Search

Obstructive sleep apnea-hypopnea syndrome (OSAHS) may cause pulmonary diseases, and periostin plays an important role on the development of pulmonary diseases. In addition, periostin and pro-inflammatory cytokine TNF-α can regulate each other in vivo. This study aimed to observe the changes of serum periostin and TNF-α levels in patients with OSAHS compared with healthy volunteers and to investigate their correlation. A convenience sample of 67 patients with OSAHS in our hospital from December 2018 to December 2019 was selected and categorized into mild, moderate, and severe groups according to apnea-hypopnea index by polysomnography. In addition, 21 healthy volunteers were selected as the control group. Serum levels of periostin and TNF-α were determined by enzyme-linked immunosorbent assay (ELISA). Results were analyzed using the SPSS software. Both serum periostin and TNF-α levels in all the three OSAHS groups were higher than those of the control group and increased with severity of OSAHS. The severe group had significantly higher serum periostin and TNF-α levels than the mild and moderate groups (p

A number of inherent and thorny obstacles still stand in the way of the practical application of Li–O2 batteries, which require development of an advanced lithium anode and O2 cathode. Herein, the ...

Background Systemic inflammation has a critical role in the pathogenesis of obstructive sleep apnea (OSA). Interleukin (IL)‐35 and IL‐37 have been identified as novel immune‐modulating cytokines with anti‐inflammatory activities in numerous types of inflammatory disease. The present study aimed to examine the serum levels of IL‐35 and IL‐37 in patients with OSA, and to investigate their associations with the severity of OSA. Methods A total of 97 patients, including 67 cases of OSA and 30 age‐ and gender‐matched healthy control subjects, were enrolled in the present study. All subjects were evaluated by overnight polysomnography. Serum IL‐35, IL‐37, and pro‐inflammatory cytokine IL‐1β levels were examined by ELISA. Results Compared with those in the control subjects, serum IL‐35, IL‐37, and IL‐1β levels were significantly elevated in patients with mild, moderate, or severe OSA. Furthermore, a severity‐dependent increase in serum IL‐35 and IL‐37 levels was observed in patients with OSA. IL‐35 and IL‐37 levels were positively correlated with the apnea‐hypopnea index (r = 0.742 and 0.578, respectively; both p, Recently, Interleukin (IL)‐35 and IL‐37 have recently been identified as novel immune‐modulating cytokines with anti‐inflammatory activities in numerous types of inflammatory diseases. However, the potential role of IL‐35 and IL‐37 in obstructive sleep apnea (OSA) remains unknown. We report that serum IL‐35 and IL‐37 levels were significantly increased in patients with OSA and associated with the severity of OSA, implying that IL‐35 and IL‐37 may have a protective role in OSA by counteracting inflammatory responses. To the best of our knowledge, this is the first study analyzing the changes in serum IL‐35 and IL‐37 level and its correlation with the severity of OSA. ​

The hysteresis kinetics of carbon dioxide reduction reaction (CDRR) and evolution reaction (CDER) reaction are major barriers toward the practical implementation of lithium-carbon dioxide (Li-CO2) batteries. Herein, a free-standing and binder-free cathode composed of rutile TiO2 nanorod arrays (TiO2 NAs) and carbonized natural sponge was designed and realized by a simple seeds-assisted construction. The novel air cathode was found to exhibits a high specific capacity of 4.38 mAh cm−2 and long cycle life of more than 1600 h, as well as the discharge products, which would deposit at the surface of the TiO2 NAs rather than carbon substrate during the discharge process. The improved performance can be ascribed to the interconnected conductive sponge framework with macropore and mesoporous channels that can house more discharge products, and the reactant molecules can unrestricted contact with the active sites. Furthermore, the good adhesion to the carbon substrate and the numerous available catalytic sites of the TiO2 NAs contribute intimate contact of the discharge products with the TiO2 NAs, improving CDRR and CDER kinetics effectively and boosting the electrochemical reactions. This TiO2/Sponge represents a promising design in the development of a nature-inspired, self-standing, and binder-free electrode for high-performance Li-CO2 batteries.

to observe the effect of PolyI:C on the expression of TLR3 and inflammation cytokine in the airway smooth muscle cells ASMCs of rat, to investigate relationship between the expression of Toll-like receptor 3 (TLR3) in the airway smooth muscle cells and airway inflammation.airway smooth muscle cells were derived from rat airway tissue and were cultured in vitro, ASMCs were divided into 2 groups: control group and PolyI:C group, PolyI:C group was divided into the different time spots. The mRNA expression of TLR3 was measured by RT-PCR. The level of NF-kappaB was measured by Western blot. The concertration of IL-8 and Eotaxin in ASMCs supernatant were determined by ELISA.the expression of TLR3 mRNA and NF-kappaB protein in the ASMCs in PolyI:C group was significantly higher than those in control group(P0.05), the concentration of IL-8 and Eotaxin in the ASMCs in PolyI:C group was significantly higher compared to control group (P0.05); and have time dependent manner.poly I:C promoted the expression of TLR3 in ASMCs, activated NF-kappaB, incresead the concentration of IL-8 and Eotaxin, involved in airway inflammation of asthma.