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Abstract: Induced systemic resistance (ISR) is one of the indirect mechanisms of growth promotion exerted by plant growth‐promoting bacteria, and can be mediated by ethylene (ET). We assessed ET production and the expression of related genes in the Azospirillum–strawberry plant interaction. Ethylene production was evaluated by gas chromatography in plants inoculated or not with A. brasilense REC3. Also, plants were treated with AgNO3, an inhibitor of ET biosynthesis; with 1‐aminocyclopropane‐1‐carboxylic acid (ACC), a precursor of ET biosynthesis; and with indole acetic acid (IAA). Plant dry biomass and the growth index were determined to assess the growth‐promoting effect of A. brasilense REC3 in strawberry plants. Quantitative real time PCR (qRT‐PCR) was performed to analyse relative expression of the genes Faetr1, Faers1 and Faein4, which encode ET receptors; Factr1 and Faein2, involved in the ET signalling pathway; Faacs1 encoding ACC synthase; Faaco1 encoding ACC oxidase; and Faaux1 and Faami1 for IAA synthesis enzymes. Results showed that ET acts as a rapid and transient signal in the first 12 h post‐treatment. A. brasilense REC3‐inoculated plants had a significantly higher growth index compared to control plants. Modulation of the genes Faetr1, Faers1, Faein4, Factr1, Faein2 and Faaco1 indicated activation of ET synthesis and signalling pathways. The up‐regulation of Faaux1 and Faami1 involved in IAA synthesis suggested that inoculation with A. brasilense REC3 induces production of this auxin, modulating ET signalling. Ethylene production and up‐regulation of genes associated with ET signalling in strawberry plants inoculated with A. brasilense REC3 support the priming activation characteristic of ISR. This type of resistance and the activation of systemic acquired resistance previously observed in this interaction indicate that both are present in strawberry plants, could act synergistically and increase protection against pathogens. [ABSTRACT FROM AUTHOR]

The plant growth-promoting strain REC3 of Azospirillum brasilense, isolated from strawberry roots, prompts growth promotion and systemic protection against anthracnose disease in this crop. Hence, we hypothesised that A. brasilense REC3 can induce different physiological, structural and molecular responses in strawberry plants. Therefore, the aim of this work was to study these traits activated in Azospirillum-colonised strawberry plants, which have not been assessed until now. Healthy, in vitro micropropagated plants were root-inoculated with REC3 under hydroponic conditions; root and leaf tissues were sampled at different times, and oxidative burst, phenolic compound content, malondialdehyde ( MDA) concentration, callose deposition, cell wall fortification and gene expression were evaluated. Azospirillum inoculation enhanced levels of soluble phenolic compounds after 12 h post-inoculation (hpi), while amounts of cell wall bound phenolics were similar in inoculated and control plants. Other early responses activated by REC3 (at 24 hpi) were a decline of lipid peroxidation and up-regulation of strawberry genes involved in defence ( Fa PR1), bacterial recognition ( Fa FLS2) and H2O2 depuration ( Fa CAT and Fa APXc). The last may explain the apparent absence of oxidative burst in leaves after bacterial inoculation. Also, REC3 inoculation induced delayed structural responses such as callose deposition and cell wall fortification (at 72 hpi). Results showed that A. brasilense REC3 is capable of exerting beneficial effects on strawberry plants, reinforcing their physiological and cellular characteristics, which in turns contribute to improve plant performance. [ABSTRACT FROM AUTHOR]

The elemental composition of strawberry plants ( Fragaria ananassa cv. Macarena) inoculated with the plant growth-promoting bacterium Azospirillum brasilense REC3, and non-inoculated controls, was studied using scanning electron microscopy ( SEM) and energy dispersive X-ray ( EDS) analysis. This allowed simultaneous semi-quantification of different elements in a small, solid sample. Plants were inoculated and grown hydroponically in 50% or 100% Hoagland solution, corresponding to limited or optimum nutrient medium, respectively. Bacteria-inoculated plants increased the growth index 45% and 80% compared to controls when grown in 100% and 50% Hoagland solution, respectively. Thus, inoculation with A. brasilense REC3 in a nutrient-limited medium had the strongest effect in terms of increasing both shoot and root biomass and growth index, as already described for Azospirillum inoculated into nutrient-poor soils. SEM- EDS spectra and maps showed the elemental composition and relative distribution of nutrients in strawberry tissues. Leaves contained C, O, N, Na, P, K, Ca and Cu, while roots also had Si and Cl. The organic fraction ( C, O and N) accounted for over 96.3% of the total chemical composition; of the mineral fraction, Na had higher accumulation in both leaves and roots. Azospirillum-inoculated and control plants had similar elemental quantities; however, in bacteria-inoculated roots, P was significantly increased (34.33%), which constitutes a major benefit for plant nutrition, while Cu content decreased (35.16%). [ABSTRACT FROM AUTHOR]

Congenital myasthenic syndromes (CMS) are inherited disorders of defective neuromuscular transmission. The clinical phenotype and treatment response vary between the over 30 genetic subtypes. Currently, there is limited published large cohort data in this population. A multicentre international study was undertaken to identify the genetic spectrum, clinical data, treatments, and standardised outcome measures in genetically confirmed CMS patients. Cross sectional data was collected at the time of routine clinic appointment within the last 12-months. Clinical, genetic information and three outcome measures (Myasthenia Gravis Quantitative Score - QMG, Myasthenia Gravis Activities of Daily Living - MG-ADL and Sit to stand in 1 minute - STS1M) were collected. Cohort data analysis was performed on complete data sets, with sub analysis of common subtypes. 187 patients were included, with AChR deficiency 29%, DOK7 20%, RAPSN 17%, COLQ 7%, and Slow Channel 6%. Median age at clinic was 25 years (range 1-83 years). Mean age at symptom onset (n=172) was 2.8 years. Median age at genetic diagnosis (n=174) was 8.4 years. Median age at treatment initiation (n=169) was 5 years. Total QMG score (n=132) was median 12/39 (range 0-34), in AChR deficiency-13 (range 3-34), DOK7-10 (range 0-29), RAPSN-8 (range 2-17). MG-ADL score (n=174), median 5/24 (range 0-20), in AChR deficiency-5 (range 0-18), DOK7-7 (range 0-14), RAPSN-3.5 (range 0-10) and STS1M (n=146), median-22 (range 0-50), AChR deficiency-21.5(range 0-38), DOK7-17.5 (range 4-45) and RAPSN-25 (range 9-50). This is the largest reported CMS cohort including genetics, clinical data, and standardised outcome measures. Significant variability in the outcome measures was noted within individual CMS subtypes. This highlights the wide spectrum but also provides pivotal information for clinical trial designs. STS1M was identified as a robust easy deliverable outcome measure of fatigable weakness across all ages. [ABSTRACT FROM AUTHOR]

Introduction: Cerebral amyloid angiopathy-related inflammation (CAA-ri) is an entity characterised by an inflammatory response to β-amyloid deposition in the walls of cerebral microvessels., Methods: We conducted a retrospective review of a series of patients with a diagnosis of CAA-ri according to histopathological study findings or clinical-radiological diagnostic criteria., Results: The study included 7 patients (5 men) with a mean age of 79 years. Disease onset was acute or subacute in 6 patients. The most frequent symptoms were cognitive impairment (n = 6), behavioural alterations (n = 5), epileptic seizures (n = 5), focal neurological signs (n = 4), and headache (n = 2). Cerebrospinal fluid was abnormal in 3 patients (lymphocytic pleocytosis and high protein levels). The most frequent MRI findings were microbleeds (n = 7), subcortical white matter hyperintensities on T2-FLAIR sequences (n = 7), and leptomeningeal enhancement (n = 6). Lesions were bilateral in 3 patients and most frequently involved the parieto-occipital region (n = 5). Amyloid PET studies were performed in 2 patients, one of whom showed pathological findings. Two patients underwent brain biopsy, which confirmed diagnosis. All patients received immunosuppressive therapy. An initially favourable clinical-radiological response was observed in all cases, with 2 patients presenting radiological recurrence after treatment withdrawal, with a subsequent improvement after treatment was resumed., Conclusions: Early diagnosis of CAA-ri is essential: early treatment has been shown to improve prognosis and reduce the risk of recurrence. Although a histopathological study is needed to confirm diagnosis, clinical-radiological criteria enable diagnosis without biopsy., (Copyright © 2021 Sociedad Española de Neurología. Published by Elsevier España, S.L.U. All rights reserved.)

This work studies the emotional and behavioural difficulties and the personal wellbeing of adolescents under protective measures. The sample is made up of 151 adolescents in residential care between 11 and 17 years of age. The instruments used were the Strengths and Difficulties Questionnaire (SDQ) and the Personal Wellbeing Index (PWI). The results indicate that a high percentage of adolescents have emotional and behavioural difficulties. We found a greater presence of behavioural rather than emotional problems in the adolescents. Similarly, we also found that females showed more emotional difficulties than the males. As for personal wellbeing, the results indicate that the adolescents are dissatisfied in several areas of their life, they feel insecure and have a pessimistic view of their future and of their achievements. Furthermore, those adolescents who were admitted to residential care due to something other than child abuse have a greater prosocial behaviour. It can be concluded that the more difficulties the adolescents experience (emotional, behavioural and with their peers), the lower the perception of their personal wellbeing will be. This study allows us to design interventions aimed at promoting psychological wellbeing among these adolescents.

The main objective of this study is to analyze well-being at work, considering burnout and engagement distributed in profiles, and to observe how they relate to well-being outside work. The data came from a representative sample of workers ( n = 565) at the University of Extremadura (Spain), both teaching and research academic staff (TRAS) and service and administrative staff (SAS). We performed the data analysis by using latent profile analysis, and the results show evidence that workers from both groups were distributed across four profiles. As expected, we verified that workers in the profile with high burnout and low engagement had lower well-being outside work than workers in the profile with high engagement and low burnout. We also observed that engagement mitigated the negative effects of burnout on workers in profiles with moderate levels of burnout, who showed better well-being outside work when they had higher engagement. These differences are discussed, and their practical implications and suggestions for future research are provided.

This bibliographic review analyses the utility for psychologists of using neuroimaging tests and psychological or neuropsychological tests at the same time for studying the functioning of the brain in male abusers condemned for intimate partner violence against women (IPVAW). So as to be able to find an answer, we reviewed the available studies that investigated the structure or functioning of the brain. The results of these reviewed works of research show the benefits of using neuroimaging applied to male abusers, together with the use, either simultaneously or not, of other types of psychological, neuropsychological, or observational tests to complement and/or amplify the results of the neuroimaging techniques, as this can help us to advance in the knowledge of neuroscience as concerns the mind of the male abuser.

Recent advances in sexual equality and diversity have not been able to mitigate the serious problem of discrimination suffered by sexual minorities. The most serious cases involve violence and physical or psychological aggression towards sexual orientations that differ from the heterosexual norm. This research analyses the dimensions of the personality and the moral disengagement mechanisms related to homophobia and the predictive value they have for hostile attitudes towards sexual diversity. The sample was made up of 849 university students between 18 and 24 years of age. The instruments used were the Modern Homophobia Scale (MHS), the Mechanisms of Moral Disengagement Scale (MMDS), and the reduced version of the Neo Personality Inventory-Reduced Version (NEO-FFI). The results show the involvement of moral disengagement in homophobia. It highlights evidence of subtle intimidatory behaviour patterns of rejection towards homosexuality. Furthermore, the low levels in the dimensions of a friendly personality and openness to experiences can be seen to predict homophobic behaviour. Thus, young people fall back on diverse mechanisms of moral disengagement to justify harmful attitudes towards the LGTBI collective. The results of the research are particularly relevant and useful for setting up programmes aimed at preventing and mitigating this serious problem of sexual discrimination.

Psychopaths are portrayed as deceitful, manipulative, domineering and narcissistic; the result of an irregular and irresponsible interpersonal style that harms both the psychopath him/herself and others. Furthermore, psychopathy is frequently associated with both violent and antisocial conduct. However, subclinical psychopaths are known for manifesting this type of profile without committing crimes. The objective of this study is to examine the differences that exist in subclinical psychopathy concerning gender, the number of intimate relationships and the age of the university student. The number of university students participating was 1289. They were given the Integrated/Subclinical Psychopathy Questionnaire (CUPIS). The results show that, in subclinical psychopathy, men present higher scores than women and younger persons have higher scores than older persons. In addition, the scores in psychopathy are higher for students who have had a larger number of intimate relationships. The contributions of this study allow us to determine the profile associated with subclinical psychopathy.

Serial murder is a specific type of violent crime that falls into the crime category of multicide. According to the nomenclature of the Federal Bureau of Investigation's Violent Crime Classification Manual and Academic Researchers for the Classification of Violent Crimes, most serial killers are adults. However, serial murder is also committed by young people, although to a lesser extent. Young serial killers are a topic of relevance in areas such as psychology, criminology, and the justice system. Given that the study of the variables that could be the basis of such multicide criminality is not conclusive, the need for further research is evident. The homicides perpetrated by children and young people point to a social panorama that is alarming due to their young age. This issue is prevalent enough to conduct a review. The performed review concludes the importance of psychosocial factors to better understand the process by which children and young people commit crimes as serious as serial murders. The scope of the problem of serial murders perpetrated by minors is controversial because it often depends on how the number of real cases is counted. Although official statistics indicate the low prevalence of juvenile serial killers, childhood is a period in which antisocial behaviour can have its beginning. Some authors consider that it is not uncommon for the first murder of this type to occur in adolescence. It is important to consider psychopathy as an influential factor in the various forms of serial criminal conduct committed by children and young people. The research works consulted provide evidence of the special relevance of psychopathy in the generation of serious juvenile delinquency.

This research studies the executive processes of youths under protective measures between 13 and 18years of age, as well as the emotional problems they have and the presence of behavioural problems, such as difficulties to control and direct attention, to control one's own behaviour and inhibit inadequate or ineffective responses (hyperactivity-impulsiveness) and problems related to emotional regulation. In addition, we study the presence of significant differences according to the sex of the youths. We also analyse to what extent the difficulties in the executive processes are related to and can predict the emotional and behavioural problems. The instruments used were Stroop's Colour and Word Test (Stroop), the Paths Test (TESen), and the System of Evaluation for Children and Adolescents (SENA). The results indicated that the youths had difficulties in such executive processes as execution, speed, and accuracy in carrying out tasks. Furthermore, they had emotion problems, amongst which the symptoms of anxiety are worthy of note; whilst attention deficit, hyperactivity-impulsiveness, and problems related to emotional regulation could also be observed. The data indicated greater difficulties in the executive processes for males than for females. There was a greater emotional symptomatology in the females, whilst there were greater deficits in attention and hyperactivity/impulsiveness in the males. Similarly, the deficits in the executive processes were related to and predicted emotional and behavioural problems. This research suggests the design of a structured programme focused on systematic training in real, daily situations, recommending the use of restorative techniques to work on the affected cognitive skills and techniques aimed at improving the youths' emotion regulation., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Moreno-Manso, García-Baamonde, Guerrero-Barona, Godoy-Merino, Guerrero-Molina and Barbosa-Torres.)

The suicide rate in the police force (Fuerzas y Cuerpos de Seguridad-FFCCSS) is estimated to be greater than that of the general population. The objectives of this paper are to detect mental health problems, in particular depression and anxiety, and to analyze the moderating effect of coping strategies on the relation between mental health and suicide ideation in police officers. The Suicidal Behavior Questionnaire (SBQ-R), Beck's Depression Inventory (BDI), the Anxiety Inventory (STAI), and the Brief Cope have all been used in the study. The sample consists of 98 Spanish police officers, of whom 91.8% were male. The results indicate that depression and anxiety can predict suicidal ideation. Nevertheless, it must be said that coping strategies do not have a moderating effect in the relation between mental health and suicidal ideation in this professional group.

Introduction: Cerebral amyloid angiopathy-related inflammation (CAA-ri) is an entity characterised by an inflammatory response to β-amyloid deposition in the walls of cerebral microvessels., Methods: We conducted a retrospective review of a series of patients with a diagnosis of CAA-ri according to histopathological study findings or clinical-radiological diagnostic criteria., Results: The study included 7 patients (5 men) with a mean age of 79 years. Disease onset was acute or subacute in 6 patients. The most frequent symptoms were cognitive impairment (n = 6), behavioural alterations (n = 5), epileptic seizures (n = 5), focal neurological signs (n = 4), and headache (n = 2). Cerebrospinal fluid was abnormal in 3 patients (lymphocytic pleocytosis and high protein levels). The most frequent MRI findings were microbleeds (n = 7), subcortical white matter hyperintensities on T2-FLAIR sequences (n = 7), and leptomeningeal enhancement (n = 6). Lesions were bilateral in 3 patients and most frequently involved the parieto-occipital region (n = 5). Amyloid PET studies were performed in 2 patients, one of whom showed pathological findings. Two patients underwent brain biopsy, which confirmed diagnosis. All patients received immunosuppressive therapy. An initially favourable clinical-radiological response was observed in all cases, with 2 patients presenting radiological recurrence after treatment withdrawal, with a subsequent improvement after treatment was resumed., Conclusions: Early diagnosis of CAA-ri is essential: early treatment has been shown to improve prognosis and reduce the risk of recurrence. Although a histopathological study is needed to confirm diagnosis, clinical-radiological criteria enable diagnosis without biopsy., (Copyright © 2021 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.)

The objective of this work is to study the quality of working life associated to psychosocial factors and risks, burnout syndrome and emotional intelligence, as well as being able to detect predictors of the said syndrome. The sample consisted of 311 professionals working in direct contact with an intellectual disability from 15 associations of Extremadura (Spain). The Spanish version of the CESQT questionnaire was administered to evaluate burnout syndrome, the Wong & Law Emotional Intelligence Scale (WLEIS) was used to evaluate emotional intelligence, while the UNIPSICO Battery was used to evaluate the psychosocial factors of demands (work-family conflict and psychosomatic problems) and resources, such as social support and work satisfaction. The results indicate average values of burnout, revealing that work satisfaction, emotional intelligence, and social support are related to burnout syndrome. In addition, there are also positive correlations between psychosomatic symptoms and work-family conflict. Satisfaction at work, social support, and emotional intelligence (intrapersonal and interpersonal perception, use and regulation of emotions) predict burnout syndrome. What is more, the psychosomatic symptoms and work-family conflict explain, respectively, 17% and 17.9% of their variance. Thus, there is a need to develop intervention programs that encourage social support and the conciliation of family life, as well as training skills related to emotional intelligence, such as communication and conflict resolution.

This work analyzes how the assumption of responsibility by aggressors convicted for gender-based violence is related to sexist attitudes, self-esteem and perceived functional social support. Similarly, the predictive capacity of these variables is studied with respect to the aggressors' minimization of the harm done and a lack of attributing responsibility to themselves. The participants in the research were males condemned to prison sentences for crimes related with gender-based violence in Spain. The instruments applied were the Attribution of Responsibility and Minimization of Harm Scale, the Ambivalent Sexism Inventory (ASI), the Rosenberg Self-Esteem Scale (RSE), the Functional Social Support Questionnaire (FSSQ), and the Social Desirability Scale (SDS). The study concludes that sexist attitudes are related with a greater lack of attribution of responsibility, as well as with a greater tendency to minimize the harm done by the aggression. In addition, the aggressors with low self-esteem use self-defense as a strategy to justify the violence. Similarly, the presence of an adequate social support network for the aggressor increases the attribution of responsibility on the part of those convicted for gender-based violence.

This research analyses the emotional and behavioural problems, as well as the problems in the executive functions, of children in residential care under protective measures, between 8 and 12 years of age. We analyse the relationship between the problems with their executive functions and their emotional and behavioural problems, as well as the predictive value of the executive functions for the said emotional and behavioural problems. The instruments used were as follows: five digits test (FDT), behavioural assessment of the dysexecutive syndrome in children (BADS-C) and the system of evaluation for children and adolescents (SENA). The results indicate that the children have difficulties in their executive functions, with such problems as in attention control and regulation, impulsiveness, mental rigidity, behavioural organisation and planning and resolving problems. They also have internalising and externalising problems, as well as difficulties in controlling their emotional reactions and understanding the emotions of others. It becomes evident that the difficulties in their executive functions are related to and predict their emotional and behavioural problems. The research demonstrates the need to intervene in the problems detected through the design of therapeutic programmes and interventions in the residential context.

Purpose: The purpose of this study was to compare the peripapillary retinal nerve fibre layer (RNFL) between patients with genetic generalized epilepsy (GGE) and healthy controls., Methods: This prospective observational study was conducted on adults aged 18-60 years. The study group comprised 26 consecutive patients who met the inclusion criteria and 26 healthy age- and sex-matched healthy adults. Peripapillary RNFL thickness was measured by spectral domain optical coherence tomography., Results: The average peripapillary RNFL thickness was significantly thinner for GGE patients (98.61 μm) than for healthy controls (104.77 μm) (p = 0.016). Similar results were obtained for the left eye. The peripapillary RFNL thickness of all quadrants was lower for GGE patients than for healthy controls, but it was significant only in the superior (p = 0.009) and inferior (p = 0.024) quadrants for both eyes., Conclusions: Our results suggest that the peripapillary RNFL is significantly thinner in GGE patients than in healthy participants. We concluded that this microstructural feature might be an intrinsic feature of GGE., (Copyright © 2019 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.)