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2. NCCN Working Group report: designing clinical trials in the era of multiple biomarkers and targeted therapies.

Author

Venook, Alan P, Arcila, Maria E, Benson, Al B, Berry, Donald A, Camidge, David Ross, Carlson, Robert W, Choueiri, Toni K, Guild, Valerie, Kalemkerian, Gregory P, Kurzrock, Razelle, Lovly, Christine M, McKee, Amy E, Morgan, Robert J, Olszanski, Anthony J, Redman, Mary W, Stearns, Vered, McClure, Joan, and Birkeland, Marian L

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Clinical Research, Genetics, Clinical Trials and Supportive Activities, 8.4 Research design and methodologies (health services), Health and social care services research, Good Health and Well Being, Biomarkers, Clinical Trials as Topic, Humans, Neoplasms, Precision Medicine, Research Design, Oncology & Carcinogenesis, Oncology and carcinogenesis, Health services and systems
Abstract

Defining treatment-susceptible or -resistant populations of patients with cancer through the use of genetically defined biomarkers has revolutionized cancer care in recent years for some disease/patient groups. Research continues to show that histologically defined diseases are diverse in their expression of unique mutations or other genetic alterations, however, which presents opportunities for the development of personalized cancer treatments, but increased difficulty in testing these therapies, because potential patient populations are divided into ever smaller numbers. To address some of the growing challenges in biomarker development and clinical trial design, NCCN assembled a group of experts across specialties and solid tumor disease types to begin to define the problems and to consider alternate ways of designing clinical trials in the era of multiple biomarkers and targeted therapies. Results from that discussion are presented, focusing on issues of clinical trial design from the perspective of statisticians, clinical researchers, regulators, pathologists, and information developers.

Published
2014

3. Guidelines of care for the management of primary cutaneous melanoma

Author

Swetter, Susan M., Tsao, Hensin, Bichakjian, Christopher K., Curiel-Lewandrowski, Clara, Elder, David E., Gershenwald, Jeffrey E., Guild, Valerie, Grant-Kels, Jane M., Halpern, Allan C., Johnson, Timothy M., Sober, Arthur J., Thompson, John A., Wisco, Oliver J., Wyatt, Samantha, Hu, Shasa, and Lamina, Toyin

Published
2019
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6. Multidisciplinary Expert-Driven Consensus on the Evolving Treatment of Patients with Advanced Cutaneous Squamous Cell Carcinoma

Author

Migden, Michael R, primary, Schlesinger, Todd E, additional, Schmults, Chrysalyne D, additional, Dinehart, Scott M, additional, Ferris, Robert L, additional, Freeman, Morganna, additional, Guild, Valerie, additional, Koyfman, Shlomo, additional, Pavlick, Anna C, additional, Wolf, Gregory T, additional, Rabinowits, Guilherme, additional, and Swanson, Neil, additional

Published
2019
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7. Cutaneous Melanoma, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology

Author

Coit, Daniel G., primary, Thompson, John A., additional, Albertini, Mark R., additional, Barker, Christopher, additional, Carson, William E., additional, Contreras, Carlo, additional, Daniels, Gregory A., additional, DiMaio, Dominick, additional, Fields, Ryan C., additional, Fleming, Martin D., additional, Freeman, Morganna, additional, Galan, Anjela, additional, Gastman, Brian, additional, Guild, Valerie, additional, Johnson, Douglas, additional, Joseph, Richard W., additional, Lange, Julie R., additional, Nath, Sameer, additional, Olszanski, Anthony J., additional, Ott, Patrick, additional, Gupta, Aparna Priyanath, additional, Ross, Merrick I., additional, Salama, April K., additional, Skitzki, Joseph, additional, Sosman, Jeffrey, additional, Swetter, Susan M., additional, Tanabe, Kenneth K., additional, Wuthrick, Evan, additional, McMillian, Nicole R., additional, and Engh, Anita M., additional

Published
2019
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9. NCCN Guidelines Insights: Melanoma, Version 3.2016

Author

Coit, Daniel G., primary, Thompson, John A., additional, Algazi, Alain, additional, Andtbacka, Robert, additional, Bichakjian, Christopher K., additional, Carson, William E., additional, Daniels, Gregory A., additional, DiMaio, Dominick, additional, Fields, Ryan C., additional, Fleming, Martin D., additional, Gastman, Brian, additional, Gonzalez, Rene, additional, Guild, Valerie, additional, Johnson, Douglas, additional, Joseph, Richard W., additional, Lange, Julie R., additional, Martini, Mary C., additional, Materin, Miguel A., additional, Olszanski, Anthony J., additional, Ott, Patrick, additional, Gupta, Aparna Priyanath, additional, Ross, Merrick I., additional, Salama, April K., additional, Skitzki, Joseph, additional, Swetter, Susan M., additional, Tanabe, Kenneth K., additional, Torres-Roca, Javier F., additional, Trisal, Vijay, additional, Urist, Marshall M., additional, McMillian, Nicole, additional, and Engh, Anita, additional

Published
2016
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10. Melanoma, Version 2.2016, NCCN Clinical Practice Guidelines in Oncology

Author

Coit, Daniel G., primary, Thompson, John A., additional, Algazi, Alain, additional, Andtbacka, Robert, additional, Bichakjian, Christopher K., additional, Carson, William E., additional, Daniels, Gregory A., additional, DiMaio, Dominick, additional, Ernstoff, Marc, additional, Fields, Ryan C., additional, Fleming, Martin D., additional, Gonzalez, Rene, additional, Guild, Valerie, additional, Halpern, Allan C., additional, Hodi, F. Stephen, additional, Joseph, Richard W., additional, Lange, Julie R., additional, Martini, Mary C., additional, Materin, Miguel A., additional, Olszanski, Anthony J., additional, Ross, Merrick I., additional, Salama, April K., additional, Skitzki, Joseph, additional, Sosman, Jeff, additional, Swetter, Susan M., additional, Tanabe, Kenneth K., additional, Torres-Roca, Javier F., additional, Trisal, Vijay, additional, Urist, Marshall M., additional, McMillian, Nicole, additional, and Engh, Anita, additional

Published
2016
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11. Melanoma, Version 4.2014

Author

Coit, Daniel G., primary, Thompson, John A., additional, Andtbacka, Robert, additional, Anker, Christopher J., additional, Bichakjian, Christopher K., additional, Carson, William E., additional, Daniels, Gregory A., additional, Daud, Adil, additional, DiMaio, Dominick, additional, Fleming, Martin D., additional, Gonzalez, Rene, additional, Guild, Valerie, additional, Halpern, Allan C., additional, Hodi, F. Stephen, additional, Kelley, Mark C., additional, Khushalani, Nikhil I., additional, Kudchadkar, Ragini R., additional, Lange, Julie R., additional, Martini, Mary C., additional, Olszanski, Anthony J., additional, Ross, Merrick I., additional, Salama, April, additional, Swetter, Susan M., additional, Tanabe, Kenneth K., additional, Trisal, Vijay, additional, Urist, Marshall M., additional, McMillian, Nicole R., additional, and Ho, Maria, additional

Published
2014
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12. Melanoma, Version 2.2013

Author

Coit, Daniel G., primary, Andtbacka, Robert, additional, Anker, Christopher J., additional, Bichakjian, Christopher K., additional, Carson, William E., additional, Daud, Adil, additional, DiMaio, Dominick, additional, Fleming, Martin D., additional, Guild, Valerie, additional, Halpern, Allan C., additional, Hodi, F. Stephen, additional, Kelley, Mark C., additional, Khushalani, Nikhil I., additional, Kudchadkar, Ragini R., additional, Lange, Julie R., additional, Lind, Anne, additional, Martini, Mary C., additional, Olszanski, Anthony J., additional, Pruitt, Scott K., additional, Ross, Merrick I., additional, Swetter, Susan M., additional, Tanabe, Kenneth K., additional, Thompson, John A., additional, Trisal, Vijay, additional, Urist, Marshall M., additional, McMillian, Nicole, additional, and Ho, Maria, additional

Published
2013
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13. Melanoma

Author

Coit, Daniel G., primary, Andtbacka, Robert, additional, Anker, Christopher J., additional, Bichakjian, Christopher K., additional, Carson, William E., additional, Daud, Adil, additional, Dilawari, Raza A., additional, DiMaio, Dominick, additional, Guild, Valerie, additional, Halpern, Allan C., additional, Hodi, F. Stephen, additional, Kelley, Mark C., additional, Khushalani, Nikhil I., additional, Kudchadkar, Ragini R., additional, Lange, Julie R., additional, Lind, Anne, additional, Martini, Mary C., additional, Olszanski, Anthony J., additional, Pruitt, Scott K., additional, Ross, Merrick I., additional, Swetter, Susan M., additional, Tanabe, Kenneth K., additional, Thompson, John A., additional, Trisal, Vijay, additional, and Urist, Marshall M., additional

Published
2012
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14. Melanoma

Author

Coit, Daniel G., primary, Andtbacka, Robert, additional, Bichakjian, Christopher K., additional, Dilawari, Raza A., additional, DiMaio, Dominick, additional, Guild, Valerie, additional, Halpern, Allan C., additional, Hodi, F. Stephen, additional, Kashani-Sabet, Mohammed, additional, Lange, Julie R., additional, Lind, Anne, additional, Martin, Lainie, additional, Martini, Mary C., additional, Pruitt, Scott K., additional, Ross, Merrick I., additional, Sener, Stephen F., additional, Swetter, Susan M., additional, Tanabe, Kenneth K., additional, Thompson, John A., additional, Trisal, Vijay, additional, Urist, Marshall M., additional, Weber, Jeffrey, additional, and Wong, Michael K., additional

Published
2009
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15. NCCN Guidelines Insights: Uveal Melanoma, Version 1.2019.

Author

Rao PK, Barker C, Coit DG, Joseph RW, Materin M, Rengan R, Sosman J, Thompson JA, Albertini MR, Boland G, Carson Iii WE, Contreras C, Daniels GA, DiMaio D, Durham A, Fields RC, Fleming MD, Galan A, Gastman B, Grossman K, Guild V, Johnson D, Karakousis G, Lange JR, Margolin K, Nath S, Olszanski AJ, Ott PA, Ross MI, Salama AK, Skitzki J, Swetter SM, Wuthrick E, McMillian NR, and Engh A

Subjects
Brachytherapy standards, Education, Medical, Continuing, Eye Enucleation standards, Humans, Medical Oncology education, Medical Oncology methods, Melanoma diagnosis, Melanoma pathology, Oncologists education, Tumor Burden, Uveal Neoplasms diagnosis, Uveal Neoplasms pathology, Medical Oncology standards, Melanoma therapy, Neoplasm Recurrence, Local prevention & control, Practice Guidelines as Topic, Uveal Neoplasms therapy
Abstract

The NCCN Guidelines for Uveal Melanoma include recommendations for staging, treatment, and follow-up of patients diagnosed with uveal melanoma of the choroid or ciliary body. In addition, because distinguishing between uveal melanoma and benign uveal nevi is in some cases difficult, these guidelines also contain recommendations for workup of patients with suspicious pigmented uveal lesions, to clarify the tests needed to distinguish between those who should have further workup and treatment for uveal melanoma versus those with uncertain diagnosis and low risk who should to be followed and later reevaluated. These NCCN Guidelines Insights describe recommendations for treatment of newly diagnosed nonmetastatic uveal melanoma in patients who have already undergone a complete workup.

Published
2020
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16. Melanoma, version 2.2013: featured updates to the NCCN guidelines.

Author

Coit DG, Andtbacka R, Anker CJ, Bichakjian CK, Carson WE 3rd, Daud A, Dimaio D, Fleming MD, Guild V, Halpern AC, Hodi FS Jr, Kelley MC, Khushalani NI, Kudchadkar RR, Lange JR, Lind A, Martini MC, Olszanski AJ, Pruitt SK, Ross MI, Swetter SM, Tanabe KK, Thompson JA, Trisal V, Urist MM, McMillian N, and Ho M

Subjects
Algorithms, Chemotherapy, Adjuvant, Comprehensive Health Care organization & administration, Disease Progression, Education, Medical, Continuing legislation & jurisprudence, Humans, Interferons therapeutic use, Medical Oncology organization & administration, Melanoma diagnosis, Melanoma pathology, Sentinel Lymph Node Biopsy education, Sentinel Lymph Node Biopsy methods, Skin Neoplasms diagnosis, Skin Neoplasms pathology, Societies, Medical legislation & jurisprudence, Societies, Medical organization & administration, Therapies, Investigational methods, Melanoma therapy, Practice Guidelines as Topic, Skin Neoplasms therapy
Abstract

The NCCN Guidelines for Melanoma provide multidisciplinary recommendations on the clinical management of patients with melanoma. This NCCN Guidelines Insights report highlights notable recent updates. Foremost of these is the exciting addition of the novel agents ipilimumab and vemurafenib for treatment of advanced melanoma. The NCCN panel also included imatinib as a treatment for KIT-mutated tumors and pegylated interferon alfa-2b as an option for adjuvant therapy. Also important are revisions to the initial stratification of early-stage lesions based on the risk of sentinel lymph node metastases, and revised recommendations on the use of sentinel lymph node biopsy for low-risk groups. Finally, the NCCN panel reached clinical consensus on clarifying the role of imaging in the workup of patients with melanoma.

Published
2013
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