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3. 244 Application of bovine recombinant FSH (bscrFSH) in alpaca (

Author

Perez-Guerra, U. H., primary, Palomino, J. M., additional, Perez-Durand, M. G., additional, Gutiérrez-Yana, F. W., additional, Cabezas, I., additional, Hugues, F. I., additional, Parra, N. C., additional, Sanchez, O., additional, Toledo, J. R., additional, Gutiérrez-Reinoso, M. A., additional, and Garcia-Herreros, M., additional

Published
2022
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4. 245 Reproductive tract anatomical and physiological assessment by Doppler imaging in alpaca (

Author

Urviola-Sánchez, J. M., primary, Perez-Guerra, U. H., additional, Perez-Durand, M. G., additional, Palomino, J. M., additional, Bustamente-Quispe, C. W., additional, Chuctaya-Cutiri, R. J., additional, Cabezas, I., additional, Hugues, F. I., additional, Parra, N. C., additional, Sánchez, O., additional, Toledo, J. R., additional, Gutiérrez-Reinoso, M. A., additional, and García-Herreros, M., additional

Published
2022
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6. Semi-quantification and grading of amyloid PET: A project of the European Alzheimer's Disease Consortium (EADC)

Author

Chincarini, A, Peira, E, Morbelli, S, Pardini, M, Bauckneht, M, Arbizu, J, Castelo-Branco, M, Busing, K, de Mendonca, A, Didic, M, Dottorini, M, Engelborghs, S, Ferrarese, C, Frisoni, G, Garibotto, V, Guedj, E, Hausner, L, Hugon, J, Verhaeghe, J, Mecocci, P, Musarra, M, Queneau, M, Riverol, M, Santana, I, Guerra, U, Nobili, F, Chincarini A., Peira E., Morbelli S., Pardini M., Bauckneht M., Arbizu J., Castelo-Branco M., Busing K. A., de Mendonca A., Didic M., Dottorini M., Engelborghs S., Ferrarese C., Frisoni G. B., Garibotto V., Guedj E., Hausner L., Hugon J., Verhaeghe J., Mecocci P., Musarra M., Queneau M., Riverol M., Santana I., Guerra U. P., Nobili F., Chincarini, A, Peira, E, Morbelli, S, Pardini, M, Bauckneht, M, Arbizu, J, Castelo-Branco, M, Busing, K, de Mendonca, A, Didic, M, Dottorini, M, Engelborghs, S, Ferrarese, C, Frisoni, G, Garibotto, V, Guedj, E, Hausner, L, Hugon, J, Verhaeghe, J, Mecocci, P, Musarra, M, Queneau, M, Riverol, M, Santana, I, Guerra, U, Nobili, F, Chincarini A., Peira E., Morbelli S., Pardini M., Bauckneht M., Arbizu J., Castelo-Branco M., Busing K. A., de Mendonca A., Didic M., Dottorini M., Engelborghs S., Ferrarese C., Frisoni G. B., Garibotto V., Guedj E., Hausner L., Hugon J., Verhaeghe J., Mecocci P., Musarra M., Queneau M., Riverol M., Santana I., Guerra U. P., and Nobili F.

Abstract

Background: amyloid-PET reading has been classically implemented as a binary assessment, although the clinical experience has shown that the number of borderline cases is non negligible not only in epidemiological studies of asymptomatic subjects but also in naturalistic groups of symptomatic patients attending memory clinics. In this work we develop a model to compare and integrate visual reading with two independent semi-quantification methods in order to obtain a tracer-independent multi-parametric evaluation. Methods: We retrospectively enrolled three cohorts of cognitively impaired patients submitted to 18 F-florbetaben (53 subjects), 18 F-flutemetamol (62 subjects), 18 F-florbetapir (60 subjects)PET/CT respectively, in 6 European centres belonging to the EADC. The 175 scans were visually classified as positive/negative following approved criteria and further classified with a 5-step grading as negative, mild negative, borderline, mild positive, positive by 5 independent readers, blind to clinical data. Scan quality was also visually assessed and recorded. Semi-quantification was based on two quantifiers: the standardized uptake value (SUVr)and the ELBA method. We used a sigmoid model to relate the grading with the quantifiers. We measured the readers accord and inconsistencies in the visual assessment as well as the relationship between discrepancies on the grading and semi-quantifications. Conclusion: It is possible to construct a map between different tracers and different quantification methods without resorting to ad-hoc acquired cases. We used a 5-level visual scale which, together with a mathematical model, delivered cut-offs and transition regions on tracers that are (largely)independent from the population. All fluorinated tracers appeared to have the same contrast and discrimination ability with respect to the negative-to-positive grading. We validated the integration of both visual reading and different quantifiers in a more robust framework thus bri

Published
2019

8. Evaluation of age and sex-related metabolic changes in healthy subjects: An italian brain 18f-fdg pet study

Author

Allocca, Marialuisa, Linguanti, F., Calcagni, Maria Lucia, Cistaro, A., Gaudieri, V., Guerra, U. P., Morbelli, S., Nobili, F., Pappata, S., Sestini, S., Volterrani, D., Berti, V., Allocca M., Calcagni M. L. (ORCID:0000-0002-0805-8245), Allocca, Marialuisa, Linguanti, F., Calcagni, Maria Lucia, Cistaro, A., Gaudieri, V., Guerra, U. P., Morbelli, S., Nobili, F., Pappata, S., Sestini, S., Volterrani, D., Berti, V., Allocca M., and Calcagni M. L. (ORCID:0000-0002-0805-8245)

Abstract

Background: 18F-fluorodeoxyglucose (18F-FDG) positron-emission-tomography (PET) allows detection of cerebral metabolic alterations in neurological diseases vs. normal aging. We assess age-and sex-related brain metabolic changes in healthy subjects, exploring impact of activity normalization methods. Methods: brain scans of Italian Association of Nuclear Medicine normative database (151 subjects, 67 Males, 84 Females, aged 20–84) were selected. Global mean, white matter, and pons activity were explored as normalization reference. We performed voxel-based and ROI analyses using SPM12 and IBM-SPSS software. Results: SPM proved a negative correlation between age and brain glucose metabolism involving frontal lobes, anterior-cingulate and insular cortices bilaterally. Narrower clusters were detected in lateral parietal lobes, precuneus, temporal pole and medial areas bilaterally. Normalizing on pons activity, we found a more significant negative correlation and no positive one. ROIs analysis confirmed SPM results. Moreover, a significant age × sex interaction effect was revealed, with worse metabolic reduction in posterior-cingulate cortices in females than males, especially in post-menopausal age. Conclusions: this study demonstrated an age-related metabolic reduction in frontal lobes and in some parieto-temporal areas more evident in females. Results suggested pons as the most appropriate normalization reference. Knowledge of age-and sex-related cerebral metabolic changes is critical to correctly interpreting brain 18F-FDG PET imaging.

Published
2021

12. Emerging topics and practical aspects for an appropriate use of amyloid PET in the current Italian context

Author

Nobili, F., Cagnin, A., Calcagni, M. L. (ORCID:0000-0002-0805-8245), Chincarini, A., Guerra, U. P., Morbelli, S., Padovani, A., Paghera, B., Pappata, S., Parnetti, L., Sestini, S., Schillaci, O., Nobili, F., Cagnin, A., Calcagni, M. L. (ORCID:0000-0002-0805-8245), Chincarini, A., Guerra, U. P., Morbelli, S., Padovani, A., Paghera, B., Pappata, S., Parnetti, L., Sestini, S., and Schillaci, O.

Abstract

In May 2017 some representatives of the Italian nuclear medicine and neurological communities spontaneously met to discuss the issues emerged during the first two years of routine application of amyloid PET with fluorinated radiopharmaceuticals in the real world. The limitations of a binary classification of scans, the possibility to obtain early images as a surrogate marker of regional cerebral bloos flow, the need for (semi-)quantification and, thus, the opportunity of ranking brain amyloidosis, the correlation with Aβ42 levels in the cerebrospinal fluid, the occurrence and biological meaning of uncertain/boderline scans, the issue of incidental amyloidosis, the technical pittfalls leading to false negative/positive results, the position of the tool in the diagnostic flow-chart in the national reality, are the main topics that have been discussed. Also, a card to justify the examination to be filled by the dementia specialist and a card for the nuclear medicine physician to report the exam in detail have been approved and are available in the web, which should facilitate the creation of a national register, as previewed by the 2015 intersocietal recom-mendation on the use of amyloid PET in Italy. The content of this discussion could stimulate both public institutions and companies to support further research on these topics.

Published
2019

13. The role of molecular imaging in the frame of the revised dementia with Lewy body criteria

Author

Sestini, S., Alongi, P., Berti, V., Calcagni, Maria Lucia, Cecchin, D., Chiaravalloti, A., Chincarini, A., Cistaro, A., Guerra, U. P., Pappata, S., Tiraboschi, P., Nobili, Raffaele, Calcagni M. L. (ORCID:0000-0002-0805-8245), Nobili F., Sestini, S., Alongi, P., Berti, V., Calcagni, Maria Lucia, Cecchin, D., Chiaravalloti, A., Chincarini, A., Cistaro, A., Guerra, U. P., Pappata, S., Tiraboschi, P., Nobili, Raffaele, Calcagni M. L. (ORCID:0000-0002-0805-8245), and Nobili F.

Abstract

Introduction: Recommendations about clinical and pathologic diagnosis of dementia with Lewy bodies (DLB) have been recently refined by the DLB Consortium. Substantial new information has been incorporated with increased diagnostic weighting given to molecular imaging biomarkers. The present work attempted to present a comprehensive evaluation of the role of molecular imaging in the frame of the revised DLB criteria. Methods: To this end, we briefly review the molecular imaging tools in the fourth Consensus report of the DLB Consortium, highlighting several indicative and supportive surrogate markers, including I-123 brain dopamine transporter (DaT), I-123 mIBG cardiac norepinephrine transporter (NeT) and brain F-18 fluorodeoxyglucose (FDG) imaging, as the main way to increase accuracy of ante-mortem diagnosis of probable or possible DLB. Results: Along with main neuropathological and clinical issues, we focus on the diagnostic performance and appropriate use of current available items included in the index by nuclear medicine physicians, namely a low DaT uptake, a low NeT expression in myocardial tissue, and reduced parieto-occipital metabolism on brain FDG-PET. Moreover, a critical summary of the current state of the art in pathological validation of other biomarkers including amyloid and tau-PET imaging is provided. Discussion: DLB Consortium clearly states that clinical diagnosis in clinical routine is suboptimal and gives more weight to molecular imaging biomarkers to offer a more objective information. Along with DaT, mIBG and FDG techniques, brain PET with more specific radiotracers could open a new scenario for an accurate evaluation of biomarkers involved in DLB.

Published
2019

14. Do beliefs about the pathogenetic role of amyloid affect the interpretation of amyloid PET in the clinic?

Author

Boccardi, M, Altomare, D, Ferrari, C, Festari, C, Antelmi, L, Pievani, M, Tarallo, A, Muscio, C, Guerra, U, Paghera, B, Padovani, A, Frisoni, G, Zanetti, O, Anzola, G, Bertocchi, M, Chito, E, Galluzzi, S, Geroldi, C, Lussignoli, G, Mattioli, F, Moretti, D, Pizzocaro, C, Borroni, B, Rozzini, L, Prelle, A, Gennuso, M, Villani, D, Raimondi, M, Gentile, S, Bellelli, G, Morandi, A, Turco, R, Bellandi, D, Carbone, P, Abruzzi, L, Bettoni, L, Bianchetti, A, Facchi, E, Di Fazio, I, Turla, M, Cotelli, M, Volta, G, Bigni, B, Bilotti, G, Vollaro, S, Rozzini, R, Boffelli, S, Cappuccio, M, Conti, M, Guizzetti, G, Defanti, C, Mirabile, D, Fascendini, S, Manzoni, L, Salvi, G, Belotti, G, Cavaliere, S, Fiacco, F, Valente, L, Ciccone, A, Lanari, A, Selletti, L, Palmerini, F, Avanzi, S, Vezzadini, G, Boccardi M., Altomare D., Ferrari C., Festari C., Antelmi L., Pievani M., Tarallo A., Muscio C., Guerra U. P., Paghera B., Padovani A., Frisoni G. B., Zanetti O., Anzola G. P., Bertocchi M., Chito E., Galluzzi S., Geroldi C., Lussignoli G., Mattioli F., Moretti D., Pizzocaro C., Borroni B., Rozzini L., Prelle A., Gennuso M., Villani D., Raimondi M. C., Gentile S., Bellelli G., Morandi A., Turco R., Bellandi D., Carbone P., Abruzzi L., Bettoni L., Bianchetti A., Facchi E., Di Fazio I., Turla M., Cotelli M. S., Volta G. D., Bigni B., Bilotti G., Vollaro S., Rozzini R., Boffelli S., Cappuccio M., Conti M. Z., Guizzetti G., Defanti C., Mirabile D., Fascendini S., Manzoni L., Salvi G. P., Belotti G., Cavaliere S., Fiacco F., Valente L., Ciccone A., Lanari A., Selletti L., Palmerini F., Avanzi S., Vezzadini G., Boccardi, M, Altomare, D, Ferrari, C, Festari, C, Antelmi, L, Pievani, M, Tarallo, A, Muscio, C, Guerra, U, Paghera, B, Padovani, A, Frisoni, G, Zanetti, O, Anzola, G, Bertocchi, M, Chito, E, Galluzzi, S, Geroldi, C, Lussignoli, G, Mattioli, F, Moretti, D, Pizzocaro, C, Borroni, B, Rozzini, L, Prelle, A, Gennuso, M, Villani, D, Raimondi, M, Gentile, S, Bellelli, G, Morandi, A, Turco, R, Bellandi, D, Carbone, P, Abruzzi, L, Bettoni, L, Bianchetti, A, Facchi, E, Di Fazio, I, Turla, M, Cotelli, M, Volta, G, Bigni, B, Bilotti, G, Vollaro, S, Rozzini, R, Boffelli, S, Cappuccio, M, Conti, M, Guizzetti, G, Defanti, C, Mirabile, D, Fascendini, S, Manzoni, L, Salvi, G, Belotti, G, Cavaliere, S, Fiacco, F, Valente, L, Ciccone, A, Lanari, A, Selletti, L, Palmerini, F, Avanzi, S, Vezzadini, G, Boccardi M., Altomare D., Ferrari C., Festari C., Antelmi L., Pievani M., Tarallo A., Muscio C., Guerra U. P., Paghera B., Padovani A., Frisoni G. B., Zanetti O., Anzola G. P., Bertocchi M., Chito E., Galluzzi S., Geroldi C., Lussignoli G., Mattioli F., Moretti D., Pizzocaro C., Borroni B., Rozzini L., Prelle A., Gennuso M., Villani D., Raimondi M. C., Gentile S., Bellelli G., Morandi A., Turco R., Bellandi D., Carbone P., Abruzzi L., Bettoni L., Bianchetti A., Facchi E., Di Fazio I., Turla M., Cotelli M. S., Volta G. D., Bigni B., Bilotti G., Vollaro S., Rozzini R., Boffelli S., Cappuccio M., Conti M. Z., Guizzetti G., Defanti C., Mirabile D., Fascendini S., Manzoni L., Salvi G. P., Belotti G., Cavaliere S., Fiacco F., Valente L., Ciccone A., Lanari A., Selletti L., Palmerini F., Avanzi S., and Vezzadini G.

Abstract

Background: Beliefs of dementia experts about the pathogenic role of amyloid in Alzheimer's disease (AD) may affect the use of amyloid positron emission tomography (PET). Objective:To assess the role attributed to amyloid in AD pathogenesis by Italian dementia experts, and whether this modulates the impact of amyloid PET results in their diagnostic workup. Methods: 22 dementia experts rated their beliefs about the pathogenic role of amyloid. Then, we asked them to rate the probability of change in diagnosis based on the result of amyloid PET for 7 case vignettes, depicting patients who initially received a diagnosis based on a comprehensive workup and later received amyloid PET results consistent or inconsistent with the clinical picture. Results: 55% of the experts assigned a dominant role to amyloid, and 32% attributed a similar role to amyloid and tau in AD pathogenesis. The probability of change in diagnosis ranged from 17% (SD = 21.6) for cases with consistent to 51% (SD = 34) for cases with inconsistent PET versus clinical data. Diagnostic change was not biased by the clinicians' beliefs about AD pathogenesis. Conclusions: This work supports an unbiased interpretation of amyloid PET across different beliefs about the pathogenic role of amyloid, and a belief -independent reluctance to change diagnosis in cases where change is expected and recommended. (C) 2015 S. Karger AG, Basel

Published
2016

15. Assessment of the incremental diagnostic value of florbetapir F 18 imaging in patients with cognitive impairment: The incremental diagnostic value of amyloid PET with [18F]-florbetapir (INDIA-FBP) study

Author

Boccardi, M, Altomare, D, Ferrari, C, Festari, C, Guerra, U, Paghera, B, Pizzocaro, C, Lussignoli, G, Geroldi, C, Zanetti, O, Cotelli, M, Turla, M, Borroni, B, Rozzini, L, Mirabile, D, Defanti, C, Gennuso, M, Prelle, A, Gentile, S, Morandi, A, Vollaro, S, Volta, G, Bianchetti, A, Conti, M, Cappuccio, M, Carbone, P, Bellandi, D, Abruzzi, L, Bettoni, L, Villani, D, Raimondi, M, Lanari, A, Ciccone, A, Facchi, E, Di Fazio, I, Rozzini, R, Boffelli, S, Manzoni, L, Salvi, G, Cavaliere, S, Belotti, G, Avanzi, S, Pasqualetti, P, Muscio, C, Padovani, A, Frisoni, G, Antelmi, L, Galluzzi, S, Pievani, M, Redolfi, A, Tarallo, A, Arora, A, Bertocchi, M, Chito, E, Moretti, D, Giubbini, R, Rodella, C, Camoni, L, Massetti, V, Andreoli, M, Bellelli, G, Fascendini, S, Mattioli, F, Turco, R, Vezzadini, G, Raimondi, V, Mondini, S, Zanacchi, E, Grigolo, M, Pezzini, A, Bilotti, G, Bigni, B, Zavarise, P, Ngonga, G, Anzola, G, Turrone, R, Guizzetti, G, Zanetti, M, Boccardi M., Altomare D., Ferrari C., Festari C., Guerra U. P., Paghera B., Pizzocaro C., Lussignoli G., Geroldi C., Zanetti O., Cotelli M. S., Turla M., Borroni B., Rozzini L., Mirabile D., Defanti C., Gennuso M., Prelle A., Gentile S., Morandi A., Vollaro S., Volta G. D., Bianchetti A., Conti M. Z., Cappuccio M., Carbone P., Bellandi D., Abruzzi L., Bettoni L., Villani D., Raimondi M. C., Lanari A., Ciccone A., Facchi E., Di Fazio I., Rozzini R., Boffelli S., Manzoni L., Salvi G. P., Cavaliere S., Belotti G., Avanzi S., Pasqualetti P., Muscio C., Padovani A., Frisoni G. B., Antelmi L., Galluzzi S., Pievani M., Redolfi A., Tarallo A., Arora A., Bertocchi M., Chito E., Moretti D. V., Giubbini R., Rodella C., Camoni L., Massetti V., Andreoli M., Bellelli G., Fascendini S., Mattioli F., Turco R., Vezzadini G., Raimondi V., Mondini S., Zanacchi E. C., Grigolo M., Pezzini A., Bilotti G., Bigni B., Zavarise P., Ngonga G., Anzola G. P., Turrone R., Guizzetti G., Zanetti M., Boccardi, M, Altomare, D, Ferrari, C, Festari, C, Guerra, U, Paghera, B, Pizzocaro, C, Lussignoli, G, Geroldi, C, Zanetti, O, Cotelli, M, Turla, M, Borroni, B, Rozzini, L, Mirabile, D, Defanti, C, Gennuso, M, Prelle, A, Gentile, S, Morandi, A, Vollaro, S, Volta, G, Bianchetti, A, Conti, M, Cappuccio, M, Carbone, P, Bellandi, D, Abruzzi, L, Bettoni, L, Villani, D, Raimondi, M, Lanari, A, Ciccone, A, Facchi, E, Di Fazio, I, Rozzini, R, Boffelli, S, Manzoni, L, Salvi, G, Cavaliere, S, Belotti, G, Avanzi, S, Pasqualetti, P, Muscio, C, Padovani, A, Frisoni, G, Antelmi, L, Galluzzi, S, Pievani, M, Redolfi, A, Tarallo, A, Arora, A, Bertocchi, M, Chito, E, Moretti, D, Giubbini, R, Rodella, C, Camoni, L, Massetti, V, Andreoli, M, Bellelli, G, Fascendini, S, Mattioli, F, Turco, R, Vezzadini, G, Raimondi, V, Mondini, S, Zanacchi, E, Grigolo, M, Pezzini, A, Bilotti, G, Bigni, B, Zavarise, P, Ngonga, G, Anzola, G, Turrone, R, Guizzetti, G, Zanetti, M, Boccardi M., Altomare D., Ferrari C., Festari C., Guerra U. P., Paghera B., Pizzocaro C., Lussignoli G., Geroldi C., Zanetti O., Cotelli M. S., Turla M., Borroni B., Rozzini L., Mirabile D., Defanti C., Gennuso M., Prelle A., Gentile S., Morandi A., Vollaro S., Volta G. D., Bianchetti A., Conti M. Z., Cappuccio M., Carbone P., Bellandi D., Abruzzi L., Bettoni L., Villani D., Raimondi M. C., Lanari A., Ciccone A., Facchi E., Di Fazio I., Rozzini R., Boffelli S., Manzoni L., Salvi G. P., Cavaliere S., Belotti G., Avanzi S., Pasqualetti P., Muscio C., Padovani A., Frisoni G. B., Antelmi L., Galluzzi S., Pievani M., Redolfi A., Tarallo A., Arora A., Bertocchi M., Chito E., Moretti D. V., Giubbini R., Rodella C., Camoni L., Massetti V., Andreoli M., Bellelli G., Fascendini S., Mattioli F., Turco R., Vezzadini G., Raimondi V., Mondini S., Zanacchi E. C., Grigolo M., Pezzini A., Bilotti G., Bigni B., Zavarise P., Ngonga G., Anzola G. P., Turrone R., Guizzetti G., and Zanetti M.

Abstract

IMPORTANCE Cerebral amyloidosis is a key abnormality in Alzheimer disease (AD) and can be detected in vivo with positron emission tomography (PET) ligands. Although amyloid PET has clearly demonstrated analytical validity, its clinical utility is debated. OBJECTIVE To evaluate the incremental diagnostic value of amyloid PET with florbetapir F 18 in addition to the routine clinical diagnostic assessment of patients evaluated for cognitive impairment. DESIGN, SETTING, AND PARTICIPANTS The Incremental Diagnostic Value ofAmyloid PET With [18F]-Florbetapir (INDIA-FBP) Study is a multicenter study involving 18 AD evaluation units from eastern Lombardy, Northern Italy, 228 consecutive adults with cognitive impairmentwere evaluated for AD and other causes of cognitive decline, with a prescan diagnostic confidence of AD between 15%and 85%. Participants underwent routine clinical and instrumental diagnostic assessment. A prescan diagnosiswas made, diagnostic confidencewas estimated, and drug treatmentwas provided. At the time of thisworkup, an amyloid PET/computed tomographic scanwas performed, and the resultwas communicated to physicians afterworkup completion. Physicianswere asked to review the diagnosis, diagnostic confidence, and treatment after the scan. The studywas conducted from August 5, 2013, to December 31, 2014. MAIN OUTCOMES AND MEASURES Primary outcomeswere prescan to postscan changes of diagnosis, diagnostic confidence, and treatment. RESULTS Of the 228 participants, 107 (46%) were male; mean (SD) age was 70.5 (7) years. Diagnostic change occurred in 46 patients (79%) having both a previous diagnosis of AD and an amyloid-negative scan (P < .001) and in 16 (53%) of those with non-AD diagnoses and an amyloid-positive scan (P < .001). Diagnostic confidence in AD diagnosis increased by 15.2%in amyloid-positive (P < .001; effect size Cohen d = 1.04) and decreased by 29.9%in amyloid-negative (P < .001; d = -1.19) scans. Acetylcholinesterase inhibitors and

Published
2016

17. Do Beliefs about the Pathogenetic Role of Amyloid Affect the Interpretation of Amyloid PET in the Clinic

Author

Boccardi M., Altomare D., Ferrari C., Festari C., Antelmi L., Pievani M., Tarallo A., Muscio C., Guerra U. P., Paghera B., Padovani A., Frisoni G. B., Zanetti O., Anzola G. P., Bertocchi M., Chito E., Galluzzi S., Geroldi C., Lussignoli G., Mattioli F., Moretti D., Pizzocaro C., Borroni B., Rozzini L., Prelle A., Gennuso M., Villani D., Raimondi M. C., Gentile S., Bellelli G., Morandi A., Turco R., Bellandi D., Carbone P., Abruzzi L., Bettoni L., Bianchetti A., Facchi E., Di Fazio I., Turla M., Cotelli M. S., Volta G. D., Bigni B., Bilotti G., Vollaro S., Rozzini R., Boffelli S., Cappuccio M., Conti M. Z., Guizzetti G., Defanti C., Mirabile D., Fascendini S., Manzoni L., Salvi G. P., Belotti G., Cavaliere S., Fiacco F., Valente L., Ciccone A., Lanari A., Selletti L., Palmerini F., Avanzi S., Vezzadini G., Boccardi, M, Altomare, D, Ferrari, C, Festari, C, Antelmi, L, Pievani, M, Tarallo, A, Muscio, C, Guerra, U, Paghera, B, Padovani, A, Frisoni, G, Zanetti, O, Anzola, G, Bertocchi, M, Chito, E, Galluzzi, S, Geroldi, C, Lussignoli, G, Mattioli, F, Moretti, D, Pizzocaro, C, Borroni, B, Rozzini, L, Prelle, A, Gennuso, M, Villani, D, Raimondi, M, Gentile, S, Bellelli, G, Morandi, A, Turco, R, Bellandi, D, Carbone, P, Abruzzi, L, Bettoni, L, Bianchetti, A, Facchi, E, Di Fazio, I, Turla, M, Cotelli, M, Volta, G, Bigni, B, Bilotti, G, Vollaro, S, Rozzini, R, Boffelli, S, Cappuccio, M, Conti, M, Guizzetti, G, Defanti, C, Mirabile, D, Fascendini, S, Manzoni, L, Salvi, G, Belotti, G, Cavaliere, S, Fiacco, F, Valente, L, Ciccone, A, Lanari, A, Selletti, L, Palmerini, F, Avanzi, S, and Vezzadini, G

Subjects
0301 basic medicine, Amyloid, Attitude of Health Personnel, Tau Proteins/metabolism, Amyloid pet, tau Proteins, Pilot Projects, Disease, Affect (psychology), Amyloid/metabolism, Diagnosis, Differential, 03 medical and health sciences, ddc:616.89, Alzheimer's disease pathogenesis, Amyloid positron emission tomography, Differential diagnosis, Incremental diagnostic value, 0302 clinical medicine, Neuroimaging, Positron-Emission Tomography/psychology, Alzheimer Disease, Physicians, Physicians/psychology, mental disorders, Diagnosis, Medicine, Dementia, Humans, business.industry, Alzheimer Disease/diagnosis/diagnostic imaging/metabolism, medicine.disease, eye diseases, 030104 developmental biology, Neurology, Italy, Positron-Emission Tomography, Differential, sense organs, Neurology (clinical), Alzheimer's disease, business, Neuroscience, 030217 neurology & neurosurgery
Abstract

Background: Beliefs of dementia experts about the pathogenic role of amyloid in Alzheimer's disease (AD) may affect the use of amyloid positron emission tomography (PET). Objective: To assess the role attributed to amyloid in AD pathogenesis by Italian dementia experts, and whether this modulates the impact of amyloid PET results in their diagnostic workup. Methods: 22 dementia experts rated their beliefs about the pathogenic role of amyloid. Then, we asked them to rate the probability of change in diagnosis based on the result of amyloid PET for 7 case vignettes, depicting patients who initially received a diagnosis based on a comprehensive workup and later received amyloid PET results consistent or inconsistent with the clinical picture. Results: 55% of the experts assigned a dominant role to amyloid, and 32% attributed a similar role to amyloid and tau in AD pathogenesis. The probability of change in diagnosis ranged from 17% (SD = 21.6) for cases with consistent to 51% (SD = 34) for cases with inconsistent PET versus clinical data. Diagnostic change was not biased by the clinicians' beliefs about AD pathogenesis. Conclusions: This work supports an unbiased interpretation of amyloid PET across different beliefs about the pathogenic role of amyloid, and a belief-independent reluctance to change diagnosis in cases where change is expected and recommended.

Published
2016

18. Association of postoperative delirium with markers of neurodegeneration and brain amyloidosis: a pilot study

Author

Rolandi, E, Cavedo, E, Pievani, M, Galluzzi, S, Ribaldi, F, Buckley, C, Cunningham, C, Guerra, U, Musarra, M, Morzenti, S, Magnaldi, S, Patassini, M, Terragnoli, F, Matascioli, L, Franzoni, S, Annoni, G, Carnevali, L, Bellelli, G, Frisoni, G, Rolandi, E, Cavedo, E, Pievani, M, Galluzzi, S, Ribaldi, F, Buckley, C, Cunningham, C, Guerra, U, Musarra, M, Morzenti, S, Magnaldi, S, Patassini, M, Terragnoli, F, Matascioli, L, Franzoni, S, Annoni, G, Carnevali, L, Bellelli, G, and Frisoni, G

Abstract

The aim of the study was to investigate the association between postoperative delirium (POD) and in vivo markers of Alzheimer's disease pathology in nondemented hip fracture surgery patients. POD was assessed with the Confusion Assessment Method. Amyloid load was quantified on 18F-Flutemetamol positron emission tomography images as standardized uptake value ratio. Secondary outcome measures were gray matter volumes, white matter integrity, and functional connectivity at rest. All the patients with POD (POD+, N = 5) were amyloid negative (standardized uptake value ratio <0.59), whereas 6 out of 11 patients without POD (POD−) showed brain amyloid positivity. POD+ compared to POD− displayed: lower gray matter volumes in the amygdala (p = 0.003), in the middle temporal gyrus and in the anterior cingulate cortex (p < 0.001), increased diffusivity in the genu of the corpus callosum and in the anterior corona radiata (p < 0.05), and higher functional connectivity within the default mode network (p < 0.001). POD patients showed altered gray and white matter integrity in the fronto-limbic regions in absence of brain amyloidosis. Based on this preliminary investigation, delirium pathophysiology might be independent of Alzheimer's disease. Future studies on larger samples are needed to confirm this hypothesis.

Published
2018

20. P4669The advantage of echocardiographic RV wall thickness over ECG criteria of RVH for detection of confirmed pulmonary hypertension

Author

Wierzbowska-Drabik, K, primary, Gargani, L, additional, Cieslik-Guerra, U, additional, Kurpesa, M, additional, Uznanska-Loch, B, additional, Sobczak, M, additional, Trzos, E, additional, Szymczyk, E, additional, Rechcinski, T, additional, Nowak, B, additional, Nowakowski, R, additional, and Kasprzak, J, additional

Published
2018
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21. Supporting evidence for using biomarkers in the diagnosis of MCI due to AD

Author

Galluzzi, Samantha, Geroldi, Cristina, Amicucci, Giovanni, Bocchio Chiavetto, Luisella, Bonetti, Matteo, Bonvicini, Cristian, Cotelli, Maria, Ghidoni, Roberta, Paghera, Barbara, Zanetti, Orazio, Frisoni, Giovanni B, Archetti, S., Benussi, L., Binetti, G., Canu, E., Caobelli, F., Cavedo, E., Chitò, E., Costardi, D., Gennarelli, Massimo, Giubbini, R., Guerra, U. P., Kuffenschin, G., Lussignoli, G., Moretti, D., Orlandini, A., Parapini, M., Paternicò, D., Porteri, C., Romano, M., Rosini, S., Scarpazza, C., Villa, I., and Zanardini, Roberta

Subjects
Male, Oncology, medicine.medical_specialty, Pathology, Neurology, tau Proteins, Disease, Neuropsychological Tests, Dynamic model, Apolipoproteins E, Alzheimer Disease, Fluorodeoxyglucose F18, Internal medicine, mental disorders, medicine, Humans, Dementia, Cognitive Dysfunction, Genetic Testing, Aged, Neuroradiology, Analysis of Variance, Amyloid beta-Peptides, medicine.diagnostic_test, Alzheimer’s disease, Biomarkers, Mild cognitive impairment, Female, Magnetic Resonance Imaging, Middle Aged, Peptide Fragments, Positron-Emission Tomography, Neurology (clinical), Magnetic resonance imaging, medicine.disease, Positron emission tomography, Biomarker (medicine), Alzheimer's disease, Psychology
Abstract

The aim of this study is to support the use of biomarkers in the diagnosis of mild cognitive impairment (MCI) due to Alzheimer’s disease (AD) according to the revised NIA-AA diagnostic criteria. We compared clinical features and conversion to AD and other dementias among groups of MCI patients with different abnormal biomarker profiles. In this study, we enrolled 58 patients with MCI, and for each of them AD biomarkers (CSF Abeta42 and tau, temporoparietal hypometabolism on 18F-FDG PET, and hippocampal volume) were collected. Patients were divided into three groups: (i) no abnormal biomarker, (ii) AD biomarker pattern (including three subgroups of early = only abnormal Abeta42, intermediate = abnormal Abeta42 and FDG PET or tau, and late = abnormal Abeta42, FDG PET or tau, and HV), and (iii) any other biomarker combination. MCI patients with AD biomarker pattern had lower behavioural disturbances than patients with any other biomarker combination (p < 0.0005). This group also showed lower performance on verbal and non-verbal memory than the other two groups (p = 0.07 and p = 0.004, respectively). Within the three subgroups with AD biomarker patterns we observed a significant trend toward a higher rate of conversion to dementia (p for trend = 0.006). With regard to dementia conversion, 100 % of patients with an AD biomarker pattern developed AD, but none of the patients with no abnormal biomarker and 27 % of patients with any other biomarker combination (p = 0.002) did so. We also described some clinical cases representative for each of these three groups. The results of this study provide evidence in favour of the use of biomarkers for the diagnosis of MCI due to AD, in line with recently published research criteria.

Published
2012

24. Poster Session 3 : Tuesday 5 May 2015, 08

Author

Ferreira, Mjv, Robalo, M M, Saraiva, T, Cunha, M J, Goncalves, L, Albuquerque, A, Ramos, D, Costa, G, Lima, J, Pego, M, Peovska, I, Davceva Pavlovska, J, Pop Gorceva, D, Zdravkovska, M, Vavlukis, M, Kostova, N, Bulugahapitiya, D S, Feben, A, Avison, M, Foley, J, Martin, J, De Graaf, M A, Van Den Hoogen, I J, Leen, A C, Kharagjitsingh, A V, Kroft, L J, Jukema, J W, Bax, J J, Scholte, A J, Patel, K, Mahan, M, Ananthasubramaniam, K, Durmus Altun, G, Alpay, M, Altun, A, Andreini, D, Pontone, G, Mushtaq, S, Bertella, E, Conte, E, Segurini, C, Volpato, V, Petulla, M, Baggiano, A, Pepi, M, Van Dijk, J D, Huizing, E D, Jager, P L, Slump, C H, Ottervanger, J P, Van Dalen, J A, Yambao, E, Calleja, H B, Sibulo, A S, Ramirez Moreno, A, Siles Rubio, J R, Noureddine, M, Munoz-Bellido, J, Bravo, R, Martinez, F, Valle, A, Milan, A, Inigo-Garcia, L, Velasco, T, Ramaiah, V L, Devanbu, J S, Taywade, S K, Hejjaji, V S, Zafrir, N, Bental, T, Gutstein, A, Solodky, A, Mats, I, Kornowski, R, Lagan, J, Hasleton, J, Meah, M, Mcshane, J, Trent, R, Massalha, S, Israel, O, Koskosi, A, Kopelovich, M, Marai, I, Venuraju, S, Jeevarethinam, A, Dumo, A, Ruano, S, Darko, D, Cohen, M, Nair, D, Rosenthal, M, Rakhit, R, Lahiri, A, Pizzi, M N, Roque, A, Fernandez-Hidalgo, N, Cuellar-Calabria, H, Gonzalez-Alujas, M T, Oristrell, G, Rodriguez-Palomares, J, Tornos, P, Aguade-Bruix, S, Smettei, O, Abazid, R, Ahmed, W M K, Samy, W, Behairy, N, Tayeh, O, Hassan, A, Berezin, A, Kremzer, A, Samura, T, Berezina, T, Scrima, G, Bertuccio, G, Canseco Nadia, Ncl, Cruz Raul, C R, Gonzalez Cristian, G C, Hernandez Salvador, S H, Alexanderson Erick, Ear, Zerahn, B, Shugushev, Z, Maximkin, D, Chepurnoy, A, Volkova, O, Tsedenova, A, Faibushevich, A, Baranovich, V, Yoshida, H, Mizukami, A, Matsumura, A, Keller, M, Silber, S, Falcao, A, Imada, R, Azouri, L O, Giorgi, McP, Santos, R D, Mello, S L, Kalil Filho, R, Meneghetti, J C, Chalela, W A, Kanni, L, Ohrman, T, Nygren, A T, Irabi, R D, Parisotto, T, Soares, J, Burrell, S, Lo, C, Zavadovskyi, K, Gulya, M, Lishmanov, Y U, Amin, A, Kandeel, Ahmed, Shaban, Mahmud, Nawito, Zeinab, Caobelli, F, Soffientini, A, Thackeray, J T, Bengel, F M, Pizzocaro, C, Guerra, U P, Hellberg, S E, Silvola, Jmu, Kiugel, M, Liljenback, H, Savisto, N, Thiele, A, Laine, Vjo, Knuuti, J, Roivainen, A, Saraste, A, Ismail, B, Hadizad, T, Dekemp, Rob, Beanlands, Rob, Dasilva, J N, Hyafil, F, Sorbets, E, Duchatelle, V, Rouzet, F, Le Guludec, D, Feldman, L, Martire, V D, De Pierris, C, Martire, M V, Pis Diez, E R, Ramaiah, V, Lebasnier, A, Legallois, D, Peyronnet, D, Desmonts, C, Zalcman, G, Bienvenu, B, Agostini, D, Manrique, A, Solomyanyy, V, Mintale, I, Zabunova, M, Narbute, I, Ratniece, M, Jakobsons, E, Kaire, K, Kamzola, G, Briede, I, Jegere, S, Erglis, A, Mostafa, S, Abdelkader, M, Abdelkader, H, Abdelkhlek, S, Khairy, E, Huidu, S, Popescu, A, Lacau, S, Huidu, A, Dimulescu, D, Sayed, S, Al Harby, F, Habeeb, A, Saqqah, H, Merganiab, S, Selvanayagam, J, Harms, H J, Tolbod, L P, Hansson, N H, Kero, T, Orndahl, L H, Kim, W Y, Bouchelouche, K, Wiggers, H, Frokiaer, J, Sorensen, J, Tolbod, L, Hansen, E, Zaremba, T, Kero, Tanja, Sörensen, Jens, Ferreira, Mjv, Robalo, M M, Saraiva, T, Cunha, M J, Goncalves, L, Albuquerque, A, Ramos, D, Costa, G, Lima, J, Pego, M, Peovska, I, Davceva Pavlovska, J, Pop Gorceva, D, Zdravkovska, M, Vavlukis, M, Kostova, N, Bulugahapitiya, D S, Feben, A, Avison, M, Foley, J, Martin, J, De Graaf, M A, Van Den Hoogen, I J, Leen, A C, Kharagjitsingh, A V, Kroft, L J, Jukema, J W, Bax, J J, Scholte, A J, Patel, K, Mahan, M, Ananthasubramaniam, K, Durmus Altun, G, Alpay, M, Altun, A, Andreini, D, Pontone, G, Mushtaq, S, Bertella, E, Conte, E, Segurini, C, Volpato, V, Petulla, M, Baggiano, A, Pepi, M, Van Dijk, J D, Huizing, E D, Jager, P L, Slump, C H, Ottervanger, J P, Van Dalen, J A, Yambao, E, Calleja, H B, Sibulo, A S, Ramirez Moreno, A, Siles Rubio, J R, Noureddine, M, Munoz-Bellido, J, Bravo, R, Martinez, F, Valle, A, Milan, A, Inigo-Garcia, L, Velasco, T, Ramaiah, V L, Devanbu, J S, Taywade, S K, Hejjaji, V S, Zafrir, N, Bental, T, Gutstein, A, Solodky, A, Mats, I, Kornowski, R, Lagan, J, Hasleton, J, Meah, M, Mcshane, J, Trent, R, Massalha, S, Israel, O, Koskosi, A, Kopelovich, M, Marai, I, Venuraju, S, Jeevarethinam, A, Dumo, A, Ruano, S, Darko, D, Cohen, M, Nair, D, Rosenthal, M, Rakhit, R, Lahiri, A, Pizzi, M N, Roque, A, Fernandez-Hidalgo, N, Cuellar-Calabria, H, Gonzalez-Alujas, M T, Oristrell, G, Rodriguez-Palomares, J, Tornos, P, Aguade-Bruix, S, Smettei, O, Abazid, R, Ahmed, W M K, Samy, W, Behairy, N, Tayeh, O, Hassan, A, Berezin, A, Kremzer, A, Samura, T, Berezina, T, Scrima, G, Bertuccio, G, Canseco Nadia, Ncl, Cruz Raul, C R, Gonzalez Cristian, G C, Hernandez Salvador, S H, Alexanderson Erick, Ear, Zerahn, B, Shugushev, Z, Maximkin, D, Chepurnoy, A, Volkova, O, Tsedenova, A, Faibushevich, A, Baranovich, V, Yoshida, H, Mizukami, A, Matsumura, A, Keller, M, Silber, S, Falcao, A, Imada, R, Azouri, L O, Giorgi, McP, Santos, R D, Mello, S L, Kalil Filho, R, Meneghetti, J C, Chalela, W A, Kanni, L, Ohrman, T, Nygren, A T, Irabi, R D, Parisotto, T, Soares, J, Burrell, S, Lo, C, Zavadovskyi, K, Gulya, M, Lishmanov, Y U, Amin, A, Kandeel, Ahmed, Shaban, Mahmud, Nawito, Zeinab, Caobelli, F, Soffientini, A, Thackeray, J T, Bengel, F M, Pizzocaro, C, Guerra, U P, Hellberg, S E, Silvola, Jmu, Kiugel, M, Liljenback, H, Savisto, N, Thiele, A, Laine, Vjo, Knuuti, J, Roivainen, A, Saraste, A, Ismail, B, Hadizad, T, Dekemp, Rob, Beanlands, Rob, Dasilva, J N, Hyafil, F, Sorbets, E, Duchatelle, V, Rouzet, F, Le Guludec, D, Feldman, L, Martire, V D, De Pierris, C, Martire, M V, Pis Diez, E R, Ramaiah, V, Lebasnier, A, Legallois, D, Peyronnet, D, Desmonts, C, Zalcman, G, Bienvenu, B, Agostini, D, Manrique, A, Solomyanyy, V, Mintale, I, Zabunova, M, Narbute, I, Ratniece, M, Jakobsons, E, Kaire, K, Kamzola, G, Briede, I, Jegere, S, Erglis, A, Mostafa, S, Abdelkader, M, Abdelkader, H, Abdelkhlek, S, Khairy, E, Huidu, S, Popescu, A, Lacau, S, Huidu, A, Dimulescu, D, Sayed, S, Al Harby, F, Habeeb, A, Saqqah, H, Merganiab, S, Selvanayagam, J, Harms, H J, Tolbod, L P, Hansson, N H, Kero, T, Orndahl, L H, Kim, W Y, Bouchelouche, K, Wiggers, H, Frokiaer, J, Sorensen, J, Tolbod, L, Hansen, E, Zaremba, T, Kero, Tanja, and Sörensen, Jens

Published
2015
Full Text
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26. Diagnostic accuracy of markers for prodromal Alzheimer's disease in independent clinical series

Author

Prestia, Annapaola, Caroli, Anna, Herholz, Karl, Reiman, Eric, Chen, Kewei, Jagust, William J., Frisoni, Giovanni B, Amicucci, G., Archetti, S., Benussi, L., Binetti, G., Bocchio Chiavetto, L., Bonetti, M., Canu, E., Caobelli, F., Cavedo, E., Chittò, E., Costardi, D., Cotelli, M., Galluzzi, S., Gennarelli, Massimo, Geroldi, C., Ghidoni, R., Giubbini, Raffaele, Guerra, U. P., Kuffenschin, G., Lussignoli, G., Moretti, D., Orlandini, A., Paghera, B., Parapini, M., Paternicò, D., Porteri, C., Romano, M., Rosini, S., Scarpazza, C., Villa, I., Zanardini, Roberta, and Zanetti, O.

Subjects
Oncology, Male, Pathology, Time Factors, Databases, Factual, Epidemiology, Diagnostic accuracy, Disease, Hippocampal formation, Alzheimer's disease, Diagnostic test assessment, MCI, MRI, PET, Aged, Aged, 80 and over, Alzheimer Disease, Amyloid beta-Peptides, Biomarkers, Cognition Disorders, Disease Progression, Female, Fluorodeoxyglucose F18, Hippocampus, Humans, Magnetic Resonance Imaging, Middle Aged, Peptide Fragments, Positron-Emission Tomography, Sensitivity and Specificity, Statistics, Nonparametric, Cerebrospinal fluid, 80 and over, Health Policy, Medicine (all), Statistics, Psychiatry and Mental Health, Cohort, Biomarker (medicine), Psychology, medicine.medical_specialty, Article, Neurology (clinical), Developmental Neuroscience, Cellular and Molecular Neuroscience, Geriatrics and Gerontology, Databases, Neuroimaging, Internal medicine, medicine, Nonparametric, Factual, Memory clinic
Abstract

Objective To capitalize on data from different clinical series to compare sensitivity and specificity of individual biomarkers for predicting mild cognitive impairment (MCI) progression to Alzheimer's disease (AD). Methods Medial temporal atrophy, cortical hypometabolism, and cerebrospinal fluid biomarkers were assessed in 18 patients with mild cognitive impairment (MCI) with prodromal AD (pAD; conversion time, 26 ± 12 months) and 18 stable MCI (sMCI) patients from the Translational Outpatient Memory Clinic cohort, as well as in 24 pAD patients (conversion time, 36 ± 12 months) and 33 sMCI patients from the Alzheimer's Disease Neuroimaging Initiative cohort. Medial temporal atrophy was measured by manual, semi-automated, and automated hippocampal volumetry; cortical hypometabolism was measured using several indices of AD-related hypometabolism pattern; and cerebrospinal fluid markers were amyloid β (Aβ)42 and total tau protein concentrations. For each biomarker, sensitivity for pAD, specificity for sMCI, and diagnostic accuracy were computed. Results Sensitivity to predict MCI conversion to AD in the Alzheimer's Disease Neuroimaging Initiative and Translational Outpatient Memory Clinic cohorts was 79% and 94% based on Aβ42, 46% and 28% based on hippocampal volumes, 33% to 66% and 56% to 78% based on different hypometabolism indices, and 46% and 61% based on total tau levels, respectively. Specificity to exclude sMCI was 27% and 50% based on Aβ42, 76% and 94% based on hippocampal volumes, 58% to 67% and 55% to 83% based on different hypometabolism indices, and 61% and 83% based on total tau levels, respectively. Conclusions Current findings suggest that Aβ42 concentrations and hippocampal volumes may be used in combination to best identify pAD.

Published
2013

27. The relationship between cerebral vascular disease and parkinsonism: The VADO study

Author

Antonini, A., Vitale, C., Barone, P., Cilia, R., Righini, A., Bonuccelli, U., Abbruzzese, G., Ramat, S., Petrone, A., Quatrale, R., Marconi, R., Ceravolo, R., Stefani, A., Lopiano, L., Zappia, M., Capus, L., Morgante, L., Tamma, F., Tinazzi, M., Colosimo, C., Guerra, U. P., Valzania, F., Fagioli, G., Distefano, A., Bagnato, A., Feggi, L., Anna, S., Maria Teresa Rosaria De Cristofaro, Nobili, F., Mazzuca, N., Baldari, S., Eleopra, R., Bestetti, A., Benti, R., Varrone, A., Volterrani, D., Massa, R., Stocchi, F., Schillaci, O., Dore, F., Zibetti, M., Castellano, G., Battista, S. G., and Giorgetti, G.

Subjects
Male, Pathology, Parkinson's disease, Parkinson’s disease, Vascular parkinsonism, Dopamine transporter SPECT imaging, Gastroenterology, Severity of Illness Index, Antiparkinson Agents, Cohort Studies, Levodopa, Basal ganglia, 80 and over, Medicine, Tomography, Aged, 80 and over, Parkinsonism, Parkinson Disease, Magnetic Resonance Imaging, Tomography, Emission-Computed, Single-Photon, Humans, Corpus Striatum, Aged, Cerebrovascular Disorders, Cross-Sectional Studies, Dopamine Plasma Membrane Transport Proteins, Middle Aged, Parkinsonian Disorders, Female, MR Imaging, Neurology, Frontal lobe, Settore MED/26 - Neurologia, medicine.symptom, medicine.drug, MR imaging, medicine.medical_specialty, Internal medicine, Severity of illness, business.industry, Vascular disease, medicine.disease, Dyskinesia, nervous system, Neurology (clinical), Emission-Computed, Geriatrics and Gerontology, business, Single-Photon
Abstract

Background The observation of gait abnormalities, parkinsonism and vascular lesions in elderly patients is often reported as vascular parkinsonism (VP). However the status of striatal dopamine transporter (DAT) and the effects of brain vascular lesions on motor features and levodopa responsiveness are poorly defined. Methods We recorded clinical features, chronic response to levodopa and vascular risk factors in a cross-sectional cohort of consecutive elderly patients with possible Parkinson's disease (PD) or VP recruited in 20 centers in Italy. Results We included a total of 158 patients. Onset of motor symptoms was asymmetric in 93 (59%) and symmetric in 65 patients (41%). Symmetric motor onset was associated with greater disease severity. Chronic levodopa response was positive in 75 (47.8%) and negative in 82 patients (52.2%). A negative response to levodopa was associated with greater frequency of symmetric onset of motor symptoms, worst disease severity, absence of dyskinesia and greater number of vascular risk factors. Frontal lobe showed largest vascular load. Striatal DAT was normal in 48 (30.4%) and abnormal in 110 (69.6%) patients. Patients with normal DAT binding showed higher vascular load at MRI. Significant predictive factors of worst disease severity and negative response to levodopa were hypertension, vascular lesions in basal ganglia/periventricular regions, and normal DAT uptake. Conclusions Multiple cerebral vascular lesions modify clinical presentation and severity in patients with parkinsonism and this is underlined by specific risk factors primarily hypertension. Striatal DAT assessment is helpful in identifying patients where therapy benefit is less likely.

Published
2012

28. [Development of a distance education program in the public health system in Chile, 2004-2009]

Author

Jorge, Carabantes C, Manuel, Guerra U, and Michèle, Guillou

Subjects
Education, Distance, National Health Programs, Health Occupations, Health Personnel, Humans, Public Health, Chile
Abstract

This paper reports the gradual development and results achieved in the distance education program set up in the Public Health System in Chile in 2004. Up to date, more than 22,000 students from 29 different health divisions have been trained. This strategy was designed to provide more flexibility and diversity to the training programs of the Health System within the framework of a deep and complex organizational change promoted by Health Reform. The main results show that the integration of organizational, teaching, logistic and budgetary aspects has turned out to be a key element in its success, validating the relevance of the provided solutions. The access to training by means of e-learning or blended learning (electronic education that includes traditional and distance learning activities) allowed employees to choose more independently what, where and when to study. This fact accounts for the high demand for this program. Through this initiative, the National Health System, introduced a wider scope of responses to training needs, which will mean a better adaptation to the challenges associated to health care.

Published
2011

29. Desarrollo de un sistema de educación a distancia en el sector público de salud: 2004-2009

Author

CARABANTES C, JORGE, GUERRA U, MANUEL, and GUILLOU, MICHÈLE

Subjects
Health care reform, Allied health personnel, Computer-assisted instruction
Abstract

This paper reports the gradual development and results achieved in the distance education program set up in the Public Health System in Chile in 2004. Up to date, more than 22,000 students from 29 different health divisions have been trained. This strategy was designed to provide more flexibility and diversity to the training programs of the Health System within the framework of a deep and complex organizational change promoted by Health Reform. The main results show that the integration of organizational, teaching, logistic and budgetary aspects has turned out to be a key element in its success, validating the relevance of the provided solutions. The access to training by means of e-learning or blended learning (electronic education that includes traditional and distance learning activities) allowed employees to choose more independently what, where and when to study. This fact accounts for the high demand for this program. Through this initiative, the National Health System, introduced a wider scope of responses to training needs, which will mean a better adaptation to the challenges associated to health care.

Published
2010

30. Desarrollo de un sistema de educación a distancia en el sector público de salud: 2004-2009

Author

Jorge Carabantes C, Manuel Guerra U, and Michèle Guillou

Subjects
medicine.medical_specialty, Scope (project management), business.industry, Health care reform, Public health, Distance education, Flexibility (personality), General Medicine, Public relations, Computer-assisted instruction, Blended learning, Health care, medicine, Allied health personnel, business, Adaptation (computer science), Diversity (business)
Abstract

This paper reports the gradual development and results achieved in the distance education program set up in the Public Health System in Chile in 2004. Up to date, more than 22,000 students from 29 different health divisions have been trained. This strategy was designed to provide more flexibility and diversity to the training programs of the Health System within the framework of a deep and complex organizational change promoted by Health Reform. The main results show that the integration of organizational, teaching, logistic and budgetary aspects has turned out to be a key element in its success, validating the relevance of the provided solutions. The access to training by means of e-learning or blended learning (electronic education that includes traditional and distance learning activities) allowed employees to choose more independently what, where and when to study. This fact accounts for the high demand for this program. Through this initiative, the National Health System, introduced a wider scope of responses to training needs, which will mean a better adaptation to the challenges associated to health care.

Published
2010

31. Poster Session 3: Tuesday 5 May 2015, 08:30-12:30 * Room: Poster Area

Author

Ferreira, M., primary, Robalo, M., additional, Saraiva, T., additional, Cunha, M., additional, Goncalves, L., additional, Albuquerque, A., additional, Ramos, D., additional, Costa, G., additional, Lima, J., additional, Pego, M., additional, Peovska, I., additional, Davceva Pavlovska, J., additional, Pop Gorceva, D., additional, Zdravkovska, M., additional, Vavlukis, M., additional, Kostova, N., additional, Bulugahapitiya, D. S., additional, Feben, A., additional, Avison, M., additional, Foley, J., additional, Martin, J., additional, De Graaf, M. A., additional, Van Den Hoogen, I., additional, Leen, A., additional, Kharagjitsingh, A., additional, Kroft, L., additional, Jukema, J., additional, Bax, J., additional, Scholte, A., additional, Patel, K., additional, Mahan, M., additional, Ananthasubramaniam, K., additional, Durmus Altun, G., additional, Alpay, M., additional, Altun, A., additional, Andreini, D., additional, Pontone, G., additional, Mushtaq, S., additional, Bertella, E., additional, Conte, E., additional, Segurini, C., additional, Volpato, V., additional, Petulla, M., additional, Baggiano, A., additional, Pepi, M., additional, Van Dijk, J., additional, Huizing, E., additional, Jager, P., additional, Slump, C., additional, Ottervanger, J., additional, Van Dalen, J., additional, Yambao, E., additional, Calleja, H., additional, Sibulo, A., additional, Ramirez Moreno, A., additional, Siles Rubio, J., additional, Noureddine, M., additional, Munoz-Bellido, J., additional, Bravo, R., additional, Martinez, F., additional, Valle, A., additional, Milan, A., additional, Inigo-Garcia, L., additional, Velasco, T., additional, Ramaiah, V. L., additional, Devanbu, J. S., additional, Taywade, S. K., additional, Hejjaji, V. S., additional, Zafrir, N., additional, Bental, T., additional, Gutstein, A., additional, Solodky, A., additional, Mats, I., additional, Kornowski, R., additional, Lagan, J., additional, Hasleton, J., additional, Meah, M., additional, Mcshane, J., additional, Trent, R., additional, Massalha, S., additional, Israel, O., additional, Koskosi, A., additional, Kopelovich, M., additional, Marai, I., additional, Venuraju, S., additional, Jeevarethinam, A., additional, Dumo, A., additional, Ruano, S., additional, Darko, D., additional, Cohen, M., additional, Nair, D., additional, Rosenthal, M., additional, Rakhit, R., additional, Lahiri, A., additional, Pizzi, M. N., additional, Roque, A., additional, Fernandez-Hidalgo, N., additional, Cuellar-Calabria, H., additional, Gonzalez-Alujas, M., additional, Oristrell, G., additional, Rodriguez-Palomares, J., additional, Tornos, P., additional, Aguade-Bruix, S., additional, Smettei, O., additional, Abazid, R., additional, Ahmed, W. M. K., additional, Samy, W., additional, Behairy, N., additional, Tayeh, O., additional, Hassan, A., additional, Berezin, A., additional, Kremzer, A., additional, Samura, T., additional, Berezina, T., additional, Scrima, G., additional, Bertuccio, G., additional, Canseco Nadia, N., additional, Cruz Raul, C., additional, Gonzalez Cristian, G., additional, Hernandez Salvador, S., additional, Alexanderson Erick, E., additional, Zerahn, B., additional, Shugushev, Z., additional, Maximkin, D., additional, Chepurnoy, A., additional, Volkova, O., additional, Tsedenova, A., additional, Faibushevich, A., additional, Baranovich, V., additional, Yoshida, H., additional, Mizukami, A., additional, Matsumura, A., additional, Keller, M., additional, Silber, S., additional, Falcao, A., additional, Imada, R., additional, Azouri, L., additional, Giorgi, M., additional, Santos, R., additional, Mello, S., additional, Kalil Filho, R., additional, Meneghetti, J., additional, Chalela, W., additional, Kanni, L., additional, Ohrman, T., additional, Nygren, A. 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N., additional, Hyafil, F., additional, Sorbets, E., additional, Duchatelle, V., additional, Rouzet, F., additional, Le Guludec, D., additional, Feldman, L., additional, Martire, V., additional, De Pierris, C., additional, Martire, M., additional, Pis Diez, E., additional, Ramaiah, V., additional, Lebasnier, A., additional, Legallois, D., additional, Peyronnet, D., additional, Desmonts, C., additional, Zalcman, G., additional, Bienvenu, B., additional, Agostini, D., additional, Manrique, A., additional, Solomyanyy, V., additional, Mintale, I., additional, Zabunova, M., additional, Narbute, I., additional, Ratniece, M., additional, Jakobsons, E., additional, Kaire, K., additional, Kamzola, G., additional, Briede, I., additional, Jegere, S., additional, Erglis, A., additional, Mostafa, S., additional, Abdelkader, M., additional, Abdelkader, H., additional, Abdelkhlek, S., additional, Khairy, E., additional, Huidu, S., additional, Popescu, A., additional, Lacau, S., additional, Huidu, A., additional, Dimulescu, D., additional, Sayed, S., additional, Al Harby, F., additional, Habeeb, A., additional, Saqqah, H., additional, Merganiab, S., additional, Selvanayagam, J., additional, Harms, H., additional, Tolbod, L., additional, Hansson, N., additional, Kero, T., additional, Orndahl, L., additional, Kim, W., additional, Bouchelouche, K., additional, Wiggers, H., additional, Frokiaer, J., additional, Sorensen, J., additional, Hansen, E., additional, and Zaremba, T., additional

Published
2015
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40. Computed tomography, magnetic resonance and gallium 67 scintigraphy for the imaging of residual lymphoma

Author

Francesco Zaja, Russo, D., Silvestri, F., Fanin, R., Infanti, L., Bendini, M., Zuiani, C., Englaro, E., Cattaruzzi, E., Guerra, U. P., Zaja, F, Russo, D, Silvestri, F, Fanin, R, Infanti, L, Bendini, M, Zuiani, C, Englaro, E, Cattaruzzi, E, Guerra, Up., Zaja, Francesco, Fanin, Renato, Zuiani, Chiara, and Guerra, Up

Subjects
Adult, Male, Tomography, Emission-Computed, Single-Photon, Adolescent, Humans, Female, Gallium Radioisotopes, Tomography, X-Ray Computed, Hodgkin Disease, Magnetic Resonance Imaging
Abstract

The introduction of computed tomography (CT) has greatly improved lymphoma staging procedures and is presently the most common and most important radiologic technique employed for this purpose and for evaluating the response to treatment. However, since CT only gives an anatomic measure of the tumor, in some cases (particularly those with bulky mediastinal involvement), it is not useful in distinguishing between non-tumor images like fibrotic scars and residual neoplastic tissue following treatment. In such cases it may be difficult to reach a conclusion about the state of remission and to make an appropriate decision regarding subsequent treatment. Magnetic resonance (MR), with T1 and T2 sequences, and gallium 67 (67 Ga) scintigraphy (planar and SPECT) may help to elaborate a functional image that permits more careful appreciation of the nature of post therapeutic residual tissue.1-5 Furthermore, 67 Ga planar total body scintigraphy can detect lymphomatous involvement in sites that usually cannot be explored by thoracic and abdominal CT, which is currently used for staging purposes. We report here the images from two patients affected by Hodgkin’s disease (HD), obtained by CT, MR and 67 Ga planar and SPECT scintigraphy.

Published
1995

43. Applications of the HICAM gamma camera

Author

Busca, P, primary, Peloso, R, additional, Fiorini, C, additional, Gola, A, additional, Abba, A, additional, Erlandsson, K, additional, Hutton, B F, additional, Bianchi, C, additional, Poli, G L, additional, Guerra, U, additional, Virotta, G, additional, Ottobrini, L, additional, Martelli, C, additional, Lucignani, G, additional, Pedretti, A, additional, Van Mullekom, P, additional, Incorvaia, S, additional, and Perotti, F, additional

Published
2010
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45. Clinical and histopathological risk factors to predict sentinel lymph node positivity, disease-free and overall survival in clinical stages I–II AJCC skin melanoma: Outcome analysis from a single-institution prospectively collected database

Author

Mandalà, M., primary, Imberti, G.L., additional, Piazzalunga, D., additional, Belfiglio, M., additional, Labianca, R., additional, Barberis, M., additional, Marchesi, L., additional, Poletti, P., additional, Bonomi, L., additional, Novellino, L., additional, Di Biagio, K., additional, Milesi, A., additional, Guerra, U., additional, and Tondini, C., additional

Published
2009
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