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Sub-health state is a state of health and low quality between disease and health. The theoretical basis of children's sub-health is to start from the whole. The common clinical sub-health conditions cannot be explained by modern detection methods, and it can be screened and analyzed with the help of big data in medical informatization. The combination of "Internet + " and the health care model is an innovation in the construction of medical informatization. It can provide many considerate services to the masses in time and alleviate the anxiety of illness. Therefore, it is very necessary to carry out the efficacy evaluation of children's sub-health from the perspective of medical information. Therefore, this paper completes the following work with the help of AI neural network: (1) This paper proposes an improved AlexNet network evaluation method based on attention mechanism. In this study, attention mechanism is added to the original AlexNet model to weight each channel of the feature layer. At the same time, we improve the large convolution kernel of the previous layers of the original AlexNet network and use batch normalization instead of the local response normalization (LRN) layer in the original model. (2) This paper proposes an evaluation method based on improved residual network, which improves the original residual block of the residual model and widens the residual block. The residual block can effectively reduce the amount of network parameters and improve the efficiency of network training. (3) This paper proposes an evaluation method of multi-scale feature fusion (MSFF). The features extracted from the improved AlexNet and residual network are fused and then evaluated. At this time, the training time is greatly shortened, and the accuracy is higher than that of single model. [ABSTRACT FROM AUTHOR]