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249 results on '"Guilfoyle, Mathew R."'

5. Reduced temporal muscle thickness predicts shorter survival in patients undergoing chronic subdural haematoma drainage

Author

Korhonen, Tommi K., primary, Arponen, Otso, additional, Steinruecke, Moritz, additional, Pecorella, Ilaria, additional, Mee, Harry, additional, Yordanov, Stefan, additional, Viaroli, Edoardo, additional, Guilfoyle, Mathew R., additional, Kolias, Angelos, additional, Timofeev, Ivan, additional, Hutchinson, Peter, additional, and Helmy, Adel, additional

Published
2024
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6. A map of transcriptional heterogeneity and regulatory variation in human microglia

Author

Young, Adam M. H., Kumasaka, Natsuhiko, Calvert, Fiona, Hammond, Timothy R., Knights, Andrew, Panousis, Nikolaos, Park, Jun Sung, Schwartzentruber, Jeremy, Liu, Jimmy, Kundu, Kousik, Segel, Michael, Murphy, Natalia A., McMurran, Christopher E., Bulstrode, Harry, Correia, Jason, Budohoski, Karol P., Joannides, Alexis, Guilfoyle, Mathew R., Trivedi, Rikin, Kirollos, Ramez, Morris, Robert, Garnett, Matthew R., Timofeev, Ivan, Jalloh, Ibrahim, Holland, Katherine, Mannion, Richard, Mair, Richard, Watts, Colin, Price, Stephen J., Kirkpatrick, Peter J., Santarius, Thomas, Mountjoy, Edward, Ghoussaini, Maya, Soranzo, Nicole, Bayraktar, Omer A., Stevens, Beth, Hutchinson, Peter J., Franklin, Robin J. M., and Gaffney, Daniel J.

Published
2021
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11. Focally administered succinate improves cerebral metabolism in traumatic brain injury patients with mitochondrial dysfunction

Author

Khellaf, Abdelhakim, Garcia, Nuria Marco, Tajsic, Tamara, Alam, Aftab, Stovell, Matthew G, Killen, Monica J, Howe, Duncan J, Guilfoyle, Mathew R, Jalloh, Ibrahim, Timofeev, Ivan, Murphy, Michael P, Carpenter, T Adrian, Menon, David K, Ercole, Ari, Hutchinson, Peter J, Carpenter, Keri LH, Thelin, Eric P, and Helmy, Adel

Published
2022
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14. What Factors Determine Treatment Outcome in Aneurysmal Subarachnoid Hemorrhage in the Modern Era? A Post Hoc STASH Analysis

Author

Kirkpatrick, Peter J., Turner, Carole L., Murray, Gordon D., Hutchinson, Peter J., Teasdale, Graham, Mendelow, A. David, Muir, Keith, Smith, Martin, McCabe, Peter, Pearson, Jeremy, Ford, Gary, Vail, Andrew, King, Andrew, Tyrrell, Pippa, Richards, Hugh, Bond, Simon, Smith, Christopher, Warburton, Elizabeth, Tseng, Ming, Bulters, Diederik, Brown, Martina, Critchley, Giles, Spurling, Gavin, Gaylard, Jane, Javadpour, Mohsen, Eldridge, Paul, Murray, Lorna, Nelson, Richard, Taylor, Ros, Hierons, Sarah, Tobin, Bianca, Storey, Kelley, Walsh, Daniel, Mistry, Bejal, Aeron-Thomas, John, Puppo, Corina, Papadopoulos, Mario, Montague, Laura, Gan, Peter, Flint, Graham, Hurley, Jennie, Ronne, Elizabeth, Stjernling, Inger, Wang, Ernest, Leen Cheng, Ei, Lai, Jing Li, Ross, Stuart, Bellfield, Ruth, Mandizvidza, Linetty, Whitfield, Peter, Persad, Nicola, Suttner, Nigel, Teo, Mario, McGuigan, Kate, Cloughley, Linda, Patel, Hiren, Ingham, Andrea, Shaw, Kellymarie, Vindlacheruvu, Raghu, Millo, Julian, Warner, Orlando, Teal, Rachel, Bernard, Francis, Sirois, Carol, Joshi, Shaban, Nyabadza, Sheila, Grieve, Joan, Kitchen, Neil, Bassan, Vanessa, Rayson, Philip, Zeitlin, Alexander, Findlay, Max, Sonnema, Leeca, Poworoznik, Brenda, Quintero, Juan, Eljamel, Sam, Rasulo, Frank, Ng, Ivan, Mathew, Bruce, Grieg, Jill, Hanel, Ricardo, Richie, Alexa, Fleetwood, Ian, Reardon-White, Elizabeth, Hampton, Ginger, Lewis, Stephen, Miralia, Lynn, Brydon, Howard, Maguire, Holly, Patel, Umang, Sanderson, Helen, Birchall, Kathryn, Bayliss, Pauline, O'Neill, Kevin, Sachs, Tina, Kett-White, Rupert, Quinn, Leanne, Guilfoyle, Mathew R., and Turner, Carole

Published
2017
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19. Brain tissue oxygen monitoring in traumatic brain injury - part II : isolated and combined insults in relation to outcome

Author

Svedung-Wettervik, Teodor, Beqiri, Erta, Hånell, Anders, Bögli, Stefan Yu, Placek, Michal, Guilfoyle, Mathew R., Helmy, Adel, Lavinio, Andrea, O'Leary, Ronan, Hutchinson, Peter J., Smielewski, Peter, Svedung-Wettervik, Teodor, Beqiri, Erta, Hånell, Anders, Bögli, Stefan Yu, Placek, Michal, Guilfoyle, Mathew R., Helmy, Adel, Lavinio, Andrea, O'Leary, Ronan, Hutchinson, Peter J., and Smielewski, Peter

Abstract

Background: The primary aim was to explore the concept of isolated and combined threshold-insults for brain tissue oxygenation (pbtO(2)) in relation to outcome in traumatic brain injury (TBI). Methods: A total of 239 TBI patients with data on clinical outcome (GOS) and intracranial pressure (ICP) and pbtO(2) monitoring for at least 12 h, who had been treated at the neurocritical care unit, Addenbrooke's Hospital, Cambridge, UK, between 2002 and 2022 were included. Outcome was dichotomised into favourable/unfavourable (GOS 4-5/1-3) and survival/mortality (GOS 2-5/1). PbtO(2) was studied over the entire monitoring period. Thresholds were analysed in relation to outcome based on median and mean values, percentage of time and dose per hour below critical values and visualised as the combined insult intensity and duration. Results: Median pbtO(2) was slightly, but not significantly, associated with outcome. A pbtO(2) threshold at 25 and 20 mmHg, respectively, yielded the highest x(2) when dichotomised for favourable/unfavourable outcome and mortality/survival in chi-square analyses. A higher dose and higher percentage of time spent with pbtO(2) below 25 mmHg as well as lower thresholds were associated with unfavourable outcome, but not mortality. In a combined insult intensity and duration analysis, there was a transition from favourable towards unfavourable outcome when pbtO(2) went below 25-30 mmHg for 30 min and similar transitions occurred for shorter durations when the intensity was higher. Although these insults were rare, pbtO(2) under 15 mmHg was more strongly associated with unfavourable outcome if, concurrently, ICP was above 20 mmHg, cerebral perfusion pressure below 60 mmHg, or pressure reactivity index above 0.30 than if these variables were not deranged. In a multiple logistic regression, a higher percentage of monitoring time with pbtO(2) < 15 mmHg was associated with a higher rate of unfavourable outcome. Conclusions: Low pbtO(2), under 25 mmHg and par

Published
2023
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20. Brain tissue oxygen monitoring in traumatic brain injury : part I-To what extent does PbtO(2) reflect global cerebral physiology?

Author

Svedung-Wettervik, Teodor, Beqiri, Erta, Boegli, Stefan Yu, Placek, Michal, Guilfoyle, Mathew R., Helmy, Adel, Lavinio, Andrea, O'Leary, Ronan, Hutchinson, Peter J., Smielewski, Peter, Svedung-Wettervik, Teodor, Beqiri, Erta, Boegli, Stefan Yu, Placek, Michal, Guilfoyle, Mathew R., Helmy, Adel, Lavinio, Andrea, O'Leary, Ronan, Hutchinson, Peter J., and Smielewski, Peter

Abstract

Background The primary aim was to explore the association of global cerebral physiological variables including intracranial pressure (ICP), cerebrovascular reactivity (PRx), cerebral perfusion pressure (CPP), and deviation from the PRx-based optimal CPP value ( increment CPPopt; actual CPP-CPPopt) in relation to brain tissue oxygenation (pbtO2) in traumatic brain injury (TBI). Methods A total of 425 TBI patients with ICP- and pbtO2 monitoring for at least 12 h, who had been treated at the neurocritical care unit, Addenbrooke's Hospital, Cambridge, UK, between 2002 and 2022 were included. Generalized additive models (GAMs) and linear mixed effect models were used to explore the association of ICP, PRx, CPP, and CPPopt in relation to pbtO(2.) PbtO(2) < 20 mmHg, ICP > 20 mmHg, PRx > 0.30, CPP < 60 mmHg, and increment CPPopt < - 5 mmHg were considered as cerebral insults. Results PbtO(2) < 20 mmHg occurred in median during 17% of the monitoring time and in less than 5% in combination with ICP > 20 mmHg, PRx > 0.30, CPP < 60 mmHg, or increment CPPopt < - 5 mmHg. In GAM analyses, pbtO(2 )remained around 25 mmHg over a large range of ICP ([0;50] mmHg) and PRx [- 1;1], but deteriorated below 20 mmHg for extremely low CPP below 30 mmHg and increment CPPopt below - 30 mmHg. In linear mixed effect models, ICP, CPP, PRx, and increment CPPopt were significantly associated with pbtO(2), but the fixed effects could only explain a very small extent of the pbtO(2) variation. Conclusions PbtO(2 )below 20 mmHg was relatively frequent and often occurred in the absence of disturbances in ICP, PRx, CPP, and increment CPPopt. There were significant, but weak associations between the global cerebral physiological variables and pbtO(2), suggesting that hypoxic pbtO2 is often a complex and independent pathophysiological event. Thus, other variables may be more crucial to explain pbtO(2) and, likewise, pbtO2 may not be a suitable outcome measure to determine whet

Published
2023
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22. High-physiological and supra-physiological 1,2- 13 C2 glucose focal supplementation to the traumatised human brain.

Author

Stovell, Matthew G, Howe, Duncan J, Thelin, Eric P, Jalloh, Ibrahim, Helmy, Adel, Guilfoyle, Mathew R, Grice, Peter, Mason, Andrew, Giorgi-Coll, Susan, Gallagher, Clare N, Murphy, Michael P, Menon, David K, Carpenter, T Adrian, Hutchinson, Peter J, and Carpenter, Keri LH

Abstract

How to optimise glucose metabolism in the traumatised human brain remains unclear, including whether injured brain can metabolise additional glucose when supplied. We studied the effect of microdialysis-delivered 1,2-13C2 glucose at 4 and 8 mmol/L on brain extracellular chemistry using bedside ISCUS flex, and the fate of the 13C label in the 8 mmol/L group using high-resolution NMR of recovered microdialysates, in 20 patients. Compared with unsupplemented perfusion, 4 mmol/L glucose increased extracellular concentrations of pyruvate (17%, p = 0.04) and lactate (19%, p = 0.01), with a small increase in lactate/pyruvate ratio (5%, p = 0.007). Perfusion with 8 mmol/L glucose did not significantly influence extracellular chemistry measured with ISCUS flex, compared to unsupplemented perfusion. These extracellular chemistry changes appeared influenced by the underlying metabolic states of patients' traumatised brains, and the presence of relative neuroglycopaenia. Despite abundant 13C glucose supplementation, NMR revealed only 16.7% 13C enrichment of recovered extracellular lactate; the majority being glycolytic in origin. Furthermore, no 13C enrichment of TCA cycle-derived extracellular glutamine was detected. These findings indicate that a large proportion of extracellular lactate does not originate from local glucose metabolism, and taken together with our earlier studies, suggest that extracellular lactate is an important transitional step in the brain's production of glutamine. [ABSTRACT FROM AUTHOR]

Published
2023
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24. Comparison of health-related quality of life in patients with traumatic brain injury, subarachnoid haemorrhage and cervical spine disease

Author

Tsyben, Anastasia, primary, Guilfoyle, Mathew R., additional, Laing, Rodney J. C., additional, Timofeev, Ivan, additional, Anwar, Fahim, additional, Trivedi, Rikin A., additional, Kirollos, Ramez W., additional, Turner, Carole, additional, Allanson, Judith, additional, Mee, Harry, additional, Outtrim, Joanne G., additional, Menon, David K., additional, Hutchinson, Peter J. A., additional, and Helmy, Adel, additional

Published
2022
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25. sj-pdf-1-jcb-10.1177_0271678X231173584 - Supplemental material for High-physiological and supra-physiological 1,2-13C2 glucose focal supplementation to the traumatised human brain

Author

Stovell, Matthew G, Howe, Duncan J, Thelin, Eric P, Jalloh, Ibrahim, Helmy, Adel, Guilfoyle, Mathew R, Grice, Peter, Mason, Andrew, Giorgi-Coll, Susan, Gallagher, Clare N, Murphy, Michael P, Menon, David K, Carpenter, T Adrian, Hutchinson, Peter J, and Carpenter, Keri LH

Subjects
110320 Radiology and Organ Imaging, FOS: Clinical medicine, FOS: Biological sciences, Medicine, Cell Biology, 110305 Emergency Medicine, 110306 Endocrinology, Biochemistry, 69999 Biological Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-pdf-1-jcb-10.1177_0271678X231173584 for High-physiological and supra-physiological 1,2-13C2 glucose focal supplementation to the traumatised human brain by Matthew G Stovell, Duncan J Howe, Eric P Thelin, Ibrahim Jalloh, Adel Helmy, Mathew R Guilfoyle, Peter Grice, Andrew Mason, Susan Giorgi-Coll, Clare N Gallagher, Michael P Murphy, David K Menon, T Adrian Carpenter, Peter J Hutchinson and Keri LH Carpenter in Journal of Cerebral Blood Flow & Metabolism

Published
2023
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29. Brain tissue oxygen monitoring in traumatic brain injury: part I—To what extent does PbtO2 reflect global cerebral physiology?

Author

Svedung Wettervik, Teodor, Beqiri, Erta, Bögli, Stefan Yu, Placek, Michal, Guilfoyle, Mathew R., Helmy, Adel, Lavinio, Andrea, O'Leary, Ronan, Hutchinson, Peter J., and Smielewski, Peter

Abstract

Background: The primary aim was to explore the association of global cerebral physiological variables including intracranial pressure (ICP), cerebrovascular reactivity (PRx), cerebral perfusion pressure (CPP), and deviation from the PRx-based optimal CPP value (∆CPPopt; actual CPP-CPPopt) in relation to brain tissue oxygenation (pbtO2) in traumatic brain injury (TBI). Methods: A total of 425 TBI patients with ICP- and pbtO2 monitoring for at least 12 h, who had been treated at the neurocritical care unit, Addenbrooke's Hospital, Cambridge, UK, between 2002 and 2022 were included. Generalized additive models (GAMs) and linear mixed effect models were used to explore the association of ICP, PRx, CPP, and CPPopt in relation to pbtO2. PbtO2 < 20 mmHg, ICP > 20 mmHg, PRx > 0.30, CPP < 60 mmHg, and ∆CPPopt < − 5 mmHg were considered as cerebral insults. Results: PbtO2 < 20 mmHg occurred in median during 17% of the monitoring time and in less than 5% in combination with ICP > 20 mmHg, PRx > 0.30, CPP < 60 mmHg, or ∆CPPopt < − 5 mmHg. In GAM analyses, pbtO2 remained around 25 mmHg over a large range of ICP ([0;50] mmHg) and PRx [− 1;1], but deteriorated below 20 mmHg for extremely low CPP below 30 mmHg and ∆CPPopt below − 30 mmHg. In linear mixed effect models, ICP, CPP, PRx, and ∆CPPopt were significantly associated with pbtO2, but the fixed effects could only explain a very small extent of the pbtO2 variation. Conclusions: PbtO2 below 20 mmHg was relatively frequent and often occurred in the absence of disturbances in ICP, PRx, CPP, and ∆CPPopt. There were significant, but weak associations between the global cerebral physiological variables and pbtO2, suggesting that hypoxic pbtO2 is often a complex and independent pathophysiological event. Thus, other variables may be more crucial to explain pbtO2 and, likewise, pbtO2 may not be a suitable outcome measure to determine whether global cerebral blood flow optimization such as CPPopt therapy is successful. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Characterising the dynamics of cerebral metabolic dysfunction following traumatic brain injury: A microdialysis study in 619 patients

Author

Guilfoyle, Mathew R., primary, Helmy, Adel, additional, Donnelly, Joseph, additional, Stovell, Matthew G., additional, Timofeev, Ivan, additional, Pickard, John D., additional, Czosnyka, Marek, additional, Smielewski, Peter, additional, Menon, David K., additional, Carpenter, Keri L. H., additional, and Hutchinson, Peter J., additional

Published
2021
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35. Longitudinal Changes in Size of Conservatively Managed Flow-Related Aneurysms Associated with Brain Arteriovenous Malformations

Author

Budohoski, Karol P., primary, Mohan, Midhun, additional, Millar, Zack, additional, Tajsic, Tamara, additional, Barone, Damiano G., additional, Cao, Jennifer J.L., additional, Mediratta, Saniya, additional, Phelps, Ellie, additional, Sukthankar, Tanmay, additional, Kirollos, Ramez W., additional, Helmy, Adel E., additional, Guilfoyle, Mathew R., additional, and Trivedi, Rikin A., additional

Published
2021
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36. Focally administered succinate improves cerebral metabolism in traumatic brain injury patients with mitochondrial dysfunction

Author

Khellaf, Abdelhakim, primary, Garcia, Nuria Marco, additional, Tajsic, Tamara, additional, Alam, Aftab, additional, Stovell, Matthew G, additional, Killen, Monica J, additional, Howe, Duncan J, additional, Guilfoyle, Mathew R, additional, Jalloh, Ibrahim, additional, Timofeev, Ivan, additional, Murphy, Michael P, additional, Carpenter, T Adrian, additional, Menon, David K, additional, Ercole, Ari, additional, Hutchinson, Peter J, additional, Carpenter, Keri LH, additional, Thelin, Eric P, additional, and Helmy, Adel, additional

Published
2021
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38. Additional file 2 of Systemic inflammation alters the neuroinflammatory response: a prospective clinical trial in traumatic brain injury

Author

Lassarén, Philipp, Lindblad, Caroline, Frostell, Arvid, Carpenter, Keri L. H., Guilfoyle, Mathew R., Hutchinson, Peter J. A., Helmy, Adel, and Thelin, Eric Peter

Abstract

Additional file 2. Title of data: Code. Description of data: Code for generating all figures and tables provided. Order of appearance: Figures 1-5, Tables 1-2, Additional file 6-7. Additional file 5 is generated by code for Figures 3-4.

Published
2021
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39. Additional file 1 of Systemic inflammation alters the neuroinflammatory response: a prospective clinical trial in traumatic brain injury

Author

Lassarén, Philipp, Lindblad, Caroline, Frostell, Arvid, Carpenter, Keri L. H., Guilfoyle, Mathew R., Hutchinson, Peter J. A., Helmy, Adel, and Thelin, Eric Peter

Abstract

Additional file 1. Title of data: Baseline data. Description of data: Columns for the first eight rows are for each patient (C, control; I, intervention); moreover, the first four rows have time along the horizontal axis. Columns for the final row are for each cytokine. Rows 1-3 display changes over time of white cell count (WCC), C-reactive protein (CRP) and temperature, with corresponding lines of best fit. Row 4 displays infection status of patients over time. Row 5 shows infection (VAP, ventilator-associated pneumonia; IAS intra-abdominal sepsis; CI, chest infection), severe adverse events (SAE), sex (M, male; F, female) and years of age for each patient. Row 6 shows Stockholm computed tomography (CT) score for each patient, coloured after whether a deterioration was observed during hospital stay. Row 7 shows injury severity score (ISS) for each patient. Row 8 shows fraction of missingness in each compartment and for each patient. Row 9 shows fraction of missing cytokines in each compartment. The chest infection was a result of mucous plugging resulting in a right lower lobe collapse, hence not fulfilling VAP criteria.

Published
2021
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41. sj-pdf-1-jcb-10.1177_0271678X211042112 - Supplemental material for Focally administered succinate improves cerebral metabolism in traumatic brain injury patients with mitochondrial dysfunction

Author

Khellaf, Abdelhakim, Garcia, Nuria Marco, Tajsic, Tamara, Alam, Aftab, Stovell, Matthew G, Killen, Monica J, Howe, Duncan J, Guilfoyle, Mathew R, Jalloh, Ibrahim, Timofeev, Ivan, Murphy, Michael P, Carpenter, T Adrian, Menon, David K, Ercole, Ari, Hutchinson, Peter J, Carpenter, Keri LH, Thelin, Eric P, and Helmy, Adel

Subjects
110320 Radiology and Organ Imaging, FOS: Clinical medicine, FOS: Biological sciences, Medicine, Cell Biology, 110305 Emergency Medicine, 110306 Endocrinology, Biochemistry, 69999 Biological Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-pdf-1-jcb-10.1177_0271678X211042112 for Focally administered succinate improves cerebral metabolism in traumatic brain injury patients with mitochondrial dysfunction by Abdelhakim Khellaf, Nuria Marco Garcia, Tamara Tajsic, Aftab Alam, Matthew G Stovell, Monica J Killen, Duncan J Howe, Mathew R Guilfoyle, Ibrahim Jalloh, Ivan Timofeev, Michael P Murphy, T Adrian Carpenter, David K Menon, Ari Ercole, Peter J Hutchinson, Keri LH Carpenter, Eric P Thelin and Adel Helmy in Journal of Cerebral Blood Flow & Metabolism

Published
2021
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49. A map of transcriptional heterogeneity and regulatory variation in human microglia

Author

Young, Adam MH, primary, Kumasaka, Natsuhiko, additional, Calvert, Fiona, additional, Hammond, Timothy R., additional, Knights, Andrew, additional, Panousis, Nikolaos, additional, Schwartzentruber, Jeremy, additional, Liu, Jimmy, additional, Kundu, Kousik, additional, Segel, Michael, additional, Murphy, Natalia, additional, McMurran, Christopher E, additional, Bulstrode, Harry, additional, Correia, Jason, additional, Budohoski, Karol P, additional, Joannides, Alexis, additional, Guilfoyle, Mathew R, additional, Trivedi, Rikin, additional, Kirollos, Ramez, additional, Morris, Robert, additional, Garnett, Matthew R, additional, Fernandes, Helen, additional, Timofeev, Ivan, additional, Jalloh, Ibrahim, additional, Holland, Katherine, additional, Mannion, Richard, additional, Mair, Richard, additional, Watts, Colin, additional, Price, Stephen J, additional, Kirkpatrick, Peter J, additional, Santarius, Thomas, additional, Soranzo, Nicole, additional, Stevens, Beth, additional, Hutchinson, Peter J, additional, Franklin, Robin JM, additional, and Gaffney, Daniel J, additional

Published
2019
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