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1. Diagnostic biologique des angioedèmes bradykiniques : les recommandations du CREAK

Author

Bouillet, Laurence, Defendi, Frederica, Hardy, Gaelle, Cesbron, Jean Yves, Boccon-Gibod, Isabelle, Deroux, Alban, Mansard, Catherine, Launay, David, Gompel, Anne, Floccard, Bernard, Jaussaud, Roland, Beaudouin, Etienne, Armengol, Guillaume, Olliver, Yann, Gayet, Stephane, Du Than, Aureli, Sailler, Laurent, Guez, Stephane, Sarrat, Anne, Sorin, Lucile, de Moreuil, Claire, Pelletier, Fabien, Javaud, Nicolas, Marmion, Nicolas, Fain, Olivier, Fauré, Julien, and Dumestre-Pérard, Chantal

Published
2019
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2. Immediate Hypersensitivity to Contrast Agents: The French 5-year CIRTACI Study

Author

Clement, Olivier, Dewachter, Pascale, Mouton-Faivre, Claudie, Nevoret, Camille, Guilloux, Laurence, Bloch Morot, Evelyne, Katsahian, Sandrine, Laroche, Dominique, Audebert, Martine, Benabes-Jezraoui, Béatrice, Benoit, Yves, Beot, Sylvie, Berard, Frédéric, Berthezene, Yves, Bertrand, Philippe, Bouffard, Juliette, Bourrain, Jean-Luc, Boyer, Bruno, Carette, Marie-France, Caron-Poitreau, Christine, Cavestri, Béatrice, Cercueil, Jean Pierre, Charpin, Denis-André, Collet, Evelyne, Crombe-Ternamian, Arielle, Dalmas, Jacques, Decoux, Eric, Defrance, Marie-France, Delaval, Yvonne, Demoly, Pascal, Depriester, Claude, Depriester, Pascale, Didier, Alain, Drouet, Martine, Dupas, Benoît, Dupre-Goetchebeur, Dominique, Dzviga, Charles, Fabre, Christine, Ferretti, Gilbert, Fourre-Jullian, Corinne, Girardin, Pascal, Giron, Jacques, Gouitaa, Marion, Grenier, Nicolas, Guenard Bilbault, Lydie, Guez, Stéphane, Gunera-Saad, Nathalie, Heautot, Jean-François, Herbin, Dominique, Hoarau, Cyrille, Jacquot, Claude, Julien, Christian, Laborie, Laurent, Lambert, Claude, Larroche, Pascal, Leclerc, Xavier, Lemaitre, Laurent, Leynadier, Francisque, Lillo-Le-Louet, Agnès, Louvel, Jean-Pierre, Louvier, Nathalie, Lucas, Marie-Madeleine, Meites, Geneviève, Mennesson, Nicolas, Metge, Liliane, Meunier, Yannick, Monnier-Cholley, Laurence, Musacchio, Mariano, Nicolie, Brigitte, Occelli, Gisèle, Oesterle, Hélène, Paisant-Thouveny, Francine, Panuel, Michel, Railhac, Nadine, Rety-Jacob, Frédérique, Rochefort-Morel, Cécile, Roy, Catherine, Sarlieve, Philippe, Sesay, Musa, Sgro, Catherine, Taourel, Patrice, Terrier, Patrick, Theissen, Odile, Topenot, Ingrid, Valfrey, Jocelyne, Veillon, Francis, Vergnaud, Marie-Claude, Veyret, Charles, Vincent, Denis, Wallaert, Benoit, Wessel, François, and Zins, Marc

Published
2018
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3. Long-term prophylaxis in hereditary angioedema management: Current practices in France and unmet needs

Author

Bouillet, Laurence, primary, Fain, Olivier, additional, Armengol, Guillaume, additional, Aubineau, Magali, additional, Blanchard-Delaunay, Claire, additional, Dalmas, Marie-Caroline, additional, De Moreuil, Claire, additional, Du Thanh, Aurélie, additional, Gobert, Delphine, additional, Guez, Stéphane, additional, Hoarau, Cyrille, additional, Jaussaud, Roland, additional, Jeandel, Pierre-Yves, additional, Maillard, Hervé, additional, Marmion, Nicolas, additional, Masseau, Agathe, additional, Menetrey, Céline, additional, Ollivier, Yann, additional, Pelletier, Fabien, additional, Plu-Bureau, Geneviève, additional, Sailler, Laurent, additional, Vincent, Denis, additional, Bouquillon, Benoit, additional, Verdier, Edouard, additional, Clerson, Pierre, additional, Boccon-Gibod, Isabelle, additional, and Launay, David, additional

Published
2022
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4. Can We Reduce Frame Rate to 15 Images per Second in Pediatric Videofluoroscopic Swallow Studies?

Author

Clement, Olivier, Dewachter, Pascale, Mouton-Faivre, Claudie, Nevoret, Camille, Guilloux, Laurence, Bloch Morot, Evelyne, Katsahian, Sandrine, Laroche, Dominique, Audebert, Martine, Benabes-Jezraoui, Béatrice, Benoit, Yves, Beot, Sylvie, Berard, Frédéric, Berthezene, Yves, Bertrand, Philippe, Bouffard, Juliette, Bourrain, Jean-Luc, Boyer, Bruno, Carette, Marie-France, Caron-Poitreau, Christine, Cavestri, Béatrice, Cercueil, Jean Pierre, Charpin, Denis-André, Collet, Evelyne, Crombe-Ternamian, Arielle, Dalmas, Jacques, Decoux, Eric, Defrance, Marie-France, Delaval, Yvonne, Demoly, Pascal, Depriester, Claude, Depriester, Pascale, Didier, Alain, Drouet, Martine, Dupas, Benoît, Dupre-Goetchebeur, Dominique, Dzviga, Charles, Fabre, Christine, Ferretti, Gilbert, Fourre-Jullian, Corinne, Girardin, Pascal, Giron, Jacques, Gouitaa, Marion, Grenier, Nicolas, Guenard Bilbault, Lydie, Guez, Stéphane, Gunera-Saad, Nathalie, Heautot, Jean-François, Herbin, Dominique, Hoarau, Cyrille, Jacquot, Claude, Julien, Christian, Laborie, Laurent, Lambert, Claude, Larroche, Pascal, Leclerc, Xavier, Lemaitre, Laurent, Leynadier, Francisque, Lillo-Le-Louet, Agnès, Louvel, Jean-Pierre, Louvier, Nathalie, Lucas, Marie-Madeleine, Meites, Geneviève, Mennesson, Nicolas, Metge, Liliane, Meunier, Yannick, Monnier-Cholley, Laurence, Musacchio, Mariano, Nicolie, Brigitte, Occelli, Gisèle, Oesterle, Hélène, Paisant-Thouveny, Francine, Panuel, Michel, Railhac, Nadine, Rety-Jacob, Frédérique, Rochefort-Morel, Cécile, Roy, Catherine, Sarlieve, Philippe, Sesay, Musa, Sgro, Catherine, Taourel, Patrice, Terrier, Patrick, Theissen, Odile, Topenot, Ingrid, Valfrey, Jocelyne, Veillon, Francis, Vergnaud, Marie-Claude, Veyret, Charles, Vincent, Denis, Wallaert, Benoit, Wessel, François, Zins, Marc, Layly, Julie, Marmouset, Franck, Chassagnon, Guillaume, Sirinelli, Dominique, Cottier, Jean-Philippe, Morel, Baptiste, Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Pathophysiology of the Vigilance States (SLEEP), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Groupe Hospitalier Universitaire Paris Seine-Saint-Denis (GHUPSSD), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Biomnis Laboratory, Service de Médecine Interne [CHU HEGP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Centre de référence des syndromes drépanocytaires majeurs, CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), CHU Amiens-Picardie, Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), Département d'allergie et d'immunologie clinique [CHU Lyon Sud], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Immunologie de l'allergie cutanée et vaccination – Immunology of skin allergy and vaccination, Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Hôpital de la Croix-Rousse [CHU - HCL], Éducation Éthique Santé EA 7505 (EES), Université de Tours (UT), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] (UNICANCER/ICL), UNICANCER, CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Université Paris Cité (UPCité), Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Motricité, interactions, performance EA 4334 / Movement - Interactions - Performance (MIP), Le Mans Université (UM)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université de Nantes - UFR des Sciences et Techniques des Activités Physiques et Sportives (UFR STAPS), Université de Nantes (UN)-Université de Nantes (UN), Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), and Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])

Subjects
Male, medicine.medical_specialty, Adolescent, Pediatrics, Sensitivity and Specificity, [SHS]Humanities and Social Sciences, 030507 speech-language pathology & audiology, 03 medical and health sciences, Speech and Hearing, 0302 clinical medicine, Swallowing, Image Processing, Computer-Assisted, medicine, Humans, Child, ComputingMilieux_MISCELLANEOUS, Retrospective Studies, business.industry, Cineradiography, Gastroenterology, Reproducibility of Results, Frame rate, University hospital, Dysphagia, Deglutition, Pediatric Radiology, Otorhinolaryngology, Child, Preschool, Radiological weapon, Female, Radiology, medicine.symptom, Deglutition Disorders, 0305 other medical science, business, 030217 neurology & neurosurgery, Pediatric population
Abstract

Videofluoroscopic Swallow studies (VFSS) are useful radiological examinations to explore swallowing disorders but which require ionizing radiation. The aim of our study was to evaluate the comparability of pediatric VFSS at 15 frames per second (fps) with 30 fps. Fifty-five loops including 190 swallowings of VFSS at 30 fps performed on 32 consecutive pediatric patients in a University Hospital Center were retrospectively modified by a software to delete one image out of two to obtain secondary loops with a frame rate of 15 fps. An otorhinolaryngologist-phonatrician and a radiologist reviewed all swallowings blindly and randomly using the penetration and aspiration scale (PAS). In case of discordance, they concluded a consensual interpretation. Fifteen girls and seventeen boys were included. The median age was 4 years and 8 months (range = 4 months-16 yr.). 144 swallowings were normal. Swallowing disorder was confirmed in 46 swallowings, (23 supraglottic penetrations and 23 aspirations). Considering each swallowing at 15 fps, sensitivity and specificity were, respectively, 93% (CI 0.82-0.98) and 98% (CI 0.94-0.99). The Cohen'Kappa coefficient between each interpretation at 15 and 30 fps was "almost perfect" (κ = 0.95; CI 0.88-0.99). Considering each loop, conclusion was identical. Reducing frame rate at 15 fps during pediatric VFSS seemed to be acceptable with comparable diagnostic performances without clinical impact compared to 30 fps, while being an efficient way to reduce the ionizing radiation exposition in children. We would suggest reconsidering the possibility of using VFSS with a 15 fps in a pediatric population.

Published
2019

5. Response to commentary by Drs. Poncet and Sénéchal

Author

Klingebiel, Caroline, Chantran, Yannick, Demoly, Pascal, Caimmi, Davide, Birnbaum, Joëlle, Apoil, Pol-André, Caimmi, Davide Paolo, Gouitaa, Marion, Cabon‐boudard, Isabelle, Guez, Stéphane, Bourrain, Jean‐luc, Leroy, Sylvie, Bourrier, Thierry, Aferiat‐derome, Agnès, Sarrat, Anne, Lidholm, Jonas, Vitte, Joana, Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre Hospitalier d'Aix en Provence [Aix-en-Provence] (CHIAP ), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Assistance Publique - Hôpitaux de Marseille (APHM), CHU Bordeaux [Bordeaux], Hôpital Lapeyronie [Montpellier] (CHU), Hôpital Pasteur [Nice] (CHU), Département de Pneumologie et Allergologie Pédiatriques, Centre Hospitalier Universitaire de Nice (CHU Nice), Adhésion et Inflammation (LAI), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), COMBE, Isabelle, Centre de Recherche Saint-Antoine (CR Saint-Antoine), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse], Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance Publique - Hôpitaux de Marseille (APHM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)

Subjects
medicine.medical_specialty, Cupressus, Immunology, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, medicine, Hypersensitivity, Immunology and Allergy, Humans, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, 030304 developmental biology, Prunus persica, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, 0303 health sciences, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, biology, biology.organism_classification, Dermatology, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, 030228 respiratory system, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Pollen, [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, [SDV.MP.PAR] Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology
Abstract

International audience; We thank Drs. Poncet and Sénéchal for their interest and critical reading of our paper. We are well aware of their pioneering work on molecular aspects of cypress pollinosis. However, the focus of our paper was rather on epidemiological, clinical and diagnostic features of peach allergy and not towards molecular pollen determinants. We hereby provide answers to direct questions and notions made by Drs. Poncet and Sénéchal. 1. In regard to literature references, we cited those we found relevant for the scope and purpose of the paper and none of the three reviewers suggested citation of additional publications. To our knowledge, the paper by Hugues et al (2006) was indeed the first to report an association between cypress and peach allergy, and it is cited as reference 39 in our paper 1. However, contrary to the assertion by Poncet and Sénéchal, the authors of that paper did not identify a pollen homologue of Pru p 7, which was first reported as an allergen by Tuppo et al in 2013 2 but instead made the notion "Because both allergenic extracts include a 45 kDa-allergen, it should be the shared allergen." Cup a 1, a major allergen in cypress pollen, has a molecular weight of 43 kDa. Experimental data from the Poncet team are currently available for BP14 and snakin-1, neither of which have been officially recognized and named as allergens by the WHO/IUIS Allergen Nomenclature SubCommittee (www.aller gen.org, accessed May 4 2019). Other papers cited by Poncet et al are either replies or reviews. We prefer citation of original, peer-reviewed research. However, the review on cypress pollinosis is also cited in our paper as ref 41. 3 2. This case report of one patient with discordant FABER IgE and BAT results would have brought little if any further information to the reader. In our hands, the FABER test displays highly sensitive detection of IgE to Pru p 7. 3. As noted above, BP14 has not been officially recognized as an allergen. 4. Snakin-1 is out of the scope of our publication. 5. Recombinant Pru p 7 was biochemically and immunologically characterized as described in section 2.6 4 and additionally by circular dichroism spectroscopy, but, given the focus of the paper, we did not consider it relevant to show and elaborate on such data, nor was there space available. It was also not suggested by any of the three reviewers. However, the BAT results shown in Table S3 demonstrate a similar functional potency of natural and recombinant Pru p 7 which suggests an authentic folding of the recombinant protein. o We do not agree that assessment of anti-microbial activity of recombinant Pru p 7 and several of the other specifics mentioned would be necessary to validate the association between cypress pollen allergy and peach allergy as suggested (but not yet done in their publications) by Drs Poncet and Sénéchal. o The cypress species used was Cupressus sempervirens. o The pollen was extracted and clarified by standard methods. We did not consider total protein concentration to be informative in relation to the purpose of the experiment but chose instead to determine the potency of the extract by titrated inhibition of IgE binding to Pru p 7, as described in section 3.5. That potency determination guided the choice of inhibitor concentration in the single-point inhibitions shown in figure 5A. 15% (w/v) means a concentration corresponding to 15 g of pollen (dry weight) per 100 mL of liquid, a manner of expressing concentrations also used by Poncet et al in their papers. o The specificity of inhibition with the pollen extract was ensured by a complete lack of inhibition of binding of dog dander specific IgE to dog dander ImmunoCAP (e5) and is further indicated by the lack of significant inhibition in some samples as shown in figure 5A. Had the inhibitory effect of the cypress pollen extract been due to unspecific blockade of IgE, no such results would have been obtained. We hope that our response will provide sufficient clarity and explanation to the questions raised by Drs. Poncet and Sénéchal.

Published
2019

9. Pru p 7 sensitization is a predominant cause of severe, cypress pollen‐associated peach allergy.

Author

Klingebiel, Caroline, Chantran, Yannick, Arif‐Lusson, Rihane, Ehrenberg, Angelica E., Östling, Jonas, Poisson, Alain, Liabeuf, Valérie, Agabriel, Chantal, Birnbaum, Joëlle, Porri, Françoise, Sarrat, Anne, Apoil, Pol‐André, Vivinus, Mylène, Garnier, Lorna, Chiriac, Anca Mirela, Caimmi, Davide‐Paolo, Bourrain, Jean‐Luc, Demoly, Pascal, Guez, Stéphane, and Boralevi, Franck

Subjects
PEACH, ALLERGIC rhinitis, FOOD allergy, ALLERGIES, CYPRESS, TEMPERATE climate
Abstract

Background: Peach is a common elicitor of food allergic reactions. Peach‐induced immediate reactions may occur as benign pollen‐food syndromes, usually due to birch pollen‐related PR‐10 cross‐reactivity in temperate climates, and as potentially severe primary food allergies, predominantly related to nsLTP Pru p 3 in Mediterranean regions. The newly described peach allergen Pru p 7 has gained recent attention as a potential peach allergy severity marker. Sensitization to Pru p 7 and its allergenic homologues of the gibberellin‐regulated protein family occurs in areas with high Cupressaceae tree pollen exposure. Objective: We sought to investigate the distribution, clinical characteristics and molecular associations of Pru p 7 sensitization among subjects with suspected peach allergy in different regions of France. Methods: Subjects with suspected peach allergy (n = 316) were included. Diagnostic work‐up was performed according to current guidelines, including open food challenge when required. IgE antibody measurements and competition experiments were performed using the ImmunoCAP assay platform. Results: Sensitization to Pru p 7 was present in 171 (54%) of all subjects in the study and in 123 of 198 (62%) diagnosed as peach allergic, more than half of whom were sensitized to no other peach allergen. Frequency and magnitude of Pru p 7 sensitization were associated with the presence of peach allergy, the clinical severity of peach‐induced allergic reactions and the level of cypress pollen exposure. Cypress pollen extract completely outcompeted IgE binding to Pru p 7. Pru p 7 was extremely potent in basophil activation tests. Conclusion and Clinical Relevance: A subtype of Cupressaceae pollinosis, characterized by Pru p 7 sensitization, can be an underlying cause of severe peach allergy. [ABSTRACT FROM AUTHOR]

Published
2019
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13. Une hypoparathyroïdie aucours dulupus

Author

Attout, Hassene, primary, Guez, Stéphane, additional, Rughoobur, Artee, additional, Bougmiza, Iheb, additional, Dubois, Florent, additional, Durand, Julien, additional, and Seriès, Claire, additional

Published
2007
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15. Clinical management of food allergy.

Author

Guez, Stéphane, Masson, Hervé, Attout, Hassene, and Seriès, Claire

Subjects
*FOOD allergy, *ALLERGIES, *PLACEBOS, *FOOD, *MONOCLONAL antibodies, *ALLERGENS
Abstract

Food allergy is of difficult diagnosis relying on clinical history, skin prick tests and specific IgE antibodies measurements. Therefore, a double blind placebo-controlled oral food challenge is sometimes necessary. The primordial treatment consists in dietetic elimination which is only required for 2% or 3% of adults, and for 6% or 8% of children, who are really allergic because of the risk of anaphylactic reaction after an unintended ingestion. In future, new treatments (immunotherapy, monoclonal antibodies against IgE) and dietary prevention (breast-feeding, delayed introduction of solid foods) should limit the constant increase of these allergies, and facilitated the management, especially for the most frequent and powerful allergens (peanuts). [Copyright &y& Elsevier]

Published
2004
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17. Response to commentary by Drs. Poncet and Sénéchal.

Author

Klingebiel C, Chantran Y, Demoly P, Apoil PA, Caimmi DP, Birnbaum J, Gouitaa M, Cabon-Boudard I, Guez S, Bourrain JL, Leroy S, Bourrier T, Aferiat-Derome A, Sarrat A, Lidholm J, and Vitte J

Subjects
Humans, Pollen, Cupressus, Hypersensitivity, Prunus persica
Published
2019
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18. Efficacy of desensitization via the sublingual route in mite allergy.

Author

Guez S

Subjects
Administration, Sublingual, Animals, Clinical Trials as Topic, Humans, Allergens administration & dosage, Desensitization, Immunologic methods, Hypersensitivity therapy, Mites immunology
Abstract

Desensitization via the sublingual route when treating mite allergy is a new technique in immunotherapy that has aroused the interest of an increasing number of allergists. Assessing its effectiveness is difficult because of the multiplicity of the criteria used by the various published studies to determine what constitutes an improvement. But a critical analysis of the results obtained in the various methodologically rigorous studies suggests that treatment is effective when compared to a placebo. It remains, however, necessary to determine whether or not the sublingual route is superior to the subcutaneous route; its ease of use and harmlessness should not be the only criteria when deciding upon a treatment that above all else should be curative.

Published
2003
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