IL-27 p28 Subunit Binds Cytokine-Like Factor 1 to Form a Cytokine Regulating NK and T Cell Activities Requiring IL-6R for Signaling
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Crabé, Sandrine, primary, Guay-Giroux, Angélique, additional, Tormo, Aurélie Jeanne, additional, Duluc, Dorothée, additional, Lissilaa, Rami, additional, Guilhot, Florence, additional, Mavoungou-Bigouagou, Ulrick, additional, Lefouili, Fouad, additional, Cognet, Isabelle, additional, Ferlin, Walter, additional, Elson, Greg, additional, Jeannin, Pascale, additional, and Gauchat, Jean-François, additional
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- 2009
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26. Detection of ε Class Switching and IgE Synthesis in Human B Cells.
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Walker, John M., Krishnaswamy, Guha, Chi, David S., Pène, Jérôme, Guilhot, Florence, Cognet, Isabelle, Guglielmi, Paul, Guay-Giroux, Angélique, Bonnefoy, Jean-Yves, Elson, Greg C., Yssel, Hans, and Gauchat, Jean-François
- Abstract
We observed that mast cells, as other cells expressing the CD40 ligand CD154, can trigger IgE synthesis in B cells in the presence of interleukin (IL)-4. Numerous complementary techniques can be used to follow the succession of molecular events leading to IgE synthesis. This chapter will illustrate how human B cells (naïve or memory) can be purified, stored, and cultivated in medium that is permissive for IgE synthesis and stimulated with IL-4 or IL-13 and CD40 activation, the latter being induced by soluble CD154, anti-CD40 antibodies, or CD154-expressing cells. All these molecules are expressed by mast cells. The quantification of the ε-sterile transcript synthesis by polymerase chain reaction or Northern blot, the ε excision circles produced during immunoglobulin heavy chain locus rearrangement by polymerase chain reaction, and the IgE production by enzyme-linked immunosorbent assay will be described. [ABSTRACT FROM AUTHOR]
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- 2005
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27. Proceedings of the 23rd Paediatric Rheumatology European Society Congress: part two: Genoa, Italy. 28 September – 01 October 2016
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Lomakina, Olga, Alekseeva, Ekaterina, Valieva, Sania, Bzarova, Tatiana, Nikishina, Irina, Zholobova, Elena, Rodionovskaya, Svetlana, Kaleda, Maria, Nakagishi, Yasuo, Shimizu, Masaki, Mizuta, Mao, Yachie, Akihiro, Sugita, Yuko, Okamoto, Nami, Shabana, Kousuke, Murata, Takuji, Tamai, Hiroshi, Smith, Eve M., Yin, Peng, Jorgensen, Andrea L., Beresford, Michael W., Eleuteri, Antonio, Goilav, Beatrice, Lewandowski, Laura, Phuti, Angel, Wahezi, Dawn, Rubinstein, Tamar, Jones, Caroline, Newland, Paul, Marks, Stephen, Corkhill, Rachel, Ekdawy, Diana, Pilkington, Clarissa, Tullus, Kjell, Putterman, Chaim, Scott, Chris, Fisher, Antony C., Jorgensen, Andrea, Batu, Ezgi Deniz, Kosukcu, Can, Taskiran, Ekim, Akman, Sema, Ozturk, Kubra, Sozeri, Betul, Unsal, Erbil, Ekinci, Zelal, Bilginer, Yelda, Alikasifoglu, Mehmet, Ozen, Seza, Lythgoe, Hanna, Brunner, Hermine I., Gulati, Gaurav, Jones, Jordan T., Altaye, Mekibib, Eaton, Jamie, Difrancesco, Mark, Yeo, Joo Guan, Leong, Jingyao, Bathi, Loshinidevi D/O Thana, Arkachaisri, Thaschawee, Albani, Salvatore, Abdelrahman, Nagla, Beresford, Michael W, Leone, Valentina, Groot, Noortje, Shaikhani, D., Bultink, I. E. M., Bijl, M., Dolhain, R. J. E. M., Teng, Y. K. O., Zirkzee, E., de Leeuw, K., Fritsch-Stork, R., Kamphuis, S. S. M., Wright, Rachael D., Abdawani, Reem, Al Shaqshi, Laila, Al Zakwani, Ibrahim, Gormezano, Natali W., Kern, David, Pereira, Oriany L., Esteves, Gladys C. C., Sallum, Adriana M., Aikawa, Nadia E., Pereira, Rosa M., Silva, Clovis A., Bonfa, Eloisa, Beckmann, Jessica, Bartholomä, Nora, Venhoff, Nils, Henneke, Philipp, Salzer, Ulrich, Janda, Ales, Boteanu, Alina Lucica, Corral, Sandra Garrote, Giraldo, Alberto Sifuentes, Gámir, Mariluz Gámir, Mendoza, Antonio Zea, Adrovic, Amra, Dedeoglu, Reyhan, Sahin, Sezgin, Barut, Kenan, Koka, Aida, Oztunc, Funda, Kasapcopur, Ozgur, Rodriguez-Lozano, Ana Luisa, Rivas-Larrauri, Francisco, de la Puente, Silvestre García, Alves, Andressa G. F., Giacomin, Maria F. D. A., Farhat, Juliana, Braga, Alfésio L. F., Sallum, Adriana M. E., Campos, Lúcia M. D. A., Pereira, Luiz A. A., Lichtenfels, Ana J. D. F. C., Silva, Clóvis A., Farhat, Sylvia C. L., Acar, Banu, Ozcakar, Z. Birsin, Çakar, Nilgün, Uncu, Nermin, Gür, Gökçe, Özdel, Semanur, Yalçınkaya, Fatoş, Scott, Christiaan, Brice, Nicky, Nourse, Peter, Arango, Christine, Mosquera, Angela C., Malagon, Clara, Sakamoto, Ana P., Silva, Marco F. C. D., Lopes, Ananadreia S., Russo, Gleice C. S., Sallum, Adriana E. M., Kozu, Katia, Bonfá, Eloisa, Saad-Magalhães, Claudia, Pereira, Rosa M. R., Len, Claudio A., Terreri, Maria T., Suri, Deepti, Didel, Siyaram, Rawat, Amit, Singh, Surjit, Maritsi, Despoina, Onoufriou, MArgarita, Vougiouka, Olga, Tsolia, Maria, Bosak, Edi Paleka, Vidović, Mandica, Lamot, Mirta, Lamot, Lovro, Harjaček, Miroslav, Van Nieuwenhove, Erika, Liston, Adrian, Wouters, Carine, Tahghighi, Fatemeh, Ziaee, Vahid, Raeeskarami, Seid-Reza, Aguiar, Francisca, Pereira, Sandra, Rodrigues, Mariana, Moura, Cláudia, Rocha, Gustavo, Guimarães, Hercília, Brito, Iva, Fonseca, Rita, Horneff, Gerd, Klein, Ariane, Minden, Kirsten, Huppertz, Hans-Iko, Weller-Heinemann, Frank, Kuemmerle-Deschner, Jasmin, Haas, J-Peter, Hospach, Anton, Menendez-Castro, Ricardo, Huegle, Boris, Haas, Johannes-Peter, Swart, Joost, Giancane, Gabriella, Bovis, Francesca, Castagnola, Elio, Groll, Andreas, Lovell, Daniel J., Wolfs, Tom, Hofer, Michael, Panaviene, Violeta, Nielsen, Susan, Anton, Jordi, Uettwiller, Florence, Stanevicha, Valda, Trachana, Maria, Marafon, Denise Pires, Ailioaie, Constantin, Tsitsami, Elena, Kamphuis, Sylvia, Herlin, Troels, Doležalová, Pavla, Susic, Gordana, Flatø, Berit, Sztajnbok, Flavio, Pistorio, Angela, Martini, Alberto, Wulffraat, Nico, Ruperto, Nicolino, Gattorno, Marco, Brucato, Antonio, Finetti, Martina, Lazaros, George, Maestroni, Silvia, Carraro, Mara, Cumetti, Davide, Carobbio, Alessandra, Lorini, Monia, Rimini, Alessandro, Marcolongo, Renzo, Valenti, Anna, Erre, Gian Luca, Belli, Riccardo, Gaita, Fiorenzo, Sormani, Maria Pia, Imazio, Massimo, Abinun, Mario, Smith, Nicola, Rapley, Tim, McErlane, Flora, Kearsley-Fleet, Lianne, Hyrich, Kimme L., Foster, Helen, Tzaribachev, Nikolay, Zeft, Andrew, Cimaz, Rolando, Bohnsack, John, Griffin, Thomas, Carrasco, Ruy, Dare, Jason, Foeldvari, Ivan, Vehe, Richard, Simon, Teresa, Brunner, Hermine, Verazza, S., Davì, S., Consolaro, A., Insalaco, A., Gerloni, V., Cimaz, R., Zulian, F., Pastore, S., Corona, F., Conti, G., Barone, P., Cattalini, M., Cortis, E., Breda, L., Olivieri, A. N., Civino, A., Podda, R., Rigante, D., La Torre, F., D’Angelo, G., Jorini, M., Gallizzi, R., Maggio, M. C., Consolini, R., De Fanti, A., Alpigiani, M. G., Martini, A., Ravelli, A., Kısaarslan, Aysenur Pac, Gunduz, Zubeyde, Dusunsel, Ruhan, Dursun, Ismail, Poyrazoglu, Hakan, Kuchinskaya, Ekaterina, Abduragimova, Farida, Kostik, Mikhail, Sundberg, Erik, Omarsdottir, Soley, Klevenvall, Lena, Erlandsson-Harris, Helena, Basbozkurt, Gokalp, Erdemli, Ozge, Simsek, Dogan, Yazici, Fatih, Karsioglu, Yildirim, Tezcaner, Aysen, Keskin, Dilek, Ozkan, Huseyin, Acikel, Cengizhan, Demirkaya, Erkan, Orbán, Ilonka, Sevcic, Krisztina, Brodszky, Valentin, Kiss, Emese, Tekko, Ismaiel A., Rooney, Madeleine, McElnay, James, Taggart, Cliff, McCarthy, Helen, Donnelly, Ryan F., Slatter, Mary, Nademi, Zohreh, Friswell, Mark, Jandial, Sharmila, Flood, Terence, Hambleton, Sophie, Gennery, Andrew, Cant, Andrew, Duong, Phoi-Ngoc, Koné-Paut, Isabelle, Filocamo, Giovanni, Gamir, María Luz, Sanner, Helga, Carenini, Laura, Topdemir, Mesut, Karslioglu, Yildirim, Gok, Faysal, Tsurikova, Nadezhda, Ligostaeva, Elena, Ramchurn, Navdha R., Kostareva, O., Nikishina, I., Arsenyeva, S., Rodionovskaya, S., Kaleda, M., Alexeev, D., Dursun, Ismail Dursun, Murias, Sara, Barral, Estefania, Alcobendas, Rosa, Enriquez, Eugenia, Remesal, Agustin, de Inocencio, Jaime, Castro, Tania M., Lotufo, Simone A., Freye, Tatjana, Carlomagno, Raffaella, Zumbrunn, Thomas, Bonhoeffer, Jan, Schneider, Elvira Cannizzaro, Kaiser, Daniela, Hofer, Michaël, Hentgen, Véronique, Woerner, Andreas, Schwarz, Tobias, Klotsche, Jens, Niewerth, Martina, Ganser, Gerd, Jeyaratnam, Jerold, ter Haar, Nienke, Rigante, Donato, Dedeoglu, Fatma, Baris, Ezgi, Vastert, Sebastiaan, Frenkel, Joost, Hausmann, Jonathan S., Lomax, Kathleen G., Shapiro, Ari, Durrant, Karen L., Brogan, P. A., Hofer, M., Kuemmerle-Deschner, J. B., Lauwerys, B., Speziale, A., Leon, K., Wei, X., Laxer, R. M., Signa, Sara, Rusmini, Marta, Campione, Elena, Chiesa, Sabrina, Grossi, Alice, Omenetti, Alessia, Caorsi, Roberta, Viglizzo, Gianmaria, Ceccherini, Isabella, Federici, Silvia, Lachmann, Helen, Ruperto, Nicola, Vanoni, Federica, Gomes, Sonia Melo, Omoyinmi, Ebun, Arostegui, Juan I., Gonzalez-Roca, Eva, Eleftheriou, Despina, Klein, Nigel, Brogan, Paul, Volpi, Stefano, Santori, Elettra, Picco, Paolo, Pastorino, Claudia, Rice, Gillian, Tesser, Alessandra, Crow, Yanick, Candotti, Fabio, Sinoplu, Ada B., Yucel, Gozde, Pamuk, Gizem, Damian, Laura O., Lazea, Cecilia, Sparchez, Mihaela, Vele, Paulina, Muntean, Laura, Albu, Adriana, Rednic, Simona, Lazar, Calin, Mendonça, Leonardo O., Pontillo, Alessandra, Kalil, Jorge, Castro, Fabio M., Barros, Myrthes T., Pardeo, Manuela, Messia, Virginia, De Benedetti, Fabrizio, Insalaco, Antonella, Malighetti, Giorgia, Gorio, Chiara, Ricci, Francesca, Parissenti, Ilaria, Montesano, Paola, Bonafini, Barbara, Medeghini, Veronica, Cattalini, Marco, Giordano, Lucio, Zani, Giulia, Ferraro, Rosalba, Vairo, Donatella, Giliani, Silvia, Maggio, Maria Cristina, Luppino, Girolamo, Corsello, Giovanni, Fernandez, Maria Isabel Gonzalez, Montesinos, Berta Lopez, Vidal, Adriana Rodriguez, Gorospe, Juan I. Arostegui, Penades, Inmaculada Calvo, Rafiq, Nadia K., Wynne, Karen, Hussain, Khalid, Brogan, Paul A., Ang, Elizabeth, Ng, Nicholas, Kacar, Ayla, Gucenmez, Ozge Altug, Makay, Balahan, Unsal, Sevket Erbil, Sahin, Yasin, Kutlu, Tufan, Cullu-Cokugras, Fugen, Ayyildiz-Civan, Hasret, Erkan, Tulay, Al Zuhbi, Sana, Abdalla, Eiman, Russo, Ricardo A., Katsicas, María M., Minoia, Francesca, Ravelli, Angelo, Bhattad, Sagar, Gupta, Anju, Pandiarajan, Vignesh, Nada, Ritambhra, Tiewsoh, Kaara, Hawkins, Philip, Rowczenio, Dorota, Fingerhutova, Sarka, Franova, Jana, Prochazkova, Leona, Hlavackova, Eva, Dolezalova, Pavla, Evrengül, Havva, Yüksel, Selçuk, Doğan, Mustafa, Gürses, Dolunay, Evrengül, Harun, De Pauli, Silvia, Pastore, Serena, Bianco, Anna Monica, Severini, Giovanni Maria, Taddio, Andrea, Tommasini, Alberto, Salugina, Svetlana O., Fedorov, Evgeny, Kamenets, Elena, Zaharova, Ekaterina, Sleptsova, Tatiana, Alexeeva, Ekaterina, Savostyanov, Kirill, Pushkov, Alexander, Bzarova, Tatyana, Valieva, Saniya, Denisova, Rina, Isayeva, Kseniya, Chistyakova, Evgeniya, Soloshenko, Margarita, Kaschenko, Elena, Kaneko, Utako, Imai, Chihaya, Saitoh, Akihiko, Teixeira, Vitor A., Ramos, Filipa O., Costa, Manuela, Aviel, Yonatan Butbul, Fahoum, Shafe, Brik, Riva, Özçakar, Zeynep Birsin, Celikel, Banu Acar, Yalcinkaya, Fatos, Schiappapietra, Benedetta, Davi’, Sergio, Mongini, Federica, Giannone, Luisa, Bava, Cecilia, Alpigiani, Maria Giannina, Consolaro, Alessandro, Lazarevic, Dragana S., Vojinovic, Jelena, Basic, Jelena, Muratore, Valentina, Marzetti, Valentina, Quilis, Neus, Benavente, Belen Serrano, Alongi, Alessandra, Civino, Adele, Quartulli, Lorenzo, Januskeviciute, Giedre, van Dijkhuizen, Pieter, Groot, N., van Dijk, W., Kardolus, A., Suárez, Raul Gutiérrez, Nordal, Ellen B., Rypdal, Veronika G., Berntson, Lillemor, Ekelund, Maria, Aalto, Kristiina, Peltoniemi, Suvi, Zak, Marek, Glerup, Mia, Arnstad, Ellen D., Fasth, Anders, Rygg, Marite, Duarte, Ana Catarina, Sousa, Sandra, Teixeira, Lídia, Cordeiro, Ana, Santos, Mª José, Mourão, Ana Filipa, Santos, Maria José, Eusébio, Mónica, Lopes, Ana, Oliveira-Ramos, Filipa, Salgado, Manuel, Estanqueiro, Paula, Melo-Gomes, José, Martins, Fernando, Costa, José, Furtado, Carolina, Figueira, Ricardo, Branco, Jaime C., Fonseca, João E., Canhão, Helena, Mourão, Ana F., Santos, Maria Jose, Coda, Andrea, Cassidy, Samuel, West, Kerry, Hendry, Gordon, Grech, Debra, Jones, Julie, Hawke, Fiona, Grewal, Davinder Singh, Foley, Charlene, Killeen, Orla, MacDermott, Emma, Veale, Douglas, Fearon, Ursula, Konukbay, Dilek, Tarakci, Ela, Arman, Nilay, Şahin, Sezgin, Munro, Jane, Morgan, Esi, Riebschleger, Meredith, Horonjeff, Jennifer, Strand, Vibeke, Bingham, Clifton, Collante, Ma. Theresa M., Ganeva, Margarita, Stefanov, Stefan, Telcharova, Albena, Mihaylova, Dimitrina, Saraeva, Radoslava, Tzveova, Reni, Kaneva, Radka, Tsakova, Adelina, Temelkova, Katya, Picarelli, Maria Mercedes C., Danzmann, Luiz C., Barbé-Tuana, Florencia, Grun, Lucas K., Jones, Marcus H., Frković, Marijan, Ištuk, Karla, Birkić, Ika, Sršen, Saša, Jelušić, Marija, Easton, Alan, Quarmby, Rachael, Khubchandani, Raju, Chan, Mercedes, Srp, Radoslav, Kobrova, Katerina, Nemcova, Dana, Hoza, Jozef, Uher, Michal, Saifridova, Melania, Linkova, Lenka, Charuvanij, Sirirat, Leelayuwattanakul, Isree, Pacharapakornpong, Thita, Vallipakorn, Sakda A.-O., Lerkvaleekul, Butsabong, Vilaiyuk, Soamarat, Lanni, Stefano, Davì, Sergio, Cron, Randy Q., Passarelli, Chiara, Pisaneschi, Elisa, Novelli, Antonio, Bracaglia, Claudia, Caiello, Ivan, de Graaf, Kathy, Guilhot, Florence, Ferlin, Walter, Schulert, Grant, Grom, Alexi A., Nelson, Robert, de Min, Cristina, Holzinger, Dirk, Kessel, Christoph, Fall, Ndate, Grom, Alexei, de Jager, Wilco, Strippoli, Raffaele, Horne, Anna, Ehl, Stephan, Ammann, Sandra, Lehmberg, Kai, Beutel, Karin, Foell, Dirk, Horne, AnnaCarin, Pagani, Laura, Espada, Graciela, Gao, Yi-jin, Shenoi, Susan, Weitzman, Sheila, Prencipe, Giusi, Pascarella, Antonia, Ferlin, Walter G., Chatel, Laurence, Jacqmin, Philippe, De Graaf, Kathy, Ballabio, Maria, Johnson, Zoë, Lapeyre, Geneviève, de Benedetti, Fabrizio, Cristina, de Min, Wakiguchi, Hiroyuki, Hasegawa, Shunji, Hirano, Reiji, Okazaki, Fumiko, Nakamura, Tamaki, Kaneyasu, Hidenobu, Ohga, Shouichi, Yamazaki, Kazuko, Nozawa, Tomo, Kanetaka, Taichi, Ito, Shuichi, Yokota, Shumpei, McLellan, Kirsty, MacGregor, Ishbel, Martin, Neil, Davidson, Joyce, Hansmann, Sandra, Eikelberg, Andreas, Haug, Iris, Schuller, Sabrina, Benseler, Susanne M., Nazarova, Liliia S., Danilko, Kseniia V., Malievsky, Viktor A., Viktorova, Tatiana V., Mauro, Angela, Barnicoat, Angela, Hurst, Jane, Canham, Nathalie, Lacassagne, Sandrine, Wiener, Anastasia, Hügle, Boris, Denecke, Bernd, Costa-Filho, Ivan, Haas, Johannes Peter, Tenbrock, Klaus, Popp, David, Boltjes, Arjan, Rühle, Frank, Herresthal, Stefanie, van Wijk, Femke, Schultze, Joachim, Stoll, Monika, Klotz, Luisa, Vogl, Thomas, Roth, Johannes, Quesada-Masachs, Estefania, de la Sierra, Daniel Álvarez, Prat, Marina Garcia, Sánchez, Ana M. Marín, Borrell, Ricardo Pujol, Barril, Sara Marsal, Gallo, Mónica Martínez, Caballero, Consuelo Modesto, Chyzheuskaya, Iryna, Byelyaeva, Lyudmyla M., Filonovich, Rostislav M., Khrustaleva, Helena K., Zajtseva, Larisa I., Yuraga, Tamara M., Giner, Thomas, Hackl, Lukas, Albrecht, Julia, Würzner, Reinhard, Brunner, Juergen, Minute, Marta, Parentin, Fulvio, Nocerino, Agostino, Nørgaard, Mette, Alberdi-Saugstrup, Mikel, Zak, Marek S., Nielsen, Susan M., Nordal, Ellen, Müller, Klaus G., Avramovič, Mojca Zajc, Dolžan, Vita, Toplak, Nataša, Avčin, Tadej, Ruperto, N., Lovell, D. J., Wallace, C., Toth, M., Foeldvari, I., Bohnsack, J., Milojevic, D., Rabinovich, C., Kingsbury, D., Marzan, K., Quartier, P., Minden, K., Chalom, E., Horneff, G., Kuester, R. M., Dare, J., Heinrich, M., Kupper, H., Kalabic, J., Brunner, H. I., Burgos-Vargas, Ruben, Constantin, Tamas, Dehoorne, Joke, Stanevica, Valda, Kobusinska, Katarzyna, Zuber, Zbigniew, Mouy, Richard, Rumba-Rozenfelde, Ingrida, Job-Deslandre, Chantal, Pederson, Ronald, Bukowski, Jack, Hinnershitz, Tina, Vlahos, Bonnie, Keskitalo, Paula, Kangas, Salla, Vähäsalo, Paula, Valencia, Raul A. Chavez, Martino, David, Ponsonby, Anne-Louise, Chiaroni-Clarke, Rachel, Meyer, Braydon, Allen, Roger C., Akikusa, Jonathan D., Craig, Jeffrey M., Saffrey, Richard, Ellis, Justine A., Wallace, Carol, Uziel, Yosef, Sterba, Gary, Schneider, Rayfel, Russo, Ricardo, Ramanan, Athimalaipet V., Schmid, Jana Pachlopnik, Nichols, Kim E, Miettunen, Paivi, Kitoh, Toshiyuki, Ilowite, Norman T., Henter, Jan-Inge, Grom, Alexei A, Behrens, Edward M., Avcin, Tadej, Aricò, Maurizio, Grevich, Sriharsha, Lee, Peggy, Ringold, Sarah, Leroux, Brian, Leahey, Hannah, Yuasa, Megan, Foster, Jessica, Sokolove, Jeremy, Lahey, Lauren, Robinson, William, Newson, Joshua, Stevens, Anne, Shoop, Stephanie J. W., Verstappen, Suzanne M. M., Thomson, Wendy, McDonagh, Janet E., Beukelman, Timothy, Kimura, Yuki, Natter, Marc, Ilowite, Norm, Mieszkalski, Kelly, Burrell, Grendel, Best, Brian, Bristow, Helen, Carr, Shannon, Dennos, Anne, Kaufmann, Rachel, Schanberg, Laura, Simonini, Gabriele, Lancini, Francesca, Gerbaux, Margaux, Lê, Phu-Quoc, Goffin, Laurence, Badot, Valérie, La, Céline, Caspers, Laure, Willermain, François, Ferster, Alina, Ceci, Maria, Licciardi, Francesco, Turco, Marco, Santarelli, Francesca, Montin, Davide, Toppino, Claudia, Alizzi, Clotilde, Papia, Bruno, Vergara, Beatrice, Corpora, Umberto, Messina, Luca, Tsinti, Maria, Dermentzoglou, Vasiliko, Tziavas, Panagiotis, Perica, Marija, Bukovac, Lana Tambić, Çakan, Mustafa, Ayaz, Nuray Aktay, Keskindemirci, Gonca, Lang, Michael, Laing, Catherine, Benseler, Susanne, Gerschman, Tommy, Luca, Nadia, Schmeling, Heinrike, Dropol, Anastasia, Taiani, Jaymi, Johnson, Nicole, Rusted, Brian, Nalbanti, Panagiota, Pratsidou, Polyxeni, Pardalos, Grigoris, Tzimouli, Vasiliki, Taparkou, Anna, Stavrakidou, Maria, Papachristou, Fotios, Kanakoudi-Tsakalidou, Florence, Bale, Peter, Robinson, Emily, Palman, Jason, Ralph, Elizabeth, Gilmour, Kimberly, Heard, Clare, Wedderburn, Lucy R., Barrense-Dias, Yara, Gregory, Antonarakis, Amira, Dhouib, Paolo, Scolozzi, Sylviane, Hanquinet, Michaël, Hofer, Panko, Nataliya, Shokry, Salah, Rakovska, Liudmila, Pino, Sally, Diaz-Maldonado, Adriana, Guarnizo, Pilar, Torreggiani, Sofia, Cressoni, Paolo, Garagiola, Umberto, Di Landro, Giancarla, Farronato, Giampietro, Corona, Fabrizia, Bell, Samantha, Bhatti, Parveen, Nelson, Lee, Mueller, Beth A., Simon, T. A., Baheti, A., Ray, N., Guo, Z., Hazra, Anasuya, Stock, Thomas, Wang, Ronnie, Mebus, Charles, Alvey, Christine, Lamba, Manisha, Krishnaswami, Sriram, Conte, Umberto, Wang, Min, Kingsbury, Daniel, Koskova, Elena, Smolewska, Elzbieta, Vehe, Richard K., Lovell, Daniel, Kubota, Tomohiro, Yasumura, Junko, Kizawa, Toshitaka, Yashiro, Masato, Yamatou, Tsuyoshi, Yamasaki, Yuichi, Takei, Syuji, Kawano, Yoshifumi, Nykvist, Ulrika Järpemo, Magnusson, Bo, Wicksell, Rikard, Palmblad, Karin, Olsson, Gunnar L., Modaressi, Mohammadreza, Moradinejad, Mohammad-Hassan, Seraya, Valentina, Vitebskaya, Alisa, Moshe, Veronica, Amarilyo, Gil, Harel, Liora, Hashkes, Phillip J, Mendelson, Amir, Rabinowicz, Noa, Reis, Yonit, Dāvidsone, Zane, Lazareva, Arina, Šantere, Ruta, Bērziņa, Dace, Staņēviča, Valda, Varnier, Giulia Camilla, Maillard, Susan, Ferrari, Cristina, Zaffarano, Silvia, Wienke, Judith, Enders, Felicitas Bellutti, van den Hoogen, Lucas L., Mertens, Jorre S., Radstake, Timothy R., Hotten, Henny G., Fritsch, Ruth, Wedderburn, Lucy, Nistala, Kiran, Prakken, Berent, van Royen-Kerkhof, Annet, Alhemairi, Mohammad, Muzaffer, Mohammed, Van Dijkhuizen, Pieter, Deakin, Claire T., Simou, Stefania, De Iorio, Maria, Wu, Qiong, Amin, Tania, Dossetter, Lee, Campanilho-Marques, Raquel, Deakin, Claire, Pilkington, Clarissa A., Rosina, Silvia, Soponkanaporn, Sirisucha, Arıcı, Zehra S., Tuğcu, Gökçen D., Batu, Ezgi D., Sönmez, Hafize E., Doğru-Ersöz, Deniz, Talim, Beril, Kiper, Nural, Özen, Seza, Solyom, Alexander, Batu, Ezgi, Mitchell, John, Kariminejad, Ariana, Hadipour, Fatemeh, Hadipour, Zahra, Torcoletti, Marta, Agostoni, Carlo, Di Rocco, Maja, Tanpaiboon, Pranoot, Superti-Furga, Andrea, Bonafé, Luisa, Arslan, Nur, Guelbert, Norberto, Ehlert, Karoline, Grigelioniene, Giedre, Puri, Ratna, Schuchman, Edward, Gomez, Pilar, Gonzalez, Tatiana, Yepez, Ricardo, Vargas, Camilo, Fernanda, Falcini, Lepri, Gemma, Ferrari, Alessandra, Matucci-Cerinic, Marco, Meini, Antonella, Moneta, Gian Marco, Marasco, Emiliano, Nicolai, Rebecca, Bracci-Laudiero, Luisa, Kopchak, Olga, Mushkin, Alexander, Maletin, Alexey, Mosquera, Catalina, Amorim, Rita A., Molina, Juliana, Moreira, Gustavo, Santos, Flávia H., Fraga, Melissa, Keppeke, Livia, Silva, Vanessa M., Hirotsu, Camila, Tufik, Sergio, Terreri, Maria Teresa, Braga, Vinícius L., Fonseca, Maria Beatriz, Schinzel, Vania, Terreri, Maria Teresa R., Jorge, Liliana, Guerra, Liana, Junior, Edson Amaro, Castiglione, Maria Cristina, Tricarico, Alessandra, Boulter, Emily, Schultz, Andre, Murray, Kevin, Falcini, Fernanda, Stagi, Stefano, Bellucci, Eleonora, Grein, Ingrid H. R., Pileggi, Gecilmara, Pinto, Natália B. F., de Oliveira, Aline L., Belyaeva, Lyudmila, Filonovich, Rostislav, Khrustaleva, Helena, Zajtseva, Larisa, Ilisson, Jaanika, Pruunsild, Chris, Gilliaux, Olivier, Corazza, Francis, Lelubre, Christophe, Morel, Zoilo, C, Claudia Saad-Magalhães, Lira, Luis, Ladino, Mabel, Eraso, Ruth, Arroyo, Ivonne, Silva, Clovis, and Rose, Carlos
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- 2017
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28. Interferon-gamma (IFN gamma) in Macrophage Activation Syndrome (MAS) Associated with Systemic Juvenile Idiopathic Arthritis (sJIA). High Levels in Patients and a Role in a Murine MAS Model
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Bracaglia, Claudia, Caiello, Ivan, Graaf, Kathy, D Ario, Giovanni, Guilhot, Florence, Ferlin, Walter, Meli, Lidia, Giusi Prencipe, Davi, Sergio, Schulert, Grant, Ravelli, Angelo, Grom, Alexei, Min, Cristina, and Benedetti, Fabrizio
29. CC chemokine CCL5 plays a central role impacting infarct size and post-infarction heart failure in mice
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Montecucco, Fabrizio, Braunersreuther, Vincent, Lenglet, Sébastien, Delattre, Benedicte M.A., Pelli, Graziano, Buatois, Vanessa, Guilhot, Florence, Galan, Katia, Vuilleumier, Nicolas, Ferlin, Walter, Fischer, Nicolas, Vallée, Jean-Paul, Kosco-Vilbois, Marie, Mach, François, Montecucco, Fabrizio, Braunersreuther, Vincent, Lenglet, Sébastien, Delattre, Benedicte M.A., Pelli, Graziano, Buatois, Vanessa, Guilhot, Florence, Galan, Katia, Vuilleumier, Nicolas, Ferlin, Walter, Fischer, Nicolas, Vallée, Jean-Paul, Kosco-Vilbois, Marie, and Mach, François
- Abstract
Aims The chemokine CCL5 plays a critical role as neutrophil and macrophage activator do in atherosclerosis and myocardial infarction. Thus, we investigated whether the treatment with a neutralizing monoclonal antibody (mAb) to mouse CCL5 would provide therapeutic benefit when provoking a coronary-associated ischaemic event. Methods and Results C57Bl/6 mice were submitted to left coronary artery permanent ligature. Then, various parameters were monitored for up to 21 days. At5 min and 3days after coronary occlusion, mice received one intravenous injection of the rat anti-mouse CCL5 mAb or isotype IgG control. Infarct size was assessed histologically and by measuring serum cardiac troponin I levels. Kinetics of CCL5 tissue expression, leucocyte infiltration, matrix metalloproteinase (MMP) levels, and collagen deposition were histologically assessed. Serum chemokine levels were measured by enzyme-linked immunosorbent assay. Cardiac function and dimensions were assessed by magnetic resonance imaging (MRI). Chronic ischaemia increased both circulating and intracardiac levels of CCL5. At 24 h, treatment with the anti-CCL5 mAb resulted in a smaller infarct size and reduced circulating levels of chemokines. This effect was associated with reduction of neutrophil and macrophage infiltration within the infarcted myocardium. After 3 days of chronic ischaemia, anti-CCL5 mAb treatment reduced cardiac MMP-9. At 7 days, collagen content was significantly lower. At 21 days, neutralizing CCL5 improved mouse survival, cardiac myocyte size, and cardiac function. Conclusion Treatment with anti-CCL5 mAb significantly reduced both infarct size and post-infarction heart failure in a mouse model of chronic cardiac ischaemia. Cardioprotective effects were associated with the reduction of leucocyte recruitment within infarcted hearts
30. Detection of epsilon class switching and IgE synthesis in human B cells.
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Pène J, Guilhot F, Cognet I, Guglielmi P, Guay-Giroux A, Bonnefoy JY, Elson GC, Yssel H, and Gauchat JF
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- B-Lymphocytes cytology, CD40 Antigens immunology, CD40 Ligand immunology, Cells, Cultured, Culture Techniques, DNA, Circular metabolism, Enzyme-Linked Immunosorbent Assay methods, Fetal Blood cytology, Humans, Immunoglobulin E genetics, Immunoglobulin epsilon-Chains genetics, Immunomagnetic Separation methods, Lymphocyte Activation, Palatine Tonsil cytology, Palatine Tonsil immunology, Spleen cytology, Spleen immunology, B-Lymphocytes immunology, Immunoglobulin Class Switching, Immunoglobulin E immunology, Immunoglobulin epsilon-Chains immunology
- Abstract
We observed that mast cells, as other cells expressing the CD40 ligand CD154, can trigger IgE synthesis in B cells in the presence of interleukin (IL)-4. Numerous complementary techniques can be used to follow the succession of molecular events leading to IgE synthesis. This chapter will illustrate how human B cells (naïve or memory) can be purified, stored, and cultivated in medium that is permissive for IgE synthesis and stimulated with IL-4 or IL-13 and CD40 activation, the latter being induced by soluble CD154, anti-CD40 antibodies, or CD154-expressing cells. All these molecules are expressed by mast cells. The quantification of the epsilon-sterile transcript synthesis by polymerase chain reaction or Northern blot, the epsilon excision circles produced during immunoglobulin heavy chain locus rearrangement by polymerase chain reaction, and the IgE production by enzyme-linked immunosorbent assay will be described.
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- 2006
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31. Expression of biologically active mouse ciliary neutrophic factor (CNTF) and soluble CNTFRalpha in Escherichia coli and characterization of their functional specificities.
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Cognet I, Guilhot F, Chevalier S, Guay-Giroux A, Bert A, Elson GC, Gascan H, and Gauchat JF
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- Animals, Base Sequence, Ciliary Neurotrophic Factor isolation & purification, DNA Primers, Electrophoresis, Polyacrylamide Gel, Leukemia, Myeloid metabolism, Leukemia, Myeloid pathology, Mice, Receptor, Ciliary Neurotrophic Factor isolation & purification, Recombinant Proteins genetics, Recombinant Proteins isolation & purification, Recombinant Proteins metabolism, Ciliary Neurotrophic Factor genetics, Ciliary Neurotrophic Factor metabolism, Escherichia coli genetics, Receptor, Ciliary Neurotrophic Factor genetics, Receptor, Ciliary Neurotrophic Factor metabolism
- Abstract
Ciliary neurotrophic factor (CNTF) is a neuroprotective cytokine initially identified in chick embryo. It has been evaluated for the treatment of neurodegenerative diseases. CNTF also acts on non-neuronal cells such as oligodendrocytes, astrocytes, adipocytes and skeletal muscles cells. CNTF has regulatory effects on body weight and is currently in clinical trial for the treatment of diabetes and obesity. CNTF mediates its function by activating a tripartite receptor comprising the CNTF receptor alpha chain (CNTFRalpha), the leukemia inhibitory factor receptor beta chain (LIFRbeta) and gp130. Human, rat and chicken CNTF have been expressed as recombinant proteins, and most preclinical studies in murine models have been performed using rat recombinant protein. Rat and human CNTF differ in their fine specificities: in addition to CNTFR, rat CNTF has been shown to activate the LIFR (a heterodimer of LIFRbeta and gp130), whereas human CNTF can bind and activate a tripartite receptor comprising the IL-6 receptor alpha chain (IL-6Ralpha) and LIFR. To generate tools designed for mouse models of human diseases; we cloned and expressed in E. coli both mouse CNTF and the CNTFRalpha chain. Recombinant mouse CNTF was active and showed a high level of specificity for mouse CNTFR. It shares the arginine residue with rat CNTF which prevents binding to IL-6Ralpha. It did not activate the LIFR at all concentrations tested. Recombinant mouse CNTF is therefore specific for CNTFR and as such represents a useful tool with which to study CNTF in mouse models. It appears well suited for the comparative evaluation of CNTF and the two additional recently discovered CNTFR ligands, cardiotrophin-like cytokine\cytokine-like factor-1 and neuropoietin.
- Published
- 2004
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