186 results on '"Guerreiro I"'
Search Results
2. A multiple endpoint approach reveals potential in vitro anticancer properties of thymoquinone in human renal carcinoma cells
- Author
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Costa, J.G., Keser, V., Jackson, C., Saraiva, N., Guerreiro, Í., Almeida, N., Camões, S.P., Manguinhas, R., Castro, M., Miranda, J.P., Fernandes, A.S., and Oliveira, N.G.
- Published
- 2020
- Full Text
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Catalog
3. Effect of dietary ARA/EPA/DHA ratios on growth performance and intermediary metabolism of gilthead sea bream (Sparus aurata) juveniles
- Author
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Magalhães, R., Guerreiro, I., Coutinho, F., Moutinho, S., Sousa, S., Delerue-Matos, C., Domingues, V.F., Olsen, R.E., Peres, H., and Oliva-Teles, A.
- Published
- 2020
- Full Text
- View/download PDF
4. Long term prognosis of acute pulmonary embolism
- Author
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Guerreiro, I., Magalhães, H., Coelho, S., Ribeiro, A., Ferreira, S., Araújo, E., Bettencourt, P., and Lourenço, P.
- Published
- 2019
- Full Text
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5. Oxidative status and intestinal health of gilthead sea bream (Sparus aurata) juveniles fed diets with different ARA/EPA/DHA ratios
- Author
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Magalhães, R., Guerreiro, I., Santos, R. A., Coutinho, F., Couto, A., Serra, C. R., Olsen, R. E., Peres, H., and Oliva-Teles, A.
- Published
- 2020
- Full Text
- View/download PDF
6. Water Use and Productivity of Maize-based Cropping Systems in the Alqueva Region (Portugal)
- Author
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Tomaz, A., Patanita, M., Guerreiro, I., Boteta, L., and Palma, J.F.
- Published
- 2017
7. Validation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery
- Author
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Ahmed, W, Bhatia, S, Mclean, K, Khaw, R, Baker, D, Kamarajah, S, Bell, S, Nepogodiev, D, Harrison, E, Glasbey, J, Borakati, A, Burke, J, Drake, T, Bath, M, Claireaux, H, Gundogan, B, Mohan, M, Deekonda, P, Kong, C, Joyce, H, Mcnamee, L, Woin, E, Khatri, C, Fitzgerald, J, Bhangu, A, Arulkumaran, N, Duthie, F, Hughes, J, Pinkney, T, Prowle, J, Richards, T, Thomas, M, Blanco-Colino, R, Chapman, S, Pata, F, Pellino, G, Sgro, A, van Elst, T, Van Straten, S, Knowles, C, Dynes, K, Patel, M, Patel, P, Wigley, C, Suresh, R, Shaw, A, Klimach, S, Jull, P, Evans, D, Preece, R, Ibrahim, I, Manikavasagar, V, Smith, R, Brown, F, Teo, R, Sim, D, Logan, A, Barai, I, Amin, H, Suresh, S, Sethi, R, Gul, W, Bolton, W, Corbridge, O, Horne, L, Attalla, M, Morley, R, Robinson, C, Hoskins, T, Mcallister, R, Lee, S, Dennis, Y, Nixon, G, Heywood, E, Wilson, H, Ng, L, Samaraweera, S, Mills, A, Doherty, C, Belchos, J, Phan, V, Lim, M, Miller, F, Chouari, T, Gardner, T, Goergen, N, Hayes, J, Macleod, C, Mccormack, R, Mckinley, A, Mckinstry, S, Milligan, W, Ooi, L, Rafiq, N, Sammut, T, Sinclair, E, Smith, M, Wong, J, Ablett, A, Tie-Gill, T, Ramsay, G, De Paola, L, Mcguckin, S, Alshakhs, A, Ahmeidat, A, Francis, A, Baker, C, Boulton, A, Collins, J, Copley, H, Fearnhead, N, Fox, H, Mah, T, Mckenna, J, Naruka, V, Nigam, N, Nourallah, B, Perera, S, Qureshi, A, Saggar, S, Sun, L, Wang, X, Yang, D, Ali, Z, Mullarkey, L, Walshe, R, Lewis, E, Berry, B, Moneim, J, Mookerjee, S, Al-Hadithi, A, Caroll, P, Doyle, C, Elangovan, S, Falamarzi, A, Gascon Perai, K, Greenan, E, Jain, D, Lang-Orsini, M, Lim, S, O'Byrne, L, Ridgway, P, Van der Laan, S, Arthur, J, Barclay, J, Bradley, P, Edwin, C, Finch, E, Hayashi, E, Hopkins, M, Kelly, D, Kelly, M, Mccartan, N, Ormrod, A, Pakenham, A, Christy, S, Hayward, J, Hitchen, C, Kishore, A, Martins, T, Philomen, J, Rao, R, Rickards, C, Burns, N, Copeland, M, Durand, C, Dyal, A, Ghaffar, A, Gidwani, A, Grant, M, Gribbon, C, Gruhn, A, Leer, M, Ojofeitimi, O, Carroll, L, Hylands, A, Delaugere, L, Reveendran, D, Ahmad, K, Beattie, G, Beatty, M, Campbell, G, Donaldson, G, Graham, S, Holmes, D, Kanabar, S, Liu, H, Mccann, C, Stewart, R, Vara, S, Coulter, C, Ralston, C, Laverty, L, Gallagher, P, Ajibola-Taylor, O, Andah, E, Ani, C, Cabdi, N, Ito, G, Jones, M, Komoriyama, A, Titu, L, Ahmed, A, Yeo, Y, Elliott, D, Bennett, J, Mcnamara, M, Sivarajah, S, Dunmore, C, Basra, M, Gallogly, P, Harinath, G, Leong, S, Pradhan, A, Siddiqui, I, Zaat, S, Ali, A, Galea, M, Looi, W, Ng, J, Farhan-Alanie, M, Aitken, G, Nair, M, Aly, M, Buari, M, Atkin, G, Azizi, A, Cargill, Z, China, Z, Elliot, J, Jebakumar, R, Lam, J, Mudalige, G, Onyerindu, C, Renju, M, Shankar Babu, V, Ahmed, K, Sheikh, Z, Monks, M, Lehmann, J, Rotimi, O, Hussain, M, Joji, N, Lovett, B, Mownah, H, Dwyer-Hemmings, L, Busuttil, A, Powell, J, Hensher, C, Vivian, F, Ali, B, Cresswell, B, Dhillon, A, Dupaguntla, Y, Hungwe, C, Lowe-Zinola, J, Tsang, J, Wcislo, K, Bevan, K, Cardus, C, Duggal, A, Hossain, S, Mchugh, M, Scott, M, Millar, Z, Hirosue, S, Ogunmwonyi, I, Nakakande, D, Chan, F, Evans, R, Gurung, E, Haughey, B, Jacob-Ramsdale, B, Kerr, M, Lee, J, Mccann, E, O'Boyle, K, Reid, N, Kwek, I, Gaze, H, Nirmalanantha, A, Bin Amran, M, Foulkes, A, Jones, N, Lau, I, Hayat, F, Hodgson, S, Johnston, R, Jones, W, Khan, M, Linn, T, Long, S, Seetharam, P, Shaman, S, Smart, B, Pillai, S, Khoury, G, Powell, T, Maleyko, I, Sangheli, A, Ransome, M, Isse, M, Aromolaran, O, Bholah, H, Anilkumar, A, Davies, J, Griffith, J, Hughes, B, Islam, Y, Kidanu, D, Mushaini, N, Qamar, I, Robinson, H, Schramm, M, Yan Tan, C, Murray, V, Theocharidou, L, Malik, T, Janmohamed, I, Carhart, B, Khan, A, Apperley, H, Billyard, C, Blazeby, J, Cannon, S, Carse, S, Gopfert, A, Loizidou, A, Parkin, J, Sanders, E, Sharma, S, Slade, G, Telfer, R, Whybrow Huppatz, I, Worley, E, Asif, A, Hullait, R, Quinn, P, Rylance, A, Butt, S, Leathes, J, Chandramoorthy, L, Friend, C, Harris, L, Jain, P, Karim, M, Killington, K, Mcgillicuddy, J, Rafferty, C, Rahunathan, N, Rayne, T, Varathan, Y, Verma, N, Zanichelli, D, Arneill, M, Campbell, B, Crozier, L, Henry, J, Mccusker, C, Prabakaran, P, Wilson, R, Karelia, S, Clements, J, Rainey, M, Asif, U, Connor, M, Dindyal, S, Math, N, Pagarkar, A, Saleem, H, Seth, I, Standfield, N, Swartbol, T, Adamson, R, Choi, J, El Tokhy, O, Ho, W, Javaid, N, Mehdi, A, Menon, D, Plumptre, I, Sturrock, S, Turner, J, Warren, O, Joshi, N, Rahman, A, Gallagher, M, Crane, E, Ferris, B, Gadsby, C, Smallwood, J, Vipond, M, Wilson, V, Amarnath, T, Doshi, A, Gregory, C, Kandiah, K, Powell, B, Spoor, H, Toh, C, Vizor, R, Rebuffa, N, Abdelgalil, R, Siaw Yen Lai, R, Smith, E, Common, M, Dunleavy, K, Harris, S, Luo, C, Mesbah, Z, Prem Kumar, A, Redmond, A, Skulsky, S, Walsh, T, Daly, D, Deery, L, Epanomeritakis, E, Harty, M, Kane, D, Khan, K, Mackey, R, Mcconville, J, Mcginnity, K, Wong, H, Ang, A, Kee, J, Leung, E, Norman, S, Palaniappan, S, Partha Sarathy, P, Yeoh, T, Frost, J, Hazeldine, P, Jones, L, Karbowiak, M, Macdonald, C, Mutarambirwa, A, Omotade, A, Runkel, M, Ryan, G, Sawers, N, Searle, C, Vig, S, Hlukha, L, Pike, G, Kamel, F, Thakkar, R, Mcauliffe, O, Ahmad, A, Mcgartland, R, Sim, R, Song, A, Wayman, J, Brown, R, Chang, L, Concannon, K, Crilly, C, Arnold, T, Burgin, A, Cadden, F, Choy, C, Coleman, M, Lim, D, Luk, J, Mahankali-Rao, P, Prudence-Taylor, A, Ramakrishnan, D, Russell, J, Fawole, A, Gohil, J, Green, B, Hussain, A, Mcmenamin, L, Tang, M, Azmi, F, Benchetrit, S, Cope, T, Haque, A, Harlinska, A, Holdsworth, R, Ivo, T, Martin, J, Nisar, T, Patel, A, Sasapu, K, Trevett, J, Vernet, G, Aamir, A, Bird, C, Durham-Hall, A, Gibson, W, Hartley, J, May, N, Maynard, V, Goble, M, Downs, E, Wheldon, L, Baggus, E, Mandal, A, Nayeem, A, Ahmed, S, Fradley, W, Johnson, S, McDonald Wood, C, O'Brien, M, Orbell, J, Stringfellow, T, Tenters, F, Tresidder, S, Wilson, C, Gallagher, S, Criswell, T, Ward, J, Mukkavilli, A, Stubbs, B, Fordyce, W, Cheung, W, Grant, A, Tod, N, Yi Tew, Z, Suchdev, N, Wei Lim, S, Bews-Hair, M, Lim, Z, Vella-Baldacchino, M, Auckburally, S, Chopada, A, Easdon, S, Goodson, R, Mccurdie, F, Narouz, M, Radford, A, Rea, E, Taylor, O, Yu, T, Sookramanien, S, Chan, A, Bointas, G, Alfa-Wali, M, Amani, L, Auluck, I, Bruce, P, Emberton, J, Kumar, R, Lagzouli, N, Mehta, A, Murtaza, A, Raja, M, Dennahy, I, Frew, K, Given, A, He, Y, Macdonald, E, Mcvinnie, D, Ng, S, Pettit, A, Berthaume-Hawkins, S, Charnley, R, Fenton, K, Jones, D, Murphy, C, Reehal, R, Seraj, S, Shang, E, Tonks, A, White, P, Yeo, A, Paul, M, Ward, K, Bagnall, M, Chong, P, Gabriel, R, Patel, N, Richardson, E, Symons, L, Aubrey-Jones, D, Dawood, S, Dobrzynska, M, Faulkner, S, Griffiths, H, Mahmood, F, Perry, M, Power, A, Simpson, R, Pherwani, S, Wang, K, Mitchell, L, Heyworth, J, Ayyar, S, Brobbey, P, Burrows, A, Elder, P, Ganyani, R, Horseman, C, Hurst, P, Mann, H, Marimuthu, K, Mcbride, S, Pilsworth, E, Powers, N, Stanier, P, Obukofe, R, Polson, R, Mason, D, Mackenzie, E, Innes, R, Kersey, T, Kopczynska, M, Langasco, N, Rajagopal, R, Russell, C, Doyle, N, Habib, Z, Zardab, M, Sartaj, F, Farooq, H, Tabibi, M, Imam, L, Atkins, B, Beasley, W, Cheng Lim, Z, Gill, A, Li Ang, H, Williams, H, Yogeswara, T, Drury, D, James, S, Barnett, R, Teasdale, A, Thomas, D, Williams, R, Najabat-Lattif, H, Akram, B, Carter, R, Fam, M, Fong, J, Latter, J, Long, M, Mackinnon, S, Mckenzie, C, Osmanska, J, Raghuvir, V, Shafi, A, Tsang, K, Walker, L, Cahya, E, Lou, G, Coyle, M, Homyer, K, Zhu, L, Woods, M, Bountra, K, Coldicutt, O, Fletcher, D, Hudson, S, Iqbal, S, Lopez Bernal, T, Moss-Lawton, F, Suchett-Kay, I, Chang, J, O'Callaghan, H, Suchett-Kaye, I, Mihailidis, T, Cardwell, A, Edgerton, K, Laws, J, Rai, A, Robinson, K, Waite, K, Youssef, H, Alawattegama, H, Seite, E, Barrett, A, Riordan, E, Lam, W, Dowdeswell, M, Mulvenna, C, Knight, C, Koo, P, Lazarou, A, Stanger, S, Thorn, C, Triniman, M, Netke, T, Awokoya, O, Gurowich, L, Dhera, K, Hossaini, S, Botha, A, Boyles, L, Cumming, S, Deepak, S, Ezzat, A, Fowler, A, Gwozdz, A, Hussain, S, Khan, S, Li, H, Lu Morrell, B, Neville, J, Nitiahpapand, R, Pickering, O, Sagoo, H, Sharma, E, Welsh, K, Williams, L, Hayat, S, Tincknell, L, Spazzapan, M, Teeling, F, Sysum, K, Denley, S, Latter, M, Agarwal, M, Al-Saadi, N, Bhambra, R, Gupta, A, Jawad, Z, Jiao, L, Mahir, G, Singagireson, S, Thoms, B, Tseu, B, Wei, R, Yang, N, Britton, N, Leinhardt, D, Mahfooz, M, Palkhi, A, Price, M, Sheikh, S, Barker, M, Bowley, D, Cant, M, Datta, U, Farooqi, M, Lee, A, Morley, G, Naushad Amin, M, Parry, A, Patel, S, Strang, S, Yoganayagam, N, Guruswamy, M, Beedham, W, Brazier, E, Elghobashy, M, Bajaj, M, Etel, E, Adlan, A, Chandramoorthy, S, Choudhary, Y, Das, K, Feldman, M, France, B, Grace, R, Puddy, H, Soor, P, Kisiel, A, Woodmass, M, Hayden, H, Ali, Y, Husain, S, Ali, M, Dhillon, P, Faraj, A, Gerard, L, Glover, M, Imran, H, Kim, S, Patrick, Y, Peto, J, Prabhudesai, A, Tang, A, Vadgama, N, Dhaliwal, R, Ecclestone, T, Harris, A, Ong, D, Patel, D, Philp, C, Stewart, E, Wang, L, Wong, E, Xu, Y, Ashaye, T, Fozard, T, Galloway, F, Kaptanis, S, Mistry, P, Nguyen, T, Olagbaiye, F, Osman, M, Philip, Z, Rembacken, R, Tayeh, S, Theodoropoulou, K, Liu, F, Arnold, A, Pedersen, A, Cunha, P, Ahmed, M, Al Zawawi, S, Kudva, V, Herman, A, Lau, J, Saha, A, Trotter, M, Miscampbell, M, Robinson, A, Johnston, J, Dharni, A, Lamb, S, Westerman, T, Adeleye, O, Cave, D, Gunwa, T, Magalhaes, J, Makwana, S, Mason, R, Parish, M, Regan, H, Renwick, P, Roberts, G, Salekin, D, Sivakumar, C, Tariq, A, Liew, I, Mcdade, A, Stewart, D, Evans, E, Campbell, L, Gillespie, M, Cheong, C, Hague, M, Hudson-Peacock, N, Jackson, C, James, F, Pitt, J, Walker, E, Kulathevanayagam, K, Varghese, A, Ike, S, Aftab, R, Ang, J, Anwar, S, Battle, J, Budd, E, Chui, J, Crook, H, Davies, P, Easby, S, Hackney, E, Ho, B, Imam, S, Rammell, J, Chu, T, Baljer, B, Mogg, J, Rai, P, Andrews, H, Perry, C, Schinle, P, Ahmed, P, Aquilina, T, Balai, E, Church, M, Cumber, E, Curtis, A, Davies, G, Dumann, E, Greenhalgh, S, Kim, P, King, S, Metcalfe, K, Passby, L, Redgrave, N, Soonawalla, Z, Waters, S, Zornoza, A, Williams, M, Smillie, R, Goetz, J, Appleby, E, Fadipe, T, Vaughan-Burleigh, S, Davies, R, Gulzar, I, Hole, J, Hull, K, Ishaq, H, Karaj, J, Kelkar, A, Love, E, Thakrar, D, Vine, M, Waterman, A, James, P, Puri, G, Hussain, P, Flather, R, Cutler, A, Pathak, S, Sheldon, J, Collicott, T, al-Ausi, M, Ko, M, Dib, N, Francis, N, Hanson, M, Ingleton, R, Sadanand, K, Sukirthan, N, Mondal, A, Jovaisaite, A, Shah, S, Khalid, N, Gutmann, D, Davison, S, Alame, Y, Syed, L, Owen, W, Arnell, S, Ball, M, Bassam, N, Beghal, G, Chang, A, Dawe, V, George, A, Huq, T, Ikram, B, Kanapeckaite, L, Ramjas, D, Rushd, A, Sait, S, Serry, M, Yardimci, E, Kalderon, R, Ahsan, S, Anthony-Uzoeto, U, Macleod Hall, C, Zheng, S, Wynter, K, Capella, S, Chenciner, L, Episkopos, C, Karam, E, Mccarthy, C, Moore-Kelly, W, Watson, N, Nadama, H, James, C, Sapre, D, Ghosh, R, Baird, J, Cockburn, L, Blackwood, O, Simpson, W, Ahluwalia, V, Barnfield, J, Ben-Gal, O, Bloom, I, Gharatya, A, Khodatars, K, Merchant, N, Moonan, A, Moore, M, Patel, K, Spiers, H, Sundaram, K, Jeong, S, Bishop, S, Black, J, Chadwick, H, Huisman, L, Ingram, H, Martin, L, Metcalfe, M, Sangal, P, Seehra, J, Thatcher, A, Venturini, S, Whitcroft, I, Bate, R, Hobson, C, Adam, A, Redclift, C, Do, J, Poli, F, Batterham, A, Brown, S, Pandya, A, Afzal, Z, Gani, A, Gomaa, A, Hussein, N, Oh, S, Pazhaniappan, N, Sharkey, E, Sivagnanasithiyar, T, Williams, C, Yeung, J, Parekh, J, Clay, W, Pieri, K, Jackson, A, Saxena, A, Gurung, B, Oyebola, T, O'Brien, F, Reilly, S, Cruddas, L, Gurjar, S, Pau, A, Prakash, R, Randhawa, R, Djeugam, B, Gardezi, S, Ul-Hasan, S, Martin-Hernandez, M, Sisley, M, Modi, S, Antakia, R, Archer, J, Chen, L, Eiben, I, Naylor, M, Osei-Bordom, D, Trenear, R, Bannard-Smith, J, Griffiths, N, Patel, B, Saeed, F, Al-Saraff, Z, Elbayouk, A, Soh, Y, Mather, J, Yusuf, Z, Al-Sarraf, Z, Naja, M, Rassool, S, Convill, J, Auty, C, Abdikadir, H, Bennett, M, Church, R, Clements, S, Court, J, Delvi, A, Hubert, J, Macdonald, B, Mansour, F, Patel, R, Perris, R, Small, S, Tam, J, Nikookam, Y, Warsame, A, Pace, C, Kiandee, M, Ridwan, R, Carey, C, Hirri, F, Betts, A, Brown, N, Chong, A, Croitoru, C, Grey, A, Hickland, P, Ho, C, Hollington, D, Mckie, L, Nelson, A, Stewart, H, Eiben, P, Nedham, M, Ali, I, Brown, T, Hunt, C, Joyner, C, Mcalinden, C, Roberts, J, Rogers, D, Thachettu, A, Tyson, N, Vaughan, R, Yasin, T, Powell-Chandler, A, Mcmillan, M, Ling, J, Pendelbury, L, Kerimzade, K, Howard, E, Humayun, S, Wadsworth, O, Roche, C, Andrew, K, Bhamra, N, Mistry, R, Noble, H, Rashed, F, Walker, N, Watson, L, Worsfold, M, Yarham, E, Wood, F, Arshad, A, Barmayehvar, B, Cato, L, Chan-Lam, N, Do, V, Leong, A, Zheleniakova, T, Tan, K, Abdelhameed, F, Haglund, C, Radnaeva, I, Hu, N, Rambhatla, S, Waldron, D, Madahar, P, Malik, S, Coppel, J, Mahmood, R, Nourzaie, R, Sheik-Ali, S, Thomas, A, Alagappan, A, Ashour, R, Bains, H, Diamond, J, Gordon, J, Ibrahim, B, Khalil, M, Mittapalli, D, Neo, Y, Patil, P, Peck, F, Reza, N, Swan, I, Whyte, M, Campbell, A, Meney, L, Kang, C, Chiu, J, Livie, V, Livie, J, Chaudhry, S, Hernon, J, Khawar, H, O'Brien, J, Pullinger, M, Rothnie, K, Ujjal, S, Gorgievska, R, Pooley, G, Shishkin, B, Docherty, J, Southgate, A, Coomes, A, Chaudhry, F, Bhatte, S, Curtis, J, Green, S, Mayer, A, Watkinson, G, Ragavoodoo, A, Mercer, L, Mercer, C, Chapple, K, Hawthorne, T, Khaliq, M, Majkowski, L, Mclauchlan, K, Ng Wei En, B, O'Connor, T, Parton, S, Robinson, S, Saat, M, Shurovi, B, Varatharasasingam, K, Ward, A, Behranwala, K, Bertelli, M, Cohen, J, Duff, F, Fafemi, O, Gupta, R, Manimaran, M, Mayhew, J, Peprah, D, Wong, M, Morice, O, Burzic, A, Cheung, J, Shashidhara, A, Theodoraki, G, Birk, J, Ong, A, Farmer, N, Houghton, C, Kandhari, N, Ladha, D, Mayes, J, Mclennan, F, Panahi, P, Seehra, H, Agrawal, R, Ahmed, I, Ali, S, Birkinshaw, F, Choudhry, M, Gokani, 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S., Toma T., Wadood Q., Yip J., Charalambides M., Clave Llavall A., Williamson E., Bharwada Y., Zearmal S., Evans H., Panikkar M., de la Cruz G., Caplan J., Ainger E., Busti S., Cunliffe L., Flamini T., Gaffing S., Moorcroft C., Peter M., Simpson L., Stokes E., Stott G., Wilson J., York J., Yousaf A., Ruparelia A., Tanvir T., Soare C., Pang Y. L., Trotter J., Zaidi A., Thakrar V., Brown M., Goaman A., Hodgson B., Ijeomah A., Iroegbu U., Kaur G., Lowe C., Mahmood S., Sattar Z., Sen P., Szuman A., Abbas N., Anto N., Bhome R., Eccles L., Elliott J., Hughes E. J., Jones A., Karunatilleke A. S., Knight J. S., Manson C. C. F., Mekhail I., Michaels L., Noton T. M., Okenyi E., Reeves T., Yasin I. H., Pulickal P., Ahmed H., Parnell J., Lennock S., Ford V., Banfield D. A., Harris R., Mason-Apps C., Roe T., Sandhu J., Shafiq N., Stickler E., Tam J. P., Williams L. 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M., Rogers A., Roy C., Rutherford D., Smith F., Zubikarai G., Kok J. Y., Lim D. W. E., Buick T., Boland M., Piya S., Devlin R., Fairfield C. J., George R. J., Rahi M., Al-Khudairi R., Bamford M., Chang M., Cheng J., Hedley C., Joseph R., Mitchell B., Rothwell L., Siddiqui A., Smith J., Taylor K., Wroe Wright O., Zaman S., Hajiev S., Ross T., Baryan H. K., Boyd G., Conchie H., Cox L., Hill N., Krishna K., Lakin F., Scotcher S., Owen M., Crisp E., Thompson C., Alberts J., Asad M., Barraclough J., Marshall D., Wakeford W., Cronbach P., D'Souza F., Gammeri E., Houlton J., Hall M., Kethees A., Patel R., Perera M., Shaid M., Webb E., Saiyed A., Charalambous A., Hollywood J. L., Hammond R. F. L., Beattie S., Chadwick M., El-Taji O., Haddad S., Mann M., Popat K., Rimmer L., Riyat H., Smith H., Matthews J., Mendonca V., Spinty J., Glynn N., Muhammad U., Anderson L., Anandarajah C., Cipparrone M., Desai K., Gao C., Goh E. 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E., Kechagias A., Turunen A., Katunin J., Niskakangas M., Ojakaar A., Venara A., LeNaoures P., Duchalais E., Vignaud T., Frey S., Ricolleau C., Ioannidis A., Konstantinidis M., Antonakopoulos F., Mathioulaki A., Chrysoheris P., Athanasopoulos P. G., Koutserimpas C., Tenconi S. M., Rausei S., Maioli D., Marchionini V., Pasquali S., Simioni A., Farina V., Podda M., Lorenzon L., Tirelli F., Fico V., Santullo F., Belia F., Schaeff V., Otto A., Jakubauskas M., Poskus E., Danys D., Kryzauskas M., Mikalauskas S., Rackauskas R., Drungilas M., Poskus T., Jotautas V., Strupas K., Petrulionis M., van Elst T. R., Abdulrahman Z., Chu M., Fagan P. V. B., Wells C. I., Alagoa Joao A., Soares A., Aparicio D. J., Fragoso M., Guimaraes J., Cruz G., Ribeiro J., Borges da Ponte I., Almeida S., Martins A. R., Juloski J., Cuk V. V., Radulovic R., Milosevic K., Bojicic J., Gencic M., Jankovic U., Jovanovic M., El Kasmy El Kasmi Y., Gomez Jurado M. 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S., White S., Ivanov V., Borisova A., Kuncarova K., Risko J., Ludvik M., Stercz M., Treskon R., Pospisil M., Hlavacova L., Tomanova D., Kolosova B., Sobotkova K., Cha S., Suta Kimle K., Jirankova K., Bujda M., Paclik A., Chrz K., Antonova T., Chodora S., Houdek O., Novicky R., Skalicky A., Farkasova M., Jozaf V., Klail T., Prochazka V., Harbjerg J. L., Enevoldsen M., Hojgaard Pedersen J., Brandsborg S., Amiri S., Brinck S., Jepsen B. N., Hillgaard T. K., Erichsen S. B., Nielsen C. V., Madsen C. P., Bjerke J., Skejo C. D., Aabling R. R., Kjaer M. D., Unbehaun K. P., Mark-Christensen A., Dalsgaard P., Trap A., Jurgens-Lahnstein J., Storm M., Damgaard I., Olawi F., Ehlern F., Raos M., Ravn S., Lycke K. D., Kristensen F. P., Bonnerup K., Brigand C., Dumange E., Gout M., Moehwald C., Prem M., Krupp J., Alhalabi O., Sliwinski S., Gablenz E., Seiboldt T., Beck L., Pohl L. 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E., Sagnotta A., Di Cintio A., Gemini A., Trastulli S., De Luca M., Desiderio J., Gubbiotti F., Campagnaro T., Pedrazzani C., Turri G., Lazzarini E., Conti C., Ruzzenente A., Petrelli F., Marziali I., Mazzocato S., Vergari R., Piazzai F., Kubolli I., Aggiusti A., Paolucci A., Ortenzi M., Gallo G., Clerico G., De Santi G., Bitonti M. F., Trompetto M., Realis Luc A., Papandrea M., Cerra C., Pirillo M., Cravano S., Libri I., Laquatra N., Isabello A., De Luca E., Testa V., Morino M., Mistrangelo M., Sinibaldi G., Angelucci G. P., Scaramuzzo R., Larcinese A., Fioriti C., Picone E., Nardi M., Di Candido F., Spinelli A., Marco M., Bevilacqua M., Maroli A., Colombo F., Cigognini M., Zaffaroni G., Maffioli A., Colombo S., Bondurri A., Sampietro G., Foschi D., Perrone G., Bonati E., Aresu S., Saba A., Biancafarina A., Angelini M., Andolfi E., Miranda E., Scricciolo M., Provenza G., Cavallina G., Frezza B., Fontani A., Malatesti R., Pellicano G. A., Ceccarelli G., Canonico G., Falsetti E., Pagnanelli M., De Nardi P., Rosati R., Marcocci G., Vignali A., Quattromani R., Curletti G., Galleano R., Malerba M., Percivale A., Ghazouani O., Reggiani L., Spirito C., Bini R., de Manzoni Garberini A., Impellizzeri H., Moretto G., Bacchion M., Casaril A., Inama M., Creciun M., Vitali M., Cillara N., Mosino L., Peddis M., Melis S., De Donno G., Aru A. C., Loche G. A., Tutino R., Licari L., Campanella S., Profita G., Falco N., Rotolo G., Venturelli P., De Marco P., Marciano M., Picciariello A., Chetta N., Aquilino F., Papagni V., Coletta D., Cerasari S., Galiffa G., Lapolla P., Del Basso C., Cirillo B., De Toma G., Fazzi K., Bini S., De Padua C., Savino G., Finotti E., Ferrara F., Stella M., Gobatti D., Tamini N., Brenna R., Giani A., Tirotta F., Famularo S., Angrisani M., Ceresoli M., Talamo G., Sucameli F., Gennai A., Moggia E., Bianchi C., Bonfante P., Macina S., Feleppa C., Imperatore M., Berti S., Parini D., Lanari J., Giamundo P., Lo Conte A., Pagano G., Manigrasso M., Danzi M., Amato R., Anastasio L., Mastella F., Basile R., Peltrini R., Marra E., Luglio G., Giglio M., Anoldo P., Vertaldi S., Grimaldi L., Tammaro N., Ripetti V., D'Alessio R., Benvenuto D., Pesce A., Menduni N., Giudicissi R., Zalla T., Baraghini M., Romoli L., Calussi M., Vellei S., Genzano C., Feroci F., Vita M., Giani I., Goldin E., Ciccioli E., Galgano A., Zuin M., Bettella A., Barina A., Vendramin E., Palano G., Schiavone D., Rega D., La Manna V., Migliore G., Aversano A., Fares Bucci A., Belli A., Andriola V., Lafranceschina S., Gordini L., Erdas E., Podda F., Cappellacci F., Salaris C., Sanna S., Marcialis J., Longheu A., Foppa C., Coratti F., Montanelli P., Grandi S., Nelli T., Ben Khaled N., Cammelli F., Ferrini E., Billo M. E., Piccolo G., Romano S., Gaetano P., Pilotta F., Baldassarre L., Birindelli A., D'Errico U., Bianchini S., Ferrari C., Franceschi A., Caristo G., Ballarini Z., Romelli M., Ruggiero S., Percassi A., Milone M., De Rosa M., Pipitone Federico N. S., Molteni B., Magri Piccinini A., Tilocca P. L., Marrosu A. G., Scognamillo F., Pala C., Attene F., Carboni L., Ruggiu M. W., Gabbas G., Sancini G., Roggiani A., Balsamo F., Gori A., Cuicchi D., Vittori L., Piozzi G. N., Tringali D., Bevilacqua E., Panizzo V., Lauretta A., Poillucci G., Mulas S., Simcikas D., Samalavicius N. E., Nutautiene V., Zeromskas P., Jurgaitis J., Aliosin O., Slepavicius A., Eismontas V., Kybransiene M., Portelli L., Cachia C., Cefai C., Youssef Y., Degaetano D., Debono S., Sammut M., Cassar J., Sammut K., Andrejevic P., van Wijnbergen J. W. M., Dinger T. L., ten Doesschate S. F. H., van Dalen A. S. H. M., Looijen R. C., Becker M. A. J., Comert D., Stellingwerf M. E., Abdulrahman N., van den Bos D. D., Gruter A., Vroom Y., Voeten D. M., Feenstra T., de Roy van Zuidewijn D., Hansmann M., Nasimi B., Gerdsen M., Stijns R. C. H., Leow T. Y. S., Penningnieuwland G., Davids J., Medina Feliz J., Kuiper S. Z., Sluijpers N. R. F., van de Pas K. G. H., Pruijssers S. R., Molenaar C. J. L., Thomas G., Farik S., Chen S. Y., Kilpatrick K., Kim D. H., Ong H. I., Elliott B. M., Geneta V. P., Alsadat R., Cherry R., Chapman D. A., Singh N., Clucas A., Gatenby G., Kelly B., Ruppeldt P., McIntosh N. D., Li Y., Wilton S., McLaughlin S. J. P., Kearney J., Sprosen H., Kerckhoffs P., Kandelaki H., Welman D., Coulter J., Morreau M., Li E., Rankin A., Winders J., Skipworth C., Peng S. L., Campbell S., Lim Y. K., Yassaie S. S., Dixon S., Yassaie S., Murray M., Haran C., Koh S., Wilms H., Dalzell F., Tewhaiti-Smith J., Kader T., Yam S. T., Dahya D., Hardie Boys M., Fleischl W., Desmond B., Tan J., Skavysh A., Castro J., Orelhas L., Santos J., Pacheco A., Rocha A. F., Jervis M. 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R., Claassen L., Van Vuuren S., Marx M., Kruger C., Weyers J., Lecler J., Nshalati Salvation M., Mathebula S., Chauke J., Mculu W., Ngwenya Z., Garcia Cardo J., Mora-Guzman I., Sancho Muriel J., de Andres Olabarria U., Casaval Cornejo L., Vicente Rodriguez I., Jimenez Escovar F., Calvo Fernandez M., Portugal Martinez A., Badiola Bergara I., Landaluce Olavarria A., del Pozo Andres E., Muriel P., Mestres N., Cuello E., Merichal M., Sierra J. E., Escoll J., Rufas M., Pinillos A. I., Ortega J., Cerdan C., Jimenez Vinas C., Alconchel F., Martinez Diaz J. M., Ruiz Manzanera J. J., Navarro Barrios A., Rodriguez Pedreno L., Garcia Moreno P., Garcia Gomez M., Rodrigues K., Abrisqueta J., Esteban Sinovas O., Fairen Oro C., Lopez Otero M., Samartin Toimil C., Primo Alvarez J. C., Rodriguez Fernandez L., Paniagua Garcia Senorans M., Figueroa Jimenez S., Livianos Arias-Camison P., Nieto Arranz J. M., Mateos Sexmero M. 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L., Castro Diez L., Mosquera Fernandez C., Fernandez P., Platero Diago J., Veras Lista M., Rifa Terricabras S., Butler Sanz L., Alberch Camprubi E., Rico Ferrandez M., Puig Lao E., De Pablo Miro M., Diaz Padillo A., Padilla Zegarra E. D., Franco M., Martinez A., Forero-Torres A., Alonso-Poza A., Dieguez B., Losada M., Gilsanz C., Alberdi San Roman I., Ramos Jimenez F. A., Perez Ortega A., Trujillo Barbadillo A., Romero Pujana E., Fernandez Illera M. V., Salvador Roses H., Delisau Puig O., Castro A., Codony Bassols C., Fernandes N., Garcia Adamez J., Caula Freixa C., Gomez Romeu N., Merayo Alvarez M., Alonso Batanero E., Cifrian Canales I., Villarejo Campos P., Alberca-Paramo A., Alia Verdejo T., Canete-Manzanares J., Molina-Florez M., Garcia Hernandez L. C., Orozco Nunez S., Suarez-Sanchez M., Martin-Fernandez J., Estaire Gomez M., Lopes Moreira C. C., Gutierrez Rios R. D., Eizaguirre Ubegun M., Novo Sukia I., Uribe Isado M., Ibanez Alda M., Enriquez-Navascues J. M., Uriol Peralta P., Lima Pinto F., Nunez O'Sullivan S., Serrano Navidad M., Vivas Angeles P., Vives Figueras R., Baena Sanfeliu E., Campillo Alonso B., Alberich Prats M., Duran Arrocha J., Cornella Garceso N., Uribe Galeano C., Collado-Roura F., Ripolles-Melchor J., Garcea A., Gomez Facundo H., Troncoso Pereira P., Garcia J. M., Gil A., Giordano H. E., Perez Guarinos C. V., Blaser B., Imadalou L., Piazza G., Teixeira H., Pittet O., Gaspar S., Gagliardi B., Haller M. L., Huot A., Yurdaor S. S., Alim Y. E., Binbuga M., Kurklu O., Ceylan C., Yilmaz S., Calar S. N., Yildirim N., Yavuz G., Biyiklioglu O., Kopac O., Baykan B., Abbasguliyev H., Mutlu V., Mahmoudi Y., Dossa S. A. A., Mizan S. R., Demirtas B., Cavus T., Yuksek A., Karabulut K., Uyanik A., Kargici K., Banaz T., Abdulrahman S. M. F., Yesilsancak M., Yanikoglu E., Karabulut A., Kuyumcu O. F., Kutluk F., Tunc E., Ozmen B. B., Kurtoglu G. K., Sel E. K., Isler V. C., Yilmaz B. S., Adiyaman C., Kara M., Demirkaya H. C., Korkmaz H. 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E., Demirci K., Suresh G., Anbarasan J., Rehman S., Hu E., Timms S., Reynolds W., Hotchkies A., Misra V., Finch B. J., Philip Rajathasan T., Jeddy H., Kyaw H. A., Wong N., Bhahirathan Y., Donaldson C., Sequeira Campos M., Armitage M. N., Hussain A. S., Hardy B., Hassan Serry M. Y., Herron J., Thakrar C., Rojoa D., Yeap B., Iqbal Z., Rojoa D. M., Cabaleiro Barciela C., Ruddy C. M., Lindwe S., Qamar Y., Chuita S., James A., Bugelli M., Chechelnitskaya Y., Bylinski T., Findlay J. M., Skan O., Kind C., Tupper P., Van Rhee C., Honeyman S. I., Menon G., Sloper W., Burford C., Coey J., Akbari K., Whitehead T., Dimitriadis S., Marshall K., Flint E. J., Can B., Cesmeli E., Kus D., Kavar R. C., Cevlik A. D., Cengiz U., Turk E. G., Yilmaz I., Yumurtaci O., Emin A., Girit C., Yildirak M. K., Senyigit E., Guldag A., Soyleyici B., Aytin Y. E., Akay F. E., Iskan N. G., Mutlu B., Sunay A. O., Bell T., Limnatitou D., Gormley S., Taleongpong P., Patel V., Macgregor L., Amini S., Turner C., To N., Laurence N., Green C., Frostick R., Khera R., Povey M., Mahapatra S., Bradbury M., Osunronbi T., Tam L. Y. C., Khanan Kaabneh A., Lawther J., Fisher P., Tribedi T., Moosa A., Ramdin A., McGee F., Flanagan S., Tan Q. J., Anwar H., Clough R., Chrisp B., Cassels J., Cross G. W. V., Refalo A., Hadley R., McTighe A., Farrow F., Brodie A., Davis G., Shah D. R., Bowers C., Ng M. P. E., Wong R. T. W., Maese S., Tandon R., Gray M., Kumar A., Ciurleo C., Nyamali I., Hiremath S., Sinha S., Chowdhary M., Kirupananthan P., Boh Z. Y., Dass S., Soma A., Newton A., Hill M., Shafiq Y., Brkljac M., Martin H., McClarty C., Sanyal S., Alsaif A., Bhopal S., Muneeb F., Page O., Zeb E., Al-Azzawi A., McIntosh J., Vucicevic A., Hughes M., Brooks L., Fanibi B., Dixon M., Njoku P., Morris D., Jobson J., Trussell S., Chowdhury H., Alawode D. O. 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P., Giannella A., Santangelo M., Frangella F., Magagnano D., Liberatore P., Rondelli F., Castagnoli G., Bartoli A., Bellochi R., Spaziani A., Conti D., Poponesi V., Trippetti M., Amicucci S., Tazza G., Procacci P., Giovannini F., Basile E., Moschetta G., Cosmi F., Romeo G., Gasparrini M., Virgilio E., Sparta C., Mura F. A., Barmina M., Lorettu A., Rettaroli C., Mastino G., Ruggiu G. V., Mura G. A., Perrone B. A., De Angelis M., Mereu A., Adamo V., Bianco C., Ricciardiello M., Campanaro C., Panaccio P., Esposito L. M., Di Mola F. F., D'Ascanio F., Pietroletti R., Di Marco F., Amico A., Schembari E., Puglisi S., Tuminello F., Figa F., Caiazzo A., Selvaggi L., Capozzolo A., Braccio B., Truskovs A., Bartnick A., Malcevs E., Machatschek M. J., Alm J., Lapsa S., Delorme M., Zeynalov F., Larnovskis J., Sauka J., Bodrov D., Gailumsis R., Wiemann A. M., Muller N. L., Jelovskis I., Deksnis D., Bauermeister Potts O., Slimbajevs T., Ancans G., Dulskas A., Kuliavas J., Kavaliauskas P., Kavaliauskaite R., te Molder L., Tromp J., Matthee E., Tissen Y. M., Brinkhuis E., de Vries H. S., t Hart E., Beckers K., Bekker Y., Kakar S., van Smaalen T. C., Veen O. C., Dingemans S. A., van den Brink L. C., Vijgen G. H. E. J., van de Voort E. M. F., van der Pool A., van Rest K. L. C., Haak T., Gordinou de Gouberville M. C., Saleh S., Mens M. A., Hoeks E. M., Nieuwenhuizen S., Brandsma A. M., van Praag E. M., Westerduin E., Smit M. P. C. M., van der Lely S. J., de Ruiter A., Ribbers T., Aarts C. A. M., Tulek M. S., de Jonge J., Kocak S., Alqethami H. J., Constansia R., van Elst P. C., Tissink M. W., Azzahhafi J., Bofarid S., Kip M., Saleh W., Franssen S., Boon C. L., Franssen R. J. M., Romaen I., Jense M. T. F., D'Souza J., Pascoe R., Scott A., Stark E., Mulholland K., Lau W. K., Smith B., Adams S. I. B., Shah N., Ling E., Young J., Hawkins R., Jacobson A., Macfater H., Stanfield B., Henderson N., Chuang A., Maskill L., Ker H., Mouldey K., Hu R., Matthews C., Aitken E., Walker M., Winstanley J., Miguel I., Martins J., Cunha M. F., Melo J., Veiga D. N., Rachadell J., Amorim E., Vareda R., Roseira J., Americano M., Correia D., Capella V., Moinhos T., Costa F., Gil I., Morgado J., Varghese S., Boyle E., Aljohmani L., Alexander J., Graziadei V., McCaughey C., Jain A., O'Connor D. B., Ramanayake H., Sabnani R., Colon L. F., Bansal N., Stephens I., Tan R., Hoo M., Doherty G., Fenn S., Mulhare E., Walsh M., Leavey C., Costigan O., Griffin S., Dockry E., Khogali E., Aly A. K., McPhedran R., O'Gorman D., Vermeulen D., Gopaul A., Pentony A. R., Piong C. L., Nossier R., Hanna J., Sabir K., Eow S. Y., Ladak N., Boersma D., Kamath P. J., Soh T. B. W., Dyer A. H., Chee S. Y., Tan I. X. H., Kelliher A., Scanlon K., Adeusi L., Howarth N., McCawley N., O'Neill A., Jones M. R., Saleh R., Singh A., O'Dwyer N., Mana O. C., Gomez H., Riba L., Perez J., Centeno A., Ortega C., Ossola M. E., Camarero E., Martinez Illan M., Aranda Garcia L., Lazaro Cardona M., Montalvo Olmedo C., Izquierdo Moreno A., Cuenca Ramirez A., Margarida A., Pando B., Liquete Marin L., Perez Calle M., Ramos Cordero M. J., Sagredo Cuartango A., Sanchez E., Marcos Rodrigo A., Fernandez A., Curtis C., Bosch M., Triguero D., Bosch Ramirez M., De La Llave Serralvo A., Sanchez M. J., Martin-Borregon P., Quevedo A., Martinez J., Marin J. M., Rodriguez P., Esteban Avendano I., Jimenez Relimpio C., Lancho Lavilla P., Blanco Bartolome I., Gomez Cano I., Blasco Andres C., Abad-Motos A., Marinez-Hurtado E., Salvachua-Fernandez R., Muniesa C., Avelino L., Cholewa H., Sancho-Muriel J., Navasquillo M., Navio A., Abello D., De Jesus M., Alvarez E., Kefleyesus A., Bugmann A., Piotet L. M., Meijers L., Tonchev P., Tamosiunas A., Rottier S. J., Negoi I., Bernado I. 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Ojofeitimi, O, Carroll, L, Hylands, A, Delaugere, L, Reveendran, D, Ahmad, K, Beattie, G, Beatty, M, Campbell, G, Donaldson, G, Graham, S, Holmes, D, Kanabar, S, Liu, H, Mccann, C, Stewart, R, Vara, S, Coulter, C, Ralston, C, Laverty, L, Gallagher, P, Ajibola-Taylor, O, Andah, E, Ani, C, Cabdi, N, Ito, G, Jones, M, Komoriyama, A, Titu, L, Ahmed, A, Yeo, Y, Elliott, D, Bennett, J, Mcnamara, M, Sivarajah, S, Dunmore, C, Basra, M, Gallogly, P, Harinath, G, Leong, S, Pradhan, A, Siddiqui, I, Zaat, S, Ali, A, Galea, M, Looi, W, Ng, J, Farhan-Alanie, M, Aitken, G, Nair, M, Aly, M, Buari, M, Atkin, G, Azizi, A, Cargill, Z, China, Z, Elliot, J, Jebakumar, R, Lam, J, Mudalige, G, Onyerindu, C, Renju, M, Shankar Babu, V, Ahmed, K, Sheikh, Z, Monks, M, Lehmann, J, Rotimi, O, Hussain, M, Joji, N, Lovett, B, Mownah, H, Dwyer-Hemmings, L, Busuttil, A, Powell, J, Hensher, C, Vivian, F, Ali, B, Cresswell, B, Dhillon, A, Dupaguntla, Y, Hungwe, C, Lowe-Zinola, J, Tsang, J, Wcislo, K, Bevan, K, Cardus, 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S., Toma T., Wadood Q., Yip J., Charalambides M., Clave Llavall A., Williamson E., Bharwada Y., Zearmal S., Evans H., Panikkar M., de la Cruz G., Caplan J., Ainger E., Busti S., Cunliffe L., Flamini T., Gaffing S., Moorcroft C., Peter M., Simpson L., Stokes E., Stott G., Wilson J., York J., Yousaf A., Ruparelia A., Tanvir T., Soare C., Pang Y. L., Trotter J., Zaidi A., Thakrar V., Brown M., Goaman A., Hodgson B., Ijeomah A., Iroegbu U., Kaur G., Lowe C., Mahmood S., Sattar Z., Sen P., Szuman A., Abbas N., Anto N., Bhome R., Eccles L., Elliott J., Hughes E. J., Jones A., Karunatilleke A. S., Knight J. S., Manson C. C. F., Mekhail I., Michaels L., Noton T. M., Okenyi E., Reeves T., Yasin I. H., Pulickal P., Ahmed H., Parnell J., Lennock S., Ford V., Banfield D. A., Harris R., Mason-Apps C., Roe T., Sandhu J., Shafiq N., Stickler E., Tam J. P., Williams L. 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M., Rogers A., Roy C., Rutherford D., Smith F., Zubikarai G., Kok J. Y., Lim D. W. E., Buick T., Boland M., Piya S., Devlin R., Fairfield C. J., George R. J., Rahi M., Al-Khudairi R., Bamford M., Chang M., Cheng J., Hedley C., Joseph R., Mitchell B., Rothwell L., Siddiqui A., Smith J., Taylor K., Wroe Wright O., Zaman S., Hajiev S., Ross T., Baryan H. K., Boyd G., Conchie H., Cox L., Hill N., Krishna K., Lakin F., Scotcher S., Owen M., Crisp E., Thompson C., Alberts J., Asad M., Barraclough J., Marshall D., Wakeford W., Cronbach P., D'Souza F., Gammeri E., Houlton J., Hall M., Kethees A., Patel R., Perera M., Shaid M., Webb E., Saiyed A., Charalambous A., Hollywood J. L., Hammond R. F. L., Beattie S., Chadwick M., El-Taji O., Haddad S., Mann M., Popat K., Rimmer L., Riyat H., Smith H., Matthews J., Mendonca V., Spinty J., Glynn N., Muhammad U., Anderson L., Anandarajah C., Cipparrone M., Desai K., Gao C., Goh E. 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E., Kechagias A., Turunen A., Katunin J., Niskakangas M., Ojakaar A., Venara A., LeNaoures P., Duchalais E., Vignaud T., Frey S., Ricolleau C., Ioannidis A., Konstantinidis M., Antonakopoulos F., Mathioulaki A., Chrysoheris P., Athanasopoulos P. G., Koutserimpas C., Tenconi S. M., Rausei S., Maioli D., Marchionini V., Pasquali S., Simioni A., Farina V., Podda M., Lorenzon L., Tirelli F., Fico V., Santullo F., Belia F., Schaeff V., Otto A., Jakubauskas M., Poskus E., Danys D., Kryzauskas M., Mikalauskas S., Rackauskas R., Drungilas M., Poskus T., Jotautas V., Strupas K., Petrulionis M., van Elst T. R., Abdulrahman Z., Chu M., Fagan P. V. B., Wells C. I., Alagoa Joao A., Soares A., Aparicio D. J., Fragoso M., Guimaraes J., Cruz G., Ribeiro J., Borges da Ponte I., Almeida S., Martins A. R., Juloski J., Cuk V. V., Radulovic R., Milosevic K., Bojicic J., Gencic M., Jankovic U., Jovanovic M., El Kasmy El Kasmi Y., Gomez Jurado M. 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S., White S., Ivanov V., Borisova A., Kuncarova K., Risko J., Ludvik M., Stercz M., Treskon R., Pospisil M., Hlavacova L., Tomanova D., Kolosova B., Sobotkova K., Cha S., Suta Kimle K., Jirankova K., Bujda M., Paclik A., Chrz K., Antonova T., Chodora S., Houdek O., Novicky R., Skalicky A., Farkasova M., Jozaf V., Klail T., Prochazka V., Harbjerg J. L., Enevoldsen M., Hojgaard Pedersen J., Brandsborg S., Amiri S., Brinck S., Jepsen B. N., Hillgaard T. K., Erichsen S. B., Nielsen C. V., Madsen C. P., Bjerke J., Skejo C. D., Aabling R. R., Kjaer M. D., Unbehaun K. P., Mark-Christensen A., Dalsgaard P., Trap A., Jurgens-Lahnstein J., Storm M., Damgaard I., Olawi F., Ehlern F., Raos M., Ravn S., Lycke K. D., Kristensen F. P., Bonnerup K., Brigand C., Dumange E., Gout M., Moehwald C., Prem M., Krupp J., Alhalabi O., Sliwinski S., Gablenz E., Seiboldt T., Beck L., Pohl L. 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E., Sagnotta A., Di Cintio A., Gemini A., Trastulli S., De Luca M., Desiderio J., Gubbiotti F., Campagnaro T., Pedrazzani C., Turri G., Lazzarini E., Conti C., Ruzzenente A., Petrelli F., Marziali I., Mazzocato S., Vergari R., Piazzai F., Kubolli I., Aggiusti A., Paolucci A., Ortenzi M., Gallo G., Clerico G., De Santi G., Bitonti M. F., Trompetto M., Realis Luc A., Papandrea M., Cerra C., Pirillo M., Cravano S., Libri I., Laquatra N., Isabello A., De Luca E., Testa V., Morino M., Mistrangelo M., Sinibaldi G., Angelucci G. P., Scaramuzzo R., Larcinese A., Fioriti C., Picone E., Nardi M., Di Candido F., Spinelli A., Marco M., Bevilacqua M., Maroli A., Colombo F., Cigognini M., Zaffaroni G., Maffioli A., Colombo S., Bondurri A., Sampietro G., Foschi D., Perrone G., Bonati E., Aresu S., Saba A., Biancafarina A., Angelini M., Andolfi E., Miranda E., Scricciolo M., Provenza G., Cavallina G., Frezza B., Fontani A., Malatesti R., Pellicano G. A., Ceccarelli G., Canonico G., Falsetti E., Pagnanelli M., De Nardi P., Rosati R., Marcocci G., Vignali A., Quattromani R., Curletti G., Galleano R., Malerba M., Percivale A., Ghazouani O., Reggiani L., Spirito C., Bini R., de Manzoni Garberini A., Impellizzeri H., Moretto G., Bacchion M., Casaril A., Inama M., Creciun M., Vitali M., Cillara N., Mosino L., Peddis M., Melis S., De Donno G., Aru A. C., Loche G. A., Tutino R., Licari L., Campanella S., Profita G., Falco N., Rotolo G., Venturelli P., De Marco P., Marciano M., Picciariello A., Chetta N., Aquilino F., Papagni V., Coletta D., Cerasari S., Galiffa G., Lapolla P., Del Basso C., Cirillo B., De Toma G., Fazzi K., Bini S., De Padua C., Savino G., Finotti E., Ferrara F., Stella M., Gobatti D., Tamini N., Brenna R., Giani A., Tirotta F., Famularo S., Angrisani M., Ceresoli M., Talamo G., Sucameli F., Gennai A., Moggia E., Bianchi C., Bonfante P., Macina S., Feleppa C., Imperatore M., Berti S., Parini D., Lanari J., Giamundo P., Lo Conte A., Pagano G., Manigrasso M., Danzi M., Amato R., Anastasio L., Mastella F., Basile R., Peltrini R., Marra E., Luglio G., Giglio M., Anoldo P., Vertaldi S., Grimaldi L., Tammaro N., Ripetti V., D'Alessio R., Benvenuto D., Pesce A., Menduni N., Giudicissi R., Zalla T., Baraghini M., Romoli L., Calussi M., Vellei S., Genzano C., Feroci F., Vita M., Giani I., Goldin E., Ciccioli E., Galgano A., Zuin M., Bettella A., Barina A., Vendramin E., Palano G., Schiavone D., Rega D., La Manna V., Migliore G., Aversano A., Fares Bucci A., Belli A., Andriola V., Lafranceschina S., Gordini L., Erdas E., Podda F., Cappellacci F., Salaris C., Sanna S., Marcialis J., Longheu A., Foppa C., Coratti F., Montanelli P., Grandi S., Nelli T., Ben Khaled N., Cammelli F., Ferrini E., Billo M. E., Piccolo G., Romano S., Gaetano P., Pilotta F., Baldassarre L., Birindelli A., D'Errico U., Bianchini S., Ferrari C., Franceschi A., Caristo G., Ballarini Z., Romelli M., Ruggiero S., Percassi A., Milone M., De Rosa M., Pipitone Federico N. S., Molteni B., Magri Piccinini A., Tilocca P. L., Marrosu A. G., Scognamillo F., Pala C., Attene F., Carboni L., Ruggiu M. W., Gabbas G., Sancini G., Roggiani A., Balsamo F., Gori A., Cuicchi D., Vittori L., Piozzi G. N., Tringali D., Bevilacqua E., Panizzo V., Lauretta A., Poillucci G., Mulas S., Simcikas D., Samalavicius N. E., Nutautiene V., Zeromskas P., Jurgaitis J., Aliosin O., Slepavicius A., Eismontas V., Kybransiene M., Portelli L., Cachia C., Cefai C., Youssef Y., Degaetano D., Debono S., Sammut M., Cassar J., Sammut K., Andrejevic P., van Wijnbergen J. W. M., Dinger T. L., ten Doesschate S. F. H., van Dalen A. S. H. M., Looijen R. C., Becker M. A. J., Comert D., Stellingwerf M. E., Abdulrahman N., van den Bos D. D., Gruter A., Vroom Y., Voeten D. M., Feenstra T., de Roy van Zuidewijn D., Hansmann M., Nasimi B., Gerdsen M., Stijns R. C. H., Leow T. Y. S., Penningnieuwland G., Davids J., Medina Feliz J., Kuiper S. Z., Sluijpers N. R. F., van de Pas K. G. H., Pruijssers S. R., Molenaar C. J. L., Thomas G., Farik S., Chen S. Y., Kilpatrick K., Kim D. H., Ong H. I., Elliott B. M., Geneta V. P., Alsadat R., Cherry R., Chapman D. A., Singh N., Clucas A., Gatenby G., Kelly B., Ruppeldt P., McIntosh N. D., Li Y., Wilton S., McLaughlin S. J. P., Kearney J., Sprosen H., Kerckhoffs P., Kandelaki H., Welman D., Coulter J., Morreau M., Li E., Rankin A., Winders J., Skipworth C., Peng S. L., Campbell S., Lim Y. K., Yassaie S. S., Dixon S., Yassaie S., Murray M., Haran C., Koh S., Wilms H., Dalzell F., Tewhaiti-Smith J., Kader T., Yam S. T., Dahya D., Hardie Boys M., Fleischl W., Desmond B., Tan J., Skavysh A., Castro J., Orelhas L., Santos J., Pacheco A., Rocha A. F., Jervis M. J., Pedro V., Paixao V., Guerreiro A., Melo D., Laranjeira A., Machado A., Horta V., Rocha-Melo M., Patricio J., Pereira M., Lima R., Cinza A. M., Oliveira J., Velez C., Senhorinho R., Catarino S., Aveiro D., Couto M., Loureiro A. R., Neves-Marques C., Louro T., Morgado M., Ferreira A. S., Alves M., Oliveira N., Lerias R., Estalagem I., Botelho C., Alves-Vale C., Correia J. G., Jardim J. A. M., Domingos S. P., Baiao J. M., Rocha B. S., Lopes N. M. R. O., Jordao D. M., Angelo M. D., Caroco T., Vieira B. N., Silva A. G., Galvao D., Mora A., Bettencourt R., Quintela A. C., Alves D., Dias B., Costa C., Goncalves J. P., Valente P., Freire L., Saraiva R., Moreira M., Peixoto R., Serra M. L., Santos T. C., Lages R. R., Pimentel A., Martins M., Maciel J., Bartolo J., Fidalgo Antunes C., Cabral F., Brito Silva F., Dias Matos A., Santos M., Cunha R., Duarte M., Sousa M., Cunha M., Neves J., Monica I., Oliveira S., Ribeiro H., Ferreira M., Guimaraes N., Azevedo J., Louro H., Queiros T., Castro B., Fonseca S., Carvalho L., Torre A. P., Amado A., Leite M., Romano M., Gomes J. R., Monteiro R. G., Eiro F., Borges F., Simoes J., Botelho P., Cismasiu B., Romano J., Monteiro C., Silva M., Claro M., Almeida P., Cruz A., Vaz Pinto G., Sousa D., Costa Santos D., Silva A., Silva F., Almeida M. R., Parreira R., Faustino A., Medeiros N., Castro R., Soares B., Resendes M., Peyroteo M., Canotilho R., Correia A. M., Martins P. C., Machado N. D., Sa T. C., Bernardes F. M., Saraiva P., Almeida J., Mendes M., Fernandes V., Ribeiro A., Soares D., Capote H., Fialho G., Reia M., Pratas N., Costa J., Morais S., Miranda P., Cunha C., Sousa X., Amado F., Batista A., Seabra J., Praxedes V., Monteiro N., Martins I., Lamas M., Devesa H., Miranda J., Martins S. F., Cavadas D., Silva R., Pina S., Paixao I., Frade S., Guerreiro I., Tome M., Patrocinio S., Costa M., Rosete M., Senaratne R., Kakodkar P., Balasubramanian I., Hogan A., Al-Salihi A., Vyas V., Vedadi A., English C., Mohammed N., Dervan L., Kang S. J., Morrissey E., Compton M., Litvin A., Romanova E., Ponomarev N., Savchenko A., Meszarosova K., Zubowicz M., Suchan P. K., Gerstmeier J., Brazitikou E., Fytrou E., Celik M., Dubovsky M., Schmalenbeck J., Sautter S. C., Ceyran H., Panyko A., Jaich R., Fitchat N., De Lima H., Withey K., Piperidis A., Toyi Y., Nicolaides A., Brooks S., Jaffer T., Sparke A., Van Staden N., McDuling C. R., Claassen L., Van Vuuren S., Marx M., Kruger C., Weyers J., Lecler J., Nshalati Salvation M., Mathebula S., Chauke J., Mculu W., Ngwenya Z., Garcia Cardo J., Mora-Guzman I., Sancho Muriel J., de Andres Olabarria U., Casaval Cornejo L., Vicente Rodriguez I., Jimenez Escovar F., Calvo Fernandez M., Portugal Martinez A., Badiola Bergara I., Landaluce Olavarria A., del Pozo Andres E., Muriel P., Mestres N., Cuello E., Merichal M., Sierra J. E., Escoll J., Rufas M., Pinillos A. I., Ortega J., Cerdan C., Jimenez Vinas C., Alconchel F., Martinez Diaz J. M., Ruiz Manzanera J. J., Navarro Barrios A., Rodriguez Pedreno L., Garcia Moreno P., Garcia Gomez M., Rodrigues K., Abrisqueta J., Esteban Sinovas O., Fairen Oro C., Lopez Otero M., Samartin Toimil C., Primo Alvarez J. C., Rodriguez Fernandez L., Paniagua Garcia Senorans M., Figueroa Jimenez S., Livianos Arias-Camison P., Nieto Arranz J. M., Mateos Sexmero M. J., Diego Alonso E., Gonzalez Amor L., Claramonte Bellmunt O., Martinez Caballero J., Rubio-Perez I., Ramos Martin P., Mate Mate P., Marcano Chavez C., Ayllon H., Aguilar-Martinez M. M., Arroyo A., Segura-Sampedro J. J., Jeri-McFarlane S., Soldevila-Verdeguer C., Pineno-Flores C., Ambrona-Zafra D., Fernandez-Vega L., Gil-Catalan A., Craus-Miguel A., Pujol-Cano N., Sena-Ruiz F., Olmedo Moreno C., Pastor Idoate C., Negre Parra D., Soriano Liebana M. M., Campo Betancourth C. F., Sevila Mico S., Estevez Diz A. M., Martin-Balbuena R., Garcia-Vico A., Roman-Rando A., Sanchez-Galvez M. A., Bersabe-Alonso I. M., Vadillo-Bohorquez A., Bustamante Recuenco C., Calzada M. G., Recuenco C. B., Martin M. C., Licardie Bolanos R. E., Garcia Orozco J. J., Ferrusola Diaz D. A., Garcia Jimenez M. L., Castro Diez L., Mosquera Fernandez C., Fernandez P., Platero Diago J., Veras Lista M., Rifa Terricabras S., Butler Sanz L., Alberch Camprubi E., Rico Ferrandez M., Puig Lao E., De Pablo Miro M., Diaz Padillo A., Padilla Zegarra E. D., Franco M., Martinez A., Forero-Torres A., Alonso-Poza A., Dieguez B., Losada M., Gilsanz C., Alberdi San Roman I., Ramos Jimenez F. A., Perez Ortega A., Trujillo Barbadillo A., Romero Pujana E., Fernandez Illera M. V., Salvador Roses H., Delisau Puig O., Castro A., Codony Bassols C., Fernandes N., Garcia Adamez J., Caula Freixa C., Gomez Romeu N., Merayo Alvarez M., Alonso Batanero E., Cifrian Canales I., Villarejo Campos P., Alberca-Paramo A., Alia Verdejo T., Canete-Manzanares J., Molina-Florez M., Garcia Hernandez L. C., Orozco Nunez S., Suarez-Sanchez M., Martin-Fernandez J., Estaire Gomez M., Lopes Moreira C. C., Gutierrez Rios R. D., Eizaguirre Ubegun M., Novo Sukia I., Uribe Isado M., Ibanez Alda M., Enriquez-Navascues J. M., Uriol Peralta P., Lima Pinto F., Nunez O'Sullivan S., Serrano Navidad M., Vivas Angeles P., Vives Figueras R., Baena Sanfeliu E., Campillo Alonso B., Alberich Prats M., Duran Arrocha J., Cornella Garceso N., Uribe Galeano C., Collado-Roura F., Ripolles-Melchor J., Garcea A., Gomez Facundo H., Troncoso Pereira P., Garcia J. M., Gil A., Giordano H. E., Perez Guarinos C. V., Blaser B., Imadalou L., Piazza G., Teixeira H., Pittet O., Gaspar S., Gagliardi B., Haller M. L., Huot A., Yurdaor S. S., Alim Y. E., Binbuga M., Kurklu O., Ceylan C., Yilmaz S., Calar S. N., Yildirim N., Yavuz G., Biyiklioglu O., Kopac O., Baykan B., Abbasguliyev H., Mutlu V., Mahmoudi Y., Dossa S. A. A., Mizan S. R., Demirtas B., Cavus T., Yuksek A., Karabulut K., Uyanik A., Kargici K., Banaz T., Abdulrahman S. M. F., Yesilsancak M., Yanikoglu E., Karabulut A., Kuyumcu O. F., Kutluk F., Tunc E., Ozmen B. B., Kurtoglu G. K., Sel E. K., Isler V. C., Yilmaz B. S., Adiyaman C., Kara M., Demirkaya H. C., Korkmaz H. K., Pektas A. M., Mutlu D., Tiftik E., Aksoy A. B., Karagoz E., Sabanci R., Tumer S. S., Sarigul L., Aksoy B., Emiroglu B., Mollavelioglu B., Gereklioglu D., Guler M., Toprak S., Afsar H. B., Guler S. E., Alizade E., Aydin T., Yalcinkaya A., Erdem M., Kayacan S., Sahin C., Uysal M., Karakus K., Altiner S., Demirci Z. S., Eren E., Yavas M., Dogan H., Ozoglu F., Mazlum S. S., Yelkenci C., Baran T., Satilmisoglu M., Sahin A. Z., Kilinc A., Isik K., Kocer M. D., Guner B., Islek E. C., Tombul H. B., Boztug C. Y., Tinaz A., Yilmaz M., Karaman Y., Akin F. A., Dansuk S., Bascavus M., Kaya M., Kutlu B., Akyol C., Bilicen G., Yarenci E., Demiroglu Y., Sunal A., Cinar E. N., Tipi O. U., Benli G. E., Tasdelen I., Tura A., Ucar A., Ekci B., Bilgili A. C., Kiraz I. N., Aksoy H., Basak A., Karip B., Uslu O., Seker M. C., Erten V., Memis U., Kocak Z. B., Karapinar Y. E., Fakirullahoglu M., Koseoglu E., Yeni M., Uygur F. A., Kaya Y., Ozen D., Olmez M., Altintas E., Toklu R., Saricicek T., Isik A. E., Demirci K., Suresh G., Anbarasan J., Rehman S., Hu E., Timms S., Reynolds W., Hotchkies A., Misra V., Finch B. J., Philip Rajathasan T., Jeddy H., Kyaw H. A., Wong N., Bhahirathan Y., Donaldson C., Sequeira Campos M., Armitage M. N., Hussain A. S., Hardy B., Hassan Serry M. Y., Herron J., Thakrar C., Rojoa D., Yeap B., Iqbal Z., Rojoa D. M., Cabaleiro Barciela C., Ruddy C. M., Lindwe S., Qamar Y., Chuita S., James A., Bugelli M., Chechelnitskaya Y., Bylinski T., Findlay J. M., Skan O., Kind C., Tupper P., Van Rhee C., Honeyman S. I., Menon G., Sloper W., Burford C., Coey J., Akbari K., Whitehead T., Dimitriadis S., Marshall K., Flint E. J., Can B., Cesmeli E., Kus D., Kavar R. C., Cevlik A. D., Cengiz U., Turk E. G., Yilmaz I., Yumurtaci O., Emin A., Girit C., Yildirak M. K., Senyigit E., Guldag A., Soyleyici B., Aytin Y. E., Akay F. E., Iskan N. G., Mutlu B., Sunay A. O., Bell T., Limnatitou D., Gormley S., Taleongpong P., Patel V., Macgregor L., Amini S., Turner C., To N., Laurence N., Green C., Frostick R., Khera R., Povey M., Mahapatra S., Bradbury M., Osunronbi T., Tam L. Y. C., Khanan Kaabneh A., Lawther J., Fisher P., Tribedi T., Moosa A., Ramdin A., McGee F., Flanagan S., Tan Q. J., Anwar H., Clough R., Chrisp B., Cassels J., Cross G. W. V., Refalo A., Hadley R., McTighe A., Farrow F., Brodie A., Davis G., Shah D. R., Bowers C., Ng M. P. E., Wong R. T. W., Maese S., Tandon R., Gray M., Kumar A., Ciurleo C., Nyamali I., Hiremath S., Sinha S., Chowdhary M., Kirupananthan P., Boh Z. Y., Dass S., Soma A., Newton A., Hill M., Shafiq Y., Brkljac M., Martin H., McClarty C., Sanyal S., Alsaif A., Bhopal S., Muneeb F., Page O., Zeb E., Al-Azzawi A., McIntosh J., Vucicevic A., Hughes M., Brooks L., Fanibi B., Dixon M., Njoku P., Morris D., Jobson J., Trussell S., Chowdhury H., Alawode D. O. T., Udayachandran V., Alsoof D., Ekert J., Joseph N., Zulkefley N., Hunt G., Christodoulou T., Wright O., Soman S., Jamal M., Beqiri S., Borgas P., Pereira F., Browne S., Yiu J., Dworkin A., Mak J., Patrawala S., Milinkovic N., Schofield R., Chauhan M., Hartley L., Hind J., Heybourne A., Morgan H., Wickstone C., Panagiotou D., O'Connell E., Dean K., Iqbal R., Walsh L., Yu N., Rana N., Massie E., Foong J., Lee Y. J., Mijalkov D., Wells A., Bull N., Ajmera A., Warburton T., Morgan S., Mahmoud A., Schachtel M., Mikhail B., Fomin I., Mekaeil B., Jun H. J. S., Hengpoonthana R., Childs S., Ridgway S., Blefari N. D. A., Tam H., Puchalski N., Ngai C., Mackenzie J., Johnson N., Holmes M., Zuzek R., Saluja T., Gould T., Goh Y. K., Selvaraj T., Horne D., Borrow J. L., Campbell C., Cousins G., Jackson L., Maheepala K., Zhao S., Holden E., Tutt L., Thompson B., Collins H., Louie F., Buckland B., Smith D., Chong C., Chua T. H., Nayak C., Redmond J., Tan R. R., Gramlick M., Teh J. S., Ng S. Y., Britten-Jones P., Mohd Rosli R., Pham H. D. V., Harris M., Salibasic M., Pavlov V., Paycheva T., Lyulenina E., Kolev N., Boev B., Nguen D., Mitkov Y., Mitkov E., Vladova P., Dimitrov V., Gabarski A., Feradova H., Mladenov T., Pos M., Adel A., Sotona O., Bartos M., Amjad T., Maly O., Berec S., Hanusova M., Hurny M., Orhalmi J., Sorensen J. S., Chanut F., Magnin J., Schoning L., Simon S. C. S., Galata C., Karampinis I., Thawel T., Seckler A. M., Kerem C., Durdevic S., Herrle F., Artioli E., Giaccari S., Nevoso V., Schimera A., Marino S., Resta G., Ongaro D., Baronio G., Raimondo S., Casiraghi S., Salvadori R., Armellini A., Vulcano I., Bertilone E., Pintabona G., Viscosi F., Mazzeo C., Olivieri M., Belluco C., Antona A. D., Basso S., Frattalone M., Marino F., Carbone F., Incollingo P., Romano F. M., Anania M., Pulighe F., Cruccu A., Murru M. L., Massaiu C., Balestra F., Pazzona M., De Nisco C., Gusai G. P., Giannella A., Santangelo M., Frangella F., Magagnano D., Liberatore P., Rondelli F., Castagnoli G., Bartoli A., Bellochi R., Spaziani A., Conti D., Poponesi V., Trippetti M., Amicucci S., Tazza G., Procacci P., Giovannini F., Basile E., Moschetta G., Cosmi F., Romeo G., Gasparrini M., Virgilio E., Sparta C., Mura F. A., Barmina M., Lorettu A., Rettaroli C., Mastino G., Ruggiu G. V., Mura G. A., Perrone B. A., De Angelis M., Mereu A., Adamo V., Bianco C., Ricciardiello M., Campanaro C., Panaccio P., Esposito L. M., Di Mola F. F., D'Ascanio F., Pietroletti R., Di Marco F., Amico A., Schembari E., Puglisi S., Tuminello F., Figa F., Caiazzo A., Selvaggi L., Capozzolo A., Braccio B., Truskovs A., Bartnick A., Malcevs E., Machatschek M. J., Alm J., Lapsa S., Delorme M., Zeynalov F., Larnovskis J., Sauka J., Bodrov D., Gailumsis R., Wiemann A. M., Muller N. L., Jelovskis I., Deksnis D., Bauermeister Potts O., Slimbajevs T., Ancans G., Dulskas A., Kuliavas J., Kavaliauskas P., Kavaliauskaite R., te Molder L., Tromp J., Matthee E., Tissen Y. M., Brinkhuis E., de Vries H. S., t Hart E., Beckers K., Bekker Y., Kakar S., van Smaalen T. C., Veen O. C., Dingemans S. A., van den Brink L. C., Vijgen G. H. E. J., van de Voort E. M. F., van der Pool A., van Rest K. L. C., Haak T., Gordinou de Gouberville M. C., Saleh S., Mens M. A., Hoeks E. M., Nieuwenhuizen S., Brandsma A. M., van Praag E. M., Westerduin E., Smit M. P. C. M., van der Lely S. J., de Ruiter A., Ribbers T., Aarts C. A. M., Tulek M. S., de Jonge J., Kocak S., Alqethami H. J., Constansia R., van Elst P. C., Tissink M. W., Azzahhafi J., Bofarid S., Kip M., Saleh W., Franssen S., Boon C. L., Franssen R. J. M., Romaen I., Jense M. T. F., D'Souza J., Pascoe R., Scott A., Stark E., Mulholland K., Lau W. K., Smith B., Adams S. I. B., Shah N., Ling E., Young J., Hawkins R., Jacobson A., Macfater H., Stanfield B., Henderson N., Chuang A., Maskill L., Ker H., Mouldey K., Hu R., Matthews C., Aitken E., Walker M., Winstanley J., Miguel I., Martins J., Cunha M. F., Melo J., Veiga D. N., Rachadell J., Amorim E., Vareda R., Roseira J., Americano M., Correia D., Capella V., Moinhos T., Costa F., Gil I., Morgado J., Varghese S., Boyle E., Aljohmani L., Alexander J., Graziadei V., McCaughey C., Jain A., O'Connor D. B., Ramanayake H., Sabnani R., Colon L. F., Bansal N., Stephens I., Tan R., Hoo M., Doherty G., Fenn S., Mulhare E., Walsh M., Leavey C., Costigan O., Griffin S., Dockry E., Khogali E., Aly A. K., McPhedran R., O'Gorman D., Vermeulen D., Gopaul A., Pentony A. R., Piong C. L., Nossier R., Hanna J., Sabir K., Eow S. Y., Ladak N., Boersma D., Kamath P. J., Soh T. B. W., Dyer A. H., Chee S. Y., Tan I. X. H., Kelliher A., Scanlon K., Adeusi L., Howarth N., McCawley N., O'Neill A., Jones M. R., Saleh R., Singh A., O'Dwyer N., Mana O. C., Gomez H., Riba L., Perez J., Centeno A., Ortega C., Ossola M. E., Camarero E., Martinez Illan M., Aranda Garcia L., Lazaro Cardona M., Montalvo Olmedo C., Izquierdo Moreno A., Cuenca Ramirez A., Margarida A., Pando B., Liquete Marin L., Perez Calle M., Ramos Cordero M. J., Sagredo Cuartango A., Sanchez E., Marcos Rodrigo A., Fernandez A., Curtis C., Bosch M., Triguero D., Bosch Ramirez M., De La Llave Serralvo A., Sanchez M. J., Martin-Borregon P., Quevedo A., Martinez J., Marin J. M., Rodriguez P., Esteban Avendano I., Jimenez Relimpio C., Lancho Lavilla P., Blanco Bartolome I., Gomez Cano I., Blasco Andres C., Abad-Motos A., Marinez-Hurtado E., Salvachua-Fernandez R., Muniesa C., Avelino L., Cholewa H., Sancho-Muriel J., Navasquillo M., Navio A., Abello D., De Jesus M., Alvarez E., Kefleyesus A., Bugmann A., Piotet L. M., Meijers L., Tonchev P., Tamosiunas A., Rottier S. J., Negoi I., Bernado I. R., and Eftychiou S. more...
- Abstract
Background: Postoperative acute kidney injury (AKI) is a common complication of major gastrointestinal surgery with an impact on short- and long-term survival. No validated system for risk stratification exists for this patient group. This study aimed to validate externally a prognostic model for AKI after major gastrointestinal surgery in two multicentre cohort studies. Methods: The Outcomes After Kidney injury in Surgery (OAKS) prognostic model was developed to predict risk of AKI in the 7 days after surgery using six routine datapoints (age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker). Validation was performed within two independent cohorts: a prospective multicentre, international study (‘IMAGINE’) of patients undergoing elective colorectal surgery (2018); and a retrospective regional cohort study (‘Tayside’) in major abdominal surgery (2011–2015). Multivariable logistic regression was used to predict risk of AKI, with multiple imputation used to account for data missing at random. Prognostic accuracy was assessed for patients at high risk (greater than 20 per cent) of postoperative AKI. Results: In the validation cohorts, 12.9 per cent of patients (661 of 5106) in IMAGINE and 14.7 per cent (106 of 719 patients) in Tayside developed 7-day postoperative AKI. Using the OAKS model, 558 patients (9.6 per cent) were classified as high risk. Less than 10 per cent of patients classified as low-risk developed AKI in either cohort (negative predictive value greater than 0.9). Upon external validation, the OAKS model retained an area under the receiver operating characteristic (AUC) curve of range 0.655–0.681 (Tayside 95 per cent c.i. 0.596 to 0.714; IMAGINE 95 per cent c.i. 0.659 to 0.703), sensitivity values range 0.323–0.352 (IMAGINE 95 per cent c.i. 0.281 to 0.368; Tayside 95 per cent c.i. 0.253 to 0.461), and specif more...
- Published
- 2022
8. Carob seed germ meal in diets for meagre (Argyrosomus regius) juveniles: Growth, digestive enzymes, intermediary metabolism, liver and gut histology
- Author
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Couto, A., Barroso, C., Guerreiro, I., Pousão-Ferreira, P., Matos, E., Peres, H., Oliva-Teles, A., and Enes, P.
- Published
- 2016
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9. Validation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery
- Author
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Ahmed, W. U. R., Bhatia, S., Mclean, K. A., Khaw, R., Baker, D., Kamarajah, S. K., Bell, S., Nepogodiev, D., Harrison, E. M., Glasbey, J. C., Borakati, A., Burke, J., Drake, T. M., Bath, M. F., Claireaux, H. A., Gundogan, B., Mohan, M., Deekonda, P., Kong, C., Joyce, H., Mcnamee, L., Woin, E., Khatri, C., Fitzgerald, J. E., Bhangu, A., Arulkumaran, N., Duthie, F., Hughes, J., Pinkney, T. D., Prowle, J., Richards, T., Thomas, M., Blanco-Colino, R., Chapman, S. J., Pata, F., Pellino, G., Sgr??, A., Soares, A., van Elst, T., Van Straten, S., Knowles, C. H., Dynes, K., Patel, M., Patel, P., Wigley, C., Suresh, R., Shaw, A., Klimach, S., Jull, P., Evans, D., Preece, R., Ibrahim, I., Manikavasagar, V., Smith, R., Brown, F. S., Teo, R., Sim, D. P. Y., Logan, A. E., Barai, I., Amin, H., Suresh, S., Sethi, R., Gul, W., Bolton, W., Corbridge, O., Horne, L., Attalla, M., Morley, R., Robinson, C., Hoskins, T., Mcallister, R., Lee, S., Dennis, Y., Nixon, G., Heywood, E., Wilson, H., Ng, L., Samaraweera, S., Mills, A., Doherty, C., Belchos, J., Phan, V., Lim, M., Miller, F. A., Chouari, T., Gardner, T., Goergen, N., Hayes, J. D. B., Macleod, C. S., Mccormack, R., Mckinley, A., Mckinstry, S., Milligan, W., Ooi, L., Rafiq, N. M., Sammut, T., Sinclair, E., Smith, M., Wong, J., Ablett, A. D., Tie-Gill, T., Ramsay, G., De Paola, L., Mcguckin, S., Alshakhs, A., Ahmeidat, A., Francis, A. A., Baker, C., Boulton, A. P. R., Collins, J., Copley, H. C., Fearnhead, N., Fox, H., Mah, T., Mckenna, J., Naruka, V., Nigam, N., Nourallah, B., Perera, S., Qureshi, A., Saggar, S., Sun, L., Wang, X., Yang, D. D., Ali, Z., Mullarkey, L., Walshe, R., Lewis, E., Berry, B., Moneim, J., Mookerjee, S., Al-hadithi, A., Caroll, P., Doyle, C., Elangovan, S., Falamarzi, A., Gascon Perai, K., Greenan, E., Jain, D., Lang-Orsini, M., Lim, S., O'Byrne, L., Ridgway, P., Van der Laan, S., Arthur, J., Barclay, J., Bradley, P., Edwin, C., Finch, E., Hayashi, E., Hopkins, M., Kelly, D., Kelly, M., Mccartan, N., Ormrod, A., Pakenham, A., Christy, S., Hayward, J., Hitchen, C., Kishore, A., Martins, T., Philomen, J., Rao, R., Rickards, C., Burns, N., Copeland, M., Durand, C., Dyal, A., Ghaffar, A., Gidwani, A., Grant, M., Gribbon, C., Gruhn, A., Leer, M., Ojofeitimi, O., Carroll, L., Hylands, A., Delaugere, L. P., Reveendran, D., Ahmad, K., Beattie, G., Beatty, M., Campbell, G., Donaldson, G., Graham, S., Holmes, D., Kanabar, S., Liu, H., Mccann, C., Stewart, R., Vara, S., Coulter, C., Ralston, C., Laverty, L., Gallagher, P., Ajibola-Taylor, O., Andah, E. J. E., Ani, C., Cabdi, N. M. O., Ito, G., Jones, M., Komoriyama, A., Titu, L., Ahmed, A., Yeo, Y. Q., Elliott, D., Bennett, J., Mcnamara, M., Sivarajah, S., Dunmore, C., Basra, M., Gallogly, P., Harinath, G., Leong, S. H., Pradhan, A., Siddiqui, I., Zaat, S., Ali, A., Galea, M., Looi, W. L., J. C. K., Ng, Farhan-Alanie, M. M. H., Aitken, G., Nair, M., Aly, M. H., Buari, M., Atkin, G., Azizi, A., Cargill, Z., China, Z., Elliot, J., Jebakumar, R., Lam, J., Mudalige, G., Onyerindu, C., Renju, M., Shankar Babu, V., Ahmed, K., Sheikh, Z., Monks, M., Lehmann, J., Rotimi, O., Hussain, M., Joji, N., Lovett, B., Mownah, H., Dwyer-Hemmings, L., Busuttil, A., Powell, J., Hensher, C., Vivian, F., Ali, B., Cresswell, B., Dhillon, A. K., Dupaguntla, Y. S., Hungwe, C., Lowe-Zinola, J. D., Tsang, J. C. H., Wcislo, K., Bevan, K., Cardus, C., Duggal, A., Hossain, S., Mchugh, M., Scott, M., Millar, Z., Hirosue, S., Ogunmwonyi, I., Nakakande, D., Chan, F., Evans, R., Gurung, E., Haughey, B., Jacob-Ramsdale, B., Kerr, M., Lee, J., Mccann, E., O'Boyle, K., Reid, N., Kwek, I., Gaze, H., Nirmalanantha, A., Bin Amran, M. A., Foulkes, A., Jones, N., Lau, I. S. F., Hayat, F., Hodgson, S., Johnston, R., Jones, W., Khan, M., Linn, T., Long, S., Seetharam, P., Shaman, S., Smart, B., Pillai, S., Khoury, G., Powell, T., Maleyko, I., Sangheli, A., Ransome, M., Isse, M., Aromolaran, O., Bholah, H., Anilkumar, A., Davies, J., Griffith, J., Hughes, B., Islam, Y., Kidanu, D., Mushaini, N., Qamar, I., Robinson, H., Schramm, M., Yan Tan, C., Murray, V., Theocharidou, L., Malik, T., Janmohamed, I., Carhart, B., Khan, A., Apperley, H., Billyard, C., Blazeby, J. M., Cannon, S. P., Carse, S., G??pfert, A., Loizidou, A., Parkin, J., Sanders, E., Sharma, S., Slade, G., Telfer, R., Whybrow Huppatz, I., Worley, E., Asif, A., Hullait, R., Quinn, P., Rylance, A., Butt, S., Leathes, J., Chandramoorthy, L., Friend, C., Harris, L., Jain, P., Karim, M. J., Killington, K., Mcgillicuddy, J., Rafferty, C., Rahunathan, N., Rayne, T., Varathan, Y., Verma, N., Zanichelli, D., Arneill, M., Brown, F., Campbell, B., Crozier, L., Henry, J., Mccusker, C., Prabakaran, P., Wilson, R., Karelia, S., Clements, J. M., Rainey, M., Asif, U., Connor, M., Dindyal, S., Math, N., Pagarkar, A., Saleem, H., Seth, I., Standfield, N., Swartbol, T., Adamson, R., Choi, J. E., El Tokhy, O., Ho, W., Javaid, N. R., Mehdi, A. S., Menon, D., Plumptre, I., Sturrock, S., Turner, J., Warren, O., Joshi, N., Rahman, A., Gallagher, M., Crane, E., Ferris, B., Gadsby, C., Smallwood, J., Vipond, M., Wilson, V., Amarnath, T., Doshi, A., Gregory, C., Kandiah, K., Powell, B., Spoor, H., Toh, C., Vizor, R., Rebuffa, N., Abdelgalil, R., Siaw Yen Lai, R., Smith, E., Common, M., Dunleavy, K., Harris, S., Luo, C., Mesbah, Z., Prem Kumar, A., Redmond, A., Skulsky, S., Walsh, T., Daly, D., Deery, L., Epanomeritakis, E., Harty, M., Kane, D., Khan, K., Mackey, R., Mcconville, J., Mcginnity, K., Wong, H. L., Ang, A., Kee, J. Y., Leung, E., Norman, S., Palaniappan, S. V., Partha Sarathy, P., Yeoh, T., Frost, J., Hazeldine, P., Jones, L., Karbowiak, M., Macdonald, C., Mutarambirwa, A., Omotade, A., Runkel, M., Ryan, G., Sawers, N., Searle, C., Vig, S., Hlukha, L., Pike, G., Kamel, F., Thakkar, R., Mcauliffe, O., Ahmad, A., Mcgartland, R., Sim, R., Song, A., Wayman, J., Brown, R., Chang, L. H., Concannon, K., Crilly, C., Arnold, T. J., Burgin, A., Cadden, F., Choy, C. H., Coleman, M., Lim, D., Luk, J., Mahankali-Rao, P., Prudence-Taylor, A. J., Ramakrishnan, D., Russell, J., Fawole, A., Gohil, J., Green, B., Hussain, A., Mcmenamin, L., Tang, M., Azmi, F., Benchetrit, S., Cope, T., Haque, A., Harlinska, A., Holdsworth, R., Ivo, T., Martin, J., Nisar, T., Patel, A., Sasapu, K., Trevett, J., Vernet, G., Aamir, A., Bird, C., Durham-Hall, A., Gibson, W., Hartley, J., May, N., Maynard, V., Goble, M., Downs, E., Wheldon, L., Baggus, E., Mandal, A., Nayeem, A., Ahmed, S., Fradley, W., Johnson, S., McDonald Wood, C., O'Brien, M., Orbell, J., Stringfellow, T. D., Tenters, F., Tresidder, S., Wilson, C., Gallagher, S., Criswell, T., Ward, J., Mukkavilli, A., Stubbs, B., Fordyce, W., Cheung, W., Grant, A., Tod, N., Yi Tew, Z., Suchdev, N., Wei Lim, S., Bews-Hair, M., Lim, Z. H., Lim, S. W., Vella-Baldacchino, M., Auckburally, S., Chopada, A., Easdon, S., Goodson, R., Mccurdie, F., Narouz, M., Radford, A., Rea, E., Taylor, O., Yu, T., Sookramanien, S. R., Chan, A., Bointas, G., Alfa-Wali, M., Amani, L., Auluck, I., Bruce, P., Emberton, J., Kumar, R., Lagzouli, N., Mehta, A., Murtaza, A., Raja, M., Dennahy, I. S., Frew, K., Given, A., Y. Y., He, Karim, M. A., Macdonald, E., Mcdonald, E., Mcvinnie, D., S. K., Ng, Pettit, A., Berthaume-Hawkins, S. D., Charnley, R., Fenton, K., Jones, D., Murphy, C., J. Q., Ng, Reehal, R., Seraj, S. S., Shang, E., Tonks, A., White, P., Yeo, A., Paul, M., Ward, K. L., Bagnall, M., Chong, P., Gabriel, R., Patel, N., Richardson, E., Symons, L., Aubrey-Jones, D., Dawood, S., Dobrzynska, M., Faulkner, S., Griffiths, H., Mahmood, F., Perry, M., Power, A., Simpson, R., Pherwani, S. A., Wang, K., Mitchell, L., Heyworth, J., Ayyar, S., Brobbey, P., Burrows, A., Elder, P., Ganyani, R., Horseman, C., Hurst, P., Mann, H., Marimuthu, K., Mcbride, S., Pilsworth, E., Powers, N., Stanier, P., Obukofe, R., Polson, R., Mason, D., Mackenzie, E., Innes, R., Kersey, T., Kopczynska, M., Langasco, N., Rajagopal, R., Russell, C., Doyle, N., Habib, Z., Zardab, M., Sartaj, F., Farooq, H., Tabibi, M., Imam, L., Atkins, B., Beasley, W., Cheng Lim, Z., Gill, A., Li Ang, H., Williams, H., Yogeswara, T., Drury, D. J., James, S. J., Barnett, R., Teasdale, A. B., Richardson, E. T. J., Thomas, D. A., Williams, R. L., Najabat-Lattif, H. F., Akram, B., Carter, R., Fam, M., Fong, J., Latter, J., Long, M., Mackinnon, S., Mckenzie, C., Osmanska, J., Raghuvir, V., Shafi, A., Tsang, K., Walker, L., Cahya, E., Lou, G., Coyle, M., Homyer, K., Zhu, L. Y., Woods, M., Bountra, K., Coldicutt, O., Fletcher, D., Hudson, S., Iqbal, S., Lopez Bernal, T., Martin, J. W. B., Moss-Lawton, F., Suchett-Kay, I., Chang, J., O'Callaghan, H., Suchett-Kaye, I., Mihailidis, T. H., Cardwell, A., Edgerton, K., Laws, J., Rai, A., Robinson, K., Waite, K., Youssef, H., Alawattegama, H., Seite, E., Barrett, A., Riordan, E., Lam, W., Dowdeswell, M., Mulvenna, C., Knight, C., Koo, P. Y., Lazarou, A., Stanger, S., Thorn, C., Triniman, M. C., Netke, T., Awokoya, O., Gurowich, L., Dhera, K., Hossaini, S., Botha, A., Boyles, L., Cumming, S., Deepak, S., Ezzat, A., Fowler, A. J., Gwozdz, A. M., Hussain, S. F., Khan, S., Li, H., Lu Morrell, B., Neville, J., Nitiahpapand, R., Pickering, O., Sagoo, H., Sharma, E., Welsh, K., Williams, L., Hayat, S., Tincknell, L., Spazzapan, M., Teeling, F., Sysum, K., Denley, S., Latter, M., Agarwal, M., Al-Saadi, N., Bhambra, R., Gupta, A., Jawad, Z. A. R., Jiao, L. R., Mahir, G., Singagireson, S., Thoms, B. L., Tseu, B., Wei, R., Yang, N., Britton, N., Leinhardt, D., Mahfooz, M., Palkhi, A., Price, M., Sheikh, S., Barker, M., Bowley, D., Cant, M., Datta, U., Farooqi, M., Lee, A., Morley, G., Naushad Amin, M., Parry, A., Patel, S., Strang, S., Yoganayagam, N., Guruswamy, M., Beedham, W., Brazier, E., Elghobashy, M., Bajaj, M., Etel, E., Adlan, A., Chandramoorthy, S., Choudhary, Y., Das, K., Feldman, M., France, B., Grace, R., Puddy, H., Soor, P., Kisiel, A., Woodmass, M., Hayden, H., Ali, Y., Husain, S., Ali, M., Dhillon, P., Faraj, A., Gerard, L., Glover, M., Imran, H., Kim, S., Patrick, Y., Peto, J., Prabhudesai, A., Tang, A., Vadgama, N., Dhaliwal, R., Ecclestone, T., Harris, A., Ong, D., Patel, D., Philp, C., Stewart, E., Wang, L., Wong, E., Xu, Y., Ashaye, T., Fozard, T., Galloway, F., Kaptanis, S., Mistry, P., Nguyen, T., Olagbaiye, F., Osman, M., Philip, Z., Rembacken, R., Tayeh, S., Theodoropoulou, K., Liu, F. Y., Arnold, A., Pedersen, A. C., Cunha, P., Ahmed, M., Al Zawawi, S., Kudva, V., Herman, A., Lau, J., Saha, A., Trotter, M., Miscampbell, M., Robinson, A. V., Johnston, J., Dharni, A., Lamb, S., Westerman, T., Adeleye, O., Cave, D., Gunwa, T., Magalh??es, J., Makwana, S., Mason, R., Parish, M., Regan, H., Renwick, P., Roberts, G., Salekin, D., Sivakumar, C., Tariq, A., Liew, I., Mcdade, A., Stewart, D., Evans, E., Campbell, L., Gillespie, M., Cheong, C. M., Hague, M., Hudson-Peacock, N., Jackson, C. E. S., James, F., Pitt, J., Walker, E. Y., Kulathevanayagam, K., Varghese, A., Ike, S. I., Aftab, R., Ang, J. J., Anwar, S., Battle, J., Budd, E., Chui, J., Crook, H., Davies, P., Easby, S., Hackney, E., Ho, B., Imam, S. Z., Rammell, J., Chu, T. S. M., Baljer, B., Mogg, J. A. W., Rai, P., Andrews, H., Perry, C., Schinle, P., Ahmed, P., Aquilina, T., Balai, E., Church, M., Cumber, E., Curtis, A., Davies, G., Dumann, E., Greenhalgh, S., Kim, P., King, S., Metcalfe, K. H. M., Passby, L., Redgrave, N., Soonawalla, Z., Waters, S., Zornoza, A., Claireaux, H., Williams, M., Smillie, R., Goetz, J., Appleby, E., Fadipe, T., Vaughan-Burleigh, S., Davies, R., Gulzar, I., Hole, J., Hull, K., Ishaq, H., Karaj, J., Kelkar, A., Love, E., Thakrar, D., Vine, M., Waterman, A., James, P., Puri, G., Hussain, P., Flather, R., Cutler, A., Pathak, S., Sheldon, J., Collicott, T., al-Ausi, M., Ko, M., Dib, N. P., Francis, N., Hanson, M., Ingleton, R., Sadanand, K. S., Sukirthan, N., Mondal, A., Jovaisaite, A., Shah, S. M., Khalid, N., Gutmann, D., Davison, S., Alame, Y. J., Syed, L., Owen, W. J., Arnell, S., Ball, M., Bassam, N., Beghal, G., Chang, A., Dawe, V., George, A., Huq, T., Ikram, B., Kanapeckaite, L., Ramjas, D., Rushd, A., Sait, S., Serry, M., Yardimci, E., Kalderon, R., Ahsan, S. D., Anthony-Uzoeto, U., Macleod Hall, C., Zheng, S., Wynter, K., Capella, S., Chenciner, L., Episkopos, C., Karam, E., Mccarthy, C., Moore-Kelly, W., Watson, N., Nadama, H. H., James, C., Sapre, D., Ghosh, R., Baird, J., Cockburn, L., Blackwood, O., Simpson, W., Ahluwalia, V., Barnfield, J., Ben-Gal, O., Bloom, I., Gharatya, A., Khodatars, K., Merchant, N., Moonan, A., Moore, M., Patel, K., Spiers, H., Sundaram, K., Jeong, S., Bishop, S., Black, J., Chadwick, H., Huisman, L., Ingram, H., Martin, L., Metcalfe, M., Sangal, P., Seehra, J., Thatcher, A., Venturini, S., Whitcroft, I., Bate, R., Hobson, C., Adam, A. H., Redclift, C., Do, J., Poli, F., Batterham, A., Brown, S., Pandya, A., Afzal, Z., Gani, A., Gomaa, A., Hussein, N., S. Y., Oh, Pazhaniappan, N., Sharkey, E., Sivagnanasithiyar, T., Williams, C., Yeung, J., Parekh, J. N., Clay, W., Pieri, K., Jackson, A., Saxena, A., Gurung, B., Oyebola, T., O'Brien, F., Reilly, S., Cruddas, L., Gurjar, S., Pau, A., Prakash, R., Randhawa, R., Djeugam, B., Gardezi, S., Ul-Hasan, S., Martin-Hernandez, M. P., Sisley, M., Modi, S., Antakia, R., Archer, J., Chen, L., Eiben, I., Naylor, M., Osei-Bordom, D., Trenear, R., Bannard-Smith, J., Griffiths, N., Patel, B. Y., Saeed, F., Al-Saraff, Z., Elbayouk, A., Soh, Y. J., Mather, J., Yusuf, Z., Al-Sarraf, Z., Naja, M., Rassool, S. B., Convill, J., Auty, C., Abdikadir, H., Bennett, M., Church, R., Clements, S. E., Court, J., Delvi, A., Hubert, J., Macdonald, B., Mansour, F., Patel, R. R., Perris, R., Small, S., Tam, J. P. H., Nikookam, Y., Warsame, A., Pace, C., Kiandee, M., Ridwan, R., Carey, C., Hirri, F., Betts, A., Brown, N., Chong, A., Croitoru, C., Grey, A., Hickland, P., Ho, C., Hollington, D., Mckie, L., Nelson, A. R., Stewart, H., Eiben, P., Nedham, M., Ali, I., Brown, T., Hunt, C., Joyner, C., Mcalinden, C., Roberts, J., Rogers, D., Thachettu, A., Tyson, N., Vaughan, R., Yasin, T., Powell-Chandler, A., Mcmillan, M. J. A., Ling, J. J., Pendelbury, L., Kerimzade, K., Howard, E. O., Humayun, S., Wadsworth, O. J., Roche, C. D., Andrew, K., Bhamra, N., Leong, S., Mistry, R., Noble, H., Rashed, F., Walker, N. R., Watson, L., Worsfold, M., Yarham, E., Wood, F., Arshad, A., Barmayehvar, B., Cato, L., Chan-lam, N., Do, V., Leong, A., Zheleniakova, T., Tan, K., Abdelhameed, F., Haglund, C., Radnaeva, I., Hu, N., Rambhatla, S., Waldron, D., Madahar, P., Malik, S., Coppel, J., Hussain, S. T., Mahmood, R., Nourzaie, R., Sheik-Ali, S., Thomas, A., Alagappan, A., Ashour, R., Bains, H., Diamond, J., Gordon, J., Ibrahim, B., Khalil, M., Mittapalli, D., Neo, Y. N., Patil, P., Peck, F. S., Reza, N., Swan, I., Whyte, M., Campbell, A., Meney, L. C., Kang, C. K., Chiu, J. Z. J., Livie, V., Livie, J., Chaudhry, S., Hernon, J., Khawar, H., O'Brien, J., Pullinger, M., Rothnie, K., Ujjal, S., Gorgievska, R. e. b. e. c. c. a., Pooley, G., Shishkin, B., Gorgievska, R., Docherty, J., Southgate, A., Coomes, A., Chaudhry, F. 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V., Radulovic, R., Milo??evic, K., Bojicic, J., Gencic, M., Jankovic, U., Jovanovic, M., El Kasmy El Kasmi, Y., G??mez Jurado, M. J., Alberti Delgado, P., Bordanova Reverter, A., G??mez del Pulgar, A., Belzunce-Cap??, J. F., Verdaguer Tremolosa, M., Lin, Q., P??rez-Ajates, S., Ramayo D??az, N., Gonz??lez Caraballo, I., Pascual Vicente, T., Orue-Echebarria, M. I., S??nchez-Calvo, L., Wang, D., Trueba-Collado, C., Morales Bernaldo de Quir??s, J. T., Anabitarte Bautista, O., Yebes, A., Espin-Basany, E., Clerc, D., Mignon, G., Vanoni, A., Henkens, A., Jarrar, G., Odovic, M., Willemin, M., Milliet, O., Hahnloser, D., Demartines, N., Curchod, P., Ciubotaru, C., Popescu, S., Popescu, S. S., Piras, K., Ciubotaru, C. I., Yanishev, A., Luzan, R., Lutovinova, E., Gavrilina, A., Barkovskaya, A., Kudelkina, N., Topchubaev, D., Ozkan, B. B., Yagiz Sen, A., Aktas, M. K., Aykun, N., Agca, M. H., Bilen, C., Kilinc, I., Atar, C., Kilic, V., Aktuna, C., Aba, M., Eray, I. C., Baki, B. E., Arslan, E., Alemdag, G., Ulusahin, M., Gul, E. B., Yildirim, R., Semiz, A., Bektur, G., Tomas, K., Bodur, S., Y??ksek, B., Serin, H., Erd??nmez, H., G??rsoy, F., Kara, H., nsal, U., zbek, M., Kasar, P. A., Ipor, A., etin, M. F., Khaw, R. A., Mills, E., Manley, L. R., Vutipongsatorn, K., Thakral, N., Adra, M., Khan, S. M., Badran, A., Ramjeeawon, A., Tan, H. L., Rye, D. S., Rajaraman, N., Norman, J. G., Solomou, G., Baker, D. M., Brandao, B. D., Stainer, B., Onafowokan, O. O., Gharooni, A., Dabab, N., Carlton-Carew, S., Kungwengwe, G., Gabriel, M., Sewart, E., Lawday, S, Pockney, P., Chrimes, A., Agarwal, A., Zhao, J., Jayalath, J. M. S. N., Liebenberg, P., Khor, S., Muddasani, T., Dawson, A., Taylor, N., Stevenson, C., Drane, A., Pahalawatta, U., Lai, L. T., Debiasio, A., Jung, M., Brumfitt, C. D., Beh, Y. Z., Dudi-Venkata, N. N., Lee, Y. D., Stewart, P., Thirugnanasundralingam, V., Muir, K., Ng, B., Mendis, D. M., Robb, P. M., Lee, H. J., Wyche, A. A. B., Davis, L. T., Luong, J. K., Jegathees, T., Coulter-Nile, S. M. C. J., Gosselink, M. P., Wang, Y. L., Maciaszek, M., Chrapko, P. S., White, S., Ivanov, V., Borisova, A., Kuncarov??, K., Ri??ko, J., Ludvik, M., Stercz, M., Treskon, R., Posp????il, M., Hlav??cov??, L., Tomanov??, D., Kolo??ov??, B., Sobotkov??, K., Cha, S., uta Kimle, K., Jirankova, K., Bujda, M., Pacl??k, A., Chrz, K., Antonova, T., Chodora, S., Houdek, O., Novick??, R., Skalick??, A., Farka??ov??, M., Jozaf, V., Klail, T., Prochazka, V., Harbjerg, J. L., Enevoldsen, M., H??jgaard Pedersen, J., Brandsborg, S., Amiri, S., Brinck, S., Jepsen, B. N., Hillgaard, T. K., Erichsen, S. B., Nielsen, C. V., Madsen, C. P., Bjerke, J., Skej??, C. D., Aabling, R. R., Kjaer, M. D., Unbehaun, K. P., Mark-Christensen, A., Dalsgaard, P., Trap, A., J??rgens-Lahnstein, J., Storm, M., Damgaard, I., Olawi, F., Ehlern, F., Raos, M., Ravn, S., Lycke, K. D., Kristensen, F. P., B??nnerup, K., Brigand, C., Dumange, E., Gout, M., Moehwald, C., Prem, M., Krupp, J., Alhalabi, O., Sliwinski, S., Gablenz, E., Seiboldt, T., Beck, L., Pohl, L. J., Zamzow, K., Betge, F., Poncelet, A., Truant, M., Hauschild, H., Neugebauer, N., D??rr-Harim, C., Schmitzer, L., Kopp, A., Steinle, J., Gsenger, J., Riccardi, M., Christodoulou, I. M., Zoikas, A., Machairas, N., Paspala, A., Papaconstantinou, D., Spartalis, E., Arkadopoulos, N., Prodromidou, A., Garoufalia, Z., Balalis, D., Manatakis, D. K., Kalles, V., Spyrou, I., Barkolias, C., Aguilera, M. L., Mendez, D., Rosales, J., Flores, M., Garcia, M., Garcia, A., Noriega, Z., Torselli, D., Rodriguez, J., Argenti, F., Milani, M. S., Malabarba, S., Giambartolomei, G., Vella, I., Gronchi, F., Ruggieri, A., Marano, L., Fleres, F., Lovisetto, F., Barberis, A., Serra, D., Sasia, D., Geretto, P., Pellegrino, L., Borghi, B., Marano, A., Corino, C., Cannata, G., Giuffrida, M. C., Landra, F., Giraudo, G., Segalini, E., Monti, M., Magnoli, M., Pata, G., Lucchi, A., Grassia, M., Cufari, M. E., Sagnotta, A., Di Cintio, A., Gemini, A., Trastulli, S., De Luca, M., Desiderio, J., Gubbiotti, F., Campagnaro, T., Pedrazzani, C., Turri, G., Lazzarini, E., Conti, C., Ruzzenente, A., Petrelli, F., Marziali, I., Mazzocato, S., Vergari, R., Piazzai, F., Kubolli, I., Aggiusti, A., Paolucci, A., Ortenzi, M., Gallo, G., Clerico, G., De Santi, G., Bitonti, M. F., Trompetto, M., Realis Luc, A., Papandrea, M., Cerra, C., Pirillo, M., Cravano, S., Libri, I., Laquatra, N., Isabello, A., De Luca, E., Testa, V., Morino, M., Mistrangelo, M., Sinibaldi, G., Angelucci, G. 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A., Tutino, R., Licari, L., Campanella, S., Profita, G., Falco, N., Rotolo, G., Venturelli, P., De Marco, P., Marcian??, M., Picciariello, A., Chetta, N., Aquilino, F., Papagni, V., Coletta, D., Cerasari, S., Galiffa, G., Lapolla, P., Del Basso, C., Cirillo, B., De Toma, G., Fazzi, K., Bini, S., De Padua, C., Savino, G., Finotti, E., Ferrara, F., Stella, M., Gobatti, D., Tamini, N., Brenna, R., Giani, A., Tirotta, F., Famularo, S., Angrisani, M., Ceresoli, M., Talamo, G., Sucameli, F., Gennai, A., Moggia, E., Bianchi, C., Bonfante, P., Macina, S., Feleppa, C., Imperatore, M., Berti, S., Parini, D., Lanari, J., Giamundo, P., lo Conte, A., Pagano, G., Manigrasso, M., Danzi, M., Amato, R., Anastasio, L., Mastella, F., Basile, R., Peltrini, R., Marra, E., Luglio, G., Giglio, M., Anoldo, P., Vertaldi, S., Grimaldi, L., Tammaro, N., Ripetti, V., D'Alessio, R., Benvenuto, D., Pesce, A., Menduni, N., Giudicissi, R., Zalla, T., Baraghini, M., Romoli, L., Calussi, M., Vellei, S., Genzano, C., Feroci, F., Vita, M., Giani, I., Goldin, E., Ciccioli, E., Galgano, A., Zuin, M., Bettella, A., Barina, A., Vendramin, E., Palano, G., Schiavone, D., Rega, D., La Manna, V., Migliore, G., Aversano, A., Fares Bucci, A., Belli, A., Andriola, V., Lafranceschina, S., Gordini, L., Erdas, E., Podda, F., Cappellacci, F., Salaris, C., Sanna, S., Marcialis, J., Longheu, A., Foppa, C., Coratti, F., Montanelli, P., Grandi, S., Nelli, T., Ben Khaled, N., Cammelli, F., Ferrini, E., Billo, M. E., Piccolo, G., Romano, S., Gaetano, P., Pilotta, F., Baldassarre, L., Birindelli, A., D'Errico, U., Bianchini, S., Ferrari, C., Franceschi, A., Caristo, G., Ballarini, Z., Romelli, M., Ruggiero, S., Percassi, A., Milone, M., De Rosa, M., Pipitone Federico, N. S., Molteni, B., Magri Piccinini, A., Tilocca, P. L., Marrosu, A. G., Scognamillo, F., Pala, C., Attene, F., Carboni, L., Ruggiu, M. W., Gabbas, G., Sancini, G., Roggiani, A., Balsamo, F., Gori, A., Cuicchi, D., Vittori, L., Piozzi, G. N., Tringali, D., Bevilacqua, E., Panizzo, V., Lauretta, A., Poillucci, G., Mulas, S., Simcikas, D., Samalavicius, N. E., Nutautiene, V., Zeromskas, P., Jurgaitis, J., Aliosin, O., Slepavicius, A., Eismontas, V., Kybransiene, M., Portelli, L., Cachia, C., Cefai, C., Youssef, Y., Degaetano, D., Debono, S., Sammut, M., Cassar, J., Sammut, K., Andrejevic, P., van Wijnbergen, J. W. M., Dinger, T. L., ten Doesschate, S. F. H., van Dalen, A. S. H. M., Looijen, R. C., Becker, M. A. J., Comert, D., Stellingwerf, M. E., Abdulrahman, N., van den Bos, D. D., Gr??ter, A., Vroom, Y., Voeten, D. M., Feenstra, T., de Roy van Zuidewijn, D., Hansmann, M., Nasimi, B., Gerdsen, M., Stijns, R. C. H., Leow, T. Y. S., Penningnieuwland, G., Davids, J., Medina Feliz, J., Kuiper, S. Z., Sluijpers, N. R. F., van de Pas, K. G. H., Pruijssers, S. R., Molenaar, C. J. L., Thomas, G., Farik, S., Chen, S. Y., Kilpatrick, K., Kim, D. H., Ong, H. I., Elliott, B. M., Geneta, V. P., Alsadat, R., Cherry, R., Chapman, D. A., Singh, N., Clucas, A., Gatenby, G., Kelly, B., Ruppeldt, P., Mcintosh, N. D., Li, Y., Wilton, S., Mclaughlin, S. J. P., Kearney, J., Sprosen, H., Kerckhoffs, P., Kandelaki, H., Welman, D., Coulter, J., Morreau, M., Li, E., Rankin, A., Winders, J., Skipworth, C., Peng, S. L., Campbell, S., Lim, Y. K., Yassaie, S. S., Dixon, S., Yassaie, S., Murray, M., Haran, C., Koh, S., Wilms, H., Dalzell, F., Tewhaiti-Smith, J., Kader, T., Yam, S. T., Dahya, D., Hardie Boys, M., Fleischl, W., Desmond, B., Tan, J., Skavysh, A., Castro, J., Orelhas, L., Santos, J., Pacheco, A., Rocha, A. F., Jervis, M. J., Pedro, V., Paix??o, V., Guerreiro, A., Melo, D., Laranjeira, A., Machado, A., Horta, V., Rocha-Melo, M., Patr??cio, J., Pereira, M., Lima, R., Cinza, A. M., Oliveira, J., Velez, C., Senhorinho, R., Catarino, S., Aveiro, D., Couto, M., Loureiro, A. R., Neves-Marques, C., Louro, T., Morgado, M., Ferreira, A. S., Alves, M., Oliveira, N., L??rias, R., Estalagem, I., Botelho, C., Alves-Vale, C., Correia, J. G., Jardim, J. A. M., Domingos, S. P., Bai??o, J. M., Rocha, B. S., Lopes, N. M. R. O., Jord??o, D. M., ngelo, M. D., Caro??o, T., Vieira, B. N., Silva, A. G., Galv??o, D., Mora, A., Bettencourt, R., Quintela, A. C., Alves, D., Dias, B., Costa, C., Gon??alves, J. P., Valente, P., Freire, L., Saraiva, R., Moreira, M., Peixoto, R., Serra, M. L., Santos, T. C., Lages, R. R., Pimentel, A., Martins, M., Maciel, J., B??rtolo, J., Fidalgo Antunes, C., Cabral, F., Brito Silva, F., Dias Matos, A., Santos, M., Cunha, R., Duarte, M., Sousa, M., Cunha, M., Neves, J., M??nica, I., Oliveira, S., Ribeiro, H., Ferreira, M., Guimar??es, N., Azevedo, J., Louro, H., Queiros, T., Castro, B., Fonseca, S., Carvalho, L., Torre, A. P., Amado, A., Leite, M., Romano, M., Gomes, J. R., Monteiro, R. G., Eir??, F., Borges, F., Sim??es, J., Botelho, P., Cismasiu, B., Romano, J., Monteiro, C., Silva, M., Claro, M., Almeida, P., Cruz, A., Vaz Pinto, G., Sousa, D., Costa Santos, D., Silva, A., Silva, F., Almeida, M. R., Parreira, R., Faustino, A., Medeiros, N., Castro, R., Soares, B., Resendes, M., Peyroteo, M., Canotilho, R., Correia, A. M., Martins, P. C., Machado, N. D., S??, T. C., Bernardes, F. M., Saraiva, P., Almeida, J., Mendes, M., Fernandes, V., Ribeiro, A., Soares, D., Capote, H., Fialho, G., Reia, M., Pratas, N., Costa, J., Morais, S., Miranda, P., Cunha, C., Sousa, X., Amado, F., Batista, A., Seabra, J., Praxedes, V., Monteiro, N., Martins, I., Lamas, M., Devesa, H., Miranda, J., Martins, S. F., Cavadas, D., Silva, R., Pina, S., Paix??o, I., Frade, S., Guerreiro, I., Tom??, M., Patrocinio, S., Costa, M., Rosete, M., Senaratne, R., Kakodkar, P., Balasubramanian, I., Hogan, A., Al-Salihi, A., Vyas, V., Vedadi, A., English, C., Mohammed, N., Dervan, L., Kang, S. J., Morrissey, E., Compton, M., Litvin, A., Romanova, E., Ponomarev, N., Savchenko, A., M??sz??rosov??, K., Zubowicz, M., Such??n, P. K., Gerstmeier, J., Brazitikou, E., Fytrou, E., Celik, M., Dubovsk??, M., Schmalenbeck, J., Sautter, S. C., Ceyran, H., Panyko, A., Jaich, R., Fitchat, N., De Lima, H., Withey, K., Piperidis, A., Toyi, Y., Nicolaides, A., Brooks, S., Jaffer, T., Sparke, A., Van Staden, N., Mcduling, C. R., Claassen, L., Van Vuuren, S., Marx, M., Kruger, C., Weyers, J., Lecler, J., Nshalati Salvation, M., Mathebula, S., Chauke, J., Mculu, W., Ngwenya, Z., Cardo, J. Garc??a., Mora-Guzm??n, I., Sancho Muriel, J., de Andres Olabarria, U., Casaval Cornejo, L., Vicente Rodr??guez, I., Jim??nez Escovar, F., Calvo Fern??ndez, M., Portugal Mart??nez, A., Badiola Bergara, I., Landaluce Olavarria, A., del Pozo Andr??s, E., Muriel, P., Mestres, N., Cuello, E., Merichal, M., Sierra, J. E., Escoll, J., Rufas, M., Pinillos, A. I., Ortega, J., Cerd??n, C., Jimenez Vi??as, C., Alconchel, F., Mart??nez D??az, J. M., Ruiz Manzanera, J. J., Navarro Barrios, ??., Rodr??guez Pedre??o, L., Moreno, P. Garc??a., G??mez, M. Garc??a., Rodrigues, K., Abrisqueta, J., Esteban Sinovas, O., Oro, C. Fair??n., L??pez Otero, M., Toimil, C. Samart??n., Primo ??lvarez, J. C., Rodriguez Fernandez, L., Paniagua Garcia Se??orans, M., Figueroa Jim??nez, S., Livianos Arias-Camis??n, P., Nieto Arranz, J. M., Mateos Sexmero, M. J., Diego Alonso, E., Gonz??lez Amor, L., Claramonte Bellmunt, O., Mart??nez Caballero, J., Rubio-P??rez, I., Ramos Martin, P., Mate Mate, P., Marcano Chavez, C., Rubio-Perez, I., Ayllon, H., Aguilar-Mart??nez, M. M., Arroyo, A., Segura-Sampedro, J. J., Jer??-McFarlane, S., Soldevila-Verdeguer, C., Pine??o-Flores, C., Ambrona-Zafra, D., Fern??ndez-Vega, L., Gil-Catal??n, A., Craus-Miguel, A., Pujol-Cano, N., Sena-Ruiz, F., Olmedo Moreno, C., Pastor Idoate, C., Negre Parra, D., Soriano Li??bana, M. M., Campo Betancourth, C. F., Sevila Mico, S., Est??vez Diz, A. M., Mart??n-Balbuena, R., Garc??a-Vico, A., Roman-Rando, A., S??nchez-G??lvez, M. ??., Bersabe-Alonso, I. M., Vadillo-Bohorquez, A., Bustamante Recuenco, C., Calzada, M. G., Recuenco, C. B., Martin, M. C., Licardie Bola??os, R. E., Garcia Orozco, J. J., Ferrusola Diaz, D. A., Garcia Jimenez, M. L., Castro Diez, L., Mosquera Fernandez, C., Fern??ndez, P., Platero Diago, J., Veras Lista, M., Rif?? Terricabras, S., Butler Sanz, L., Alberch Camprub??, E., Rico Ferr??ndez, M., Puig Lao, E., De Pablo Mir??, M., D??az Padillo, A., Padilla Zegarra, E. D., Franco, M., Martinez, A., Forero-Torres, A., Alonso-Poza, A., Dieguez, B., Losada, M., Gilsanz, C., Alberdi San Rom??n, I., Ramos Jim??nez, F. A., P??rez Ortega, A., Trujillo Barbadillo, A., Romero Pujana, E., Fernandez Illera, M. V., Salvador Ros??s, H., Delisau Puig, O., Castro, A., Codony Bassols, C., Fernandes, N., damez, J. Garc??a., Caula Freixa, C., G??mez Romeu, N., Merayo ??lvarez, M., Merayo Alvarez, M., Alonso Batanero, E., Canales, I. Cifri??n., Villarejo Campos, P., Alberca-Paramo, A., Alia Verdejo, T., Ca??ete-Manzanares, J., Molina-Florez, M., Hern??ndez, L. C. Garc??a., Orozco Nu??ez, S., Suarez-Sanchez, M., Martin-Fernandez, J., Estaire Gomez, M., Lopes Moreira, C. C., Gutierrez Rios, R. D., Eizaguirre Ubegun, M., Novo Sukia, I., Uribe Isado, M., Iba??ez Alda, M., Enriquez-Navascues, J. M., Uriol Peralta, P., Lima Pinto, F., N????ez O??Sullivan, S., Serrano Navidad, M., Vivas Angeles, P., Vives Figueras, R., Baena Sanfeliu, E., Campillo Alonso, B., Alberich Prats, M., Duran Arrocha, J., Cornell?? Garceso, N., Uribe Galeano, C., Collado-Roura, F., Ripoll??s-Melchor, J., Garcea, A., G??mez Facundo, H., Troncoso Pereira, P., Garcia, J. M., Gil, A., Giordano, H. E., P??rez Guarinos, C. V., Blaser, B., Imadalou, L., Piazza, G., Teixeira, H., Pittet, O., Gaspar, S., Gagliardi, B., Haller, M. L., Huot, A., Yurdaor, S. S., Alim, Y. E., Binbuga, M., K??rkl??, ??., Ceylan, C., Yilmaz, S., alar, S. N., Yildirim, N., Yavuz, G., Biyiklioglu, O., Kopac, O., Baykan, B., Abbasguliyev, H., Mutlu, V., Mahmoudi, Y., Dossa, S. A. A., Mizan, S. R., Demirtas, B., Cavus, T., Yuksek, A., Karabulut, K., Uyanik, A., Kargici, K., Banaz, T., Abdulrahman, S. M. F., Yesilsancak, M., Yanikoglu, E., Karabulut, A., Kuyumcu, O. F., Kutluk, F., Tunc, E., Ozmen, B. B., Kurtoglu, G. K., Sel, E. K., Isler, V. C., Yilmaz, B. S., Adiyaman, C., Kara, M., Demirkaya, H. C., Korkmaz, H. K., Pektas, A. M., Mutlu, D., Tiftik, E., Aksoy, A. B., Karag??z, E., Sabanci, R., T??mer, S. S., Sarig??l, L., Aksoy, B., Emiroglu, B., Mollavelioglu, B., Gereklioglu, D., Guler, M., Toprak, S., Afsar, H. B., Guler, S. E., Alizade, E., Aydin, T., Yalcinkaya, A., Erdem, M., Kayacan, S., Sahin, C., Uysal, M., Karakus, K., Altiner, S., Demirci, Z. S., Eren, E., Yavas, M., Dogan, H., Ozoglu, F., Mazlum, S. S., Yelkenci, C., Baran, T., Satilmisoglu, M., Sahin, A. Z., Kilin??, A., Isik, K., Kocer, M. D., G??ner, B., Islek, E. C., Tombul, H. B., Boztug, C. Y., Tinaz, A., Yilmaz, M., Karaman, Y., Akin, F. A., Dansuk, S., Bas??avus, M., Kaya, M., Kutlu, B., Akyol, C., Bilicen, G., Yarenci, E., Demiroglu, Y., Sunal, A., Cinar, E. N., Tipi, O. U., Benli, G. E., Tasdelen, I., Tura, A., Ucar, A., Ekci, B., Bilgili, A. C., Kiraz, I. N., Aksoy, H., Basak, A., Karip, B., Uslu, ??., Seker, M. C., Erten, V., Memis, U., Ko??ak, Z. B., Karapinar, Y. E., Fakirullahoglu, M., K??seoglu, E., Yeni, M., Uygur, F. A., Kaya, Y., zen, D., lmez, M., Altintas, E., Toklu, R., Sari??i??ek, T., Isik, A. E., Demirci, K., Suresh, G., Anbarasan, J., Rehman, S., Hu, E., Timms, S., Reynolds, W., Hotchkies, A., Misra, V., Finch, B. J., Philip Rajathasan, T., Jeddy, H., Kyaw, H. A., Wong, N., Bhahirathan, Y., Donaldson, C., Sequeira Campos, M., Armitage, M. N., Hussain, A. S., Hardy, B., Hassan Serry, M. Y., Herron, J., Thakrar, C., Rojoa, D., Yeap, B., Iqbal, Z., Rojoa, D. M., Cabaleiro Barciela, C., Ruddy, C. M., Lindwe, S., Qamar, Y., Chuita, S., James, A., Bugelli, M., Chechelnitskaya, Y., Bylinski, T., Findlay, J. M., Skan, O., Kind, C., Tupper, P., Van Rhee, C., Honeyman, S. I., Menon, G., Sloper, W., Burford, C., Coey, J., Akbari, K., Whitehead, T., Dimitriadis, S., Marshall, K., Flint, E. J., Can, B., Cesmeli, E., Kus, D., Kavar, R. C., Cevlik, A. D., Cengiz, U., Turk, E. G., Yilmaz, I., Yumurtaci, ??., Emin, A., Girit, ??. a. g. r. i., Yildirak, M. K., Senyigit, E., G??ldag, A., S??yleyici, B., Aytin, Y. E., Akay, F. E., Iskan, N. G., Mutlu, B., Sunay, A. O., Bell, T., Limnatitou, D., Gormley, S., Taleongpong, P., Patel, V., Macgregor, L., Amini, S., Turner, C., To, N., Laurence, N., Green, C., Frostick, R., Khera, R., Povey, M., Mahapatra, S., Bradbury, M., Osunronbi, T., Tam, L. Y. C., Khanan Kaabneh, A., Lawther, J., Fisher, P., Tribedi, T., Moosa, A., Ramdin, A., Mcgee, F., Flanagan, S., Tan, Q. J., Anwar, H., Clough, R., Chrisp, B., Cassels, J., Cross, G. W. V., Refalo, A., Hadley, R., Mctighe, A., Farrow, F., Brodie, A., Davis, G., Shah, D. R., Bowers, C., M. P. E., Ng, Wong, R. T. W., Maese, S., Tandon, R., Gray, M., Kumar, A., Ciurleo, C., Nyamali, I., Hiremath, S., Sinha, S., Chowdhary, M., Kirupananthan, P., Boh, Z. Y., Dass, S., Soma, A., Newton, A., Hill, M., Shafiq, Y., Brkljac, M., Martin, H., Mcclarty, C., Sanyal, S., Alsaif, A., Bhopal, S., Muneeb, F., Page, O., Zeb, E., Al-Azzawi, A., Mcintosh, J., Vucicevic, A., Hughes, M., Brooks, L., Fanibi, B., Dixon, M., Njoku, P., Morris, D., Jobson, J., Trussell, S., Chowdhury, H., Alawode, D. O. T., Udayachandran, V., Alsoof, D., Ekert, J., Joseph, N., Zulkefley, N., Hunt, G., Christodoulou, T., Wright, O., Soman, S., Jamal, M., Beqiri, S., Borgas, P., Pereira, F., Browne, S., Yiu, J., Dworkin, A., Mak, J., Patrawala, S., Milinkovic, N., Schofield, R., Chauhan, M., Hartley, L., Hind, J., Heybourne, A., Morgan, H., Wickstone, C., Panagiotou, D., O'Connell, E., Dean, K., Iqbal, R., Walsh, L., Yu, N., Rana, N., Massie, E., Foong, J., Lee, Y. J., Mijalkov, D., Wells, A., Bull, N., Ajmera, A., Warburton, T., Morgan, S., Mahmoud, A., Schachtel, M., Mikhail, B., Fomin, I., Mekaeil, B., Jun, H. J. S., Hengpoonthana, R., Childs, S., Ridgway, S., Blefari, N. D. A., Tam, H., Puchalski, N., Ngai, C., Mackenzie, J., Johnson, N., Holmes, M., Zuzek, R., Saluja, T., Gould, T., Goh, Y. K., Selvaraj, T., Horne, D., Borrow, J. L., Campbell, C., Cousins, G., Jackson, L., Maheepala, K., Zhao, S., Holden, E., Tutt, L., Thompson, B., Collins, H., Louie, F., Buckland, B., Smith, D., Chong, C., Chua, T. H., Nayak, C., Redmond, J., Tan, R. R., Gramlick, M., Teh, J. S., S. Y., Ng, Britten-Jones, P., Mohd Rosli, R., Pham, H. D. V., Harris, M., Salibasic, M., Pavlov, V., Paycheva, T., Lyulenina, E., Kolev, N., Boev, B., Nguen, D., Mitkov, Y., Mitkov, E., Vladova, P., Dimitrov, V., Gabarski, A., Feradova, H., Mladenov, T., P??s, M., Adel, A., Sotona, O., Barto??, M., Amjad, T., Mal??, O., Berec, S., Hanu??ov??, M., Hurn??, M., rhalmi, J., S??rensen, J. S., Chanut, F., Magnin, J., Sch??ning, L., CS Simon, S., Galata, C., Karampinis, I., Th??wel, T., Seckler, A. M., Kerem, C., Durdevic, S., Herrle, F., Artioli, E., Giaccari, S., Nevoso, V., Schimera, A., Marino, S., Resta, G., Ongaro, D., Baronio, G., Raimondo, S., Casiraghi, S., Salvadori, R., Armellini, A., Vulcano, I., Bertilone, E., Pintabona, G., Viscosi, F., Mazzeo, C., Olivieri, M., Belluco, C., Antona, A. D., Basso, S., Frattalone, M., Marino, F., Carbone, F., Incollingo, P., Romano, F. M., Anania, M., Pulighe, F., Cruccu, A., Murru, M. L., Massaiu, C., Balestra, F., Pazzona, M., De Nisco, C., Gusai, G. P., Giannella, A., Santangelo, M., Frangella, F., Magagnano, D., Liberatore, P., Rondelli, F., Castagnoli, G., Bartoli, A., Bellochi, R., Spaziani, A., Conti, D., Poponesi, V., Trippetti, M., Amicucci, S., Tazza, G., Procacci, P., Giovannini, F., Basile, E., Moschetta, G., Cosmi, F., Romeo, G., Gasparrini, M., Virgilio, E., Sparta, C., Mura, F. A., Barmina, M., Lorettu, A., Rettaroli, C., Mastino, G., Ruggiu, G. V., Mura, G. A., Perrone, B. A., De Angelis, M., Mereu, A., Adamo, V., Bianco, C., Ricciardiello, M., Campanaro, C., Panaccio, P., Esposito, L. M., Di Mola, F. F., D'Ascanio, F., Pietroletti, R., Di Marco, F., Amico, A., Schembari, E., Puglisi, S., Tuminello, F., Fig??, F., Caiazzo, A., Selvaggi, L., Capozzolo, A., Braccio, B., Tru??kovs, A., Bartnick, A., Malcevs, E., Machatschek, M. J., Alm, J., Lapsa, S., Delorme, M., Zeynalov, F., Larnovskis, J., Sauka, J., Bodrov, D., Gailumsis, R., Wiemann, A. M., M??ller, N. L., Jelovskis, I., Deksnis, D., Bauermeister Potts, O., Slimbajevs, T., Ancans, G., Dulskas, A., Kuliavas, J., Kavaliauskas, P., Kavaliauskaite, R., te Molder, L., Tromp, J., Matthee, E., Tissen, Y. M., Brinkhuis, E., de Vries, H. S., Hart, E. 't., Beckers, K., Bekker, Y., Kakar, S., van Smaalen, T. C., Veen, O. C., Dingemans, S. A., van den Brink, L. C., Vijgen, G. H. E. J., van de Voort, E. M. F., van der Pool, A., van Rest, K. L. C., Haak, T., Gordinou de Gouberville, M. C., Saleh, S., Mens, M. A., Hoeks, E. M., Nieuwenhuizen, S., Brandsma, A. M., van Praag, E. M., Westerduin, E., Smit, M. P. C. M., van der Lely, S. J., de Ruiter, A., Ribbers, T., Aarts, C. A. M., Tulek, M. S., de Jonge, J., Kocak, S., Alqethami, H. J., Constansia, R., van Elst, P. C., Tissink, M. W., Azzahhafi, J., Bofarid, S., Kip, M., Saleh, W., Franssen, S., Boon, C. L., Franssen, R. J. M., Romaen, I., Jense, M. T. F., D'Souza, J., Pascoe, R., Scott, A., Stark, E., Mulholland, K., Lau, W. K., Smith, B., Adams, S. I. B., Shah, N., Ling, E., Young, J., Hawkins, R., Jacobson, A., Macfater, H., Stanfield, B., Henderson, N., Chuang, A., Maskill, L., Ker, H., Mouldey, K., Hu, R., Matthews, C., Aitken, E., Walker, M., Winstanley, J., Miguel, I., Martins, J., Cunha, M. F., Melo, J., Veiga, D. N., Rachadell, J., Amorim, E., Vareda, R., Roseira, J., Americano, M., Correia, D., Capella, V., Moinhos, T., Costa, F., Gil, I., Morgado, J., Varghese, S., Boyle, E., Aljohmani, L., Alexander, J., Graziadei, V., Mccaughey, C., Jain, A., O'Connor, D. B., Ramanayake, H., Sabnani, R., Colon, L. F., Bansal, N., Stephens, I., Tan, R., Hoo, M., Doherty, G., Fenn, S., Mulhare, E., Walsh, M., Leavey, C., Costigan, O., Griffin, S., Dockry, ??., Khogali, E., Aly, A. K., Mcphedran, R., O'Gorman, D., Vermeulen, D., Gopaul, A., Pentony, A. R., Piong, C. L., Nossier, R., Hanna, J., Sabir, K., Eow, S. Y., Ladak, N., Boersma, D., Kamath, P. J., Soh, T. B. W., Dyer, A. H., Chee, S. Y., Tan, I. X. H., Kelliher, A., Scanlon, K., Adeusi, L., Howarth, N., Mccawley, N., O'Neill, A., Jones, M. R., Saleh, R., Singh, A., O'Dwyer, N., Mana, O. C., Gomez, H., Riba, L., Perez, J., Centeno, A., Ortega, C., Ossola, M. E., Camarero, E., Mart??nez Ill??n, M., Aranda Garc??a, L., L??zaro Cardona, M., Montalvo Olmedo, C., Izquierdo Moreno, A., Cuenca Ram??rez, A., Margarida, A., Pando, B., Liquete Mar??n, L., P??rez Calle, M., Ramos Cordero, M. J., Sagredo Cuartango, A., S??nchez, E., Marcos Rodrigo, A., Fernandez, A., Curtis, C., Bosch, M., Triguero, D., Bosch Ram??rez, M., De La Llave Serralvo, A., S??nchez, M. J., Mart??n-Borreg??n, P., Quevedo, A., Mart??nez, J., Mar??n, J. M., Rodr??guez, P., Esteban Avenda??o, I., Jim??nez Relimpio, C., Lancho Lavilla, P., Blanco Bartolom??, I., G??mez Cano, I., Blasco Andr??s, C., Abad-Motos, A., Mar??nez-Hurtado, E., Salvachua-Fern??ndez, R., Muniesa, C., Avelino, L., Cholewa, H., Sancho-Muriel, J., Navasquillo, M., Nav??o, A., Abell??, D., De Jesus, M., Alvarez, E., Kefleyesus, A., Bugmann, A., Piotet, L. M., Meijers, L., Tonchev, P., Tamosiunas, A., Rottier, S. J., Negoi, I., Bernado, I. R., Eftychiou, S., Psychiatry, Surgery, RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tampere University, Kanta-Häme Central Hospital Hämeenlinna, Ahmed, W, Bhatia, S, Mclean, K, Khaw, R, Baker, D, Kamarajah, S, Bell, S, Nepogodiev, D, Harrison, E, Glasbey, J, Borakati, A, Burke, J, Drake, T, Bath, M, Claireaux, H, Gundogan, B, Mohan, M, Deekonda, P, Kong, C, Joyce, H, Mcnamee, L, Woin, E, Khatri, C, Fitzgerald, J, Bhangu, A, Arulkumaran, N, Duthie, F, Hughes, J, Pinkney, T, Prowle, J, Richards, T, Thomas, M, Blanco-Colino, R, Chapman, S, Pata, F, Pellino, G, Sgro, A, van Elst, T, Van Straten, S, Knowles, C, Dynes, K, Patel, M, Patel, P, Wigley, C, Suresh, R, Shaw, A, Klimach, S, Jull, P, Evans, D, Preece, R, Ibrahim, I, Manikavasagar, V, Smith, R, Brown, F, Teo, R, Sim, D, Logan, A, Barai, I, Amin, H, Suresh, S, Sethi, R, Gul, W, Bolton, W, Corbridge, O, Horne, L, Attalla, M, Morley, R, Robinson, C, Hoskins, T, Mcallister, R, Lee, S, Dennis, Y, Nixon, G, Heywood, E, Wilson, H, Ng, L, Samaraweera, S, Mills, A, Doherty, C, Belchos, J, Phan, V, Lim, M, Miller, F, Chouari, T, Gardner, T, Goergen, N, Hayes, J, Macleod, C, Mccormack, R, Mckinley, A, Mckinstry, S, Milligan, W, Ooi, L, Rafiq, N, Sammut, T, Sinclair, E, Smith, M, Wong, J, Ablett, A, Tie-Gill, T, Ramsay, G, De Paola, L, Mcguckin, S, Alshakhs, A, Ahmeidat, A, Francis, A, Baker, C, Boulton, A, Collins, J, Copley, H, Fearnhead, N, Fox, H, Mah, T, Mckenna, J, Naruka, V, Nigam, N, Nourallah, B, Perera, S, Qureshi, A, Saggar, S, Sun, L, Wang, X, Yang, D, Ali, Z, Mullarkey, L, Walshe, R, Lewis, E, Berry, B, Moneim, J, Mookerjee, S, Al-Hadithi, A, Caroll, P, Doyle, C, Elangovan, S, Falamarzi, A, Gascon Perai, K, Greenan, E, Jain, D, Lang-Orsini, M, Lim, S, O'Byrne, L, Ridgway, P, Van der Laan, S, Arthur, J, Barclay, J, Bradley, P, Edwin, C, Finch, E, Hayashi, E, Hopkins, M, Kelly, D, Kelly, M, Mccartan, N, Ormrod, A, Pakenham, A, Christy, S, Hayward, J, Hitchen, C, Kishore, A, Martins, T, Philomen, J, Rao, R, Rickards, C, Burns, N, Copeland, M, Durand, C, Dyal, A, Ghaffar, A, Gidwani, A, Grant, M, Gribbon, C, Gruhn, A, Leer, M, Ojofeitimi, O, Carroll, L, Hylands, A, Delaugere, L, Reveendran, D, Ahmad, K, Beattie, G, Beatty, M, Campbell, G, Donaldson, G, Graham, S, Holmes, D, Kanabar, S, Liu, H, Mccann, C, Stewart, R, Vara, S, Coulter, C, Ralston, C, Laverty, L, Gallagher, P, Ajibola-Taylor, O, Andah, E, Ani, C, Cabdi, N, Ito, G, Jones, M, Komoriyama, A, Titu, L, Ahmed, A, Yeo, Y, Elliott, D, Bennett, J, Mcnamara, M, Sivarajah, S, Dunmore, C, Basra, M, Gallogly, P, Harinath, G, Leong, S, Pradhan, A, Siddiqui, I, Zaat, S, Ali, A, Galea, M, Looi, W, Ng, J, Farhan-Alanie, M, Aitken, G, Nair, M, Aly, M, Buari, M, Atkin, G, Azizi, A, Cargill, Z, China, Z, Elliot, J, Jebakumar, R, Lam, J, Mudalige, G, Onyerindu, C, Renju, M, Shankar Babu, V, Ahmed, K, Sheikh, Z, Monks, M, Lehmann, J, Rotimi, O, Hussain, M, Joji, N, Lovett, B, Mownah, H, Dwyer-Hemmings, L, Busuttil, A, Powell, J, Hensher, C, 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E., Piccolo, G., Romano, S., Gaetano, P., Pilotta, F., Baldassarre, L., Birindelli, A., D'Errico, U., Bianchini, S., Ferrari, C., Franceschi, A., Caristo, G., Ballarini, Z., Romelli, M., Ruggiero, S., Percassi, A., Milone, M., De Rosa, M., Pipitone Federico, N. S., Molteni, B., Magri Piccinini, A., Tilocca, P. L., Marrosu, A. G., Scognamillo, F., Pala, C., Attene, F., Carboni, L., Ruggiu, M. W., Gabbas, G., Sancini, G., Roggiani, A., Balsamo, F., Gori, A., Cuicchi, D., Vittori, L., Piozzi, G. N., Tringali, D., Bevilacqua, E., Panizzo, V., Lauretta, A., Poillucci, G., Mulas, S., Simcikas, D., Samalavicius, N. E., Nutautiene, V., Zeromskas, P., Jurgaitis, J., Aliosin, O., Slepavicius, A., Eismontas, V., Kybransiene, M., Portelli, L., Cachia, C., Cefai, C., Youssef, Y., Degaetano, D., Debono, S., Sammut, M., Cassar, J., Sammut, K., Andrejevic, P., van Wijnbergen, J. W. M., Dinger, T. L., ten Doesschate, S. F. H., van Dalen, A. S. H. M., Looijen, R. C., Becker, M. A. J., Comert, D., Stellingwerf, M. E., Abdulrahman, N., van den Bos, D. D., Grüter, A., Vroom, Y., Voeten, D. M., Feenstra, T., de Roy van Zuidewijn, D., Hansmann, M., Nasimi, B., Gerdsen, M., Stijns, R. C. H., Leow, T. Y. S., Penningnieuwland, G., Davids, J., Medina Feliz, J., Kuiper, S. Z., Sluijpers, N. R. F., van de Pas, K. G. H., Pruijssers, S. R., Molenaar, C. J. L., Thomas, G., Farik, S., Chen, S. Y., Kilpatrick, K., Kim, D. H., Ong, H. I., Elliott, B. M., Geneta, V. P., Alsadat, R., Cherry, R., Chapman, D. A., Singh, N., Clucas, A., Gatenby, G., Kelly, B., Ruppeldt, P., Mcintosh, N. D., Li, Y., Wilton, S., Mclaughlin, S. J. P., Kearney, J., Sprosen, H., Kerckhoffs, P., Kandelaki, H., Welman, D., Coulter, J., Morreau, M., Li, E., Rankin, A., Winders, J., Skipworth, C., Peng, S. L., Campbell, S., Lim, Y. K., Yassaie, S. S., Dixon, S., Yassaie, S., Murray, M., Haran, C., Koh, S., Wilms, H., Dalzell, F., Tewhaiti-Smith, J., Kader, T., Yam, S. 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S., Chanut, F., Magnin, J., Schöning, L., CS Simon, S., Galata, C., Karampinis, I., Thäwel, T., Seckler, A. M., Kerem, C., Durdevic, S., Herrle, F., Artioli, E., Giaccari, S., Nevoso, V., Schimera, A., Marino, S., Resta, G., Ongaro, D., Baronio, G., Raimondo, S., Casiraghi, S., Salvadori, R., Armellini, A., Vulcano, I., Bertilone, E., Pintabona, G., Viscosi, F., Mazzeo, C., Olivieri, M., Belluco, C., Antona, A. D., Basso, S., Frattalone, M., Marino, F., Carbone, F., Incollingo, P., Romano, F. M., Anania, M., Pulighe, F., Cruccu, A., Murru, M. L., Massaiu, C., Balestra, F., Pazzona, M., De Nisco, C., Gusai, G. P., Giannella, A., Santangelo, M., Frangella, F., Magagnano, D., Liberatore, P., Rondelli, F., Castagnoli, G., Bartoli, A., Bellochi, R., Spaziani, A., Conti, D., Poponesi, V., Trippetti, M., Amicucci, S., Tazza, G., Procacci, P., Giovannini, F., Basile, E., Moschetta, G., Cosmi, F., Romeo, G., Gasparrini, M., Virgilio, E., Sparta, C., Mura, F. 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E., Camarero, E., Martínez Illán, M., Aranda García, L., Lázaro Cardona, M., Montalvo Olmedo, C., Izquierdo Moreno, A., Cuenca Ramírez, A., Margarida, A., Pando, B., Liquete Marín, L., Pérez Calle, M., Ramos Cordero, M. J., Sagredo Cuartango, A., Sánchez, E., Marcos Rodrigo, A., Fernandez, A., Curtis, C., Bosch, M., Triguero, D., Bosch Ramírez, M., De La Llave Serralvo, A., Sánchez, M. J., Martín-Borregón, P., Quevedo, A., Martínez, J., Marín, J. M., Rodríguez, P., Esteban Avendaño, I., Jiménez Relimpio, C., Lancho Lavilla, P., Blanco Bartolomé, I., Gómez Cano, I., Blasco Andrés, C., Abad-Motos, A., Marínez-Hurtado, E., Salvachua-Fernández, R., Muniesa, C., Avelino, L., Cholewa, H., Sancho-Muriel, J., Navasquillo, M., Navío, A., Abelló, D., De Jesus, M., Alvarez, E., Kefleyesus, A., Bugmann, A., Piotet, L. M., Meijers, L., Tonchev, P., Tamosiunas, A., Rottier, S. J., Negoi, I., Bernado, I. R., Eftychiou, S., RS: NUTRIM - R2 - Liver and digestive health, MUMC+: MA Mondzorg Kaak Aangezicht Chirurgie (9), Kindergeneeskunde, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, and Faculteit Medische Wetenschappen/UMCG more...
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renal failure ,cohort studies ,humans ,kidney ,postoperative complications ,prognosis ,prospective studies ,retrospective studies ,risk assessment ,risk factors ,acute kidney injury ,digestive system surgical procedures ,Prognosi ,Acute Kidney Injury/diagnosis ,Digestive System Surgical Procedures/adverse effects ,3121 Internal medicine ,Kidney ,Risk Assessment ,Cohort Studies ,Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] ,All institutes and research themes of the Radboud University Medical Center ,Postoperative Complications ,Retrospective Studie ,Risk Factors ,Gastrointestinal Surgery ,Humans ,preoperative care ,Prognostic Model ,Prospective Studies ,Digestive System Surgical Procedures ,Retrospective Studies ,Science & Technology ,Risk Factor ,MORTALITY ,General Medicine ,STARSurg Collaborative and EuroSurg Collaborative ,Acute Kidney Injury ,Prognosis ,surgical procedures ,Prospective Studie ,aki ,OAKS ,Postoperative Complications/etiology ,colorectal surgery ,Surgery ,Postoperative Complication ,Cohort Studie ,Life Sciences & Biomedicine ,Human - Abstract
Background Postoperative acute kidney injury (AKI) is a common complication of major gastrointestinal surgery with an impact on short- and long-term survival. No validated system for risk stratification exists for this patient group. This study aimed to validate externally a prognostic model for AKI after major gastrointestinal surgery in two multicentre cohort studies. Methods The Outcomes After Kidney injury in Surgery (OAKS) prognostic model was developed to predict risk of AKI in the 7 days after surgery using six routine datapoints (age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker). Validation was performed within two independent cohorts: a prospective multicentre, international study (‘IMAGINE’) of patients undergoing elective colorectal surgery (2018); and a retrospective regional cohort study (‘Tayside’) in major abdominal surgery (2011–2015). Multivariable logistic regression was used to predict risk of AKI, with multiple imputation used to account for data missing at random. Prognostic accuracy was assessed for patients at high risk (greater than 20 per cent) of postoperative AKI. Results In the validation cohorts, 12.9 per cent of patients (661 of 5106) in IMAGINE and 14.7 per cent (106 of 719 patients) in Tayside developed 7-day postoperative AKI. Using the OAKS model, 558 patients (9.6 per cent) were classified as high risk. Less than 10 per cent of patients classified as low-risk developed AKI in either cohort (negative predictive value greater than 0.9). Upon external validation, the OAKS model retained an area under the receiver operating characteristic (AUC) curve of range 0.655–0.681 (Tayside 95 per cent c.i. 0.596 to 0.714; IMAGINE 95 per cent c.i. 0.659 to 0.703), sensitivity values range 0.323–0.352 (IMAGINE 95 per cent c.i. 0.281 to 0.368; Tayside 95 per cent c.i. 0.253 to 0.461), and specificity range 0.881–0.890 (Tayside 95 per cent c.i. 0.853 to 0.905; IMAGINE 95 per cent c.i. 0.881 to 0.899). Conclusion The OAKS prognostic model can identify patients who are not at high risk of postoperative AKI after gastrointestinal surgery with high specificity. Presented to Association of Surgeons in Training (ASiT) International Conference 2018 (Edinburgh, UK), European Society of Coloproctology (ESCP) International Conference 2018 (Nice, France), SARS (Society of Academic and Research Surgery) 2020 (Virtual, UK). more...
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- 2022
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10. Défis et opportunités d’intégration des soins palliatifs : perspectives des patients et proches aidants dans les maladies respiratoires chroniques avancées
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Baptista Peixoto Befecadu, F.A., James, R., Pautex, S., Bergeron, A., Guerreiro, I., and Hentsch, L.
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- 2025
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11. Posttraumatic Stress Disorder and Hyperventilation in Post-COVID-19 Syndrome: An Underestimated Association
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Benzakour, L., primary, Voruz, P., additional, Lador, F., additional, Guerreiro, I., additional, Kharat, A., additional, Assal, F., additional, and Péron, J.A., additional
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- 2022
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12. Black soldier fly meal effects on meagre health condition: gut morphology, gut microbiota and humoral immune response
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Couto, A., primary, Serra, C.R., additional, Guerreiro, I., additional, Coutinho, F., additional, Castro, C., additional, Rangel, F., additional, Lavrador, A.S., additional, Monteiro, M., additional, Santos, R., additional, Peres, H., additional, Pousão-Ferreira, P., additional, Gasco, L., additional, Gai, F., additional, Oliva-Teles, A., additional, and Enes, P., additional more...
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- 2022
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13. Effects of temperature and dietary protein level on hepatic oxidative status of Senegalese sole juveniles (Solea senegalensis)
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Castro, C., Pérez-Jiménez, A., Guerreiro, I., Peres, H., Castro-Cunha, M., and Oliva-Teles, A.
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- 2012
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14. Dietary protein requirement of sharpsnout sea bream (Diplodus puntazzo, Cetti 1777) juveniles
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Coutinho, F., Peres, H., Guerreiro, I., Pousão-Ferreira, P., and Oliva-Teles, A.
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- 2012
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15. Validation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery
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Gopaul, A, R Pentony, A, L Piong, C, Nossier, R, Hanna, J, Sabir, K, Y Eow, S, Ladak, N, Boersma, D, J Kamath, P, W Soh, T B, H Dyer, A, Y Chee, S, H Tan, I X, Kelliher, A, Scanlon, K, Adeusi, L, Howarth, N, Mccawley, N, O'Neill, A, R Jones, M, Saleh, R, Singh, A, O'Dwyer, N, C Mana, O, Gomez, H, Riba, L, Perez, J, Centeno, A, Ortega, C, E Ossola, M, Camarero, E, Martínez Illán, M, Aranda García, L, Lázaro Cardona, M, Montalvo Olmedo, C, Izquierdo Moreno, A, Cuenca Ramírez, A, Margarida, A, Pando, B, Liquete Marín, L, Pérez Calle, M, J Ramos Cordero, M, Sagredo Cuartango, A, Sánchez, E, Marcos Rodrigo, A, Fernandez, A, Curtis, C, Bosch, M, Triguero, D, Bosch Ramírez, M, De La Llave Serralvo, A, J Sánchez, M, Martín-Borregón, P, Quevedo, A, Martínez, J, M Marín, J, Rodríguez, P, Esteban Avendaño, I, Jiménez Relimpio, C, Lancho Lavilla, P, Blanco Bartolomé, I, Gómez Cano, I, Blasco Andrés, C, Abad-Motos, A, Marínez-Hurtado, E, Salvachua-Fernández, R, Muniesa, C, Avelino, L, Cholewa, H, Sancho-Muriel, J, Navasquillo, M, Navío, A, Abelló, D, De Jesus, M, Alvarez, E, Kefleyesus, A, Bugmann, A, M Piotet, L, Meijers, L, Tonchev, P, Tamosiunas, A, J Rottier, S, Negoi, I, R Bernado, I, Eftychiou, S, and L Lorenzon (ORCID:0000-0001-6736-0383) more...
- Abstract
Background: Postoperative acute kidney injury (AKI) is a common complication of major gastrointestinal surgery with an impact on short- and long-term survival. No validated system for risk stratification exists for this patient group. This study aimed to validate externally a prognostic model for AKI after major gastrointestinal surgery in two multicentre cohort studies. Methods: The Outcomes After Kidney injury in Surgery (OAKS) prognostic model was developed to predict risk of AKI in the 7 days after surgery using six routine datapoints (age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker). Validation was performed within two independent cohorts: a prospective multicentre, international study ('IMAGINE') of patients undergoing elective colorectal surgery (2018); and a retrospective regional cohort study ('Tayside') in major abdominal surgery (2011-2015). Multivariable logistic regression was used to predict risk of AKI, with multiple imputation used to account for data missing at random. Prognostic accuracy was assessed for patients at high risk (greater than 20 per cent) of postoperative AKI. Results: In the validation cohorts, 12.9 per cent of patients (661 of 5106) in IMAGINE and 14.7 per cent (106 of 719 patients) in Tayside developed 7-day postoperative AKI. Using the OAKS model, 558 patients (9.6 per cent) were classified as high risk. Less than 10 per cent of patients classified as low-risk developed AKI in either cohort (negative predictive value greater than 0.9). Upon external validation, the OAKS model retained an area under the receiver operating characteristic (AUC) curve of range 0.655-0.681 (Tayside 95 per cent c.i. 0.596 to 0.714; IMAGINE 95 per cent c.i. 0.659 to 0.703), sensitivity values range 0.323-0.352 (IMAGINE 95 per cent c.i. 0.281 to 0.368; Tayside 95 per cent c.i. 0.253 to 0.461), and specif more...
- Published
- 2022
16. Timing of nasogastric tube insertion and the risk of postoperative pneumonia: an international, prospective cohort study
- Author
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W., Gabbas G., Marziali I., Mazzocato S., Vergari R., Piazzai F., Kubolli I., Aggiusti A., Paolucci A., Ortenzi M., Olivieri M., Belluco C., Antona A. D., Basso S., Morino M., Mistrangelo M., Clerico G., De Santi G., Bitonti M. F., Frattalone M., Fico V., Santullo F., Belia F., Spinelli A., Marco M., Bevilacqua M., Tringali D., Bevilacqua E., Panizzo V., La Manna V., Migliore G., Aversano A., Fares Bucci A., Marino F., Carbone F., Incollingo P., Romano F. M., Zalla T., Baraghini M., Romoli L., Calussi M., Vellei S., Genzano C., Feroci F., Vita M., Barberis A., Serra D., Grassia M., Romelli M., Ruggiero S., Percassi A., Magri Piccinini A., Monti M., Magnoli M., Romano S., Gaetano P., Pilotta F., Baldassarre L., Bonati E., Aresu S., Saba A., Moretto G., Bacchion M., Casaril A., Inama M., Creciun M., Stella M., Gobatti D., Angelini M., Andolfi E., Miranda E., Scricciolo M., Provenza G., Cavallina G., Frezza B., Fontani A., Malatesti R., Pellicano G. 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J., Navarro Barrios A., Rodriguez Pedreno L., Garcia Moreno P., Garcia Gomez M., Rodrigues K., Platero Diago J., Veras Lista M., Rifa Terricabras S., Butler Sanz L., Alberch Camprubi E., Rico Ferrandez M., Puig Lao E., De Pablo Miro M., Alberca-Paramo A., Alia Verdejo T., Canete-Manzanares J., Molina-Florez M., Garcia Hernandez L. C., Orozco Nunez S., Suarez-Sanchez M., Martin-Fernandez J., Soriano Liebana M. M., Campo Betancourth C. F., Sevila Mico S., Fernandez A., Curtis C., Bosch M., Triguero D., Bosch Ramirez M., Ramayo Diaz N., Gonzalez Caraballo I., Pascual Vicente T., Orue-Echebarria M. I., Sanchez-Calvo L., Wang D., Trueba-Collado C., Morales Bernaldo de Quiros J. T., Lima Pinto F., Nunez OSullivan S., Ramos Jimenez F. A., Perez Ortega A., Trujillo Barbadillo A., Romero Pujana E., Fernandez Illera M. V., De La Llave Serralvo A., Mestres N., Cuello E., Merichal M., Sierra J. E., Escoll J., Rufas M., Pinillos A. I., Ortega J., Vivas Angeles P., Vives Figueras R., Baena Sanfeliu E., Campillo Alonso B., Alberich Prats M., Duran Arrocha J., Cornella Garceso N., Uribe Galeano C., Delisau Puig O., Castro A., Codony Bassols C., Fernandes N., Garcia Adamez J., Caula Freixa C., Sanchez M. J., Martin-Borregon P., Quevedo A., Martinez J., Marin J. M., Rodriguez P., Garcia Orozco J. J., Ferrusola Diaz D. A., Garcia Jimenez M. L., Castro Diez L., Mosquera Fernandez C., Alonso Batanero E., Cifrian Canales I., Calzada M. G., Recuenco C. B., Martin M. C., Esteban Avendano I., Jimenez Relimpio C., Lancho Lavilla P., Blanco Bartolome I., Gomez Cano I., Blasco Andres C., Alonso-Poza A., Dieguez B., Losada M., Gilsanz C., Garcia-Vico A., Roman-Rando A., Sanchez-Galvez M. A., Bersabe-Alonso I. M., Vadillo-Bohorquez A., Gutierrez Rios R. D., Eizaguirre Ubegun M., Novo Sukia I., Uribe Isado M., Ibanez Alda M., Pastor Idoate C., Abad-Motos A., Marinez-Hurtado E., Salvachua-Fernandez R., Padilla Zegarra E. D., Franco M., Martinez A., Ramos Martin P., Mate Mate P., Marcano Chavez C., Ayllon H., Jeri-McFarlane S., Soldevila-Verdeguer C., Pineno-Flores C., Ambrona-Zafra D., Fernandez-Vega L., Gil-Catalan A., Craus-Miguel A., Pujol-Cano N., Sena-Ruiz F., Gomez Jurado M. J., Alberti Delgado P., Bordanova Reverter A., Belzunce-Capo J. F., Verdaguer Tremolosa M., Lin Q., Muniesa C., Avelino L., Cholewa H., Sancho-Muriel J., Navasquillo M., Navio A., Abello D., De Jesus M., Alvarez E., Garcia J. M., Gil A., Giordano H. E., Mignon G., Vanoni A., Henkens A., Jarrar G., Odovic M., Willemin M., Milliet O., Hahnloser D., Demartines N., Teixeira H., Pittet O., Haller M. L., Huot A., Kefleyesus A., Bugmann A., Piotet L. M., Meijers L., Kurtoglu G. K., Sel E. K., Isler V. C., Yilmaz B. S., Adiyaman C., Kara M., Demirkaya H. C., Korkmaz H. K., Pektas A. M., Guner B., Islek E. C., Tombul H. B., Boztug C. Y., Tinaz A., Yilmaz M., Karaman Y., Akin F. A., Dansuk S., Bascavus M., Kaya M., Kutlu B., Seker M. 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J., Livie V., Ibrahim B., Khalil M., Pooley G., Shishkin B., Docherty J., Southgate A., Coomes A., McGee F., Flanagan S., Tan Q. J., Anwar H., Clough R., Chrisp B., Cassels J., Cross G. W. V., Mercer L., Mercer C., Refalo A., Hadley R., McTighe A., Farrow F., Brodie A., Davis G., Shah D. R., Bowers C., Patel S., Morice O., Burzic A., Cheung J., Shashidhara A., Theodoraki G., Birk J., Ong A., Ng M. P. E., Wong R. T. W., Maese S., Yeap B., Iqbal Z., Rojoa D. M., Cabaleiro Barciela C., Ruddy C. M., Lindwe S., Qamar Y., Chuita S., Melaugh T., Hall J. D., Kouli O., Hassane A. S. I., Azhar A. W., Tan T. K., Perchard W., Scurr T., Campbell E., Kelk L., Ghosh A., Gibbins A., Mala D., Loizidou A., Hall O., Mecia L., Hew C., Varathan K., Tong L., Chandrasekar B., Buchanan E., O'Connell M., Kwak S. Y., Ong E. H., Gardner S., Lim J., Maden C., Illahi M., Xuan Tan Z., Stahl R., Stahl J., Hickman A., Collett D., Goolam-Mahomed Z., Allen B., Atiyah A., Ahmad H., Jones J., McGregor O., Ogundiya E., Boulbadaoui A., Kirnon-Jackman O., Lim Q. X., Peckham H., Yeoh T., Yong S. Q., Chen J. Y., Siva S., Sam Z. H., Gilani M., Goh Y. N., Muthukumar M. G., Phillips S., Tjoakarfa J., Giri A., Suresan S., Thomas P., Johnson T. A., Williams R. I., Rashid A., Kushairi A., Rais A., James A., Bugelli M., Chechelnitskaya Y., Sandhu N., Tandon R., Gray M., Kumar A., Ciurleo C., Nyamali I., Hiremath S., Sinha S., Chowdhary M., Bradley E., McTiernan M., Macdonald S., Sharkey S., McLaughlin N., Amey C., Kraria L., Skan O., Kind C., Tupper P., Van Rhee C., Honeyman S. I., Menon G., Jegatheeswaran L., Madhavan A., Warne M., Malcolm F. L., Lessware T., Wilkerson H. T., Chatterjee-Woolman S., Yoong A., Ahmed W. U. R., Longshaw A., Flannery O., Green R., Leaning M., Cragg J., Sharriff H., Doherty C., Kwan K. W. L., Sanders-Crook L., Bhatia S., Eames S., Lewis F., Kirupananthan P., Boh Z. Y., Dass S., Soma A., Newton A., Hill M., Shafiq Y., Brkljac M., Boyce L., English W. J., Lam S., Chipeta C., Jain C., Garofalidou T., Novotny S. A., Locke S., Bowman C., Begaj A., Murphy C., Radcliffe K., Chong J. T., Jeffrey E., Chaudhury N., Rajendran K., Akbar Z., Walters B., Kulendrarajah B., Tran N., Shrestha S., Parmar S., Gallagher C., Hennessy L., Pentti E., Badhrinarayanan S., Fung A., Mansoor M., Kenny R., Kan P., Lee D. E., Khosla S., Samake M., Shaban F., Aftab R., Gough M., Woodburn B., Vayalapra S., McMurrugh K., Jimulia D., Deol S., Pike S., Embury-Young Y., Patel M., Kilgallon E., Keating R., Walsh A., Khan H., Logue G., Orekoya M., Alasmar M., Charalambides M., Clave Llavall A., Williamson E., Bharwada Y., Zearmal S., Evans H., Panikkar M., de la Cruz G., Caplan J., Ruparelia A., Tanvir T., Soare C., Pang Y. L., Trotter J., Zaidi A., Thakrar V., Pulickal P., Ahmed H., Parnell J., Lennock S., Ford V., Brignall R., O'Neill D., Hanna R., Kane R., Nicola M., Rajput K., Xiao Y., Michael S., Wright E., Juniper S., Thompson E., Hoskyns L., Kanitkar A., Ross C., Unsworth A., Rshaidat H., Demarre K., Chiang A., Bareh A., van Dellen J., Faqihinejad C., Gadhvi A., Grant R., Lewsey J., Morris A., Martin H., McClarty C., Sanyal S., Alsaif A., Palkhi A., Bhopal S., Vishnu K S., Papanikolaou A., Mitra A., Nur A., Ali F., Burford C., Huq T., Irwin E., Matthews L., Ngu W. S., Hosfield T., Muneeb F., Page O., Zeb E., Al-Azzawi A., McIntosh J., Vucicevic A., Hughes M., Brooks L., Fanibi B., Dixon M., Njoku P., Morris D., Jobson J., Chowdhury H., Alawode D. O. T., Wynell-Mayow W., Udayachandran V., Alsoof D., Ekert J., Joseph N., Zulkefley N., Hunt G., Christodoulou T., Wright O., Soman S., Jamal M., Beqiri S., Borgas P., Christie S., Pereira F., Browne S., Yiu J., Dworkin A., Brayley J., Palmer A., Charalambos M., Jones C. S., Toner S., Cowden R., Lee L., Nicol P., Holman O., Imtiaz M., Albert V., Leung S. P., Erotocritou M., Stroud R., Wilkin R., Thomson W., Mackee L., G N., Bei Y., Mckenna Favier S., Ibrahim A., Kler A., Reynolds L., Mohamed S. H., Majeed Y., Fakim B., Jones A., Liversedge G., Carrington Z., Windebank J., Izzarina A., Akbani U., Craven J., Aldarragi A., Harding S., Millward A., Bedford M., Gopalan V., Midgen A., Khadka P., Cheng O., Taneja S., Manobharath N., Kok J. Y., Lim D. W. E., Buick T., Boland M., Piya S., Devlin R., Fairfield C. J., George R. J., Rahi M., Zaman S., Hajiev S., Ross T., Crisp E., Thompson C., Charalambous A., Hollywood J. L., Hammond R. F. L., Matthews J., Mendonca V., Spinty J., Khan K., Cheng J., Glynn N., Muhammad U., Khan M., Anderson L., Mccormack K., Mak J., Patrawala S., Milinkovic N., Schofield R., Chauhan M., Hartley L., Hind J., Nelson L., Ratnasingham D., Whitehead T., Dimitriadis S., Marshall K., Flint E. J., Horner C., Heybourne A., Morgan H., Wickstone C., Panagiotou D., O'Connell E., Dean K., Iqbal R., Walsh L., Yu N., Rana N., Massie E., Ng J., Jung M., Lee Y. D., Harris M., White S., Boev B., Tonchev P., Prochazka V., Skalicky A., Ravn S., Ojakaar A., Dorr-Harim C., Koutserimpas C., Giraudo G., Armellini A., Ruzzenente A., Mazzeo C., De Padua C., Realis Luc A., Maroli A., Giani I., Cufari M. E., Vitali M., Gusai G. P., Quattromani R., Virgilio E., Berti S., Di Mola Ospedale SS Annunziata F. F., Papagni V., Tuminello F., Vittori L., Longheu A., Loche G. A., Braccio B., De Luca E., Resta G., Ancans G., Tamosiunas A., Petrulionis M., Andrejevic P., Stellingwerf M. E., Abdulrahman N., van de Pas K. G. H., Thomas G., Brandsma A. M., Davids J., Rottier S. J., de Roy van Zuidewijn D., Hawkins R., Ong H. I., Li Y., Desmond B., Winstanley J., Martins M., Americano M., Frade S., Senhorinho R., Peixoto R., Alves-Vale C., Lamas M., O'Connor D. B., Hoo M., Gopaul A., Scanlon K., O'Dwyer N., Jovanovic M., Panyko A., Van Vuuren S., Centeno A., Bernado I. R., Paniagua Garcia Senorans M., Gonzalez Amor L., Cuenca Ramirez A., Abrisqueta J., Estaire Gomez M., Arroyo A., Cerdan C., Gomez Romeu N., Enriquez-Navascues J. M., Collado-Roura F., Curchod P., Gaspar S., Imadalou L., Mutlu D., Akyol C., Uygur F. A., Eray I. C., Biyiklioglu O., Cetin M. F., Isik A. E., Karip B., Dogan H., Sarigul L., Tunc E., Aydin T., Bodur S., Karabulut K., Francis A. A., Al-hadithi A., To N., Lau I. S. F., Smith E., Mahapatra S., McAuliffe O., Imam L., Akram B., Hossaini S., Davies R., Ko M., Collins J., Pandya A., Reilly S., Archer J., Auty C., Roche C. D., Livie J., Chaudhry F. A., Ntakomyti E., Diallo R., Bylinski T., Wright J., Masiha E., Tung J., Shirazi B., Neilson A., Epton S., Patel N., Trussell S., Couldrey A., Donnelly C., Eftychiou S., Glasbey, J, Bibi, S, Pata, F, Ozkan, B, Van Straten, S, Hodson, J, Chapman, S, Blanco-Colino, R, Pellino, G, Sgro, A, Soares, A, van Elst, T, Nepogodiev, D, Borakati, A, Bath, M, Yasin, I, Mclean, K, Arthur, T, Kovacevic, M, Delibegovic, S, Karamanliev, M, Swamad, M, Zebrak, R, Paramasivam, R, Martensen, A, Larsen, H, Radeker, L, Frey, P, Kechagias, A, Venara, A, Duchalais, E, Ioannidis, A, Frinzaq, G, Pasquali, S, Simioni, A, Farina, V, Podda, M, Lorenzon, L, Itsurg, I, Schaeff, V, Otto, A, Jakubauskas, M, Chu, M, Fagan, P, Wells, C, Alagoa Joao, A, Juloski, J, Perez-Ajates, S, Anabitarte Bautista, O, El Kasmy, Y, Espin-Basany, E, Clerc, D, Ciubotaru, C, Popescu, S, Yanishev, A, Lee, S, Yagiz Sen, A, Aktas, M, Baki, B, Yuksek, B, Kamarajah, S, Khaw, R, Mills, E, Goodson, R, Thakral, N, Collaborative, S, Ablett, A, 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A., Anania M., Pulighe F., Cruccu A., Murru M. L., Massaiu C., Balestra F., Pazzona M., Giannella A., Santangelo M., Frangella F., Magagnano D., Liberatore P., Brenna R., Giani A., Tirotta F., Famularo S., Angrisani M., Ceresoli M., Rondelli F., Angelucci G. P., Scaramuzzo R., Larcinese A., Fioriti C., Picone E., Nardi M., Castagnoli G., Bartoli A., Bellochi R., Spaziani A., Conti D., Poponesi V., Trippetti M., Amicucci S., Tazza G., Procacci P., Giovannini F., Basile E., Caristo G., De Nardi P., Rosati R., Marcocci G., Vignali A., Malerba M., Percivale A., Ghazouani O., Reggiani L., Spirito C., Moschetta G., Cosmi F., Romeo G., Gasparrini M., Sucameli F., Gennai A., Moggia E., Bianchi C., Bonfante P., Macina S., Feleppa C., Imperatore M., Tenconi S. M., Rausei S., Maioli D., Marchionini V., Sparta C., Mura F. A., Barmina M., Lorettu A., Rettaroli C., Mastino G., Ruggiu G. V., Mura G. A., Perrone B. 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L., Jelovskis I., Deksnis D., Bauermeister Potts O., Slimbajevs T., Samalavicius N. E., Nutautiene V., Zeromskas P., Jurgaitis J., Aliosin O., Slepavicius A., Eismontas V., Kybransiene M., Dulskas A., Kuliavas J., Kavaliauskas P., Kavaliauskaite R., Poskus E., Danys D., Kryzauskas M., Mikalauskas S., Rackauskas R., Drungilas M., Jotautas V., Strupas K., Cachia C., Cefai C., Youssef Y., Degaetano D., Debono S., Sammut M., Cassar J., Sammut K., Looijen R. C., Becker M. A. J., Comert D., te Molder L., Tromp J., Matthee E., Tissen Y. M., Brinkhuis E., de Vries H. S., 't Hart E., Beckers K., Bekker Y., Kakar S., van Smaalen T. C., Veen O. C., Dingemans S. A., van den Brink L. C., Vijgen G. H. E. J., van de Voort E. M. F., van der Pool A., van Rest K. L. C., Haak T., Sluijpers N. R. F., Molenaar C. J. L., Gordinou de Gouberville M. C., Saleh S., Mens M. A., Hoeks E. M., Nieuwenhuizen S., van Praag E. M., Westerduin E., Smit M. P. C. M., van der Lely S. J., Nasimi B., Gerdsen M., Stijns R. C. H., Leow T. Y. S., Penningnieuwland G., de Ruiter A., Ribbers T., Aarts C. A. M., Tulek M. S., de Jonge J., Kocak S., Alqethami H. J., Constansia R., van Elst P. C., Tissink M. W., Gruter A., Vroom Y., Voeten D. M., Feenstra T., Azzahhafi J., Bofarid S., Kip M., Saleh W., Franssen S., Boon C. L., Franssen R. J. M., Romaen I., Jense M. T. F., D'Souza J., Pascoe R., Scott A., Stark E., Mulholland K., Lau W. K., Smith B., Adams S. I. B., Shah N., Ling E., Young J., Jacobson A., Macfater H., Chen S. Y., Kilpatrick K., Kim D. H., Dixon S., Yassaie S., Welman D., Coulter J., Morreau M., Li E., Rankin A., Winders J., Skipworth C., Stanfield B., Henderson N., Chuang A., Maskill L., Ker H., McLaughlin S. J. P., Kearney J., Sprosen H., Kerckhoffs P., Alsadat R., Cherry R., Chapman D. A., Singh N., Clucas A., Gatenby G., Kelly B., Ruppeldt P., McIntosh N. D., Koh S., Wilms H., Dalzell F., Tewhaiti-Smith J., Kader T., Yam S. T., Dahya D., Hardie Boys M., Fleischl W., Skavysh A., Mouldey K., Hu R., Edwards S., Matthews C., Aitken E., Walker M., Tome M., Patrocinio S., Amado F., Batista A., Seabra J., Praxedes V., Monteiro N., Martins I., Santos T. C., Lages R. R., Pimentel A., Sa T., Bernardes F. M., Saraiva P., Almeida J., Mendes M., Fernandes V., Ribeiro A., Soares D., Martins T., Miguel I., Martins J., Cunha M. F., Melo J., Veiga D. N., Rachadell J., Vareda R., Roseira J., Aveiro D., Couto M., Loureiro A. R., Louro H., Queiros T., Castro B., Fonseca S., Carvalho L., Torre A. P., Amado A., Leite M., Miranda P., Cunha C., Silva R., Pina S., Paixao I., Orelhas L., Santos J., Pacheco A., Rocha A. F., Jervis M. J., Pedro V., Paixao V., Guerreiro A., Melo D., Correia D., Capella V., Moinhos T., Silva M., Silva A. G., Galvao D., Mora A., Bettencourt R., Costa F., Gil I., Morgado J., Monica I., Oliveira S., Ribeiro H., Guimaraes N., Duarte M., Miranda J., Martins S. F., Parreira R., Faustino A., Medeiros N., Castro R., Soares B., Resendes M., Almeida P., Cruz A., Vaz Pinto G., Sousa D., Costa Santos D., Silva F., Fialho G., Reia M., Pratas N., Costa C., Costa J., Morais S., Machado A., Horta V., Rocha-Melo M., Patricio J., Pereira M., Lima R., Cinza A. M., Oliveira J., Velez C., Borges F., Simoes J., Botelho P., Cismasiu B., Alves D., Dias B., Goncalves J. P., Valente P., Freire L., Saraiva R., Moreira M., Fragoso M., Guimaraes J., Cruz G., Ribeiro J., Borges da Ponte I., Almeida S., Martins A. R., Louro T., Morgado M., Ferreira A. S., Alves M., Oliveira N., Lerias R., Estalagem I., Botelho C., Bartolo J., Fidalgo Antunes C., Cabral F., Brito Silva F., Dias Matos A., Santos M., Cunha R., Sousa M., Canotilho R., Correia A. M., Martins P. C., Jardim J. A. M., Domingos S. P., Baiao J. M., Rocha B. S., Lopes N. M. R. O., Jordao D. M., Angelo M. D., Caroco T., Gomes J. R., Monteiro R. G., Varghese S., Boyle E., Aljohmani L., Alexander J., Graziadei V., McCaughey C., Jain A., Ramanayake H., Sabnani R., Colon L. F., Bansal N., Stephens I., Tan R., Sharma S., Doherty G., Fenn S., Mulhare E., Walsh M., Leavey C., Costigan O., Griffin S., Dockry E., Khogali E., Aly A. K., McPhedran R., O'Gorman D., Vermeulen D., Dervan L., Kang S. J., Dixon O., Morrissey E., Compton M., Pentony A. R., Piong C. L., Nossier R., Hanna J., Sabir K., Eow S. Y., Ladak N., Boersma D., Kamath P. J., Soh T. B. W., Dyer A. H., Chee S. Y., Tan I. X. H., Kelliher A., Adeusi L., Howarth N., McCawley N., O'Neill A., Jones M. R., Saleh R., Singh A., Senaratne R., Kakodkar P., Balasubramanian I., Al-Salihi A., Vyas V., Vedadi A., Popescu S. S., Piras K., Ciubotaru C. I., Romanova E., Ponomarev N., Savchenko A., Luzan R., Lutovinova E., Gavrilina A., Barkovskaya A., Kudelkina N., Topchubaev D., Radulovic R., Milosevic K., Bojicic J., Gencic M., Jankovic U., Zubowicz M., Suchan P. K., Gerstmeier J., Brazitikou E., Fytrou E., Celik M., Dubovsky M., Schmalenbeck J., Sautter S. C., Ceyran H., Fitchat N., Mathebula S., Chauke J., Mculu W., Ngwenya Z., Withey K., Piperidis A., Toyi Y., Nicolaides A., Jaffer T., Sparke A., Van Staden N., McDuling C. R., Claassen L., Kruger C., Weyers J., Lecler J., Yebes A., Mana O. C., Gomez H., Riba L., Perez J., Casaval Cornejo L., Vicente Rodriguez I., Jimenez Escovar F., Calvo Fernandez M., Portugal Martinez A., Badiola Bergara I., Landaluce Olavarria A., del Pozo Andres E., Samartin Toimil C., Primo Alvarez J. C., Rodriguez Fernandez L., Ortega C., Ossola M. E., Camarero E., Martinez Illan M., Aranda Garcia L., Lazaro Cardona M., Montalvo Olmedo C., Livianos Arias-Camison P., Nieto Arranz J. M., Mateos Sexmero M. J., Diego Alonso E., Izquierdo Moreno A., Margarida A., Pando B., Liquete Marin L., Perez Calle M., Ramos Cordero M. J., Sagredo Cuartango A., Sanchez E., Marcos Rodrigo A., Martinez Diaz J. M., Ruiz Manzanera J. J., Navarro Barrios A., Rodriguez Pedreno L., Garcia Moreno P., Garcia Gomez M., Rodrigues K., Platero Diago J., Veras Lista M., Rifa Terricabras S., Butler Sanz L., Alberch Camprubi E., Rico Ferrandez M., Puig Lao E., De Pablo Miro M., Alberca-Paramo A., Alia Verdejo T., Canete-Manzanares J., Molina-Florez M., Garcia Hernandez L. C., Orozco Nunez S., Suarez-Sanchez M., Martin-Fernandez J., Soriano Liebana M. M., Campo Betancourth C. F., Sevila Mico S., Fernandez A., Curtis C., Bosch M., Triguero D., Bosch Ramirez M., Ramayo Diaz N., Gonzalez Caraballo I., Pascual Vicente T., Orue-Echebarria M. I., Sanchez-Calvo L., Wang D., Trueba-Collado C., Morales Bernaldo de Quiros J. T., Lima Pinto F., Nunez OSullivan S., Ramos Jimenez F. A., Perez Ortega A., Trujillo Barbadillo A., Romero Pujana E., Fernandez Illera M. V., De La Llave Serralvo A., Mestres N., Cuello E., Merichal M., Sierra J. E., Escoll J., Rufas M., Pinillos A. I., Ortega J., Vivas Angeles P., Vives Figueras R., Baena Sanfeliu E., Campillo Alonso B., Alberich Prats M., Duran Arrocha J., Cornella Garceso N., Uribe Galeano C., Delisau Puig O., Castro A., Codony Bassols C., Fernandes N., Garcia Adamez J., Caula Freixa C., Sanchez M. J., Martin-Borregon P., Quevedo A., Martinez J., Marin J. M., Rodriguez P., Garcia Orozco J. J., Ferrusola Diaz D. A., Garcia Jimenez M. L., Castro Diez L., Mosquera Fernandez C., Alonso Batanero E., Cifrian Canales I., Calzada M. G., Recuenco C. B., Martin M. C., Esteban Avendano I., Jimenez Relimpio C., Lancho Lavilla P., Blanco Bartolome I., Gomez Cano I., Blasco Andres C., Alonso-Poza A., Dieguez B., Losada M., Gilsanz C., Garcia-Vico A., Roman-Rando A., Sanchez-Galvez M. A., Bersabe-Alonso I. M., Vadillo-Bohorquez A., Gutierrez Rios R. D., Eizaguirre Ubegun M., Novo Sukia I., Uribe Isado M., Ibanez Alda M., Pastor Idoate C., Abad-Motos A., Marinez-Hurtado E., Salvachua-Fernandez R., Padilla Zegarra E. D., Franco M., Martinez A., Ramos Martin P., Mate Mate P., Marcano Chavez C., Ayllon H., Jeri-McFarlane S., Soldevila-Verdeguer C., Pineno-Flores C., Ambrona-Zafra D., Fernandez-Vega L., Gil-Catalan A., Craus-Miguel A., Pujol-Cano N., Sena-Ruiz F., Gomez Jurado M. J., Alberti Delgado P., Bordanova Reverter A., Belzunce-Capo J. F., Verdaguer Tremolosa M., Lin Q., Muniesa C., Avelino L., Cholewa H., Sancho-Muriel J., Navasquillo M., Navio A., Abello D., De Jesus M., Alvarez E., Garcia J. M., Gil A., Giordano H. E., Mignon G., Vanoni A., Henkens A., Jarrar G., Odovic M., Willemin M., Milliet O., Hahnloser D., Demartines N., Teixeira H., Pittet O., Haller M. L., Huot A., Kefleyesus A., Bugmann A., Piotet L. M., Meijers L., Kurtoglu G. K., Sel E. K., Isler V. C., Yilmaz B. S., Adiyaman C., Kara M., Demirkaya H. C., Korkmaz H. K., Pektas A. M., Guner B., Islek E. C., Tombul H. B., Boztug C. Y., Tinaz A., Yilmaz M., Karaman Y., Akin F. A., Dansuk S., Bascavus M., Kaya M., Kutlu B., Seker M. C., Erten V., Memis U., Kocak Z. B., Karapinar Y. E., Fakirullahoglu M., Koseoglu E., Yeni M., Aykun N., Agca M. H., Bilen C., Kilinc I., Atar C., Kilic V., Aktuna C., Aba M., Alim Y. E., Binbuga M., Kurklu O., Ceylan C., Yilmaz S., Calar S. N., Yildirim N., Yavuz G., Can B., Cesmeli E., Kus D., Kavar R. C., Cevlik A. D., Cengiz U., Turk E. G., Yilmaz I., Erdonmez H., Gursoy F., Kara H., Onsal U., Ozbek M., Kasar P. A., Ipor A., Ozen D., Olmez M., Altintas E., Toklu R., Saricicek T., Tipi O. U., Benli G. E., Tasdelen I., Tura A., Ucar A., Ekci B., Bilgili A. C., Kiraz I. N., Aksoy H., Basak A., Erdem M., Kayacan S., Sahin C., Uysal M., Karakus K., Altiner S., Demirci Z. S., Eren E., Yavas M., Aksoy A. B., Karagoz E., Sabanci R., Tumer S. S., Kargici K., Banaz T., Abdulrahman S. M. F., Yesilsancak M., Yanikoglu E., Karabulut A., Yilmaz D., Kuyumcu O. F., Kutluk F., Emiroglu B., Mollavelioglu B., Gereklioglu D., Guler M., Toprak S., Afsar H. B., Guler S. E., Alizade E., Alemdag G., Ulusahin M., Gul E. B., Yildirim R., Semiz A., Bektur G., Tomas K., Yarenci E., Demiroglu Y., Sunal A., Baykan B., Abbasguliyev H., Mutlu V., Mahmoudi Y., Dossa S. A. A., Mizan S. R., Demirtas B., Cavus T., Yuksek A., Mazlum S. S., Yelkenci C., Baran T., Satilmisoglu M., Sahin A. Z., Kilinc A., Isik K., Yumurtaci O., Emin A., Girit C., Yildirak M. K., Senyigit E., Guldag A., Soyleyici B., Aytin Y. E., Akay F. E., Iskan N. G., Mutlu B., Sunay A. O., Tie-Gill T., Ramsay G., De Paola L., McGuckin S., Alshakhs A., Ahmeidat A., Goergen N., Ali Z., Mullarkey L., Walshe R., Lewis E., Berry B., Moneim J., Mookerjee S., Christy S., Ojofeitimi O., Carroll L., Hylands A., Delaugere L. P., Reveendran D., Coulter C., Ralston C., Laverty L., Gallagher P., Ahmed A., Yeo Y. Q., Elliott D., Bennett J., Mcnamara M., Sivarajah S., Dunmore C., Aitken G., Nair M., Aly M. H., Buari M., Ahmed K., Sheikh Z., Monks M., Lehmann J., Rotimi O., Bell T., Limnatitou D., Gormley S., Taleongpong P., Patel V., Macgregor L., Amini S., Turner C., Dwyer-Hemmings L., Busuttil A., Powell J., Hensher C., Vivian F., Wcislo K., Millar Z., Hirosue S., Ogunmwonyi I., Nakakande D., Gaze H., Nirmalanantha A., Bin Amran M. A., Foulkes A., Jones N., Pillai S., Khoury G., Powell T., Maleyko I., Sangheli A., Ransome M., Isse M., Aromolaran O., Bholah H., Anbarasan J., Rehman S., Hu E., Timms S., Reynolds W., Hotchkies A., Misra V., Theocharidou L., Malik T., Janmohamed I., Carhart B., Khan A., Hullait R., Rylance A., Butt S., Leathes J., Philip Rajathasan T., Jeddy H., Kyaw H. A., Wong N., Karelia S., Clements J. M., Rainey M., Joshi N., Rahman A., Gallagher M., Rebuffa N., Abdelgalil R., Siaw Yen Lai R., Laurence N., Thomas S., Green C., Frostick R., Khera R., Povey M., Wong H. L., McCusker C., Hlukha L., Pike G., Kamel F., Thakkar R., Donaldson C., Sequeira Campos M., Armitage M. N., Hussain A. S., Hardy B., Hassan Serry M. Y., Bradbury M., Osunronbi T., Tam L. Y. C., Khanan Kaabneh A., Lawther J., Fisher P., Tribedi T., Moosa A., Ramdin A., Goble M., Downs E., Wheldon L., Baggus E., Mandal A., Nayeem A., Ahmed S., Fradley W., Wilson C., Gallagher S., Criswell T., Ward J., Mukkavilli A., Stubbs B., Fordyce W., Suchdev N., Wei Lim S., Sookramanien S. R., Chan A., Bointas G., Paul M., Ward K. L., Bagnall M., Pherwani S. A., Wang K., Mitchell L., Heyworth J., Ayyar S., Polson R., Mackenzie E., Doyle N., Habib Z., Zardab M., Sartaj F., Farooq H., Tabibi M., Drury D. J., James S. J., Barnett R., Teasdale A. B., Richardson E. T. J., Thomas D. A., Williams R. L., Najabat-Lattif H. F., Cahya E., Lou G., Coyle M., Homyer K., Zhu L. Y., Woods M., Chang J., O'Callaghan H., Suchett-Kaye I., Mihailidis T. H., Alawattegama H., Seite E., Barrett A., Riordan E., Lam W., Dowdeswell M., Mulvenna C., Awokoya O., Gurowich L., Dhera K., Hayat S., Tincknell L., Spazzapan M., Teeling F., Sysum K., Latter J., Latter M., Khan S., Guruswamy M., Beedham W., Brazier E., Elghobashy M., Bajaj M., Mann H., Etel E., Woodmass M., Hayden H., Ali Y., Husain S., Arnold A., Pedersen A. C., Cunha P., Ahmed M., Al Zawawi S., Kudva V., Theodoropoulou K., Miscampbell M., Robinson A. V., Johnston J., Dharni A., Lamb S., Westerman T., Evans E., Campbell L., Gillespie M., Cheong C. M., Kulathevanayagam K., Varghese A., Ike S. I., Chu T. S. M., Baljer B., Mogg J. A. W., Rai P., Claireaux H. A., Williams M., Smillie R., Goetz J., Appleby E., Fadipe T., Vaughan-Burleigh S., Puri G., Hussain P., Flather R., Cutler A., Pathak S., Sheldon J., Collicott T., al-Ausi M., Jovaisaite A., Shah S. M., Khalid N., Gutmann D., Davison S., Alame Y. J., Syed L., Owen W. J., Ahsan S. D., Anthony-Uzoeto U., Macleod Hall C., Zheng S., Wynter K., James C., Sapre D., Ghosh R., Baird J., Cockburn L., Blackwood O., Simpson W., Jeong S., Bishop S., Bate R., Hobson C., Adam A. H., Redclift C., Do J., Adeleye O., Poli F., Batterham A., Brown S., Parekh J. N., Clay W., Pieri K., Jackson A., Saxena A., Gurung B., Oyebola T., O'Brien F., Djeugam B., Gardezi S., Ul-Hasan S., Martin-Hernandez M. P., Sisley M., Modi S., Antakia R., Elbayouk A., Soh Y. J., Mather J., Yusuf Z., Al-Sarraf Z., Naja M., Rassool S. B., Convill J., Nikookam Y., Warsame A., Pace C., Kiandee M., Ridwan R., Carey C., Hirri F., McMillan M. J. A., Ling J. J., Pendelbury L., Kerimzade K., Tang A., Howard E. O., Humayun S., Wadsworth O. J., Tan K., Abdelhameed F., Haglund C., Radnaeva I., Hu N., Rambhatla S., Waldron D., Madahar P., Malik S., Meney L. C., Ibrahim I., Kang C. K., Chiu J. Z. J., Livie V., Ibrahim B., Khalil M., Pooley G., Shishkin B., Docherty J., Southgate A., Coomes A., McGee F., Flanagan S., Tan Q. J., Anwar H., Clough R., Chrisp B., Cassels J., Cross G. W. V., Mercer L., Mercer C., Refalo A., Hadley R., McTighe A., Farrow F., Brodie A., Davis G., Shah D. R., Bowers C., Patel S., Morice O., Burzic A., Cheung J., Shashidhara A., Theodoraki G., Birk J., Ong A., Ng M. P. E., Wong R. T. W., Maese S., Yeap B., Iqbal Z., Rojoa D. M., Cabaleiro Barciela C., Ruddy C. M., Lindwe S., Qamar Y., Chuita S., Melaugh T., Hall J. D., Kouli O., Hassane A. S. I., Azhar A. W., Tan T. K., Perchard W., Scurr T., Campbell E., Kelk L., Ghosh A., Gibbins A., Mala D., Loizidou A., Hall O., Mecia L., Hew C., Varathan K., Tong L., Chandrasekar B., Buchanan E., O'Connell M., Kwak S. Y., Ong E. H., Gardner S., Lim J., Maden C., Illahi M., Xuan Tan Z., Stahl R., Stahl J., Hickman A., Collett D., Goolam-Mahomed Z., Allen B., Atiyah A., Ahmad H., Jones J., McGregor O., Ogundiya E., Boulbadaoui A., Kirnon-Jackman O., Lim Q. X., Peckham H., Yeoh T., Yong S. Q., Chen J. Y., Siva S., Sam Z. H., Gilani M., Goh Y. N., Muthukumar M. G., Phillips S., Tjoakarfa J., Giri A., Suresan S., Thomas P., Johnson T. A., Williams R. I., Rashid A., Kushairi A., Rais A., James A., Bugelli M., Chechelnitskaya Y., Sandhu N., Tandon R., Gray M., Kumar A., Ciurleo C., Nyamali I., Hiremath S., Sinha S., Chowdhary M., Bradley E., McTiernan M., Macdonald S., Sharkey S., McLaughlin N., Amey C., Kraria L., Skan O., Kind C., Tupper P., Van Rhee C., Honeyman S. I., Menon G., Jegatheeswaran L., Madhavan A., Warne M., Malcolm F. L., Lessware T., Wilkerson H. T., Chatterjee-Woolman S., Yoong A., Ahmed W. U. R., Longshaw A., Flannery O., Green R., Leaning M., Cragg J., Sharriff H., Doherty C., Kwan K. W. L., Sanders-Crook L., Bhatia S., Eames S., Lewis F., Kirupananthan P., Boh Z. Y., Dass S., Soma A., Newton A., Hill M., Shafiq Y., Brkljac M., Boyce L., English W. J., Lam S., Chipeta C., Jain C., Garofalidou T., Novotny S. A., Locke S., Bowman C., Begaj A., Murphy C., Radcliffe K., Chong J. T., Jeffrey E., Chaudhury N., Rajendran K., Akbar Z., Walters B., Kulendrarajah B., Tran N., Shrestha S., Parmar S., Gallagher C., Hennessy L., Pentti E., Badhrinarayanan S., Fung A., Mansoor M., Kenny R., Kan P., Lee D. E., Khosla S., Samake M., Shaban F., Aftab R., Gough M., Woodburn B., Vayalapra S., McMurrugh K., Jimulia D., Deol S., Pike S., Embury-Young Y., Patel M., Kilgallon E., Keating R., Walsh A., Khan H., Logue G., Orekoya M., Alasmar M., Charalambides M., Clave Llavall A., Williamson E., Bharwada Y., Zearmal S., Evans H., Panikkar M., de la Cruz G., Caplan J., Ruparelia A., Tanvir T., Soare C., Pang Y. L., Trotter J., Zaidi A., Thakrar V., Pulickal P., Ahmed H., Parnell J., Lennock S., Ford V., Brignall R., O'Neill D., Hanna R., Kane R., Nicola M., Rajput K., Xiao Y., Michael S., Wright E., Juniper S., Thompson E., Hoskyns L., Kanitkar A., Ross C., Unsworth A., Rshaidat H., Demarre K., Chiang A., Bareh A., van Dellen J., Faqihinejad C., Gadhvi A., Grant R., Lewsey J., Morris A., Martin H., McClarty C., Sanyal S., Alsaif A., Palkhi A., Bhopal S., Vishnu K S., Papanikolaou A., Mitra A., Nur A., Ali F., Burford C., Huq T., Irwin E., Matthews L., Ngu W. S., Hosfield T., Muneeb F., Page O., Zeb E., Al-Azzawi A., McIntosh J., Vucicevic A., Hughes M., Brooks L., Fanibi B., Dixon M., Njoku P., Morris D., Jobson J., Chowdhury H., Alawode D. O. T., Wynell-Mayow W., Udayachandran V., Alsoof D., Ekert J., Joseph N., Zulkefley N., Hunt G., Christodoulou T., Wright O., Soman S., Jamal M., Beqiri S., Borgas P., Christie S., Pereira F., Browne S., Yiu J., Dworkin A., Brayley J., Palmer A., Charalambos M., Jones C. S., Toner S., Cowden R., Lee L., Nicol P., Holman O., Imtiaz M., Albert V., Leung S. P., Erotocritou M., Stroud R., Wilkin R., Thomson W., Mackee L., G N., Bei Y., Mckenna Favier S., Ibrahim A., Kler A., Reynolds L., Mohamed S. H., Majeed Y., Fakim B., Jones A., Liversedge G., Carrington Z., Windebank J., Izzarina A., Akbani U., Craven J., Aldarragi A., Harding S., Millward A., Bedford M., Gopalan V., Midgen A., Khadka P., Cheng O., Taneja S., Manobharath N., Kok J. Y., Lim D. W. E., Buick T., Boland M., Piya S., Devlin R., Fairfield C. J., George R. J., Rahi M., Zaman S., Hajiev S., Ross T., Crisp E., Thompson C., Charalambous A., Hollywood J. L., Hammond R. F. L., Matthews J., Mendonca V., Spinty J., Khan K., Cheng J., Glynn N., Muhammad U., Khan M., Anderson L., Mccormack K., Mak J., Patrawala S., Milinkovic N., Schofield R., Chauhan M., Hartley L., Hind J., Nelson L., Ratnasingham D., Whitehead T., Dimitriadis S., Marshall K., Flint E. J., Horner C., Heybourne A., Morgan H., Wickstone C., Panagiotou D., O'Connell E., Dean K., Iqbal R., Walsh L., Yu N., Rana N., Massie E., Ng J., Jung M., Lee Y. D., Harris M., White S., Boev B., Tonchev P., Prochazka V., Skalicky A., Ravn S., Ojakaar A., Dorr-Harim C., Koutserimpas C., Giraudo G., Armellini A., Ruzzenente A., Mazzeo C., De Padua C., Realis Luc A., Maroli A., Giani I., Cufari M. E., Vitali M., Gusai G. P., Quattromani R., Virgilio E., Berti S., Di Mola Ospedale SS Annunziata F. F., Papagni V., Tuminello F., Vittori L., Longheu A., Loche G. A., Braccio B., De Luca E., Resta G., Ancans G., Tamosiunas A., Petrulionis M., Andrejevic P., Stellingwerf M. E., Abdulrahman N., van de Pas K. G. H., Thomas G., Brandsma A. M., Davids J., Rottier S. J., de Roy van Zuidewijn D., Hawkins R., Ong H. I., Li Y., Desmond B., Winstanley J., Martins M., Americano M., Frade S., Senhorinho R., Peixoto R., Alves-Vale C., Lamas M., O'Connor D. B., Hoo M., Gopaul A., Scanlon K., O'Dwyer N., Jovanovic M., Panyko A., Van Vuuren S., Centeno A., Bernado I. R., Paniagua Garcia Senorans M., Gonzalez Amor L., Cuenca Ramirez A., Abrisqueta J., Estaire Gomez M., Arroyo A., Cerdan C., Gomez Romeu N., Enriquez-Navascues J. M., Collado-Roura F., Curchod P., Gaspar S., Imadalou L., Mutlu D., Akyol C., Uygur F. A., Eray I. C., Biyiklioglu O., Cetin M. F., Isik A. E., Karip B., Dogan H., Sarigul L., Tunc E., Aydin T., Bodur S., Karabulut K., Francis A. A., Al-hadithi A., To N., Lau I. S. F., Smith E., Mahapatra S., McAuliffe O., Imam L., Akram B., Hossaini S., Davies R., Ko M., Collins J., Pandya A., Reilly S., Archer J., Auty C., Roche C. D., Livie J., Chaudhry F. A., Ntakomyti E., Diallo R., Bylinski T., Wright J., Masiha E., Tung J., Shirazi B., Neilson A., Epton S., Patel N., Trussell S., Couldrey A., Donnelly C., and Eftychiou S. more...
- Abstract
Aim: Aspiration is a common cause of pneumonia in patients with postoperative ileus. Insertion of a nasogastric tube (NGT) is often performed, but this can be distressing. The aim of this study was to determine whether the timing of NGT insertion after surgery (before versus after vomiting) was associated with reduced rates of pneumonia in patients undergoing elective colorectal surgery. Method: This was a preplanned secondary analysis of a multicentre, prospective cohort study. Patients undergoing elective colorectal surgery between January 2018 and April 2018 were eligible. Those receiving a NGT were divided into three groups, based on the timing of the insertion: routine NGT (inserted at the time of surgery), prophylactic NGT (inserted after surgery but before vomiting) and reactive NGT (inserted after surgery and after vomiting). The primary outcome was the development of pneumonia within 30 days of surgery, which was compared between the prophylactic and reactive NGT groups using multivariable regression analysis. Results: A total of 4715 patients were included in the analysis and 1536 (32.6%) received a NGT. These were classified as routine in 926 (60.3%), reactive in 461 (30.0%) and prophylactic in 149 (9.7%). Two hundred patients (4.2%) developed pneumonia (no NGT 2.7%; routine NGT 5.2%; reactive NGT 10.6%; prophylactic NGT 11.4%). After adjustment for confounding factors, no significant difference in pneumonia rates was detected between the prophylactic and reactive NGT groups (odds ratio 1.03, 95% CI 0.56–1.87, P = 0.932). Conclusion: In patients who required the insertion of a NGT after surgery, prophylactic insertion was not associated with fewer cases of pneumonia within 30 days of surgery compared with reactive insertion. more...
- Published
- 2020
17. Safety and efficacy of non-steroidal anti-inflammatory drugs to reduce ileus after colorectal surgery
- Author
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G., Varghese S., Boyle E., Aljohmani L., Alexander J., Graziadei V., McCaughey C., Jain A., Ramanayake H., Sabnani R., Colon L. F., Bansal N., Stephens I., Tan R., Sharma S., Doherty G., Fenn S., Mulhare E., Walsh M., Leavey C., Costigan O., Griffin S., Dockry E., Khogali E., Aly A. K., McPhedran R., O'Gorman D., Vermeulen D., Dervan L., Kang S. J., Dixon O., Morrissey E., Compton M., Pentony A. R., Piong C. L., Nossier R., Hanna J., Sabir K., Eow S. Y., Ladak N., Boersma D., Kamath P. J., Soh T. B. W., Dyer A. H., Chee S. Y., Tan I. X. H., Kelliher A., Adeusi L., Howarth N., McCawley N., O'Neill A., Jones M. R., Saleh R., Singh A., Senaratne R., Kakodkar P., Subramanian I., Al-Salihi A., Vyas V., Vedadi A., Popescu S. S., Piras K., Ciubotaru C. I., Romanova E., Ponomarev N., Savchenko A., Luzan R., Lutovinova E., Gavrilina A., Barkovskaya A., Kudelkina N., Topchubaev D., Radulovic R., Milosevic K., Bojicic J., Gencic M., Jankovic U., Zubowicz M., Suchan P. 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E., Binbuga M., Kurklu O., Ceylan C., Yilmaz S., Calar S. N., Yildirim N., Yavuz G., Can B., Cesmeli E., Kus D., Kavar R. C., Cevlik A. D., Cengiz U., Turk E. G., Yilmaz I., Erdonmez H., Gursoy F., Kara H., Onsal U., Ozbek M., Kasar P. A., Ipor A., Ozen D., Olmez M., Altintas E., Toklu R., Saricicek T., Tipi O. U., Benli G. E., Tasdelen I., Tura A., Ucar A., Ekci B., Bilgili A. C., Kiraz I. N., Aksoy H., Basak A., Erdem M., Kayacan S., Sahin C., Uysal M., Karakus K., Altiner S., Demirci Z. S., Eren E., Yavas M., Aksoy A. B., Karagoz E., Sabanci R., Tumer S. S., Kargici K., Banaz T., Abdulrahman S. M. F., Yesilsancak M., Yanikoglu E., Karabulut A., Yilmaz D., Kuyumcu O. F., Kutluk F., Emiroglu B., Mollavelioglu B., Gereklioglu D., Guler M., Toprak S., Afsar H. B., Guler S. E., Alizade E., Alemdag G., Ulusahin M., Gul E. B., Yildirim R., Semiz A., Bektur G., Tomas K., Yarenci E., Demiroglu Y., Sunal A., Baykan B., Abbasguliyev H., Mutlu V., Mahmoudi Y., Dossa S. A. A., Mizan S. 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J., Livie V., Ibrahim B., Khalil M., Pooley G., Shishkin B., Docherty J., Southgate A., Coomes A., McGee F., Flanagan S., Tan Q. J., Anwar H., Clough R., Chrisp B., Cassels J., Cross G. W. V., Mercer L., Mercer C., Refalo A., Hadley R., McTighe A., Farrow F., Brodie A., Davis G., Shah D. R., Bowers C., Patel S., Morice O., Burzic A., Cheung J., Shashidhara A., Theodoraki G., Birk J., Ong A., Ng M. P. E., Wong R. T. W., Maese S., Yeap B., Iqbal Z., Rojoa D. M., Cabaleiro Barciela C., Ruddy C. M., Lindwe S., Qamar Y., Chuita S., Melaugh T., Hall J. D., Kouli O., Hassane A. S. I., Azhar A. W., Tan T. K., Perchard W., Scurr T., Campbell E., Kelk L., Ghosh A., Gibbins A., Mala D., Loizidou A., Hall O., Mecia L., Hew C., Varathan K., Tong L., Chandrasekar B., Buchanan E., O'Connell M., Kwak S. Y., Ong E. 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L., Sanders-Crook L., Bhatia S., Eames S., Lewis F., Kirupananthan P., Boh Z. Y., Dass S., Soma A., Newton A., Hill M., Shafiq Y., Brkljac M., Boyce L., English W. J., Lam S., Chipeta C., Jain C., Garofalidou T., Novotny S. A., Locke S., Bowman C., Begaj A., Murphy C., Radcliffe K., Chong J. T., Jeffrey E., Chaudhury N., Rajendran K., Akbar Z., Walters B., Kulendrarajah B., Tran N., Shrestha S., Parmar S., Gallagher C., Hennessy L., Pentti E., Badhrinarayanan S., Fung A., Mansoor M., Kenny R., Kan P., Lee D. E., Khosla S., Samake M., Shaban F., Aftab R., Gough M., Woodburn B., Vayalapra S., McMurrugh K., Jimulia D., Deol S., Pike S., Embury-Young Y., Patel M., Kilgallon E., Keating R., Walsh A., Khan H., Logue G., Orekoya M., Alasmar M., Charalambides M., Clave Llavall A., Williamson E., Bharwada Y., Zearmal S., Evans H., Panikkar M., de la Cruz G., Caplan J., Ruparelia A., Tanvir T., Soare C., Pang Y. L., Trotter J., Zaidi A., Thakrar V., Pulickal P., Ahmed H., Parnell J., Lennock S., Ford V., Brignall R., O'Neill D., Hanna R., Kane R., Nicola M., Rajput K., Xiao Y., Michael S., Wright E., Juniper S., Thompson E., Hoskyns L., Kanitkar A., Ross C., Unsworth A., Rshaidat H., Demarre K., Chiang A., Bareh A., van Dellen J., Faqihinejad C., Gadhvi A., Grant R., Lewsey J., Morris A., Martin H., McClarty C., Sanyal S., Alsaif A., Palkhi A., Bhopal S., Vishnu K S., Papanikolaou A., Mitra A., Nur A., Ali F., Burford C., Huq T., Irwin E., Matthews L., Ngu W. S., Hosfield T., Muneeb F., Page O., Zeb E., Al-Azzawi A., McIntosh J., Vucicevic A., Hughes M., Brooks L., Fanibi B., Dixon M., Njoku P., Morris D., Jobson J., Chowdhury H., Alawode D. O. T., Wynell-Mayow W., Udayachandran V., Alsoof D., Ekert J., Joseph N., Zulkefley N., Hunt G., Wright O., Soman S., Jamal M., Beqiri S., Borgas P., Christie S., Pereira F., Browne S., Yiu J., Dworkin A., Brayley J., Palmer A., Charalambos M., Jones C. J., Toner S., Cowden R., Lee L., Nicol P., Holman O., Imtiaz M., Albert V., Leung S. P., Erotocritou M., Stroud R., Wilkin R., Thomson W., Mackee L., G N., Bei Y., Mckenna Favier S., Ibrahim A., Kler A., Reynolds L., Mohamed S. H., Majeed Y., Fakim B., Jones A., Liversedge G., Carrington Z., Windebank J., Izzarina A., Akbani U., Craven J., Aldarragi A., Harding S., Millward A., Bedford M., Gopalan V., Midgen A., Khadka P., Cheng O., Taneja S., Manobharath N., Kok J. Y., Lim D. W. E., Buick T., Boland M., Piya S., Devlin R., Fairfield C. J., George R. J., Rahi M., Zaman S., Hajiev S., Ross T., Crisp E., Thompson C., Charalambous A., Hollywood J. L., Hammond R. F. L., Matthews J., Mendonca V., Spinty J., Khan K., Cheng J., Glynn N., Muhammad U., Khan M., Anderson L., Mccormack K., Mak J., Patrawala S., Milinkovic N., Schofield R., Chauhan M., Hartley L., Hind J., Nelson L., Ratnasingham D., Whitehead T., Dimitriadis S., Marshall K., Flint E. J., Horner C., Heybourne A., Morgan H., Wickstone C., Panagiotou D., O'Connell E., Dean K., Iqbal R., Walsh L., Yu N., Rana N., Massie E., Ng J., Jung M., Lee Y. D., Harris M., White S., Boev B., Tonchev P., Prochazka V., Skalicky A., Ravn S., Ojakaar A., Dorr-Harim C., Koutserimpas C., Giraudo G., Armellini A., Ruzzenente A., Mazzeo C., De Padua C., Realis Luc A., Maroli A., Giani I., Cufari M. E., Vitali M., Gusai G. P., Quattromani R., Virgilio E., Berti S., Di Mola F. F., Papagni V., Tuminello F., Vittori L., Longheu A., Loche G. A., Braccio B., De Luca E., Resta G., Ancans G., Tamosiunas A., Petrulionis M., Andrejevic P., Stellingwerf M. E., Abdulrahman N., van de Pas K. G. H., Thomas G., Brandsma A. M., Davids J., Rottier S. J., de Roy van Zuidewijn D., Hawkins R., Ong H. I., Li Y., Desmond B., Winstanley J., Martins M., Americano M., Frade S., Senhorinho R., Peixoto R., Alves-Vale C., Lamas M., O'Connor D. B., Hoo M., Gopaul A., Scanlon K., O'Dwyer N., Jovanovic M., Panyko A., Van Vuuren S., Curchod P., Gaspar S., Imadalou L., Mutlu D., Akyol C., Uygur F. A., Eray I. C., Biyiklioglu O., Cetin M. F., Isik A. E., Karip B., Dogan H., Sarigul L., Tunc E., Aydin T., Bodur S., Karabulut K., Al-hadithi A., To N., Lau I. S. F., Smith E., Mahapatra S., McAuliffe O., Imam L., Akram B., Hossaini S., Davies R., Ko M., Collins J., Pandya A., Reilly S., Archer J., Auty C., Roche C. D., Livie J., Chaudhry F. A., Ntakomyti E., Diallo R., Bylinski T., Wright J., Masiha E., Tung J., Shirazi B., Neilson A., Epton S., Patel N., Trussell S., Couldrey A., Donnelly C., Eftychiou S., Chapman, S, Clerc, D, Blanco-Colino, R, Otto, A, Nepogodiev, D, Pagano, G, Schaeff, V, Soares, A, Zaffaroni, G, Zebrak, R, Hodson, J, Glasbey, J, Pata, P, Pellino, G, Sgro, A, van Elst, T, Van Straten, S, Knowles, C, Borakati, A, Bath, M, Yasin, I, Mclean, K, Arthur, T, Kovacevic, M, Delibegovic, S, Karamanliev, M, Swamad, M, Paramasivam, R, Martensen, A, Larsen, H, Radeker, L, Frey, P, Kechagias, A, Venara, A, Duchalais, E, Ioannidis, A, Pata, F, Pasquali, S, Simioni, A, Farina, V, Podda, M, Lorenzon, L, Jakubauskas, M, Chu, M, Fagan, P, Wells, C, Alagoa Joao, A, Juloski, J, Ciubotaru, C, Popescu, S, Yanishev, A, Lee, S, Ozkan, B, Yagiz Sen, A, Aktas, M, Baki, B, Yuksek, B, Kamarajah, S, Khaw, R, Mills, E, Goodson, R, Thakral, N, Ablett, A, Adra, M, Kwek, I, Khan, S, Quinn, P, Manley, L, Badran, A, Ramjeeawon, A, 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R., Demirtas B., Cavus T., Yuksek A., Mazlum S. S., Yelkenci C., Baran T., Satilmisoglu M., Sahin A. Z., Kilinc A., Isik K., Yumurtaci O., Emin A., Girit C., Yildirak M. K., Senyigit E., Guldag A., Soyleyici B., Aytin Y. E., Akay F. E., Iskan N. G., Mutlu B., Sunay A. O., Tie-Gill T., Ramsay G., De Paola L., McGuckin S., Alshakhs A., Ahmeidat A., Goergen N., Ali Z., Mullarkey L., Walshe R., Lewis E., Berry B., Moneim J., Mookerjee S., Christy S., Ojofeitimi O., Carroll L., Hylands A., Delaugere L. P., Reveendran D., Coulter C., Ralston C., Laverty L., Gallagher P., Ahmed A., Yeo Y. Q., Elliott D., Bennett J., Mcnamara M., Sivarajah S., Dunmore C., Aitken G., Nair M., Aly M. H., Buari M., Ahmed K., Sheikh Z., Monks M., Lehmann J., Rotimi O., Bell T., Limnatitou D., Gormley S., Taleongpong P., Patel V., Macgregor L., Amini S., Turner C., Dwyer-Hemmings L., Busuttil A., Powell J., Hensher C., Vivian F., Wcislo K., Millar Z., Hirosue S., Ogunmwonyi I., Nakakande D., Gaze H., Nirmalanantha A., Bin Amran A. M., Foulkes A., Jones N., Pillai S., Khoury G., Powell T., Maleyko I., Sangheli A., Ransome M., Isse M., Aromolaran O., Bholah H., Anbarasan J., Rehman S., Hu E., Timms S., Reynolds W., Hotchkies A., Misra V., Theocharidou L., Malik T., Janmohamed I., Carhart B., Khan A., Hullait R., Rylance A., Butt S., Leathes J., Philip Rajathasan T., Jeddy H., Kyaw H. A., Wong N., Karelia S., Clements J. M., Rainey M., Joshi N., Rahman A., Gallagher M., Rebuffa N., Abdelgalil R., Siaw Yen Lai R., Laurence N., Thomas S., Green C., Frostick R., Khera R., Povey M., Wong H. L., McCusker C., Hlukha L., Pike G., Kamel F., Thakkar R., Donaldson C., Sequeira Campos M., Armitage M. N., Hussain A. S., Hardy B., Hassan Serry M. Y., Bradbury M., Osunronbi T., Tam L. Y. C., Khanan Kaabneh A., Lawther J., Fisher P., Tribedi T., Moosa A., Ramdin A., Goble M., Downs E., Wheldon L., Baggus E., Mandal A., Nayeem A., Ahmed S., Fradley W., Wilson C., Gallagher S., Criswell T., Ward J., Mukkavilli A., Stubbs B., Fordyce W., Suchdev N., Wei Lim S., Sookramanien S. R., Chan A., Bointas G., Paul M., Ward K. L., Bagnall M., Pherwani S. A., Wang K., Mitchell L., Heyworth J., Ayyar S., Polson R., Mackenzie E., Doyle N., Habib Z., Zardab M., Sartaj F., Farooq H., Tabibi M., Drury D. J., James S. J., Barnett R., Teasdale A. B., Richardson E. T. J., Thomas D. A., Williams R. L., Najabat-Lattif H. F., Cahya E., Lou G., Coyle M., Homyer K., Zhu L. Y., Woods M., Chang J., O'Callaghan H., Suchett-Kaye I., Mihailidis T. H., Alawattegama H., Seite E., Barrett A., Riordan E., Lam W., Dowdeswell M., Mulvenna C., Awokoya O., Gurowich L., Dhera K., Hayat S., Tincknell L., Spazzapan M., Teeling F., Sysum K., Latter J., Latter M., Khan S., Guruswamy M., Beedham W., Brazier E., Elghobashy M., Bajaj M., Mann H., Etel E., Woodmass M., Hayden H., Ali Y., Husain S., Arnold A., Pedersen A. C., Cunha P., Ahmed M., Al Zawawi S., Kudva V., Theodoropoulou K., Miscampbell M., Robinson A. V., Johnston J., Dharni A., Lamb S., Westerman T., Evans E., Campbell L., Gillespie M., Cheong C. M., Kulathevanayagam K., Varghese A., Ike S. I., Chu T. S. M., Baljer B., Mogg J. A. W., Rai P., Claireaux H. A., Williams M., Smillie R., Goetz J., Appleby E., Fadipe T., Vaughan-Burleigh S., Puri G., Hussain P., Flather R., Cutler A., Pathak S., Sheldon J., Collicott T., al-Ausi M., Jovaisaite A., Shah S. M., Khalid N., Gutmann D., Davison S., Alame Y. J., Syed L., Owen W. J., Ahsan S. D., Anthony-Uzoeto U., Macleod Hall C., Zheng S., Wynter K., James C., Sapre D., Ghosh R., Baird J., Cockburn L., Blackwood O., Simpson W., Jeong S., Bishop S., Bate R., Hobson C., Adam A. H., Redclift C., Do J., Adeleye O., Poli F., Batterham A., Brown S., Parekh J. N., Clay W., Pieri K., Jackson A., Saxena A., Gurung B., Oyebola T., O'Brien F., Djeugam B., Gardezi S., Ul-Hasan S., Martin-Hernandez M. P., Sisley M., Modi S., Antakia R., Elbayouk A., Soh Y. J., Mather J., Yusuf Z., Al-Sarraf Z., Naja M., Rassool S. B., Convill J., Nikookam Y., Warsame A., Pace C., Kiandee M., Ridwan R., Carey C., Hirri F., McMillan M. J. A., Ling J. J., Pendelbury L., Kerimzade K., Tang A., Howard E. O., Humayun S., Wadsworth O. J., Tan K., Abdelhameed F., Haglund C., Radnaeva I., Hu N., Rambhatla S., Waldron D., Madahar P., Malik S., Meney L. C., Ibrahim I., Kang C. K., Chiu J. Z. J., Livie V., Ibrahim B., Khalil M., Pooley G., Shishkin B., Docherty J., Southgate A., Coomes A., McGee F., Flanagan S., Tan Q. J., Anwar H., Clough R., Chrisp B., Cassels J., Cross G. W. V., Mercer L., Mercer C., Refalo A., Hadley R., McTighe A., Farrow F., Brodie A., Davis G., Shah D. R., Bowers C., Patel S., Morice O., Burzic A., Cheung J., Shashidhara A., Theodoraki G., Birk J., Ong A., Ng M. P. E., Wong R. T. W., Maese S., Yeap B., Iqbal Z., Rojoa D. M., Cabaleiro Barciela C., Ruddy C. M., Lindwe S., Qamar Y., Chuita S., Melaugh T., Hall J. D., Kouli O., Hassane A. S. I., Azhar A. W., Tan T. K., Perchard W., Scurr T., Campbell E., Kelk L., Ghosh A., Gibbins A., Mala D., Loizidou A., Hall O., Mecia L., Hew C., Varathan K., Tong L., Chandrasekar B., Buchanan E., O'Connell M., Kwak S. Y., Ong E. 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L., Sanders-Crook L., Bhatia S., Eames S., Lewis F., Kirupananthan P., Boh Z. Y., Dass S., Soma A., Newton A., Hill M., Shafiq Y., Brkljac M., Boyce L., English W. J., Lam S., Chipeta C., Jain C., Garofalidou T., Novotny S. A., Locke S., Bowman C., Begaj A., Murphy C., Radcliffe K., Chong J. T., Jeffrey E., Chaudhury N., Rajendran K., Akbar Z., Walters B., Kulendrarajah B., Tran N., Shrestha S., Parmar S., Gallagher C., Hennessy L., Pentti E., Badhrinarayanan S., Fung A., Mansoor M., Kenny R., Kan P., Lee D. E., Khosla S., Samake M., Shaban F., Aftab R., Gough M., Woodburn B., Vayalapra S., McMurrugh K., Jimulia D., Deol S., Pike S., Embury-Young Y., Patel M., Kilgallon E., Keating R., Walsh A., Khan H., Logue G., Orekoya M., Alasmar M., Charalambides M., Clave Llavall A., Williamson E., Bharwada Y., Zearmal S., Evans H., Panikkar M., de la Cruz G., Caplan J., Ruparelia A., Tanvir T., Soare C., Pang Y. L., Trotter J., Zaidi A., Thakrar V., Pulickal P., Ahmed H., Parnell J., Lennock S., Ford V., Brignall R., O'Neill D., Hanna R., Kane R., Nicola M., Rajput K., Xiao Y., Michael S., Wright E., Juniper S., Thompson E., Hoskyns L., Kanitkar A., Ross C., Unsworth A., Rshaidat H., Demarre K., Chiang A., Bareh A., van Dellen J., Faqihinejad C., Gadhvi A., Grant R., Lewsey J., Morris A., Martin H., McClarty C., Sanyal S., Alsaif A., Palkhi A., Bhopal S., Vishnu K S., Papanikolaou A., Mitra A., Nur A., Ali F., Burford C., Huq T., Irwin E., Matthews L., Ngu W. S., Hosfield T., Muneeb F., Page O., Zeb E., Al-Azzawi A., McIntosh J., Vucicevic A., Hughes M., Brooks L., Fanibi B., Dixon M., Njoku P., Morris D., Jobson J., Chowdhury H., Alawode D. O. T., Wynell-Mayow W., Udayachandran V., Alsoof D., Ekert J., Joseph N., Zulkefley N., Hunt G., Wright O., Soman S., Jamal M., Beqiri S., Borgas P., Christie S., Pereira F., Browne S., Yiu J., Dworkin A., Brayley J., Palmer A., Charalambos M., Jones C. 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J., Horner C., Heybourne A., Morgan H., Wickstone C., Panagiotou D., O'Connell E., Dean K., Iqbal R., Walsh L., Yu N., Rana N., Massie E., Ng J., Jung M., Lee Y. D., Harris M., White S., Boev B., Tonchev P., Prochazka V., Skalicky A., Ravn S., Ojakaar A., Dorr-Harim C., Koutserimpas C., Giraudo G., Armellini A., Ruzzenente A., Mazzeo C., De Padua C., Realis Luc A., Maroli A., Giani I., Cufari M. E., Vitali M., Gusai G. P., Quattromani R., Virgilio E., Berti S., Di Mola F. F., Papagni V., Tuminello F., Vittori L., Longheu A., Loche G. A., Braccio B., De Luca E., Resta G., Ancans G., Tamosiunas A., Petrulionis M., Andrejevic P., Stellingwerf M. E., Abdulrahman N., van de Pas K. G. H., Thomas G., Brandsma A. M., Davids J., Rottier S. J., de Roy van Zuidewijn D., Hawkins R., Ong H. I., Li Y., Desmond B., Winstanley J., Martins M., Americano M., Frade S., Senhorinho R., Peixoto R., Alves-Vale C., Lamas M., O'Connor D. B., Hoo M., Gopaul A., Scanlon K., O'Dwyer N., Jovanovic M., Panyko A., Van Vuuren S., Curchod P., Gaspar S., Imadalou L., Mutlu D., Akyol C., Uygur F. A., Eray I. C., Biyiklioglu O., Cetin M. F., Isik A. E., Karip B., Dogan H., Sarigul L., Tunc E., Aydin T., Bodur S., Karabulut K., Al-hadithi A., To N., Lau I. S. F., Smith E., Mahapatra S., McAuliffe O., Imam L., Akram B., Hossaini S., Davies R., Ko M., Collins J., Pandya A., Reilly S., Archer J., Auty C., Roche C. D., Livie J., Chaudhry F. A., Ntakomyti E., Diallo R., Bylinski T., Wright J., Masiha E., Tung J., Shirazi B., Neilson A., Epton S., Patel N., Trussell S., Couldrey A., Donnelly C., and Eftychiou S. more...
- Abstract
Background: Ileus is common after elective colorectal surgery, and is associated with increased adverse events and prolonged hospital stay. The aim was to assess the role of non-steroidal anti-inflammatory drugs (NSAIDs) for reducing ileus after surgery. Methods: A prospective multicentre cohort study was delivered by an international, student- and trainee-led collaborative group. Adult patients undergoing elective colorectal resection between January and April 2018 were included. The primary outcome was time to gastrointestinal recovery, measured using a composite measure of bowel function and tolerance to oral intake. The impact of NSAIDs was explored using Cox regression analyses, including the results of a centre-specific survey of compliance to enhanced recovery principles. Secondary safety outcomes included anastomotic leak rate and acute kidney injury. Results: A total of 4164 patients were included, with a median age of 68 (i.q.r. 57–75) years (54·9 per cent men). Some 1153 (27·7 per cent) received NSAIDs on postoperative days 1–3, of whom 1061 (92·0 per cent) received non-selective cyclo-oxygenase inhibitors. After adjustment for baseline differences, the mean time to gastrointestinal recovery did not differ significantly between patients who received NSAIDs and those who did not (4·6 versus 4·8 days; hazard ratio 1·04, 95 per cent c.i. 0·96 to 1·12; P = 0·360). There were no significant differences in anastomotic leak rate (5·4 versus 4·6 per cent; P = 0·349) or acute kidney injury (14·3 versus 13·8 per cent; P = 0·666) between the groups. Significantly fewer patients receiving NSAIDs required strong opioid analgesia (35·3 versus 56·7 per cent; P < 0·001). Conclusion: NSAIDs did not reduce the time for gastrointestinal recovery after colorectal surgery, but they were safe and associated with reduced postoperative opioid requirement. more...
- Published
- 2020
18. Safety of hospital discharge before return of bowel function after elective colorectal surgery
- Author
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J Chapman, S, Blanco-Colino, R, Pérez-Ajates, S, O Anabitarte Bautista, Hodson, J, C Glasbey, J, Pata, F, Pellino, G, Sgrò, A, Soares, A, T van Elst, S Van Straten, Nepogodiev, D, Borakati, A, F Bath, M, H Yasin, I, Mclean, K, Arthur, T, Kovacevic, M, Delibegovic, S, Karamanliev, M, Swamad, M, Žebrák, R, Paramasivam, R, Martensen, A, M Larsen, H, Rädeker, L, E Frey, P, Kechagias, A, Venara, A, Duchalais, E, Ioannidis, A, Pasquali, S, Simioni, A, Farina, V, Podda, M, Lorenzon, L, Schaeff, V, Otto, A, Jakubauskas, M, R van Elst, T, Chu, M, Pvb, Fagan, I Wells, C, A Alagoa João, Juloski, J, Y El Kasmy El Kasmi, Espin-Basany, E, Clerc, D, Ciubotaru, C, Popescu, S, Yanishev, A, Lee, S, B Ozkan, B, A Yagız Sen, K Aktas, M, E Baki, B, Yüksek, B, Kamarajah, S, A Khaw, R, Mills, E, Goodson, R, Thakral, N, D Ablett, A, Adra, M, Kwek, I, M Khan, S, Quinn, P, R Manley, L, Badran, A, Ramjeeawon, A, Campbell, A, L Tan, H, S Rye, D, Rajaraman, N, G Norman, J, Vutipongsatorn, K, Solomou, G, Akhbari, 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Kenny R., Kan P., Lee D.E., Khosla S., Samake M., Shaban F., Aftab R., Gough M., Woodburn B., Vayalapra S., McMurrugh K., Jimulia D., Deol S., Pike S., Embury-Young Y., Patel M., Kilgallon E., Keating R., Walsh A., Khan H., Logue G., Orekoya M., Alasmar M., Charalambides M., Llavall A.C., Williamson E., Bharwada Y., Zearmal S., Evans H., Panikkar M., de la Cruz G., Caplan J., Ruparelia A., Tanvir T., Soare C., Pang Y.L., Trotter J., Zaidi A., Thakrar V., Pulickal P., Ahmed H., Parnell J., Lennock S., Ford V., Brignall R., O'Neill D., Hanna R., Kane R., Nicola M., Rajput K., Xiao Y., Michael S., Wright E., Juniper S., Thompson E., Hoskyns L., Kanitkar A., Ross C., Unsworth A., Rshaidat H., Demarre K., Chiang A., Bareh A., van Dellen J., Faqihinejad C., Gadhvi A., Grant R., Lewsey J., Morris A., Martin H., McClarty C., Sanyal S., Alsaif A., Palkhi A., Bhopal S., Burford C., Huq T., Irwin E., Matthews L., Ngu W.S., Hosfield T., Muneeb F., Page O., Zeb E., Al-Azzawi A., McIntosh J., Vucicevic A., Hughes M., Brooks L., Fanibi B., Dixon M., Njoku P., Morris D., Jobson J., Chowdhury H., Joseph N., Zulkefley N., Hunt G., Christodoulou T., Wright O., Soman S., Jamal M., Beqiri S., Borgas P., Christie S., Pereira F., Browne S., Yiu J., Dworkin A., Brayley J., Palmer A., Charalambos M., Jones C.S., Toner S., Cowden R., Lee L., Nicol P., Holman O., Imtiaz M., Albert V., Leung S.P., Erotocritou M., Stroud R., Wilkin R., Thomson W., Mackee L., Kler A., Reynolds L., Mohamed S.H., Majeed Y., Fakim B., Jones A., Liversedge G., Carrington Z., Windebank J., Izzarina A., Akbani U., Craven J., Aldarragi A., Harding S., Millward A., Bedford M., Gopalan V., Midgen A., Khadka P., Cheng O., Taneja S., Manobharath N., Kok J.Y., Lim D.W.E., Buick T., Boland M., Piya S., Devlin R., Fairfield C.J., George R.J., Rahi M., Zaman S., Hajiev S., Ross T., Crisp E., Thompson C., Charalambous A., Hollywood J.L., Hammond R.F.L., Matthews J., Mendonca V., Spinty J., Khan K., Cheng J., Glynn N., 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M., Frade S., Senhorinho R., Peixoto R., Alves-Vale C., Lamas M., O'Connor D.B., Hoo M., Gopaul A., Scanlon K., O'Dwyer N., Jovanovic M., Panyko A., Van Vuuren S., Centeno A., Bernado I.R., Senorans M.P.G., Amor L.G., Ramirez A.C., Abrisqueta J., Gomez M.E., Arroyo A., Cerdan C., Romeu N.G., Enriquez-Navascues J.M., Collado-Roura F., Curchod P., Gaspar S., Imadalou L., Mutlu D., Akyol C., Uygur F.A., Eray I.C., Biyiklioglu O., Cetin M.F., Isik A.E., Karip B., Dogan H., Sarigul L., Tunc E., Aydin T., Bodur S., Karabulut K., Francis A.A., Al-hadithi A., Lau I.S.F., Smith E., Mahapatra S., McAuliffe O., Imam L., Akram B., Hossaini S., Davies R., Ko M., Collins J., Pandya A., Reilly S., Archer J., Livie J., Chaudhry F.A., Ntakomyti E., Diallo R., Bylinski T., Wright J., Masiha E., Tung J., Shirazi B., Neilson A., Epton S., Patel N., Trussell S., Couldrey A., Donnelly C., Eftychiou S., Salman M., Skejo, Licari L., Men, Chapman, S. 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Z., Abdulrahman, Z., Pruijssers, S. R., Geneta, V. P., Chu, M., Wilton, S., Kandelaki, H., Peng, S. L., Campbell, S., Lim, Y. K., Yassaie, S. S., Murray, M., Haran, C., Tan, J., Castro, J., Laranjeira, A., Catarino, S., Neves-Marques, C., Correia, J. G., Vieira, B. N., Quintela, A. C., Serra, M. L., Maciel, J., Cunha, M., Aparicio, D. J., Neves, J., Azevedo, J., Romano, M., Eiro, F., Romano, J., Monteiro, C., Claro, M., Capote, H., Ferreira, M., Sousa, X., Peyroteo, M., Machado, N. D., Guerreiro, I., Costa, M., Rosete, M., Salman, M., English, C., Mohammed, N., Litvin, A., Cuk, V. V., Meszarosova, K., Jaich, R., De Lima, H., Brooks, S., Marx, M., Salvation, M. N., Cardo, J. G., Mora-Guzman, I., Muriel, J. S., de Andres Olabarria, U., Muriel, P., Vinas, C. J., Alconchel, F., Sinovas, O. E., Oro, C. F., Otero, M. L., Jimenez, S. F., Bellmunt, O. C., Caballero, J. M., Rubio-Perez, I., Aguilar-Martinez, M. M., Segura-Sampedro, J. J., Moreno, C. O., Parra, D. N., Diz, A. M. 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M., Griffiths, N., Ganesananthan, S., Jasionowska, S., Poustie, M., Wong, C., Turner, T., Pyc, W., Sloper, W., Warner, C., Coey, J., Mason, D., Sait, S., Kowal, M., Owen, M., Saiyed, A., Ashworth, I., Akbari, K., Curran, M., Martin, P., Parker, D., Kwok, K., Lye, C., Ghaly, M., Sammour, T., Lewis, D., Mundasad, R., Wilkes, A., Ctercteko, G., Maslyankov, S., Dimov, R., Iliev, S., Dimitrov, D., Marek, F., Orhalmi, J., Skalicky, P., Skalicky, T., Chrz, K., Christensen, P., Worsoe, J., Kristensen, E. S., Emmertsen, K. J., Loeve, U. S., Mihaljevic, A. L., Herrle, F., Konstantinidis, K. M., Korkolis, D., Karanikas, I., Vincenti, L., Anania, G., Borghi, F., Agresta, F., Maretto, I., Parisi, A., Bucci, L., De Palma, G., Guglielmi, A., Cucinotta, E., La Torre, F., Cianchi, F., Guerrieri, M., Trompetto, M., Persiani, R., Micheletto, G., Delrio, P., Cantafio, S., Ronconi, M., Bisagni, P. A. 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G., Hubner, M., Petermann, D., Sauvain, M. O., Ozben, V., Gecim, I. E., Disci, E., Rencuzogullari, A., Kurt, A., Bisgin, T., Pehlivan, M., Isik, A., Onur, E., Leventoglu, S., Keskin, M., Guner, A., Sahin, S. T., Ozbalci, G. S., Pergel, A., Albayrak, D., Bruce, D., Fearnhead, N., Arthur, J., Harron, M., Beattie, G., Titu, L., Saunders, M., Phillips, J., Dindyal, S., Cresswell, B., Gercek, Y., Lee, J., Linn, T., Faulkner, G., Lockwood, S., Rees, J., Charalabopoulos, A., Campbell, B., Kontovounisios, C., Amarnath, T., Johnson, M., Epanomeritakis, E., Vigs, S., Nastro, P., Gilliam, A., Smolarek, S., Wilson, T., Orbell, J., Mcintyre, R., Agarwal, T., Hainsworth, P., Patel, P., Vijay, J., Liu, B., Rao, P. D., Roxburgh, C., Vipond, M., Youssef, H., Thorn, C., Schizas, A., Denley, S., Bowley, D., Das, K., Cuming, T., Saha, A., Chung, L., Pitt, J., Davis, P., Jones, O., Taylor, M., Bhargava, A., Haji, A., Watson, N., Bloom, I., Singh, B., Norwood, M., Gurjar, S., Stylianides, N., Mirza, S., Evans, M., Williams, G., Patil, P., Hernon, J., Finch, G., Green, S., Chapple, K., Fafemi, O., Warusavitarne, J., Samee, A., Carden, C., Ong, L., Verma, K., Joseph, A., Rawat, N., Pinkney, T., Oke, O., Glen, P., Maxwell-Armstrong, C., Oliphant, R., Garner, J., Moug, S. J., Middleton, S., Lund, J. N., Smart, N. J., Osborn, G., Moore, T., Raymond, T., Knowles, C. H., Hany, T. S., Clarke, R., Khera, G., Brady, R., Sellahewa, C., Mason, C., Torrance, A., Lasithiotakis, K., Knight, J., Pullybank, A., Ainsworth, P., Reid, F., Ramwell, A., Maslekar, S., George, R., Skull, A., Holtham, S., Muhammad, K., Lal, R., Varcada, M., Smith, F. M., Howlader, M., Defriend, D., Kirk, S., Richards, T., Evans, C., Borg, C. 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W., Gabbas, G., Marziali, I., Mazzocato, S., Vergari, R., Piazzai, F., Kubolli, I., Aggiusti, A., Paolucci, A., Ortenzi, M., Olivieri, M., Belluco, C., Antona, A. D., Basso, S., Morino, M., Mistrangelo, M., Clerico, G., De Santi, G., Bitonti, M. F., Frattalone, M., Fico, V., Santullo, F., Belia, F., Spinelli, A., Marco, M., Bevilacqua, M., Tringali, D., Bevilacqua, E., Panizzo, V., La Manna, V., Migliore, G., Aversano, A., Bucci, A. F., Marino, F., Carbone, F., Incollingo, P., Romano, F. M., Zalla, T., Baraghini, M., Romoli, L., Calussi, M., Vellei, S., Genzano, C., Feroci, F., Vita, M., Barberis, A., Serra, D., Grassia, M., Romelli, M., Ruggiero, S., Percassi, A., Piccinini, A. 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X., Peckham, H., Yeoh, T., Yong, S. Q., Chen, J. Y., Siva, S., Sam, Z. H., Gilani, M., Goh, Y. N., Muthukumar, M. G., Phillips, S., Tjoakarfa, J., Giri, A., Suresan, S., Thomas, P., Johnson, T. A., Williams, R. I., Rashid, A., Kushairi, A., Rais, A., James, A., Bugelli, M., Chechelnitskaya, Y., Sandhu, N., Tandon, R., Gray, M., Kumar, A., Ciurleo, C., Nyamali, I., Hiremath, S., Sinha, S., Chowdhary, M., Bradley, E., Mctiernan, M., Macdonald, S., Sharkey, S., Mclaughlin, N., Amey, C., Kraria, L., Skan, O., Kind, C., Tupper, P., Van Rhee, C., Honeyman, S. I., Menon, G., Jegatheeswaran, L., Madhavan, A., Warne, M., Malcolm, F. L., Lessware, T., Wilkerson, H. T., Chatterjee-Woolman, S., Yoong, A., Ahmed, W. U. R., Longshaw, A., Flannery, O., Green, R., Leaning, M., Cragg, J., Sharriff, H., Doherty, C., Kwan, K. W. L., Sanders-Crook, L., Bhatia, S., Eames, S., Lewis, F., Kirupananthan, P., Boh, Z. Y., Dass, S., Soma, A., Newton, A., Hill, M., Shafiq, Y., Brkljac, M., Boyce, L., English, W. J., Lam, S., Chipeta, C., Jain, C., Garofalidou, T., Novotny, S. A., Locke, S., Bowman, C., Begaj, A., Murphy, C., Radcliffe, K., Chong, J. T., Jeffrey, E., Chaudhury, N., Rajendran, K., Akbar, Z., Walters, B., Kulendrarajah, B., Tran, N., Shrestha, S., Parmar, S., Gallagher, C., Hennessy, L., Pentti, E., Badhrinarayanan, S., Fung, A., Mansoor, M., Kenny, R., Kan, P., Lee, D. E., Khosla, S., Samake, M., Shaban, F., Aftab, R., Gough, M., Woodburn, B., Vayalapra, S., Mcmurrugh, K., Jimulia, D., Deol, S., Pike, S., Embury-Young, Y., Patel, M., Kilgallon, E., Keating, R., Walsh, A., Khan, H., Logue, G., Orekoya, M., Alasmar, M., Charalambides, M., Llavall, A. C., Williamson, E., Bharwada, Y., Zearmal, S., Evans, H., Panikkar, M., de la Cruz, G., Caplan, J., Ruparelia, A., Tanvir, T., Soare, C., Pang, Y. L., Trotter, J., Zaidi, A., Thakrar, V., Pulickal, P., Ahmed, H., Parnell, J., Lennock, S., Ford, V., Brignall, R., O'Neill, D., Hanna, R., Kane, R., Nicola, M., Rajput, K., Xiao, Y., Michael, S., Wright, E., Juniper, S., Thompson, E., Hoskyns, L., Kanitkar, A., Ross, C., Unsworth, A., Rshaidat, H., Demarre, K., Chiang, A., Bareh, A., van Dellen, J., Faqihinejad, C., Gadhvi, A., Grant, R., Lewsey, J., Morris, A., Martin, H., Mcclarty, C., Sanyal, S., Alsaif, A., Palkhi, A., Bhopal, S., Burford, C., Huq, T., Irwin, E., Matthews, L., Ngu, W. S., Hosfield, T., Muneeb, F., Page, O., Zeb, E., Al-Azzawi, A., Mcintosh, J., Vucicevic, A., Hughes, M., Brooks, L., Fanibi, B., Dixon, M., Njoku, P., Morris, D., Jobson, J., Chowdhury, H., Joseph, N., Zulkefley, N., Hunt, G., Christodoulou, T., Wright, O., Soman, S., Jamal, M., Beqiri, S., Borgas, P., Christie, S., Pereira, F., Browne, S., Yiu, J., Dworkin, A., Brayley, J., Palmer, A., Charalambos, M., Jones, C. S., Toner, S., Cowden, R., Lee, L., Nicol, P., Holman, O., Imtiaz, M., Albert, V., Leung, S. P., Erotocritou, M., Stroud, R., Wilkin, R., Thomson, W., Mackee, L., Kler, A., Reynolds, L., Mohamed, S. H., Majeed, Y., Fakim, B., Jones, A., Liversedge, G., Carrington, Z., Windebank, J., Izzarina, A., Akbani, U., Craven, J., Aldarragi, A., Harding, S., Millward, A., Bedford, M., Gopalan, V., Midgen, A., Khadka, P., Cheng, O., Taneja, S., Manobharath, N., Kok, J. Y., Lim, D. W. E., Buick, T., Boland, M., Piya, S., Devlin, R., Fairfield, C. J., George, R. J., Rahi, M., Zaman, S., Hajiev, S., Ross, T., Crisp, E., Thompson, C., Charalambous, A., Hollywood, J. L., Hammond, R. F. L., Matthews, J., Mendonca, V., Spinty, J., Khan, K., Cheng, J., Glynn, N., Muhammad, U., Khan, M., Anderson, L., Mccormack, K., Mak, J., Patrawala, S., Milinkovic, N., Schofield, R., Chauhan, M., Hartley, L., Hind, J., Nelson, L., Ratnasingham, D., Whitehead, T., Dimitriadis, S., Marshall, K., Flint, E. J., Horner, C., Heybourne, A., Morgan, H., Wickstone, C., Panagiotou, D., O'Connell, E., Dean, K., Iqbal, R., Walsh, L., Yu, N., Rana, N., Massie, E., Ng, J., Jung, M., Lee, Y. D., Harris, M., White, S., Boev, B., Tonchev, P., Prochazka, V., Risko, J., Skalicky, A., Ravn, S., Ojakaar, A., Dorr-Harim, C., Koutserimpas, C., Giraudo, G., Armellini, A., Ruzzenente, A., Mazzeo, C., De Padua, C., Luc, A. R., Maroli, A., Vitali, M., Gusai, G. P., Quattromani, R., Virgilio, E., Berti, S., Di Mola, F. F., Papagni, V., Tuminello, F., Vittori, L., Longheu, A., Loche, G. A., Braccio, B., De Luca, E., Resta, G., Ancans, G., Tamosiunas, A., Petrulionis, M., Abdulrahman, N., van de Pas, K. G. H., Thomas, G., Brandsma, A. M., Davids, J., Rottier, S. J., de Roy van Zuidewijn, D., Hawkins, R., Ong, H. I., Li, Y., Desmond, B., Winstanley, J., Martins, M., Americano, M., Frade, S., Senhorinho, R., Peixoto, R., Alves-Vale, C., Lamas, M., O'Connor, D. B., Hoo, M., Gopaul, A., Scanlon, K., O'Dwyer, N., Jovanovic, M., Panyko, A., Van Vuuren, S., Centeno, A., Bernado, I. R., Senorans, M. P. G., Amor, L. G., Ramirez, A. C., Abrisqueta, J., Gomez, M. E., Arroyo, A., Cerdan, C., Romeu, N. G., Enriquez-Navascues, J. M., Collado-Roura, F., Curchod, P., Gaspar, S., Imadalou, L., Mutlu, D., Akyol, C., Uygur, F. A., Eray, I. C., Biyiklioglu, O., Cetin, M. F., Isik, A. E., Karip, B., Dogan, H., Sarigul, L., Tunc, E., Aydin, T., Bodur, S., Karabulut, K., Francis, A. A., Al-hadithi, A., Lau, I. S. F., Smith, E., Mahapatra, S., Mcauliffe, O., Imam, L., Akram, B., Hossaini, S., Davies, R., Ko, M., Collins, J., Pandya, A., Reilly, S., Archer, J., Livie, J., Chaudhry, F. A., Ntakomyti, E., Diallo, R., Bylinski, T., Wright, J., Masiha, E., Tung, J., Shirazi, B., Neilson, A., Epton, S., Patel, N., Trussell, S., Couldrey, A., and Donnelly, C. more...
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operative ,Male ,postoperative discharge ,Postoperative Complications ,0302 clinical medicine ,Colostomy ,CRITERIA ,Prospective Studies ,Bowel function ,Colectomy ,IMAGINE ,stoma ,intestines ,Proctectomy ,Ileostomy ,digestive, oral, and skin physiology ,patient discharge ,colorectal surgery, hospital discharge, bowel function ,RECOVERY ,Middle Aged ,adult ,colostomy ,elective surgical procedures ,female ,follow-up studies ,humans ,ileostomy ,ileus ,male ,middle aged ,multivariate analysis ,patient readmission ,patient safety ,postoperative complications ,prospective studies ,recovery of function ,colectomy ,proctectomy ,Patient Discharge ,Colorectal surgery ,ileus - - discharge - bowel function - elective - colorectal surgery ,Elective Surgical Procedures ,030220 oncology & carcinogenesis ,Female ,030211 gastroenterology & hepatology ,Patient Safety ,Cohort study ,safety ,Adult ,medicine.medical_specialty ,Ileus ,Patient Readmission ,defecation ,03 medical and health sciences ,medicine ,Hospital discharge ,Humans ,colorectal surgery ,colorectal resection ,Colorectal resection ,defecation, postoperative complications, colorectal surgery, intestines, patient discharge, patient readmission, safety, surgical procedures, operative, colorectal resection, ileus ,business.industry ,Recovery of Function ,Odds ratio ,medicine.disease ,digestive system diseases ,surgical procedures ,Surgery ,Multivariate Analysis ,Defecation ,business ,Follow-Up Studies - Abstract
Ileus is common after colorectal surgery and is associated with an increased risk of postoperative complications. Identifying features of normal bowel recovery and the appropriateness for hospital discharge is challenging. This study explored the safety of hospital discharge before the return of bowel function.A prospective, multicentre cohort study was undertaken across an international collaborative network. Adult patients undergoing elective colorectal resection between January and April 2018 were included. The main outcome of interest was readmission to hospital within 30 days of surgery. The impact of discharge timing according to the return of bowel function was explored using multivariable regression analysis. Other outcomes were postoperative complications within 30 days of surgery, measured using the Clavien-Dindo classification system.A total of 3288 patients were included in the analysis, of whom 301 (9·2 per cent) were discharged before the return of bowel function. The median duration of hospital stay for patients discharged before and after return of bowel function was 5 (i.q.r. 4-7) and 7 (6-8) days respectively (P 0·001). There were no significant differences in rates of readmission between these groups (6·6 versus 8·0 per cent; P = 0·499), and this remained the case after multivariable adjustment for baseline differences (odds ratio 0·90, 95 per cent c.i. 0·55 to 1·46; P = 0·659). Rates of postoperative complications were also similar in those discharged before versus after return of bowel function (minor: 34·7 versus 39·5 per cent; major 3·3 versus 3·4 per cent; P = 0·110).Discharge before return of bowel function after elective colorectal surgery appears to be safe in appropriately selected patients.El íleo es frecuente tras la cirugía colorrectal y se asocia con un aumento del riesgo de las complicaciones postoperatorias. Identificar las características de una recuperación normal del tránsito y la idoneidad para el alta hospitalaria es una tarea difícil. Este estudio examinó la seguridad del alta hospitalaria antes del restablecimiento de la función intestinal. MÉTODOS: Se llevó a cabo un estudio de cohortes prospectivo y multicéntrico a través de una red de colaboración internacional. Se incluyeron pacientes adultos sometidos a resección electiva colorrectal entre enero y abril 2018. El objetivo principal fue el reingreso hospitalario durante los 30 primeros días tras la intervención. Se utilizó un análisis de regresión multivariable para evaluar el impacto del momento del alta en función del restablecimiento de la función intestinal. El objetivo secundario fue las complicaciones postoperatorias en los primeros 30 días después de la cirugía, valoradas mediante el sistema de clasificación de Clavien-Dindo.Se incluyeron en el análisis 3.288 pacientes, de los cuales 301 (9,2%) fueron dados de alta antes del restablecimiento de la función intestinal. La mediana de la estancia hospitalaria de los pacientes dados de alta antes y después del restablecimiento de la función intestinal fue 5 (rango intercuartílico: 4-7) y 7 (6-8) días, respectivamente (P 0,001). No hubo diferencias significativas en las tasas de reingreso entre estos grupos (6,6% versus 8,0%; P = 0,499), y este resultado se mantuvo en el análisis multivariable tras el ajuste por diferencias basales (razón de opotunidades, odds ratio, OR 0,90; i.c. del 95% 0,55-1,46, P = 0,659). Las tasas de complicaciones postoperarorias fueron similares en aquellos dados de alta antes o después del restablecimiento de la función intestinal (complicaciones menores: 34,7% versus 39,5%; complicaciones mayores 3,3% versus 3,4%; P = 0,110). CONCLUSIÓN: Dar de alta antes del restablecimiento de la función intestinal tras cirugía colorrectal electiva parece ser seguro en pacientes debidamente seleccionados. more...
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- 2020
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19. Timing of nasogastric tube insertion and the risk of postoperative pneumonia: an international, prospective cohort study
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Glasbey J. C., Bibi S., Pata F., Ozkan B. B., Van Straten S., Hodson J., Chapman S. J., Blanco-Colino R., Pellino G., Sgro A., Soares A., van Elst T., Nepogodiev D., Borakati A., Bath M. F., Yasin I. H., Mclean K., Arthur T., Kovacevic M., Delibegovic S., Karamanliev M., Swamad M., Zebrak R., Paramasivam R., Martensen A., Larsen H. M., Radeker L., Frey P. E., Kechagias A., Venara A., Duchalais E., Ioannidis A., Pasquali S., Simioni A., Farina V., Podda M., Lorenzon L., ItSURG I., Schaeff V., Otto A., Jakubauskas M., van Elst T. R., Chu M., Fagan P. V. B., Wells C. I., Alagoa Joao A., Juloski J., Perez-Ajates S., Anabitarte Bautista O., El Kasmy Y., Espin-Basany E., Clerc D., Ciubotaru C., Popescu S., Yanishev A., Lee S., Yagiz Sen A., Aktas M. K., Baki B. E., Yuksek B., Kamarajah S., Khaw R. A., Mills E., Goodson R., Thakral N., Collaborative S., Ablett A. D., Adra M., Kwek I., Khan S. M., Quinn P., Manley L. R., Badran A., Ramjeeawon A., Campbell A., Tan H. L., Rye D. S., Rajaraman N., Norman J. G., Vutipongsatorn K., Solomou G., Akhbari M., Ali A., Murray V., Baker D. M., Brandao B. D., Stainer B., Thavayogan R., Jones D., Onafowokan O. O., Gharooni A., Dabab N., Carlton-Carew S., Kungwengwe G., Gabriel M., Sewart E., Shortland T. C., Lawday S., Pockney P., Dawson A., Brumfitt C. D., Stewart P., Ng B., Luong J. K., Ivanov V., Borisova A., Neykov V., Kuncarova K., Kolosova B., Antonova T., Farkasova M., Harbjerg J. L., Brandsborg S., Brinck S., Kjaer M. D., Mark-Christensen A., Unbehaun K. P., Dalsgaard P., Lycke K. D., LeNaoures P., Brigand C., Dumange E., Gout M., Moehwald C., Prem M., Alhalabi O., Sliwinski S., Krupp J., Gablenz E., Schmitzer L., Kopp A., Steinle J., Gsenger J., Pohl L. J., Riccardi M., Christodoulou I. M., Konstantinidis M., Machairas N., Zoikas A., Balalis D., Manatakis D. K., Aguilera M. L., Marano L., Fleres F., Lovisetto F., Sasia D., Segalini E., Pata G., Lucchi A., Sagnotta A., Campagnaro T., Petrelli F., Gallo G., Papandrea M., Testa V., Sinibaldi G., Di Candido F., Colombo F., Perrone G., Biancafarina A., Canonico G., Pagnanelli M., Curletti G., Bini R., de Manzoni Garberini A., Impellizzeri H., Cillara N., Tutino R., Picciariello A., Coletta D., Savino G., Ferrara F., Tamini N., Talamo G., Parini D., Giamundo P., lo Conte A., Pagano G., Ripetti V., Pesce A., Menduni N., Giudicissi R., Goldin E., Rega D., Belli A., Andriola V., Gordini L., Foppa C., Piccolo G., Birindelli A., Ferrari C., Ballarini Z., Tirelli F., Milone M., De Rosa M., Pipitone Federico N. S., Molteni B., Tilocca P. L., Sancini G., Piozzi G. N., Lauretta A., Poillucci G., Mulas S., Simcikas D., Portelli L., van Wijnbergen J. W. M., Dinger T. L., ten Doesschate S. F. H., van Dalen A. S. H. M., van den Bos D. D., Hansmann M., Medina Feliz J., Kuiper S. Z., Abdulrahman Z., Pruijssers S. R., Farik S., Elliott B. M., Geneta V. P., Wilton S., Kandelaki H., Peng S. L., Campbell S., Lim Y. K., Yassaie S. S., Murray M., Haran C., Tan J., Castro J., Laranjeira A., Catarino S., Neves-Marques C., Correia J. G., Vieira B. N., Quintela A. C., Serra M. L., Maciel J., Cunha M., Aparicio D. J., Neves J., Azevedo J., Romano M., Eiro F., Romano J., Monteiro C., Claro M., Almeida M. R., Peyroteo M., Machado N. D., Capote H., Ferreira M., Sousa X., Devesa H., Cavadas D., Guerreiro I., Costa M., Rosete M., Salman M., English C., Mohammed N., Litvin A., Cuk V. V., Meszarosova K., Jaich R., De Lima H., Brooks S., Marx M., Nshalati Salvation M., Garcia Cardo J., Mora-Guzman I., Sancho Muriel J., de Andres Olabarria U., Muriel P., Jimenez Vinas C., Alconchel F., Esteban Sinovas O., Gomez del Pulgar A., Fairen Oro C., Lopez Otero M., Figueroa Jimenez S., Claramonte Bellmunt O., Martinez Caballero J., Rubio-Perez I., Aguilar-Martinez M. M., Segura-Sampedro J. J., Olmedo Moreno C., Negre Parra D., Estevez Diz A. M., Martin-Balbuena R., Bustamante Recuenco C., Licardie Bolanos R. E., Fernandez P., Diaz Padillo A., Forero-Torres A., Alberdi San Roman I., Salvador Roses H., Merayo Alvarez M., Villarejo Campos P., Lopes Moreira C. C., Uriol Peralta P., Serrano Navidad M., Ripolles-Melchor J., Garcea A., Gomez Facundo H., Troncoso Pereira P., V Perez Guarinos C., Blaser B., Piazza G., Gagliardi B., Serin H., Yurdaor S. S., Arslan E., Kopac O., Uyanik A., Ozmen B. B., Tiftik E., Aksoy B., Yalcinkaya A., Ozoglu F., Kocer M. D., Bilicen G., Cinar E. N., Uslu O., Kaya Y., Demirci K., Wong J., Farhan-Alanie M. M. H., Suresh G., Asif A., Finch B. J., Bhahirathan Y., Herron J., Yi Tew Z., Obukofe R., Russell C., Suchett-Kay I., Netke T., Williams L., Kisiel A., Liu F. Y., Claireaux H., James P., Mondal A., Kalderon R., Nadama H. H., Al-Saraff Z., Tam J. P. H., Powell-Chandler A., Wood F., Gorgievska R., Ragavoodoo A., Thakrar C., Rojoa D., Palmer C., Davidson K., Giacci L., Hale J., Gan F. W., Makin-Taylor R., Hey C. Y., Toh C., Findlay J. M., Griffiths N., Ganesananthan S., Jasionowska S., Poustie M., Wong C., Turner T., Pyc W., Sloper W., Warner C., Coey J., Mason D., Sait S., Kowal M., Owen M., Saiyed A., Ashworth I., Akbari K., Curran M., Martin P., Parker D., Kwok K., Lye C., Ghaly M., Sammour T., Lewis D., Mundasad R., Wilkes A., Ctercteko G., Maslyankov S., Dimov R., Iliev S., Dimitrov D., Marek F., Orhalmi J., Skalicky P., Skalicky T., Chrz K., Christensen P., Worsoe J., Kristensen E. S., Emmertsen K. J., Loeve U. S., Mihaljevic A. L., Herrle F., Konstantinidis K. M., Korkolis D., Karanikas I., Vincenti L., Anania G., Borghi F., Agresta F., Maretto I., Parisi A., Bucci L., De Palma G., Guglielmi A., Cucinotta E., La Torre F., Cianchi F., Guerrieri M., Trompetto M., Persiani R., Micheletto G., Delrio P., Cantafio S., Ronconi M., Bisagni P. A. G., De Prizio M., Franceschi A., Galleano R., Cavallini M., Brescia A., D'Ambra L., Benevento A., Niolu P., Calgaro M., Colangelo E., Grottola T., Altomare D. F., Puleo S., Salamone G., Pietrabissa A., Poggioli G., Erdas E., Ottonello R., Tonini V., Selvaggi F., Sammarco G., Ceccarelli G., De Nisco C., Surgo D., Taglietti L., Ozolins A., Sivins A., Poskus T., Psaila J., Bemelman W. A., Graat L. J., Langenhoff B., Wijnhoven B. P. L., van de Ven A. H. W., Poelman M., Stassen L. P. S., Slooter G., Acherman Y. I. Z., Hoff C., Gerhards M. F., Stommel M. W. J., Hazebroek E. J., van Geloven A. A. W., Schasfoort R. A., van Leeuwen B. L., Tuynman J. B., van Tilburg M. W. A., Boerma E. G., Sharma P., Jenkins B., Bissett I. P., Herd A., Gordon A., Vernon D., Omundsen M., Ly J., Reddy A., Bonnet G., Harmston C., Morales M., Francisco V., Costa S., Manso A., Amorim E., Pereira J., Cardoso J., Ouro S., Caratao M., Nascimento C., Ribeiro da Silva B., Taranu V., Dias R., Mendes J., Allen M., Silva A., Carlos S., Barbosa E., Carneiro C., Ramos L., Lencastre L., Martins R., Silva-Vaz P., Ridgway P. F., McNamara D. A., Cahill R., Hogan A., Larkin J., O'Connell P. R., Negoi I., Abelevich A., Cuk V. M., Vician M., Ede C., Sardiwalla I., Mulira S., Montwedi D., Oyomno M., Sabia D., Portugal Porras V., Vigorita V., Sanz Ortega G., Garcia J., Espi Macias A., Blanco Antona F., Lujan Mompean J. A., Salvans Ruiz S., Villarejo-Campos P., Romero Simo M., Sanchez-Guillen L., Jimenez-Gomez L. M., Sanchez Lopez A., Golda T., Julia Bergkvist D., Nevado C., Noguera Aguilar J. F., cRicardo Felipe B., Septiem J., Rodriguez Sanchez A., Canete-Gomez J., Ruiz Montesinos I., Millan-Scheiding M., Prieto-Nieto I., Frasson M., Garcia Olmo D., Hubner M., Petermann D., Sauvain M. O., Ozben V., Gecim I. E., Disci E., Rencuzogullari A., Kurt A., Bisgin T., Pehlivan M., Isik A., Onur E., Leventoglu S., Haksal M. C., Erturk M. S., Keskin M., Guner A., Tutcu Sahin S., Ozbalci G. S., Pergel A., Albayrak D., Bruce D., Fearnhead N., Arthur J., Harron M., Beattie G., Titu L., Saunders M., Phillips J., Dindyal S., Cresswell B., Gercek Y., Lee J., Linn T., Faulkner G., Lockwood S., Rees J., Charalabopoulos A., Campbell B., Kontovounisios C., Amarnath T., Johnson M., Epanomeritakis E., Vigs S., Nastro P., Gilliam A., Smolarek S., Wilson T., Orbell J., McIntyre R., Agarwal T., Hainsworth P., Patel P., Vijay J., Liu B., Dhruva Rao P., Roxburgh C., Vipond M., Youssef H., Thorn C., Schizas A., Denley S., Bowley D., Das K., Cuming T., Saha A., Chung L., Pitt J., Davis P., Jones O., Taylor M., Bhargava A., Haji A., Watson N., Bloom I., Singh B., Norwood M., Gurjar S., Stylianides N., Mirza S., Evans M., Williams G., Patil P., Hernon J., Finch G., Green S., Chapple K., Fafemi O., Warusavitarne J., Samee A., Carden C., Ong L., Verma K., Joseph A., Rawat N., Pinkney T., Oke O., Glen P., Maxwell-Armstrong C., Oliphant R., Garner J., Moug S. J., Middleton S., Lund J. N., Smart N. J., Osborn G., Moore T., Raymond T., Knowles C. H., Hany T. S., Clarke R., Khera G., Brady R., Sellahewa C., Mason C., Torrance A., Lasithiotakis K., Knight J., Pullybank A., Ainsworth P., Reid F., Ramwell A., Maslekar S., George R., Skull A., Holtham S., Muhammad K., Lal R., Varcada M., Smith F. M., Howlader M., Defriend D., Kirk S., Richards T., Evans C., Borg C. M., Telford K., Sarfraz N., Busby K., Hollingshead J., Speake D., Pawa N., West D., Chadwick M., Komolafe O., Richardson S., Thornton M., Goede A., Osborne C., Bandyopadhyay D., Foong J., Lee Y. J., Liebenberg P., Mijalkov D., Wells A., Bull N., Ajmera A., Warburton T., Morgan S., Mahmoud A., Schachtel M., Mikhail B., Fomin I., Mekaeil B., Taylor N., Stevenson C., Drane A., Pahalawatta U., Lai L. T., Debiasio A., Jun H. J. S., Hengpoonthana R., Mendis D. M., Robb P. M., Lee H. J., Wyche A. A. B., Davis L. T., Chrimes A., Agarwal A., Zhao J., Williams S., Jayalath J. M. S. N., Khor S., Muddasani T., Childs S., Ridgway S., Blefari N. D. A., Tam H., Puchalski N., Ngai C., Mackenzie J., Johnson N., Holmes M., Zuzek R., Saluja T., Gould T., Goh Y. K., Selvaraj T., Beh Y. Z., Dudi-Venkata N. N., Horne D., Borrow J. L., Campbell C., Cousins G., Jackson L., Maheepala K., Zhao S., Holden E., Tutt L., Thompson B., Collins H., Louie F., Buckland B., Smith D., Chong C., Chua T. H., Nayak C., Redmond J., Tan R. R., Gramlick M., Teh J. S., Ng S. Y., Britten-Jones P., Mohd Rosli R., Pham H. D. V., Jegathees T., Coulter-Nile S. M. C. J., Gosselink M. P., Wang Y. L., Maciaszek M., Chrapko P. S., Nair A., Thirugnanasundralingam V., Muir K., Salibasic M., Pavlov V., Paycheva T., Lyulenina E., Kolev N., Nguen D., Mitkov Y., Mitkov E., Vladova P., Dimitrov V., Hussain M., Gabarski A., Ivanov T., Yotsov T., Ilieva I., Akisheva A., Shoshkova M., Nawaz E., Feradova H., Mladenov T., Jozaf V., Klail T., Pos M., Adel A., Sotona O., Bartos M., Amjad T., Maly O., Berec S., Hanusova M., Hurny M., Risko J., Ludvik M., Stercz M., Treskon R., Pospisil M., Hlavacova L., Tomanova D., Chodora S., Houdek O., Novicky R., Sobotkova K., Cha S., Suta Kimle K., Jirankova K., Bujda M., Paclik A., Trap A., Jurgens-Lahnstein J., Storm M., Damgaard I., Olawi F., Ehlern F., Raos M., Kristensen F. P., Bonnerup K., Amiri S., Enevoldsen M., Hojgaard Pedersen J., Jepsen B. N., Hillgaard T. K., Erichsen S. B., Nielsen C. V., Madsen C. P., Bjerke J., Skejo C. D., Aabling R. R., Sorensen J. 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A., De Angelis M., Mereu A., Adamo V., Bianco C., Ricciardiello M., Campanaro C., Panaccio P., Esposito L. M., D'Ascanio F., Pietroletti R., Chetta N., Aquilino F., Di Marco F., Amico A., Schembari E., Puglisi S., Licari L., Campanella S., Profita G., Falco N., Rotolo G., Venturelli P., De Marco P., Marciano M., Argenti F., Milani M. S., Malabarba S., Giambartolomei G., Vella I., Gronchi F., Ruggieri A., Roggiani A., Balsamo F., Gori A., Cuicchi D., D'Alessio R., Benvenuto D., Podda F., Cappellacci F., Salaris C., Sanna S., Marcialis J., Mosino L., Peddis M., Melis S., De Donno G., Aru A. C., Falsetti E., Lanari J., D'Errico U., Bianchini S., Figa F., Caiazzo A., Selvaggi L., Capozzolo A., Cerra C., Pirillo M., Cravano S., Libri I., Laquatra N., Isabello A., Truskovs A., Bartnick A., Malcevs E., Machatschek M. J., Alm J., Lapsa S., Delorme M., Zeynalov F., Larnovskis J., Sauka J., Bodrov D., Gailumsis R., Wiemann A. M., Muller N. L., Jelovskis I., Deksnis D., Bauermeister Potts O., Slimbajevs T., Samalavicius N. E., Nutautiene V., Zeromskas P., Jurgaitis J., Aliosin O., Slepavicius A., Eismontas V., Kybransiene M., Dulskas A., Kuliavas J., Kavaliauskas P., Kavaliauskaite R., Poskus E., Danys D., Kryzauskas M., Mikalauskas S., Rackauskas R., Drungilas M., Jotautas V., Strupas K., Cachia C., Cefai C., Youssef Y., Degaetano D., Debono S., Sammut M., Cassar J., Sammut K., Looijen R. C., Becker M. A. J., Comert D., te Molder L., Tromp J., Matthee E., Tissen Y. M., Brinkhuis E., de Vries H. S., 't Hart E., Beckers K., Bekker Y., Kakar S., van Smaalen T. C., Veen O. C., Dingemans S. A., van den Brink L. C., Vijgen G. H. E. J., van de Voort E. M. F., van der Pool A., van Rest K. L. C., Haak T., Sluijpers N. R. F., Molenaar C. J. L., Gordinou de Gouberville M. C., Saleh S., Mens M. A., Hoeks E. M., Nieuwenhuizen S., van Praag E. M., Westerduin E., Smit M. P. C. M., van der Lely S. J., Nasimi B., Gerdsen M., Stijns R. C. H., Leow T. Y. S., Penningnieuwland G., de Ruiter A., Ribbers T., Aarts C. A. M., Tulek M. S., de Jonge J., Kocak S., Alqethami H. J., Constansia R., van Elst P. C., Tissink M. W., Gruter A., Vroom Y., Voeten D. M., Feenstra T., Azzahhafi J., Bofarid S., Kip M., Saleh W., Franssen S., Boon C. L., Franssen R. J. M., Romaen I., Jense M. T. F., D'Souza J., Pascoe R., Scott A., Stark E., Mulholland K., Lau W. K., Smith B., Adams S. I. B., Shah N., Ling E., Young J., Jacobson A., Macfater H., Chen S. Y., Kilpatrick K., Kim D. H., Dixon S., Yassaie S., Welman D., Coulter J., Morreau M., Li E., Rankin A., Winders J., Skipworth C., Stanfield B., Henderson N., Chuang A., Maskill L., Ker H., McLaughlin S. J. P., Kearney J., Sprosen H., Kerckhoffs P., Alsadat R., Cherry R., Chapman D. A., Singh N., Clucas A., Gatenby G., Kelly B., Ruppeldt P., McIntosh N. D., Koh S., Wilms H., Dalzell F., Tewhaiti-Smith J., Kader T., Yam S. 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F., Parreira R., Faustino A., Medeiros N., Castro R., Soares B., Resendes M., Almeida P., Cruz A., Vaz Pinto G., Sousa D., Costa Santos D., Silva F., Fialho G., Reia M., Pratas N., Costa C., Costa J., Morais S., Machado A., Horta V., Rocha-Melo M., Patricio J., Pereira M., Lima R., Cinza A. M., Oliveira J., Velez C., Borges F., Simoes J., Botelho P., Cismasiu B., Alves D., Dias B., Goncalves J. P., Valente P., Freire L., Saraiva R., Moreira M., Fragoso M., Guimaraes J., Cruz G., Ribeiro J., Borges da Ponte I., Almeida S., Martins A. R., Louro T., Morgado M., Ferreira A. S., Alves M., Oliveira N., Lerias R., Estalagem I., Botelho C., Bartolo J., Fidalgo Antunes C., Cabral F., Brito Silva F., Dias Matos A., Santos M., Cunha R., Sousa M., Canotilho R., Correia A. M., Martins P. C., Jardim J. A. M., Domingos S. P., Baiao J. M., Rocha B. S., Lopes N. M. R. O., Jordao D. M., Angelo M. D., Caroco T., Gomes J. R., Monteiro R. G., Varghese S., Boyle E., Aljohmani L., Alexander J., Graziadei V., McCaughey C., Jain A., Ramanayake H., Sabnani R., Colon L. F., Bansal N., Stephens I., Tan R., Sharma S., Doherty G., Fenn S., Mulhare E., Walsh M., Leavey C., Costigan O., Griffin S., Dockry E., Khogali E., Aly A. K., McPhedran R., O'Gorman D., Vermeulen D., Dervan L., Kang S. J., Dixon O., Morrissey E., Compton M., Pentony A. R., Piong C. L., Nossier R., Hanna J., Sabir K., Eow S. Y., Ladak N., Boersma D., Kamath P. J., Soh T. B. W., Dyer A. H., Chee S. Y., Tan I. X. H., Kelliher A., Adeusi L., Howarth N., McCawley N., O'Neill A., Jones M. R., Saleh R., Singh A., Senaratne R., Kakodkar P., Balasubramanian I., Al-Salihi A., Vyas V., Vedadi A., Popescu S. S., Piras K., Ciubotaru C. I., Romanova E., Ponomarev N., Savchenko A., Luzan R., Lutovinova E., Gavrilina A., Barkovskaya A., Kudelkina N., Topchubaev D., Radulovic R., Milosevic K., Bojicic J., Gencic M., Jankovic U., Zubowicz M., Suchan P. K., Gerstmeier J., Brazitikou E., Fytrou E., Celik M., Dubovsky M., Schmalenbeck J., Sautter S. C., Ceyran H., Fitchat N., Mathebula S., Chauke J., Mculu W., Ngwenya Z., Withey K., Piperidis A., Toyi Y., Nicolaides A., Jaffer T., Sparke A., Van Staden N., McDuling C. R., Claassen L., Kruger C., Weyers J., Lecler J., Yebes A., Mana O. C., Gomez H., Riba L., Perez J., Casaval Cornejo L., Vicente Rodriguez I., Jimenez Escovar F., Calvo Fernandez M., Portugal Martinez A., Badiola Bergara I., Landaluce Olavarria A., del Pozo Andres E., Samartin Toimil C., Primo Alvarez J. C., Rodriguez Fernandez L., Ortega C., Ossola M. E., Camarero E., Martinez Illan M., Aranda Garcia L., Lazaro Cardona M., Montalvo Olmedo C., Livianos Arias-Camison P., Nieto Arranz J. M., Mateos Sexmero M. J., Diego Alonso E., Izquierdo Moreno A., Margarida A., Pando B., Liquete Marin L., Perez Calle M., Ramos Cordero M. J., Sagredo Cuartango A., Sanchez E., Marcos Rodrigo A., Martinez Diaz J. M., Ruiz Manzanera J. J., Navarro Barrios A., Rodriguez Pedreno L., Garcia Moreno P., Garcia Gomez M., Rodrigues K., Platero Diago J., Veras Lista M., Rifa Terricabras S., Butler Sanz L., Alberch Camprubi E., Rico Ferrandez M., Puig Lao E., De Pablo Miro M., Alberca-Paramo A., Alia Verdejo T., Canete-Manzanares J., Molina-Florez M., Garcia Hernandez L. C., Orozco Nunez S., Suarez-Sanchez M., Martin-Fernandez J., Soriano Liebana M. M., Campo Betancourth C. F., Sevila Mico S., Fernandez A., Curtis C., Bosch M., Triguero D., Bosch Ramirez M., Ramayo Diaz N., Gonzalez Caraballo I., Pascual Vicente T., Orue-Echebarria M. I., Sanchez-Calvo L., Wang D., Trueba-Collado C., Morales Bernaldo de Quiros J. T., Lima Pinto F., Nunez OSullivan S., Ramos Jimenez F. A., Perez Ortega A., Trujillo Barbadillo A., Romero Pujana E., Fernandez Illera M. V., De La Llave Serralvo A., Mestres N., Cuello E., Merichal M., Sierra J. E., Escoll J., Rufas M., Pinillos A. I., Ortega J., Vivas Angeles P., Vives Figueras R., Baena Sanfeliu E., Campillo Alonso B., Alberich Prats M., Duran Arrocha J., Cornella Garceso N., Uribe Galeano C., Delisau Puig O., Castro A., Codony Bassols C., Fernandes N., Garcia Adamez J., Caula Freixa C., Sanchez M. J., Martin-Borregon P., Quevedo A., Martinez J., Marin J. M., Rodriguez P., Garcia Orozco J. J., Ferrusola Diaz D. A., Garcia Jimenez M. L., Castro Diez L., Mosquera Fernandez C., Alonso Batanero E., Cifrian Canales I., Calzada M. G., Recuenco C. B., Martin M. C., Esteban Avendano I., Jimenez Relimpio C., Lancho Lavilla P., Blanco Bartolome I., Gomez Cano I., Blasco Andres C., Alonso-Poza A., Dieguez B., Losada M., Gilsanz C., Garcia-Vico A., Roman-Rando A., Sanchez-Galvez M. A., Bersabe-Alonso I. M., Vadillo-Bohorquez A., Gutierrez Rios R. D., Eizaguirre Ubegun M., Novo Sukia I., Uribe Isado M., Ibanez Alda M., Pastor Idoate C., Abad-Motos A., Marinez-Hurtado E., Salvachua-Fernandez R., Padilla Zegarra E. D., Franco M., Martinez A., Ramos Martin P., Mate Mate P., Marcano Chavez C., Ayllon H., Jeri-McFarlane S., Soldevila-Verdeguer C., Pineno-Flores C., Ambrona-Zafra D., Fernandez-Vega L., Gil-Catalan A., Craus-Miguel A., Pujol-Cano N., Sena-Ruiz F., Gomez Jurado M. J., Alberti Delgado P., Bordanova Reverter A., Belzunce-Capo J. F., Verdaguer Tremolosa M., Lin Q., Muniesa C., Avelino L., Cholewa H., Sancho-Muriel J., Navasquillo M., Navio A., Abello D., De Jesus M., Alvarez E., Garcia J. M., Gil A., Giordano H. E., Mignon G., Vanoni A., Henkens A., Jarrar G., Odovic M., Willemin M., Milliet O., Hahnloser D., Demartines N., Teixeira H., Pittet O., Haller M. L., Huot A., Kefleyesus A., Bugmann A., Piotet L. M., Meijers L., Kurtoglu G. K., Sel E. K., Isler V. C., Yilmaz B. S., Adiyaman C., Kara M., Demirkaya H. C., Korkmaz H. K., Pektas A. M., Guner B., Islek E. C., Tombul H. B., Boztug C. Y., Tinaz A., Yilmaz M., Karaman Y., Akin F. A., Dansuk S., Bascavus M., Kaya M., Kutlu B., Seker M. C., Erten V., Memis U., Kocak Z. B., Karapinar Y. E., Fakirullahoglu M., Koseoglu E., Yeni M., Aykun N., Agca M. H., Bilen C., Kilinc I., Atar C., Kilic V., Aktuna C., Aba M., Alim Y. E., Binbuga M., Kurklu O., Ceylan C., Yilmaz S., Calar S. N., Yildirim N., Yavuz G., Can B., Cesmeli E., Kus D., Kavar R. C., Cevlik A. D., Cengiz U., Turk E. G., Yilmaz I., Erdonmez H., Gursoy F., Kara H., Onsal U., Ozbek M., Kasar P. A., Ipor A., Ozen D., Olmez M., Altintas E., Toklu R., Saricicek T., Tipi O. U., Benli G. E., Tasdelen I., Tura A., Ucar A., Ekci B., Bilgili A. C., Kiraz I. N., Aksoy H., Basak A., Erdem M., Kayacan S., Sahin C., Uysal M., Karakus K., Altiner S., Demirci Z. S., Eren E., Yavas M., Aksoy A. B., Karagoz E., Sabanci R., Tumer S. S., Kargici K., Banaz T., Abdulrahman S. M. F., Yesilsancak M., Yanikoglu E., Karabulut A., Yilmaz D., Kuyumcu O. F., Kutluk F., Emiroglu B., Mollavelioglu B., Gereklioglu D., Guler M., Toprak S., Afsar H. B., Guler S. E., Alizade E., Alemdag G., Ulusahin M., Gul E. B., Yildirim R., Semiz A., Bektur G., Tomas K., Yarenci E., Demiroglu Y., Sunal A., Baykan B., Abbasguliyev H., Mutlu V., Mahmoudi Y., Dossa S. A. A., Mizan S. R., Demirtas B., Cavus T., Yuksek A., Mazlum S. S., Yelkenci C., Baran T., Satilmisoglu M., Sahin A. Z., Kilinc A., Isik K., Yumurtaci O., Emin A., Girit C., Yildirak M. K., Senyigit E., Guldag A., Soyleyici B., Aytin Y. E., Akay F. E., Iskan N. G., Mutlu B., Sunay A. O., Tie-Gill T., Ramsay G., De Paola L., McGuckin S., Alshakhs A., Ahmeidat A., Goergen N., Ali Z., Mullarkey L., Walshe R., Lewis E., Berry B., Moneim J., Mookerjee S., Christy S., Ojofeitimi O., Carroll L., Hylands A., Delaugere L. P., Reveendran D., Coulter C., Ralston C., Laverty L., Gallagher P., Ahmed A., Yeo Y. Q., Elliott D., Bennett J., Mcnamara M., Sivarajah S., Dunmore C., Aitken G., Nair M., Aly M. 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L., McCusker C., Hlukha L., Pike G., Kamel F., Thakkar R., Donaldson C., Sequeira Campos M., Armitage M. N., Hussain A. S., Hardy B., Hassan Serry M. Y., Bradbury M., Osunronbi T., Tam L. Y. C., Khanan Kaabneh A., Lawther J., Fisher P., Tribedi T., Moosa A., Ramdin A., Goble M., Downs E., Wheldon L., Baggus E., Mandal A., Nayeem A., Ahmed S., Fradley W., Wilson C., Gallagher S., Criswell T., Ward J., Mukkavilli A., Stubbs B., Fordyce W., Suchdev N., Wei Lim S., Sookramanien S. R., Chan A., Bointas G., Paul M., Ward K. L., Bagnall M., Pherwani S. A., Wang K., Mitchell L., Heyworth J., Ayyar S., Polson R., Mackenzie E., Doyle N., Habib Z., Zardab M., Sartaj F., Farooq H., Tabibi M., Drury D. J., James S. J., Barnett R., Teasdale A. B., Richardson E. T. J., Thomas D. A., Williams R. L., Najabat-Lattif H. F., Cahya E., Lou G., Coyle M., Homyer K., Zhu L. Y., Woods M., Chang J., O'Callaghan H., Suchett-Kaye I., Mihailidis T. H., Alawattegama H., Seite E., Barrett A., Riordan E., Lam W., Dowdeswell M., Mulvenna C., Awokoya O., Gurowich L., Dhera K., Hayat S., Tincknell L., Spazzapan M., Teeling F., Sysum K., Latter J., Latter M., Khan S., Guruswamy M., Beedham W., Brazier E., Elghobashy M., Bajaj M., Mann H., Etel E., Woodmass M., Hayden H., Ali Y., Husain S., Arnold A., Pedersen A. C., Cunha P., Ahmed M., Al Zawawi S., Kudva V., Theodoropoulou K., Miscampbell M., Robinson A. V., Johnston J., Dharni A., Lamb S., Westerman T., Evans E., Campbell L., Gillespie M., Cheong C. M., Kulathevanayagam K., Varghese A., Ike S. I., Chu T. S. M., Baljer B., Mogg J. A. W., Rai P., Claireaux H. A., Williams M., Smillie R., Goetz J., Appleby E., Fadipe T., Vaughan-Burleigh S., Puri G., Hussain P., Flather R., Cutler A., Pathak S., Sheldon J., Collicott T., al-Ausi M., Jovaisaite A., Shah S. M., Khalid N., Gutmann D., Davison S., Alame Y. J., Syed L., Owen W. J., Ahsan S. D., Anthony-Uzoeto U., Macleod Hall C., Zheng S., Wynter K., James C., Sapre D., Ghosh R., Baird J., Cockburn L., Blackwood O., Simpson W., Jeong S., Bishop S., Bate R., Hobson C., Adam A. H., Redclift C., Do J., Adeleye O., Poli F., Batterham A., Brown S., Parekh J. N., Clay W., Pieri K., Jackson A., Saxena A., Gurung B., Oyebola T., O'Brien F., Djeugam B., Gardezi S., Ul-Hasan S., Martin-Hernandez M. P., Sisley M., Modi S., Antakia R., Elbayouk A., Soh Y. J., Mather J., Yusuf Z., Al-Sarraf Z., Naja M., Rassool S. B., Convill J., Nikookam Y., Warsame A., Pace C., Kiandee M., Ridwan R., Carey C., Hirri F., McMillan M. J. A., Ling J. J., Pendelbury L., Kerimzade K., Tang A., Howard E. O., Humayun S., Wadsworth O. J., Tan K., Abdelhameed F., Haglund C., Radnaeva I., Hu N., Rambhatla S., Waldron D., Madahar P., Malik S., Meney L. C., Ibrahim I., Kang C. K., Chiu J. Z. J., Livie V., Ibrahim B., Khalil M., Pooley G., Shishkin B., Docherty J., Southgate A., Coomes A., McGee F., Flanagan S., Tan Q. J., Anwar H., Clough R., Chrisp B., Cassels J., Cross G. W. V., Mercer L., Mercer C., Refalo A., Hadley R., McTighe A., Farrow F., Brodie A., Davis G., Shah D. R., Bowers C., Patel S., Morice O., Burzic A., Cheung J., Shashidhara A., Theodoraki G., Birk J., Ong A., Ng M. P. E., Wong R. T. W., Maese S., Yeap B., Iqbal Z., Rojoa D. M., Cabaleiro Barciela C., Ruddy C. M., Lindwe S., Qamar Y., Chuita S., Melaugh T., Hall J. D., Kouli O., Hassane A. S. I., Azhar A. W., Tan T. K., Perchard W., Scurr T., Campbell E., Kelk L., Ghosh A., Gibbins A., Mala D., Loizidou A., Hall O., Mecia L., Hew C., Varathan K., Tong L., Chandrasekar B., Buchanan E., O'Connell M., Kwak S. Y., Ong E. 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T., Wynell-Mayow W., Udayachandran V., Alsoof D., Ekert J., Joseph N., Zulkefley N., Hunt G., Christodoulou T., Wright O., Soman S., Jamal M., Beqiri S., Borgas P., Christie S., Pereira F., Browne S., Yiu J., Dworkin A., Brayley J., Palmer A., Charalambos M., Jones C. S., Toner S., Cowden R., Lee L., Nicol P., Holman O., Imtiaz M., Albert V., Leung S. P., Erotocritou M., Stroud R., Wilkin R., Thomson W., Mackee L., G N., Bei Y., Mckenna Favier S., Ibrahim A., Kler A., Reynolds L., Mohamed S. H., Majeed Y., Fakim B., Jones A., Liversedge G., Carrington Z., Windebank J., Izzarina A., Akbani U., Craven J., Aldarragi A., Harding S., Millward A., Bedford M., Gopalan V., Midgen A., Khadka P., Cheng O., Taneja S., Manobharath N., Kok J. Y., Lim D. W. E., Buick T., Boland M., Piya S., Devlin R., Fairfield C. J., George R. J., Rahi M., Zaman S., Hajiev S., Ross T., Crisp E., Thompson C., Charalambous A., Hollywood J. L., Hammond R. F. L., Matthews J., Mendonca V., Spinty J., Khan K., Cheng J., Glynn N., Muhammad U., Khan M., Anderson L., Mccormack K., Mak J., Patrawala S., Milinkovic N., Schofield R., Chauhan M., Hartley L., Hind J., Nelson L., Ratnasingham D., Whitehead T., Dimitriadis S., Marshall K., Flint E. J., Horner C., Heybourne A., Morgan H., Wickstone C., Panagiotou D., O'Connell E., Dean K., Iqbal R., Walsh L., Yu N., Rana N., Massie E., Ng J., Jung M., Lee Y. D., Harris M., White S., Boev B., Tonchev P., Prochazka V., Skalicky A., Ravn S., Ojakaar A., Dorr-Harim C., Koutserimpas C., Giraudo G., Armellini A., Ruzzenente A., Mazzeo C., De Padua C., Realis Luc A., Maroli A., Giani I., Cufari M. E., Vitali M., Gusai G. P., Quattromani R., Virgilio E., Berti S., Di Mola Ospedale SS Annunziata F. F., Papagni V., Tuminello F., Vittori L., Longheu A., Loche G. A., Braccio B., De Luca E., Resta G., Ancans G., Tamosiunas A., Petrulionis M., Andrejevic P., Stellingwerf M. E., Abdulrahman N., van de Pas K. G. H., Thomas G., Brandsma A. M., Davids J., Rottier S. J., de Roy van Zuidewijn D., Hawkins R., Ong H. I., Li Y., Desmond B., Winstanley J., Martins M., Americano M., Frade S., Senhorinho R., Peixoto R., Alves-Vale C., Lamas M., O'Connor D. B., Hoo M., Gopaul A., Scanlon K., O'Dwyer N., Jovanovic M., Panyko A., Van Vuuren S., Centeno A., Bernado I. R., Paniagua Garcia Senorans M., Gonzalez Amor L., Cuenca Ramirez A., Abrisqueta J., Estaire Gomez M., Arroyo A., Cerdan C., Gomez Romeu N., Enriquez-Navascues J. M., Collado-Roura F., Curchod P., Gaspar S., Imadalou L., Mutlu D., Akyol C., Uygur F. A., Eray I. C., Biyiklioglu O., Cetin M. F., Isik A. E., Karip B., Dogan H., Sarigul L., Tunc E., Aydin T., Bodur S., Karabulut K., Francis A. A., Al-hadithi A., To N., Lau I. S. F., Smith E., Mahapatra S., McAuliffe O., Imam L., Akram B., Hossaini S., Davies R., Ko M., Collins J., Pandya A., Reilly S., Archer J., Auty C., Roche C. D., Livie J., Chaudhry F. A., Ntakomyti E., Diallo R., Bylinski T., Wright J., Masiha E., Tung J., Shirazi B., Neilson A., Epton S., Patel N., Trussell S., Couldrey A., Donnelly C., Eftychiou S., Glasbey J.C., Bibi S., Pata F., Ozkan B.B., Van Straten S., Hodson J., Chapman S.J., Blanco-Colino R., Pellino G., Sgro A., Soares A., van Elst T., Nepogodiev D., Borakati A., Bath M.F., Yasin I.H., Mclean K., Arthur T., Kovacevic M., Delibegovic S., Karamanliev M., Swamad M., Zebrak R., Paramasivam R., Martensen A., Larsen H.M., Radeker L., Frey P.E., Kechagias A., Venara A., Duchalais E., Ioannidis A., Pasquali S., Simioni A., Farina V., Podda M., Lorenzon L., ItSURG I., Schaeff V., Otto A., Jakubauskas M., van Elst T.R., Chu M., Fagan P.V.B., Wells C.I., Alagoa Joao A., Juloski J., Perez-Ajates S., Anabitarte Bautista O., El Kasmy Y., Espin-Basany E., Clerc D., Ciubotaru C., Popescu S., Yanishev A., Lee S., Yagiz Sen A., Aktas M.K., Baki B.E., Yuksek B., Kamarajah S., Khaw R.A., Mills E., Goodson R., Thakral N., Collaborative S., Ablett A.D., Adra M., Kwek I., Khan S.M., Quinn P., Manley L.R., Badran A., Ramjeeawon A., Campbell A., Tan H.L., Rye D.S., Rajaraman N., Norman J.G., Vutipongsatorn K., Solomou G., Akhbari M., Ali A., Murray V., Baker D.M., Brandao B.D., Stainer B., Thavayogan R., Jones D., Onafowokan O.O., Gharooni A., Dabab N., Carlton-Carew S., Kungwengwe G., Gabriel M., Sewart E., Shortland T.C., Lawday S., Pockney P., Dawson A., Brumfitt C.D., Stewart P., Ng B., Luong J.K., Ivanov V., Borisova A., Neykov V., Kuncarova K., Kolosova B., Antonova T., Farkasova M., Harbjerg J.L., Brandsborg S., Brinck S., Kjaer M.D., Mark-Christensen A., Unbehaun K.P., Dalsgaard P., Lycke K.D., LeNaoures P., Brigand C., Dumange E., Gout M., Moehwald C., Prem M., Alhalabi O., Sliwinski S., Krupp J., Gablenz E., Schmitzer L., Kopp A., Steinle J., Gsenger J., Pohl L.J., Riccardi M., Christodoulou I.M., Konstantinidis M., Machairas N., Zoikas A., Balalis D., Manatakis D.K., Aguilera M.L., Marano L., Fleres F., Lovisetto F., Sasia D., Segalini E., Pata G., Lucchi A., Sagnotta A., Campagnaro T., Petrelli F., Gallo G., Papandrea M., Testa V., Sinibaldi G., Di Candido F., Colombo F., Perrone G., Biancafarina A., Canonico G., Pagnanelli M., Curletti G., Bini R., de Manzoni Garberini A., Impellizzeri H., Cillara N., Tutino R., Picciariello A., Coletta D., Savino G., Ferrara F., Tamini N., Talamo G., Parini D., Giamundo P., lo Conte A., Pagano G., Ripetti V., Pesce A., Menduni N., Giudicissi R., Goldin E., Rega D., Belli A., Andriola V., Gordini L., Foppa C., Piccolo G., Birindelli A., Ferrari C., Ballarini Z., Tirelli F., Milone M., De Rosa M., Pipitone Federico N.S., Molteni B., Tilocca P.L., Sancini G., Piozzi G.N., Lauretta A., Poillucci G., Mulas S., Simcikas D., Portelli L., van Wijnbergen J.W.M., Dinger T.L., ten Doesschate S.F.H., van Dalen A.S.H.M., van den Bos D.D., Hansmann M., Medina Feliz J., Kuiper S.Z., Abdulrahman Z., Pruijssers S.R., Farik S., Elliott B.M., Geneta V.P., Wilton S., Kandelaki H., Peng S.L., Campbell S., Lim Y.K., Yassaie S.S., Murray M., Haran C., Tan J., Castro J., Laranjeira A., Catarino S., Neves-Marques C., Correia J.G., Vieira B.N., Quintela A.C., Serra M.L., Maciel J., Cunha M., Aparicio D.J., Neves J., Azevedo J., Romano M., Eiro F., Romano J., Monteiro C., Claro M., Almeida M.R., Peyroteo M., Machado N.D., Capote H., Ferreira M., Sousa X., Devesa H., Cavadas D., Guerreiro I., Costa M., Rosete M., Salman M., English C., Mohammed N., Litvin A., Cuk V.V., Meszarosova K., Jaich R., De Lima H., Brooks S., Marx M., Nshalati Salvation M., Garcia Cardo J., Mora-Guzman I., Sancho Muriel J., de Andres Olabarria U., Muriel P., Jimenez Vinas C., Alconchel F., Esteban Sinovas O., Gomez del Pulgar A., Fairen Oro C., Lopez Otero M., Figueroa Jimenez S., Claramonte Bellmunt O., Martinez Caballero J., Rubio-Perez I., Aguilar-Martinez M.M., Segura-Sampedro J.J., Olmedo Moreno C., Negre Parra D., Estevez Diz A.M., Martin-Balbuena R., Bustamante Recuenco C., Licardie Bolanos R.E., Fernandez P., Diaz Padillo A., Forero-Torres A., Alberdi San Roman I., Salvador Roses H., Merayo Alvarez M., Villarejo Campos P., Lopes Moreira C.C., Uriol Peralta P., Serrano Navidad M., Ripolles-Melchor J., Garcea A., Gomez Facundo H., Troncoso Pereira P., V Perez Guarinos C., Blaser B., Piazza G., Gagliardi B., Serin H., Yurdaor S.S., Arslan E., Kopac O., Uyanik A., Ozmen B.B., Tiftik E., Aksoy B., Yalcinkaya A., Ozoglu F., Kocer M.D., Bilicen G., Cinar E.N., Uslu O., Kaya Y., Demirci K., Wong J., Farhan-Alanie M.M.H., Suresh G., Asif A., Finch B.J., Bhahirathan Y., Herron J., Yi Tew Z., Obukofe R., Russell C., Suchett-Kay I., Netke T., Williams L., Kisiel A., Liu F.Y., Claireaux H., James P., Mondal A., Kalderon R., Nadama H.H., Al-Saraff Z., Tam J.P.H., Powell-Chandler A., Wood F., Gorgievska R., Ragavoodoo A., Thakrar C., Rojoa D., Palmer C., Davidson K., Giacci L., Hale J., Gan F.W., Makin-Taylor R., Hey C.Y., Toh C., Findlay J.M., Griffiths N., Ganesananthan S., Jasionowska S., Poustie M., Wong C., Turner T., Pyc W., Sloper W., Warner C., Coey J., Mason D., Sait S., Kowal M., Owen M., Saiyed A., Ashworth I., Akbari K., Curran M., Martin P., Parker D., Kwok K., Lye C., Ghaly M., Sammour T., Lewis D., Mundasad R., Wilkes A., Ctercteko G., Maslyankov S., Dimov R., Iliev S., Dimitrov D., Marek F., Orhalmi J., Skalicky P., Skalicky T., Chrz K., Christensen P., Worsoe J., Kristensen E.S., Emmertsen K.J., Loeve U.S., Mihaljevic A.L., Herrle F., Konstantinidis K.M., Korkolis D., Karanikas I., Vincenti L., Anania G., Borghi F., Agresta F., Maretto I., Parisi A., Bucci L., De Palma G., Guglielmi A., Cucinotta E., La Torre F., Cianchi F., Guerrieri M., Trompetto M., Persiani R., Micheletto G., Delrio P., Cantafio S., Ronconi M., Bisagni P.A.G., De Prizio M., Franceschi A., Galleano R., Cavallini M., Brescia A., D'Ambra L., Benevento A., Niolu P., Calgaro M., Colangelo E., Grottola T., Altomare D.F., Puleo S., Salamone G., Pietrabissa A., Poggioli G., Erdas E., Ottonello R., Tonini V., Selvaggi F., Sammarco G., Ceccarelli G., De Nisco C., Surgo D., Taglietti L., Ozolins A., Sivins A., Poskus T., Psaila J., Bemelman W.A., Graat L.J., Langenhoff B., Wijnhoven B.P.L., van de Ven A.H.W., Poelman M., Stassen L.P.S., Slooter G., Acherman Y.I.Z., Hoff C., Gerhards M.F., Stommel M.W.J., Hazebroek E.J., van Geloven A.A.W., Schasfoort R.A., van Leeuwen B.L., Tuynman J.B., van Tilburg M.W.A., Boerma E.G., Sharma P., Jenkins B., Bissett I.P., Herd A., Gordon A., Vernon D., Omundsen M., Ly J., Reddy A., Bonnet G., Harmston C., Morales M., Francisco V., Costa S., Manso A., Amorim E., Pereira J., Cardoso J., Ouro S., Caratao M., Nascimento C., Ribeiro da Silva B., Taranu V., Dias R., Mendes J., Allen M., Silva A., Carlos S., Barbosa E., Carneiro C., Ramos L., Lencastre L., Martins R., Silva-Vaz P., Ridgway P.F., McNamara D.A., Cahill R., Hogan A., Larkin J., O'Connell P.R., Negoi I., Abelevich A., Cuk V.M., Vician M., Ede C., Sardiwalla I., Mulira S., Montwedi D., Oyomno M., Sabia D., Portugal Porras V., Vigorita V., Sanz Ortega G., Garcia J., Espi Macias A., Blanco Antona F., Lujan Mompean J.A., Salvans Ruiz S., Villarejo-Campos P., Romero Simo M., Sanchez-Guillen L., Jimenez-Gomez L.M., Sanchez Lopez A., Golda T., Julia Bergkvist D., Nevado C., Noguera Aguilar J.F., cRicardo Felipe B., Septiem J., Rodriguez Sanchez A., Canete-Gomez J., Ruiz Montesinos I., Millan-Scheiding M., Prieto-Nieto I., Frasson M., Garcia Olmo D., Hubner M., Petermann D., Sauvain M.O., Ozben V., Gecim I.E., Disci E., Rencuzogullari A., Kurt A., Bisgin T., Pehlivan M., Isik A., Onur E., Leventoglu S., Haksal M.C., Erturk M.S., Keskin M., Guner A., Tutcu Sahin S., Ozbalci G.S., Pergel A., Albayrak D., Bruce D., Fearnhead N., Arthur J., Harron M., Beattie G., Titu L., Saunders M., Phillips J., Dindyal S., Cresswell B., Gercek Y., Lee J., Linn T., Faulkner G., Lockwood S., Rees J., Charalabopoulos A., Campbell B., Kontovounisios C., Amarnath T., Johnson M., Epanomeritakis E., Vigs S., Nastro P., Gilliam A., Smolarek S., Wilson T., Orbell J., McIntyre R., Agarwal T., Hainsworth P., Patel P., Vijay J., Liu B., Dhruva Rao P., Roxburgh C., Vipond M., Youssef H., Thorn C., Schizas A., Denley S., Bowley D., Das K., Cuming T., Saha A., Chung L., Pitt J., Davis P., Jones O., Taylor M., Bhargava A., Haji A., Watson N., Bloom I., Singh B., Norwood M., Gurjar S., Stylianides N., Mirza S., Evans M., Williams G., Patil P., Hernon J., Finch G., Green S., Chapple K., Fafemi O., Warusavitarne J., Samee A., Carden C., Ong L., Verma K., Joseph A., Rawat N., Pinkney T., Oke O., Glen P., Maxwell-Armstrong C., Oliphant R., Garner J., Moug S.J., Middleton S., Lund J.N., Smart N.J., Osborn G., Moore T., Raymond T., Knowles C.H., Hany T.S., Clarke R., Khera G., Brady R., Sellahewa C., Mason C., Torrance A., Lasithiotakis K., Knight J., Pullybank A., Ainsworth P., Reid F., Ramwell A., Maslekar S., George R., Skull A., Holtham S., 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E., Ciccioli E., Galgano A., Zuin M., Bettella A., Barina A., Vendramin E., Palano G., Schiavone D., Di Cintio A., Gemini A., Trastulli S., De Luca M., Desiderio J., Gubbiotti F., Cigognini M., Zaffaroni G., Maffioli A., Colombo S., Bondurri A., Sampietro G., Foschi D., Manigrasso M., Danzi M., Amato R., Anastasio L., Mastella F., Basile R., Peltrini R., Marra E., Luglio G., Giglio M., Anoldo P., Vertaldi S., Grimaldi L., Tammaro N., Pedrazzani C., Turri G., Lazzarini E., Conti C., Vulcano I., Bertilone E., Pintabona G., Viscosi F., Cerasari S., Galiffa G., Lapolla P., Del Basso C., Cirillo B., De Toma G., Fazzi K., Bini S., Coratti F., Montanelli P., Grandi S., Nelli T., Ben Khaled N., Cammelli F., Ferrini E., Billo M.E., Marrosu A.G., Scognamillo F., Pala C., Attene F., Carboni L., Ruggiu M.W., Gabbas G., Marziali I., Mazzocato S., Vergari R., Piazzai F., Kubolli I., Aggiusti A., Paolucci A., Ortenzi M., Olivieri M., Belluco C., Antona A.D., Basso S., Morino M., Mistrangelo M., 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F., Sysum K., Latter J., Latter M., Khan S., Guruswamy M., Beedham W., Brazier E., Elghobashy M., Bajaj M., Mann H., Etel E., Woodmass M., Hayden H., Ali Y., Husain S., Arnold A., Pedersen A.C., Cunha P., Ahmed M., Al Zawawi S., Kudva V., Theodoropoulou K., Miscampbell M., Robinson A.V., Johnston J., Dharni A., Lamb S., Westerman T., Evans E., Campbell L., Gillespie M., Cheong C.M., Kulathevanayagam K., Varghese A., Ike S.I., Chu T.S.M., Baljer B., Mogg J.A.W., Rai P., Claireaux H.A., Williams M., Smillie R., Goetz J., Appleby E., Fadipe T., Vaughan-Burleigh S., Puri G., Hussain P., Flather R., Cutler A., Pathak S., Sheldon J., Collicott T., al-Ausi M., Jovaisaite A., Shah S.M., Khalid N., Gutmann D., Davison S., Alame Y.J., Syed L., Owen W.J., Ahsan S.D., Anthony-Uzoeto U., Macleod Hall C., Zheng S., Wynter K., James C., Sapre D., Ghosh R., Baird J., Cockburn L., Blackwood O., Simpson W., Jeong S., Bishop S., Bate R., Hobson C., Adam A.H., Redclift C., Do J., Adeleye O., Poli F., Batterham A., Brown S., Parekh J.N., Clay W., Pieri K., Jackson A., Saxena A., Gurung B., Oyebola T., O'Brien F., Djeugam B., Gardezi S., Ul-Hasan S., Martin-Hernandez M.P., Sisley M., Modi S., Antakia R., Elbayouk A., Soh Y.J., Mather J., Yusuf Z., Al-Sarraf Z., Naja M., Rassool S.B., Convill J., Nikookam Y., Warsame A., Pace C., Kiandee M., Ridwan R., Carey C., Hirri F., McMillan M.J.A., Ling J.J., Pendelbury L., Kerimzade K., Tang A., Howard E.O., Humayun S., Wadsworth O.J., Tan K., Abdelhameed F., Haglund C., Radnaeva I., Hu N., Rambhatla S., Waldron D., Madahar P., Malik S., Meney L.C., Ibrahim I., Kang C.K., Chiu J.Z.J., Livie V., Ibrahim B., Khalil M., Pooley G., Shishkin B., Docherty J., Southgate A., Coomes A., McGee F., Flanagan S., Tan Q.J., Anwar H., Clough R., Chrisp B., Cassels J., Cross G.W.V., Mercer L., Mercer C., Refalo A., Hadley R., McTighe A., Farrow F., Brodie A., Davis G., Shah D.R., Bowers C., Patel S., Morice O., Burzic A., Cheung J., Shashidhara A., Theodoraki G., Birk J., Ong A., Ng M.P.E., Wong R.T.W., Maese S., Yeap B., Iqbal Z., Rojoa D.M., Cabaleiro Barciela C., Ruddy C.M., Lindwe S., Qamar Y., Chuita S., Melaugh T., Hall J.D., Kouli O., Hassane A.S.I., Azhar A.W., Tan T.K., Perchard W., Scurr T., Campbell E., Kelk L., Ghosh A., Gibbins A., Mala D., Loizidou A., Hall O., Mecia L., Hew C., Varathan K., Tong L., Chandrasekar B., Buchanan E., O'Connell M., Kwak S.Y., Ong E.H., Gardner S., Lim J., Maden C., Illahi M., Xuan Tan Z., Stahl R., Stahl J., Hickman A., Collett D., Goolam-Mahomed Z., Allen B., Atiyah A., Ahmad H., Jones J., McGregor O., Ogundiya E., Boulbadaoui A., Kirnon-Jackman O., Lim Q.X., Peckham H., Yeoh T., Yong S.Q., Chen J.Y., Siva S., Sam Z.H., Gilani M., Goh Y.N., Muthukumar M.G., Phillips S., Tjoakarfa J., Giri A., Suresan S., Thomas P., Johnson T.A., Williams R.I., Rashid A., Kushairi A., Rais A., James A., Bugelli M., Chechelnitskaya Y., Sandhu N., Tandon R., Gray M., Kumar A., Ciurleo C., Nyamali I., Hiremath S., Sinha S., Chowdhary M., Bradley E., McTiernan M., Macdonald S., Sharkey S., McLaughlin N., Amey C., Kraria L., Skan O., Kind C., Tupper P., Van Rhee C., Honeyman S.I., Menon G., Jegatheeswaran L., Madhavan A., Warne M., Malcolm F.L., Lessware T., Wilkerson H.T., Chatterjee-Woolman S., Yoong A., Ahmed W.U.R., Longshaw A., Flannery O., Green R., Leaning M., Cragg J., Sharriff H., Doherty C., Kwan K.W.L., Sanders-Crook L., Bhatia S., Eames S., Lewis F., Kirupananthan P., Boh Z.Y., Dass S., Soma A., Newton A., Hill M., Shafiq Y., Brkljac M., Boyce L., English W.J., Lam S., Chipeta C., Jain C., Garofalidou T., Novotny S.A., Locke S., Bowman C., Begaj A., Murphy C., Radcliffe K., Chong J.T., Jeffrey E., Chaudhury N., Rajendran K., Akbar Z., Walters B., Kulendrarajah B., Tran N., Shrestha S., Parmar S., Gallagher C., Hennessy L., Pentti E., Badhrinarayanan S., Fung A., Mansoor M., Kenny R., Kan P., Lee D.E., Khosla S., Samake M., Shaban F., Aftab R., Gough M., Woodburn B., Vayalapra S., McMurrugh K., Jimulia D., Deol S., Pike S., Embury-Young Y., Patel M., Kilgallon E., Keating R., Walsh A., Khan H., Logue G., Orekoya M., Alasmar M., Charalambides M., Clave Llavall A., Williamson E., Bharwada Y., Zearmal S., Evans H., Panikkar M., de la Cruz G., Caplan J., Ruparelia A., Tanvir T., Soare C., Pang Y.L., Trotter J., Zaidi A., Thakrar V., Pulickal P., Ahmed H., Parnell J., Lennock S., Ford V., Brignall R., O'Neill D., Hanna R., Kane R., Nicola M., Rajput K., Xiao Y., Michael S., Wright E., Juniper S., Thompson E., Hoskyns L., Kanitkar A., Ross C., Unsworth A., Rshaidat H., Demarre K., Chiang A., Bareh A., van Dellen J., Faqihinejad C., Gadhvi A., Grant R., Lewsey J., Morris A., Martin H., McClarty C., Sanyal S., Alsaif A., Palkhi A., Bhopal S., Vishnu K S., Papanikolaou A., Mitra A., Nur A., Ali F., Burford C., Huq T., Irwin E., Matthews L., Ngu W.S., Hosfield T., Muneeb F., Page O., Zeb E., Al-Azzawi A., McIntosh J., Vucicevic A., Hughes M., Brooks L., Fanibi B., Dixon M., Njoku P., Morris D., Jobson J., Chowdhury H., Alawode D.O.T., Wynell-Mayow W., Udayachandran V., Alsoof D., Ekert J., Joseph N., Zulkefley N., Hunt G., Christodoulou T., Wright O., Soman S., Jamal M., Beqiri S., Borgas P., Christie S., Pereira F., Browne S., Yiu J., Dworkin A., Brayley J., Palmer A., Charalambos M., Jones C.S., Toner S., Cowden R., Lee L., Nicol P., Holman O., Imtiaz M., Albert V., Leung S.P., Erotocritou M., Stroud R., Wilkin R., Thomson W., Mackee L., G N., Bei Y., Mckenna Favier S., Ibrahim A., Kler A., Reynolds L., Mohamed S.H., Majeed Y., Fakim B., Jones A., Liversedge G., Carrington Z., Windebank J., Izzarina A., Akbani U., Craven J., Aldarragi A., Harding S., Millward A., Bedford M., Gopalan V., Midgen A., Khadka P., Cheng O., Taneja S., Manobharath N., Kok J.Y., Lim D.W.E., Buick T., Boland M., Piya S., Devlin R., Fairfield C.J., George R.J., Rahi M., Zaman S., Hajiev S., Ross T., Crisp E., Thompson C., Charalambous A., Hollywood J.L., Hammond R.F.L., 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Brandsma A.M., Davids J., Rottier S.J., de Roy van Zuidewijn D., Hawkins R., Ong H.I., Li Y., Desmond B., Winstanley J., Martins M., Americano M., Frade S., Senhorinho R., Peixoto R., Alves-Vale C., Lamas M., O'Connor D.B., Hoo M., Gopaul A., Scanlon K., O'Dwyer N., Jovanovic M., Panyko A., Van Vuuren S., Centeno A., Bernado I.R., Paniagua Garcia Senorans M., Gonzalez Amor L., Cuenca Ramirez A., Abrisqueta J., Estaire Gomez M., Arroyo A., Cerdan C., Gomez Romeu N., Enriquez-Navascues J.M., Collado-Roura F., Curchod P., Gaspar S., Imadalou L., Mutlu D., Akyol C., Uygur F.A., Eray I.C., Biyiklioglu O., Cetin M.F., Isik A.E., Karip B., Dogan H., Sarigul L., Tunc E., Aydin T., Bodur S., Karabulut K., Francis A.A., Al-hadithi A., To N., Lau I.S.F., Smith E., Mahapatra S., McAuliffe O., Imam L., Akram B., Hossaini S., Davies R., Ko M., Collins J., Pandya A., Reilly S., Archer J., Auty C., Roche C.D., Livie J., Chaudhry F.A., Ntakomyti E., Diallo R., Bylinski T., Wright J., Masiha E., Tung 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D., Hansmann, M., Medina Feliz, J., Kuiper, S. Z., Abdulrahman, Z., Pruijssers, S. R., Farik, S., Elliott, B. M., Geneta, V. P., Wilton, S., Kandelaki, H., Peng, S. L., Campbell, S., Lim, Y. K., Yassaie, S. S., Murray, M., Haran, C., Tan, J., Castro, J., Laranjeira, A., Catarino, S., Neves-Marques, C., Correia, J. G., Vieira, B. N., Quintela, A. C., Serra, M. L., Maciel, J., Cunha, M., Aparicio, D. J., Neves, J., Azevedo, J., Romano, M., Eiro, F., Romano, J., Monteiro, C., Claro, M., Almeida, M. R., Peyroteo, M., Machado, N. D., Capote, H., Ferreira, M., Sousa, X., Devesa, H., Cavadas, D., Guerreiro, I., Costa, M., Rosete, M., Salman, M., English, C., Mohammed, N., Litvin, A., Cuk, V. 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Pektas, A.M., Güner, B., İşlek, E.C., Tombul, H.B., Boztuğ, C.Y., Tınaz, A., Yılmaz, M., Akın, F.A., Başçavuş, M., Seker, M.C., Koçak, Z.B., Karapinar, Y.E., Köseoglu, E., Agca, M.H., Alim, Y.E., Kürklü, Ö., Çalar, S.N., Kavar, R.C., Cevlik, A.D., Turk, E.G., Erdönmez, H., Gürsoy, F., Önsal, U., Özbek, M., Kasar, P.A., Özen, D., Ölmez, M., Sariçiçek, T., Tipi, O.U., Benli, G.E., Bilgili, A.C., Kiraz, I.N., Demirci, Z.S., Aksoy, A.B., Karagöz, E., Tümer, S.S., Abdulrahman, S., Kuyumcu, O.F., Afsar, H.B., Guler, S.E., Gul, E.B., Dossa, S., Mizan, S.R., Mazlum, S.S., Sahin, A.Z., Kilinç, A., Yumurtaci, Ö., Girit, Ç., Yildirak, M.K., Güldag, A., Söyleyici, B., Aytin, Y.E., Akay, F.E., Iskan, N.G., Sunay, A.O., McGuckin, S., Delaugere, L.P., Yeo, Y.Q., Aly, M.H., Bin Amran, M.A., Kyaw, H.A., Clements, J.M., Wong, H.L., McCusker, C., Armitage, M.N., Hussain, A.S., Hassan Serry, M.Y., Tam, L., Sookramanien, S.R., Ward, K.L., Pherwani, S.A., Drury, D.J., James, S.J., Teasdale, A.B., Richardson, E., Thomas, D.A., Williams, R.L., Najabat-Lattif, H.F., Zhu, L.Y., Mihailidis, T.H., Pedersen, A.C., Robinson, A.V., Cheong, C.M., Ike, S.I., Chu, T., Mogg, J., Claireaux, H.A., Al-Ausi, M., Shah, S.M., Alame, Y.J., Owen, W.J., Ahsan, S.D., Adam, A.H., Parekh, J.N., Martin-Hernandez, M.P., Soh, Y.J., Rassool, S.B., McMillan, M., Ling, J.J., Howard, E.O., Wadsworth, O.J., Meney, L.C., Kang, C.K., Chiu, J., McGee, F., Tan, Q.J., Cross, G., McTighe, A., Shah, D.R., Ng, M., Wong, R., Rojoa, D.M., Ruddy, C.M., Hall, J.D., Hassane, A., Azhar, A.W., Tan, T.K., Kwak, S.Y., Ong, E.H., McGregor, O., Lim, Q.X., Yong, S.Q., Chen, J.Y., Sam, Z.H., Goh, Y.N., Muthukumar, M.G., Johnson, T.A., Williams, R.I., McTiernan, M., McLaughlin, N., Honeyman, S.I., Malcolm, F.L., Wilkerson, H.T., Ahmed, W., Kwan, K., Boh, Z.Y., English, W.J., Novotny, S.A., Chong, J.T., Lee, D.E., McMurrugh, K., Clavé Llavall, A., Pang, Y.L., McClarty, C., Ngu, W.S., McIntosh, J., Alawode, D., Jones, C.S., Leung, S.P., Mohamed, S.H., Kok, J.Y., Lim, D., Fairfield, C.J., George, R.J., Hollywood, J.L., Hammond, R., Flint, E.J., Lee, Y.D., Skalický, A., Ojakäär, A., Dörr-Harim, C., Cufari, M.E., Gusai, G.P., Di Mola Ospedale Ss Annunziata, F.F., Loche, G.A., Stellingwerf, M.E., van de Pas, K., Brandsma, A.M., Rottier, S.J., Ong, H.I., O'Connor, D.B., Jovanović, M., Bernado, I.R., Paniagua Garcia Señorans, M., González Amor, L., Cuenca Ramírez, A., Cerdán, C., Gómez Romeu, N., Enriquez-Navascues, J.M., Uygur, F.A., Eray, I.C., Çetin, M.F., Isik, A.E., Sarıgül, L., Francis, A.A., Al-Hadithi, A., Lau, I., McAuliffe, O., Roche, C.D., Chaudhry, F.A., Amsterdam Gastroenterology Endocrinology Metabolism, Other Research, Graduate School, Surgery, Oncology, AII - Infectious diseases, and ACS - Microcirculation more...
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medicine.medical_specialty ,endocrine system ,general surgery ,Gastrointestinal ,endocrine system diseases ,Settore MED/18 - CHIRURGIA GENERALE ,pulmonary complications ,03 medical and health sciences ,0302 clinical medicine ,Ileus ,Nasogastric tube insertion ,Medicine ,pulmonary complication ,pneumonia ,EPIDEMIOLOGY ,Humans ,Prospective Studies ,colorectal surgery ,nasogastric tube ,Prospective cohort study ,Intubation, Gastrointestinal ,OUTCOMES ,VENTILATOR-ASSOCIATED PNEUMONIA ,business.industry ,Elective Surgical Procedures ,Pneumonia ,Confounding ,Gastroenterology ,nutritional and metabolic diseases ,Odds ratio ,Postoperative pneumonia ,medicine.disease ,Colorectal surgery ,Surgery ,body regions ,Intubation, Gastrointestinal/adverse effects ,Pneumonia/epidemiology ,Pneumonia/etiology ,Pneumonia/prevention & control ,030220 oncology & carcinogenesis ,Vomiting ,030211 gastroenterology & hepatology ,medicine.symptom ,business ,Intubation ,hormones, hormone substitutes, and hormone antagonists - Abstract
© 2020 The Association of Coloproctology of Great Britain and IrelandAim: Aspiration is a common cause of pneumonia in patients with postoperative ileus. Insertion of a nasogastric tube (NGT) is often performed, but this can be distressing. The aim of this study was to determine whether the timing of NGT insertion after surgery (before versus after vomiting) was associated with reduced rates of pneumonia in patients undergoing elective colorectal surgery. Method: This was a preplanned secondary analysis of a multicentre, prospective cohort study. Patients undergoing elective colorectal surgery between January 2018 and April 2018 were eligible. Those receiving a NGT were divided into three groups, based on the timing of the insertion: routine NGT (inserted at the time of surgery), prophylactic NGT (inserted after surgery but before vomiting) and reactive NGT (inserted after surgery and after vomiting). The primary outcome was the development of pneumonia within 30 days of surgery, which was compared between the prophylactic and reactive NGT groups using multivariable regression analysis. Results: A total of 4715 patients were included in the analysis and 1536 (32.6%) received a NGT. These were classified as routine in 926 (60.3%), reactive in 461 (30.0%) and prophylactic in 149 (9.7%). Two hundred patients (4.2%) developed pneumonia (no NGT 2.7%; routine NGT 5.2%; reactive NGT 10.6%; prophylactic NGT 11.4%). After adjustment for confounding factors, no significant difference in pneumonia rates was detected between the prophylactic and reactive NGT groups (odds ratio 1.03, 95% CI 0.56–1.87, P = 0.932). Conclusion: In patients who required the insertion of a NGT after surgery, prophylactic insertion was not associated with fewer cases of pneumonia within 30 days of surgery compared with reactive insertion. more...
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- 2020
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20. Safety and efficacy of non-steroidal anti-inflammatory drugs to reduce ileus after colorectal surgery
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Chapman, Sj, Clerc, D, Blanco‐colino, R, Otto, A, Nepogodiev, D, Pagano, G, Schaeff, V, Soares, A, Zaffaroni, G, Žebrák, R, Hodson, J, Glasbey, Jc, Pata, P, Pellino, G, Sgrò, A, Elst, T, Van Straten, S, Knowles, Ch, Borakati, A, Bath, Mf, Yasin, Ih, Mclean, K, Arthur, T, Kovacevic, M, Delibegovic, S, Karamanliev, M, Swamad, M, Paramasivam, R, Martensen, A, Larsen, Hm, Rädeker, L, Frey, Pe, Kechagias, A, Venara, A, Duchalais, E, Ioannidis, A, Pata, F, Pasquali, S, Simioni, A, Farina, V, Podda, M, Lorenzon, L, Jakubauskas, M, Elst, Tr, Chu, M, Fagan, Pvb, Wells, Ci, Alagoa João, A, Juloski, J, Ciubotaru, C, Popescu, S, Yanishev, A, Lee, S, Ozkan, Bb, Yagız Sen, A, Aktas, Mk, Baki, Be, Yüksek, B, Kamarajah, S, Khaw, Ra, Mills, E, Goodson, R, Thakral, N, Ablett, Ad, Adra, M, Kwek, I, Khan, Sm, Quinn, P, Manley, Lr, Badran, A, Ramjeeawon, A, Campbell, A, Tan, Hl, Rye, Ds, Rajaraman, N, Norman, Jg, Vutipongsatorn, K, Solomou, G, Akhbari, M, Ali, A, Murray, V, Baker, Dm, Brandao, Bd, Stainer, 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al-Ausi M., Jovaisaite A., Shah S.M., Khalid N., Gutmann D., Davison S., Alame Y.J., Syed L., Owen W.J., Ahsan S.D., Anthony-Uzoeto U., Macleod Hall C., Zheng S., Wynter K., James C., Sapre D., Ghosh R., Baird J., Cockburn L., Blackwood O., Simpson W., Jeong S., Bishop S., Bate R., Hobson C., Adam A.H., Redclift C., Do J., Adeleye O., Poli F., Batterham A., Brown S., Parekh J.N., Clay W., Pieri K., Jackson A., Saxena A., Gurung B., Oyebola T., O'Brien F., Djeugam B., Gardezi S., Ul-Hasan S., Martin-Hernandez M.P., Sisley M., Modi S., Antakia R., Elbayouk A., Soh Y.J., Mather J., Yusuf Z., Al-Sarraf Z., Naja M., Rassool S.B., Convill J., Nikookam Y., Warsame A., Pace C., Kiandee M., Ridwan R., Carey C., Hirri F., McMillan M.J.A., Ling J.J., Pendelbury L., Kerimzade K., Tang A., Howard E.O., Humayun S., Wadsworth O.J., Tan K., Abdelhameed F., Haglund C., Radnaeva I., Hu N., Rambhatla S., Waldron D., Madahar P., Malik S., Meney L.C., Ibrahim I., Kang C.K., Chiu J.Z.J., Livie V., Ibrahim 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Q.X., Peckham H., Yeoh T., Yong S.Q., Chen J.Y., Siva S., Sam Z.H., Gilani M., Goh Y.N., Muthukumar M.G., Phillips S., Tjoakarfa J., Giri A., Suresan S., Thomas P., Johnson T.A., Williams R.I., Rashid A., Kushairi A., Rais A., James A., Bugelli M., Chechelnitskaya Y., Sandhu N., Tandon R., Gray M., Kumar A., Ciurleo C., Nyamali I., Hiremath S., Sinha S., Chowdhary M., Bradley E., McTiernan M., Macdonald S., Sharkey S., McLaughlin N., Amey C., Kraria L., Skan O., Kind C., Tupper P., Van Rhee C., Honeyman S.I., Menon G., Jegatheeswaran L., Madhavan A., Warne M., Malcolm F.L., Lessware T., Wilkerson H.T., Chatterjee-Woolman S., Yoong A., Ahmed W.U.R., Longshaw A., Flannery O., Green R., Leaning M., Cragg J., Sharriff H., Doherty C., Kwan K.W.L., Sanders-Crook L., Bhatia S., Eames S., Lewis F., Kirupananthan P., Boh Z.Y., Dass S., Soma A., Newton A., Hill M., Shafiq Y., Brkljac M., Boyce L., English W.J., Lam S., Chipeta C., Jain C., Garofalidou T., Novotny S.A., Locke S., Bowman C., Begaj A., Murphy C., Radcliffe K., Chong J.T., Jeffrey E., Chaudhury N., Rajendran K., Akbar Z., Walters B., Kulendrarajah B., Tran N., Shrestha S., Parmar S., Gallagher C., Hennessy L., Pentti E., Badhrinarayanan S., Fung A., Mansoor M., Kenny R., Kan P., Lee D.E., Khosla S., Samake M., Shaban F., Aftab R., Gough M., Woodburn B., Vayalapra S., McMurrugh K., Jimulia D., Deol S., Pike S., Embury-Young Y., Patel M., Kilgallon E., Keating R., Walsh A., Khan H., Logue G., Orekoya M., Alasmar M., Charalambides M., Clave Llavall A., Williamson E., Bharwada Y., Zearmal S., Evans H., Panikkar M., de la Cruz G., Caplan J., Ruparelia A., Tanvir T., Soare C., Pang Y.L., Trotter J., Zaidi A., Thakrar V., Pulickal P., Ahmed H., Parnell J., Lennock S., Ford V., Brignall R., O'Neill D., Hanna R., Kane R., Nicola M., Rajput K., Xiao Y., Michael S., Wright E., Juniper S., Thompson E., Hoskyns L., Kanitkar A., Ross C., Unsworth A., Rshaidat H., Demarre K., Chiang A., Bareh A., van Dellen J., Faqihinejad C., Gadhvi A., Grant R., Lewsey J., Morris A., Martin H., McClarty C., Sanyal S., Alsaif A., Palkhi A., Bhopal S., Vishnu K S., Papanikolaou A., Mitra A., Nur A., Ali F., Burford C., Huq T., Irwin E., Matthews L., Ngu W.S., Hosfield T., Muneeb F., Page O., Zeb E., Al-Azzawi A., McIntosh J., Vucicevic A., Hughes M., Brooks L., Fanibi B., Dixon M., Njoku P., Morris D., Jobson J., Chowdhury H., Alawode D.O.T., Wynell-Mayow W., Udayachandran V., Alsoof D., Ekert J., Joseph N., Zulkefley N., Hunt G., Christodoulou T., Wright O., Soman S., Jamal M., Beqiri S., Borgas P., Christie S., Pereira F., Browne S., Yiu J., Dworkin A., Brayley J., Palmer A., Charalambos M., Jones C.J., Toner S., Cowden R., Lee L., Nicol P., Holman O., Imtiaz M., Albert V., Leung S.P., Erotocritou M., Stroud R., Wilkin R., Thomson W., Mackee L., G N., Bei Y., Mckenna Favier S., Ibrahim A., Kler A., Reynolds L., Mohamed S.H., Majeed Y., Fakim B., Jones A., Liversedge G., Carrington Z., Windebank J., Izzarina A., Akbani U., Craven J., Aldarragi A., Harding S., Millward A., Bedford M., Gopalan V., Midgen A., Khadka P., Cheng O., Taneja S., Manobharath N., Kok J.Y., Lim D.W.E., Buick T., Boland M., Piya S., Devlin R., Fairfield C.J., George R.J., Rahi M., Zaman S., Hajiev S., Ross T., Crisp E., Thompson C., Charalambous A., Hollywood J.L., Hammond R.F.L., Matthews J., Mendonca V., Spinty J., Khan K., Cheng J., Glynn N., Muhammad U., Khan M., Anderson L., Mccormack K., Mak J., Patrawala S., Milinkovic N., Schofield R., Chauhan M., Hartley L., Hind J., Nelson L., Ratnasingham D., Whitehead T., Dimitriadis S., Marshall K., Flint E.J., Horner C., Heybourne A., Morgan H., Wickstone C., Panagiotou D., O'Connell E., Dean K., Iqbal R., Walsh L., Yu N., Rana N., Massie E., Ng J., Jung M., Lee Y.D., Harris M., White S., Boev B., Tonchev P., Prochazka V., Skalicky A., Ravn S., Ojakaar A., Dorr-Harim C., Koutserimpas C., Giraudo G., Armellini A., Ruzzenente A., Mazzeo C., De Padua C., Realis Luc A., Maroli A., Giani I., Cufari M.E., Vitali M., Gusai G.P., Quattromani R., Virgilio E., Berti S., Di Mola F.F., Papagni V., Tuminello F., Vittori L., Longheu A., Loche G.A., Braccio B., De Luca E., Resta G., Ancans G., Tamosiunas A., Petrulionis M., Andrejevic P., Stellingwerf M.E., Abdulrahman N., van de Pas K.G.H., Thomas G., Brandsma A.M., Davids J., Rottier S.J., de Roy van Zuidewijn D., Hawkins R., Ong H.I., Li Y., Desmond B., Winstanley J., Martins M., Americano M., Frade S., Senhorinho R., Peixoto R., Alves-Vale C., Lamas M., O'Connor D.B., Hoo M., Gopaul A., Scanlon K., O'Dwyer N., Jovanovic M., Panyko A., Van Vuuren S., Curchod P., Gaspar S., Imadalou L., Mutlu D., Akyol C., Uygur F.A., Eray I.C., Biyiklioglu O., Cetin M.F., Isik A.E., Karip B., Dogan H., Sarigul L., Tunc E., Aydin T., Bodur S., Karabulut K., Francis A.A., Al-hadithi A., To N., Lau I.S.F., Smith E., Mahapatra S., McAuliffe O., Imam L., Akram B., Hossaini S., Davies R., Ko M., Collins J., Pandya A., Reilly S., Archer J., Auty C., Roche C.D., Livie J., Chaudhry F.A., Ntakomyti E., Diallo R., Bylinski T., Wright J., Masiha E., Tung J., Shirazi B., Neilson A., Epton S., Patel N., Trussell S., Couldrey A., Donnelly C., Eftychiou S., Chapman, S. 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Geçim, Ie, Disçi, E, Haksal, Mc, Agarwal, T, Maxwell‐armstrong, C, Moug, Sj, Lund, Jn, Smart, Nj, Smith, Fm, Lee, Yj, Lai, Lt, Jun, Hj, Mendis, Dm, Robb, Pm, Lee, Hj, Wyche, Aab, Davis, Lt, Jayalath, Jmsn, Blefari, Nda, Goh, Yk, Beh, Yz, Dudi‐venkata, Nn, Borrow, Jl, Chua, Th, Tan, Rr, Ng, Sy, Britten‐jones, P, Pham, Hdv, Coulter‐nile, Smcj, Gosselink, Mp, Wang, Yl, Pös, M, Bartoš, M, Malý, O, Hanušová, M, Hurný, M, Riško, J, Treskoň, R, Pospíšil, M, Hlaváčová, L, Tomanová, D, Novický, R, Sobotková, K, šuta Kimle, K, Paclík, A, Jürgens‐lahnstein, J, Kristensen, Fp, Bønnerup, K, Højgaard Pedersen, J, Jepsen, Bn, Hillgaard, Tk, Erichsen, Sb, Nielsen, Cv, Madsen, Cp, Skejø, Cd, Aabling, Rr, Sørensen, J, Schöning, L, Simon, S CS, Thäwel, T, Seckler, Am, Athanasopoulos, Pg, Giuffrida, Mc, Billo, Me, Marrosu, Ag, Ruggiu, Mw, Antona, Ad, Bitonti, Mf, Romano, Fm, Pellicanò, Ga, Murru, Ml, Angelucci, Gp, Tenconi, Sm, Mura, Fa, Ruggiu, Gv, Mura, Ga, Perrone, Ba, Esposito, Lm, Marcianò, M, Aru, 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Pc, Jardim, Jam, Domingos, Sp, Baião, Jm, Lopes, Nmro, Jordão, Dm, Ângelo, Md, Caroço, T, Gomes, Jr, Monteiro, Rg, Colon, Lf, Dockry, É, Aly, Ak, Kang, Sj, Pentony, Ar, Piong, Cl, Eow, Sy, Kamath, Pj, Soh, Tbw, Dyer, Ah, Chee, Sy, Tan, Ixh, Jones, Mr, Al‐salihi, A, Ciubotaru, Ci, Radulović, R, Miloševic, K, Bojičić, J, Genčić, M, Janković, U, Sucháň, Pk, Dubovský, M, Sautter, Sc, Mcduling, Cr, Haller, Ml, Piotet, Lm, Kurtoglu, Gk, Sel, Ek, Isler, Vc, Demirkaya, Hc, Korkmaz, Hk, Pektas, Am, Güner, B, İşlek, Ec, Tombul, Hb, Boztuğ, Cy, Tınaz, A, Yılmaz, M, Akın, Fa, Başçavuş, M, Seker, Mc, Koçak, Zb, Karapinar, Ye, Köseoglu, E, Agca, Mh, Alim, Ye, Kürklü, Ö, Çalar, Sn, Kavar, Rc, Cevlik, Ad, Turk, Eg, Erdönmez, H, Gürsoy, F, Önsal, U, Özbek, M, Kasar, Pa, Özen, D, Ölmez, M, Sariçiçek, T, Tipi, Ou, Benli, Ge, Bilgili, Ac, Kiraz, In, Aksoy, Ab, Karagöz, E, Tümer, S, Abdulrahman, Smf, Kuyumcu, Of, Afsar, Hb, Guler, Se, Gul, Eb, Dossa, Saa, Mizan, Sr, Sahin, Az, Kilinç, A, Yumurtaci, Ö, 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Zh, Goh, Yn, Muthukumar, Mg, Johnson, Ta, Williams, Ri, Honeyman, Si, Malcolm, Fl, Wilkerson, Ht, Chatterjee‐woolman, S, Ahmed, Wur, Kwan, Kwl, Sanders‐crook, L, Boh, Zy, English, Wj, Novotny, Sa, Chong, Jt, Lee, De, Embury‐young, Y, Clavé Llavall, A, Pang, Yl, Dellen, J, Al‐azzawi, A, Alawode, Dot, Wynell‐mayow, W, Christodoulou, T, Jones, Cj, Leung, Sp, Mohamed, Sh, Kok, Jy, Lim, Dwe, Fairfield, Cj, George, Rj, Hollywood, Jl, Hammond, Rfl, Flint, Ej, Lee, Yd, Skalický, A, Ojakäär, A, Dörr‐harim, C, Cufari, Me, Gusai, Gp, Di Mola, Ff, Loche, Ga, Stellingwerf, Me, Pas, Kgh, Brandsma, Am, Rottier, Sj, Roy van Zuidewijn, D, Ong, Hi, Alves‐vale, C, O'Connor, Db, Jovanović, M, Uygur, Fa, Eray, Ic, Çetin, Mf, Isik, Ae, Sarıgül, L, Francis, Aa, Al‐hadithi, A, Lau, Isf, Roche, Cd, and Chaudhry, Fa more...
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Male ,renal failure ,Time Factors ,medicine.medical_treatment ,Adult ,Aged ,Anti-Inflammatory Agents, Non-Steroidal ,Elective Surgical Procedures ,Female ,Humans ,Ileus ,Kaplan-Meier Estimate ,Middle Aged ,Patient Safety ,Postoperative Care ,Postoperative Complications ,Proportional Hazards Models ,Prospective Studies ,Recovery of Function ,Treatment Outcome ,Colectomy ,Proctectomy ,Anti-Inflammatory Agents ,colorectal surgery ,ileus ,non-steroidal anti-inflammatory drugs ,NSAIDS ,030230 surgery ,Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] ,0302 clinical medicine ,Prospective cohort study ,Colorectal ,RISK ,Hazard ratio ,Acute kidney injury ,Colorectal surgery ,NSAID ,030220 oncology & carcinogenesis ,Non-Steroidal ,Cohort study ,colorectal Surgery, ileus, non-steroidal anti-inflammatory drugs ,medicine.medical_specialty ,Non‐steroidal anti‐inflammatory drugs. NSAIDs. Postoperative ileus. Colorectal surgery ,ACUTE KIDNEY INJURY ,anti-inflammatory agents ,03 medical and health sciences ,Internal medicine ,medicine ,Adverse effect ,non-steroidal anti-inflammatory drugs - ileus - colorectal surgery ,business.industry ,medicine.disease ,Settore MED/18 - Chirurgia Generale ,colorectal cancer ,Surgery ,business - Abstract
Ileus is common after elective colorectal surgery, and is associated with increased adverse events and prolonged hospital stay. The aim was to assess the role of non-steroidal anti-inflammatory drugs (NSAIDs) for reducing ileus after surgery.A prospective multicentre cohort study was delivered by an international, student- and trainee-led collaborative group. Adult patients undergoing elective colorectal resection between January and April 2018 were included. The primary outcome was time to gastrointestinal recovery, measured using a composite measure of bowel function and tolerance to oral intake. The impact of NSAIDs was explored using Cox regression analyses, including the results of a centre-specific survey of compliance to enhanced recovery principles. Secondary safety outcomes included anastomotic leak rate and acute kidney injury.A total of 4164 patients were included, with a median age of 68 (i.q.r. 57-75) years (54·9 per cent men). Some 1153 (27·7 per cent) received NSAIDs on postoperative days 1-3, of whom 1061 (92·0 per cent) received non-selective cyclo-oxygenase inhibitors. After adjustment for baseline differences, the mean time to gastrointestinal recovery did not differ significantly between patients who received NSAIDs and those who did not (4·6 versus 4·8 days; hazard ratio 1·04, 95 per cent c.i. 0·96 to 1·12; P = 0·360). There were no significant differences in anastomotic leak rate (5·4 versus 4·6 per cent; P = 0·349) or acute kidney injury (14·3 versus 13·8 per cent; P = 0·666) between the groups. Significantly fewer patients receiving NSAIDs required strong opioid analgesia (35·3 versus 56·7 per cent; P 0·001).NSAIDs did not reduce the time for gastrointestinal recovery after colorectal surgery, but they were safe and associated with reduced postoperative opioid requirement.El ileo es frecuente tras cirugía colorrectal electiva y se asocia con un incremento de los eventos adversos y de la duración de la estancia hospitalaria. El objetivo fue evaluar el papel de los fármacos antiinflamatorios no esteroideos (non-steroidal anti-inflammatory drugs, NSAIDs) para reducir el ileo tras la cirugía. MÉTODOS: Estudio de cohortes prospectivo y multicéntrico efecuado por un grupo colaborativo dirigido por estudiantes y cirujanos en formación. Se incluyeron pacientes adultos sometidos a cirugía colorectal electiva entre enero y abril 2018. El resultado primario fue el tiempo hasta la recuperaciòn gastrointestinal, medido por una variable compuesta de función intestinal y tolerancia a la alimentación oral. El impacto de los NSAIDs se exploró utilizando un análisis de regresión de Cox, que incluía los resultados de una encuesta específica dirigida a los centros sobre la adherencia a los principios de la recuperación intensificada. Los resultados secundarios de seguridad incluyeron la dehiscencia anastomótica y la insuficiencia renal aguda.Se incluyeron 4.164 pacientes con una mediana de edad de 68 años (rango intercuartílico: 57-75; 54,9% varones). Un total de 1.153 (27,7%) pacientes fueron tratados con NSAIDs en los días postoperarorios 1-3, de los cuales 1.061 (92,0%) recibieron inhibidores no selectivos de la ciclooxigenasa. Tras los ajustes por las diferencias basales, el tiempo medio hasta la recuperación gastrointestinal no difería significativamente entre pacientes que recibieron o no recibieron NSAIDs (4,6 versus 4,8 días; cociente de riesgos instantáneos, hazard ratio, HR 1,04, i.c. del 95%: 0,96-1,12, P = 0,360). No hubo diferencias significativas en la tasa de dehiscencias anastomóticas (5,4% versus 4,6%; P = 0,349) o insuficiencia renal aguda (14,3% versus 13,8%; P = 0,666) entre los grupos. Sin embargo, significativamente menos pacientes de los que recibieron NSAIDs precisaron una analgesia intensa con opioides (35,3% versus 56,7%; P 0,001). CONCLUSIÓN: La administración de NSAIDs no redujo el tiempo hasta la recuperación gastrointestinal tras cirugía colorrectal, pero fueron seguros y se asociaron con una reducción en la necesidad de opioides postoperarorios. more...
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- 2019
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21. P-1 Health-related quality of life of rectal cancer survivors treated with curative intent
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Ferreira, A., primary, Sardinha, M., additional, Baleiras, M., additional, Neves, M., additional, Matos, A., additional, Malheiro, M., additional, Dutra, E., additional, Rodrigues, C., additional, Miguens, M., additional, Guerreiro, I., additional, da Luz, R., additional, and Martins, A., additional more...
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- 2021
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22. P-351 Colon cancer in young patients – real-world data from a single center review
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Montenegro, M., Spencer, A., Leão, J., Furtado, I., Ferreira, R., Escaleira, R., Verdasca, F., Seladas, M., Fernandes, V., Gil, L., Ferreira, J., Guerreiro, I., and Luz, R.
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- 2023
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23. Influence of nanoencapsulation on the sensory properties of cosmetic formulations containing lipoic acid
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Külkamp-Guerreiro, I. C., Berlitz, S. J., Contri, R. V., Alves, L. R., Henrique, E. G., Barreiros, V. R. M., and Guterres, S. S.
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- 2013
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24. Hepatic intermediary metabolism of rainbow trout fed commercial diets including increasing levels of a partially defatted yellow mealworm meal
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Chemello, G., Renna, M., Caimi, C., Guerreiro, I., Oliva-Teles, A., Enes, P., Biasato, I., Lussiana, C., Malfatto, V., Schiavone, A., Gai, F., and Gasco, L.
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- 2020
25. Timing of nasogastric tube insertion and the risk of postoperative pneumonia: an international, prospective cohort study
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Glasbey, J. C., Bibi, S., Pata, F., Ozkan, B. B., Van Straten, S., Hodson, J., Chapman, S. J., Blanco-Colino, R., Pellino, G., Sgro, A., Soares, A., van Elst, T., Nepogodiev, D., Borakati, A., Bath, M. F., Yasin, I. H., Mclean, K., Arthur, T., Kovacevic, M., Delibegovic, S., Karamanliev, M., Swamad, M., Zebrak, R., Paramasivam, R., Martensen, A., Larsen, H. M., Radeker, L., Frey, P. E., Kechagias, A., Venara, A., Duchalais, E., Ioannidis, A., Pasquali, S., Simioni, A., Farina, V., Podda, M., Lorenzon, L., Itsurg, I., Schaeff, V., Otto, A., Jakubauskas, M., van Elst, T. R., Chu, M., Fagan, P. V. B., Wells, C. I., Alagoa Joao, A., Juloski, J., Perez-Ajates, S., Anabitarte Bautista, O., El Kasmy, Y., Espin-Basany, E., Clerc, D., Ciubotaru, C., Popescu, S., Yanishev, A., Lee, S., Yagiz Sen, A., Aktas, M. K., Baki, B. E., Yuksek, B., Kamarajah, S., Khaw, R. A., Mills, E., Goodson, R., Thakral, N., Collaborative, S., Ablett, A. D., Adra, M., Kwek, I., Khan, S. M., Quinn, P., Manley, L. R., Badran, A., Ramjeeawon, A., Campbell, A., Tan, H. L., Rye, D. S., Rajaraman, N., Norman, J. G., Vutipongsatorn, K., Solomou, G., Akhbari, M., Ali, A., Murray, V., Baker, D. M., Brandao, B. D., Stainer, B., Thavayogan, R., Jones, D., Onafowokan, O. O., Gharooni, A., Dabab, N., Carlton-Carew, S., Kungwengwe, G., Gabriel, M., Sewart, E., Shortland, T. C., Lawday, S., Pockney, P., Dawson, A., Brumfitt, C. D., Stewart, P., Ng, B., Luong, J. K., Ivanov, V., Borisova, A., Neykov, V., Kuncarova, K., Kolosova, B., Antonova, T., Farkasova, M., Harbjerg, J. L., Brandsborg, S., Brinck, S., Kjaer, M. D., Mark-Christensen, A., Unbehaun, K. P., Dalsgaard, P., Lycke, K. D., Lenaoures, P., Brigand, C., Dumange, E., Gout, M., Moehwald, C., Prem, M., Alhalabi, O., Sliwinski, S., Krupp, J., Gablenz, E., Schmitzer, L., Kopp, A., Steinle, J., Gsenger, J., Pohl, L. J., Riccardi, M., Christodoulou, I. M., Konstantinidis, M., Machairas, N., Zoikas, A., Balalis, D., Manatakis, D. K., Aguilera, M. L., Marano, L., Fleres, F., Lovisetto, F., Sasia, D., Segalini, E., Pata, G., Lucchi, A., Sagnotta, A., Campagnaro, T., Petrelli, F., Gallo, G., Papandrea, M., Testa, V., Sinibaldi, G., Di Candido, F., Colombo, F., Perrone, G., Biancafarina, A., Canonico, G., Pagnanelli, M., Curletti, G., Bini, R., de Manzoni Garberini, A., Impellizzeri, H., Cillara, N., Tutino, R., Picciariello, A., Coletta, D., Savino, G., Ferrara, F., Tamini, N., Talamo, G., Parini, D., Giamundo, P., lo Conte, A., Pagano, G., Ripetti, V., Pesce, A., Menduni, N., Giudicissi, R., Goldin, E., Rega, D., Belli, A., Andriola, V., Gordini, L., Foppa, C., Piccolo, G., Birindelli, A., Ferrari, C., Ballarini, Z., Tirelli, F., Milone, M., De Rosa, M., Pipitone Federico, N. S., Molteni, B., Tilocca, P. L., Sancini, G., Piozzi, G. N., Lauretta, A., Poillucci, G., Mulas, S., Simcikas, D., Portelli, L., van Wijnbergen, J. W. M., Dinger, T. L., ten Doesschate, S. F. H., van Dalen, A. S. H. M., van den Bos, D. 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V., Meszarosova, K., Jaich, R., De Lima, H., Brooks, S., Marx, M., Nshalati Salvation, M., Garcia Cardo, J., Mora-Guzman, I., Sancho Muriel, J., de Andres Olabarria, U., Muriel, P., Jimenez Vinas, C., Alconchel, F., Esteban Sinovas, O., Gomez del Pulgar, A., Fairen Oro, C., Lopez Otero, M., Figueroa Jimenez, S., Claramonte Bellmunt, O., Martinez Caballero, J., Rubio-Perez, I., Aguilar-Martinez, M. M., Segura-Sampedro, J. J., Olmedo Moreno, C., Negre Parra, D., Estevez Diz, A. M., Martin-Balbuena, R., Bustamante Recuenco, C., Licardie Bolanos, R. E., Fernandez, P., Diaz Padillo, A., Forero-Torres, A., Alberdi San Roman, I., Salvador Roses, H., Merayo Alvarez, M., Villarejo Campos, P., Lopes Moreira, C. C., Uriol Peralta, P., Serrano Navidad, M., Ripolles-Melchor, J., Garcea, A., Gomez Facundo, H., Troncoso Pereira, P., V Perez Guarinos, C., Blaser, B., Piazza, G., Gagliardi, B., Serin, H., Yurdaor, S. S., Arslan, E., Kopac, O., Uyanik, A., Ozmen, B. B., Tiftik, E., Aksoy, B., Yalcinkaya, A., Ozoglu, F., Kocer, M. D., Bilicen, G., Cinar, E. N., Uslu, O., Kaya, Y., Demirci, K., Wong, J., Farhan-Alanie, M. M. H., Suresh, G., Asif, A., Finch, B. J., Bhahirathan, Y., Herron, J., Yi Tew, Z., Obukofe, R., Russell, C., Suchett-Kay, I., Netke, T., Williams, L., Kisiel, A., Liu, F. Y., Claireaux, H., James, P., Mondal, A., Kalderon, R., Nadama, H. H., Al-Saraff, Z., Tam, J. P. H., Powell-Chandler, A., Wood, F., Gorgievska, R., Ragavoodoo, A., Thakrar, C., Rojoa, D., Palmer, C., Davidson, K., Giacci, L., Hale, J., Gan, F. W., Makin-Taylor, R., Hey, C. Y., Toh, C., Findlay, J. 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I., Ortega, J., Vivas Angeles, P., Vives Figueras, R., Baena Sanfeliu, E., Campillo Alonso, B., Alberich Prats, M., Duran Arrocha, J., Cornella Garceso, N., Uribe Galeano, C., Delisau Puig, O., Castro, A., Codony Bassols, C., Fernandes, N., Garcia Adamez, J., Caula Freixa, C., Sanchez, M. J., Martin-Borregon, P., Quevedo, A., Martinez, J., Marin, J. M., Rodriguez, P., Garcia Orozco, J. J., Ferrusola Diaz, D. A., Garcia Jimenez, M. L., Castro Diez, L., Mosquera Fernandez, C., Alonso Batanero, E., Cifrian Canales, I., Calzada, M. G., Recuenco, C. B., Martin, M. C., Esteban Avendano, I., Jimenez Relimpio, C., Lancho Lavilla, P., Blanco Bartolome, I., Gomez Cano, I., Blasco Andres, C., Alonso-Poza, A., Dieguez, B., Losada, M., Gilsanz, C., Garcia-Vico, A., Roman-Rando, A., Sanchez-Galvez, M. A., Bersabe-Alonso, I. M., Vadillo-Bohorquez, A., Gutierrez Rios, R. D., Eizaguirre Ubegun, M., Novo Sukia, I., Uribe Isado, M., Ibanez Alda, M., Pastor Idoate, C., Abad-Motos, A., Marinez-Hurtado, E., Salvachua-Fernandez, R., Padilla Zegarra, E. D., Franco, M., Martinez, A., Ramos Martin, P., Mate Mate, P., Marcano Chavez, C., Ayllon, H., Jeri-McFarlane, S., Soldevila-Verdeguer, C., Pineno-Flores, C., Ambrona-Zafra, D., Fernandez-Vega, L., Gil-Catalan, A., Craus-Miguel, A., Pujol-Cano, N., Sena-Ruiz, F., Gomez Jurado, M. J., Alberti Delgado, P., Bordanova Reverter, A., Belzunce-Capo, J. F., Verdaguer Tremolosa, M., Lin, Q., Muniesa, C., Avelino, L., Cholewa, H., Sancho-Muriel, J., Navasquillo, M., Navio, A., Abello, D., De Jesus, M., Alvarez, E., Garcia, J. M., Gil, A., Giordano, H. E., Mignon, G., Vanoni, A., Henkens, A., Jarrar, G., Odovic, M., Willemin, M., Milliet, O., Hahnloser, D., Demartines, N., Teixeira, H., Pittet, O., Haller, M. L., Huot, A., Kefleyesus, A., Bugmann, A., Piotet, L. M., Meijers, L., Kurtoglu, G. K., Sel, E. K., Isler, V. C., Yilmaz, B. S., Adiyaman, C., Kara, M., Demirkaya, H. C., Korkmaz, H. K., Pektas, A. M., Guner, B., Islek, E. C., Tombul, H. B., Boztug, C. Y., Tinaz, A., Yilmaz, M., Karaman, Y., Akin, F. A., Dansuk, S., Bascavus, M., Kaya, M., Kutlu, B., Seker, M. C., Erten, V., Memis, U., Kocak, Z. B., Karapinar, Y. E., Fakirullahoglu, M., Koseoglu, E., Yeni, M., Aykun, N., Agca, M. H., Bilen, C., Kilinc, I., Atar, C., Kilic, V., Aktuna, C., Aba, M., Alim, Y. E., Binbuga, M., Kurklu, O., Ceylan, C., Yilmaz, S., Calar, S. N., Yildirim, N., Yavuz, G., Can, B., Cesmeli, E., Kus, D., Kavar, R. C., Cevlik, A. D., Cengiz, U., Turk, E. G., Yilmaz, I., Erdonmez, H., Gursoy, F., Kara, H., Onsal, U., Ozbek, M., Kasar, P. A., Ipor, A., Ozen, D., Olmez, M., Altintas, E., Toklu, R., Saricicek, T., Tipi, O. U., Benli, G. E., Tasdelen, I., Tura, A., Ucar, A., Ekci, B., Bilgili, A. C., Kiraz, I. N., Aksoy, H., Basak, A., Erdem, M., Kayacan, S., Sahin, C., Uysal, M., Karakus, K., Altiner, S., Demirci, Z. S., Eren, E., Yavas, M., Aksoy, A. B., Karagoz, E., Sabanci, R., Tumer, S. S., Kargici, K., Banaz, T., Abdulrahman, S. M. F., Yesilsancak, M., Yanikoglu, E., Karabulut, A., Yilmaz, D., Kuyumcu, O. F., Kutluk, F., Emiroglu, B., Mollavelioglu, B., Gereklioglu, D., Guler, M., Toprak, S., Afsar, H. B., Guler, S. E., Alizade, E., Alemdag, G., Ulusahin, M., Gul, E. B., Yildirim, R., Semiz, A., Bektur, G., Tomas, K., Yarenci, E., Demiroglu, Y., Sunal, A., Baykan, B., Abbasguliyev, H., Mutlu, V., Mahmoudi, Y., Dossa, S. A. A., Mizan, S. R., Demirtas, B., Cavus, T., Yuksek, A., Mazlum, S. S., Yelkenci, C., Baran, T., Satilmisoglu, M., Sahin, A. Z., Kilinc, A., Isik, K., Yumurtaci, O., Emin, A., Girit, C., Yildirak, M. K., Senyigit, E., Guldag, A., Soyleyici, B., Aytin, Y. E., Akay, F. E., Iskan, N. G., Mutlu, B., Sunay, A. O., Tie-Gill, T., Ramsay, G., De Paola, L., Mcguckin, S., Alshakhs, A., Ahmeidat, A., Goergen, N., Ali, Z., Mullarkey, L., Walshe, R., Lewis, E., Berry, B., Moneim, J., Mookerjee, S., Christy, S., Ojofeitimi, O., Carroll, L., Hylands, A., Delaugere, L. P., Reveendran, D., Coulter, C., Ralston, C., Laverty, L., Gallagher, P., Ahmed, A., Yeo, Y. Q., Elliott, D., Bennett, J., Mcnamara, M., Sivarajah, S., Dunmore, C., Aitken, G., Nair, M., Aly, M. H., Buari, M., Ahmed, K., Sheikh, Z., Monks, M., Lehmann, J., Rotimi, O., Bell, T., Limnatitou, D., Gormley, S., Taleongpong, P., Patel, V., Macgregor, L., Amini, S., Turner, C., Dwyer-Hemmings, L., Busuttil, A., Powell, J., Hensher, C., Vivian, F., Wcislo, K., Millar, Z., Hirosue, S., Ogunmwonyi, I., Nakakande, D., Gaze, H., Nirmalanantha, A., Bin Amran, M. A., Foulkes, A., Jones, N., Pillai, S., Khoury, G., Powell, T., Maleyko, I., Sangheli, A., Ransome, M., Isse, M., Aromolaran, O., Bholah, H., Anbarasan, J., Rehman, S., Hu, E., Timms, S., Reynolds, W., Hotchkies, A., Misra, V., Theocharidou, L., Malik, T., Janmohamed, I., Carhart, B., Khan, A., Hullait, R., Rylance, A., Butt, S., Leathes, J., Philip Rajathasan, T., Jeddy, H., Kyaw, H. A., Wong, N., Karelia, S., Clements, J. M., Rainey, M., Joshi, N., Rahman, A., Gallagher, M., Rebuffa, N., Abdelgalil, R., Siaw Yen Lai, R., Laurence, N., Thomas, S., Green, C., Frostick, R., Khera, R., Povey, M., Wong, H. L., Mccusker, C., Hlukha, L., Pike, G., Kamel, F., Thakkar, R., Donaldson, C., Sequeira Campos, M., Armitage, M. N., Hussain, A. S., Hardy, B., Hassan Serry, M. Y., Bradbury, M., Osunronbi, T., Tam, L. Y. C., Khanan Kaabneh, A., Lawther, J., Fisher, P., Tribedi, T., Moosa, A., Ramdin, A., Goble, M., Downs, E., Wheldon, L., Baggus, E., Mandal, A., Nayeem, A., Ahmed, S., Fradley, W., Wilson, C., Gallagher, S., Criswell, T., Ward, J., Mukkavilli, A., Stubbs, B., Fordyce, W., Suchdev, N., Wei Lim, S., Sookramanien, S. R., Chan, A., Bointas, G., Paul, M., Ward, K. L., Bagnall, M., Pherwani, S. A., Wang, K., Mitchell, L., Heyworth, J., Ayyar, S., Polson, R., Mackenzie, E., Doyle, N., Habib, Z., Zardab, M., Sartaj, F., Farooq, H., Tabibi, M., Drury, D. J., James, S. J., Barnett, R., Teasdale, A. B., Richardson, E. T. J., Thomas, D. A., Williams, R. L., Najabat-Lattif, H. F., Cahya, E., Lou, G., Coyle, M., Homyer, K., Zhu, L. Y., Woods, M., Chang, J., O'Callaghan, H., Suchett-Kaye, I., Mihailidis, T. H., Alawattegama, H., Seite, E., Barrett, A., Riordan, E., Lam, W., Dowdeswell, M., Mulvenna, C., Awokoya, O., Gurowich, L., Dhera, K., Hayat, S., Tincknell, L., Spazzapan, M., Teeling, F., Sysum, K., Latter, J., Latter, M., Khan, S., Guruswamy, M., Beedham, W., Brazier, E., Elghobashy, M., Bajaj, M., Mann, H., Etel, E., Woodmass, M., Hayden, H., Ali, Y., Husain, S., Arnold, A., Pedersen, A. C., Cunha, P., Ahmed, M., Al Zawawi, S., Kudva, V., Theodoropoulou, K., Miscampbell, M., Robinson, A. V., Johnston, J., Dharni, A., Lamb, S., Westerman, T., Evans, E., Campbell, L., Gillespie, M., Cheong, C. M., Kulathevanayagam, K., Varghese, A., Ike, S. I., Chu, T. S. M., Baljer, B., Mogg, J. A. W., Rai, P., Claireaux, H. A., Williams, M., Smillie, R., Goetz, J., Appleby, E., Fadipe, T., Vaughan-Burleigh, S., Puri, G., Hussain, P., Flather, R., Cutler, A., Pathak, S., Sheldon, J., Collicott, T., al-Ausi, M., Jovaisaite, A., Shah, S. M., Khalid, N., Gutmann, D., Davison, S., Alame, Y. J., Syed, L., Owen, W. J., Ahsan, S. D., Anthony-Uzoeto, U., Macleod Hall, C., Zheng, S., Wynter, K., James, C., Sapre, D., Ghosh, R., Baird, J., Cockburn, L., Blackwood, O., Simpson, W., Jeong, S., Bishop, S., Bate, R., Hobson, C., Adam, A. H., Redclift, C., Do, J., Adeleye, O., Poli, F., Batterham, A., Brown, S., Parekh, J. N., Clay, W., Pieri, K., Jackson, A., Saxena, A., Gurung, B., Oyebola, T., O'Brien, F., Djeugam, B., Gardezi, S., Ul-Hasan, S., Martin-Hernandez, M. P., Sisley, M., Modi, S., Antakia, R., Elbayouk, A., Soh, Y. J., Mather, J., Yusuf, Z., Al-Sarraf, Z., Naja, M., Rassool, S. B., Convill, J., Nikookam, Y., Warsame, A., Pace, C., Kiandee, M., Ridwan, R., Carey, C., Hirri, F., Mcmillan, M. J. A., Ling, J. J., Pendelbury, L., Kerimzade, K., Tang, A., Howard, E. O., Humayun, S., Wadsworth, O. J., Tan, K., Abdelhameed, F., Haglund, C., Radnaeva, I., Hu, N., Rambhatla, S., Waldron, D., Madahar, P., Malik, S., Meney, L. C., Ibrahim, I., Kang, C. K., Chiu, J. Z. J., Livie, V., Ibrahim, B., Khalil, M., Pooley, G., Shishkin, B., Docherty, J., Southgate, A., Coomes, A., Mcgee, F., Flanagan, S., Tan, Q. J., Anwar, H., Clough, R., Chrisp, B., Cassels, J., Cross, G. W. V., Mercer, L., Mercer, C., Refalo, A., Hadley, R., Mctighe, A., Farrow, F., Brodie, A., Davis, G., Shah, D. R., Bowers, C., Patel, S., Morice, O., Burzic, A., Cheung, J., Shashidhara, A., Theodoraki, G., Birk, J., Ong, A., Ng, M. P. E., Wong, R. T. W., Maese, S., Yeap, B., Iqbal, Z., Rojoa, D. M., Cabaleiro Barciela, C., Ruddy, C. M., Lindwe, S., Qamar, Y., Chuita, S., Melaugh, T., Hall, J. D., Kouli, O., Hassane, A. S. I., Azhar, A. W., Tan, T. K., Perchard, W., Scurr, T., Campbell, E., Kelk, L., Ghosh, A., Gibbins, A., Mala, D., Loizidou, A., Hall, O., Mecia, L., Hew, C., Varathan, K., Tong, L., Chandrasekar, B., Buchanan, E., O'Connell, M., Kwak, S. Y., Ong, E. H., Gardner, S., Lim, J., Maden, C., Illahi, M., Xuan Tan, Z., Stahl, R., Stahl, J., Hickman, A., Collett, D., Goolam-Mahomed, Z., Allen, B., Atiyah, A., Ahmad, H., Jones, J., Mcgregor, O., Ogundiya, E., Boulbadaoui, A., Kirnon-Jackman, O., Lim, Q. X., Peckham, H., Yeoh, T., Yong, S. Q., Chen, J. Y., Siva, S., Sam, Z. H., Gilani, M., Goh, Y. N., Muthukumar, M. G., Phillips, S., Tjoakarfa, J., Giri, A., Suresan, S., Thomas, P., Johnson, T. A., Williams, R. I., Rashid, A., Kushairi, A., Rais, A., James, A., Bugelli, M., Chechelnitskaya, Y., Sandhu, N., Tandon, R., Gray, M., Kumar, A., Ciurleo, C., Nyamali, I., Hiremath, S., Sinha, S., Chowdhary, M., Bradley, E., Mctiernan, M., Macdonald, S., Sharkey, S., Mclaughlin, N., Amey, C., Kraria, L., Skan, O., Kind, C., Tupper, P., Van Rhee, C., Honeyman, S. I., Menon, G., Jegatheeswaran, L., Madhavan, A., Warne, M., Malcolm, F. L., Lessware, T., Wilkerson, H. T., Chatterjee-Woolman, S., Yoong, A., Ahmed, W. U. 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E., Khosla, S., Samake, M., Shaban, F., Aftab, R., Gough, M., Woodburn, B., Vayalapra, S., Mcmurrugh, K., Jimulia, D., Deol, S., Pike, S., Embury-Young, Y., Patel, M., Kilgallon, E., Keating, R., Walsh, A., Khan, H., Logue, G., Orekoya, M., Alasmar, M., Charalambides, M., Clave Llavall, A., Williamson, E., Bharwada, Y., Zearmal, S., Evans, H., Panikkar, M., de la Cruz, G., Caplan, J., Ruparelia, A., Tanvir, T., Soare, C., Pang, Y. L., Trotter, J., Zaidi, A., Thakrar, V., Pulickal, P., Ahmed, H., Parnell, J., Lennock, S., Ford, V., Brignall, R., O'Neill, D., Hanna, R., Kane, R., Nicola, M., Rajput, K., Xiao, Y., Michael, S., Wright, E., Juniper, S., Thompson, E., Hoskyns, L., Kanitkar, A., Ross, C., Unsworth, A., Rshaidat, H., Demarre, K., Chiang, A., Bareh, A., van Dellen, J., Faqihinejad, C., Gadhvi, A., Grant, R., Lewsey, J., Morris, A., Martin, H., Mcclarty, C., Sanyal, S., Alsaif, A., Palkhi, A., Bhopal, S., Vishnu K, S., Papanikolaou, A., Mitra, A., Nur, A., Ali, F., Burford, C., Huq, T., Irwin, E., Matthews, L., Ngu, W. S., Hosfield, T., Muneeb, F., Page, O., Zeb, E., Al-Azzawi, A., Mcintosh, J., Vucicevic, A., Hughes, M., Brooks, L., Fanibi, B., Dixon, M., Njoku, P., Morris, D., Jobson, J., Chowdhury, H., Alawode, D. O. T., Wynell-Mayow, W., Udayachandran, V., Alsoof, D., Ekert, J., Joseph, N., Zulkefley, N., Hunt, G., Christodoulou, T., Wright, O., Soman, S., Jamal, M., Beqiri, S., Borgas, P., Christie, S., Pereira, F., Browne, S., Yiu, J., Dworkin, A., Brayley, J., Palmer, A., Charalambos, M., Jones, C. S., Toner, S., Cowden, R., Lee, L., Nicol, P., Holman, O., Imtiaz, M., Albert, V., Leung, S. P., Erotocritou, M., Stroud, R., Wilkin, R., Thomson, W., Mackee, L., G, N., Bei, Y., Mckenna Favier, S., Ibrahim, A., Kler, A., Reynolds, L., Mohamed, S. H., Majeed, Y., Fakim, B., Jones, A., Liversedge, G., Carrington, Z., Windebank, J., Izzarina, A., Akbani, U., Craven, J., Aldarragi, A., Harding, S., Millward, A., Bedford, M., Gopalan, V., Midgen, A., Khadka, P., Cheng, O., Taneja, S., Manobharath, N., Kok, J. Y., Lim, D. W. E., Buick, T., Boland, M., Piya, S., Devlin, R., Fairfield, C. J., George, R. J., Rahi, M., Zaman, S., Hajiev, S., Ross, T., Crisp, E., Thompson, C., Charalambous, A., Hollywood, J. L., Hammond, R. F. L., Matthews, J., Mendonca, V., Spinty, J., Khan, K., Cheng, J., Glynn, N., Muhammad, U., Khan, M., Anderson, L., Mccormack, K., Mak, J., Patrawala, S., Milinkovic, N., Schofield, R., Chauhan, M., Hartley, L., Hind, J., Nelson, L., Ratnasingham, D., Whitehead, T., Dimitriadis, S., Marshall, K., Flint, E. J., Horner, C., Heybourne, A., Morgan, H., Wickstone, C., Panagiotou, D., O'Connell, E., Dean, K., Iqbal, R., Walsh, L., Yu, N., Rana, N., Massie, E., Ng, J., Jung, M., Lee, Y. D., Harris, M., White, S., Boev, B., Tonchev, P., Prochazka, V., Skalicky, A., Ravn, S., Ojakaar, A., Dorr-Harim, C., Koutserimpas, C., Giraudo, G., Armellini, A., Ruzzenente, A., Mazzeo, C., De Padua, C., Realis Luc, A., Maroli, A., Giani, I., Cufari, M. E., Vitali, M., Gusai, G. P., Quattromani, R., Virgilio, E., Berti, S., Di Mola Ospedale SS Annunziata, F. F., Papagni, V., Tuminello, F., Vittori, L., Longheu, A., Loche, G. A., Braccio, B., De Luca, E., Resta, G., Ancans, G., Tamosiunas, A., Petrulionis, M., Andrejevic, P., Stellingwerf, M. E., Abdulrahman, N., van de Pas, K. G. H., Thomas, G., Brandsma, A. M., Davids, J., Rottier, S. J., de Roy van Zuidewijn, D., Hawkins, R., Ong, H. I., Li, Y., Desmond, B., Winstanley, J., Martins, M., Americano, M., Frade, S., Senhorinho, R., Peixoto, R., Alves-Vale, C., Lamas, M., O'Connor, D. B., Hoo, M., Gopaul, A., Scanlon, K., O'Dwyer, N., Jovanovic, M., Panyko, A., Van Vuuren, S., Centeno, A., Bernado, I. R., Paniagua Garcia Senorans, M., Gonzalez Amor, L., Cuenca Ramirez, A., Abrisqueta, J., Estaire Gomez, M., Arroyo, A., Cerdan, C., Gomez Romeu, N., Enriquez-Navascues, J. M., Collado-Roura, F., Curchod, P., Gaspar, S., Imadalou, L., Mutlu, D., Akyol, C., Uygur, F. A., Eray, I. C., Biyiklioglu, O., Cetin, M. F., Isik, A. E., Karip, B., Dogan, H., Sarigul, L., Tunc, E., Aydin, T., Bodur, S., Karabulut, K., Francis, A. A., Al-hadithi, A., To, N., Lau, I. S. F., Smith, E., Mahapatra, S., Mcauliffe, O., Imam, L., Akram, B., Hossaini, S., Davies, R., Ko, M., Collins, J., Pandya, A., Reilly, S., Archer, J., Auty, C., Roche, C. D., Livie, J., Chaudhry, F. A., Ntakomyti, E., Diallo, R., Bylinski, T., Wright, J., Masiha, E., Tung, J., Shirazi, B., Neilson, A., Epton, S., Patel, N., Trussell, S., Couldrey, A., Donnelly, C., Eftychiou, S., Persiani R. (ORCID:0000-0002-1537-5097), Glasbey, J. C., Bibi, S., Pata, F., Ozkan, B. B., Van Straten, S., Hodson, J., Chapman, S. J., Blanco-Colino, R., Pellino, G., Sgro, A., Soares, A., van Elst, T., Nepogodiev, D., Borakati, A., Bath, M. F., Yasin, I. H., Mclean, K., Arthur, T., Kovacevic, M., Delibegovic, S., Karamanliev, M., Swamad, M., Zebrak, R., Paramasivam, R., Martensen, A., Larsen, H. M., Radeker, L., Frey, P. E., Kechagias, A., Venara, A., Duchalais, E., Ioannidis, A., Pasquali, S., Simioni, A., Farina, V., Podda, M., Lorenzon, L., Itsurg, I., Schaeff, V., Otto, A., Jakubauskas, M., van Elst, T. 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R., Longshaw, A., Flannery, O., Green, R., Leaning, M., Cragg, J., Sharriff, H., Doherty, C., Kwan, K. W. L., Sanders-Crook, L., Bhatia, S., Eames, S., Lewis, F., Kirupananthan, P., Boh, Z. Y., Dass, S., Soma, A., Newton, A., Hill, M., Shafiq, Y., Brkljac, M., Boyce, L., English, W. J., Lam, S., Chipeta, C., Jain, C., Garofalidou, T., Novotny, S. A., Locke, S., Bowman, C., Begaj, A., Murphy, C., Radcliffe, K., Chong, J. T., Jeffrey, E., Chaudhury, N., Rajendran, K., Akbar, Z., Walters, B., Kulendrarajah, B., Tran, N., Shrestha, S., Parmar, S., Gallagher, C., Hennessy, L., Pentti, E., Badhrinarayanan, S., Fung, A., Mansoor, M., Kenny, R., Kan, P., Lee, D. E., Khosla, S., Samake, M., Shaban, F., Aftab, R., Gough, M., Woodburn, B., Vayalapra, S., Mcmurrugh, K., Jimulia, D., Deol, S., Pike, S., Embury-Young, Y., Patel, M., Kilgallon, E., Keating, R., Walsh, A., Khan, H., Logue, G., Orekoya, M., Alasmar, M., Charalambides, M., Clave Llavall, A., Williamson, E., Bharwada, Y., Zearmal, S., Evans, H., Panikkar, M., de la Cruz, G., Caplan, J., Ruparelia, A., Tanvir, T., Soare, C., Pang, Y. L., Trotter, J., Zaidi, A., Thakrar, V., Pulickal, P., Ahmed, H., Parnell, J., Lennock, S., Ford, V., Brignall, R., O'Neill, D., Hanna, R., Kane, R., Nicola, M., Rajput, K., Xiao, Y., Michael, S., Wright, E., Juniper, S., Thompson, E., Hoskyns, L., Kanitkar, A., Ross, C., Unsworth, A., Rshaidat, H., Demarre, K., Chiang, A., Bareh, A., van Dellen, J., Faqihinejad, C., Gadhvi, A., Grant, R., Lewsey, J., Morris, A., Martin, H., Mcclarty, C., Sanyal, S., Alsaif, A., Palkhi, A., Bhopal, S., Vishnu K, S., Papanikolaou, A., Mitra, A., Nur, A., Ali, F., Burford, C., Huq, T., Irwin, E., Matthews, L., Ngu, W. S., Hosfield, T., Muneeb, F., Page, O., Zeb, E., Al-Azzawi, A., Mcintosh, J., Vucicevic, A., Hughes, M., Brooks, L., Fanibi, B., Dixon, M., Njoku, P., Morris, D., Jobson, J., Chowdhury, H., Alawode, D. O. T., Wynell-Mayow, W., Udayachandran, V., Alsoof, D., Ekert, J., Joseph, N., Zulkefley, N., Hunt, G., Christodoulou, T., Wright, O., Soman, S., Jamal, M., Beqiri, S., Borgas, P., Christie, S., Pereira, F., Browne, S., Yiu, J., Dworkin, A., Brayley, J., Palmer, A., Charalambos, M., Jones, C. S., Toner, S., Cowden, R., Lee, L., Nicol, P., Holman, O., Imtiaz, M., Albert, V., Leung, S. P., Erotocritou, M., Stroud, R., Wilkin, R., Thomson, W., Mackee, L., G, N., Bei, Y., Mckenna Favier, S., Ibrahim, A., Kler, A., Reynolds, L., Mohamed, S. H., Majeed, Y., Fakim, B., Jones, A., Liversedge, G., Carrington, Z., Windebank, J., Izzarina, A., Akbani, U., Craven, J., Aldarragi, A., Harding, S., Millward, A., Bedford, M., Gopalan, V., Midgen, A., Khadka, P., Cheng, O., Taneja, S., Manobharath, N., Kok, J. Y., Lim, D. W. E., Buick, T., Boland, M., Piya, S., Devlin, R., Fairfield, C. J., George, R. J., Rahi, M., Zaman, S., Hajiev, S., Ross, T., Crisp, E., Thompson, C., Charalambous, A., Hollywood, J. L., Hammond, R. F. L., Matthews, J., Mendonca, V., Spinty, J., Khan, K., Cheng, J., Glynn, N., Muhammad, U., Khan, M., Anderson, L., Mccormack, K., Mak, J., Patrawala, S., Milinkovic, N., Schofield, R., Chauhan, M., Hartley, L., Hind, J., Nelson, L., Ratnasingham, D., Whitehead, T., Dimitriadis, S., Marshall, K., Flint, E. J., Horner, C., Heybourne, A., Morgan, H., Wickstone, C., Panagiotou, D., O'Connell, E., Dean, K., Iqbal, R., Walsh, L., Yu, N., Rana, N., Massie, E., Ng, J., Jung, M., Lee, Y. D., Harris, M., White, S., Boev, B., Tonchev, P., Prochazka, V., Skalicky, A., Ravn, S., Ojakaar, A., Dorr-Harim, C., Koutserimpas, C., Giraudo, G., Armellini, A., Ruzzenente, A., Mazzeo, C., De Padua, C., Realis Luc, A., Maroli, A., Giani, I., Cufari, M. E., Vitali, M., Gusai, G. P., Quattromani, R., Virgilio, E., Berti, S., Di Mola Ospedale SS Annunziata, F. F., Papagni, V., Tuminello, F., Vittori, L., Longheu, A., Loche, G. A., Braccio, B., De Luca, E., Resta, G., Ancans, G., Tamosiunas, A., Petrulionis, M., Andrejevic, P., Stellingwerf, M. E., Abdulrahman, N., van de Pas, K. G. H., Thomas, G., Brandsma, A. M., Davids, J., Rottier, S. J., de Roy van Zuidewijn, D., Hawkins, R., Ong, H. I., Li, Y., Desmond, B., Winstanley, J., Martins, M., Americano, M., Frade, S., Senhorinho, R., Peixoto, R., Alves-Vale, C., Lamas, M., O'Connor, D. B., Hoo, M., Gopaul, A., Scanlon, K., O'Dwyer, N., Jovanovic, M., Panyko, A., Van Vuuren, S., Centeno, A., Bernado, I. R., Paniagua Garcia Senorans, M., Gonzalez Amor, L., Cuenca Ramirez, A., Abrisqueta, J., Estaire Gomez, M., Arroyo, A., Cerdan, C., Gomez Romeu, N., Enriquez-Navascues, J. M., Collado-Roura, F., Curchod, P., Gaspar, S., Imadalou, L., Mutlu, D., Akyol, C., Uygur, F. A., Eray, I. C., Biyiklioglu, O., Cetin, M. F., Isik, A. E., Karip, B., Dogan, H., Sarigul, L., Tunc, E., Aydin, T., Bodur, S., Karabulut, K., Francis, A. A., Al-hadithi, A., To, N., Lau, I. S. F., Smith, E., Mahapatra, S., Mcauliffe, O., Imam, L., Akram, B., Hossaini, S., Davies, R., Ko, M., Collins, J., Pandya, A., Reilly, S., Archer, J., Auty, C., Roche, C. D., Livie, J., Chaudhry, F. A., Ntakomyti, E., Diallo, R., Bylinski, T., Wright, J., Masiha, E., Tung, J., Shirazi, B., Neilson, A., Epton, S., Patel, N., Trussell, S., Couldrey, A., Donnelly, C., Eftychiou, S., and Persiani R. (ORCID:0000-0002-1537-5097) more...
- Abstract
Aim: Aspiration is a common cause of pneumonia in patients with postoperative ileus. Insertion of a nasogastric tube (NGT) is often performed, but this can be distressing. The aim of this study was to determine whether the timing of NGT insertion after surgery (before versus after vomiting) was associated with reduced rates of pneumonia in patients undergoing elective colorectal surgery. Method: This was a preplanned secondary analysis of a multicentre, prospective cohort study. Patients undergoing elective colorectal surgery between January 2018 and April 2018 were eligible. Those receiving a NGT were divided into three groups, based on the timing of the insertion: routine NGT (inserted at the time of surgery), prophylactic NGT (inserted after surgery but before vomiting) and reactive NGT (inserted after surgery and after vomiting). The primary outcome was the development of pneumonia within 30 days of surgery, which was compared between the prophylactic and reactive NGT groups using multivariable regression analysis. Results: A total of 4715 patients were included in the analysis and 1536 (32.6%) received a NGT. These were classified as routine in 926 (60.3%), reactive in 461 (30.0%) and prophylactic in 149 (9.7%). Two hundred patients (4.2%) developed pneumonia (no NGT 2.7%; routine NGT 5.2%; reactive NGT 10.6%; prophylactic NGT 11.4%). After adjustment for confounding factors, no significant difference in pneumonia rates was detected between the prophylactic and reactive NGT groups (odds ratio 1.03, 95% CI 0.56–1.87, P = 0.932). Conclusion: In patients who required the insertion of a NGT after surgery, prophylactic insertion was not associated with fewer cases of pneumonia within 30 days of surgery compared with reactive insertion. more...
- Published
- 2020
26. Chemically-defined induction of a primitive endoderm and epiblast-like niche supports post-implantation progression from blastoids
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Misteli Guerreiro I, Bon-Kyoung Koo, Jop Kind, Scholte op Reimer Ys, Frias Aldeguer J, van Blitterswijk Ca, Nicolas C. Rivron, and E.J. Vrij
- Subjects
Homeobox protein NANOG ,0303 health sciences ,Morphogenesis ,Embryoid body ,Biology ,Cell biology ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Epiblast ,embryonic structures ,medicine ,Conceptus ,Blastocyst ,Stem cell ,030217 neurology & neurosurgery ,reproductive and urinary physiology ,030304 developmental biology ,G protein-coupled receptor - Abstract
The early mammalian conceptus (blastocyst) contains two supporting extraembryonic tissues - the trophectoderm and the primitive endoderm (PrE) - that encase and guide the epiblast (Epi) to eventually form the all body. Modifications of the conceptus exposed key genes regulating these tissues co-development. However, the combinations of signalling pathways underlying the interplay of PrE and Epi remains elusive. Stem cell-based models including embryoid bodies and blastoids can be generated in large numbers and subjected to high-content screens. Here, we use combinatorial screens of proteins, GPCR ligands and small molecules to rapidly (72 hours) and efficiently (80%) guide embryoid bodies to form a three-dimensional PrE-/Epiblast-like niche in chemically-defined conditions (gel-free, serum-free). This bipotent niche spontaneously progresses, without growth factors, to form a pro-amniotic cavity surrounded by a polarized Epi covered with parietal and visceral endoderm-like cells. In blastoids, these molecules enhance the ratio and number of Gata6+/Nanog+ cells and promote the survival, expansion and morphogenesis of a post-implantation-like Epiin vitro. Altogether, modelling early development in chemically-defined conditions delineates the pathways sufficient to form a functional PrE/Epiblast niche that fuels post-implantation development. more...
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- 2019
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27. Life cycle assessment of experimental diets with different protein/carbohydrate ratios and fishmeal or plant-feedstuffs-based to gilthead seabream (Sparus aurata)
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Belmira Neto, Basto Silva, C., Guerreiro, I., Oliva-Teles, A, Faculdade de Engenharia, and Faculdade de Ciências
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- 2018
28. P2.09-22 Molecular and Immunological Profiles of Lung Carcinoma: Are They Associated?
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Cruz, A., primary, Guerreiro, I., additional, Silva, M.J., additional, Leitão, M.J., additional, Rodrigues, A., additional, Azevedo, I., additional, Pousa, I., additional, Oliveira, J., additional, Oliveira, C., additional, Rosinha, A., additional, Cassiano, M., additional, Cunha, A.L., additional, and Soares, M., additional more...
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- 2019
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29. CYNARA PASTA – Uma abordagem integrada para a valorização da folha de Cynara cardunculus
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Carvalho, M.J.B., Reis, J., Paulino, A., Costa, M. B., Dias, J., Alvarenga, N.B., Guerreiro, I., Regato, M., Brás, T., and Duarte, M. F.
- Abstract
O cardo é uma planta que cresce naturalmente, em condições extremas, como seja o caso de altas temperaturas e stress hídrico no verão, e em solos não cultivados. O cardo é um recurso endógeno abundante, com elevado potencial de valorização económica baseado na sua aptidão tecnológica. Tradicionalmente, a flor do cardo é usada no processamento de queijos de ovelha, nomeadamente “Serra da Estrela”, “Serpa”, “Évora”, “Nisa”, entre outros, em Portugal, “La Serena” e “Guía” em Espanha. Atualmente, revela várias evidências epidemiológicas que sugerem que o consumo de vegetais pode prevenir doenças degenerativas causadas por stress oxidativo. Consequentemente há uma nova tendência por parte do consumidor na procura de novos produtos, derivados de matrizes naturais, que representem uma importante fonte de antioxidantes exógenos, como sejam os compostos fenólicos. No sentido de promover a valorização económica da planta Cynara cardunculus, tendo por base o potencial fitoquímico das folhas, a variabilidade natural de populações espontâneas de cardo, e a utilização da flor para a produção de queijos, surgiu o projeto ValBioTecCynara que contempla uma abordagem integrada para a valorização da flor e da folha, potenciando a cultura do cardo, associando-lhe soluções tecnológicas de elevado valor acrescentado. No presente estudo desenvolveu-se uma pasta à base de folhas de Cynara cardunculus colhidas entre os meses de fevereiro e março, que foram previamente branqueadas (100ºC/5 min), embaladas em vácuo e congeladas a -24ºC. Posteriormente foram efetuados diferentes ensaios de modo a otimizar a textura da pasta de cardo, cuja formulação incluiu azeite, cebola, incorporação de leguminosas (Phaseolus vulgaris L. e Cicer arietinum), ervas aromáticas (Petroselinum crispum e Coriandrum sativum) e, por último para adição de açúcar amarelo e/ou mel. Em termos de caracterização analítica, a pasta apresentou um pH na ordem da neutralidade (6,2 a 6,6), a avaliação da cor Lab da CIE, apresentou valores de L entre 45,03 e 39,76, e os parâmetros a e b entre -5,73 e 0,36, e 16,09 e 10,83, respetivamente, em termos de avaliação reológica, as amostras foram sujeitas a um ensaio de TPA (“Texture Profile Analysis”) e apresentaram valores de dureza entre 0,44N a 0,96 N e adesividade entre 2,20 e 3,54 Ns. Nas pastas de cardo, o teor de água apresentou-se entre 54,07% e 68,55%, e os hidratos de carbono na pasta com 68,55% de água foram 12,93% e 22,08% na pasta com 54,07% de água, em relação à fibra, os teores foram entre 3,34% e 0,99%. Quer a proteína, quer a cinza mantiveram uma constância de valores em todas as pastas, sem quaisquer diferenças significativas entre amostras e com um valor médio de 1,29%. O teor de gordura apresentou diferenças significativas entre as diferentes formulações. Ao efetuar-se uma análise sensorial afectiva, as pastas destacaram um sabor intenso a amargo, particularmente acentuado nas pastas elaboradas com as folhas colhidas em março, o que poderá suscitar numa perspectiva futura, e tendo como foco a elaboração de uma pasta de barrar, que se deva optar pela antecipação da colheita das folhas. info:eu-repo/semantics/publishedVersion more...
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- 2017
30. Estados fenológicos do marmeleiro
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Regato, M. A., Guerreiro, I. M., and Regato, J. E.
- Abstract
No Centro Hortofrutícola da Escola Superior Agrária do Instituto Politécnico de Beja, está instalado um pequeno pomar demonstrativo de marmeleiro, que foi plantado em 1996, com uma área de 0,067 hectares, com as cultivares Gigante de Vranja e Portugal, num compasso de 6 m x 4 m, conduzidas em vaso. O presente estudo consistiu na observação dos estados fenológicos e na caracterização do fruto, relativamente aos parâmetros, peso médio, diâmetro transversal e longitudinal, dureza e conteúdo em sólidos solúveis totais e na determinação da produtividade das referidas cultivares. Relativamente aos estados fenológicos, verificou-se que a cultivar Gigante de Vranja é mais temporã do que a cultivar Portugal, iniciando o abrolhamento no início de fevereiro, enquanto esta última, o inicia em meados de fevereiro. O vingamento e o desenvolvimento do fruto também ocorrem mais cedo na cultivar Gigante de Vranja, assim como, a maturação e colheita, que se verificam a partir da segunda quinzena de setembro nesta cultivar, e apenas a partir do início de outubro na cultivar Portugal. A produtividade média da cultivar Gigante de Vranja foi de 18,5 t ha-1 e a da cultivar Portugal foi de 12,0 t ha-1. O fruto da cv. Gigante de Vranja apresentou o peso de 344 g, grande calibre (87 mm) e forma oblonga (diâmetro longitudinal de 104 mm). A epiderme é de cor amarelo limão, algo brilhante. A polpa é amarelada, consistente (dureza de 8,69 kg/0,5 cm2), doce (16,9 % de sólidos solúveis totais) e de sabor agradável. É muito perfumado quando bem maduro. A cultivar Portugal apresentou um fruto com um bom calibre (85 mm) e forma arredondada (diâmetro longitudinal de 81 mm). A epiderme é de cor amarelo limão com alguma pubescência esbranquiçada. A polpa é amarelada, consistente (dureza de 8,61 kg/0,5 cm2), menos doce (16,1 % de sólidos solúveis totais), ácida e algo adstringente. É perfumado quando bem maduro. info:eu-repo/semantics/publishedVersion more...
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- 2017
31. Comportamento da Anarsia lineatella em pomares de amendoeiras no Alentejo
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Patanita, M. I., Guerreiro, I., and Regato, M.
- Abstract
Sendo o amendoal moderno uma cultura alternativa na região do Alentejo e perspetivando-se para os próximos anos um enorme incremento em termos de área plantada e investimento efetuado torna-se premente o estudo da adaptabilidade das variedades nesta região bem como o comportamento dos principais inimigos da cultura. Sendo uma das principais pragas a espécie Anarsia lineatella (Lepidoptera, Gelechiidae) pretende-se neste trabalho melhorar o conhecimento do seu comportamento na região e em diferentes variedades. O estudo decorreu no período compreendido entre fevereiro e julho de 2016 e em cinco variedades, sendo elas Ferragnês, Ferraduel, Francoli, Glorieta e Masbovera. Para avaliar a curva de voo desta praga utilizaram-se 5 armadilhas sexuais do tipo Delta. Os resultados obtidos não nos permitem diferenciar suscetibilidades varietais. info:eu-repo/semantics/publishedVersion more...
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- 2017
32. Atividade de Investigação e Desenvolvimento Experimental nos Laboratórios de Tecnologias de Regadio e de Ensino de Ciências da Terra e da Atmosfera do IPBeja
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Ramôa, S., Silva, P. Oliveira e, Guerreiro, I., Portugal, J., and Vasques, A. Lopes
- Abstract
Perspetivando a possibilidade de futuras colaborações nas áreas da Rega, dos Solos e aplicações da Agrometeorologia, apresenta-se uma breve síntese dos trabalhos de investigação e desenvolvimento experimental realizados nos últimos 4 anos no âmbito dos Laboratórios de Tecnologias de Regadio e de Ensino de Ciências da Terra e da Atmosfera do Departamento de Biociências do Instituto Politécnico de Beja. O primeiro é uma infraestrutura de apoio ao Ensino e à Investigação, que integra um conjunto de equipamentos de laboratório e de campo cuja utilização tem sido orientada para atividades nas áreas da Rega e da Conservação do Solo e da Água. O segundo desenvolve atividades essencialmente didáticas, de formação e ensino na área das Ciências da Terra e da Atmosfera, cujo objetivo principal é garantir uma formação propedêutica nessas áreas científicas de modo a que, os formandos, sejam capazes de aplicar os conceitos adquiridos nas disciplinas da especialidade necessários à sua atividade profissional no domínio das Ciências Agrárias. É, também, utilizado como apoio à atividade de investigação que decorre no laboratório de Tecnologias de Regadio. A equipa de colaboradores destes laboratórios tem integrado, desde o início dos anos 90, equipas multidisciplinares e interinstitucionais, que têm desenvolvido projetos de investigação e de demonstração nestas áreas. No conjunto dos trabalhos realizados, dá-se destaque a dois novos projetos que estão a iniciar durante o ano 2017: o projeto ‘WineWaterFootprint - Avaliação da pegada hídrica na fileira vitivinícola’, coordenado pelo Instituto Politécnico de Santarém e que tem como objetivo avaliar a pegada hídrica ao longo da cadeia de valor vitivinícola, através do desenvolvimento de uma metodologia aplicada a estudos de caso e de uma ferramenta de apoio à gestão; o projeto ‘INNOACE- Propostas para uma gestão eficiente de fruteiras mediante estratégias de rega e fertilização no Alentejo e Extremadura’, coordenado pelo Centro de Investigaciones Científicas y Tecnológicas de Extremadura (CICYTEX) e que tem como objetivo avaliar o efeito de diferentes estratégias de rega e doses de fertilização, recorrendo a técnicas culturais que irão permitir otimizar a produção, a qualidade da colheita e pós colheita, com o menor impacto possível, bem como fazer a transferência de conhecimento para o setor agrícola. info:eu-repo/semantics/publishedVersion more...
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- 2017
33. Eficiência no uso do azoto, fósforo e potássio em sistemas culturais regados no Baixo Alentejo
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Guerreiro, I., Patanita, M., Tomaz, A., Palma, J. Ferro, Dôres, J., and Boteta, L.
- Abstract
Com base num projeto de demonstração que decorreu nos anos agrícolas 2012/2013 e 2013/2014, realizado em duas explorações agrícolas localizadas no perímetro de rega de Alqueva, quantificou-se a eficiência de uso do azoto, fósforo e potássio (NUE) numa monocultura de milho (M-M) e em duas rotações, cevada+milho-cevada (C+M-C) e girassol-cevada+milho (G-C+M). A avaliação dos teores de matéria orgânica total, fósforo e potássio extraíveis fez-se no ano anterior à instalação do ensaio e previamente à sementeira de cada cultura. Na determinação da eficiência de uso dos nutrientes usaramse as relações seguintes: (I) eficiência de uso do azoto (N) disponível (kg/kg), dada por NUEN=R/ND; (II) eficiência de uso do fósforo (P) disponível (kg/kg), dada por NUEP=R/PD; (III) eficiência de uso do potássio (K) disponível (kg/kg), dada por NUEK=R/KD, onde R é o rendimento da cultura (kg/ha) e ND, PD e KD correspondem, respetivamente, ao N disponível (kg/ha de N) resultante da fertilização mineral e do N libertado por mineralização da matéria orgânica quando o seu teor no solo ultrapassou 2.5%, ao P disponível (kg/ha de P2O5), resultante da fertilização mineral e do teor extraível existente no solo e ao K disponível (Kg/ha de K2O), resultante da fertilização mineral e do teor extraível existente no solo. No milho os valores NUEN foram superiores em monocultura, com o valor mais baixo a verificar-se na rotação GC+ M, refletindo primordialmente as baixas produtividades obtidas pelo milho cultivado em rotação. Em monocultura a NUEN do milho alcançou valores elevados, superiores a 40 kg/kg. O baixo valor de NUEN no girassol (15 kg/kg) indica que a cultura foi pouco eficiente na utilização do azoto disponível, sobretudo em consequência da baixa produtividade da cultura e não de alguma limitação na capacidade de utilização do N pelo girassol. A NUEP ficou em geral dentro dos intervalos médios espectáveis (45 a110 kg/kg). Foram exceção pela negativa o girassol e o milho na rotação G-C+M. O valor mais elevado de NUEP foi obtido no milho em monocultura e resultou da maior produtividade obtida e da menor disponibilidade de fósforo extraível no solo. Estes resultados demonstram que sempre que o potencial produtivo das culturas foi alcançado, não sendo afetado por fatores de stresse hídrico, fitossanitário ou práticas agronómicas desajustadas, as rotações e as culturas a elas associadas mostraram-se eficientes na utilização deste nutriente. Em todas as culturas a NUEK foi baixa, em geral inferior a 25 kg/kg. Este resultado sugere que as fertilizações potássicas poderiam ter sido inferiores, sem risco de comprometer os rendimentos esperados nem de afetar a fertilidade do solo. O milho foi a cultura mais eficiente na utilização do K. O balanço final dos teores de P e de K extraíveis foi positivo na rotação C+M-C, evidenciando que os nutrientes aplicados via fertilizantes superaram as exportações das culturas. As sucessões M-M e C+M-C apresentaram os melhores indicadores de eficiência de uso de nutrientes, principalmente de azoto e de fósforo. Contudo, verificaram-se, em todas as culturas, baixas eficiências no uso de potássio, evidenciando a necessidade de equacionar cuidadosamente a fertilização potássica. info:eu-repo/semantics/publishedVersion more...
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- 2017
34. Prognostic factors in metastatic colorectal cancer
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Silva, M., primary, Guerreiro, I., additional, Abreu, S., additional, and Marques, D., additional
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- 2018
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35. Comparison of the clinicopathological characteristics and the survival outcomes between the Siewert type II/III adenocarcinomas
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Castela, J., Leitão, C., Sousa, P., Guerreiro, I., Ferro, S. Mão de, Serrano, M., Ferreira, S., Freire, J., Luis, A., Casaca, R., Bettencourt, A., Chaves, P., and Pereira, A. Dias
- Published
- 2016
36. 36th International Symposium on Intensive Care and Emergency Medicine
- Author
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Bateman, R. M., Sharpe, M. D., Jagger, J. E., Ellis, C. G., Solé-Violán, J., López-Rodríguez, M., Herrera-Ramos, E., Ruíz-Hernández, J., Borderías, L., Horcajada, J., González-Quevedo, N., Rajas, O., Briones, M., Rodríguez de Castro, F., Rodríguez Gallego, C., Esen, F., Orhun, G., Ergin Ozcan, P., Senturk, E., Ugur Yilmaz, C., Orhan, N., Arican, N., Kaya, M., Kucukerden, M., Giris, M., Akcan, U., Bilgic Gazioglu, S., Tuzun, E., Riff, R., Naamani, O., Douvdevani, A., Takegawa, R., Yoshida, H., Hirose, T., Yamamoto, N., Hagiya, H., Ojima, M., Akeda, Y., Tasaki, O., Tomono, K., Shimazu, T., Ono, S., Kubo, T., Suda, S., Ueno, T., Ikeda, T., Ogura, H., Takahashi, H., Kang, J., Nakamura, Y., Kojima, T., Izutani, Y., Taniguchi, T., O, M., Dinter, C., Lotz, J., Eilers, B., Wissmann, C., Lott, R., Meili, M. M., Schuetz, P. S., Hawa, H., Sharshir, M., Aburageila, M., Salahuddin, N., Chantziara, V., Georgiou, S., Tsimogianni, A., Alexandropoulos, P., Vassi, A., Lagiou, F., Valta, M., Micha, G., Chinou, E., Michaloudis, G., Kodaira, A., Imaizumi, H., De la Torre-Prados, M. V., Garcia-De la Torre, A., Enguix-Armada, A., Puerto-Morlan, A., Perez-Valero, V., Garcia-Alcantara, A., Bolton, N., Dudziak, J., Bonney, S., Tridente, A., Nee, P., Nicolaes, G., Wiewel, M., Schultz, M., Wildhagen, K., Horn, J., Schrijver, R., Van der Poll, T., Reutelingsperger, C., Pillai, S., Davies, G., Mills, G., Aubrey, R., Morris, K., Williams, P., Evans, P., Gayat, E. G., Struck, J., Cariou, A., Deye, N., Guidet, B., Jabert, S., Launay, J., Legrand, M., Léone, M., Resche-Rigon, M., Vicaut, E., Vieillard-Baron, A., Mebazaa, A., Arnold, R., Capan, M., Linder, A., Akesson, P., Popescu, M., Tomescu, D., Sprung, C. L., Calderon Morales, R., Munteanu, G., Orenbuch-Harroch, E., Levin, P., Kasdan, H., Reiter, A., Volker, T., Himmel, Y., Cohen, Y., Meissonnier, J., Girard, L., Rebeaud, F., Herrmann, I., Delwarde, B., Peronnet, E., Cerrato, E., Venet, F., Lepape, A., Rimmelé, T., Monneret, G., Textoris, J., Beloborodova, N., Moroz, V., Osipov, A., Bedova, A., Sarshor, Y., Pautova, A., Sergeev, A., Chernevskaya, E., Odermatt, J., Bolliger, R., Hersberger, L., Ottiger, M., Christ-Crain, M., Mueller, B., Schuetz, P., Sharma, N. K., Tashima, A. K., Brunialti, M. K., Machado, F. R., Assuncao, M., Rigato, O., Salomao, R., Cajander, S. C., Rasmussen, G., Tina, E., Söderquist, B., Källman, J., Strålin, K., Lange, A. L., Sundén-Cullberg, J. S., Magnuson, A. M., Hultgren, O. H., Van der Geest, P., Mohseni, M., Linssen, J., De Jonge, R., Duran, S., Groeneveld, J., Miller, R., Lopansri, B. K., McHugh, L. C., Seldon, A., Burke, J. P., Johnston, J., Reece-Anthony, R., Bond, A., Molokhia, A., Mcgrath, C., Nsutebu, E., Bank Pedersen, P., Pilsgaard Henriksen, D., Mikkelsen, S., Touborg Lassen, A., Tincu, R., Cobilinschi, C., Ghiorghiu, Z., Macovei, R., Wiewel, M. A., Harmon, M. B., Van Vught, L. A., Scicluna, B. P., Hoogendijk, A. J., Zwinderman, A. H., Cremer, O. L., Bonten, M. J., Schultz, M. J., Juffermans, N. P., Wiersinga, W. J., Eren, G., Tekdos, Y., Dogan, M., Acicbe, O., Kaya, E., Hergunsel, O., Alsolamy, S., Ghamdi, G., Alswaidan, L., Alharbi, S., Alenezi, F., Arabi, Y., Heaton, J., Boyce, A., Nolan, L., Dukoff-Gordon, A., Dean, A., Mann Ben Yehudah, T., Fleischmann, C., Thomas-Rueddel, D., Haas, C., Dennler, U., Reinhart, K., Suntornlohanakul, O., Khwannimit, B., Breckenridge, F., Puxty, A., Szturz, P., Folwarzcny, P., Svancara, J., Kula, R., Sevcik, P., Caneva, L., Casazza, A., Bellazzi, E., Marra, S., Pagani, L., Vetere, M., Vanzino, R., Ciprandi, D., Preda, R., Boschi, R., Carnevale, L., Lopez, V., Aguilar Arzapalo, M., Barradas, L., Escalante, A., Gongora, J., Cetina, M., Adamik, B, Jakubczyk, D, Kübler, A, Radford, A., Lee, T., Singer, J., Boyd, J., Fineberg, D., Williams, M., Russell, J., Scarlatescu, E., Droc, G., Arama, S., Müller, M., Straat, M., Zeerleder, S. S., Fuchs, C. F., Scheer, C. S., Wauschkuhn, S. W., Vollmer, M. V., Meissner, K. M., Kuhn, S. K., Hahnenkamp, K. H., Rehberg, S. R., Gründling, M. G., Hamaguchi, S., Gómez-Sánchez, E., Heredia-Rodríguez, M., Álvarez-Fuente, E., Lorenzo-López, M., Gómez-Pesquera, E., Aragón-Camino, M., Liu-Zhu, P., Sánchez-López, A., Hernández-Lozano, A., Peláez-Jareño, M. T., Tamayo, E., Thomas-Rüddel, D. O., Adora, V., Kar, A., Chakraborty, A., Roy, S., Bandyopadhyay, A., Das, M., BenYehudah, G., Salim, M., Kumar, N., Arabi, L., Burger, T., Lephart, P., Toth-martin, E., Valencia, C., Hammami, N., Blot, S., Vincent, J. L., Lambert, M. L., Brunke, J., Riemann, T., Roschke, I., Nimitvilai, S., Jintanapramote, K., Jarupongprapa, S., Adukauskiene, D., Valanciene, D., Bose, G., Lostarakos, V., Carr, B., Khedher, S., Maaoui, A., Ezzamouri, A., Salem, M., Chen, J., Cranendonk, D. R., Day, M., Penrice, G., Roy, K., Robertson, P., Godbole, G., Jones, B., Booth, M., Donaldson, L., Kawano, Y., Ishikura, H., Al-Dorzi, H., Almutairi, M., Alhamadi, B., Crizaldo Toledo, A., Khan, R., Al Raiy, B., Talaie, H., Van Oers, J. A., Harts, A., Nieuwkoop, E., Vos, P., Boussarsar, Y., Boutouta, F., Kamoun, S., Mezghani, I., Koubaji, S., Ben Souissi, A., Riahi, A., Mebazaa, M. S., Giamarellos-Bourboulis, E., Tziolos, N., Routsi, C., Katsenos, C., Tsangaris, I., Pneumatikos, I., Vlachogiannis, G., Theodorou, V., Prekates, A., Antypa, E., Koulouras, V., Kapravelos, N., Gogos, C., Antoniadou, E., Mandragos, K., Armaganidis, A., Robles Caballero, A. R., Civantos, B., Figueira, J. C., López, J., Silva-Pinto, A., Ceia, F., Sarmento, A., Santos, L., Almekhlafi, G., Sakr, Y., Baharoon, S., Aldawood, A., Matroud, A., Alchin, J., Al Johani, S., Balkhy, H., Yousif, S. Y., Alotabi, B. O., Alsaawi, A. S., Ang, J., Curran, M. D., Enoch, D., Navapurkar, V., Morris, A., Sharvill, R., Astin, J., Patel, J., Kruger, C., O’Neal, J., Rhodes, H., Jancik, J., François, B., Laterre, P. F., Eggimann, P., Torres, A., Sánchez, M., Dequin, P. F., Bassi, G. L., Chastre, J., Jafri, H. S., Ben Romdhane, M., Douira, Z., Bousselmi, M., Vakalos, A., Avramidis, V., Craven, T. H., Wojcik, G., Kefala, K., McCoubrey, J., Reilly, J., Paterson, R., Inverarity, D., Laurenson, I., Walsh, T. S., Mongodi, S., Bouhemad, B., Orlando, A., Stella, A., Via, G., Iotti, G., Braschi, A., Mojoli, F., Haliloglu, M., Bilgili, B., Kasapoglu, U., Sayan, I., Süzer Aslan, M., Yalcın, A., Cinel, I., Ellis, H. E., Bauchmuller, K., Miller, D., Temple, A., Luyt, C. E., Singer, M., Nassar, Y., Ayad, M. S., Trifi, A., Abdellatif, S., Daly, F., Nasri, R., Ben Lakhal, S., Gul, F., Kuzovlev, A., Shabanov, A., Polovnikov, S., Kadrichu, N., Dang, T., Corkery, K., Challoner, P., Bassi, G. Li, Aguilera, E., Chiurazzi, C., Travierso, C., Motos, A., Fernandez, L., Amaro, R., Senussi, T., Idone, F., Bobi, J., Rigol, M., Hodiamont, C. J., Janssen, J. M., Bouman, C. S., Mathôt, R. A., De Jong, M. D., Van Hest, R. M., Payne, L., Fraser, G. L., Tudor, B., Lahner, M., Roth, G., Krenn, C., Jault, P., Gabard, J., Leclerc, T., Jennes, S., Que, Y., Rousseau, A., Ravat, F., Eissa, A., Al-Harbi, S., Aldabbagh, T., Abdellatif., S., Paramba, F., Purayil, N., Naushad, V., Mohammad, O., Negi, V., Chandra, P., Kleinsasser, A., Witrz, M. R., Buchner-Doeven, J. F., Tuip-de Boer, A. M., Goslings, J. C., Van Hezel, M., Boing, A, Van Bruggen, R, Juffermans, N, Markopoulou, D., Venetsanou, K., Kaldis, V., Koutete, D., Chroni, D., Alamanos, I., Koch, L., Walter, E., Maekawa, K., Hayakawa, M., Kushimoto, S., Shiraishi, A., Kato, H., Sasaki, J., Matauoka, T., Uejima, T., Morimura, N., Hagiwara, A., Takeda, M., Tarabrin, O., Shcherbakow, S., Gavrychenko, D., Mazurenko, G., Ivanova, V., Chystikov, O., Plourde, C., Lessard, J., Chauny, J., Daoust, R., Kropman, L., In het Panhuis, L., Konings, J., Huskens, D., Schurgers, E., Roest, M., De Laat, B., Lance, M., Durila, M., Lukas, P., Astraverkhava, M., Jonas, J., Budnik, I., Shenkman, B., Hayami, H., Koide, Y., Goto, T., Iqbal, R., Alhamdi, Y., Venugopal, N., Abrams, S., Downey, C., Toh, C. H., Welters, I. D., Bombay, V. B., Chauny, J. M., Daoust, R. D., Lessard, J. L., Marquis, M. M., Paquet, J. P., Siemens, K., Sangaran, D., Hunt, B. J., Durward, A., Nyman, A., Murdoch, I. A., Tibby, S. M., Ampatzidou, F., Moisidou, D., Dalampini, E., Nastou, M., Vasilarou, E., Kalaizi, V., Chatzikostenoglou, H., Drossos, G., Spadaro, S., Fogagnolo, A., Fiore, T., Schiavi, A., Fontana, V., Taccone, F., Volta, C., Chochliourou, E., Volakli, E., Violaki, A., Samkinidou, E., Evlavis, G., Panagiotidou, V., Sdougka, M., Mothukuri, R., Battle, C., Guy, K., Wijesuriya, J., Keogh, S., Docherty, A., O’Donnell, R., Brunskill, S., Trivella, M., Doree, C., Holst, L., Parker, M., Gregersen, M., Almeida, J., Walsh, T., Stanworth, S., Moravcova, S., Mansell, J., Rogers, A., Smith, R. A., Hamilton-Davies, C., Omar, A., Allam, M., Bilala, O., Kindawi, A., Ewila, H., Malamas, A., Ferreira, G., Caldas, J., Fukushima, J., Osawa, E. A., Arita, E., Camara, L., Zeferino, S., Jardim, J., Gaioto, F., Dallan, L., Jatene, F. B., Kalil Filho, R., Galas, F., Hajjar, L. A., Mitaka, C., Ohnuma, T., Murayama, T., Kunimoto, F., Nagashima, M., Takei, T., Tomita, M., Mahmoud, K., Hanoura, S., Sudarsanan, S., Sivadasan, P., Othamn, H., Shouman, Y., Singh, R., Al Khulaifi, A., Mandel, I., Mikheev, S., Suhodolo, I., Kiselev, V., Svirko, Y., Podoksenov, Y., Jenkins, S. A., Griffin, R., Tovar Doncel, M. S., Lima, A., Aldecoa, C., Ince, C., Taha, A., Shafie, A., Mostafa, M., Syed, N., Hon, H., Righetti, F., Colombaroli, E., Castellano, G., Hravnak, M., Chen, L. C., Dubrawski, A. D., Clermont, G. C., Pinsky, M. R., Gonzalez, S., Macias, D., Acosta, J., Jimenez, P., Loza, A., Lesmes, A., Lucena, F., Leon, C., Bastide, M., Richecoeur, J., Frenoy, E., Lemaire, C., Sauneuf, B., Tamion, F., Nseir, S., Du Cheyron, D., Dupont, H., Maizel, J., Shaban, M., Kolko, R., AbuRageila, M., AlHussain, A., Mercado, P., Kontar, L., Titeca, D., Brazier, F., Riviere, A., Joris, M., Soupison, T., De Cagny, B., Slama, M., Wagner, J., Körner, A., Kubik, M., Kluge, S., Reuter, D., Saugel, B., Tran, T., De Bels, D., Cudia, A., Strachinaru, M., Ghottignies, P., Devriendt, J., Pierrakos, C., Martínez González, Ó., Blancas, R., Luján, J., Ballesteros, D., Martínez Díaz, C., Núñez, A., Martín Parra, C., López Matamala, B., Alonso Fernández, M., Chana, M., Huber, W., Eckmann, M., Elkmann, F., Gruber, A., Klein, I., Schmid, R. M., Lahmer, T., Moller, P. W., Sondergaard, S., Jakob, S. M., Takala, J., Berger, D., Bastoni, D., Aya, H., Toscani, L., Pigozzi, L., Rhodes, A., Cecconi, M., Ostrowska, C., Abbas, A., Mellinghoff, J., Ryan, C., Dawson, D., Cronhjort, M., Wall, O., Nyberg, E., Zeng, R., Svensen, C., Mårtensson, J., Joelsson-Alm, E., Parenti, N., Palazzi, C., Amidei, L. A., Borrelli, F. B., Campanale, S. C., Tagliazucchi, F. T., Sedoni, G. S., Lucchesi, D. L., Carella, E. C., Luciani, A. L, Mackovic, M., Maric, N., Bakula, M., Grounds, R. M., Fletcher, N., Avard, B., Zhang, P., Mezidi, M., Charbit, J., Ould-Chikh, M., Deras, P., Maury, C., Martinez, O., Capdevila, X., Hou, P., Linde-Zwirble, W. Z., Douglas, I. D., Shapiro, N. S., Ben Aicha, Y., Laribi, B., Jeribi, B., Pereira, C., Marinho, R., Antunes, R., Marinho, A., Crivits, M., Raes, M., Decruyenaere, J., Hoste, E., Bagin, V., Rudnov, V., Savitsky, A., Astafyeva, M., Korobko, I., Vein, V., Kampmeier, T., Arnemann, P., Hessler, M., Wald, A., Bockbreder, K., Morelli, A., Van Aken, H., Rehberg, S., Ertmer, C., Reddy, S., Bailey, M., Beasley, R., Bellomo, R., Mackle, D., Psirides, A., Young, P., Venkatesh, H., Ramachandran, S., Basu, A., Nair, H., Egan, S., Bates, J., Oliveira, S., Rangel Neto, N. R., Reis, F. Q., Lee, C. P., Lin, X. L., Choong, C., Eu, K. M., Sim, W. Y., Tee, K. S., Pau, J., Abisheganaden, J., Maas, K., De Geus, H., Lafuente, E., Moura, J., Doris, T. E., Monkhouse, D., Shipley, T., Kardasz, S., Gonzalez, I, Stads, S., Groeneveld, A. J., Elsayed, I., Ward, N., Raithatha, A., Steuber, A., Pelletier, C., Schroeder, S., Michael, E., Slowinski, T., Kindgen-Milles, D., Ghabina, S., Turani, F., Belli, A., Busatti, S., Barettin, G., Candidi, F., Gargano, F., Barchetta, R., Falco, M., Demirkiran, O., Kosuk, M., Bozbay, S., Weber, V., Hartmann, J., Harm, S., Linsberger, I., Eichhorn, T., Valicek, G., Miestinger, G., Hoermann, C., Faenza, S., Ricci, D., Mancini, E., Gemelli, C., Cuoghi, A., Magnani, S., Atti, M., Laddomada, T., Doronzio, A., Balicco, B., Gruda, M. C., O’Sullivan, P., Dan, V. P., Guliashvili, T., Scheirer, A., Golobish, T. D., Capponi, V. J., Chan, P. P., Kogelmann, K., Drüner, M., Jarczak, D., Belli, A. B., Martni, S. M., Cotticelli, V. C., Mounajergi, F., Morimoto, S., Hussain, I., Nadeem, A., Ghorab, K., Maghrabi, K., Kloesel, S. K., Goldfuss, C., Stieglitz, A., Stieglitz, A. S., Krstevska, L., Albuszies, G., Jimmy, G., Izawa, J., Iwami, T., Uchino, S., Takinami, M., Kitamura, T., Kawamura, T., Powell-Tuck, J. G., Crichton, S., Raimundo, M., Camporota, L., Wyncoll, D., Ostermann, M., Hana, A., De Geus, H. R., Aydogdu, M., Boyaci, N., Yuksel, S., Gursel, G., Cayci Sivri, A. B., Meza-Márquez, J., Nava-López, J., Carrillo-Esper, R., Dardashti, A., Grubb, A., Wetzstein, M., Peters, E., Njimi, H., Pickkers, P., Waraich, M., Doyle, J., Samuels, T., Forni, L., Desai, N., Baumber, R., Gunning, P., Sell, A., Lin, S., Torrence, H., O’Dwyer, M., Kirwan, C., Prowle, J., Kim, T., O’Connor, M. E., Hewson, R. W., Kirwan, C. J., Pearse, R. M., Maksoud, M., Uzundere, O., Memis, D., Ýnal, M., Gultekin, A., Turan, N., Aydin, M. A., Basar, H., Sencan, I., Kapuagasi, A., Ozturk, M., Uzundurukan, Z., Gokmen, D., Ozcan, A., Kaymak, C., Artemenko, V. A., Budnyuk, A., Pugh, R., Bhandari, S., Mauri, T., Turrini, C., Langer, T., Taccone, P., Volta, C. A., Marenghi, C., Gattinoni, L., Pesenti, A., Sweeney, L., O’Sullivan, A., Kelly, P., Mukeria, E., MacLoughlin, R., Pfeffer, M., Thomas, J. T., Bregman, G. B., Karp, G. K., Kishinevsky, E. K., Stavi, D. S., Adi, N. A., Poropat, T., Knafelj, R., Llopart, E., Batlle, M., De Haro, C., Mesquida, J., Artigas, A., Pavlovic, D., Lewerentz, L., Spassov, A., Schneider, R., De Smet, S., De Raedt, S., Derom, E., Depuydt, P, Oeyen, S., Benoit, D., Gobatto, A., Besen, B., Tierno, P., Melro, L., Mendes, P., Cadamuro, F., Park, M., Malbouisson, L. M., Civantos, B. C., Lopez, J. L., Robles, A., Figueira, J., Yus, S., Garcia, A., Oglinda, A., Ciobanu, G., Oglinda, C., Schirca, L., Sertinean, T., Lupu, V., Wolny, M., Pagano, A., Numis, F., Visone, G., Saldamarco, L., Russo, T., Porta, G., Paladino, F., Bell, C., Liu, J., Debacker, J., Lee, C., Tamberg, E., Campbell, V., Mehta, S., Kara, Ý., Yýldýrým, F., Zerman, A., Güllü, Z., Boyacý, N., Basarýk Aydogan, B., Gaygýsýz, Ü., Gönderen, K., Arýk, G., Turkoglu, M., Aygencel, G., Ülger, Z., Isýkdogan, Z., Özdedeoglu, Ö., Badoglu, M., Gaygýsýz, U., Kongpolprom, N., Sittipunt, C., Eden, A., Kokhanovsky, Y., Bursztein – De Myttenaere, S., Pizov, R., Neilans, L., MacIntyre, N., Radosevich, M., Wanta, B., Meyer, T., Smischney, N., Brown, D., Diedrich, D., Fuller, A., McLindon, P., Sim, K., Shoaeir, M., Noeam, K., Mahrous, A., Matsa, R., Ali, A., Dridi, C., Haddad, F., Pérez-Calatayud, A., Zepeda-Mendoza, A., Diaz-Carrillo, M., Arch-Tirado, E., Carbognin, S., Pelacani, L., Zannoni, F., Agnoli, A., Gagliardi, G., Cho, R., Adams, A., Lunos, S., Ambur, S., Shapiro, R., Prekker, M., Thijssen, M., Janssen, L., Foudraine, N., Voscopoulos, C. J., Freeman, J., George, E., Eversole, D., Muttini, S., Bigi, R., Villani, G., Patroniti, N., Williams, G., George, E, Waldmann, A., Böhm, S., Windisch, W., Strassmann, S., Karagiannidis, C., Karagiannidis, C. K., Waldmann, A. W., Böhm, S. B., Windisch, W. W., Persson, P., Lundin, S., Stenqvist, O., Serra, C. S., Pagano, A. P., Masarone, M. M., Rinaldi, L. R., Amelia, A. A., Fascione, M. F., Adinolfi, L. A., Ruggiero, E. R., Asota, F., O’Rourke, K., Ranjan, S., Morgan, P., DeBacker, J. W., O’Neill, L., Munshi, L., Burry, L., Fan, E., Poo, S., Mahendran, K., Fowles, J., Gerrard, C., Vuylsteke, A., Loveridge, R., Chaddock, C., Patel, S., Kakar, V., Willars, C., Hurst, T., Park, C., Best, T., Vercueil, A., Auzinger, G., Borgman, A., Proudfoot, A. G., Grins, E., Emiley, K. E., Schuitema, J., Fitch, S. J., Marco, G., Sturgill, J., Dickinson, M. G., Strueber, M., Khaghani, A., Wilton, P., Jovinge, S. M., Sampson, C., Harris-Fox, S., Cove, M. E., Vu, L. H., Sen, A., Federspiel, W. J., Kellum, J. A., Mazo Torre, C., Riera, J., Ramirez, S., Borgatta, B., Lagunes, L., Rello, J., Kuzovlev, A. K., Goloubev, A., Nenchuk, S., Karavana, V., Glynos, C., Asimakos, A., Pappas, K., Vrettou, C., Magkou, M., Ischaki, E., Stathopoulos, G., Zakynthinos, S., Kozhevnikova, I., Dalla Corte, F., Grasso, S., Casolari, P., Caramori, G., Andrianjafiarinoa, T., Randriamandrato, T., Rajaonera, T., El-Dash, S., Costa, E. L. V., Tucci, M. R., Leleu, F, Kontar, L, Bacari-Risal, G., Amato, M., El Dash, S., Remmington, Fischer, A., Squire, S., Boichat, M., Honzawa, H., Yasuda, H., Adati, T., Suzaki, S., Horibe, M., Sasaki, M., Sanui, M., Daniel, J., Miranda, H., Milinis, K., Cooper, M., Williams, G. R., McCarron, E., Simants, S., Patanwala, I., Welters, I., Su, Y., Fernández Villanueva, J., Fernández Garda, R., López Lago, A., Rodríguez Ruíz, E., Hernández Vaquero, R., Tomé Martínez de Rituerto, S., Varo Pérez, E., Lefel, N., Schaap, F., Bergmans, D., Olde Damink, S., Van de Poll, M., Tizard, K., Lister, C., Poole, L., Ringaitiene, D., Gineityte, D., Vicka, V., Norkiene, I., Sipylaite, J., O’Loughlin, A., Maraj, V., Dowling, J., Velasco, M. B., Dalcomune, D. M., Dias, E. B., Fernandes, S. L., Oshima, T., Graf, S., Heidegger, C., Genton, L., Karsegard, V., Dupertuis, Y., Pichard, C., Friedli, N., Stanga, Z., Vandersteen, L., Stessel, B., Evers, S., Van Assche, A., Jamaer, L., Dubois, J., Castro, H., Valente, J., Martins, P., Casteloes, P., Magalhaes, C., Cabral, S., Santos, M., Oliveira, B., Salgueiro, A., Duarte, S., Castro, S., Melo, M., Gray, S., Maipang, K., Bhurayanontachai, R., Grädel, L. G., Schütz, P., Langlois, P., Manzanares, W., Lemieux, M., Elke, G., Bloos, F., Heyland, D., Aramendi, I., Babo, N., Hoshino, M., Haraguchi, Y., Kajiwara, S., Mitsuhashi, T., Tsubata, T., Aida, M., Rattanapraphat, T., Kongkamol, C., Xavier, B., Koutsogiannidis, C., Moschopoulou, M., Taskin, G., Çakir, M., Güler, AK, Taskin, A., Öcal, N., Özer, S., Yamanel, L., Wong, J. M., Fitton, C., Anwar, S., Stacey, S., Aggou, M., Fyntanidou, B., Patsatzakis, S., Oloktsidou, E., Lolakos, K., Papapostolou, E., Grosomanidis, V., Gaudry, S., Desailly, V., Pasquier, P., Brun, PB, Tesnieres, AT, Ricard, JD, Dreyfuss, D., Mignon, A., White, J. C, Stilwell, A., Friedlaender, G., Peters, M., Stipulante, S., Delfosse, A., Donneau, AF, Ghuysen, A., Feldmann, C., Freitag, D., Dersch, W., Irqsusi, M., Eschbach, D., Steinfeldt, T., Wulf, H., Wiesmann, T., Cholkraisuwat, J., Beitland, S., Nakstad, E., Stær-Jensen, H., Drægni, T., Andersen, G., Jacobsen, D., Brunborg, C., Waldum-Grevbo, B., Sunde, K., Hoyland, K., Pandit, D., Hayakawa, K., Kotzampassi, K., Loukipoudi, L., Doumaki, E., Admiraal, M. M., Van Assen, M., Van Putten, M. J., Tjepkema-Cloostermans, M., Van Rootselaar, A. F., Ragusa, F., Marudi, A., Baroni, S., Gaspari, A., Bertellini, E., Abdullah, T., Abdel Monem, S., Alcorn, S., McNeill, S., Russell, S., Eertmans, W., Genbrugge, C., Meex, I., Dens, J., Jans, F., De Deyne, C., Avard, B, Burns, R, Patarchi, A., Spina, T., Tanaka, H., Otani, N., Ode, S., Ishimatsu, S., Cho, J., Moon, J. B., Park, C. W., Ohk, T. G., Shin, M. C., Won, M. H., Dakova, S., Ramsheva, Z., Ramshev, K., Marudi, A, Baroni, S, Gaspari, A, Bertellini, E, Ozcan, P. E., Sencer, S., Ulusoy, C., Fallenius, M., Skrifvars, M. B., Reinikainen, M., Bendel, S., Raj, R., Abu-Habsa, M., Hymers, C., Borowska, A., Sivadhas, H., Sahiba, S., Perkins, S., Rubio, J., Rubio, J. A., Sierra, R., English, S., Chasse, M., Turgeon, A., Lauzier, F., Griesdale, D., Garland, A., Fergusson, D., Zarychanski, R., Tinmouth, A., Van Walraven, C., Montroy, K., Ziegler, J., Dupont Chouinard, R., Carignan, R., Dhaliwal, A., Lum, C., Sinclair, J., Pagliarello, G., McIntyre, L., Groza, T., Moreau, N., Castanares-Zapatero, D., Hantson, P., Carbonara, M., Ortolano, F., Zoerle, T., Magnoni, S., Pifferi, S., Conte, V., Stocchetti, N., Carteron, L., Suys, T., Patet, C., Quintard, H., Oddo, M., Spatenkova, V., Pokorna, E., Suchomel, P., Ebert, N., Bylinski, T., Hawthorne, C., Shaw, M., Piper, I., Kinsella, J., Kink, A. K., Rätsep, I. R., Boutin, A., Moore, L., Lacroix, J., Lessard-Bonaventure, P., Turgeon, A. F., Green, R., Erdogan, M., Butler, M., Desjardins, P., Fergusson, D. A., Goncalves, B., Vidal, B., Valdez, C., Rodrigues, A. C., Miguez, L., Moralez, G., Hong, T., Kutz, A., Hausfater, P., Amin, D., Struja, T., Haubitz, S., Huber, A., Brown, T., Collinson, J., Pritchett, C., Slade, T., Le Guen, M., Hellings, S., Ramsaran, R., Alsheikhly, A., Abe, T., Kanapeckaite, L., Bahl, R., Russell, M. Q., Real, K. J., Lyon, R. M., Oveland, N. P., Penketh, J., Mcdonald, M., Kelly, F., Alfafi, M., Almutairi, W., Alotaibi, B., Van den Berg, A. E, Schriel, Y., Dawson, L., Meynaar, I. A., Silva, D., Fernandes, S., Gouveia, J., Santos Silva, J., Foley, J., Kaskovagheorgescu, A., Evoy, D., Cronin, J., Ryan, J., Huck, M., Hoffmann, C., Renner, J., Laitselart, P., Donat, N., Cirodde, A., Schaal, J. V., Masson, Y., Nau, A., Howarth, O., Davenport, K., Jeanrenaud, P., Raftery, S., MacTavish, P., Devine, H., McPeake, J., Daniel, M., Quasim, T., Alrabiee, S., Alrashid, A., Gundogan, O., Bor, C., Akýn Korhan, E., Demirag, K., Uyar, M., Frame, F., Ashton, C., Bergstrom Niska, L., Dilokpattanamongkol, P., Suansanae, T., Suthisisang, C., Morakul, S., Karnjanarachata, C., Tangsujaritvijit, V., Mahmood, S., Al Thani, H., Almenyar, A., Morton, S. E., Chiew, Y. S., Pretty, C., Chase, J. G., Shaw, G. M., Kordis, P., Grover, V., Kuchyn, I., Bielka, K., Aidoni, Z., Stavrou, G., Skourtis, C., Lee, S. D., Williams, K., Weltes, I. D., Berhane, S., Arrowsmith, C., Peters, C., Robert, S., Panerai, R. B., Robinson, T. G., Borg-Seng-Shu, E., De Lima Oliveira, M., Mian, N. C., Nogueira, R., Zeferino, S. P., Jacobsen Teixeira, M., Killeen, P., McPhail, M., Bernal, W., Maggs, J., Wendon, J., Hughes, T., Taniguchi, L. U., Siqueira, E. M., Vieira Jr, J. M., Azevedo, L. C., Ahmad, A. N., Helme, E., Hadfield, S., Shak, J., Senver, C., Howard-Griffin, R., Wacharasint, P., Fuengfoo, P., Sukcharoen, N., Rangsin, R., Sbiti-Rohr, D., Na, H., Song, S., Lee, S., Jeong, E., Lee, K., Zoumpelouli, E., Volakli, E. A, Chrysohoidou, V., Charisopoulou, K., Kotzapanagiotou, E., Manavidou, K., Stathi, Z., AlGhamdi, B., Marashly, Q., Zaza, K., Khurshid, M., Ali, Z., Malgapo, M., Jamil, M., Shafquat, A., Shoukri, M., Hijazi, M., Rocha, F. A., Ebecken, K., Rabello, L. S., Lima, M. F., Hatum, R., De Marco, F. V., Alves, A., Pinto, J. E., Godoy, M., Brasil, P. E., Bozza, F. A., Salluh, J. I., Soares, M., Krinsley, J., Kang, G., Perry, J., Hines, H., Wilkinson, K. M., Tordoff, C., Sloan, B., Bellamy, M. C., Moreira, E., Verga, F., Barbato, M., Burghi, G., Soares, M, Silva, U. V., Torelly, A. P., Kahn, J. M., Angus, D. C., Knibel, M. F., Marshall, R., Gilpin, T., Mota, D., Loureiro, B., Dias, J., Afonso, O., Coelho, F., Martins, A., Faria, F., Al Orainni, H., AlEid, F., Tlaygeh, H., Itani, A., Hejazi, A., Messika, J., Ricard, J. D., Guillo, S., Pasquet, B., Dubief, E., Tubach, F., James, K., Temblett, P., Davies, L., Lynch, C., Pereira, S., Cavaco, S., Fernandes, J., Moreira, I., Almeida, E., Seabra Pereira, F., Malheiro, M., Cardoso, F., Aragão, I., Cardoso, T., Fister, M., Muraray Govind, P., Brahmananda Reddy, N., Pratheema, R., Arul, E. D., Devachandran, J., Chin-Yee, N., D’Egidio, G., Thavorn, K., Kyeremanteng, K., Murchison, A. G., Swalwell, K., Mandeville, J., Stott, D., Guerreiro, I., Goossens, C., Marques, M. B., Derde, S., Vander Perre, S., Dufour, T., Thiessen, S. E., Güiza, F., Janssens, T., Hermans, G., Vanhorebeek, I., De Bock, K., Van den Berghe, G., Langouche, L., Miles, B., Madden, S., Weiler, M., Marques, P., Rodrigues, C., Boeira, M., Brenner, K., Leães, C., Machado, A., Townsend, R., Andrade, J., Kishore, R., Fenlon, C., Fiks, T., Ruijter, A., Te Raa, M., Spronk, P., Docherty, P., Dickson, J., Moltchanova, E., Scarrot, C., Hall, T., Ngu, W. C., Jack, J. M., Pavli, A., Gee, X., Akin Korhan, E., Shirazy, M., Fayed, A., Gupta, S., Kaushal, A., Dewan, S., Varma, A., Ghosh, E., Yang, L., Eshelman, L., Lord, B., Carlson, E., Broderick, R., Ramos, J., Forte, D., Yang, F., Feeney, J., Wilkinson, K., Shuker, K., Faulds, M., Bryden, D., England, L., Shuker, K, Tridente, A, Faulds, M, Matheson, A, Gaynor, J., Bryden, D, Peroni, B., Daglius-Dias, R., Miranda, L., Cohen, C., Carvalho, C., Velasco, I., Kelly, J. M., Neill, A., Rubenfeld, G., Masson, N., Min, A., Boezeman, E., Hofhuis, J., Hovingh, A., De Vries, R., Cabral-Campello, G., Van Mol, M., Nijkamp, M., Kompanje, E., Ostrowski, P., Kiss, K., Köves, B., Csernus, V., Molnár, Z., Hoydonckx, Y., Vanwing, S., Medo, V., Galvez, R., Miranda, J. P., Stone, C., Wigmore, T., Arunan, Y., Wheeler, A., Wong, Y., Poi, C., Gu, C., Molmy, P., Van Grunderbeeck, N., Nigeon, O., Lemyze, M., Thevenin, D., Mallat, J., Correa, M., Carvalho, R. T., Fernandez, A., McBride, C., Koonthalloor, E., Walsh, C., Webber, A., Ashe, M., Smith, K., Volakli, E. A., Dimitriadou, M., Mantzafleri, P., Vrani, O., Arbouti, A., Varsami, T., Bollen, J. A., Van Smaalen, T. C., De Jongh, W. C., Ten Hoopen, M. M., Ysebaert, D., Van Heurn, L. W., Van Mook, W. N., Roze des Ordons, A., Couillard, P., Doig, C., Van Keer, R. V., Deschepper, R. D., Francke, A. F., Huyghens, L. H., Bilsen, J. B., Nyamaizi, B., Dalrymple, C., Dobru, A., Marrinan, E., Ankuli, A., Struthers, R., Crawford, R., Mactavish, P., Morelli, P., Degiovanangelo, M., Lemos, F., MArtinez, V., Cabrera, J., Rutten, A., Van Ieperen, S., De Geer, S., Van Vugt, M., Der Kinderen, E., Giannini, A., Miccinesi, G, Marchesi, T, and Prandi, E more...
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Protocol (science) ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,French ,030208 emergency & critical care medicine ,Compression (physics) ,Critical Care and Intensive Care Medicine ,Meeting Abstracts ,language.human_language ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,law ,Ventilation (architecture) ,Emergency medicine ,language ,Medicine ,030212 general & internal medicine ,Cardiopulmonary resuscitation ,business - Abstract
Table of contents P001 - Sepsis impairs the capillary response within hypoxic capillaries and decreases erythrocyte oxygen-dependent ATP efflux R. M. Bateman, M. D. Sharpe, J. E. Jagger, C. G. Ellis P002 - Lower serum immunoglobulin G2 level does not predispose to severe flu. J. Solé-Violán, M. López-Rodríguez, E. Herrera-Ramos, J. Ruíz-Hernández, L. Borderías, J. Horcajada, N. González-Quevedo, O. Rajas, M. Briones, F. Rodríguez de Castro, C. Rodríguez Gallego P003 - Brain protective effects of intravenous immunoglobulin through inhibition of complement activation and apoptosis in a rat model of sepsis F. Esen, G. Orhun, P. Ergin Ozcan, E. Senturk, C. Ugur Yilmaz, N. Orhan, N. Arican, M. Kaya, M. Kucukerden, M. Giris, U. Akcan, S. Bilgic Gazioglu, E. Tuzun P004 - Adenosine a1 receptor dysfunction is associated with leukopenia: A possible mechanism for sepsis-induced leukopenia R. Riff, O. Naamani, A. Douvdevani P005 - Analysis of neutrophil by hyper spectral imaging - A preliminary report R. Takegawa, H. Yoshida, T. Hirose, N. Yamamoto, H. Hagiya, M. Ojima, Y. Akeda, O. Tasaki, K. Tomono, T. Shimazu P006 - Chemiluminescent intensity assessed by eaa predicts the incidence of postoperative infectious complications following gastrointestinal surgery S. Ono, T. Kubo, S. Suda, T. Ueno, T. Ikeda P007 - Serial change of c1 inhibitor in patients with sepsis – A prospective observational study T. Hirose, H. Ogura, H. Takahashi, M. Ojima, J. Kang, Y. Nakamura, T. Kojima, T. Shimazu P008 - Comparison of bacteremia and sepsis on sepsis related biomarkers T. Ikeda, S. Suda, Y. Izutani, T. Ueno, S. Ono P009 - The changes of procalcitonin levels in critical patients with abdominal septic shock during blood purification T. Taniguchi, M. O P010 - Validation of a new sensitive point of care device for rapid measurement of procalcitonin C. Dinter, J. Lotz, B. Eilers, C. Wissmann, R. Lott P011 - Infection biomarkers in primary care patients with acute respiratory tract infections – Comparison of procalcitonin and C-reactive protein M. M. Meili, P. S. Schuetz P012 - Do we need a lower procalcitonin cut off? H. Hawa, M. Sharshir, M. Aburageila, N. Salahuddin P013 - The predictive role of C-reactive protein and procalcitonin biomarkers in central nervous system infections with extensively drug resistant bacteria V. Chantziara, S. Georgiou, A. Tsimogianni, P. Alexandropoulos, A. Vassi, F. Lagiou, M. Valta, G. Micha, E. Chinou, G. Michaloudis P014 - Changes in endotoxin activity assay and procalcitonin levels after direct hemoperfusion with polymyxin-b immobilized fiber A. Kodaira, T. Ikeda, S. Ono, T. Ueno, S. Suda, Y. Izutani, H. Imaizumi P015 - Diagnostic usefullness of combination biomarkers on ICU admission M. V. De la Torre-Prados, A. Garcia-De la Torre, A. Enguix-Armada, A. Puerto-Morlan, V. Perez-Valero, A. Garcia-Alcantara P016 - Platelet function analysis utilising the PFA-100 does not predict infection, bacteraemia, sepsis or outcome in critically ill patients N. Bolton, J. Dudziak, S. Bonney, A. Tridente, P. Nee P017 - Extracellular histone H3 levels are inversely correlated with antithrombin levels and platelet counts and are associated with mortality in sepsis patients G. Nicolaes, M. Wiewel, M. Schultz, K. Wildhagen, J. Horn, R. Schrijver, T. Van der Poll, C. Reutelingsperger P018 - Il-8: is this a more reliable biomarker for sepsis severity than CRP, Procalcitonin, E-selectin, IL-6 and TNF-[alpha] S. Pillai, G. Davies, G. Mills, R. Aubrey, K. Morris, P. Williams, P. Evans P019 - Relation between adrenomedullin and short-term outcome in ICU patients: Results from the frog ICU study E. G. Gayat, J. Struck, A. Cariou, N. Deye, B. Guidet, S. Jabert, J. Launay, M. Legrand, M. Léone, M. Resche-Rigon, E. Vicaut, A. Vieillard-Baron, A. Mebazaa P020 - Impact of disease severity assessment on performance of heparin-binding protein for the prediction of septic shock R. Arnold, M. Capan, A. Linder, P. Akesson P021 - Kinetics and prognostic value of presepsin (sCD14) in septic patients. A pilot study M. Popescu, D. Tomescu P022 - Comparison of CD64 levels performed by the facs and accellix systems C. L. Sprung, R. Calderon Morales, G. Munteanu, E. Orenbuch-Harroch, P. Levin, H. Kasdan, A. Reiter, T. Volker, Y. Himmel, Y. Cohen, J. Meissonnier P023 - Diagnosing sepsis in 5 minutes: Nanofluidic technology study with pancreatic-stone protein (PSP/ reg) L. Girard, F. Rebeaud P024 - How nanotechnology-based approaches could contribute to sepsis prevention, diagnosis and treatment I. Herrmann P025 - Il7r transcriptional expression analysis during septic shock B. Delwarde, E. Peronnet, E. Cerrato, F. Venet, A. Lepape, T. Rimmelé, G. Monneret, J. Textoris P026 - Disbalance of microbial metabolites of aromatic acids affects the severity in critically ill patients N. Beloborodova, V. Moroz, A. Osipov, A. Bedova, Y. Sarshor, A. Pautova, A. Sergeev, E. Chernevskaya P027 - Copeptin predicts 10-year all-cause mortality in community patients J. Odermatt, R. Bolliger, L. Hersberger, M. Ottiger, M. Christ-Crain, B. Mueller, P. Schuetz P028 - Identification of differential proteomic response in septic patients secondary to community and hospital acquired pneumonia N. K. Sharma, A. K. Tashima, M. K. Brunialti, F. R. Machado, M. Assuncao, O. Rigato, R. Salomao P029 - Monocyte HLA-DR expression in community-acquired bacteremic sepsis - dynamics associated to aetiology and prediction of secondary sepsis S. C. Cajander, G. Rasmussen, E. Tina, B. Söderquist, J. Källman, K. Strålin P030 - Soluble B- and T-lymphocyte attenuator: A possible prognostic marker in sepsis A. L. Lange, J. S. Sundén-Cullberg, A. M. Magnuson, O. H. Hultgren P031 - Fractal dimension: A new biomarker for quantifying clot microstructure in patients across the sepsis spectrum G. Davies, S. Pillai, G. Mills, R. Aubrey, K. Morris, P. Williams, P. Evans P032 - Comparison between the new biomarker for coagulation, clot microstructure (Df) with rotational thromboelastometry (ROTEM) in patients across the sepsis spectrum S. Pillai, G. Davies, G. Mills, R. Aubrey, K. Morris, P. Williams, P. Evans P033 - Changes in fibrinolysis across the sepsis spectrum: The use of rotational thromboelastometry (ROTEM) lysis index (LI60) and D-Dimer concentration S. Pillai, G. Davies, G. Mills, R. Aubrey, K. Morris, P. Williams, P. Evans P034 - The intensive care infection score – a promising marker for the prediction of infection and its severity. P. Van der Geest, M. Mohseni, J. Linssen, R. De Jonge, S. Duran, J. Groeneveld P035 - Challenges in the clinical diagnosis of sepsis R. Miller III, B. K. Lopansri, L. C. McHugh, A. Seldon, J. P. Burke P036 - Does zero heat flux thermometry more accurately identify sepsis on intensive care? J. Johnston, R. Reece-Anthony, A. Bond, A. Molokhia P037 - Advancing quality (AQ) sepsis programme: Improving early identification & treatment of sepsis in North West England. C. Mcgrath, E. Nsutebu P038 - Prehospital transport of acute septic patients P. Bank Pedersen, D. Pilsgaard Henriksen, S. Mikkelsen, A. Touborg Lassen P039 - Vasodilatory plant extracts gel as an alternative treatment for fever in critically ill patients R. Tincu, C. Cobilinschi, D. Tomescu, Z. Ghiorghiu, R. Macovei P040 - Host response and outcome of hypothermic sepsis M. A. Wiewel, M. B. Harmon, L. A. Van Vught, B. P. Scicluna, A. J. Hoogendijk, J. Horn, A. H. Zwinderman, O. L. Cremer, M. J. Bonten, M. J. Schultz, T. Van der Poll, N. P. Juffermans, W. J. Wiersinga P041 - Septic shock alert over SIRS criteria has an impact on outcome but needs to be revised G. Eren, Y Tekdos, M. Dogan, O. Acicbe, E. Kaya, O. Hergunsel P042 - Association between previous prescription of βblockers and mortality rate among septic patients: A retrospective observational study S. Alsolamy, G. Ghamdi, L. Alswaidan, S. Alharbi, F. Alenezi, Y. Arabi P043 - Recognition and treatment of sepsis on labour ward– teaching & information resources can improve knowledge J. Heaton, A. Boyce, L. Nolan, J. Johnston, A. Dukoff-Gordon, A. Dean, A. Molokhia P044 - Culture negative sepsis in the ICU – what is unique to this patient population? T. Mann Ben Yehudah P045 - Organ dysfunction in severe sepsis patients identified in administrative data in Germany, 2007-2013 C. Fleischmann, D. Thomas-Rueddel, C. Haas, U. Dennler, K. Reinhart P046 - A comparison of residents’ knowledge regarding; the Surviving Sepsis Campaign 2012 guideline O. Suntornlohanakul, B. Khwannimit P047 - Effectiveness of a septic shock bundle to improve outcomes in the ICU F. Breckenridge, A. Puxty P048 - Dose of norepinephrine in the first 24 hours as a parameter evaluating the effectiveness of treatment in patients with severe sepsis and septic shock P. Szturz, P. Folwarzcny, J. Svancara, R. Kula, P. Sevcik P049 - Norepinephrine or vasopressin + norepinephrine in septic shock. A retrospective series of 39 patients L. Caneva, A. Casazza, E. Bellazzi, S. Marra, L. Pagani, M. Vetere, R. Vanzino, D. Ciprandi, R. Preda, R. Boschi, L. Carnevale P050 - Methylene blue effectiveness as contributory treatment in patients with septic shock V. Lopez, M. Aguilar Arzapalo, L. Barradas, A. Escalante, J. Gongora, M. Cetina P051 - Coagulation disorders in patients with severe sepsis and DIC evaluated with thromboelastometry. B Adamik, D Jakubczyk, A Kübler P052 - Frequency and outcome of early sepsis-associated coagulopathy A. Radford, T. Lee, J. Singer, J. Boyd, D. Fineberg, M. Williams, J. Russell P053 - Assessment of coagulopathy in cancer patients with severe sepsis or septic shock. A case-control pilot study E. Scarlatescu, D. Tomescu, G. Droc, S. Arama P054 - Thromboelastometry in critically ill patients with disseminated intravascular coagulation M. Müller, M. Straat, S. S. Zeerleder, N. P. Juffermans P055 - Cessation of a preexisting chronic antiplatelet therapy is associated with increased mortality rates in severe sepsis and septic shock C. F. Fuchs, C. S. Scheer, S. W. Wauschkuhn, M. V. Vollmer, K. M. Meissner, S. K. Kuhn, K. H. Hahnenkamp, S. R. Rehberg, M. G. Gründling P056 - Neutrophil Extracellular Traps (NETs) production under hypoxic condition N. Yamamoto, M. Ojima, S. Hamaguchi, T. Hirose, Y. Akeda, R. Takegawa, O. Tasaki, T. Shimazu, K. Tomono P057 - Impact of ultraviolet air sterilizer in intensive care unit room, and clinical outcomes of patients E. Gómez-Sánchez, M. Heredia-Rodríguez, E. Álvarez-Fuente, M. Lorenzo-López, E. Gómez-Pesquera, M. Aragón-Camino, P. Liu-Zhu, A. Sánchez-López, A. Hernández-Lozano, M. T. Peláez-Jareño, E. Tamayo P058 - Focus of infection in severe sepsis - comparison of administrative data and prospective cohorts from Germany D. O. Thomas-Rüddel, C. Fleischmann, C. Haas, U. Dennler, K. Reinhart P059 - “Zero CLABSI” – can we get there? Obstacles on the 4 year journey and our strategies to overcome them – experience from an Indian ICU V. Adora, A. Kar, A. Chakraborty, S. Roy, A. Bandyopadhyay, M. Das P060 - Novel molecular techniques to identify central venous catheter (CVC) associated blood stream infections (BSIs) T. Mann Ben Yehudah, G. Ben Yehudah, M. Salim, N. Kumar, L. Arabi, T. Burger, P. Lephart, E. Toth-martin P061 - Zero clabsi” – can we get there? Obstacles on the 4 year journey and our strategies to overcome them – experience from an Indian ICU R. Rao, A. Kar, A. Chakraborty P062 - Prevention of central line-associated bloodstream infections in intensive care units: An international online survey C. Valencia, N. Hammami, S. Blot, J. L. Vincent, M. L. Lambert P063 - 30 days antimicrobial efficacy of non-leaching central venous catheters J. Brunke, T. Riemann, I. Roschke P064 - Efficacy of noble metal alloy-coated catheter in prevention of bacteriuria R. Tincu, C. Cobilinschi, D. Tomescu, Z. Ghiorghiu, R. Macovei P065 - Predicting bacteremic urinary tract infection in community setting: A prospective observational study S. Nimitvilai, K. Jintanapramote, S. Jarupongprapa P066 - Eight-year analysis of acinetobacter spp. monobacteremia in surgical and medical intensive care units at university hospital in Lithuania D. Adukauskiene, D. Valanciene P067 - Group A and group B streptococcal infections in intensive care unit – our experience in a tertiary centre G. Bose, V. Lostarakos, B. Carr P068 - Improved detection of spontaneous bacterial peritonitis by uritop + tm strip test and inoculation of blood culture bottles with ascitic fluid S. Khedher, A. Maaoui, A. Ezzamouri, M. Salem P069 - Increased risk of cellulitis in patients with congestive heart failure: a population based cohort study J. Chen P070 - Outcomes of severe cellulitis and necrotizing fasciitis in the critically ill D. R. Cranendonk, L. A. Van Vught, M. A. Wiewel, O. L. Cremer, J. Horn, M. J. Bonten, M. J. Schultz, T. Van der Poll, W. J. Wiersinga P071 - Botulism outbreak associated with people who inject drugs (PWIDs) in Scotland. M. Day, G. Penrice, K. Roy, P. Robertson, G. Godbole, B. Jones, M. Booth, L. Donaldson P072 - Surveillance of ESBL-producing enterobacteriaceae fecal carriers in the ICU Y. Kawano, H. Ishikura P073 - Prevalence of ESBL and carbapenemase producing uropathogens in a newly opened hospital in south India S. Sreevidya, N. Brahmananda Reddy, P. Muraray Govind, R. Pratheema, J. Devachandran Apollo Speciality Hospital - OMR, Chennai, India P074 - Prevalence, risk factors and outcomes of methicillin-resistant staphylococcus aureus nasal colonization in critically ill patients H. Al-Dorzi, M. Almutairi, B. Alhamadi, A. Crizaldo Toledo, R. Khan, B. Al Raiy, Y. Arabi P075 - Multidrug-resistant Acinetobacter baumannii infection in intensive care unit patients in a hospital with building construction: Is there an association? H. Talaie P076 - Multidrug-resistant organisms in a Dutch ICU J. A. Van Oers, A. Harts, E. Nieuwkoop, P. Vos P077 - Epidemiology and risk factors of ICU acquired infections caused by multidrug-resistant gram negative bacilli Y. Boussarsar, F. Boutouta, S. Kamoun, I. Mezghani, S. Koubaji, A. Ben Souissi, A. Riahi, M. S. Mebazaa P078 - Improving outcomes of severe infections by multidrug-resistant pathogens with polyclonal IgM-enriched immunoglobulins E. Giamarellos-Bourboulis, N. Tziolos, C. Routsi, C. Katsenos, I. Tsangaris, I. Pneumatikos, G. Vlachogiannis, V. Theodorou, A. Prekates, E. Antypa, V. Koulouras, N. Kapravelos, C. Gogos, E. Antoniadou, K. Mandragos, A. Armaganidis P079 - Must change the medical practice in ICU? A. R. Robles Caballero, B. Civantos, J. C. Figueira, J. López P080 - Mediterranean spotted fever in an infectious diseases intensive care unit A. Silva-Pinto, F. Ceia, A. Sarmento, L. Santos P081 - Clinical features and outcomes of patients with Middle East respiratory syndrome requiring admission to a saudi intensive care unit: A retrospective analysis of 31 cases G. Almekhlafi, Y. Sakr P082 - The ICU response to a hospital outbreak of Middle East respiratory syndrome coronavirus infection H. Al-Dorzi, R. Khan, S. Baharoon, A. Aldawood, A. Matroud, J. Alchin, S. Al Johani, H. Balkhy, Y. Arabi P083 - Middle East respiratory syndrome: Surveillance data analysis S. Alsolamy, S. Y. Yousif, B. O. Alotabi, A. S. Alsaawi P085 - Use of Taqman array card molecular diagnostics in severe pneumonia: A case series J. Ang, MD Curran, D. Enoch, V. Navapurkar, A. Conway Morris P086 - ‘BUNS’: An investigation protocol improves the ICU management of pneumonia R. Sharvill, J. Astin P087 - Pneumonia in patients following secondary peritonitis: epidemiological features and impact on mortality M. Heredia-Rodríguez, E. Gómez-Sánchez, M. T. Peláez-Jareño, E. Gómez-Pesquera, M. Lorenzo-López, P. Liu-Zhu, M. Aragón-Camino, A. Hernández-Lozano, A. Sánchez-López, E. Álvarez-Fuente, E. Tamayo P088 - The use of the “CURB-65 score” by emergency room clinicians in a large teaching hospital J. Patel, C. Kruger P089 - Incidence of community acquired pneumonia with viral infection in mechanically ventilated patients in the medical intensive care unit J. O’Neal, H. Rhodes, J. Jancik P090 - The SAATELLITE Study: Prevention of S aureus Nosocomial Pneumonia (NP) with MEDI4893, a Human Monoclonal Antibody (mAb) Against S aureus B. François, P. F. Laterre, P. Eggimann, A. Torres, M. Sánchez, P. F. Dequin, G. L. Bassi, J. Chastre, H. S. Jafri P091 - Risk factors and microbiological profile for nosocomial infections in trauma patients M. Ben Romdhane, Z. Douira, S. Kamoun, M. Bousselmi, A. Ben Souissi, Y. Boussarsar, A. Riahi, M.S. Mebazaa P092 - Correlation between percentages of ventilated patients developed vap and use of antimicrobial agents in ICU patients. A. Vakalos, V. Avramidis P093 - A comparison of two ventilator associated pneumonia surveillance techniques T. H. Craven, G. Wojcik, K. Kefala, J. McCoubrey, J. Reilly, R. Paterson, D. Inverarity, I. Laurenson, T. S. Walsh P094 - Lung ultrasound before and after fiberbronchoscopy - modifications may improve ventilator-associated pneumonia diagnosis S. Mongodi, B. Bouhemad, A. Orlando, A. Stella, G. Via, G. Iotti, A. Braschi, F. Mojoli P095 - Comparing the accuracy of predictors of mortality in ventilator-associated pneumonia M. Haliloglu, B. Bilgili, U. Kasapoglu, I. Sayan, M. Süzer Aslan, A. Yalcın, I. Cinel P096 - Impact of pRBCs transfusion on percentage of ventilated patients developed VAP in ICU patients A. Vakalos, V. Avramidis P097 - The impact of a series of interventions on the rate of ventilator associated pneumonia in a large teaching hospital H. E. Ellis, K. Bauchmuller, D. Miller, A Temple P098 - The EVADE study: Prevention of Nosocomial Pneumonia (NP) caused by P aeruginosa with MEDI3902, a Novel Bispecific Monoclonal Antibody, against P aeruginosa virulence factors J. Chastre, B. François, A. Torres, C. E. Luyt, M. Sánchez, M. Singer, H. S. Jafri P099 - Short-term inhaled colistin adjunctive therapy for ventilator-associated pneumonia Y. Nassar, M. S. Ayad P100 - Effect of aerosolised colistin on weaning from mechanical ventilation A. Trifi, S. Abdellatif, F. Daly, R. Nasri, S. Ben Lakhal P101 - Septic shock is an independent risk factor for colistin-induced severe acute kidney injury: a retrospective cohort study B. Bilgili, M. Haliloglu, F. Gul, I. Cinel P102 - Nosocomial pneumonia - emphasis on inhaled tobramycin A. Kuzovlev, A. Shabanov, S. Polovnikov, V. Moroz P103 - In vitro evaluation of amikacin inhale and commercial nebulizers in a mechanical ventilator N. Kadrichu, T. Dang, K. Corkery, P. Challoner P104 - The effects of nebulized amikacin/fosfomycin and systemic meropenem on severe amikacin-resistant meropenem-susceptible P.aeruginosa pneumonia G. Li Bassi, E. Aguilera, C. Chiurazzi, C. Travierso, A. Motos, L. Fernandez, R. Amaro, T. Senussi, F. Idone, J. Bobi, M. Rigol, A. Torres P105 - Optimization of gentamicin peak concentrations in critically ill patients C. J. Hodiamont, N. P. Juffermans, J. M. Janssen, C. S. Bouman, R. A. Mathôt, M. D. De Jong, R. M. Van Hest P106 - Systematic review of cefepime induced neurotoxicity L. Payne, G. L. Fraser P107 - Unasyn® causes QT prolongation during treatment of intensive care patients B. Tudor, M. Lahner, G. Roth, C. Krenn P108 - Comparative study between teicoplanin and vancomycin in methicillin-resistant staphylococcus aureus (mrsa) infectious of toxicological intensive care unit (ticu) patients – Tehran, Iran H. Talaie P109 - Phage therapy against antimicrobial resistance, design of the first clinical study phagoburn P. Jault, J. Gabard, T. Leclerc, S. Jennes, Y. Que, A. Rousseau, F. Ravat P110 - Antibiotic dosing errors in critically ill patients with severe sepsis or septic shock H. Al-Dorzi, A. Eissa, S. Al-Harbi, T. Aldabbagh, R. Khan, Y. Arabi P111 - Does empiric antifungal therapy improve survival in septic critically ill patients? (immunocompromised excluded) A. Trifi, S. Abdellatif, F. Daly, R. Nasri, S. Ben Lakhal P112 - Neurocysticercosis-Qatar experience F. Paramba, N. Purayil, V. Naushad, O. Mohammad, V. Negi, P. Chandra P113 - Early indicators in acute haemorrhagic shock A. Kleinsasser P114 - Filtering of red blood cells reduces the inflammatory response of pulmonary cells in an in vitro model of mechanical ventilation M. R. Witrz, J. F. Buchner-Doeven, A. M. Tuip-de Boer, J. C. Goslings, N. P. Juffermans P115 - Microparticles from red blood cell transfusion induce a pro-coagulant and pro-inflammatory endothelial cell response M. Van Hezel, M. Straat, A Boing, R Van Bruggen, N Juffermans P116 - The contribution of cytokines on thrombosis development during hospitalization in ICU D. Markopoulou, K. Venetsanou, V. Kaldis, D. Koutete, D. Chroni, I. Alamanos P117 - Prophylactic enoxaparin dosing and adjustment through anti-xa monitoring in an inpatient burn unit L. Koch, J. Jancik, H. Rhodes, E. Walter P118 - Determination of optimal cut-off values of haemoglobin, platelet count and fibrinogen at 24 hours after injury associated with mortality in trauma patients K. Maekawa, M. Hayakawa, S. Kushimoto, A. Shiraishi, H. Kato, J. Sasaki, H. Ogura, T. Matauoka, T. Uejima, N. Morimura, H. Ishikura, A. Hagiwara, M. Takeda P119 - Trauma-induced coagulopathy - prothrombin complex concentrate vs fresh frozen plasma O. Tarabrin, S. Shcherbakow, D. Gavrychenko, G. Mazurenko, V. Ivanova, O. Chystikov P120 - First study to prove the superiority of prothrombin complex concentrates on mortality rate over fresh frozen plasma in patients with acute bleeding C. Plourde, J. Lessard, J. Chauny, R. Daoust P121 - Prothrombin complex concentrate vs fresh frozen plasma in obstetric massive bleeding S. Shcherbakow, O. Tarabrin, D. Gavrychenko, G. Mazurenko, O. Chystikov P122 - Impact of FFP transfusion on VAP in ICU patients A. Vakalos, V. Avramidis P123 - Preoperative platelet function test and the thrombin generation assay are predictive for blood loss after cardiac surgery L. Kropman, L. In het Panhuis, J. Konings, D. Huskens, E. Schurgers, M. Roest, B. De Laat, M. Lance P124 - Rotational thromboelastometry versus standard coagulation tests before surgical interventions M. Durila, P. Lukas, M. Astraverkhava, J. Jonas P125 - Correction of impaired clot quality and stability by fibrinogen and activated prothrombin complex concentrate in a model of severe thrombocytopenia I. Budnik, B. Shenkman P126 - Assessment of point-of-care prothrombin time analyzer as a monitor after cardiopulmonary bypass H. Hayami, Y. Koide, T. Goto P127 - Disseminated intravascular coagulation (dic) is underdiagnosed in critically ill patients: do we need d-dimer measurements? R. Iqbal, Y. Alhamdi, N. Venugopal, S. Abrams, C. Downey, C. H. Toh, I. D. Welters P128 - Validity of the age-adjusted d-dimer cutoff in patients with COPD B. Bombay, J. M. Chauny, R. D. Daoust, J. L. Lessard, M. M. Marquis, J. P. Paquet P129 - A scoping review of strategies for prevention and management of bleeding following paediatric cardiopulmonary bypass surgery K. Siemens, D. Sangaran, B. J. Hunt, A. Durward, A. Nyman, I. A. Murdoch, S. M. Tibby P130 - Nadir hemoglobulin during cardiopulmonary bypass: impact on postoperative morbidity and mortality F. Ampatzidou, D. Moisidou, E. Dalampini, M. Nastou, E. Vasilarou, V. Kalaizi, H. Chatzikostenoglou, G. Drossos P131 - Red blood cell transfusion do not influence the prognostic value of RDW in critically ill patients S. Spadaro, A. Fogagnolo, T. Fiore, A. Schiavi, V. Fontana, F. Taccone, C. Volta P132 - Reasons for admission in the paediatric intensive care unit and the need for blood and blood products transfusions E. Chochliourou, E. Volakli, A. Violaki, E. Samkinidou, G. Evlavis, V. Panagiotidou, M. Sdougka P133 - The implementation of a massive haemorrhage protocol (mhp) for the management of major trauma: a ten year, single-centre study R. Mothukuri, C. Battle, K. Guy, G. Mills, P. Evans P134 - An integrated major haemorrhage protocol for pre-hospital and retrieval medical teams J. Wijesuriya, S. Keogh P135 - The impact of transfusion thresholds on mortality and cardiovascular events in patients with cardiovascular disease (non-cardiac surgery): a systematic review and meta-analysis A. Docherty, R. O’Donnell, S. Brunskill, M. Trivella, C. Doree, L. Holst, M. Parker, M. Gregersen, J. Almeida, T. Walsh, S. Stanworth P136 - The relationship between poor pre-operative immune status and outcome from cardiac surgery is specific to the peri-operative antigenic threat S. Moravcova, J. Mansell, A. Rogers, R. A. Smith, C. Hamilton-Davies P137 - Impact of simple clinical practice guidelines for reducing post-operative atrial fibrillation after cardiac surgery. A. Omar, M. Allam, O. Bilala, A. Kindawi, H. Ewila P138 - Dexamethasone administration during cardiopulmonary bypass has no beneficial effects on elective postoperative cardiac surgery patients F. Ampatzidou, D. Moisidou, M. Nastou, E. Dalampini, A. Malamas, E. Vasilarou, G. Drossos P139 - Intra-aortic balloon counterpulsation in patients undergoing cardiac surgery (IABCS): preliminary results G. Ferreira, J. Caldas, J. Fukushima, E. A. Osawa, E. Arita, L. Camara, S. Zeferino, J. Jardim, F. Gaioto, L. Dallan, F. B. Jatene, R. Kalil Filho, .F Galas, L. A. Hajjar P140 - Effects of low-dose atrial natriuretic peptide infusion on cardiac surgery-associated acute kidney injury C. Mitaka, T. Ohnuma, T. Murayama, F. Kunimoto, M. Nagashima, T. Takei, M. Tomita P141 - Acute kidney injury influence on high sensitive troponin measurements after cardiac surgery A. Omar, K. Mahmoud, S. Hanoura, S. Sudarsanan, P. Sivadasan, H. Othamn, Y. Shouman, R. Singh, A. Al Khulaifi P142 - Complex evaluation of endothelial dysfunction markers for prognosis of outcomes in patients undergoing cardiac surgery I. Mandel, S. Mikheev, I. Suhodolo, V. Kiselev, Y. Svirko, Y. Podoksenov P143 - New-onset atrial fibrillation in intensive care: incidence, management and outcome S. A. Jenkins, R. Griffin P144 - One single spot measurement of the sublingual microcirculation during acute pulmonary hypertension in a pig model of shock M. S. Tovar Doncel, A. Lima, C. Aldecoa, C. Ince P145 - Assessment of levosimendan as a therapeutic option to recruit the microcirculation in cardiogenic shock – initial experience in cardiac ICU A. Taha, A. Shafie, M. Mostafa, N. Syed, H. Hon P146 - Terlipressin vs. norepinephrine in the Potential Multiorgan Donor(PMD) F. Righetti, E. Colombaroli, G. Castellano P147 - Echocardiography in the potential heart donor exposed to substitution hormonotherapy F. Righetti, E. Colombaroli P148 - Machine learning can reduce rate of monitor alarms M. Hravnak, L. C. Chen, A. D. Dubrawski, G. C. Clermont, M. R. Pinsky P149 - Peripherally inserted central catheters placed in the ICU S. Gonzalez, D. Macias, J. Acosta, P. Jimenez, A. Loza, A. Lesmes, F. Lucena, C. Leon P150 - Recordings of abnormal central venous pressure waveform morphology during an episode of pulmonary hypertension in a porcine shock model M. S. Tovar Doncel, C. Ince, C. Aldecoa, A. Lima P151 - Ultrasound guided central venous access technique among French intensivists M. Bastide, J. Richecoeur, E. Frenoy, C. Lemaire, B. Sauneuf, F. Tamion, S. Nseir, D. Du Cheyron, H. Dupont, J. Maizel P152 - Predictive ability of the Pv-aCO2 gap in patients with shock M. Shaban, R. Kolko, N. Salahuddin, M. Sharshir, M. AbuRageila, A. AlHussain P153 - Comparison of echocardiography and pulmonary artery catheter measurements of hemodynamic parameters in critical ill patients P. Mercado, J. Maizel, L. Kontar, D. Titeca, F. Brazier, A. Riviere, M. Joris, T. Soupison, B. De Cagny, M. Slama P154 - The volume clamp method for noninvasive cardiac output measurement in postoperative cardiothoracic surgery patients: a comparison with intermittent pulmonary artery thermodilution J. Wagner, A. Körner, M. Kubik, S. Kluge, D. Reuter, B. Saugel P155 - Hemodynamic monitoring in patients with septic shock (SS) – CPCCO (continuous pulse contour cardiac output) vs. TEE (transesophageal echocardiography) E. Colombaroli, F. Righetti, G. Castellano P156 - Cardiac output measurement with transthoracic echocardiography in critically ill patients: a pragmatic clinical study T. Tran, D. De Bels, A. Cudia, M. Strachinaru, P. Ghottignies, J. Devriendt, C. Pierrakos P157 - Left ventricular outflow tract velocity time integral correlates with stroke volume index in mechanically ventilated patients Ó. Martínez González, R. Blancas, J. Luján, D. Ballesteros, C. Martínez Díaz, A. Núñez, C. Martín Parra, B. López Matamala, M. Alonso Fernández, M. Chana P158 - Transpulmonary thermodilution (TPTD) derived from femoral vs. jugular central venous catheter: validation of a previously published correction formula and a proprietary correction formula for global end-diastolic volume index (GEDVI) W. Huber, M. Eckmann, F. Elkmann, A. Gruber, I. Klein, R. M. Schmid, T. Lahmer P160 - Dynamic arterial elastance calculated with lidcoplus monitor does not predict changes in arterial pressure after a fluid challenge in postsurgical patients D. Bastoni, H. Aya, L. Toscani, L. Pigozzi, A. Rhodes, M. Cecconi P159 - Venous return driving pressure and resistance in acute blood volume changes P. W. Moller, S. Sondergaard, S. M. Jakob, J. Takala, D. Berger P160 - Dynamic arterial elastance calculated with lidcoplus monitor does not predict changes in arterial pressure after a fluid challenge in postsurgical patients D. Bastoni, H. Aya, L. Toscani, L. Pigozzi, A. Rhodes, M. Cecconi P161 - Analysis of duration of post-operative goal-directed therapy protocol C. Ostrowska, H. Aya, A. Abbas, J. Mellinghoff, C. Ryan, D. Dawson, A. Rhodes, M. Cecconi P162 - Hemodynamic optimization – back to square one? M. Cronhjort, O. Wall, E. Nyberg, R. Zeng, C. Svensen, J. Mårtensson, E. Joelsson-Alm P163 - Effectiveness of fluid thoracic content measurement by bioimpedance guiding intravascular volume optimization in patients with septic shock M. Aguilar Arzapalo, L. Barradas, V. Lopez, M. Cetina P164 - A systematic review on the role of internal jugular vein ultrasound measurements in assessment of volume status in critical shock patients N. Parenti, C. Palazzi, L. A. Amidei, F. B. Borrelli, S. C. Campanale, F. T. Tagliazucchi, G. S. Sedoni, D. L. Lucchesi, E. C. Carella, A. L Luciani P165 - Importance of recognizing dehydration in medical Intensive Care Unit M. Mackovic, N. Maric, M. Bakula P166 - Effect of volume for a fluid challenge in septic patients H. Aya, A. Rhodes, R. M. Grounds, N. Fletcher, M. Cecconi P167 - Fluid bolus practices in a large Australian intensive care unit B. Avard, P. Zhang P168 - Liberal late fluid management is associated with longer ventilation duration and worst outcome in severe trauma patients: a retrospective cohort of 294 patients M. Mezidi, J. Charbit, M. Ould-Chikh, P. Deras, C. Maury, O. Martinez, X. Capdevila P169 - Association of fluids and outcomes in emergency department patients hospitalized with community-acquired pneumonia P. Hou, W. Z. Linde-Zwirble, I. D. Douglas, N. S. Shapiro P170 - Association of positive fluid balance with poor outcome in medicosurgical ICU patients A. Ben Souissi, I. Mezghani, Y. Ben Aicha, S. Kamoun, B. Laribi, B. Jeribi, A. Riahi, M. S. Mebazaa P171 - Impact of fluid balance to organ dysfunction in critically ill patients C. Pereira, R. Marinho, R. Antunes, A. Marinho P172 - Volume bolus in ICU patients: do we need to balance our crystalloids? M. Crivits, M. Raes, J. Decruyenaere, E. Hoste P173 - The use of 6 % HES solution do not reduce total fluid requirement in the therapy of patients with burn shock V. Bagin, V. Rudnov, A. Savitsky, M. Astafyeva, I. Korobko, V. Vein P174 - Electron microscopic assessment of acute kidney injury in septic sheep resuscitated with crystalloids or different colloids T. Kampmeier , P. Arnemann, M. Hessler, A. Wald, K. Bockbreder, A. Morelli, H. Van Aken, S. Rehberg, C. Ertmer P175 - Alterations of conjunctival microcirculation in a sheep model of haemorrhagic shock and resuscitation with 0.9 % saline or balanced tetrastarch P. Arnemann, M. Hessler, T. Kampmeier, S. Rehberg, H. Van Aken, C. Ince, C. Ertmer P176 - A single centre nested pilot study investigating the effect of using 0.9 % saline or Plasma-Lyte 148 ® as crystalloid fluid therapy on gastrointestinal feeding intolerance in mechanically ventilated patients receiving nasogastric enteral nutrition S. Reddy, M. Bailey, R. Beasley, R. Bellomo, D. Mackle, A. Psirides, P. Young P177 - A single centre nested pilot study investigating the effect on post-operative bleeding of using 0.9 % saline or Plasma-Lyte® 148 as crystalloid fluid therapy in adults in ICU after heart surgery S. Reddy, M. Bailey, R. Beasley, R. Bellomo, D. Mackle, P. Young P178 - Extreme hypernatremia and sepsis in a patient with Huntington’s dementia: a conundrum in fluid management H. Venkatesh, S. Ramachandran, A. Basu, H. Nair P179 - Diagnosis and management of severe hypernatraemia in the critical care setting S. Egan, J. Bates P180 - Correlation between arterial blood gas and electrolyte disturbances during hospitalization and outcome in critically ill patients S. Oliveira, N. R. Rangel Neto, F. Q. Reis P181 - Missing the “I” in MUDPILES – a rare cause of high anion gap metabolic acidosis (HAGMA) C. P. Lee, X. L. Lin, C. Choong , K. M. Eu, W. Y. Sim , K. S. Tee, J. Pau , J. Abisheganaden P182 - Plasma NGAL and urinary output: potential parameters for early initiation of renal replacement therapy K. Maas, H. De Geus P183 - Renal replacement therapy for critically ill patients: an intermittent continuity E. Lafuente, R. Marinho, J. Moura, R. Antunes, A. Marinho P184 - A survey of practices related to renal replacement therapy in critically ill patients in the north of England. T. E. Doris, D. Monkhouse, T. Shipley, S. Kardasz, I Gonzalez P185 - High initiation creatinine associated with lower 28-day mortality in critically ill patients necessitating continuous renal replacement therapy S. Stads, A. J. Groeneveld P186 - The impact of Karnofsky performance scale on outcomes in acute kidney injury patients receiving renal replacement therapy on the intensive care unit I. Elsayed, N. Ward, A. Tridente, A. Raithatha P187 - Severe hypophosphatemia during citrate-anticoagulated CRRT A. Steuber, C. Pelletier, S. Schroeder, E. Michael, T. Slowinski, D. Kindgen-Milles P188 - Citrate regional anticoagulation for post dilution continuous renal replacement therapy S. Ghabina P189 - Citrate 18 mmol/l improves anticoagulation during RRT with adsorbing filters F. Turani, A. Belli, S. Busatti, G. Barettin, F. Candidi, F. Gargano, R. Barchetta, M. Falco P190 - Calcium gluconate instead of calcium chloride in citrate-anticoagulated CVVHD O. Demirkiran, M. Kosuk, S. Bozbay P191 - Enhanced clearance of interleukin-6 with continuous veno-venous haemodialysis (CVVHD) using Ultraflux EMiC2 vs. Ultraflux AV1000S V. Weber, J. Hartmann, S. Harm, I. Linsberger, T. Eichhorn, G. Valicek, G. Miestinger, C. Hoermann P192 - Removal of bilirubin with a new adsorbent system: in vitro kinetics S. Faenza, D. Ricci, E. Mancini, C. Gemelli, A. Cuoghi, S. Magnani, M. Atti P193 - Case series of patients with severe sepsis and septic shock treated with a new extracorporeal sorbent T. Laddomada, A. Doronzio, B. Balicco P194 - In vitro adsorption of a broad spectrum of inflammatory mediators with CytoSorb® hemoadsorbent polymer beads M. C. Gruda, P. O’Sullivan, V. P. Dan, T. Guliashvili, A. Scheirer, T. D. Golobish, V. J. Capponi, P. P. Chan P195 - Observations in early vs. late use of cytosorb therapy in critically ill patients K. Kogelmann, M. Drüner, D. Jarczak P196 - Oxiris membrane decreases endotoxin during rrt in septic patients with basal EAA > 0,6 F. Turani, A. B. Belli, S. M. Martni, V. C. Cotticelli, F. Mounajergi, R. Barchetta P197 - An observational prospective study on the onset of augmented renal clearance: the first report S. Morimoto, H. Ishikura P198 - An ultrasound- guided algorithm for the management of oliguria in severe sepsis I. Hussain, N. Salahuddin, A. Nadeem, K. Ghorab, K. Maghrabi P199 - Ultrasound in acute kidney injury (aki). First findings of farius, an education-programme in structural ultrasonography S. K. Kloesel, C. Goldfuss, A. Stieglitz, A. S. Stieglitz, L. Krstevska, G. Albuszies P200 - Effectiveness of renal angina index score predicting acute kidney injury on critically ill patients M. Aguilar Arzapalo, L. Barradas, V. Lopez, A. Escalante, G. Jimmy, M. Cetina P201 - Time length below blood pressure thresholds and progression of acute kidney injury in critically ill patients with or without sepsis: a retrospective, exploratory cohort study J. Izawa, T. Iwami, S. Uchino, M. Takinami, T. Kitamura, T. Kawamura P202 - Anaemia does not affect renal recovery in acute kidney injury J. G. Powell-Tuck, S. Crichton, M. Raimundo, L. Camporota, D. Wyncoll, M. Ostermann P203 - Estimated glomerular filtration rate based on serum creatinine: actual practice in Dutch ICU’s A. Hana, H. R. De Geus P204 - Comparison of estimated glomerular filtration rate calculated by mdrd, ckd-epi-serum-creatinine and ckd-epi-cystatin-c in adult critically ill patients H. R. De Geus, A. Hana P205 - Early diagnosis of septic acute kidney injury in medical critical care patients with a urine cell cycle arrest marker: insulin like growth factor binding protein-7 (IGFBP-7) M. Aydogdu, N. Boyaci, S. Yuksel, G. Gursel, A. B. Cayci Sivri P206 - Urinary neutrophil gelatinase-associated lipocalin as early biomarker of severe acute kidney injury in intensive care J. Meza-Márquez, J. Nava-López, R. Carrillo-Esper P207 - Shrunken pore syndrome is associated with a sharp rise in mortality in patients undergoing elective coronary artery bypass grafting A. Dardashti, A. Grubb P208 - The biomarker nephrocheck™ can discriminate the septic shock patients with an akin 1 or 2 acute renal failure who will not progress toward the akin 3 level J. Maizel, M. Wetzstein, D. Titeca, L. Kontar, F. Brazier, B. De Cagny, A. Riviere, T. Soupison, M. Joris, M. 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Bhandari P221 - Setting optimal flow rate during high flow nasal cannula support: preliminary results T. Mauri, C. Turrini, T. Langer, P. Taccone, C. A. Volta, C. Marenghi, L. Gattinoni, A. Pesenti P222 - Dose to dose consistency across two different gas flow rates using cystic fibrosis and normal adult breathing profiles during nasal high flow oxygen therapy L. Sweeney, A . O’ Sullivan, P. Kelly, E. Mukeria, R. MacLoughlin P223 - Final results of an evaluation of airway medix closed suction system compared to a standard closed suction system M. Pfeffer, J. T. Thomas, G. B. Bregman, G. K. Karp, E. K. Kishinevsky, D. S. Stavi, N. A. Adi P224 - Different cuff materials and different leak tests - one size does not fit all T. Poropat, R. Knafelj P225 - Observational study on the value of the cuff-leak test and the onset of upper airway obstruction after extubation E. Llopart, M. Batlle, C. De Haro, J. Mesquida, A. Artigas P226 - A device for emergency transtracheal lung ventilation D. Pavlovic, L. Lewerentz, A. Spassov, R. Schneider P227 - Long-term outcome and health-related quality of life in patients discharged from the intensive care unit with a tracheostomy and with or without prolonged mechanical ventilation S. De Smet, S. De Raedt, E. Derom, P Depuydt, S. Oeyen, D. Benoit, J. Decruyenaere P228 - Ultrasound-guided percutaneous dilational tracheostomy versus bronchoscopy-guided percutaneous dilational tracheostomy in critically ill patients (trachus): a randomized clinical trial A. Gobatto, B. Bese, P. Tierno, L. Melro, P. Mendes, F. Cadamuro, M. Park, L. M. Malbouisson P229 - Is it safe to discharge patients with tracheostomy from the ICU to the ward? B. C. Civanto, J. L. Lopez, A. Robles, J. Figueira, S. Yus, A. Garcia P230 - The application of tracheostomy in children in ICU A. Oglinda, G. Ciobanu, C. Oglinda, L. Schirca, T. Sertinean, V. Lupu P231 - The impact of passive humidifiers on aerosol drug delivery during mechanical ventilation P. Kelly, A. O’Sullivan, L. Sweeney, R. MacLoughlin P232 - Evaluation of vibrating mesh and jet nebuliser performance at two different attachment setups in line with a humidifier nebuliser system A. O’Sullivan, P. Kelly, L. Sweeney, E. Mukeria, M. Wolny , R. MacLoughlin P233 - Psv-niv versus cpap in the treatment of acute cardiogenic pulmonary edema A. Pagano, F. Numis, G. Vison, L. Saldamarco, T. Russo, G. Porta, F. Paladino P234 - Noninvasive ventilation in patients with haematologic malignancy: a retrospective review C. Bell, J. Liu, J. Debacker, C. Lee, E. Tamberg, V. Campbell, S. Mehta P235 - Use of non-invasive ventilation in infectious diseases besides classical indications A. Silva-Pinto, A. Sarmento, L. Santos P236 - The impact of fragility on noninvasive mechanical ventilation application and results in the ICU Ý. Kara, F. Yýldýrým, A. Zerman, Z. Güllü, N. Boyacý, B. Basarýk Aydogan, Ü. Gaygýsýz, K. Gönderen, G. Arýk, M. Turkoglu, M. Aydogdu, G. Aygencel, Z. Ülger, G. 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Gagliardi P247 - Dorsal diaphragmatic excursion tracks transpulmonary pressure in ventilated ARDS patients: a potential non-invasive indicator of lung recruitment? R. Cho, A. Adams , S. Lunos, S. Ambur, R. Shapiro, M. Prekker P248 - Pulse oximetry in the icu patient: is the perfusion index of any value? M. Thijssen, L. Janssen, N. Foudraine P249 - Ventilation is a better assessment of respiratory status than EtCO2 C. J. Voscopoulos, J. Freeman P250 - Evaluation of the relationship between non-invasive minute ventilation and end-tidal CO2 in patients undergoing general vs spinal anesthesia C. J. Voscopoulos, J. Freeman, E. George P251 - Respiratory volume monitoring provides early warning of respiratory depression and can be used to reduce false alarms in non-intubated patients C. J. Voscopoulos, D. Eversole, J. Freeman, E. George P252 - P/i index: a predictive edi-derived weaning index during nava S. Muttini, R. Bigi, G. Villani, N. 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Numis, C. S. Serra, A. P. Pagano, M. M. Masarone, L. R. Rinaldi, A. A. Amelia, M. F. Fascione, L. A. Adinolfi, E. R. Ruggiero P259 - Outcome of patients admitted to the intensive care with pulmonary fibrosis F. Asota, K. O’Rourke, S. Ranjan, P. Morgan P260 - Sedation and analgesia practice in extra-corporeal membrane oxygenation (ECMO)-treated patients with acute respiratory distress syndrome (ARDS): a retrospective study J. W. DeBacker, E. Tamberg, L. O’Neill, L. Munshi, L. Burry, E. Fan, S. Mehta P261 - Characteristics and outcomes of patients deemed not eligible when referred for veno-venous extracorporeal membrane oxygenation (vv-ECMO) S. Poo, K. Mahendran, J. Fowles, C. Gerrard, A. Vuylsteke P262 - The SAVE SMR for veno-arterial ECMO R. Loveridge, C. Chaddock, S. Patel, V. Kakar, C. Willars, T. Hurst, C. Park, T. Best, A. Vercueil, G. Auzinger P263 - A simplified score to predict early (48 h) mortality in patients being considered for VA-ECMO A. Borgman, A. G. Proudfoot, E. Grins, K. E. Emiley, J. Schuitema, S. J. Fitch, G. Marco, J. Sturgill, M. G. Dickinson, M. Strueber, A. Khaghani, P. Wilton, S. M. Jovinge P264 - Lung function six months post extra corporeal membrane oxygenation (ECMO) for severe acute respiratory failure in adult survivors C. Sampson, S. Harris-Fox P265 - Bicarbonate dialysis removes carbon dioxide in hypoventilated rodents. M. E. Cove, L. H. Vu, A. Sen, W. J. Federspiel, J. A. Kellum P266 - Procalcitonin as predictor of primary graft dysfunction and mortality in post-lung transplantation C. Mazo Torre, J. Riera, S. Ramirez, B. Borgatta, L. Lagunes, J. Rello P267 - New molecular biomarkers of acute respiratory distress syndrome in abdominal sepsis A. K. Kuzovlev, V. Moroz, A. Goloubev, S. Polovnikov, S. Nenchuk P268 - Tight junction’s proteins claudin -5 and regulation by tnf in experimental murine lung injury model of ali/ards V. Karavana, C. Glynos, A. Asimakos, K. Pappas, C. Vrettou, M. Magkou, E. Ischaki, G. Stathopoulos, S. Zakynthinos P269 - Cell counts in endobronchial aspirate to assess airway inflammation in ARDS patients: a pilot study S. Spadaro, I. Kozhevnikova, F. Dalla Corte, S. Grasso, P. Casolari, G. Caramori, C. Volta P270 - Epidemiological and clinical profile of patients with acute respiratory distress syndrome in the surgical intensive care unit surgical, hospital JRA, Antananarivo T. Andrianjafiarinoa, T. Randriamandrato, T. Rajaonera P271 - Effect of high PEEP after recruitment maneuver on right ventricular function in ARDS. Is it good for the lung and for the heart? S. El-Dash, ELV Costa, MR Tucci, F Leleu, L Kontar, B. De Cagny, F. Brazier, D. Titeca, G. Bacari-Risal, J. Maizel, M. Amato, M. Slama P272 - Effect of recruitment maneuver on left ventricular systolic strain P. Mercado, J. Maizel, L. Kontar, D. Titeca, F. Brazier, A. Riviere, M. Joris, T. Soupison, B. De Cagny, S. El Dash, M. Slama P273 - Inhaled nitric oxide – is switching supplier cost effective? Remmington, A. 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Varo Pérez P279 - Diarrhea is a risk factor for liver injury and may lead to intestinal failure associated liver disease in critical illness N. Lefel, F. Schaap, D. Bergmans, S. Olde Damink, M. Van de Poll P280 - Bowel care on the intensive care unit: constipation guideline compliance and complications K. Tizard, C. Lister, L. Poole P281 - Malnutrition assessed by phase angle determines outcomes in low risk cardiac surgery patients D. Ringaitiene, D. Gineityte, V. Vicka, I. Norkiene, J. Sipylaite P282 - Preoperative fasting times in an irish hospital A. O’Loughlin, V. Maraj, J. Dowling P283 - Costs and final outcome of early x delayed feeding in a private Brazil ICU M. B. Velasco, D. M. Dalcomune, E. B. Dias, S. L. Fernandes P284 - Can ventilator derived energy expenditure measurements replace indirect calorimetry? T. Oshima, S. Graf, C. Heidegger, L. Genton, V. Karsegard, Y. Dupertuis, C. Pichard P285 - Revisiting the refeeding syndrome: results of a systematic review N. Friedli, Z. Stanga, B. Mueller, P. Schuetz P286 - Compliance with the new protocol for parenteral nutrition in our ICU L. Vandersteen, B. Stessel, S. Evers, A. Van Assche, L. Jamaer, J. Dubois P287 - Nutrition may be another treatment in the intensive care unit where less is more? R. Marinho, H. Castro, J. Moura, J. Valente, P. Martins, P. Casteloes, C. Magalhaes, S. Cabral, M. Santos, B. Oliveira, A. Salgueiro, A. Marinho P288 - Should we provide more protein to critically ill patients? R. Marinho, M. Santos, E. Lafuente, H. Castro, S. Cabral, J. Moura, P. Martins, B. Oliveira, A. Salgueiro, S. Duarte, S. Castro, M. Melo, P. Casteloes, A. Marinho P289 Protein provision in an adult intensive care unit S. Gray P290 - Prevalence and clinical outcomes of vitamin d deficiency in the medical critically ill patients in Songklanagarind hospital K. Maipang, R. Bhurayanontachai P291 - Vitamin d deficiency strongly predicts adverse medical outcome across different medical inpatient populations: results from a prospective study L. G. Grädel, P. Schütz P292 - Omega-3 fatty acids in patients undergoing cardiac surgery: a systematic review and meta-analysis P. Langlois, W. Manzanares P293 - Can 5-hydroxytriptophan prevent post-traumatic stress disorder in critically ill patients? R. Tincu, C. Cobilinschi, D. Tomescu, Z. Ghiorghiu, R. Macovei P294 - Parenteral selenium in the critically ill: an updated systematic review and meta-analysis W. Manzanares, P. Langlois, M. Lemieux, G. Elke, F. Bloos, K. Reinhart, D. Heyland P295 - Probiotics in the critically ill: an updated systematic review and meta-analysis P. Langlois, M. Lemieux, I. Aramendi, D. Heyland, W. Manzanares P296 - Diabetes with hyperglycemic crisis episodes may be associated with higher risk of pancreatic cancer: a population-based cohort study Y. 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Bertellini P318 Correlation between electroencephalographic findings and serum neuron specific enolase with outcome of post cardiac arrest patients A. Taha, T. Abdullah, S. Abdel Monem P319 Introduction of a targeted temperature management strategy following cardiac arrest in a district general hospital intensive care unit. S. Alcorn, S. McNeill, S. Russell P320 The evolution of cerebral oxygen saturation in post-cardiac arrest patients treated with therapeutic hypothermia W. Eertmans, C. Genbrugge, I. Meex, J. Dens, F. Jans, C. De Deyne P321 Prognostic factors and neurological outcomes of therapeutic hypothermia in comatose survivors from cardiac arrest: 8-year single center experience J. Cholkraisuwat, N. Kongpolprom P322 Adherence to targeted temperature management after out of hospital cardiac arrest B. Avard, R. Burns P323 Implementation of a therapeutic hypothermia protocol for comatose survivors of out-of-hospital cardiac arrest. A. Patarchi, T. 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Perkins P335 Timing of endovascular and surgical treatment for aneurysmal subarachnoid haemorrhage: early but not so fast. J. Rubio, J. A. Rubio, R. Sierra P336 Red blood cell transfusion in aneurysmal subarachnoid hemorrhage – the Sahara cohort study S. English, M. Chasse, A. Turgeon, F. Lauzier, D. Griesdale, A. Garland, D. Fergusson, R. Zarychanski, A. Tinmouth, C. Van Walraven, K. Montroy, J. Ziegler, R. Dupont Chouinard, R. Carignan, A. Dhaliwal, C. Lum, J. Sinclair, G. Pagliarello, L. McIntyre P337 - Aneurysmal subarachnoid hemorrhage and anemia: a canadian multi-centre retrospective cohort study S. English, M. Chasse, A. Turgeon, F. Lauzier, D. Griesdale, A. Garland, D. Fergusson, R. Zarychanski, A. Tinmouth, C. Van Walraven, K. Montroy, J. Ziegler, R. Dupont Chouinard, R. Carignan, A. Dhaliwal, C. Lum, J. Sinclair, G. Pagliarello, L. McIntyre P338 - Does the neutrophil-to-lymphocyte (NLR) ratio predict symptomatic vasospasm or delayed cerebral ischemia (DCI) after aneurysmal subarachnoid haemorrhage (SAH)? T. Groza, N. Moreau, D. Castanares-Zapatero, P. Hantson P339 - ICU-acquired infections in aneurysmal subarachnoid hemorrhage patients: impact on ICU and hospital length of stay M. Carbonara , F. Ortolano, T. Zoerle, S. Magnoni, S. Pifferi, V. Conte, N. Stocchetti P340 - Cerebral metabolic effects of normobaric hyperoxia during the acute phase of aneurysmal subarachnoid hemorrhage L. Carteron, T. Suys, C. Patet, H. Quintard, M. Oddo P341 - Postoperative care for elective craniotomy: where is best done? J. A. Rubio, J. Rubio, R. Sierra P342 - 5-year follow-up of patients after transplantation of organs from donors from neurocritical care V. Spatenkova, E. Pokorna, P. Suchomel P343 - Evaluation of levetiracetam pharmacokinetics after severe traumatic brain injury in neurocritical care patients at a level one trauma center N. Ebert, J. Jancik, H. Rhodes P344 - Model based time series cluster analysis to determine unique patient states in traumatic brain injury T. Bylinski, C. Hawthorne, M. Shaw, I. Piper, J. Kinsella P345 - Brain compartment monitoring capabilities from ICP to BI (bioimpedance) during HS (hypertonic saline) administration. State of art simulation outcome depending on brain swelling type A. K. Kink , I. R. Rätsep P346 - Transfusion of red blood cells in patients with traumatic brain injury admitted to Canadian trauma health centers: a multicenter cohort study A. Boutin, L. Moore, M. Chasse, R. Zarychanski, F. Lauzier, S. English, L. McIntyre, J. Lacroix, D. Griesdale, P. Lessard-Bonaventure, A. F. Turgeon P347 - Hemoglobin thresholds and red blood cell transfusions in adult patients with moderate or severe traumatic brain injury: a retrospective cohort study A. Boutin, L. Moore, R. Green, P. Lessard-Bonaventure, M. Erdogan, M. Butler, F. Lauzier, M. Chasse, S. English, L. McIntyre, R. Zarychanski, J. Lacroix, D. Griesdale, P. Desjardins, D. A. Fergusson, A. F. Turgeon P348 - Characteristics of patients with gunshot wounds to the head - an observational Brazilian study B. Goncalves, B. Vidal, C. Valdez, A. C. Rodrigues, L. Miguez, G. Moralez P349 - Base excess as predictor for ICU admission and the injury severity in blunt trauma patients T. Hong P350 - Enhancement of usual emergency department care with proadrenomedullin to improve outcome prediction - Results from the multi-national, prospective, observational TRIAGE study A. Kutz, P. Hausfater, D. Amin, T. Struja, S. Haubitz, A. Huber, B. Mueller, P. Schuetz P351 - Developing an innovative emergency medicine point-of-care simulation programme T. Brown, J. Collinson, C. Pritchett, T. Slade P352 - The InSim program: an in situ simulation program for junior trainees in intensive care M. Le Guen, S. Hellings, R. Ramsaran P353 - Impact of excessive and inappropriate troponin testing in the emergency setting how good are we A. Alsheikhly P354 - The development of time tracking monitor at emergency department T. Abe P355 - Role of focussed echocardiography in emergency assessment of syncope L. Kanapeckaite, M. Abu-Habsa, R. Bahl P356 - Insertion of an open-ended 14-gauge catheter through the chest wall causes a significant pneumothorax in a self-ventilating swine model M. Q Russell, K. J. Real, M. Abu-Habsa , R. M. Lyon, N. P. Oveland P357 - Ez-io® intraosseous access teaching in the workplace using a mobile ‘tea trolley’ training method J. Penketh, M. Mcdonald, F. Kelly P358 - Black widow envenomation in Saudi Arabia: a prospective observational case series M. Alfafi, S. Alsolamy, W. Almutairi, B. Alotaibi P359 - Mechanical ventilation in patients with overdose not yet intubated on icu admission A. E. Van den Berg, Y. Schriel, L. Dawson, I. A. Meynaar P360 - Central nervous system depressants poisoning and ventilator associated pneumonia: an underrated risk factor in toxicological intensive care unit H. Talaie P361 - Acute barium intoxication treated with hemodiafiltration D. Silva, S. Fernandes, J. Gouveia, J. Santos Silva P362 - Major trauma presenting to the emergency department. the spectrum of cycling injuries in Ireland J. Foley, A. Kaskovagheorgescu, D. Evoy, J. Cronin, J. Ryan P363 - Burns from French military operations: a 14-year retrospective observational analysis. M. Huck, C. Hoffmann, J. Renner, P. Laitselart, N. Donat, A. Cirodde, J. V. Schaal, Y. Masson, A. Nau, T. Leclerc P364 - A comparison of mortality scores in burns patients on the intensive care unit. O. Howarth, K. Davenport, P. Jeanrenaud, S. Raftery P365 - Clasification of pain and its treatment and an intensive care rehabiliation clinic P. MacTavish, H. Devine, J. McPeake, M. Daniel, J. Kinsella, T. Quasim P366 - Pain management adequacy in critical care areas ,the process and the barriers perceived by critical care nurses S. Alrabiee, A. Alrashid , S. Alsolamy P367 - Pain assessment in critically ill adult patients: validation of the Turkish version of the critical-care pain observation tool O. Gundogan, C. Bor, E. Akýn Korhan, K. Demirag , M. Uyar P368 - An audit of pain and sedation assessments in the intensive care unit: recommendations for clinical practice F. Frame, C. Ashton, L. Bergstrom Niska P369 - Impact of pharmaceutical care on treatment of pain and agitation in medical intensive care unit P. Dilokpattanamongkol, T. Suansanae, C. Suthisisang, S. Morakul, C. Karnjanarachata, V. Tangsujaritvijit P370 - Agitation in trauma ICU, prevention and outcome S. Mahmood, H. Al Thani, A. Almenyar P371 Correlation between percentages of ventilated patients developed vap and use of sedative agents in icu patients. A. Vakalos , V. Avramidis P372 - Improving recording of sedation events in the Emergency Department: The implementation of the SIVA International Taskforce adverse event reporting tool for procedural sedation R. Sharvill, J. Penketh P373 - Impact of sedative drug use on the length of mechanical ventilation S. E. Morton, Y. S. Chiew, C. Pretty, J. G. Chase, G. M. Shaw P374 - Co-administration of nitric oxide and sevoflurane using anaconda R. Knafelj, P. Kordis P375 - A retrospective study of the use of Dexmedetomidine in an oncological critical care setting S. Patel, V. Grover P376 - Dexmedetomidine and posttraumatic stress disorder incidence in alcohol withdrawal icu patients I. Kuchyn, K. Bielka P377 - Hemodynamic effects of dexmedetomidine in a porcine model of septic shock Z. Aidoni, V. Grosomanidis, K. Kotzampassi, G. Stavrou, B. Fyntanidou, S. Patsatzakis, C. Skourtis P378 - Ketamine for analgosedation in severe hypoxic respiratory failure S. D. Lee, K. Williams, I. D. Weltes P379 - Madness from the moon? lunar cycle and the incidence of delirium on the intensive care unit S. Berhane, C. Arrowsmith, C. Peters, S. Robert P380 - Impaired dynamic cerebral autoregulation after coronary artery bypass grafting and association with postoperative delirium J. Caldas, R. B. Panerai, T. G. Robinson, L. Camara, G. Ferreira, E. Borg-Seng-Shu, M. De Lima Oliveira, N. C. Mian, L. Santos, R. Nogueira, S. P. Zeferino, M. Jacobsen Teixeira, F. Galas, L. A. Hajjar P381 - Risk factors predicting prolonged intensive care unit length of stay after major elective surgery. P. Killeen, M. McPhail, W. Bernal, J. Maggs, J. Wendon, T. Hughes P382 - Systemic inflammatory response syndrome criteria and hospital mortality prediction in a brazilian cohort of critically ill patients L. U. Taniguchi, E. M. Siqueira, J. M. Vieira Jr, L. C. Azevedo P383 - Evaluating the efficacy of a risk predictor panel in identifying patients at elevated risk of morbidity following emergency admission A. N. Ahmad, M. Abu-Habsa, R. Bahl, E. Helme, S. Hadfield, R. Loveridge P384 - A retrospective comparison of outcomes for elective surgical patients admitted post-operatively to the critical care unit or general ward J. Shak, C. Senver, R. Howard-Griffin P385 - Effect of obesity on mortality in surgical critically ill patients. P. Wacharasint, P. Fuengfoo, N. Sukcharoen, R. Rangsin P386 - The national early warning score (news) reliably improves adverse clinical outcome prediction in community-acquired pneumonia - results from a 6 year follow-up D. Sbiti-Rohr, P. Schuetz P387 - Clinical usefulness of the charlson¡¯s weighted index of comorbidities _as prognostic factor in patients with prolonged acute mechanical ventilation H. Na, S. Song, S. Lee, E. Jeong, K. Lee P388 - Comparison of mortality prediction scoring systems in patients with cirrhosis admitted to general intensive care unit M. Cooper, K. Milinis, G. Williams, E. McCarron, S. Simants, I. Patanwala, I. D. Welters P389 - Impact of admission source and time of admission on outcome of pediatric intensive care patients: retrospective 15 years study E. Zoumpelouli, EA Volakli, V. Chrysohoidou, S. Georgiou, K. Charisopoulou, E. Kotzapanagiotou, V. Panagiotidou, K. Manavidou, Z. Stathi, M. Sdougka P390 - Heart rate variability and outcomes prediction in critical illness N. Salahuddin, B. AlGhamdi, Q. Marashly, K. Zaza, M. Sharshir, M. Khurshid, Z. Ali, M. Malgapo, M. Jamil, A. Shafquat, M. Shoukri, M. Hijazi P391 - The incidence and outcome of hyperlactatemia in the post anaesthesia care unit T. Abe, S. Uchino, M. Takinami P392 - Correlation between arterial blood gas disturbances and arterial lactate levels during hospitalization and outcome in critically septic patients N. R. Rangel Neto, S. Oliveira, F. Q. Reis, F. A. Rocha P393 - External validation of saps 3 and mpm iii scores in 48,816 patients from 72 brazilian icus G. Moralez, K. Ebecken, L. S. Rabello, M. F. Lima, R. Hatum, F. V. De Marco, A. Alves, J. E. Pinto, M. Godoy, P. E. Brasil, F. A. Bozza, J. I. Salluh, M. Soares P394 - The frailty penalty: pre-admission functional status confounds mortality prediction models in critically ill patients J. Krinsley, G. Kang P395 - ‘sooner rather than later”: how delayed discharge from critical care leads to increased out of hours discharges and subsequent increase in in-hospital mortality. J. Perry, H. Hines P396 - Identifying poor outcome patient groups in a resource-constrained critical care unit K. M. Wilkinson, C. Tordoff, B. Sloan, M. C. Bellamy P397 - Effects of icu weekend admission and discharge on mortality. E. Moreira, F. Verga, M. Barbato, G. Burghi P398 - Organizational factors, outcomes and resource use in 9,946 cancer patients admitted to 70 ICUs M Soares, U. V. Silva, L. C. Azevedo, A. P. Torelly, J. M. Kahn, D. C. Angus, M. F. Knibel, P. E. Brasil, F. A. Bozza, J. I. Salluh P399 - Evaluation of oncological critically ill patients, severity score and outcome compared to not oncological in a particular hospital cti. M. B. Velasco, D. M. Dalcomune P400 - Outcomes of patients admitted to a large uk critical care department with palliative oncological diagnoses R. Marshall, T. Gilpin, A. Tridente, A. Raithatha P401 - Predictors of mortality in febrile neutropenic patients with haematological malignancies admitted to an intensive care unit of a cancer center D. Mota, B. Loureiro, J. Dias, O. Afonso, F. Coelho, A. Martins, F. Faria P402 - Patients with hematologic malignancies requiring invasive mechanical ventilation: characteristics and predictors of mortality H. Al-Dorzi, H. Al Orainni , F. AlEid, H. Tlaygeh, A. Itani, A. Hejazi, Y. Arabi P403 - Patient-important outcomes in randomized controlled trials in critically ill patients: a systematic review S. Gaudry, J. Messika, J. D. Ricard, S. Guillo, B. Pasquet, E. Dubief, D. Dreyfuss, F. Tubach P404 - Alopecia in survivors of critical illness: a qualitative study C . Battle, K. James, P. Temblett P405 - The impact of mental health on icu admission L. Davies, C. Battle, C. Lynch P406 - Cognitive impairment 5 years after ICU discharge S. Pereira, S. Cavaco, J. Fernandes, I. Moreira, E. Almeida, F. Seabra Pereira, M. Malheiro, F. Cardoso, I. Aragão, T. Cardoso P407 - Apache ii versus apache iv for octagenerians in medical icu M. Fister, R. Knafelj P408 - Outcomes of octagenarians in an indian icu P. Muraray Govind, N. Brahmananda Reddy, R. Pratheema, E. D. Arul, J. Devachandran P409 - Mortality and outcomes in elderly patients 80 years of age or older admitted to the icu M. B. Velasco , D. M. Dalcomune P410 - Octagenerians in medical icu - adding days to life or life to days? R. Knafelj, M. Fister P411 - The very elderly admitted to intensive care unit: outcomes and economic evaluation N. Chin-Yee, G. D’Egidio, K. Thavorn, D. Heyland, K. Kyeremanteng P412 - The very elderly in intensive care: relationship between acuity of illness and long-term mortality A. G. Murchison, K. Swalwell, J. Mandeville, D. Stott P413 - Acquired weakness in an oncological intensive care unit I. Guerreiro P414 - Musculoskeletal problems in intensive care unit (ICU) patients post-discharge H. Devine, P. MacTavish, J. McPeake, T. Quasim, J. Kinsella, M. Daniel P415 - Premorbid obesity, but not nutrition, prevents critical illness-induced muscle wasting and weakness C. Goossens M. B. Marques, S. Derde, S. Vander Perre, T. Dufour, S. E. Thiessen, F. Güiza, T. Janssens, G. Hermans, I. Vanhorebeek, K. De Bock, G. Van den Berghe, L. Langouche P416 - Physical outcome measures for critical care patients following intensive care unit (icu) discharge H. Devine, P. MacTavish, T. Quasim, J. Kinsella, M. Daniel, J. McPeake P417 - Improving active mobilisation in a general intensive care unit B. Miles , S. Madden, H. Devine P418 - Mobilization in patients on vasoactive drugs use – a pilot study. M. Weiler, P. Marques, C. Rodrigues, M. Boeira, K. Brenner, C. Leães, A. Machado, R. Townsend, J. Andrade P419 - Pharmacy intervention at an intensive care rehabilitation clinic P. MacTavish, J. McPeake, H. Devine, J. Kinsella, M. Daniel, R. Kishore, C. Fenlon, T. Quasim P420 - Interactive gaming is feasible and potentially increases icu patients’ motivation to be engaged in rehabilitation programs T. Fiks, A. Ruijter, M. Te Raa, P. Spronk P421 - Simulation-based design of a robust stopping rule to ensure patient safety Y. S. Chiew, P. Docherty, J. Dickson, E. Moltchanova, C. Scarrot, C. Pretty, G. M. Shaw, J. G. Chase P422 - Are daily blood tests on the intensive care unit necessary? T. Hall, W. C. Ngu, J. M. Jack, P. Morgan P423 - Measuring urine output in ward patients: is it helpful? B. Avard, A. Pavli, X. Gee P424 - The incidence of pressure ulcers in an adult mixed intensive care unit in turkey C . Bor, E. Akin Korhan, K. Demirag, M. Uyar P425 - Intensivist/patient ratios in closed ICUs in Alexandria, Egypt; an overview M. Shirazy, A. Fayed P426 - Eicu (electronic intensive care unit): impact on ALOS (average length of stay) in a developing country like India S. Gupta, A. Kaushal, S. Dewan, A. Varma P427 - Predicting deterioration in general ward using early deterioration indicator E. Ghosh, L. Yang, L. Eshelman, B. Lord, E. Carlson P428 - High impact enhanced critical care outreach - the imobile service: making a difference E. Helme, R. Broderick, S. Hadfield, R. Loveridge P429 - Impact of bed availability and cognitive load on intensive care unit (ICU) bed allocation: a vignette-based trial J. Ramos, D. Forte P430 - Characteristics of critically ill patients admitted through the emergency department F. Yang, P. Hou P431 - Admission to critical care: the quantification of functional reserve J. Dudziak, J. Feeney, K. Wilkinson, K. Bauchmuller, K. Shuker, M. Faulds, A. Raithatha, D. Bryden, L. England, N. Bolton, A. Tridente P432 - Admission to critical care: the importance of frailty K. Bauchmuller, K Shuker, A Tridente, M Faulds, A Matheson, J. Gaynor, D Bryden, S South Yorkshire Hospitals Research Collaboration P433 - Development of an instrument to aid triage decisions for intensive care unit admission J. Ramos, B. Peroni, R. Daglius-Dias, L. Miranda, C. Cohen, C. Carvalho, I . Velasco, D. Forte P434 - Using selective serotonin re-uptake inhibitors and serotonin-norepinephrine re-uptake inhibitors in critical care: a systematic review of the evidence for benefit or harm J. M. Kelly, A. Neill, G. Rubenfeld, N. Masson, A. Min P435 - Measuring adaptive coping of hospitalized patients with a severe medical condition:the sickness insight in coping questionnaire (sicq) E. Boezeman, J. Hofhuis , A. Hovingh, R. De Vries, P. Spronk P436 - Results of a national survey regarding intensive care medicine training G. Cabral-Campello, I. Aragão, T. Cardoso P437 - Work engagement among healthcare professionals in the intensive care unit M. Van Mol, M. Nijkamp, E . Kompanje P438 - Empowering the intensive care practitioners. is it a burnout ameliorating intervention? P. Ostrowski, A. Omar P439 - Icu patients suffer from circadian rhythm desynchronisation K. Kiss , B. Köves, V. Csernus, Z. Molnár P440 - Noise reduction in the ICU: feasible ? Y. Hoydonckx, S. Vanwing, B. Stessel, A. Van Assche, L. Jamaer, J. Dubois P441 - Accidental removal of invasive devices in the critical patient into the bed-washing. does the presence of professional nurse modify his incidence? V. Medo, R. Galvez, J. P. Miranda P442 - Deprivation of liberty safeguards (dols): audit of compliance in a of a 16-bed specialist cancer critical care unit. C. Stone, T. Wigmore P443 - Use of a modified cristal score to predict futility of critical care in the elderly Y. Arunan, A. Wheeler, K. Bauchmuller, D. Bryden P444 - Improvement of Referral Rate to Palliative Care for Patients with Poor Prognosis in Neurosurgical Intensive Care Unit Y. Wong, C. Poi, C. Gu P445 - Factors associated with limitation of life supporting care (lsc) in a medico-surgical intermediate care unit, and outcome of patients with lsc limitation: a monocentric, six-month study. P. Molmy, N. Van Grunderbeeck, O. Nigeon, M. Lemyze, D. Thevenin, J. Mallat P446 - Palliative care consultation and intensive care unit admission request: a cohort study J. Ramos, M. Correa, R. T. Carvalho, D. Forte P447 - Nursing and medicine together in postsurgical intensive care unit: situations of prognostic conflict at the end of life. our critical care nurses suffer with our medical activism? A. Fernandez, C. McBride P448 - End of life who may decide E. Koonthalloor, C. Walsh P449 - Correctly diagnosing death A. Webber, M. Ashe, K. Smith, P. Jeanrenaud P450 - Skin procurement performed by intensive care physicians: yes, we can. A. Marudi , S. Baroni, F. Ragusa, E. Bertellini P451 - Death analysis in pediatric intensive care patients E. A. Volakli , E. Chochliourou, M. Dimitriadou, A. Violaki, P. Mantzafleri, E. Samkinidou, O. Vrani, A. Arbouti, T. Varsami, M. Sdougka P452 - The potential impact of euthanasia on organ donation: analysis of data from belgium J. A. Bollen, T. C. Van Smaalen, W. C. De Jongh, M. M. Ten Hoopen, D. Ysebaert, L. W. Van Heurn, W. N. Van Mook P453 - Communication within an intensive care setting K. Sim, A. Fuller P454 - Development and implementation of a longitudinal communication curriculum for critical care medicine fellows A. Roze des Ordons, P. Couillard, C. Doig P455 - Staff-family conflict in a multi-ethnic intensive care unit R. V. Van Keer, R. D. Deschepper, A. F. Francke, L. H. Huyghens, J. B. Bilsen P456 - Does the source of admission to critical care affect family satisfaction? B. Nyamaizi, C. Dalrymple, A. Molokhia, A. Dobru P457 - A simple alternative to the family satisfaction survey (fs-icu) E. Marrinan, A. Ankuli, A. Molokhia P458 - A study to explore the experiences of patient and family volunteers in a critical care environment: a phenomenological analysis J. McPeake, R. Struthers, R. Crawford , H. Devine , P. Mactavish , T. Quasim P459 - Prevalence and risk factors of anxiety and depression in relatives of burn patients. P. Morelli, M. Degiovanangelo, F. Lemos, V. MArtinez, F. Verga, J. Cabrera, G. Burghi P460 - Guidance of visiting children at an adult intensive care unit (icu) A. Rutten , S. Van Ieperen, S. De Geer, M. Van Vugt, E. Der Kinderen P461 - Visiting policies in Italian pediatric ICUs: an update A. Giannini, G Miccinesi, T Marchesi, E Prandi more...
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- 2016
37. Antioxidant effects of nanoencapsulated lipoic acid in tissues and on the immune condition in haemolymph of Pacific white shrimpLitopenaeus vannamei(Boone, 1931)
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da Silva Martins, Á.C., primary, Artigas Flores, J., additional, Porto, C., additional, Romano, L.A., additional, Wasielesky Junior, W., additional, Caldas, S.S., additional, Primel, E.G., additional, Külkamp-Guerreiro, I., additional, and Monserrat, J.M., additional more...
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- 2018
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38. small cell lung cancer: Retrospective review of an institution
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Silva, A., primary, Guerreiro, I., additional, Castro, C., additional, Brandao, M., additional, Rodrigues, A., additional, Oliveira, C., additional, Pousa, I., additional, Oliveira, J., additional, Azevedo, I., additional, and Soares, M., additional more...
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- 2017
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39. Prebiotics effect on growth performance, hepatic intermediary metabolism, gut microbiota and digestive enzymes of white sea bream (Diplodus sargus)
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Guerreiro, I., primary, Serra, C. R., additional, Pousão-Ferreira, P., additional, Oliva-Teles, A., additional, and Enes, P., additional
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- 2017
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40. Urachal carcinoma: A retrospective analysis of a reference cancer center
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Guerreiro, I., primary, Alves, S., additional, Lobo, J., additional, Rosinha, A., additional, Carneiro, F., additional, Faustino, C., additional, Sousa, N., additional, Henrique, R., additional, and Maurício, J., additional more...
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- 2016
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41. P-278 - Prognostic factors in metastatic colorectal cancer
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Silva, M., Guerreiro, I., Abreu, S., and Marques, D.
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- 2018
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42. Antioxidant effects of nanoencapsulated lipoic acid in tissues and on the immune condition in haemolymph of Pacific white shrimp Litopenaeus vannamei (Boone, 1931).
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da Silva Martins, Á.C., Artigas Flores, J., Porto, C., Romano, L. A., Wasielesky Junior, W., Caldas, S. S., Primel, E. G., Külkamp‐Guerreiro, I., and Monserrat, J. M.
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WHITELEG shrimp ,HEMOLYMPH ,LIPOIC acid ,NANOCAPSULES ,OXIDATIVE stress ,FISHES - Abstract
Abstract: The antioxidant and oxidative damage responses and immune parameters in shrimp, Litopenaeus vannamei, reared in clear water (CW) and in a biofloc system (BFT) were evaluated. The animals were given feed supplemented with either nanocapsules containing the antioxidant lipoic acid (NCLA) or empty nanocapsules (NC). Antioxidant and oxidative stress analyses were evaluated by measuring glutathione S‐transferase activity (GST), reduced glutathione (GSH) concentration and lipid peroxidation (TBARS) in the gills, hepatopancreas and muscle. The immune parameters were then determined by the differential hemocyte count in the haemolymph. The final weight of the shrimp reared in both CW and BFT and treated with NCLA increased (p < .05). The shrimps reared in BFT showed increased GST activity in the gills and hepatopancreas after NCLA treatment (p < .05). Higher GSH levels were observed in the hepatopancreas with NCLA supplementation in CW and BFT (p < .05). Decreased levels of TBARS were observed in the gills and muscles of shrimp supplemented with NCLA and maintained in CW (p < .05). A decrease in the percentage of hyaline hemocytes and an increase in granular hemocytes were observed in shrimp treated with NCLA in CW and BFT (p < .05). The antioxidant treatment induced positive responses in terms of the zootechnical, biochemical and immunological parameters. [ABSTRACT FROM AUTHOR] more...
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- 2018
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43. Prebiotics effect on growth performance, hepatic intermediary metabolism, gut microbiota and digestive enzymes of white sea bream (<italic>Diplodus sargus</italic>).
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Guerreiro, I., Serra, C. R., Pousão‐Ferreira, P., Oliva‐Teles, A., and Enes, P.
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FRUCTOOLIGOSACCHARIDES , *GUT microbiome , *NEMADACTYLUS macropterus , *FISH feeds , *FISH growth - Abstract
Abstract: This study aimed at evaluating the effects of short‐chain fructooligosaccharides (scFOS), xylooligosaccharides (XOS) and galactooligosaccharides (GOS) on growth performance, hepatic metabolism, gut microbiota and digestive enzymes activities of white sea bream juveniles. Four diets were formulated: a control diet with fish meal (FM) and plant feedstuffs (PF) (30FM:70PF) and three test diets similar to control but supplemented with 10 g of scFOS, XOS or GOS per kilo diet, which were fed to fish during 12 weeks. Prebiotics had no effect on growth, feed efficiency or gut microbiota. Plasmatic triglycerides were lower in fish fed XOS than FOS and GOS diets. Malic enzyme activity was lower in fish fed XOS than FOS diet. Fish fed XOS diet had lower fatty acid synthetase (FAS), a key lipogenic enzyme and higher alanine aminotransferase activities. Fifteen days after the start of the trial, an enhancement of total alkaline protease, trypsin and lipase activities was observed in fish fed prebiotics, but such effect disappeared at 12 weeks. In conclusion, scFOS, XOS or GOS seem to have limited applicability in white sea bream feed. [ABSTRACT FROM AUTHOR] more...
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- 2018
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44. Impact of dietary protein hydrolysates on skeleton quality and proteome in Diplodus sargus larvae
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Vareilles, Mahaut de, Richard, Nadège, Gavaia, Paulo J., Silva, T. S., Cordeiro, O., Guerreiro, I., Yúfera, Manuel, Batista, I., Pires, C., Pousão-Ferreira, P., and Rodrigues, P. M.
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Dietary protein ,Diplodus sagus larvae ,Metabolism ,fungi ,Skeleton quality - Abstract
In order to investigate the effects of dietary protein hydrolysates (PH) on larval growth performance, skeleton quality and proteome expression, triplicate groups of white seabream (Diplodus sargus) larvae were co-fed from first-feeding with live feed and three microencapsulated diets differing in the molecular weight of their PH fraction (Control – inclusion of CPSP-90; H – inclusion of a high amount in 0.5–30 kDa hydrolysates; L – inclusion of a high amount in, This study was partially supported by the projects SAARGO – POCI/MAR/6123/2004 and HYDRAA – PTDC/MAR/71685/2006, granted by Fundação para a Ciência e Tecnologia, Portugal. NR, M de V and TSS acknowledge financial support from Fundação para a Ciência e Tecnologia, Portugal, through grants SFRH/BDP/34888/2007, SFRH/BD/40698/2007 and SFRH/BD/41392/2007 respectively. more...
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- 2012
45. Wheat field high throughput phenotyping from concept to application
- Author
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COMAR, Alexis, De Solan, B., Burger, P., Baret, Frédéric, Daumard, F., Gouache, D., Guerreiro, I., Environnement Méditerranéen et Modélisation des Agro-Hydrosystèmes (EMMAH), Avignon Université (AU)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Laboratoire de Météorologie Dynamique (UMR 8539) (LMD), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-École polytechnique (X)-École des Ponts ParisTech (ENPC)-Centre National de la Recherche Scientifique (CNRS)-Département des Géosciences - ENS Paris, École normale supérieure - Paris (ENS Paris)-École normale supérieure - Paris (ENS Paris), Département des Géosciences - ENS Paris, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École des Ponts ParisTech (ENPC)-École polytechnique (X)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), and Déposants HAL-Avignon, bibliothèque Universitaire more...
- Subjects
[SDU] Sciences of the Universe [physics] ,[SDU]Sciences of the Universe [physics] ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2011
46. 1043 Resistance patterns of microbial isolates in cancer patients with infection in the emergency department and impact on outcome
- Author
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Silva, M.J., primary, Pereira, F., additional, Guerreiro, I., additional, Afonso, A., additional, Alves, S., additional, Dias, J.M.M., additional, Marques, D., additional, and Mergulhão, P., additional more...
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- 2015
- Full Text
- View/download PDF
47. IMPACTO DA QUIMISSORÇÃO NA ADSORÇÃO DE CO2 NO HÍBRIDO NaX/MEA
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de LIMA, A. E. O., additional, FONTENELE, T. V. G., additional, GUERREIRO, I. P. B., additional, and de LUCENA, S. M. P., additional
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- 2015
- Full Text
- View/download PDF
48. A mutation in FRIZZLED2 impairs Wnt signaling and causes autosomal dominant omodysplasia
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Saal, H. M., primary, Prows, C. A., additional, Guerreiro, I., additional, Donlin, M., additional, Knudson, L., additional, Sund, K. L., additional, Chang, C.-F., additional, Brugmann, S. A., additional, and Stottmann, R. W., additional more...
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- 2015
- Full Text
- View/download PDF
49. Effects of rearing temperature and dietary short-chain fructooligosaccharides supplementation on allochthonous gut microbiota, digestive enzymes activities and intestine health of turbot (Scophthalmus maximusL.) juveniles
- Author
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Guerreiro, I., primary, Enes, P., additional, Rodiles, A., additional, Merrifield, D., additional, and Oliva-Teles, A., additional
- Published
- 2015
- Full Text
- View/download PDF
50. USO DE DIFERENTES PLASTIFICANTES NA PRODUÇÃO DE BIOFILMES À BASE DE AMIDO DE PINHÃO
- Author
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DAUDT, R. M., additional, TASENDE, V. F., additional, CAFRUNI, I., additional, THYS, R. C. S., additional, CLADERA-OLIVERA, F., additional, KÜLKAMP-GUERREIRO, I. C., additional, and MARCZAK, L. D. F., additional more...
- Published
- 2015
- Full Text
- View/download PDF
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