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Your search keyword '"Guerreiro, Susana G."' showing total 27 results
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27 results on '"Guerreiro, Susana G."'

14. GLP-1R and IL-6 expression in the gastrointestinal tract of a murine model of metabolic syndrome.

Author

Costa, José, Oliveira, Sofia, Cláudia Pereira, Ana, Soares, Raquel, Baylina, Pilar, Guerreiro, Susana G., Fernandes, Rúben, and Luis, Carla

Subjects
METABOLIC syndrome, GASTROINTESTINAL system, INTERLEUKIN-6, METABOLIC models, HIGH-fat diet, GLUCOSE metabolism, INSULIN
Abstract

Background and aims: Glucose homeostasis is a critical cornerstone in both health and disease. It is described to be regulated by the balance of insulin and glucagon secretion but, this bi-hormonal perspective is long overdue since glucose homeostasis is now known to be a multi-hormonal process. Metabolic syndrome (MetS) is a cluster of metabolic features that includes impaired glucose metabolism and obesity. Obesity promotes a low chronic inflammation state due to the release of bioactive molecules like cytokines, ultimately contributing to cardiovascular disease, diabetes, and cancer. The gastrointestinal tract (GIT), namely the stomach and intestine, has a vital role not only in the food uptake and absorption but also in the production of incretin hormones, such as GLP-1. We aim to evaluate the GLP-1 receptor (GLP-1R) in the GIT of a MetS animal model and to assess whether it correlates with inflammatory levels. Material and method: The expression of GLP-1R and interleukin-6 (IL-6) was evaluated in the stomach and intestine of mice subjected to normal diet (ND) and high fat diet (HFD) by immunohistochemistry. Results: We observed that HFD fed animals presented lower levels of GLP-1R in the stomach and intestine when compared with animals fed with ND. Concomitantly, these mice expressed increased levels of IL-6. Conclusions: GLP-1R expression is inversely correlated with the expression of the pro-inflammatory cytokine IL-6. [ABSTRACT FROM AUTHOR]

Published
2022
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15. Kaempferol: a key emphasis to its anticancer potential

Author

Imran, Muhammad, Salehi, Bahare, Sharifi-Rad, Javad, Gondal, Tanweer Aslam, Saeed, Farhan, Imran, Ali, Shahbaz, Muhammad, Fokou, Patrick Valere Tsouh, Arshad, Muhammad Umair, Khan, Haroon, Guerreiro, Susana G, Martins, Natalia, Estevinho, Leticia M, Imran, Muhammad, Salehi, Bahare, Sharifi-Rad, Javad, Gondal, Tanweer Aslam, Saeed, Farhan, Imran, Ali, Shahbaz, Muhammad, Fokou, Patrick Valere Tsouh, Arshad, Muhammad Umair, Khan, Haroon, Guerreiro, Susana G, Martins, Natalia, and Estevinho, Leticia M

Abstract

A marked decrease in human cancers, including breast cancer, bone cancer, and cervical cancer, has been linked to the consumption of vegetable and fruit, and the corresponding chemoprotective effect has been associated with the presence of several active molecules, such as kaempferol. Kaempferol is a major flavonoid aglycone found in many natural products, such as beans, bee pollen, broccoli, cabbage, capers, cauliflower, chia seeds, chives, cumin, moringa leaves, endive, fennel, and garlic. Kaempferol displays several pharmacological properties, among them antimicrobial, anti-inflammatory, antioxidant, antitumor, cardioprotective, neuroprotective, and antidiabetic activities, and is being applied in cancer chemotherapy. Specifically, kaempferol-rich food has been linked to a decrease in the risk of developing some types of cancers, including skin, liver, and colon. The mechanisms of action include apoptosis, cell cycle arrest at the G2/M phase, downregulation of epithelial-mesenchymal transition (EMT)-related markers, and phosphoinositide 3-kinase/protein kinase B signaling pathways. In this sense, this article reviews data from experimental studies that investigated the links between kaempferol and kaempferol-rich food intake and cancer prevention. Even though growing evidence supports the use of kaempferol for cancer prevention, further preclinical and clinical investigations using kaempferol or kaempferol-rich foods are of pivotal importance before any public health recommendation or formulation using kaempferol.

Published
2019

19. Kaempferol: A Key Emphasis to Its Anticancer Potential

Author

Imran, Muhammad, primary, Salehi, Bahare, additional, Sharifi-Rad, Javad, additional, Aslam Gondal, Tanweer, additional, Saeed, Farhan, additional, Imran, Ali, additional, Shahbaz, Muhammad, additional, Tsouh Fokou, Patrick Valere, additional, Umair Arshad, Muhammad, additional, Khan, Haroon, additional, Guerreiro, Susana G., additional, Martins, Natália, additional, and Estevinho, Leticia M., additional

Published
2019
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