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3 results on '"Guilherme Caneppele, Paveglio"'

1. Synthesis of N-phenyl- and N-thiazolyl-1H-indazoles by copper-catalyzed intramolecular N-arylation of ortho-chlorinated arylhydrazones

Author

Yara Cristina Marchioro Barbosa, Guilherme Caneppele Paveglio, Claudio Martin Pereira de Pereira, Sidnei Moura, Cristiane Storck Schwalm, Gleison Antonio Casagrande, and Lucas Pizzuti

Subjects
fused-ring systems, hydrazones, indazoles, intramolecular cyclization, n-heterocycles, Science, Organic chemistry, QD241-441
Abstract

The broad application of 1H-indazoles has prompted the development of several approaches for the synthesis of such compounds, including metal-free, palladium-, or copper-promoted intramolecular N-arylation of in situ-generated or isolated o-haloarylhydrazones. Such methods mainly start from o-bromo derivatives due to the better yield observed when compared to those obtained from o-chloroarylhydrazones. However, the o-chloroarylaldehydes and o-chloroarylketones used to prepare the arylhydrazones are more commercially available and less expensive than brominated analogs. Seeking to cover a lack in the literature, this work reports a convenient protocol for the synthesis of N-phenyl- and N-thiazolyl-1H-indazoles by copper-catalyzed intramolecular N-arylation of o-chlorinated arylhydrazones. Therefore, a series of seven N-phenyl derivatives and a series of six novel N-thiazolyl derivatives was obtained in 10–70% and 12–35% yield, respectively, after stirring the o-chlorinated arylhydrazones, CuI, KOH, and 1,10-phenantroline for 12–48 hours in DMF at 120 °C. The products were isolated by column chromatography on silica gel. All products were fully characterized by HRMS as well as 1H and 13C NMR spectroscopy. Thus, this approach is valuable for promoting the synthesis of N-phenyl-1H-indazoles in a higher yield than that reported in the literature using copper catalysis and the same substrates. This study also prompted the first reported synthesis of pharmacologically interesting N-thiazolyl derivatives.

Published
2022
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2. Synthesis of

Author

Yara Cristina Marchioro, Barbosa, Guilherme Caneppele, Paveglio, Claudio Martin Pereira, de Pereira, Sidnei, Moura, Cristiane Storck, Schwalm, Gleison Antonio, Casagrande, and Lucas, Pizzuti

Abstract

The broad application of 1

Published
2022

3. Narrowing the interface between sample preparation and electrochemistry: Trace-level determination of emerging pollutant in water samples after in situ microextraction and electroanalysis using a new cell configuration

Author

Jéssica Vita Gabbana, Luiz Henrique de Oliveira, Magno Aparecido Gonçalves Trindade, Guilherme Caneppele Paveglio, Universidade Federal da Grande Dourados, State University of Mato Grosso do Sul, and Universidade Estadual Paulista (Unesp)

Subjects
Green chemistry, Analyte, Materials science, General Chemical Engineering, Drop (liquid), 010401 analytical chemistry, Analytical chemistry, Residual drugs determination, 02 engineering and technology, 021001 nanoscience & nanotechnology, Electrochemistry, 01 natural sciences, Electroanalysis at trace-level, 0104 chemical sciences, Deep eutectic solvent, Solvent, chemistry.chemical_compound, chemistry, Electrode, In situ microextraction, Sample preparation, Contaminant of emerging concern, 0210 nano-technology
Abstract

Made available in DSpace on 2018-12-11T16:53:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-06-10 Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul In this work, a new cell configuration that enables the in situ integration of sample preparation and electrochemical detection prior analysis at trace-level is described. To perform the microextraction, a green chemistry extractor solvent, so called deep eutectic solvent (DES) was used, which allowed the pre-concentration of ciprofloxacin (CIPRO) from water samples. The particular characteristics of the featured device include: reduction of the number of steps involved in conventional liquid-liquid microextraction, processing the pre-concentration of target analyte in a small drop that can be directly decanted onto the electrode surface and further electroanalysis at a single time in order to achieve the required trace-level quantity. After the optimization of parameters inherent to the system, with the aid of chemometric approach, the proposed device enabled fast electroanalysis of CIPRO at concentration levels down to 5.00 nmol L−1 with suitable accuracy, since the recovery values were ranged between 71 and 93%. Faculdade de Ciências Exatas e Tecnologia Universidade Federal da Grande Dourados, Rodovia Dourados-Itahum, km 12 State University of Mato Grosso do Sul, Rodovia Dourados-Itahum, km 12 Unesp National Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM) Institute of Chemistry, P.O. Box 355 Unesp National Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM) Institute of Chemistry, P.O. Box 355 CNPq: 23/200.258/2014 CAPES: 88881.119436/2016-01

Published
2018
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